"Afobazole": side effects. "Afobazol": instructions for use. Afobazol: instructions for use, analogues and reviews, prices in Russian pharmacies Afobazol 10 mg instructions for use

Tranquilizers of different groups.

Composition Afobazol

The active substance is morphodihydrochloride.

Manufacturers

Valenta Pharmaceuticals (Russia), Pharmstandard-Leksredstva OJSC (Russia), Shchelkovo Vitamin Plant (Russia)

pharmachologic effect

Afobazole is a selective non-benzodiazepine anxiolytic.

Acting on sigma-1 receptors in nerve cells of the brain, Afobazole stabilizes GABA/benzodiazepine receptors and restores their sensitivity to endogenous inhibitory mediators.

It also increases the bioenergetic potential of nerve cells and protects them from damage (has a neuroprotective effect).

The effect of the drug is realized primarily as a combination of anxiolytic (anti-anxiety) and mild stimulating (activating) effects.

Afobazole reduces or eliminates feelings of anxiety (preoccupation, apprehension, apprehension, irritability), tension (fearfulness, tearfulness, restlessness, inability to relax, insomnia, fear), somatic manifestations of anxiety (muscular, sensory, cardiovascular, respiratory, gastrointestinal) intestinal symptoms), autonomic disorders (dry mouth, sweating, dizziness), cognitive disorders (difficulty concentrating, impaired memory).

The use of the drug is especially indicated in persons with predominantly asthenic personality traits in the form of anxious suspiciousness, uncertainty, increased vulnerability and emotional lability, and a tendency to emotional stress reactions.

The effect of the drug develops on days 5-7 of treatment.

The maximum effect is achieved by the end of 4 weeks of treatment and persists after the end of treatment for an average of 1-2 weeks.

Afobazole does not cause muscle weakness, drowsiness and does not have a negative effect on concentration and memory.

When using it, drug dependence does not form and “withdrawal” syndrome does not develop.

After oral administration, it is well and quickly absorbed from the gastrointestinal tract.

The maximum concentration of the drug in plasma is 0.130+0.073 mcg/ml; time to reach maximum concentration – 0.85+0.13 hours.

Metabolism:

• Afobazole undergoes a “first pass effect” through the liver,
• The main directions of metabolism are hydroxylation at the aromatic ring of the benzimidazole ring and oxidation at the morpholine fragment.

Afobazole is intensively distributed throughout well-vascularized organs; it is characterized by rapid transfer from the central pool (blood plasma) to the peripheral (highly vascularized organs and tissues).

The half-life of Afobazole when taken orally is 0.82+0.54 hours.

The short half-life is due to intensive biotransformation of the drug and rapid distribution from blood plasma to organs and tissues.

The drug is excreted primarily in the form of metabolites and partially unchanged in urine and feces.

Side effects Afobazole

Allergic reactions are possible.

Rarely - headache, which usually goes away on its own and does not require discontinuation of the drug.

Indications for use

Used in adults for anxiety conditions:

• generalized anxiety disorders,
• neurasthenia,
• adaptation disorders,
• in patients with various somatic diseases (bronchial asthma,
• irritable bowel syndrome,
• systemic lupus erythematosus,
• coronary heart disease,
• hypertension,
• arrhythmias,
• dermatologically,
• oncological and other diseases.

In the treatment of sleep disorders associated with anxiety, neurocirculatory dystonia, premenstrual syndrome, alcohol withdrawal syndrome, to alleviate the “withdrawal” syndrome when quitting smoking.

Contraindications Afobazole

Individual intolerance to the drug.

Galactose intolerance, lactase deficiency or glucose-galactose malabsorption.

Pregnancy, lactation period.

Children under 18 years of age.

Directions for use and dosage

Used internally after meals.

Optimal single doses - 10 mg; daily - 30 mg, divided into 3 doses during the day.

The duration of the course of use of the drug is 2-4 weeks.

Overdose

With significant overdose and intoxication, the development of sedation and increased drowsiness without manifestations of muscle relaxation is possible.

As an emergency solution, caffeine 20% solution in 1.0 ml ampoules is used 2-3 times a day subcutaneously.

Interaction

The drug does not interact with ethanol and does not affect the hypnotic effect of thiopental.

Enhances the anticonvulsant effect of carbamazepine.

Causes an increase in the anxiolytic effect of diazepam.

special instructions

The drug does not have a negative effect on driving vehicles and performing potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Storage conditions

In a dry place, protected from light, out of the reach of children, at a temperature not exceeding 25 C.

Reading time: 9 min

Before buying the tranquilizer Afobazol, we recommend that you carefully study the proposed instructions, which describe the dosage, methods of use, and concomitant effects of this medicine on the human body. It must be taken into account that only a doctor can professionally correlate the patient’s problem and the restriction to taking Afobazole, so you should not self-medicate.

The “Psychology and Psychiatry” website offers all the important information on the following issues: indications and instructions for use of Afobazole, recommended dosage, contraindications, popular analogues, reviews from patients and doctors.

Afobazole is a drug from the group of anxiolytics (tranquilizers) of a non-bezodiazepine structure, which has a moderate activating effect in combination with the relief of anxiety. Afobazole has a very mild effect compared to benzodiazepines, does not cause the development of drug dependence and does not provoke withdrawal syndrome after stopping use. The drug is used to treat anxiety in adults caused by various factors (for example, upcoming surgery, stress, etc.) or mental disorders (for example, generalized, adaptation disorder, etc.).

Afobazol - composition, release form, packaging

fabomotizole (in the form of dihydrochloride) 5 mg

Excipients: potato starch - 48 mg, microcrystalline cellulose - 40 mg, lactose monohydrate - 48.5 mg, medium molecular weight povidone (medium molecular weight polyvinylpyrrolidone, Kollidon 25) - 7 mg, magnesium stearate - 1.5 mg.

Tablets are white or white with a creamy tint, flat-cylindrical, with a bevel.

fabomotizole (in the form of dihydrochloride) 10 mg

Excipients: potato starch - 48 mg, microcrystalline cellulose - 35 mg, lactose monohydrate - 48.5 mg, medium molecular weight povidone (medium molecular weight polyvinylpyrrolidone, Kollidon 25) - 7 mg, magnesium stearate - 1.5 mg.

Afobazole - pharmacological action

The pharmacological effect of the drug is anxiolytic.

Pharmacodynamics

Afobazole is a selective non-benzodiazepine anxiolytic. Acting on σ1 receptors in nerve cells of the brain, Afobazol stabilizes GABA/benzodiazepine receptors and restores their sensitivity to endogenous inhibitory mediators. Afobazole also increases the bioenergetic potential of neurons and has a neuroprotective effect: it restores and protects nerve cells.

The effect of the drug is realized primarily as a combination of anxiolytic (anti-anxiety) and mild stimulating (activating) effects. Afobazole reduces or eliminates feelings of anxiety (concern, bad feelings, fears), irritability, tension (fearfulness, tearfulness, anxiety, inability to relax), depressive mood, somatic manifestations of anxiety (muscular, sensory, cardiovascular, respiratory, gastrointestinal) intestinal symptoms), autonomic disorders (dry mouth, sweating, dizziness), cognitive disorders (difficulty concentrating, impaired memory), including those arising from stress disorders (disorders). The use of the drug is especially indicated in persons with predominantly asthenic personality traits in the form of anxious suspiciousness, uncertainty, increased vulnerability and emotional lability, and a tendency to emotional stress reactions.

The effect of the drug develops on the 5th–7th day of treatment. The maximum effect is achieved by the end of the 4th week of treatment and persists after the end of treatment for an average of 1–2 weeks.

Afobazole does not cause muscle weakness, drowsiness and does not have a negative effect on concentration and attention. When using it, addiction does not form, drug dependence does not develop, and “withdrawal” syndrome does not develop.

Pharmacokinetics

Suction

After oral administration, Afobazole is well and quickly absorbed from the gastrointestinal tract. Cmax in plasma - (0.13±0.073) μg/ml; Tmax - (0.85±0.13) h.

Distribution

Afobazole is intensively distributed throughout well-vascularized organs; it is characterized by rapid transfer from the central pool (blood plasma) to the peripheral (highly vascularized organs and tissues).

Metabolism

Afobazole undergoes a first-pass effect through the liver; the main directions of metabolism are hydroxylation at the aromatic ring of the benzimidazole ring and oxidation at the morpholine fragment.

Removal

T1/2 of the drug Afobazole when taken orally is (0.82±0.54) hours. The short T1/2 is due to the intensive biotransformation of the drug and rapid distribution from blood plasma to organs and tissues. The drug is excreted primarily in the form of metabolites and partially unchanged in urine and feces.

Afobazol - indications for use

Afobazole is used in adults for anxiety conditions, namely:

Generalized anxiety disorders;

Neurasthenia;

Adaptation disorders.

In patients with various somatic diseases, namely:

Bronchial asthma;

Irritable bowel syndrome;

Systemic lupus erythematosus;

Hypertonic disease;

Arrhythmias;

Dermatological, oncological and other diseases.

During treatment:

Sleep disorders associated with anxiety;

Neurocircular dystonia;

Premenstrual syndrome;

To relieve withdrawal symptoms when quitting smoking.

Afobazole is most effective in eliminating anxiety in cardiovascular diseases, premenstrual syndrome and neurocirculatory dystonia. According to scientific research, this particular drug is the optimal remedy for relieving depression, tearfulness and depression inherent in people suffering from heart disease.

Afobazole - dosage

Afobazole tablets can be taken immediately in full dosage, rather than increasing it gradually, since they have a mild effect, as a result of which the body does not need time to “get used” to the drug.

You can also abruptly, immediately stop taking Afobazole, like, for example, regular tablets for coughs, headaches, etc. There is no need to gradually reduce the dosage of Afobazole with the aim of subsequently discontinuing the drug. The ability to immediately stop taking the drug at any time is due to the fact that it does not cause drug dependence in humans, and, consequently, withdrawal syndrome, which is very difficult to tolerate and is a real “scourge” of benzodiazepine tranquilizers.

This ability to start taking the drug immediately in the required full dosage and, if necessary, stop taking it at once, makes Afobazol very simple and accessible to use. There is no need to initially increase the dosage of the drug to the required level over 2–3 weeks, and then slowly reduce it after completing the course of therapy with the goal of subsequent complete withdrawal.

In addition, the ease of use of Afobazole allows you to take it in a trial mode - that is, take the tablets for 4 - 5 weeks, wait for the full therapeutic effect to develop and evaluate whether this particular drug is right for you. If it fits, then you can simply continue taking it, and if not, then stop taking it on the same day and switch to other medications.

When switching from Afobazole to other anti-anxiety drugs, you should remember that its effects last for 1 to 2 weeks. Therefore, in order to avoid unwanted reactions, it is recommended to start taking another drug 2 weeks after stopping Afobazole.

After completing therapy with other tranquilizers, Afobazole can be started after 7 to 10 days.

Afobazole - how to take it correctly

The tablets should be taken after meals, swallowed whole, without chewing, biting or crushing in any other way. The tablet should be taken with a small amount of clean still water.

It is optimal to take Afobazole 10 mg (1 tablet of 10 mg or 2 tablets of 5 mg) 3 times a day, keeping approximately equal intervals between doses. With this regimen, the single dosage is 10 mg, and the daily dosage is 30 mg.

The duration of standard therapy is usually from two to four weeks, after which it is necessary to interrupt the drug. After 4 weeks it will be possible to undergo treatment with Afobazole again.

If necessary, and only under the supervision of a physician, the dosage of Afobazole can be increased to 20 mg three times a day, and the duration of continuous therapy – up to three months. However, any increase in dosage above 10 mg and duration of drug use beyond 4 weeks should be done only after consultation with a doctor.

It should be remembered that Afobazole can be used in repeated courses, keeping an interval of at least 4 weeks between them.

Afobazol - contraindications and side effects

Contraindications to taking the drug are as follows:

Individual intolerance to the drug;

Galactose intolerance, lactase deficiency or glucose-galactose malabsorption;

Pregnancy, lactation period;

Children under 18 years of age;

The use of Afobazole is contraindicated during pregnancy.

If it is necessary to use the drug during lactation, breastfeeding should be discontinued.

As side effects, Afobazole can provoke various allergic reactions and headaches, which, as a rule, go away on their own, without requiring special treatment or discontinuation of the drug. Some people note the appearance of pronounced intimate desire a few days after starting to take Afobazole. Doctors and scientists do not classify this effect as a side effect, but associate the appearance of libido with the relief of tension and anxiety.

What is better than Afobazole - Persen or Novopassit?

Persen and Novopassit are natural herbal sedatives with an almost identical spectrum of therapeutic effect, designed to relieve anxiety, anxiety and other exclusively psychological unpleasant symptoms and manifestations associated with increased anxiety.

Afobazole is a drug intended to relieve severe anxiety, as well as associated not only unpleasant psychological symptoms, but also somatic manifestations, such as pressure surges, extrasystole, palpitations, etc. That is, Persen and Novopassit relieve exclusively psychological discomfort, and Afobazol additionally eliminates somatic manifestations of increased anxiety. In addition, Afobazole moderately activates the central nervous system, improving memory and attention, and practically without causing drowsiness. Therefore, Persen and Novopassit can be recommended for use solely for the purpose of calming down, when a person is tormented by fears, anxiety, tension and other psychological symptoms of nervousness that are not associated with somatic manifestations.

Afobazole is recommended for use in the presence of not only psychological symptoms of increased anxiety, but also somatic manifestations of this condition (sweating, palpitations, extrasystole, pressure surges, etc.). In addition, Afobazole does not cause drowsiness and moderately activates the central nervous system, so the drug can be taken by people who want to lead an active lifestyle, drive a car, negotiate constructively and solve complex problems, and not “explode” and get irritated for various reasons. Persen and Novopassit are not suitable for solving such a problem, since they only calm down, without inducing them to solve any problems at all, but introducing a person into a state of conditional “not giving a fuck.”

In medicine, there are no concepts of “best” or “worst” drugs, so doctors prefer to use the term “optimal”. The fact is that for each specific person in a certain situation, any one, maximum two, drugs are best suited. It is these drugs, which are the most effective in a particular situation, that are considered optimal. It is necessary to understand that the optimal drugs for each individual person will be different. Moreover, even for the same person, different drugs may be optimal in different situations. Thus, it is simply impossible to calculate 1 – 2 “best” drugs that would be universally suitable for all people with all forms and variants of anxiety. Therefore, for some Afobazol will be the best drug, while another person will need a different drug that will be “best” for him.

Afobazole is a moderate anxiolytic that works well for many people to relieve anxiety. However, some note that for them its effect is insufficient, since anxiety is not relieved and the condition does not approach the desired one. This category of people prefers to use anxiolytics with a stronger anti-anxiety effect, which include the following drugs: Phenibut; Phenazepam (one of the most powerful anxiolytics); Diazepam; Lorazepam; Alprazolam.

The above tranquilizers are benzodiazepines and have a pronounced anti-anxiety effect, which, however, is combined with drowsiness, lethargy and depression, which are absent in Afobazole. It is these powerful tranquilizers that people usually say that they put you into a “vegetable” state, when, along with anxiety, any desire to do anything disappears.

The following drugs occupy an intermediate position between powerful benzodiazepines and Afobazole in terms of the severity of the anti-anxiety effect: Chlordiazepoxide; Bromazepam; Gidazepam; Clobazam; Oxazepam. Among the listed drugs, Gidazepam is most often used to relieve anxiety, which many people consider better than Afobazole. In addition to those mentioned, there are quite a large number of drugs that have an anti-anxiety effect, but it is necessary to find the “best” one among them individually.

Afobazole - analogues

There are no drugs that are absolutely identical to Afobazole in terms of action and composition; there are some products that have similar properties. However, all these medications have some differences. Before you start taking them, you should definitely consult your doctor.

The most commonly used Afobazole analogues are as follows:

Adaptol - this drug belongs to the group of anxiolytic-type drugs. This drug has a tranquilizing effect. When taken, it quickly relieves feelings of fear, tension, fatigue, and stress.

Divaza is a drug that belongs to the group of tranquilizers. When taken, the active component normalizes blood circulation in the brain, relieves tension and fatigue. It is taken during autonomic disorders, for disorders of brain activity that are caused by injuries, ischemic diseases, neurodegenerative diseases and others. And also for increased anxiety, insomnia, headaches, and neuroinfections.

Tenoten is a drug belonging to the group of tranquilizers. Quickly relieves anxiety, stress, emotional tension, helps relieve headaches and eliminates sleep problems.

Persen. This remedy has an antispasmodic and calming effect. It contains herbal ingredients that help relieve tension, anxiety and irritation. It can be taken during insomnia, because the drug facilitates the process of falling asleep and does not cause drowsiness.

Phenazepam is a highly active tranquilizer. The drug has anxiolytic, anticonvulsant, hypnotic and central muscle relaxant effects on the body. It is used during sleep disorders, neurotic and psychopathic conditions.

Novopassit is a sedative-type sedative that consists of herbal components. The medicine has an effect on the nervous system, relieves nervous tension, fatigue, and stress. Also helps with headaches and sleep disorders.

Grandaxin is a tranquilizer that belongs to the group of benzodiazepines. Quickly relieves tension, fatigue, excitability, helps with headaches and insomnia. It is also taken for premenstrual syndrome, for myopathy, myasthenia gravis, neuroses, for alcohol withdrawal syndrome, and so on.

Phenibut is a nootropic drug that is classified as a tranquilizer. Improves brain activity, increases blood circulation. When taken, the body's performance and mental activity increase, memory improves, stress, neuroses, and tensions disappear.

Mebicar is a drug that is classified as a tranquilizer for daytime use. This drug reduces anxiety, tension, fatigue, and also has a mild sedative effect.

Phenzitate is a tranquilizer that belongs to the group of benzodiazepine derivatives. It is used for neuroses, severe fatigue, emotional stress, autonomic disorders, and sleep disorders.

Cheap analogues of Afabozole include the following drugs: Phenazepam, its cost is about 120-140 rubles; Persen, the price is 280-300 rubles; Novopassit, cost ranges from 150 to 180 rubles; Mebikar, the price per package is about 280-300 rubles; Phensitate, the cost of packaging is 140-180 rubles.

The following analogues of Afabozole are available without a prescription: Persen; Novopassit; Phenibut; Tenoten; Fenzitate.

Analogs of Afobazole produced in Russia: Divaza; Tenoten; Phenazepam; Mebicar; Fenzitate.

Reviews from doctors about Afobazole

Smirnova E.A., pharmacist, pharmacy

Afobazole is a tranquilizer (anxiolytic). Its action is aimed at relieving anxiety, neurasthenia and adaptation disorders. The drug perfectly combines both anti-anxiety and activating effects. Its advantages also include the absence of negative effects on memory and attention; it does not cause addiction in the patient. Afobazole is not a muscle relaxant. The drug helps well in the fight against irritability, tearfulness, inability to relax, feelings of fear and insomnia. In a word, Afobazol helps to cope with the consequences of stressful situations that we often have to face in everyday life. It is important for women to know that this drug should not be taken during pregnancy or while breastfeeding. The drug is also contraindicated for persons under 18 years of age. The drug is available in tablets, which is a certain convenience for patients; it should be taken after meals. The drug is non-toxic. Afobazole is most optimal for people prone to emotional stress reactions and people with increased vulnerability and uncertainty.

Kiseleva V.E., pharmacist, pharmacy

Afobazole tablets are used for increased nervous excitability, anxiety, and for the treatment of various types of phobias (fears). The drug does not have a hypnotic effect, so it can be used by drivers behind the wheel. Afobazole is for the treatment of adults only.

Uchelkina L.A.pharmacist

Afobazole belongs to the pharmacotherapeutic group - tranquilizers, does not cause addiction, drowsiness, or muscle weakness.

Ionova O. pharmacist

Afobazole reduces feelings of anxiety (concern, bad feelings, fears, irritability), tension (fearfulness, tearfulness, anxiety, fear). Improvement in condition is observed on days 5–7 of treatment. The maximum effect is achieved by the end of 4 weeks of treatment. The drug does not have muscle relaxant properties or a negative effect on memory and attention. With its use, drug dependence does not form and withdrawal syndrome does not develop, which means it can be prescribed to those people who are involved in driving. The maximum daily dose is 3 tablets.

Platonov D. G. Psychotherapist, Candidate of Sciences

It was not possible to identify any anti-anxiety effect for patients with any neurotic level of anxiety. I’m silent about normal research. All positive patient reviews of the drug are undoubtedly explained by the placebo effect. Well, like any placebo, it has no side effects. The drug could make sense if it at least claimed to act quickly (like, for example, Adaptol), since possible use is limited to situational anxiety manifestations: for example, it could be used for fears of public speaking.

Pashyan D. A. Dentist

This drug has a certain anti-anxiety effect. It is possible that the effect of this drug is not an effect at all, but a “placebo” effect. As in any other case, it is better to consult with your doctor before taking medication; you may need a much more effective (prescription) drug.

Komissarov V. B. Chiropractor

"Afobazol" is an inexpensive and effective drug. The price is affordable, available without a prescription. Very effectively relieves feelings of danger, nervousness, anxiety, and insomnia. Well normalizes sleep. I recommend taking it periodically to patients, especially with a combination of anxiety and insomnia. The drug is well tolerated and side effects are rare.

Patient reviews about Afobazole

Kate

It really helped me not to go crazy while on maternity leave. After all, I’m a mother of twins, and this, I’ll tell you, is worse than a hurricane or a tsunami. And if you consider that the husband spends most of his time at work, and there is no one from his relatives to help, then he has to carry everything on himself. Both the household and the children. Eventually, there comes a time when you just want to lie down in silence, close your eyes and never wake up again. Now I remember these thoughts and am horrified how I could even seriously think about this. 3 months of taking afobazole returned me to a human state, refreshed my brain and patched up my nerves. So now, with renewed vigor, we go into battle, as they say. The only warning: these tablets are contraindicated for GW.

Svetlana Vasilievna

Today “Afobazol” is my favorite drug, I take it in connection with menopause: it relieves arrhythmias, tension, improves sleep, a neurologist recommended it to me. I have the main disease DEP (dyscirculatory encephalopathy), this drug suited me. I advise women to take it during their transition period.

Elena B.

And I had a severe allergic reaction from Afobazole, even to the point of angioedema. The first time I drank it, I didn’t understand what it was from it, but when I drank it a week later, everything happened again, only Suprastin didn’t help, I had to dig it out. It’s good that I was at work, our doctors helped me, if it had happened on the road, I don’t know how it would have turned out. I don’t know, they say I’m the first to have such a reaction to Afobazole.

Victoria D.

I moved with my husband to another city (he was sent there for work). Of course, the city is foreign, there are no acquaintances, friends and family, and no work. And we have been living there for about 5 years. Because of all this, I closed myself off, became very irritable, and was constantly haunted by incomprehensible fears (that I would never be able to settle down here, find a job, that my husband would leave me, that something would happen to my parents without me, because I was not there). nearby and the like). I had to somehow cope with all this, I didn’t want to go to psychologists, and I don’t know how to choose them - I run into charlatans. I decided to start with sedatives; the pharmacy recommended Afobazol, which they say is a good anti-anxiety medication. I won’t say that the effect of it came on the same day of administration. I had to wait, after about a week I felt the effect. I drank for 2 months. Fears and obsessive thoughts went away and never returned (pah-pah), some kind of confidence appeared, I almost stopped being nervous, I pulled myself together, found a job and was even able to make friends. I definitely believe that the drug helped.

Nina G.

I needed sedatives, but for a long time I couldn’t decide which one to choose. I took the risk of trying Afobazol on the advice of friends. Since I often drive, it was important for me that the tablets did not cause drowsiness and did not slow down my reaction. I got it right with the drug. Another big plus was that the effect of the tablets persisted for quite a long time after discontinuation of the drug.

Marika H.

I took Afobazol with my husband as a couple. Since we had been together for a long time, life was busy and there was constant stress at work, we often quarreled over trifles, always dissatisfied with each other. After 1.5 months of being together, our family is idyllic again. I'm glad that I finally found a drug that suited me perfectly. It does not have any side effects. And since I drive all the time, this is simply a salvation for me.

Stanislav L.

“Afobazol” is a fairly effective remedy; I took it along with “Neurofulol” as prescribed by the doctor. I got my nerves in order and am now calm and happy. Although many places write that these two drugs are quite similar in action, there is no point in taking them at the same time. And, basically, experts make a choice more towards Neurofulol, as it is more effective. But my doctor, apparently, decided to play it safe.

Anna L.

I have been taking it for 3 years, always in courses - it really helps to cope with psychosis, both at work and in family life. I walk calmly, like three boa constrictors. "Novopassit" helps to calm down well, but all the positive effects are offset by the fact that it constantly makes you want to sleep. There is no such thing with Afobazol, she is always cheerful, and you can safely get behind the wheel. But at night I fall asleep like the dead.

Polina E.

I never recommend something that I haven’t tried myself. So, afobazole has been tested and verified by me personally, so I can recommend it to those who are experiencing stress or a similar nervous and emotional state. I always argue when they say that it doesn’t help instantly. This is even better, I am always suspicious of drugs that promise help the very next day. It doesn't happen that way. So it is in the case of afobazole: it is a comprehensive, serious approach that is good.

Alena M.

I have been taking the drug for several years; in my opinion, it is one of the best anti-anxiety drugs. Of course, it’s not even close to any valerian. It's strange to read such comparisons. Have you never taken difficult exams with valerian in your youth? I passed it and I don’t want to repeat this experience. It’s good that there are modern drugs that calm you down and don’t make you sleepy.

Marina M.

In a certain situation, “Afobazol” turned out to be exactly the drug that coped and helped me get through the difficulties. At that time I was taking it for the first time and didn’t know what to expect, I only knew that I had to take it in a course and wait for the effect not immediately, but in a couple of weeks. That's how it turned out. I managed to get my unpleasant emotions under control.

Daria R.

I work in the service industry, so I interact directly with clients. And there are a lot of dissatisfied people. At the same time, I need to keep my mark, always remain, let’s say, in emotional form. This is why sometimes you have to resort to the help of afobazole. I like it, its long-lasting effect - I’ll take a course, then I’ll be calm for several months.

Alina A.

The drug is completely ineffective. It contains very little active ingredient, so it does not have the desired effect. It is well suited for people who like to take pills, for suspicious people, because it does not cause adverse reactions, and is not even capable of causing poisoning in large doses. The placebo effect on the face. Well, for people who are under stress, it is also not effective, a waste of money and not a small one.

Alena A.

The first time I needed a sedative was when my mother became seriously ill. Anyone who has cared for a bedridden relative will understand me. On the advice of a doctor, I purchased Afobazol. For many, this drug does not help at all, but it worked very well and quickly for me. Maybe it’s because I’ve never taken sedatives before, or maybe I’m very thick-skinned myself, but the nervousness and irritability went away the very next day after I started taking it. I am very pleased that there is no drowsiness or lethargy, and there are completely no problems with drug withdrawal. Now Afobazole is my lifesaver in stressful situations.

Tatiana V.

To be honest, the drug was useless for me. I took it as prescribed by my family doctor for the complex treatment of erosive gastritis. The state at that time was irritated, anxious, and the doctor suggested that this could negatively affect the outcome of the treatment. I took it for about a month, they say it has a cumulative effect and you can increase the intake up to 3 months. After the first month, without seeing the effect, I stopped taking it, because I thought that if the drug was effective for me, I could observe certain changes after this period. Perhaps he was not right for me, since I heard good reviews about him.

Liana K.

The times are now such that I would recommend Afobazole to many people; it would obviously be a good idea for people to drink it on the subway and at work. Why do I accept them all calmly, because I accept him. Otherwise I would have lost it long ago. But with him, such a thought doesn’t even arise: why make a scandal when you can be calm and control your emotions.

Ekaterina K.

My friend has a special child, it’s very difficult, of course, with him. Although she loves him madly, I see how she suffers, cries, gets angry. You give him a spoonful of porridge, and he hits you over the head with it and laughs... So, according to her, Afobazole helps her not to become limp in this situation.

Andrey F.

I like that it is not addictive, you can jump off at any time if you feel that you have had enough. Before that, I took valerian tablets, I slept normally with it, but without it, insomnia immediately began.

Maria P.

Mom works as a teacher, and high school makes her feel terrible. He says that after two weeks of drinking afobazole, he doesn’t find it so painful and somehow manages to cope with them. It’s not great, of course, that you have to take sedatives for this. Well, what can you do, your age and specialty are not at all appropriate for changing jobs.

Sergey V.

"Afobazole" helped me get rid of sleep problems. In my life there was a period of shift work at night, and the regime went to hell. It turns out that this greatly affects one’s well-being and overall adequacy. After that, I couldn’t sleep half the night, and only after a week of taking Afobazole did my sleep return to normal.

Elena K.

I tried everything to get my husband to quit smoking, and finally, with Afobazol, the two of us managed to achieve results! Before this, my husband became so irritable that I myself could not stand it and bought him a new pack, but now the withdrawal went smoothly.

Larisa M.

I have to sit next to a terrible colleague, he annoys me every day, and while the project is in full swing, there is no way to change the situation. Afobazole helped me grow zen and treat his sexist antics with healthy indifference.

Anna P.

They suddenly started creeping up on me, suddenly a wild fear began from somewhere, most often this happened in a dream, I suddenly woke up in wild horror with cold sweat on my forehead and sweaty palms. I didn’t dare go to the doctor, I was scared that they might force me to register with a psychiatrist. At the nearest pharmacy, the pharmacist recommended these tablets to me. To be honest, the price is steep. But I bought it. I took it according to the inner leaflet (instructions) for two weeks. And they really had an effect on me. The nightmare that had plagued me for several months has gone away. There are quite a lot of tablets in the pack, 60 pieces. I only drank half of it and decided to stop my treatment for now. If suddenly the attacks resume again, I will continue the treatment and finish the course to the end.

I liked this drug, after taking it for a week my anxiety decreased, my mood improved significantly, it was as if I had climbed out of a hole. Even if it was a placebo effect, I am more than satisfied with it.

Ekaterina Sh.

To be honest, I don’t understand the general admiration for this drug. The therapist prescribed me "Afobazol" when a neurotic disorder was just beginning, as a remedy for panic attacks, anxiety, fear and growing pain. I remember that the price of this drug is not low, but I bought it in the hope that it would help. From personal experience, I can say that there was no particular effect. All the problems remained relevant, anxiety did not decrease, panic attacks did not go away, although the situation was not acute at that time. Maybe it should be taken over a longer course, I don’t know. Personally, Afobazol did not help me.

Yana V.

I took Afobazol for a month on the recommendation of my neurologist. In my situation, the drug worked perfectly. It was protracted against the backdrop of the death of a loved one. As far as I understand, the drug does not help with acute problems. Works well in cases where the person does not need strong drugs and only minor adjustments are required. There were no side effects at all and there was no addiction either.

Elena P.

Good afternoon After the birth of the child, problems with nerves arose. She became irritable, tearful, constantly lashed out at her husband, and even had hysterics. I tried many sedatives, but to no avail. The pharmacy advised me to buy Afobazol. Although the drug is not cheap, I decided to try it. Let me tell you right away, there will be no instant relief. I took 2 tablets a day. My mood became more positive after about 2 weeks of taking it, I became more tolerant and calmer. I liked the fact that there is no sleeping pill effect. In general, the drug suited me.

Alyonka S.

The doctor prescribed Afobazol to calm the nerves and lower the temperature. Regarding the first, there were no changes. I am quick-tempered and emotional. But Afobazl does not relieve these symptoms. I had neurocirculatory dystonia (who knows - the symptoms are terrible), which arose due to stress. Then cheap Alora tablets helped me. "Afobazol" costs more, but does not give the same result. Afobazol was prescribed to me when my temperature was 37.7 (lasted for more than a month). Then the psychotherapist suggested that this was a violation of the thermocenter. This is where Afobazol coped with the problem.

Julia N.

Before the flight, my mother was advised to drink Afobazol, as she is very afraid of flying, since she was in a situation where the plane made an emergency landing. She drank in the evening and we didn’t know what to do with her! She was imagining some creatures, her fears worsened, and instead of a sedative, we observed the absolutely opposite effect. They barely calmed her down before the plane and gave her sleeping pills. So in our case, this medicine played a cruel joke.

Katya M.

Honestly, not my medicine. Of course, there is a sedative effect, but my personal feeling is the same as regular valerian tablets. But the plus is that it is not as addictive as valerian, I took a course and don’t want it anymore. I didn’t find any side effects, although I have more than one chronic disease. Yes, it still doesn’t interfere with concentration, and I haven’t noticed any drowsiness either.

Milana S.

At the moment, this is one of the best drugs that can bring the human nervous system into a balanced state. My husband regularly takes afobazole due to constant stressful situations at work. The drug is absolutely harmless, and most importantly, does not cause drowsiness, which is very important when working as a driver. Even with long-term use, there is no addiction to the drug and there are no side effects.

Olga K.

Since my job is very stressful, I always had headaches and felt disgusting. She was nervous and squeezed like a lemon. After consulting with my doctor, they discovered that I had mental fatigue and prescribed me to take Afobazol. The medicine is really good. At least it helped me. And now, in extreme situations and to prevent mental disorder, I always take only Afobazole. The price is of course high, but the drug helps me, that’s why I buy it.

Inessa K.

For the first time, the desire to drink a sedative arose when, sitting at home all day with my child, I felt that I was going crazy, everything was heating me up (mothers will understand me, endless lack of sleep, monotony). But I was skeptical about such drugs. A good friend, a pharmacist, suggested trying Afobazol because he trusts it. I bought it... I took it only as indicated in the instructions, after a couple of weeks I realized (I took it for a month in total) that everything was fine, I stopped taking it out on my household, problems became trifles, because everything can be solved. And my mood improved!

Tatiana S.

The doctor prescribed Afobazole to me when I found myself in a difficult everyday situation and my nerves were on edge. I was a little afraid to take these pills for fear of addiction, but since my mental state left much to be desired, I was constantly crying, I had no other choice. What can I say? I liked the tablets. I drank them for 2 months, during this time I became calmer, I had the feeling that after using Afobazole I began to look at everything as if through a bus window, a little detached or something, but there was no drowsiness or addiction, I just stopped taking it as needed and that's it.

Helga B.

A good anti-anxiety drug, it relieves excess tension well and increases stress resistance in the rhythm of intense work activity. It does not cause drowsiness or impaired coordination of movements, which allows you to drive a car while taking it. I am very pleased that the drug is not addictive.

Storage conditions and shelf life

Store at a temperature not exceeding 25°C.

Keep out of the reach of children.

The shelf life of the drug Afobazol is 3 years.

Do not use after the expiration date stated on the package.

Conditions for dispensing from pharmacies: Without a prescription.

We would like to emphasize that the above description of the anti-anxiety drug Afobazol serves an informational function only! More precise guidance on the use of the proposed tranquilizer can be obtained by studying the instructions officially approved by the manufacturer. Remember - self-medication is irresponsible and unsafe for health! We strongly recommend that you consult a doctor before starting Afobazole therapy.

This drug falls into the group of tranquilizers, but at the same time has a very gentle effect on the human body. It does not cause addiction in the patient and does not provoke the development of withdrawal syndrome upon completion of therapy. In order to get only benefits from taking the drug, you must strictly follow the instructions for use of Afobazole.

Today, the only form of release of Afobazole is tablets. They are painted in a snow white/cream color. There are two dosage options for the main active ingredient in pills – 5 and 10 mg. Tablets are packaged in blisters or glass jars (from 10 to 100 pieces, depending on the packaging option).

The main active component of the product is fabomotizol. The product also includes auxiliary ingredients: starch (potato), lactose monohydrate and some others. The composition turned out to be the same for both dosage options.

Pharmacological properties and indications for use

The main active component of the drug reduces a person’s feelings of anxiety, calms them down, eliminates irritability and even has a beneficial effect on mood. At the same time, unlike most analogues, the drug does not cause memory loss, does not reduce brain activity and concentration, and does not lead to the development of drowsiness and other similar effects. In addition, it does not create drug dependence.

In addition to eliminating anxiety, the drug has the following effects on the patient’s body:

• struggles with bad premonitions, feelings of concern, fear, etc.;
• improves night sleep (without morning and daytime sleepiness);
• relieves psycho-emotional stress;
• helps relax.

The medicine leads to a decrease in spasm of the muscles of the genital organs, reduces sweating, relieves dizziness and dry mouth.

It is especially important to use this remedy for anxious, suspicious people with increased emotionality.

Soon after taking the drug, the main active substance is completely absorbed into the blood and quickly spreads throughout the body. Excreted by the kidneys.

Experts prescribe tablets for the following problems:

• sleep disturbance caused by anxiety;
• human social adaptation disorder;
• severe premenstrual syndrome;
• “withdrawal” in the fight against alcoholism and smoking;
• cardiopsychoneurosis.

The drug under discussion is often used as part of complex therapy for various serious diseases. For example, with asthma (bronchial), some problems with the heart and blood vessels (when oxygen and nutrients enter the heart muscle in quantities that are insufficient for its normal functioning), high blood pressure and some others. The medicine helps to cope with tearfulness, moodiness, depression, which are typical for patients suffering from various heart diseases.

Pills are also prescribed for ailments that cause a person to feel inferior and doubt the ability to be in society.

Instructions for use of "Afobazol"

It is very important to know exactly how to take Afobazol according to a regimen that is safe for the patient’s body. Such tablets, unlike other tranquilizers, can be taken in full portions immediately, rather than increasing the dosage slowly and gradually. This is due to the mild effect of the drug. It doesn't take time to get used to it. It is also possible to use the drug once, because it does not cause dependence in patients.

It must be remembered that after finishing taking the drug, its effect will persist for another 10 to 15 days. During this period, you should avoid other drugs with similar effects.

The drug is suitable only for adult patients. You should take the tablet soon after eating. It is consumed whole (without chewing or other damage). Take the medicine with water without sugar or gas. A small amount of liquid is enough.

• If this is the 10 mg option, then take 1 pill three times a day.
• If 5 mg, then 2 tablets in the same number of doses.

It is advisable to maintain approximately equal intervals between pills.

The standard course of therapy with this drug is 14–28 days. After the maximum period has passed, you should definitely stop taking it for a while. You can repeat the course no earlier than another month.

Increasing the duration of treatment and dosage is allowed only under the strict supervision of an experienced specialist.

Can I take it during pregnancy and lactation?

The medicine under discussion is a tranquilizer. It is strictly forbidden to take it during pregnancy, regardless of its duration. It is better for a woman to cope with feelings of anxiety during pregnancy with the help of folk remedies and special herbal remedies.

The drug is also prohibited during lactation. If a young mother decides to start taking the drug, she will have to transfer the baby to artificial feeding.

Compatibility of Afobazole and alcohol

The main active component of the drug under discussion does not react with ethyl alcohol. But this does not mean at all that Afobazole and alcohol can be safely drunk together.

Such information from the instructions for the product only suggests that the drug can be taken, for example, for a hangover. It helps to cope with the unpleasant symptoms accompanying this condition.

“Afobazole” stimulates the functioning of the nervous system, slows down the process of absorption of alcohol that has already entered the stomach, and accelerates the process of elimination from the body of substances formed during the breakdown of alcohol. At the same time, the drug is not suitable for the treatment of alcohol dependence at any stage. It can only relieve the main symptoms of a hangover and improve the general condition of the patient. For this purpose, it is taken no more than 2 times a day, 10–20 mg.

It must be remembered that alcohol neutralizes the healing effects of the medicine on many systems and organs. For example, if the product is used by women to improve their condition during menopause.

Just one serving of alcoholic drink will significantly reduce the effectiveness of Afobazole and cause all the unpleasant symptoms of the problem to return.

It is especially dangerous to combine the drug and alcohol for problems with the heart and blood vessels, lungs, and bronchi. Such “neighborhood” can also intensify the patient’s neurotic states.

Drug interactions with other drugs

As noted above, the components of the drug do not interact with ethyl alcohol. Therefore, it can be combined with some alcohol-based medications.

When using the product in parallel with Diazepam and Carbamazepine, you need to remember that it enhances their effect.

Contraindications, side effects and overdose

The drug under discussion also has a whole list of contraindications. It must be carefully studied before you start taking it.

The medicine is strictly prohibited if the patient has the following characteristics:

• hypersensitivity, intolerance to individual components of the product or allergic reactions to them;
• lactase deficiency;
• childhood.

If the patient is taking any medications (including to relieve the symptoms of chronic illnesses), he should be sure to inform the doctor who recommends taking Afobazole. This may cause changes in the regimen of taking new pills or even a delay in starting therapy.

Cases of drug overdose are rare, since the correct treatment regimen with such tablets is simple and clear. Usually the problem appears when the pills are taken in large quantities at once by mistake. If, over a long period of time, the patient slightly overestimates the dosage of the drug, then an overdose will not develop, because its components do not accumulate in the tissues of the body.

When a problem occurs, a person will experience the following symptoms:

• drowsiness without muscle weakness (it can appear even immediately after getting out of bed in the morning);
• excessive calmness and even “lethargy.”

A solution of sodium benzoate caffeine (20 percent) will help cope with an overdose. The drug is administered by injection 2-3 times per day, and always subcutaneously.

Patients treated with Afobazole may, in rare cases, experience side effects of the drug. First of all, among them it is necessary to highlight migraines and all kinds of allergic reactions (most often manifested in the form of skin rashes). Such manifestations do not require special treatment. There is no need to discontinue the drug.

It happens that patients notice an increase in sexual desire soon after starting therapy with the pills in question. This is not a side effect of the drug, but a consequence of relieving anxiety and nervous tension.

Analogues

Modern pharmacies offer a large number of Afobazole analogues. Among the cheapest is the Belarusian Phenibut. It is also prohibited for pregnant women.

Other analogues of Afobazole: Mebikar (produced in Russia), Anvifen, Atarax, Tenoten, Persen. Novo-Passit is also particularly popular among buyers.

Year-round vacation and relaxation... Perhaps this is the dream of a person of any age. Especially a working person who literally lives from vacation to vacation. What can we say about students whose eyes begin to twitch when they hear the word “session”.

Fortunately, medicine does not stand still, and for more than 50 years drugs have been developed that can relieve excessive anxiety and nervous breakdowns. They are called tranquilizers (another name is anxiolytics). Their effect on the nervous system is contained in the name itself - “dissolving anxiety”. Afobazole is a bright representative of this group of drugs, moreover, of the latest generation. Afobazol tablets are used to support and restore the nervous system when it cannot cope with excessive load and stress, which is manifested by excessive anxiety, irritability, restlessness and tension.

Composition of Afobazol tablets

The active ingredient of Afobazole is fabomotizole. Its difference from anxiolytics of previous generations is its non-standard mechanism of action. The fact is that it acts not on those receptors that are on the surface of the neuron (nerve cell), but on those located inside it. Due to this, it is possible to avoid the side effects characteristic of most anxiolytics, but more on that later.

Excipients are standard - starch, lactose and others. They make up the bulk of the tablet and help preserve the properties of the drug throughout the shelf life.

Afobazol tablets - indications for use

Afobazole tablets are used for a wide range of nervous system disorders caused by both stress factors and somatic diseases.

Generalized anxiety disorders, adaptation disorders, neurasthenia - these conditions are indications for the use of Afobazole. Problems at work, at home, hassle in traffic jams, natural emotionality and sentimentality can trigger the occurrence of such conditions. What can we say about premenstrual syndrome, “withdrawal” syndrome when quitting smoking and alcohol withdrawal syndrome! These conditions sometimes frighten not only their owners, but also those around them, especially loved ones. Afobazole will help you get through difficult periods of quitting a bad habit.

Somatic diseases - diseases of internal organs, such as bronchial asthma, coronary heart disease, arrhythmias, arterial hypertension, irritable bowel syndrome - cause a similar unpleasant condition. The inconvenience and unpleasant, painful sensations that accompany such diseases, the need to regularly visit a doctor, constantly take medications obsessively distract from pressing matters... This cannot but cause tension. At the same time, increased anxiety and tension often provoke a worsening of the course of somatic diseases.

Other types of diseases - for example, skin diseases - in addition to consultation with specialists and therapy, sometimes require psychological support. Afobazole will ease the patient's morale, reducing anxiety about the disease and possible external defects.

It is known that nervous tension is often followed by insomnia. Lack of sleep in the morning makes it even worse... Often, taking sleeping pills means getting enough sleep, but being sluggish throughout the next day. Afobazole will help normalize sleep disturbed by anxiety and tension, make it easier to fall asleep, but will not make you nod off during the day.

Afobazole: shelf life, storage conditions, sales conditions

The storage temperature of Afobazole should not exceed 25o C, shelf life - 3 years. Its advantage is its over-the-counter distribution - you can purchase it yourself in pharmacies.

Afobazole instructions

Especially if you purchase Afobazol tablets yourself, the instructions for use are required to be studied! Tablets are standardly produced at 10 mg, 60 pieces per package. Afobazole must be taken in a course. The usual dosage is 1 tablet 3 times a day for 2-4 weeks. If necessary, the doctor may prescribe an increase in dose to 20 mg (two tablets) at a time.

Contraindications

There are no special contraindications to the use of Afobazole tablets. The drug should not be taken if you are hypersensitive to any of the components, incl. galactose, with lactase deficiency or glucose-galactose malabsorption. Also, the drug should not be used during pregnancy, lactation and children under 18 years of age. These are special groups of patients, so specialized studies are necessary.

Overdose

In case of an overdose, the maximum that awaits is increased drowsiness.

Side effects

Anxiolytics are divided into two groups: benzodiazepines and non-benzodiazepines. Their name is taken from the name of the benzodiazepine receptors, which are located on the surface of the neuron. Drugs that act on these receptors cause inhibition of the neuron, which leads to not only anxiolytic, but also sedative effects, which often causes daytime sleepiness, muscle weakness, impaired concentration of memory and attention.

But they found a solution to this problem - Afobazole does not act on surface receptors. It affects sigma receptors located inside the neuron. These receptors are responsible for restoring the structures and functions of nerve cells in various disorders. Under the influence of Afobazole, their activation occurs, which leads to the restoration of the sensitivity of neuron membrane receptors to their own inhibitory mediators. In this way, the natural (physiological) processes of inhibition in the central nervous system are restored. Therefore, Afobazole eliminates anxiety and tension without having a sedative effect, without causing daytime sleepiness, impaired attention and memory, or muscle weakness. In the morning, a person can calmly get behind the wheel or take on other physical or mental work that requires concentration. This is an undeniable advantage.

Drug interactions

Afobazole can be taken with alcohol - they do not interact. However, it should be remembered that excessive amounts of alcohol can negatively affect the functioning of the nervous system. Caution is required when taken concomitantly with carbamazepine or diazepam. In the first case, the anticonvulsant effect is enhanced, in the latter - the anxiolytic effect. It is better to consult a doctor so that the overall effect is not excessive.

Afobazol tablets - analogues

Along with Afobazole, the anxiolytics Grandaxin and Phenibut are well known to many. They are also anti-anxiety drugs, but with different active ingredients. Extreme caution should be exercised when using them, due to a wide range of side effects, contraindications and the risk of drug interactions with other drugs. These drugs are available only with a doctor's prescription.

Prohibited during pregnancy

Prohibited during breastfeeding

Prohibited for children

Has restrictions for older people

Has limitations for liver problems

Has limitations for kidney problems

Constant stressful situations, anxiety states, chronic neuroses can lead to severe disorders not only of the nervous system, but also to dysfunction of the entire body. To combat stress, depression and neuroses, the use of benzodiazepine tranquilizers or antidepressants is justified.

The undoubted advantages of these funds include the speed of action. Despite their effectiveness, the use of such medications can be addictive. Doctors recommend resorting to such therapy only in emergency cases. Afobazole differs from other drugs in this group in that, according to the instructions for use, it is not addictive, and in that it can be used for long-term treatment.

Afobazole is an optimal replacement for antidepressants and tranquilizers. The absence of side effects when used, addiction effects and withdrawal symptoms are the distinctive features of the drug.

Significant advantages of Afobazole are its low level of toxicity to the body and the possibility of use in complex therapy.

Also, long-term use of Afobazole is not accompanied by drowsiness, irritability, lethargy and deterioration in a person’s standard of living. The medicine is widely used among doctors and patients, and can be purchased at a pharmacy without a prescription.

Drug group, INN, scope of application

Afobazole refers to selective non-benzodiazepine drugs with anxiolytic properties, derivatives of 2-mercaptobenzimidazole (does not apply to benzodiazepine receptor agonists). The INN of the drug is Afobazol.

The drug is widely used in psychiatry and neurology, in general somatic practice for symptoms of depression, psychopathological disorders and in cases of pathological anxiety, which can occur in the form of attacks or be constantly present.

In cases of anxiety attacks, the patient complains of panic attacks, autonomic dysfunction of the body, and the development of social phobia. In the chronic form, persistent depressive and stressful conditions, as well as adaptation disorders, are most often observed. To treat these cases, if long-term drug treatment is required, doctors use Afobazole.

Release forms and prices for the drug, average in Russia

The medicine can be purchased in the form of beige or white round flat tablets. They are produced in quantities of 10, 20, 25 pieces in plates and 30, 50, 60, 100 pieces in plastic jars. Most often sold in quantities of 60 pieces per jar. The country of origin of the drug is Russia. Average prices for Afobazole are presented in the table.

Composition and pharmacological properties

One tablet contains 5 mg or 10 mg of fabomotizole dihydrochloride. Additional substances included include:

• potato starch – 48 mg;
• lactose monohydrate – 48.5 mg;
• medical medium molecular weight polyvinylpyrrolidone – 7 mg;
• Magnesium stearate – 1.5 mg.

Before starting therapy, it is important to understand how Afobazole works. The action of the drug is aimed at sigma-1 receptors of nerve cells in the brain, due to which GABA receptors are stabilized.

The medicine restores the structure of the GABA-benzodiazepine receptor complex thanks to sigma-1 receptors, which leads to the normal process of binding GABA to the receptors. It also restores the high sensitivity of these receptors to inhibitory mediators. The medicine has a protective and restorative effect on nerve cells, and also preserves their bioenergy reserve.

The action of Afobazole is represented by a combination of anxiolytic and weak stimulating effects. The anxiolytic effect is responsible for eliminating anxiety. Thanks to these effects, the medicine can significantly reduce the feeling of anxiety and the preceding feelings of concern and apprehension, irritability, and tension.

Patients feel relief from tearfulness, fear, insomnia, unreasonable fears, depressive mood and constant feelings of stress, dysfunction of the digestive, cardiovascular, respiratory and musculoskeletal systems, sweating, and malaise.

After taking the drug, people note a restoration of concentration and memory, a complete absence of suspiciousness and the emergence of anxious thoughts, uncertainty and apathy. Patients' tendency to have strong emotional reactions to minor events disappears.

The medicine is well and quickly absorbed in the digestive system. Substances are carried in the blood and quickly spread throughout the body. The drug is metabolized in the liver due to the processes of hydroxylation and oxidative reactions.

It is excreted from the body not only in the form of metabolites, but also in unchanged form with feces and urine. Excretion occurs quickly, which is associated with the breakdown into metabolic products in the liver immediately after entering the body. With long-term use, the substances do not accumulate in the body.

When does it start to work?

The effectiveness of the drug can be noticed after taking the medicine for a week. The maximum effect of treatment is observed a month after the start of use and persists for several more weeks after its completion. Taking Afobazole does not provoke the appearance of muscle weakness, drowsiness, decreased concentration and memory. At the end of treatment, the occurrence of dependence or drug withdrawal syndrome is not recorded.

Indications and contraindications

Afobazole is used as an anxiolytic agent in cases of anxiety. It is important to know exactly what the remedy helps with. These are, in particular, conditions that manifest themselves:

Indications for use also include:

• attacks of anxiety and neurasthenia;
• bronchial asthma;
• lupus;
• hypertension;
• arrhythmia;
• dermatological diseases;
• oncological diseases;
• acute premenstrual syndrome;
• panic attacks;
• long-term alcohol or smoking withdrawal syndrome;
• insomnia.

The medicine is contraindicated for people with hypersensitivity to the components, people with lactase and galactose intolerance (as they are present in the composition), for children under 18 years of age and during pregnancy, because it crosses the placenta and can adversely affect the development of the fetus.

During breastfeeding, it is also not recommended to take medicine, however, in cases where treatment is necessary, breastfeeding is stopped until the end of taking Afobazole (which is due to the possibility of substances passing into breast milk).

It is also prohibited to take the drug for people with:

• brain diseases or injuries;
• diseases and dysfunctions of the peripheral and central nervous system;
• inhibition of the functionality of the central nervous system.

The drug does not affect the ability to drive vehicles or perform work that requires increased concentration.

Instructions for use

According to the instructions for use, Afobazole is taken orally after meals with water. The dosage depends on the nature of the underlying pathology.

Dosage and course duration for adults?

For adults, the minimum single dose in tablets is 10 mg, and the daily dose is 30 mg. It is recommended to distribute the dose into 3 doses during the day. The effectiveness of taking the drug can be noticed after a few weeks, and the maximum effect appears after a month. In some cases, the doctor may increase the daily dose to 60 mg and extend treatment to several months.

In the case of taking Afobazole, it is important when it is taken - before or after meals, since the safety of therapy depends on this. The optimal option is to take it half an hour after a meal.

For VSD and panic attacks

For VSD and panic attacks, it is very important to follow the rules for taking the medication. It must be remembered that the use of Afobazole for one-time relief of an attack is not effective. In order to see the result and eliminate the appearance of attacks, you must take the drug regularly. For severe forms of panic, drink 6 tablets 3 times a day. In case of mild forms of disorders, doctors recommend taking 3 tablets 3 times a day.

Treatment for panic attacks can last from several weeks to several months, which completely depends on the severity of the attacks. The results from taking Afobazole last for several weeks after stopping the pills. If panic attacks return and VSD symptoms appear, the doctor may prescribe re-treatment. In some cases, 6 tablets of Afobazole can cause side effects, so the dose is individually adjusted by the doctor for each patient.

Afobazole does not treat the causes of attacks, but only eliminates the manifestation and consequences of attacks.

In order to completely get rid of attacks, it is necessary to undergo treatment with a psychotherapist, since such attacks are the result of mental trauma received in childhood, hidden fears, severe stress and emotional turmoil, depression or manifestations of VSD.

Particularly dangerous are cases when panic is caused by mitral valve prolapse, hypothyroidism, hypoglycemia or a central nervous system disorder, which only a doctor can diagnose. Therefore, treatment with this medicine is recommended under the supervision of a specialist.

During menopause

Afobazole is also popular in gynecology. This medicine is prescribed to patients with severe symptoms of menopause, namely:

• sudden fluctuations in body temperature;
• feeling of weakness and malaise, decreased performance;
• increased emotionality;
• sweating;
• problems sleeping, insomnia;
• lack of sexual desire.

In such cases, it is recommended to take the drug three times a day, 1 tablet. The duration of treatment is determined by the gynecologist himself. In cases where these symptoms are accompanied by prolonged depression and stress, doctors recommend Afobazole in combination with sedatives.

Possible side effects and overdose of Afobazol

The drug causes side effects extremely rarely. The most common include itching, rash, and redness of the skin, which is caused by increased sensitivity to the composition of the drug. Dyspeptic processes can also sometimes occur, which are manifested by nausea, vomiting, abdominal pain, constipation, diarrhea or diarrhea. These symptoms disappear immediately after stopping taking the pills.

An overdose of the drug occurs when taking a large number of tablets. This quantity is considered to be a one-time dose of more than 6 tablets.

A drug overdose can be detected due to the appearance of the following symptoms:

• the appearance of sharp headaches reminiscent of migraines;
• drowsiness, weakness, malaise;
• difficult, slurred speech;
• inhibited reaction;
• weakened or heavy breathing;
• a sharp increase in heartbeat and its sharp weakening;
• the appearance of seizures;
• apathy.

These symptoms are provoked by depression of the central nervous system under the influence of a large amount of the active substance. If at least a few symptoms of an overdose are detected, it is necessary to provide the victim with first aid.

First of all, it is necessary to give the person a large amount of water and press on the root of the tongue, causing a gag reflex. This will help remove substances from the body that have not yet been absorbed in the digestive system. After this, the person is given an adsorbent, such as activated carbon, in order to remove all toxins. In cases of overdose, doctors advise giving the victim strong coffee, since caffeine reduces the effect of Afobazole on the nervous system.

In the following hours, it is necessary to give the person plenty of water, which will help remove the remaining substances in the body. After the condition improves, it is necessary to take the victim to a doctor for examination. In cases of severe intoxication of the body due to an overdose, the victim is treated in a hospital under the supervision of doctors until the functions of the body are completely restored.

Compatibility of Afobazole with drugs and alcohol

Afobazole enhances the effect of, which eliminates seizures, and which helps cope with frequent anxiety. Does not affect the action.

With Glycine

Glycine is a food additive that is a non-essential amino acid. It has a positive effect on the central nervous system, improves concentration, especially in the educational process, and also improves the cognitive properties of the body. Has no harmful effect on the body. Glycine is used as a nootropic drug that has sedative and sedative properties. It can be used not only for treatment, but also for complex therapy and prevention.

It is recommended to drink not only for sick people, but also for healthy people for prevention purposes. Glycine is prescribed to improve the quality of sleep and the stability of a person’s emotional state. This is achieved due to the influence of Glycine on the launch of GABA, that is, the inhibitory neurotransmitter. The drug is also widely used to treat various forms of VSD, as it has antioxidant and alpha-adrenergic blocking properties.

Afobazole, in turn, is used for more serious manifestations of nervous disorders and VSD. These drugs can be used simultaneously, as they do not affect the effectiveness and actions of each other.

With alcoholic drinks

According to the manufacturer, alcohol does not affect the effect of the drug. Despite this, doctors do not recommend taking medicine and alcohol together. With a one-time parallel intake of the drug and alcohol, no significant negative effects will occur.

In such cases, the drug may simply not show its effect, which is due to the fact that alcohol has a sedative and relaxing effect due to inhibition of the central nervous system. Afobazole gradually stimulates the nervous system, thus helping the patient cope with stress or anxiety.

Undesirable and unpredictable side effects may occur with prolonged concomitant use. Also, the medicine may lose its effectiveness due to the negative effect of alcohol on metabolism. In such cases, a person may begin to take pills in large quantities, and a large amount of the active substance and alcohol intoxication can cause death.

Doctors categorically prohibit drug treatment in cases of alcohol intoxication. The optimal period that should elapse between drinking alcohol and starting treatment is several days.

This period is individual for each person and depends on the amount of alcohol consumed. It should be remembered that in the event of interaction between alcohol and the active substance, the patient’s condition may worsen significantly, and unexpected consequences may occur, primarily associated with an increase in the disease.

Taking the drug to relieve hangover symptoms is pointless, since by the time Afobazole begins to act, the body itself will have gotten rid of alcohol intoxication. It has a positive effect only in cases of treating the consequences of long-term alcohol intake.

Features of therapy for stress and anxiety disorders

Afobazole helps cope with symptoms of stress and anxiety. Despite this, it does not affect the causes of these conditions. When you stop taking the medication, attacks may occur again. To eliminate the causes of stress and anxiety, you need to contact specialists.

To determine the effectiveness of the drug, studies were conducted at the Moscow and St. Petersburg psychoneurological research institutes. It has been proven that Afobazol is similar in action to Diazepam. The medicine differs from Diazepam in its high tolerability, lack of muscle relaxant effect and inhibition of cognitive functions. This was the reason for further research.

Scientists considered the main goal to establish the effectiveness of the drug in cases of anxiety. To do this, a naturalistic study was conducted in which people from 18 to 65 years old with nervous disorders, depression and anxiety participated. Exceptions were cases of schizophrenia, epilepsy, frequent panic attacks, and somatic diseases in the acute stage.

The subjects took the drug three times a day, 15-20 mg, for a month and a half. To better determine effectiveness, different evaluation techniques have been used. Each patient had his own card with notes on his condition, which was checked every 7 days.

194 patients were studied, 45 men, 149 women. Since nervous system disorders are more common in women, most of them were present. The experiment involved people with disorders lasting from several months to several years. For treatment, patients had previously used antidepressants or tranquilizers.

In the first week of the study, patients' anxiety levels decreased by 22%. In week 3 the numbers rose to 50%. By week 6, the rate reached 73%. Analysis of the results showed the presence of a constant and harmonious decrease in the severity of anxiety. Starting from the first week, patients complained less about their health.

Earlier studies have shown that side effects occur to a greater extent in the first week.

These effects were represented by increased anxiety, drowsiness, and sleep disturbance. Their most acute manifestation was an exacerbation of somatic disease. In general, side effects were very rare. The results showed that the effect of Afobazole does not depend on age or gender. It has also been shown that the drug reaches its maximum effect in the 3rd week after the start of treatment. At the end, it was found that the stimulating effect prevailed over the sedative.

The main disadvantage of this study is its lack of objectivity. This is due to the fact that not all patients could soberly assess the results of the drug. And the positive effect could arise solely due to people’s self-hypnosis.

To avoid such situations, the double placebo method is used, where half of the patients are given a placebo pill and the other half are given the real drug. Patients do not know which pills they are being treated with and are unaware of important details of the study. It is this method that helps determine that the effect of the drug is based on its properties, and not on the patients’ self-hypnosis. No data on such research methods have been found for Afobazole.

Studies have confirmed the high effectiveness of the drug in the treatment of neurotic disorders. The drug is also well tolerated and easy to use.