Amosin - instructions for use, contraindications, composition, release form, dosage and price. Review: use of the antibiotic Amosin for the treatment of children Amosin course of treatment

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In this article you can read the instructions for use of the drug Amosin. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of the antibiotic Amosin in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Amosin in the presence of existing structural analogues. Use for the treatment of sore throat, pneumonia, sinusitis and other infectious diseases in adults, children, as well as during pregnancy and lactation. Composition and interaction of the drug with alcohol.

Amosin- a broad-spectrum antibiotic from the group of semisynthetic penicillins. Acts bactericidal. Inhibits transpeptidase, disrupts the synthesis of peptidoglycan (supporting polymer of the cell wall) during division and growth, and causes lysis of bacteria. Acid resistant.

Active against aerobic gram-positive bacteria: Staphylococcus spp. (staphylococcus) (except penicillinase-producing strains), Streptococcus spp. (streptococcus); aerobic gram-negative bacteria: Neisseria gonorrhoeae, Neisseria meningitidis, Bacillus anthracis, Listeria monocytogenes (Listeria), Helicobacter pylori (Helicobacter), Klebsiella spp. (klebsiella).

Microorganisms that produce penicillinase are resistant to amoxicillin.

The action develops 15-30 minutes after administration and lasts 8 hours.

Compound

Amoxicillin (in trihydrate form) + excipients.

Pharmacokinetics

After oral administration, Amosin is quickly and almost completely (93%) absorbed from the gastrointestinal tract. Eating does not affect the absorption of the drug and is not destroyed in the acidic environment of the stomach. Found in high concentrations in plasma, sputum, bronchial secretions (distribution in purulent bronchial secretions is poor), pleural and peritoneal fluid, urine, contents of skin blisters, lung tissue, intestinal mucosa, female genital organs, prostate gland, middle ear fluid, bone , adipose tissue, gall bladder (with normal liver function), fetal tissue. When the dose is doubled, the concentration also doubles. The concentration in bile exceeds the concentration in plasma by 2-4 times. In the amniotic fluid and umbilical cord vessels, the concentration of amoxicillin is 25-30% of the plasma level in a pregnant woman. It penetrates the blood-brain barrier (BBB) ​​poorly; in case of inflammation of the meninges (meningitis), the concentration in the cerebrospinal fluid is about 20%. Plasma protein binding - 17%. A small amount is excreted in breast milk. Amoxicillin is partially metabolized to form inactive metabolites. Amoxicillin is excreted 50-70% unchanged in the urine by tubular excretion (80%) and glomerular filtration (20%), with bile - 10-20%.

Indications

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

• respiratory infections (including bronchitis, pneumonia);
• infections of the ENT organs (including sinusitis, pharyngitis, tonsillitis, acute otitis media);
• infections of the genitourinary system (including pyelonephritis, pyelitis, cystitis, urethritis, gonorrhea);
• gynecological infections (including endometritis, cervicitis);
• infections of the gastrointestinal tract (including peritonitis, enterocolitis, typhoid fever, cholangitis, cholecystitis);
• infections of the skin and soft tissues (including erysipelas, impetigo, secondary infected dermatoses);
• leptospirosis;
• listeriosis;
• Lyme disease (borreliosis);
• dysentery;
• salmonellosis, salmonella carriage;
• meningitis;
• endocarditis (prevention);
• sepsis.

Release forms

Capsules 250 mg.

Tablets 250 mg and 500 mg.

Powder for the preparation of suspension for oral administration 125 mg, 250 mg and 500 mg.

Instructions for use and dosage

The drug is taken orally, before or after meals. The dosage regimen is set individually, taking into account the severity of the disease, the sensitivity of the pathogen to the drug, and the age of the patient.

Adults and children over 10 years of age (with a body weight of more than 40 kg) are prescribed 500 mg 3 times a day, for severe cases of the disease - 0.75-1 g 3 times a day.

Children aged 5 to 10 years are prescribed 250 mg 3 times a day, from 2 to 5 years old - 125 mg 3 times a day, for children under 2 years old - 20 mg/kg per day in 3 divided doses. The course of treatment is 5-12 days.

For children under 5 years of age, the drug is prescribed in the form of a suspension (the ideal pediatric form of the drug).

For the treatment of acute uncomplicated gonorrhea, the drug is prescribed in a dose of 3 g once; When treating women, repeated administration of the indicated dose is recommended.

For acute infectious diseases of the gastrointestinal tract (paratyphoid fever, typhoid fever) and biliary tract, for gynecological infectious diseases, adults are prescribed 1.5-2 g 3 times a day or 1-1.5 g 4 times a day.

For leptospirosis, adults are prescribed 500-750 mg 4 times a day for 6-12 days.

For salmonella-carrying adults - 1.5-2 g 3 times a day for 2-4 weeks.

To prevent endocarditis during minor surgical interventions, adults are prescribed a dose of 3-4 g 1 hour before the procedure. If necessary, a repeat dose is prescribed after 8-9 hours. In children, the dose is halved.

Rules for preparing a suspension from a single-dose package

Boiled and cooled water is poured into a clean glass in the amount indicated in the table, then the contents of one package are poured out and mixed until a homogeneous suspension is obtained.

• The dose in the package is 125 mg - the required amount of water is 2.5 ml;
• dose in a package 250 mg - required amount of water 5 ml;
• dose in a package 500 mg - required amount of water 10 ml.

After use, rinse the glass with water, dry and store in a dry, clean place.

Side effect

• hives;
• skin hyperemia;
• erythema;
• angioedema;
• rhinitis;
• conjunctivitis;
• fever;
• joint pain;
• eosinophilia;
• exfoliative dermatitis;
• exudative erythema multiforme;
• Stevens-Johnson syndrome;
• reactions similar to serum sickness;
• anaphylactic shock;
• dysbacteriosis;
• change in taste;
• vomiting, nausea;
• diarrhea;
• stomatitis;
• glossitis;
• pseudomembranous enterocolitis;
• excitation;
• anxiety;
• insomnia;
• confusion;
• behavior change;
• depression;
• peripheral neuropathy;
• headache;
• dizziness;
• convulsive reactions;
• interstitial nephritis;
• leukopenia, neutropenia, thrombocytopenic purpura, anemia;
• labored breathing;
• tachycardia;
• vaginal candidiasis;
• superinfection (especially in patients with chronic diseases or reduced body resistance).

Contraindications

• allergic diathesis;
• bronchial asthma, hay fever;
• Infectious mononucleosis;
• lymphocytic leukemia;
• liver failure;
• history of gastrointestinal diseases (especially colitis associated with the use of antibiotics);
• lactation period (breastfeeding);
• hypersensitivity to the components of the drug;
• hypersensitivity to other penicillins, cephalosporins, carbapenems;
• children under 3 years of age (for tablets and capsules).

Use during pregnancy and breastfeeding

Use in children

Contraindicated in children under 3 years of age (for tablets and capsules). For children under 5 years of age, the drug is prescribed in the form of a suspension.

special instructions

When carrying out a course of treatment with Amosin, it is necessary to monitor the state of the function of the hematopoietic organs, liver and kidneys.

Superinfection may develop due to the growth of microflora insensitive to amoxicillin, which requires a corresponding change in antibacterial therapy.

When treating patients with bacteremia, a bacteriolysis reaction (Jarisch-Herxheimer reaction) rarely develops.

In patients who are hypersensitive to penicillins, cross-allergic reactions with cephalosporin antibiotics are possible.

When treating mild diarrhea while using Amosin, you should avoid prescribing antidiarrheal drugs that reduce intestinal motility; You can use kaolin- or attapulgite-containing antidiarrheal agents. In case of severe diarrhea, it is necessary to carry out differential diagnosis and prescribe appropriate therapy.

Treatment should be continued for another 48-72 hours after the disappearance of clinical signs of the disease.

When using estrogen-containing oral contraceptives and amoxicillin simultaneously, additional methods of contraception should be used, if possible.

Drug interactions

Antacids, glucosamine, laxatives, food, antibiotics of the aminoglycoside group, when used simultaneously, slow down and reduce the absorption of Amosin; ascorbic acid - increases its absorption.

Bactericidal antibiotics (including aminoglycosides, cephalosporins, cycloserine, vancomycin, rifampicin) exhibit synergism with amoxicillin; bacteriostatic drugs (macrolides, chloramphenicol, lincosamines, tetracyclines, sulfonamides) - antagonism.

Amoxicillin, when used simultaneously, increases the effectiveness of indirect anticoagulants (by suppressing intestinal microflora, reducing the synthesis of vitamin K and the prothrombin index); reduces the effectiveness of estrogen-containing oral contraceptives, ethinyl estradiol (the risk of intermenstrual bleeding), as well as drugs, during the metabolism of which para-aminobenzoic acid is formed.

The combined use of Amosin with alcohol is prohibited (the hepatotoxic effect of ethanol is enhanced).

Diuretics, allopurinol, oxyphenbutazone, phenylbutazone, nonsteroidal anti-inflammatory drugs (NSAIDs) and drugs that block tubular secretion, when used simultaneously with Amosin, reduce tubular secretion and increase the concentration of amoxicillin.

When Amosin is used simultaneously with allopurinol, the risk of developing a skin rash increases.

Amoxicillin, when used simultaneously, reduces the clearance and increases the toxicity of methotrexate.

Amoxicillin, when used simultaneously, enhances the absorption of digoxin.

Analogues of the drug Amosin

Structural analogues of the active substance:

• Amoxisar;
• Amoxicillin;
• Amoxicillin trihydrate;
• Gonoform;
• Grunamox;
• Danemox;
• Ospamox;
• Flemoxin Solutab;
• Hiconcil;
• Ecobol.

If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps and look at the available analogues for the therapeutic effect.

Amosin is a semi-synthetic drug from the group of penicillins with broad-spectrum antibacterial action.

Its effect is manifested in inhibition of the transpeptidase enzyme, disruption of the stability of cell walls, inhibition of the development of pathogenic microorganisms and their division at the cellular level, which ultimately causes lysis of pathogenic microflora.

On this page you will find all the information about Amosin: complete instructions for use for this drug, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Amosin. Would you like to leave your opinion? Please write in the comments.

Clinical and pharmacological group

A broad-spectrum penicillin antibiotic that is destroyed by penicillinase.

Conditions for dispensing from pharmacies

Dispensed with a doctor's prescription.

Prices

How much does Amosin cost? The average price in pharmacies is 30 rubles.

Release form and composition

Amosin is available in several dosage forms.

Amosin gelatin capsules, white, size No. 0. The contents of the capsules are white granules. Packaged in contour cells of 10 pieces.

Amosin tablets are white or almost white, flat cylindrical in shape, with a separating line and a chamfer. Packaged in contour cells of 10 pieces.

Amosin powder for the preparation of a suspension for oral administration has a white color with a yellowish tint and a specific odor. The prepared suspension is white with a yellowish tint and has a specific odor. Packaged in single-dose packages of 1.5; 3 and 6 years

Pharmacological effect

The active component of the medicinal product actively affects gram-negative bacteria - Neisseria meningitidis and Listeria monocytogenes and Bacillus anthracis, Klebsiella spp., Neisseria gonorrhoeae and Helicobacter pylori; for gram-positive staphylococcal and streptococcal bacteria. Pathogenic microflora that produce penicillinase are immune to the effects of the active component Amosin.

The effect of taking the medicinal drug appears in 15-30 minutes and lasts for 8 hours. The medicine is easily and within a short time absorbed by the walls of the gastrointestinal tract, and the presence of food in it does not affect the rate of absorption. The maximum content of amoxicillin is achieved in the blood plasma in the first 1-2 hours. The blood flow carries the active component of the drug to the mucous membranes of organs, bone and connective tissue, intraocular sputum and fluid. The elimination time of the drug through the kidneys averages two to three hours and may increase in patients with impaired renal function.

Indications for use

The antibiotic Amosin is prescribed for bacterial infections:

• Urogenital infections (cystitis, pyelonephritis, urethritis, pyelitis, gonorrhea);
• Infectious diseases of the digestive tract (dysentery, abdominal type, salmonellosis, cholecystitis);
• Borreliosis;
• Meningitis;
• Acute infectious diseases of the upper respiratory tract;
• Acute infectious diseases of the lower respiratory tract (bronchitis, pneumonia);
• Infections of ENT organs (acute otitis media, sinusitis, tonsillitis);
• Sepsis;
• Diseases of the skin and soft tissues (secondarily infected dermatosis, impetigo, erysipelas);
• Prevention of endocarditis and surgical infection.

Contraindications

Contraindications to the use of Amosin are:

• Liver failure;
• Bronchial asthma and hay fever;
• Allergic diathesis;
• Lymphocytic leukemia;
• Infectious mononucleosis;
• Diseases of the gastrointestinal tract;
• Hypersensitivity to amoxicillin and other penicillins, as well as carbapenems and cephalosporins;
• Breastfeeding period;
• Children under 3 years of age (for the dosage form in the form of capsules and tablets).

Amosin is prescribed with caution to pregnant women and patients with renal failure and a history of bleeding.

Use during pregnancy and lactation

The use of the drug during pregnancy is possible only in cases where the expected benefit of therapy for the mother outweighs the potential risk to the fetus.

Use during lactation is contraindicated. If use is necessary during lactation, breastfeeding should be stopped.

Instructions for use Amosin

The instructions for use indicate that Amosin is taken orally, before or after meals. The dosage regimen is set individually, taking into account the severity of the disease, the sensitivity of the pathogen to the drug, and the age of the patient.

• Adults and children over 10 years of age (with body weight >40 kg) are prescribed 500 mg 3 times a day, for severe disease - 0.75-1 g 3 times a day.
• Children aged 5 to 10 years are prescribed 250 mg 3 times / day, from 2 to 5 years - 125 mg 3 times / day, for children under 2 years - 20 mg / kg / day in 3 doses. The course of treatment is 5-12 days.
• For children under 5 years of age, the drug is prescribed in the form of a suspension.

For treatment of acute uncomplicated gonorrhea the drug is prescribed in a dose of 3 g once; When treating women, repeated administration of the indicated dose is recommended.

At acute infectious diseases of the gastrointestinal tract (paratyphoid fever, typhoid fever) and biliary tract, for gynecological infectious diseases adults are prescribed 1.5-2 g 3 times a day or 1-1.5 g 4 times a day.

At leptospirosis adults are prescribed 500-750 mg 4 times a day for 6-12 days.

At salmonella carriage adults - 1.5-2 g 3 times a day for 2-4 weeks.

For prevention of endocarditis during minor surgical interventions adults are prescribed a dose of 3-4 g 1 hour before the procedure. If necessary, a repeat dose is prescribed after 8-9 hours. In children, the dose is halved.

In patients with impaired renal function (creatinine clearance from 15 to 40 ml/min), the interval between doses is increased to 12 hours, in the end stage of chronic renal failure (creatinine clearance).

When a child is very ill, only a competent doctor can help. If you're lucky, the child will get away with several doses of antiviral drugs. If the doctor has even the slightest concern about possible complications, he will most likely prescribe an antibiotic.

Recently, according to the Ministry of Health, seasonal “sores” have mutated and become more severe, especially in children aged 2-3 years. It is at this time that children begin to attend kindergarten, actively explore the world, and communicate with peers. And there is fertile ground for the mutual exchange of bacteria. As a result, my mother has to go on sick leave with enviable regularity.

What diseases most often afflict a little person? Local pediatricians know exactly the answer to this question. The most common among children in winter and in the off-season are bronchitis, sore throat, pharyngitis, various forms of otitis media, and tonsillitis. If a child has rolled on an ice slide or skating rink, another problem may occur - hypothermia often causes inflammation of the genitourinary system. The doctor’s conclusion then sounds different - cystitis, pyelonephritis. Children often suffer from intestinal diseases (they are usually “brought” from kindergarten). There is an exit. In all these unpleasant cases, the modern broad-spectrum antibiotic Amosin effectively helps.

What it is?

Let's try to talk about this in simple language. If your child is reluctant to take this drug now, read this and then tell him the story about the courageous defender of all sick children, Amosin. Believe me, you will no longer have to persuade your baby to take the next dose. He will happily take the medicine himself.

So, Amosin 250 is a modern broad-spectrum antibiotic. It is closely related to semisynthetic penicillins. He works like riot police - quickly and decisively. The active ingredient is amoxicillin. Its target is harmful microbes of various origins. The drug enters the body, after 15-20 minutes it penetrates the cell of the harmful bacterium and reduces the speed of all chemical processes that occur in it. Destroys the structure, membrane, enzymes.

The “evil” cell also wants to live, it begins to actively resist and, as a result, wastes its last strength. Amosin is adamant. Its action lasts up to 8 hours. Some “enemy” cells try to attack it with acid. But the valiant antibiotic is resistant to it. That’s why he wins 100% of the time. It is eliminated from the body quite quickly, with the formation of inactive metabolites. This means that the decomposition products are not toxic.

In addition to otitis media, bronchitis and a host of other colds, the remedy successfully copes with such “serious” competitors as sinusitis, salmonellosis and meningitis. Deals with skin infections. Most often, the drug is recommended specifically for sore throat, since this disease is caused by bacteria of various types.

Instructions for use

“Amosin 250” comes in different forms: powder, granules. There is a solution for intramuscular and intravenous use. But for children, the drug is most often prescribed in tablets. Children aged 2-3 years are usually recommended to take an antibiotic in the form of a suspension. It is easy to drink, it has a pleasant taste and smell due to the vanillin added by the manufacturer to the main composition. Amosin is not available in syrup form.

The drug in the form of a suspension is the optimal choice for a child 2-3 years old

The dosage is determined by the doctor. It depends on the age of the child. "Amosin 250" can be given even to newborns from the first days of life.

Parents will have to prepare the suspension for children themselves. To do this, the powder is simply added to cooled boiled water. “Amosin 125” (a drug containing 125 mg of active ingredient) should be diluted in 2.5 ml. water. For a 250 mg product you will need 5 ml of water respectively. For 500 mg - 10 ml. liquids.

The dosage and schedule of administration are usually as follows.

• Children from birth to 2 years: three times a day. The general daily dosage is 20 mg of suspension per kilogram of patient weight.
• Preschool children up to 5 years old inclusive can take 125 mg. suspensions three times a day.
• Children from 5 to 10 years old: three times a day, 250 mg.
• Schoolchildren over 10 years old 500 mg of Amosin also three times a day.

Tablets and capsules of the drug are not given to children under 2 years of age!

Sometimes Amosin is prescribed to children to prevent endocarditis or surgical infection. In this case, doctors recommend starting with half the adult dose.

The dosage of Amosin 250 is chosen only by the doctor after examining the child. Contraindications

Be sure to tell the doctor prescribing Amosin to your child if your baby has at least one of these diseases:

• allergic diathesis;
• allergy to flowering (hay fever);
• bronchial asthma;
• liver failure;
• kidney diseases;
• frequently recurring bleeding.

All these diagnoses are a strict contraindication to taking this antibiotic.

The drug should also not be taken by children who have ever had colitis or are allergic to antibiotics.

Amosin 250 affects and destroys various types of bacteria Side effects

Do not forget that, like any powerful antibiotic, the drug can cause side effects. The instructions for use describe the following symptoms:

• gastrointestinal disorders;
• nausea;
• allergic rhinitis;
• the appearance of rash and itching;
• shortness of breath, sleep disturbance, depression of the central nervous system, tearfulness of the child.

If your son or daughter has any of the above, be sure to tell your doctor - he will adjust the dosage and give the necessary recommendations.

Overdose

If it so happens that the child took a dose of the drug exceeding that prescribed by the doctor, carefully monitor him. An ambulance should be called if symptoms such as nausea, severe vomiting, abdominal pain, or dizziness appear. Only emergency specialists can help in this situation, because a powerful antibiotic acts quickly, and there is simply no antidote to it. Doctors will promptly rinse the stomach with saline solution and relieve intoxication in the body. Self-medication in this case is extremely dangerous.

"Amosin" is more than affordable. Its average cost in Russian pharmacies is about 70 rubles (sachets for preparing a suspension), 27-40 rubles (tablets). The drug in capsules costs just over 60 rubles. Prices in different regions of the country and pharmaceutical chains may differ, although only slightly.

Amosin tablets and capsules are not given to children under 2 years of age. Shelf life and storage conditions

The drug should be stored in a place protected from moisture and direct sunlight, at a temperature no higher than +25C and no lower than +15C, for no more than 2 years from the date of manufacture. The drug is released strictly according to prescription.

Amosin 250 is a domestically produced antibiotic. Manufacturer: pharmaceutical company Sintez AKO OJSC (Kurgan region).

The situation with analogues is quite interesting. Usually the original drug is more expensive than its analogues. But here it's the other way around. Drugs with similar effects are:

Flemoxin Solutab. Produced in Holland. A package of tablets (20 pieces) costs more than 300 rubles.

Augmentin. A bacterial antibiotic originally from England. A package of tablets (20 pieces) costs more than 250 rubles. By the way, pediatricians often like to prescribe Augmentin to their patients. In order not to overpay, it makes sense for parents to check with the doctor whether it can be replaced with our original “Amosin”, which costs almost 5 times less.

Amoxiclav. Another drug with a similar effect. Produced in Slovenia. It costs more than other analogues. For a package of 14 tablets you will have to pay 250 rubles.

Reviews

On the Internet, the drug Amosin is known and most often approved. Since doctors have recently begun to prescribe it more often, parents already have some experience using the antibiotic to treat children. The majority of those who have published their impressions of the medication emphasize that the main advantage of the drug is its speed of action. On the very first day after starting treatment, the child’s temperature drops, and after 5-6 days the baby is healthy. Mothers cannot but be happy about this, since they have to spend less time on sick leave. Almost everyone notes that this is a worthy alternative to expensive imported drugs.

Some parents note that their children have stomach pain and digestion problems during treatment with Amosin. In this case, remedies for restoring intestinal microflora, such as “Bifidumbacterin”, “Lactiale”, etc., can be saved. They will also be prescribed by a doctor.

Only a small proportion of mothers and fathers complain of sleep disturbances in their children while taking antibiotics. And only a few experienced side effects from the drug.

Some parents avoid taking antibiotics at all costs, even if their doctor strongly recommends them. But when prescribed by a doctor, you should not be afraid of them.

Helping the child overcome the disease as quickly as possible is the main task of caring parents. And when the child is healthy again, life in the house returns to normal, with its little joys and daily childhood discoveries. Let the kids smile!

You can learn even more about antibiotics from Dr. Komarovsky’s program.

Instructions for the use of amosin tablets, description of the action of the drug, indications for the use of amosin tablets, interactions with other drugs, use of amosin (tablets) during pregnancy. Instructions:

Amosin powder

Composition of amosin tablets

One tablet contains

Bir tabletkan kuramynda

Active substance amosin

amoxicillin trihydrate (in terms of amoxicillin) 250 mg, 500 mg

amoxicillin trihydrates (amoxicilling shakanda) 250 mg, 500 mg

Excipients in amosine

potato starch, magnesium stearate, talc, povidone, calcium stearate

potato starches, magnesium stearates, talc, povidone, calcium stearates

Indications for the use of amosin tablets

• bronchitis, pneumonia

• sinusitis, pharyngitis, tonsillitis, acute otitis media

• pyelonephritis, pyelitis, cystitis, urethritis, gonorrhea, endometritis, cervicitis

• cholangitis, cholecystitis, dysentery, salmonellosis, salmonella carriage

• erysipelas, impetigo, secondary infected dermatoses

• leptospirosis

• listeriosis

• Lyme disease (borreliosis)

• endocarditis (prevention)

• bronchitis, pneumonia

• sinusitis, pharyngitis, tonsillitis, otitis media

• pyelonephritis, pyelitis, cystitis, urethritis, soz, endometritis, cervicitis

• cholangitis, cholecystitis, dysentery, salmonellosis, salmonellosis tasymaldaushylykta

• tone, impetigo, enlarged dermatosis

• leptospirosis

• listeriosis

• Lyme aurynda (borreliosis)

• endocarditis (aldyn alu)

Contraindications for amosin tablets

• hypersensitivity to the drug (including other penicillins, cephalosporins, carbapenems)

• children under 6 years of age (for this dosage form)

• lactation period

• drug (son ishіnde baska penicillinderge, cephalosporinderge, carbapenemderge) asa zhogary sezimtaldyk

• 6 zhaska deyingі balalarga (os darilik tur ushin)

• Kezeni lactation

Side effects of amosin tablets

• dysbacteriosis, change in taste, stomatitis, glossitis, vomiting, nausea, diarrhea, moderate increase in the activity of “liver” transaminases

• pseudomembranous enterocolitis

• agitation, anxiety, insomnia, ataxia, confusion, behavior changes, depression, peripheral neuropathy, headache, dizziness, epileptic reactions

• leukopenia, neutropenia, thrombocytopenic purpura, anemia

• urticaria, skin hyperemia, erythematous rashes, angioedema, rhinitis, conjunctivitis; rarely - fever, arthralgia, eosinophilia, exfoliative dermatitis, exudative erythema multiforme (including Stevens-Johnson syndrome), reactions similar to serum sickness, very rarely - anaphylactic shock

• other: vaginal candidiasis, difficulty breathing, tachycardia, interstitial nephritis, superinfection (especially in patients with chronic diseases or reduced body resistance)

• dysbacteriosis, ladies sezudin ozgeruі, stomatitis, glossitis, zhurek ainu, kusu, diarrhea, “bauyr” transaminasalary belsendilіgіnіn ortasha zhogarylauy

• zhalgan zhargashaly enterocolitis

• kozu, ureilenu, ұyқysyzdyk, ataxia, sananѣ shatasuy, minez-құlyқ өzgeruі, depression, shetkergі neuropathy, bass aura, bass ainalu, epilepsy reaction.

• leukopenia, neutropenia, thrombocytopenia purpura, anemia

• esekzhem, teri hyperemias, erythematoses bortpeler, angioneurotics, rhinitis, conjunctivitis; sirek: kyzba, arthralgia, eosinophilia, exfoliative dermatitis, multiformal exudative erythema (synthesis of Stevens-Johnson syndromes), sarysu kuyu auruyn ұқсас reactionlar, ote sirek — anaphylactic shock

• bascalars: kynaptyk candidiasis, tynystyn taryluy, tachycardia, interstitial nephritis, askin zhukpa (asіrese, sozylmaly aurular bar nemese organism tözіmdіlіgі tomendegen emdelushilerde)

Special instructions for use

With caution: allergic diseases (including a history), a history of gastrointestinal diseases (especially colitis associated with the use of antibiotics), renal failure, severe liver dysfunction, infectious mononucleosis, lymphocytic leukemia.

During a course of treatment, it is necessary to monitor the state of the function of the hematopoietic organs, liver and kidneys.

It is possible that superinfection may develop due to the growth of microflora that is insensitive to it, which requires a corresponding change in antibacterial therapy.

When prescribed to patients with sepsis, a bacteriolysis reaction (Jarisch-Herxheimer reaction) may develop (rarely).

In patients who are hypersensitive to penicillins, cross-allergic reactions with other beta-lactam antibiotics are possible.

When treating mild diarrhea during a course of treatment, antidiarrheal drugs that reduce intestinal motility should be avoided; You can use kaolin- or attapulgite-containing antidiarrheal agents. If diarrhea is severe, consult a doctor.

Treatment must continue for another 48-72 hours after the disappearance of clinical signs of the disease. When using estrogen-containing oral contraceptives and amoxicillin simultaneously, other or additional methods of contraception should be used.

Pregnancy and lactation

The use of the drug during pregnancy is possible when the expected benefit to the mother outweighs the potential risk to the fetus. If it is necessary to prescribe the drug during lactation, breastfeeding should be stopped.

Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous mechanisms

There have been no reports of the effects of amoxicillin on driving or using machinery. However, some patients may experience headache and dizziness. If they occur, the patient must take special precautions when driving and operating machinery.

Saktykpen: allergy aurular (sons іshіnde syrtartkydagy), syrtartkydagy askazan-ishek zholy aurulary (asіrese, antibiotic qoldanumen baylanysty colitis), buyrek zhetkіlіksіzdіgі, bauyr functionson auyr buzyluy, zhuқpaly mononucleosis, lymphocytic leukemia.

Kurstyk emdeude kan tuzu agzalarynyn, bauyr zhane buyrek functionson zhagdayyn bakylap otyru kazhet.

During the season, the microflora is determined as a result of the damage caused by bacteria and bacteria.

Sepsispen naukastarga tagaiyndalganda bacteriolysis reactionlarynyn (Yarish-Herxheimer reactions) ladies mүmkin (sirek).

Penicillinderge zhogary sezimtaldygy bar emdelushilerde baska beta-lactams antibiotictermen aykaspali allergylyk reactionlar boluy mumkin.

Kurstyk emdeu ayasynda zhenіl diarrheaany emdegende ishek peristalsisyn tomendetetіn diarrhea karsy drugtardan aulak bolu kerek; kuramynda kaolin nemese attapulgit bar diarrhea karsy dәrіlerdi paydalanuga bolady.

Auyr diarrhea dәrigerge karalu kazhet.

Emdeu aurudyn klinikalyk belgіleri basylgannan keyin mіndetti tүrdе tags 48-72 сағат злғади.

Kuramynda estrogen bar ishuge arnalgan contraceptiveter men amoxicillin bir mezgilde koldanylganda mukkindiginshe baska nemes kosymsha contraception adisterin paydalan kerek.

Zhuktilik zhane lactation case

The product should be used for the preparation of the product.

Please close the knob without changing the mechanism of the car.

Amoxicillinn autocolic baskaruga nemes mekhanizdermen zhumys isteuge aser etui zhoninde khabarlamalar bolmagan. Degenmen de, keibir emdelushilerde bas auyru zhane bas ainalu boluy mumkin. Olar bіlіngende emdelushi avtokolik baskarganda zhane mekhanizdermen zhumys istegende erekshe saktan sharalaryn kadagalauy tisіs.

Dosage and method of administration

Orally, taken regardless of meals. The tablet can be swallowed whole, split into pieces, or chewed with a glass of water.

Adults and children over 10 years old(with body weight more than 40 kg) prescribed 500 mg 3 times a day; for severe infection - 750-1000 mg 3 times a day.

Children aged 6-10 years prescribed 250 mg 3 times a day; for severe infection – 60 mg/kg/day 3 times a day. The course of treatment is 5-12 days.

For acute uncomplicated gonorrhea prescribe 3000 mg once; When treating women, it is recommended to re-take the indicated dose every other day.

For acute infectious diseases of the gastrointestinal tract(paratyphoid fever, typhoid fever) and biliary tract, for gynecological infectious diseases in adults - 1500-2000 mg 3 times a day or 1000-1500 mg 4 times a day.

For leptospirosis adults – 500-750 mg 4 times a day for 6-12 days.

In case of salmonella carriage adults – 1500-2000 mg 3 times a day for 2-4 weeks.

For the prevention of endocarditis during minor surgical interventions adults – 3000-4000 mg 1 hour before the procedure. If necessary, a repeat dose is prescribed after 8-9 hours. In children, the repeat dose is reduced by 2 times.

In patients with impaired renal function with CC 15-40 ml/min, the interval between doses is increased to 12 hours; when CC is below 10 ml/min, the dose is reduced by 15-50%; for anuria - maximum dose 2000 mg/day.

Ishke, as ishuge baylanyssyz kabyldanady. The tablets in the glass will not be washed out, but there will be no more heat.

Eresekterge zhane 10 zhastan ulken (den salmagy 40 kg-den kop) balalarga tauligine 3 ret 500 mg tagayindalada; zhukpanyn auyr agymynda – tauligine 3 ret 750-1000 mg.

6-10 times balalarga tauligine 3 ret 250 mg-day tagayindalady; zhukpanyn auyr agymynda – tauligine 3 ret 60 mg/kg/taulik. Emdeu courses 5-12 kun.

Zhedel askynbagan soz kezinde bir ret 3000 mg tagayindalada; ayelderdi emdegende korsetilgen dose kunara kayta kabyldau usynlady.

Askazan-ishek zholynyn (paratifter, ish suzegi) zhane ot shygaru zholdarynyn zhedel zhukpaly aurularynda, gynecology zhukpaly aurularda eresekterge – tәulіgіne 3 ret 1500-2000 mg non-monthly Uligine 4 ret 1000-1500 mg.

Leptospirosis heresekterge – 6-12 kun battles tauligine 4 ret 500-750 mg.

Salmonella tasymaldaushylykta erekterge – 2-4 apta battles tauligine 3 ret 1500-2000 mg.

Shagyn surgery aralasularda endocarditis aldyn alu ushin eresekterge – emshara zhasaluynan 1 sagat buryn 3000-4000 mg. It seems like bolsa, 8-9 saғattan son kaytalau doses tagayyndalady. Balalarda kaytalau dozasyn 2 ese azaytady.

BUYREK FUNCTIONS BUZYLGAN EMDELUSHILERDE QC 15-40 ml/min CC 10 ml/min tomen bolganda dosed 15-50% azaitada; anuriyada – eng zhogary doses 2000 mg/taulik.

Drug interactions

Antacids, glucosamine, laxatives, food, aminoglycosides slow down and reduce absorption; ascorbic acid increases absorption.

Bactericidal antibiotics (including aminoglycosides, cephalosporins, vancomycin, rifampicin) have a synergistic effect; bacteriostatic drugs (macrolides, chloramphenicol, lincosamides, tetracyclines, sulfonamides) - antagonistic.

Increases the effectiveness of indirect anticoagulants (suppressing intestinal microflora, reduces the synthesis of vitamin K and the prothrombin index); reduces the effectiveness of estrogen-containing oral contraceptives; drugs, during the metabolism of which para-aminobenzoic acid is formed, ethinyl estradiol - the risk of developing “breakthrough” bleeding.

Amoxicillin reduces the clearance and increases the toxicity of methotrexate; enhances the absorption of digoxin.

Diuretics, allopurinol, oxyphenbutazone, phenylbutazone, nonsteroidal anti-inflammatory drugs, and other drugs that block tubular secretion increase the concentration of amoxicillin in the blood.

Allopurinol increases the risk of developing skin rashes.

Antacidter, glucosamine, ish zhurgіzgіsh dаrіlіk zattar, tamak, aminoglycosider sіnіrіluіn bayaulatady zаne tomendetedі; Ascorbine kyshkyly sіnіrіluіn artyrady.

Bactericidal antibiotic (containing aminoglycosider, cephalosporinder, vancomycin, rifampicin) synergist; bacteriostatics darilik zattar (macrolider, chloramphenicol, lincosamide, tetracyclinder, sulfanilamide) antagonist aser korsetedi.

Tikeley emes anticoagulanttar tiimdiligin arttyrady (ishek microflorasyn basedetumen, K vitamin synthesis zhane prothrombin indexin tomendetedi); kuramynda estrogen bar ishuge arnalgan contraceptive terdine; Metabolism of para-aminobenzoic derides in the form of para-aminobenzoic acid, ethinyl estradiol in thiimdiligin azaytady – “kuyylgan” kan ketulerdin lady kaupi.

Amoxicillin methotrexattyn clearance azaytyp, uyttylygyn arttyrady; Digoxin is syncotic.

Diureticter, allopurinol, oxyphenbutazone, phenylbutazone, kabynuga karsy steroids emes preparattar zhane ozekshelik secretion bogeytin baska da darilik zattar kananda kandy amoxicillin concentration son zhogarylatada.

Allopurinol teri bortpesinin damu kaupin arttyrady.

Overdose of amosin tablets

Symptoms: nausea, vomiting, diarrhea, water and electrolyte imbalance (as a result of vomiting and diarrhea).

Treatment: gastric lavage, activated carbon, saline laxatives, medications to maintain water and electrolyte balance; hemodialysis.

Symptoms: zhurek ainu, kusu, diarrhea, su-electrolyte tengerimіnіn byzyluy (kusu zhane diarrhea saldarynan).

Emi: askazandy shayu, belsendirilgen komir, tuzdy ish zhurgizgishter su-electrolyte tengerimin saktap turuga arnalgan darylik zattar; hemodialysis.

Pharmacological properties

Pharmacokinetics

Absorption is fast, high (93%), food intake does not affect absorption, and is not destroyed in the acidic environment of the stomach. When taken orally at a dose of 125 and 250 mg, the maximum concentration is 1.5-3 and 3.5-5 mcg/ml, respectively. The time to reach maximum concentration after oral administration is 1-2 hours.

It has a large volume of distribution: found in high concentrations in plasma, sputum, bronchial secretions (in purulent bronchial secretions the distribution is weak), pleural and peritoneal fluid, urine, the contents of skin blisters, lung tissue, intestinal mucosa, female genital organs, prostate gland, fluid of the middle ear (with inflammation), bone, adipose tissue, gall bladder (with normal liver function), fetal tissue. When the dose is doubled, the concentration also doubles.

The concentration in bile exceeds the concentration in plasma by 2-4 times. In the amniotic fluid and umbilical cord vessels, the concentration of amoxicillin is 25-30% of the level in the plasma of a pregnant woman. It penetrates poorly through the blood-brain barrier, but with inflammation of the meninges, the concentration in the cerebrospinal fluid is about 20% of the level in plasma. Communication with plasma proteins - 17%. Partially metabolized to form inactive metabolites. The half-life is 1-1.5 hours. It is excreted 50-70% by the kidneys unchanged (by tubular secretion - 80% and glomerular filtration - 20%), by the liver - 10-20%. A small amount is excreted in breast milk. If renal function is impaired (creatinine clearance (CC) less than or equal to 15 ml/min), the half-life increases to 8.5 hours.

Amoxicillin is removed by hemodialysis.

Siniriloui – zhyldam, zhoghary (93%), as ishu siniriliuyne ykpalyn tigizbayda, kashkyldy ortasynda ydyramaida. 125 mg or 250 mg dosage іshke kabyldaganda eng zhogary concentrations, lower, 1.5-3 μg/ml or 3.5-5 μg/ml. Ishu arkyly kabyldagannan kein en zhogary concentration son zhetu uakyty – 1-2 sagat.

Taralu kolemi ulken: zhogary concentrationlard plasmadan, qakyryktan, bronchial secretion (irindi bronchial secretion taraluy alsiz), pleuralyk zhane peritonealdi suyyktyktan, nesepten, teri kuldire uikterin іshіndegіsіnen, okpe tіndіnen, іshektіn shiryshty kabygynan, ayeldin zhynys azalarynan, kuyk asty bezіnen, ortangy kulak s ұyyқtyғynan ( ol kabynganda), suyekten, may tinіnen, ot kabynan (kalypts bauyr functionsonda), yurk tinderinen tabylada. Doses 2 esege arttyrganda concentrations and 2 ese ulgayady.

èttegi concentrations plasmads concentration synan 2-4 ese asyp ketedi. Amnioticalyk sұyyқtykta zаne qіndіk tamyrlarynda amoxicillin concentrations – zhүkti әyel plasmasyndagy degheidin 25-30%. Hematoencephaladyk boget arkyly nashar otedі, mi kabyktarynyn kabynuynynd zhulyn suyyyktygyndagy concentrations – plasmas dengeyinen 20% zhuyk. Plasma akuyzdarymen baylanysy – 17%. Belsendi emes metabolite tuzumen ishinara metabolizdenedi. Zhartylay shygarylu kezen – 1-1.5 sagat.

Ozgerissiz kүyde buyrekpen 50-70% (ozekshelik secretion zholymen — 80% zhane shumaktyk suzіlister arkyly — 20%), bauyrmen 10-20% shygarylada. Azdağan molsherde ana sүtimen bolіnedi. Buyrek functionson buzyluynda (creatinine clearance (CC) 15 ml/minute az nemese ogan ten) zhartylay shygarylu kezeng 8.5 sagatka deyin uzarada. Amoxicillin hemodialysis kezinde shygarylada.

Pharmacodynamics

Amosin® is a broad-spectrum bactericidal antibiotic from the group of semisynthetic penicillins. It disrupts the synthesis of peptidoglycan (the supporting polymer of the cell wall) during division and growth, causing lysis of bacteria.

Active against: aerobic gram-positive microorganisms: Staphylococcus spp. (except for penicillinase-producing strains), Streptococcus spp. and aerobic gram-negative microorganisms: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Shigella spp., Salmonella spp., Klebsiella spp. Strains producing penicillinase are resistant to amoxicillin.

Amosin® is a hot synthetic penicillinder tobyndagy aser etu aukymy ken bactericidal antibiotic. Bolina zhane osu keseninde peptidoglycan (zhasusha kabyrgasynyn terek polymeri) syntezin buzada, bacterium lysisin tudyrady. Aerobts gramon microorganism: Staphylococcus spp. (penicillinase Ondiretin strains of kospaganda), Streptococcus spp. female aerobtes gramteris microorganism: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Shigella spp., Salmonella spp., Klebsiella spp. katysty belsendi. Penicillinase ondiretin strain amoxicillin aserine tozimdi.

Packaging and release form

Tablets 250 mg, 500 mg. 10 tablets in a blister pack made of polyvinyl chloride film and printed varnished aluminum foil. 1 blister pack with instructions for medical use in the state and Russian languages ​​is placed in a cardboard pack.

250 mg, 500 mg tabletkalar. 10 tablets polyvinyl chloride containing baspaly lactalgan aluminum foil jasalgan pishindi yashykty kaptamada. 1 pіshіndі ұяшықты қaptamadan medicinada qoldanyluy zhөnіndegі memlekettіk zhane orys tіlderіndegi nұskaulykpen birge cardboard pashkege salads.

Country of origin

Product group

Broad-spectrum penicillin antibiotic, destroyed by penicillinase

Release forms

• 1.5 g - single-dose packages (10) - cardboard packs. 10 - blister packs (1) - cardboard packs 10 - blister packs (2) - cardboard packs 60 g (5 g amoxicillin) - dark glass jars (1) complete with a dosing spoon - cardboard packs. 60 g (5 g of amoxicillin) - polyethylene bottles (1) complete with a dosage spoon - packs of Powder for the preparation of a suspension for oral administration 250 mg/5 ml; powder for the preparation of suspension for oral administration 500 mg.

Description of the dosage form

• Capsules Powder Powder for the preparation of a suspension for oral administration, white with a yellowish tint, with a specific odor; the prepared suspension is white with a yellowish tint, with a specific odor. Tablets are white or almost white, flat-cylindrical, with a chamfer and a score. Tablets are white or almost white, flat-cylindrical, with a chamfer and a score.

pharmachologic effect

Pharmacokinetics

Special conditions

Compound

• 5 ml of ready-made suspension. 1 can of amoxicillin (in the form of trihydrate) 250 mg 5 g Excipients: polyvinylpyrrolidone (povidone), dextrose, sodium edetate (disodium salt of ethylenediaminetetraacetic acid (Trilon B)), sodium disubstituted phosphate, sodium glutamate monohydrate, food flavoring, vanillin, sucrose. amoxicillin (in the form of trihydrate) 250 mg Excipients: polyvinylpyrrolidone (povidone), glucose (dextrose), Trilon B (disodium edetate), sodium disubstituted phosphate (sodium hydrogen phosphate), sodium?-glutamate monohydrate, food flavoring, vanillin, sucrose. amoxicillin (in trihydrate form) 250 mg Excipients: potato starch, magnesium stearate, calcium stearate, magnesium hydrosilicate (talc), povidone (kollidon 90F). amoxicillin (in trihydrate form) 500 mg Excipients: potato starch, magnesium stearate, calcium stearate, magnesium hydrosilicate (talc), povidone (kollidon 90F). amoxicillin (in trihydrate form) 250 mg Excipients: potato starch. Ingredients of gelatin capsules: titanium dioxide, methylhydroxybenzoate, propylhydroxybenzoate, acetic acid, gelatin. amoxicillin trihydrate (in terms of amoxicillin) - 0.500g Excipients: polyvinylpyrrolidone (povidone), glucose (dextrose), disodium ethylenediamine salt N,N,N,N"-tetraacetic acid 2-water (trilon B) (disodium edetate) , sodium phosphate disubstituted (sodium hydrogen phosphate), sodium a-glutamic acid 1-water, food flavoring, vanillin, sugar (sucrose).

Amosin indications for use

• Infectious and inflammatory diseases caused by microorganisms sensitive to the drug: - respiratory infections (including bronchitis, pneumonia); - infections of the ENT organs (including sinusitis, pharyngitis, tonsillitis, acute otitis media); - infections of the genitourinary system (including pyelonephritis, pyelitis, cystitis, urethritis, gonorrhea); - gynecological infections (including endometritis, cervicitis); - infections of the gastrointestinal tract (including peritonitis, enterocolitis, typhoid fever, cholangitis, cholecystitis); - infections of the skin and soft tissues (including erysipelas, impetigo, secondary infected dermatoses); - leptospirosis; - listeriosis; - Lyme disease (borreliosis); - dysentery; - salmonellosis, salmonella carriage; - meningitis; - endocarditis (prevention); - sepsis.

Amosin contraindications

• Infectious mononucleosis, lymphocytic leukemia, severe gastrointestinal infections accompanied by diarrhea or vomiting, respiratory viral infections, allergic diathesis, bronchial asthma, hay fever, hypersensitivity to penicillins and/or cephalosporins. For use in combination with metronidazole: diseases of the nervous system; hematopoietic disorders, lymphocytic leukemia, infectious mononucleosis; hypersensitivity to nitroimidazole derivatives. For use in combination with clavulanic acid: a history of liver dysfunction and jaundice associated with taking amoxicillin in combination with clavulanic acid.

Amosin dosage

• 0.25 g, 0.5 g

Amosin side effects

• Allergic reactions: possible - urticaria, skin hyperemia, erythema, angioedema, rhinitis, conjunctivitis; rarely - fever, joint pain, eosinophilia, exfoliative dermatitis, erythema multiforme, Stevens-Johnson syndrome, reactions similar to serum sickness; in isolated cases - anaphylactic shock. From the digestive system: dysbacteriosis, change in taste, vomiting, nausea, diarrhea, stomatitis, glossitis, liver dysfunction, moderate increase in the activity of liver transaminases; rarely - pseudomembranous enterocolitis. From the central nervous system and peripheral nervous system: agitation, anxiety, insomnia, ataxia, confusion, behavior changes, depression, peripheral neuropathy, headache, dizziness, convulsive reactions. From the urinary system: rarely - interstitial nephritis. From the hematopoietic system: leukopenia, neutropenia, thrombocytopenic purpura, anemia. Other: difficulty breathing, tachycardia, vaginal candidiasis, superinfection (especially in patients with chronic diseases or reduced body resistance).

Drug interactions

Overdose

Storage conditions

• keep away from children

Synonyms

• Amine, Amoxicar, Amoxillat, Amoxillat-250, Amoxicillin, Amoxicillin Watham, Amoxicillin trihydrate, Amoxicillin-Ratiopharm, Amoxicillin-Ratiopharm 250 TC, Amoxicillin-Teva, Amoxicillin sodium salt sterile, Amoxicillin trihydrate, Amoxone, Am

APPROVED

By order of the Chairman of the Committee

Control of medical and

Pharmaceutical activities

Ministry of Health

Republic of Kazakhstan

From "____"___________20 __year

№__________________________

Instructionsfor medical use

medicine

AMOSIN®

Tradename

International nonproprietary name

Amoxicillin

Dosage form

Powder for oral suspension, 125 mg, 250 mg and

Compound

One single dose package contains

active substance- amoxicillin trihydrate (in terms of amoxicillin) - 0.125 g, 0.250 g or 0.500 g,

Excipients: povidone, dextrose, disodium edetate, sodium hydrogen phosphate, sodium α-glutamic acid 1-water, food flavoring, vanillin, sucrose.

Description

White powder with a yellowish tint, with a specific odor. The finished suspension is a suspension of white color with a yellowish tint, with a specific odor

Pharmacotherapeutic group

Beta-lactam antibacterial drugs, penicillins.

PBX code J01CA04

Pharmacological properties

Pharmacokinetics

When taken orally, amoxicillin is rapidly absorbed with a bioavailability of 93%. At a dose of 125 mg and 250 mg, the maximum concentration in blood plasma is 1.5-3 mcg/ml and 3.5-5 mcg/ml, respectively. The time to reach maximum concentration in blood plasma after oral administration is 1-2 hours. It has a large volume of distribution - high concentrations are found in blood plasma, sputum, bronchial secretions (distribution is weak in purulent bronchial secretions), pleural and peritoneal fluid, urine, skin contents blisters, lung tissue, intestinal mucosa, female genital organs, prostate gland, middle ear fluid, bone, adipose tissue, gallbladder (if liver function is normal), fetal tissue. When the dose is doubled, the concentration also doubles. The concentration in bile exceeds the concentration in blood plasma by 2-4 times. In the amniotic fluid and umbilical cord vessels, the concentration of amoxicillin is 25-30% of the level in the blood plasma of a pregnant woman. It penetrates the blood-brain barrier poorly; in case of inflammation of the meninges (meningitis), the concentration in the cerebrospinal fluid is about 20%. Communication with blood plasma proteins - 17%.

Partially metabolized to form inactive metabolites. The half-life is 1-1.5 hours. It is excreted 50-70% unchanged by the kidneys through tubular excretion (80%) and glomerular filtration (20%), and by the liver - 10-20%. A small amount is excreted in breast milk. The half-life in premature infants, newborns and children under 6 months is 3-4 hours. If renal function is impaired (creatinine clearance is less than or equal to 15 ml/min), the half-life increases to 8.5 hours. Amoxicillin is removed by hemodialysis. The effect of the drug develops 15-30 minutes after administration and lasts 8 hours.

Pharmacodynamics.

Amosin is a broad-spectrum bactericidal antibiotic from the group of semisynthetic penicillins. It disrupts the synthesis of peptidoglycan (the supporting polymer of the cell wall) during division and growth, causing lysis of bacteria. Active against aerobic gram-positive microorganisms: Staphylococcus spp. (except for penicillinase-producing strains), Streptococcus spp. and aerobic gram-negative microorganisms: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Shigella spp., Salmonella spp., Klebsiella spp. Strains producing penicillinase are resistant to amoxicillin.

Indications for use

Bronchitis, pneumonia

Sinusitis, pharyngitis, tonsillitis, acute otitis media

Pyelonephritis, pyelitis, cystitis, urethritis, gonorrhea, endometritis, cervicitis

Dysentery, salmonellosis, salmonella carriage, cholangitis, cholecystitis

Erysipelas, impetigo, secondary infected dermatoses

Leptospirosis, listeriosis, Lyme disease (borreliosis), endocarditis (prevention)

Directions for use and doses

Inside, before or after meals.

Adults and children over 10 years old(with body weight more than 40 kg) prescribed 0.5 g 3 times a day; for severe infection - 0.75 -1 g 3 times a day.
Children aged 5-10 years prescribed 0.25 g 3 times a day; 2-5 years - 0.125 g 3 times a day;
under 2 years old- 20 mg/kg 3 times a day. For acute infectious diseases of the gastrointestinal tract (paratyphoid fever, typhoid fever) and biliary tract, for gynecological infectious diseases for adults - 1.5-2 g 3 times a day or 1-1.5 g 4 times a day. The course of treatment is 5-12 days.

For acute uncomplicated gonorrhea, 3 g is prescribed once; When treating women, repeated administration of the indicated dose is recommended.

For leptospirosis in adults - 0.5-0.75 g 4 times for 6-12 days.

For salmonella-carrying adults - 1.5-2 g 3 times a day for 2-4 weeks.

For the prevention of endocarditis during minor surgical interventions for adults - 3-4 g 1 hour before the procedure. If necessary, a repeat dose is prescribed after 8-9 hours. In children, the dose is halved.

In patients with impaired renal function with a creatinine clearance of 15-40 ml/min, the interval between doses is increased to 12 hours; when creatinine clearance is below 10 ml/min, the dose is reduced by 15-50%; for anuria - maximum dose 2 g/day.

Preparation of the suspension.

Single dose package

Boiled and cooled water is poured into a clean glass (see table), then the contents of one packet are poured out and mixed until a homogeneous suspension is obtained.

Dose in package, instant required amount of water, ml

125 2.5 (1 teaspoon)

2505 (2 teaspoons)

50010 (4 teaspoons)

Use strictly as prescribed by your doctor.

Side effects

Urticaria, skin flushing, erythema, angioedema, rhinitis, conjunctivitis

Dysbacteriosis, change in taste, vomiting, nausea, diarrhea, stomatitis, glossitis, liver dysfunction, moderate increase in the activity of “liver” transaminases, pseudomembranous enterocolitis

Vaginal candidiasis

Fever, joint pain, eosinophilia, exfoliative dermatitis, erythema multiforme, Stevens-Johnson syndrome, reactions similar to serum sickness

Agitation, anxiety, insomnia, ataxia, confusion, behavior changes, depression, peripheral neuropathy, headache, dizziness, seizures

Leukopenia, neutropenia, thrombocytopenic purpura, anemia

Difficulty breathing, tachycardia, interstitial nephritis

Superinfection (especially in patients with chronic diseases or reduced body resistance)

In isolated cases: anaphylactic shock

Contraindications

Hypersensitivity to the components of the drug (including other penicillins, cephalosporins, carbapenems)

Allergic diathesis

Bronchial asthma

Hay fever, infectious mononucleosis, lymphocytic leukemia

Liver failure

History of gastrointestinal diseases (especially antibiotic-associated colitis)

Lactation period

Drug interactions

Antacids, glucosamine, laxatives, aminoglycosides - slow down and reduce the absorption of Amosin; ascorbic acid increases the absorption of Amosin.

Amosin® is not destroyed in the acidic environment of the stomach, food intake does not affect its absorption.

Bactericidal antibiotics (including aminoglycosides, cephalosporins, vancomycin, rifampicin) - have a synergistic effect; bacteriostatic drugs (macrolides, chloramphenicol, lincosamides, tetracyclines, sulfonamides) - antagonistic.

Increases the effectiveness of indirect anticoagulants (suppressing intestinal microflora, reduces the synthesis of vitamin K and the prothrombin index); reduces the effectiveness of estrogen-containing oral contraceptives, drugs whose metabolism produces para-aminobenzoic acid, ethinyl estradiol - the risk of breakthrough bleeding.

Amoxicillin reduces the clearance and increases the toxicity of methotrexate; enhances the absorption of digoxin.

Diuretics, allopurinol, oxyphenbutazone, phenylbutazone, non-steroidal anti-inflammatory drugs; drugs that block tubular secretion increase the concentration of amoxicillin in the blood.

Allopurinol increases the risk of developing skin rashes.

special instructions

It is possible that superinfection may develop due to the growth of microflora that is insensitive to it, which requires a corresponding change in antibacterial therapy.

When prescribed to patients with sepsis, a bacteriolysis reaction (Jarisch-Herxheimer reaction) may develop (rarely).

In patients who are hypersensitive to penicillins, cross-allergic reactions with other beta-lactam antibiotics are possible.

Amosin is a semi-synthetic drug from the group of penicillins with broad-spectrum antibacterial action.

Its effect is manifested in inhibition of the transpeptidase enzyme, disruption of the stability of cell walls, inhibition of the development of pathogenic microorganisms and their division at the cellular level, which ultimately causes lysis of pathogenic microflora.

On this page you will find all the information about Amosin: complete instructions for use for this drug, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Amosin. Would you like to leave your opinion? Please write in the comments.

Clinical and pharmacological group

A broad-spectrum penicillin antibiotic that is destroyed by penicillinase.

Conditions for dispensing from pharmacies

Dispensed with a doctor's prescription.

Prices

How much does Amosin cost? The average price in pharmacies is 30 rubles.

Release form and composition

Amosin is available in several dosage forms.

Amosin gelatin capsules, white, size No. 0. The contents of the capsules are white granules. Packaged in contour cells of 10 pieces.

Amosin tablets are white or almost white, flat cylindrical in shape, with a separating line and a chamfer. Packaged in contour cells of 10 pieces.

Amosin powder for the preparation of a suspension for oral administration has a white color with a yellowish tint and a specific odor. The prepared suspension is white with a yellowish tint and has a specific odor. Packaged in single-dose packages of 1.5; 3 and 6 years

Pharmacological effect

The active component of the medicinal product actively affects gram-negative bacteria - Neisseria meningitidis and Listeria monocytogenes and Bacillus anthracis, Klebsiella spp., Neisseria gonorrhoeae and Helicobacter pylori; for gram-positive staphylococcal and streptococcal bacteria. Pathogenic microflora that produce penicillinase are immune to the effects of the active component Amosin.

The effect of taking the medicinal drug appears in 15-30 minutes and lasts for 8 hours. The medicine is easily and within a short time absorbed by the walls of the gastrointestinal tract, and the presence of food in it does not affect the rate of absorption. The maximum content of amoxicillin is achieved in the blood plasma in the first 1-2 hours. The blood flow carries the active component of the drug to the mucous membranes of organs, bone and connective tissue, intraocular sputum and fluid. The elimination time of the drug through the kidneys averages two to three hours and may increase in patients with impaired renal function.

Indications for use

The antibiotic Amosin is prescribed for bacterial infections:

• Urogenital infections (, pyelitis,);
• Infectious diseases of the digestive tract (dysentery, abdominal type,);
• Borreliosis;
• Acute infectious diseases of the upper respiratory tract;
• Acute infectious diseases of the lower respiratory tract (,);
• Infections of ENT organs (,);
• Diseases of the skin and soft tissues (secondarily infected dermatosis, impetigo,);
• Prevention of endocarditis and surgical infection.

Contraindications

Contraindications to the use of Amosin are:

• Liver failure;
• Bronchial asthma and hay fever;
• Allergic diathesis;
• Lymphocytic leukemia;
• Infectious mononucleosis;
• Diseases of the gastrointestinal tract;
• Hypersensitivity to amoxicillin and other penicillins, as well as carbapenems and cephalosporins;
• Breastfeeding period;
• Children under 3 years of age (for the dosage form in the form of capsules and tablets).

Amosin is prescribed with caution to pregnant women and patients with renal failure and a history of bleeding.

Use during pregnancy and lactation

The use of the drug during pregnancy is possible only in cases where the expected benefit of therapy for the mother outweighs the potential risk to the fetus.

Use during lactation is contraindicated. If use is necessary during lactation, breastfeeding should be stopped.

Instructions for use Amosin

The instructions for use indicate that Amosin is taken orally, before or after meals. The dosage regimen is set individually, taking into account the severity of the disease, the sensitivity of the pathogen to the drug, and the age of the patient.

• Adults and children over 10 years of age (with body weight >40 kg) are prescribed 500 mg 3 times a day, for severe disease - 0.75-1 g 3 times a day.
• Children aged 5 to 10 years are prescribed 250 mg 3 times / day, from 2 to 5 years - 125 mg 3 times / day, for children under 2 years - 20 mg / kg / day in 3 doses. The course of treatment is 5-12 days.
• For children under 5 years of age, the drug is prescribed in the form of a suspension.

For treatment of acute uncomplicated gonorrhea the drug is prescribed in a dose of 3 g once; When treating women, repeated administration of the indicated dose is recommended.

At acute infectious diseases of the gastrointestinal tract (paratyphoid fever, typhoid fever) and biliary tract, for gynecological infectious diseases adults are prescribed 1.5-2 g 3 times a day or 1-1.5 g 4 times a day.

At leptospirosis adults are prescribed 500-750 mg 4 times a day for 6-12 days.

At salmonella carriage adults – 1.5-2 g 3 times a day for 2-4 weeks.

For prevention of endocarditis during minor surgical interventions adults are prescribed a dose of 3-4 g 1 hour before the procedure. If necessary, a repeat dose is prescribed after 8-9 hours. In children, the dose is halved.

In patients with impaired renal function (creatinine clearance from 15 to 40 ml/min), the interval between doses is increased to 12 hours, in the end stage of chronic renal failure (creatinine clearance).<10 мл/мин) дозу Амосина следует уменьшить на 15-50% или увеличить интервал между приемами до 24 ч, при анурии – максимальная доза составляет 2 г/сут.

Powder for the preparation of oral suspension Amosin

The drug is intended for the preparation of a suspension taken orally. The prepared suspension is taken before or after meals.

To prepare a suspension from powder packaged in disposable bags, pour chilled boiled water into a glass, add the contents of the bag and stir until an equilibrium suspension is obtained. The amount of water is measured depending on the dose of amoxicillin in the package (to obtain a suspension containing 250 mg of amoxicillin in 5 ml of suspension). For a dose of amoxicillin in a sachet of 125 mg, take 2.5 ml of drinking water, for a dose of 250 mg - 5 ml of drinking water, for a dose of 500 mg - 10 ml of drinking water. The drug should be taken immediately after preparing the suspension. After taking the drug, the glass should be rinsed in running water and dried.

To prepare a suspension from powder packaged in jars or bottles, measure 62 ml of chilled boiled water and add in parts to the bottle or jar. While adding water, shake the jar or bottle to form an equilibrium suspension. The finished suspension contains 50 mg of amoxicillin per 1 ml. Before each use of the suspension, shake the bottle. Dosing of the suspension is carried out using a measuring spoon included in the kit.

The duration of use and dose of the drug Amosin is determined by the doctor.

• Adults and children weighing more than 40 kg (over 10 years old) are usually prescribed 500 mg of amoxicillin three times a day. In severe cases of the disease, the dose is increased to 750-1000 mg of amoxicillin three times a day.
• Children aged 5 to 10 years are usually prescribed 250 mg of amoxicillin three times a day.
• Children aged 2 to 5 years are usually prescribed 125 mg of amoxicillin three times a day.
• Children under 2 years of age are usually prescribed 20 mg of amoxicillin per 1 kg of body weight three times a day.
• The average duration of therapy is from 5 to 12 days (as a rule, the drug is continued for 2-3 days after the disappearance of clinical manifestations of the disease).

Specific treatment regimens with Amosin:

In the acute form of uncomplicated gonorrhea, adults are usually prescribed a single dose of 3000 mg of amoxicillin. Women may be prescribed to take the recommended dose of amoxicillin again.

1. For acute infectious diseases of the biliary tract and gastrointestinal tract, as well as gynecological diseases, adults are usually prescribed 1500-2000 mg of amoxicillin three times a day or 1000-1500 mg of amoxicillin four times a day.
2. For leptospirosis, adults are usually prescribed 500-750 mg of amoxicillin four times a day. The duration of taking Amosin is from 6 to 12 days.
3. In case of salmonella carriage, adults are usually prescribed 1500-2000 mg of amoxicillin three times a day. The duration of taking Amosin is 2-4 weeks.
4. To prevent endocarditis during minor surgical operations, adults are usually prescribed 3000-4000 mg of amoxicillin 60 minutes before surgery. If there is a high risk of developing endocarditis, amoxicillin is prescribed again 8-9 hours after taking the first dose. For children, it is recommended to reduce prophylactic doses of amoxicillin by half.

If renal function is impaired and creatinine clearance is from 15 to 40 ml/min, it is recommended to increase the interval between doses of amoxicillin to 12 hours (in this case, the single dose of Amosin is not changed).

If renal function is impaired and creatinine clearance is less than 10 ml/min, the dose of amoxicillin should be reduced by 15-50%.

With prolonged use of amoxicillin, it is recommended to monitor the function of the hematopoietic system, liver and kidneys.

Side effects

According to the instructions for Amosin, taking the drug can cause the following undesirable effects:

• From the urinary system – interstitial nephritis;
• From the central and peripheral nervous system - anxiety, agitation, ataxia, insomnia, behavior changes, confusion, peripheral neuropathy, convulsive reactions, dizziness, headache;
• From the digestive system - changes in taste, nausea, vomiting, dysbacteriosis, diarrhea, glossitis, stomatitis, liver dysfunction, pseudomembranous enterocolitis;
• Allergic reactions - skin hyperemia, urticaria, erythema, rhinitis, angioedema, conjunctivitis, joint pain, fever, exfoliative dermatitis, eosinophilia, Stevens-Johnson syndrome, exudative erythema multiforme, reactions similar to serum sickness, in isolated cases - anaphylactic shock;
• From the hematopoietic system – neutropenia, leukopenia, anemia, thrombocytopenic purpura.

In addition, the use of Amosin can cause tachycardia, superinfection, difficulty breathing and vaginal candidiasis.

Overdose

It is necessary to correctly understand why Amosin helps, and in what cases it causes harm. Of course, an overdose of the drug is unpleasant and dangerous to health. In case of taking increased doses of the drug, patients may develop vomiting, nausea, diarrhea, pain in the epigastric region, and possible disturbance of water and electrolyte balance.

In case of overdose, the patient should rinse the stomach and prescribe enterosorbent drugs. In case of overdose symptoms, symptomatic therapy should be prescribed. It would also be advisable to prescribe saline laxatives, as well as carry out procedures that maintain water and electrolyte balance.

special instructions

When using Amosin, it is necessary to monitor the state of the function of the kidneys, liver and hematopoietic organs.

1. During treatment with the drug, superinfection may develop, which requires a change in antibacterial therapy.
2. Patients with bacteremia may experience a Jarisch-Herxheimer reaction (bacteriolysis reaction), manifested by fever, chills, nausea, headache, tachycardia, decreased blood pressure and worsening symptoms of the underlying disease.
3. In case of hypersensitivity to penicillins, the use of Amosin may cause cross-allergic reactions with cephalosporin antibiotics.
4. When using amoxicillin and oral contraceptives containing estrogen simultaneously, it is recommended to use additional methods of protection against unwanted pregnancy.
5. If mild diarrhea occurs during treatment with Amosin, you should avoid prescribing drugs that reduce intestinal motility. To do this, you can use attapulgite or coalin-containing antidiarrheal agents. Severe diarrhea requires differential diagnosis and appropriate treatment.

Drug interactions

1. Medicines that block tubular secretion cause an increase in the concentration of amocillin, while the simultaneous use of Methotrexate increases the toxicity of the latter.
2. When amoxicillin is used simultaneously with glucosamines, aminoglycosides, laxatives and antacids, slow absorption is observed; when taken together with ascorbic acid, metabolism increases.
3. When used simultaneously with Metronidazole, nausea, vomiting, diarrhea, and pain in the epigastric region often develop.
4. In combination with clavulanic acid, the development of cholestatic jaundice, hepatitis, and erythema multiforme is possible.
5. Interaction with Probenecid increases the serum concentration of the antibiotic and reduces its excretion from the body. Amosin, like other antibacterial drugs, reduces the effectiveness of oral contraceptives.
6. Amosin's synergists are cephalosporins, aminoglycosides, rifampicin, vancomycin, cycloserine, antagonists are sulfonamides, macrolides, tetracyclines and lincosamides.

Simultaneous use with disulfiram is strictly contraindicated. Particular caution should be exercised when using amoxicillin and anticoagulants simultaneously (this may cause a prolongation of prothrombin time.

In this article you can read the instructions for use of the drug Amosin. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of the antibiotic Amosin in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Amosin in the presence of existing structural analogues. Use for the treatment of sore throat, pneumonia, sinusitis and other infectious diseases in adults, children, as well as during pregnancy and lactation. Composition and interaction of the drug with alcohol.

Amosin- a broad-spectrum antibiotic from the group of semisynthetic penicillins. Acts bactericidal. Inhibits transpeptidase, disrupts the synthesis of peptidoglycan (supporting polymer of the cell wall) during division and growth, and causes lysis of bacteria. Acid resistant.

Active against aerobic gram-positive bacteria: Staphylococcus spp. (staphylococcus) (except penicillinase-producing strains), Streptococcus spp. (streptococcus); aerobic gram-negative bacteria: Neisseria gonorrhoeae, Neisseria meningitidis, Bacillus anthracis, Listeria monocytogenes (Listeria), Helicobacter pylori (Helicobacter), Klebsiella spp. (klebsiella).

Microorganisms that produce penicillinase are resistant to amoxicillin.

The action develops 15-30 minutes after administration and lasts 8 hours.

Compound

Amoxicillin (in trihydrate form) + excipients.

Pharmacokinetics

After oral administration, Amosin is quickly and almost completely (93%) absorbed from the gastrointestinal tract. Eating does not affect the absorption of the drug and is not destroyed in the acidic environment of the stomach. Found in high concentrations in plasma, sputum, bronchial secretions (distribution in purulent bronchial secretions is poor), pleural and peritoneal fluid, urine, contents of skin blisters, lung tissue, intestinal mucosa, female genital organs, prostate gland, middle ear fluid, bone , adipose tissue, gall bladder (with normal liver function), fetal tissue. When the dose is doubled, the concentration also doubles. The concentration in bile exceeds the concentration in plasma by 2-4 times. In the amniotic fluid and umbilical cord vessels, the concentration of amoxicillin is 25-30% of the plasma level in a pregnant woman. It penetrates the blood-brain barrier (BBB) ​​poorly; in case of inflammation of the meninges (meningitis), the concentration in the cerebrospinal fluid is about 20%. Plasma protein binding - 17%. A small amount is excreted in breast milk. Amoxicillin is partially metabolized to form inactive metabolites. Amoxicillin is excreted 50-70% unchanged in the urine by tubular excretion (80%) and glomerular filtration (20%), with bile - 10-20%.

Indications

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

• respiratory infections (including bronchitis, pneumonia);
• infections of the ENT organs (including sinusitis, pharyngitis, tonsillitis, acute otitis media);
• infections of the genitourinary system (including pyelonephritis, pyelitis, cystitis, urethritis, gonorrhea);
• gynecological infections (including endometritis, cervicitis);
• infections of the gastrointestinal tract (including peritonitis, enterocolitis, typhoid fever, cholangitis, cholecystitis);
• infections of the skin and soft tissues (including erysipelas, impetigo, secondary infected dermatoses);
• leptospirosis;
• listeriosis;
• Lyme disease (borreliosis);
• dysentery;
• salmonellosis, salmonella carriage;
• meningitis;
• endocarditis (prevention);
• sepsis.

Release forms

Capsules 250 mg.

Tablets 250 mg and 500 mg.

Powder for the preparation of suspension for oral administration 125 mg, 250 mg and 500 mg.

Instructions for use and dosage

The drug is taken orally, before or after meals. The dosage regimen is set individually, taking into account the severity of the disease, the sensitivity of the pathogen to the drug, and the age of the patient.

Adults and children over 10 years old (with a body weight of more than 40 kg) are prescribed 500 mg 3 times a day, in case of severe disease - 0.75-1 g 3 times a day.

Children aged 5 to 10 years are prescribed 250 mg 3 times a day, from 2 to 5 years old - 125 mg 3 times a day, for children under 2 years old - 20 mg/kg per day in 3 divided doses. The course of treatment is 5-12 days.

For children under 5 years of age, the drug is prescribed in the form of a suspension (the ideal pediatric form of the drug).

For the treatment of acute uncomplicated gonorrhea, the drug is prescribed in a dose of 3 g once; When treating women, repeated administration of the indicated dose is recommended.

For acute infectious diseases of the gastrointestinal tract (paratyphoid fever, typhoid fever) and biliary tract, for gynecological infectious diseases, adults are prescribed 1.5-2 g 3 times a day or 1-1.5 g 4 times a day.

For leptospirosis, adults are prescribed 500-750 mg 4 times a day for 6-12 days.

For salmonella-carrying adults - 1.5-2 g 3 times a day for 2-4 weeks.

To prevent endocarditis during minor surgical interventions, adults are prescribed a dose of 3-4 g 1 hour before the procedure. If necessary, a repeat dose is prescribed after 8-9 hours. In children, the dose is halved.

Rules for preparing a suspension from a single-dose package

Boiled and cooled water is poured into a clean glass in the amount indicated in the table, then the contents of one package are poured out and mixed until a homogeneous suspension is obtained.

• The dose in the package is 125 mg - the required amount of water is 2.5 ml;
• dose in a package 250 mg - required amount of water 5 ml;
• dose in a package 500 mg - required amount of water 10 ml.

After use, rinse the glass with water, dry and store in a dry, clean place.

Side effect

• hives;
• skin hyperemia;
• erythema;
• angioedema;
• rhinitis;
• conjunctivitis;
• fever;
• joint pain;
• eosinophilia;
• exfoliative dermatitis;
• exudative erythema multiforme;
• Stevens-Johnson syndrome;
• reactions similar to serum sickness;
• anaphylactic shock;
• dysbacteriosis;
• change in taste;
• vomiting, nausea;
• diarrhea;
• stomatitis;
• glossitis;
• pseudomembranous enterocolitis;
• excitation;
• anxiety;
• insomnia;
• confusion;
• behavior change;
• depression;
• peripheral neuropathy;
• headache;
• dizziness;
• convulsive reactions;
• interstitial nephritis;
• leukopenia, neutropenia, thrombocytopenic purpura, anemia;
• labored breathing;
• tachycardia;
• vaginal candidiasis;
• superinfection (especially in patients with chronic diseases or reduced body resistance).

Contraindications

• allergic diathesis;
• bronchial asthma, hay fever;
• Infectious mononucleosis;
• lymphocytic leukemia;
• liver failure;
• history of gastrointestinal diseases (especially colitis associated with the use of antibiotics);
• lactation period (breastfeeding);
• hypersensitivity to the components of the drug;
• hypersensitivity to other penicillins, cephalosporins, carbapenems;
• children under 3 years of age (for tablets and capsules).

Use during pregnancy and breastfeeding

The use of the drug during pregnancy is possible only in cases where the expected benefit of therapy for the mother outweighs the potential risk to the fetus.

Use during lactation is contraindicated. If use is necessary during lactation, breastfeeding should be stopped.

Use in children

Contraindicated in children under 3 years of age (for tablets and capsules). For children under 5 years of age, the drug is prescribed in the form of a suspension.

special instructions

When carrying out a course of treatment with Amosin, it is necessary to monitor the state of the function of the hematopoietic organs, liver and kidneys.

Superinfection may develop due to the growth of microflora insensitive to amoxicillin, which requires a corresponding change in antibacterial therapy.

When treating patients with bacteremia, a bacteriolysis reaction (Jarisch-Herxheimer reaction) rarely develops.

In patients who are hypersensitive to penicillins, cross-allergic reactions with cephalosporin antibiotics are possible.

When treating mild diarrhea while using Amosin, you should avoid prescribing antidiarrheal drugs that reduce intestinal motility; You can use kaolin- or attapulgite-containing antidiarrheal agents. In case of severe diarrhea, it is necessary to carry out differential diagnosis and prescribe appropriate therapy.

Treatment should be continued for another 48-72 hours after the disappearance of clinical signs of the disease.

When using estrogen-containing oral contraceptives and amoxicillin simultaneously, additional methods of contraception should be used, if possible.

Drug interactions

Antacids, glucosamine, laxatives, food, antibiotics of the aminoglycoside group, when used simultaneously, slow down and reduce the absorption of Amosin; ascorbic acid - increases its absorption.

Bactericidal antibiotics (including aminoglycosides, cephalosporins, cycloserine, vancomycin, rifampicin) exhibit synergism with amoxicillin; bacteriostatic drugs (macrolides, chloramphenicol, lincosamines, tetracyclines, sulfonamides) - antagonism.

Amoxicillin, when used simultaneously, increases the effectiveness of indirect anticoagulants (by suppressing intestinal microflora, reducing the synthesis of vitamin K and the prothrombin index); reduces the effectiveness of estrogen-containing oral contraceptives, ethinyl estradiol (the risk of intermenstrual bleeding), as well as drugs, during the metabolism of which para-aminobenzoic acid is formed.

The combined use of Amosin with alcohol is prohibited (the hepatotoxic effect of ethanol is enhanced).

Diuretics, allopurinol, oxyphenbutazone, phenylbutazone, nonsteroidal anti-inflammatory drugs (NSAIDs) and drugs that block tubular secretion, when used simultaneously with Amosin, reduce tubular secretion and increase the concentration of amoxicillin.

When Amosin is used simultaneously with allopurinol, the risk of developing a skin rash increases.

Amoxicillin, when used simultaneously, reduces the clearance and increases the toxicity of methotrexate.

Amoxicillin, when used simultaneously, enhances the absorption of digoxin.

Analogues of the drug Amosin

Structural analogues of the active substance:

• Amoxisar;
• Amoxicillin;
• Amoxicillin trihydrate;
• Gonoform;
• Grunamox;
• Danemox;
• Ospamox;
• Flemoxin Solutab;
• Hiconcil;
• Ecobol.

If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.