Ascoril instructions for use syrup. Ascoril: syrup. Instruction for children and adults. From what cough and how to take. Price. Analogues. Special instructions and precautions

Ascoril syrup is a combined drug with expectorant, bronchodilator, mucolytic action.

Active ingredients: bromhexine, guaifenesin and salbutamol.

- a bronchodilator, stimulates β2-adrenergic receptors of the bronchi, blood vessels and myometrium. Prevents or eliminates bronchospasm, reduces resistance in the airways, increases the vital capacity of the lungs. Causes expansion of the coronary arteries, does not lower blood pressure.

- mucolytic agent, has an expectorant and antitussive effect. Increases the serous component of bronchial secretion; activates the cilia of the ciliated epithelium, reduces the viscosity of sputum, increases its volume and improves discharge.

Guaifenesin is a mucolytic agent that reduces the surface tension of the structures of the bronchopulmonary apparatus; stimulates the secretory cells of the bronchial mucosa that produce neutral polysaccharides, depolymerizes acid mucopolysaccharides, reduces the viscosity of sputum, activates the ciliary apparatus of the bronchi, facilitates the removal of sputum and promotes the transition of an unproductive cough into a productive one.

Ascoril is produced in the form of syrup and tablets.

Indications for use

What helps Ascoril Expectorant? According to the instructions, the syrup is prescribed as part of a combination therapy for acute and chronic bronchopulmonary diseases, accompanied by the formation of a difficult-to-separate viscous secret:

• bronchial asthma;
• tracheobronchitis;
• obstructive bronchitis;
• pneumonia;
• emphysema;
• whooping cough;
• pneumoconiosis;
• pulmonary tuberculosis.

Instructions for use Ascoril, syrup dosages

The syrup is taken orally after a meal, it is permissible to drink liquid. Shake before use.

Standard dosages of Ascoril syrup for children and adults, according to the instructions for use:

• adults and children over 12 years old - 10 ml (2 teaspoons);
• from 6 to 12 years - 5-10 ml (1-2 teaspoons);
• children under 6 years old - 5 ml (1 teaspoon).

If necessary, the doctor can increase the dosage of the drug, you should not do this yourself.

Ascoril syrup is not prescribed simultaneously with preparations containing codeine and other antitussives, as this makes it difficult to expel liquefied sputum.

Side effects

The instruction warns of the possibility of developing the following side effects when prescribing Ascoril syrup:

• Allergic reactions: rash, urticaria, bronchospasm.
• From the nervous system: headache, dizziness, increased nervous excitability, sleep disturbance, drowsiness, tremor, convulsions.
• On the part of the digestive system: nausea, vomiting, diarrhea, exacerbation of peptic ulcer of the stomach and duodenum, increased activity of "liver" transaminases.
• From the CCC: tachycardia, lowering blood pressure, collapse.
• From the urinary system: pink coloration of urine (due to the content of guaifenesin).

The risk of developing undesirable effects increases when the drug is combined with theophylline, other beta2-adrenomimetic agents, since they increase the activity of salbutamol.

Contraindications

It is contraindicated to prescribe Ascoril Expektorant in the following cases:

• hypersensitivity to the components of the drug;
• pregnancy and lactation;
• tachyarrhythmia;
• myocarditis;
• heart defects;
• decompensated diabetes mellitus;
• thyrotoxicosis;
• glaucoma;
• liver or kidney failure;
• peptic ulcer of the stomach and duodenum in the acute stage;
• stomach bleeding;
• arterial hypertension.

Be wary appoint patients with diabetes mellitus, gastric ulcer and duodenal ulcer in remission.

Store in a place protected from moisture and light at temperatures up to 25 ° C. Keep away from children. Shelf life - 2 years.

Conditions for dispensing from pharmacies - by prescription.

Instruction

on the medical use of a medicinal product

Ascoril Investigator

Tradename

Ascoril Investigator

International non-proprietary name

Dosage form

Syrup, 100 and 200 ml

Compound

10 ml syrup contains

active substances: salbutamol sulfate

(equivalent to salbutamol) - 2.00 mg

bromhexine hydrochloride - 4.00 mg

guaifenesin - 100.00 mg

menthol (levomenthol) - 1.00 mg,

Excipients: sodium benzoate, citric acid monohydrate, sorbitol, glycerin, propylene glycol, Sunset Yellow FCF, pineapple flavor, blackcurrant flavor ID20158, sorbic acid, sucrose, purified water.

Description

A thick, transparent, orange-colored viscous liquid with a sweet taste.

Farmacotherapeutic group

Sympathomimetics for systemic use. Sympathomimetics in combination with other drugs for the treatment of obstructive airways disease.

ATX code R03SK

Pharmacological properties

Pharmacokinetics

Salbutamol is well absorbed in the gastrointestinal tract with a bioavailability of 50% - 85%. Peak plasma concentrations (C max) occur 1 to 4 hours (T max) after oral administration of salbutamol. Eating does not affect the bioavailability of salbutamol. Plasma protein binding is 10% and the volume of distribution (Vd) is 156 +/- 38 liters. Salbutamol is metabolized in the liver to its active metabolite, 4-O-sulfate ester. Salbutamol is excreted with urine - 64% and with bile. The half-life of salbutamol is 3-6.5 hours.

Bromhexine is well absorbed from the gastrointestinal tract. The maximum plasma concentration (C max) is observed 1 hour after oral administration. Bromhexine is metabolized in the liver to the active metabolite ambroxol. Bromhexine is excreted mainly in the urine in the form of metabolites. Only a small amount is excreted unchanged. The half-life of T ½ of bromhexine is 6.5 hours.

Guaifenesin is well absorbed from the gastrointestinal tract. 60% of guaifenesin is hydrolyzed in the blood within 7 hours with the formation of ß-2-methoxyphenoxy-lactic acid. An overdose of guaifenesin can cause urolithiasis; stones contain a guaifenesin metabolite: ß-2 - methoxyphenol-lactic acid. Guaifenesin is excreted in the urine as metabolites. The half-life T ½ is 1 hour.

After absorption, menthol is excreted in the urine and bile as a glucuronide.

Pharmacodynamics

Ascoril expectorant is a combined preparation with bronchodilating, mucolytic and expectorant action. Due to the rational combination of salbutamol, bromhexine hydrochloride, guaifenesin and menthol, the severity of functional disorders of the respiratory system is effectively and quickly reduced.

Salbutamol is a selective agonist of β 2 -adrenergic receptors, has a bronchodilator effect, relieves bronchospasm.

Bromhexine hydrochloride has a mucolytic effect. Reduces the viscosity of bronchial secretions by depolarizing acidic polysaccharides and stimulating the secretory cells of the bronchial mucosa.
Guaifenesin reduces the surface tension and adhesive properties of sputum, promotes expectoration.
Menthol has an antispasmodic effect, gently stimulates the secretion of bronchial glands, has antiseptic properties, has a calming effect and reduces irritation of the respiratory mucosa.

Indications for use

acute and chronic bronchopulmonary diseases (bronchial asthma,

tracheobronchitis, obstructive bronchitis, pneumonia, emphysema,

whooping cough, pneumoconiosis and others), accompanied by the formation of difficult

detachable viscous secretion (as part of combination therapy)

Cough with acute respiratory infections

Dosage and administration

inside. Adults: 10 ml (2 teaspoons) of syrup 3 times a day.

The duration of treatment is determined individually.

Side effects

With long-term use

Nausea, vomiting, dyspepsia, diarrhea, exacerbation of peptic ulcer of the stomach and duodenum

Rarely

Transient expansion of peripheral vessels, decrease in blood pressure, collapse, headache, dizziness, mild tachycardia

Increased nervous excitability

Tremors, muscle cramps, sleep disturbance

Allergic reactions, incl. angioedema, skin rash, urticaria, paradoxical bronchospasm

hypokalemia

Pink discoloration of urine

Very rarely

Increased activity of transaminases

Contraindications

Hypersensitivity to the active and excipients of the drug

Simultaneous use of antitussives, non-selective beta-adrenergic blockers, MAO inhibitors

Tachycardia, myocarditis, heart disease

Diabetes

Peptic ulcer of the stomach, duodenum (in the stage of exacerbation)

stomach bleeding

hyperthyroidism

Glaucoma

Pregnancy, lactation

Children and adolescents up to 18 years of age

Drug Interactions

Other beta 2-agonists and theophylline increase the effect of salbutamol and increase the likelihood of side effects.
Ascoril expectorant is not prescribed simultaneously with drugs,

containing codeine and other antitussives, tk. this makes it difficult to expel liquefied sputum.
It is not recommended to use the drug simultaneously with such non-selective beta-adrenergic blockers as propranolol. Salbutamol, which is part of the drug Ascoril Expectorant, is not recommended for patients who receive monoamine oxidase inhibitors.
Diuretics and glucocorticosteroid preparations enhance the hypokalemic effect of salbutamol.

special instructions

Bromhexine, which is part of the drug, promotes the penetration of antibiotics (erythromycin, cephalexin, oxytetracycline) into the lung tissue.

Diuretics and glucocorticosteroids enhance the hypokalemic effect of salbutamol. Simultaneous administration with preparations containing codeine and other antitussives makes it difficult to expel liquefied sputum.

Guaifenesin turns urine pink.

Features of the influence of the drug on the ability to drive a vehicle or potentially dangerous mechanisms

Given that sensitive patients may experience tachycardia, hand tremors, muscle cramps while taking the drug, it is better to refrain from driving vehicles and mechanisms, performing work that requires concentration.

Overdose

Symptoms- possible increase in side effects.
Treatment- symptomatic.

Release form and packaging

100 ml or 200 ml syrup in a polyethylene bottle with a 10 ml measuring cap.

1 bottle along with instructions for medical use on

state and Russian languages ​​put in a pack of cardboard.

Storage conditions

Store in a dry, dark place at a temperature not exceeding 25ºС.

Keep out of the reach of children!

Shelf life

Do not use after the expiration date.

Terms of dispensing from pharmacies

On prescription

Manufacturer

Glenmark Pharmaceuticals Ltd, PLOT No. E 37.39, MIDS Area, Saptur, Nasik - 422007, Maharashtra, India.

Registration certificate holder

Glenmark Pharmaceuticals Ltd, India

A address of the organization accepting claims on product quality from consumers in the territory of the Republic of Kazakhstan

Representative office of Glenmark Pharmaceuticals LTD in the Republic of Kazakhstan, 050005, Almaty, Al-Farabi Avenue, 7, business center "Nurly Tau", block 4 A, office 7.

The well-being of the whole organism depends on the health of the respiratory tract, so respiratory diseases should not be left to chance. Both adults and children can face bronchitis, pneumonia, bronchial asthma and other pathologies. Therapy of respiratory diseases is not complete without cough syrups / tablets. After reviewing the prescription prescribed by the doctor, some may be interested in the instructions for using Ascoril syrup.

Composition and pharmacological properties

Ascoril syrup is a drug that has a combined composition that improves sputum discharge. It is included in the Register of Medicinal Products of Russia (RLS).

10 ml of syrup (solution is orange, viscous and has a specific aroma) contains 3 main active ingredients:

• salbutamol (in the form of sulfate) - 2 mg;
• bromhexine hydrochloride - 4 mg;
• guaifenesin - 100 mg.

In addition, the composition contains additional auxiliary substances, including flavors, dyes and preservatives.

Ascoril cough syrup is endowed with bronchodilator (expands the bronchi by relaxing their smooth muscles), expectorant (provides the removal of bronchial secretions from the respiratory tract) and mucolytic (thinns sputum and facilitates its removal from the respiratory tract) action.

The following components are responsible for such pharmacotherapeutic effects:

1. Salbutamol is a beta-agonist with a pronounced bronchodilator effect. It is able to prevent or eliminate a sharp narrowing of the bronchial lumen, reduces inelastic resistance in the airways ways. When administered orally, salbutamol is rapidly absorbed and half of the administered dose is in the systemic circulation. Eating somewhat slows down the absorption of salbutamol.
2. Bromhexine is a mucolytic with pronounced expectorant properties. This component effectively reduces the viscosity of bronchial secretions. Bromhexine is rapidly absorbed in the gastrointestinal tract and primarily passes through the hepatobiliary region, where it is extensively metabolized. The peak concentration of bromhexine in blood plasma occurs 1 hour after taking the syrup. The active substance is widely distributed in the tissues of the patient's body.
3. Guaifenesin is an expectorant that reduces the surface tension between the structural units of the bronchi and lungs. Reduces the viscosity of sputum and facilitates its discharge from the respiratory tract. Quickly, within half an hour, it is absorbed from the digestive tract after oral consumption. The active substance remains effective for an hour.

Salbutamol and bromhexine are excreted from the body mainly by the kidneys. Guaifenesen also partially leaves the patient's body through the kidneys, and is also excreted by the lungs with sputum. Bromhexine, unlike other components, can accumulate with repeated use.

What kind of cough to take Ascoril

Cough that occurs in children and adults is usually divided into the following types:

1. Dry, which is also called unproductive. Most often, it accompanies acute respiratory diseases, as well as inflammation of the larynx, mucous membrane and lymphoid tissue of the pharynx, the initial stage of the inflammatory process in the bronchi and trachea. In all these cases, sputum is usually absent.
2. Wet, the second name is productive. It most often becomes a sure sign of an acute infectious process in the lungs with the involvement of all components of the lung tissue or inflammation of the mucous membrane of the bronchial tree. For a productive cough, the presence of sputum is characteristic, but in some cases its discharge is difficult.
3. Acute cough. It usually lasts no more than 20 days. It can be provoked by infectious diseases caused by bacteria and viruses, as well as various allergens that enter the mucous membrane of the larynx.
4. Chronic cough. If such a symptom is present for more than 3 weeks, then they speak of a protracted pathological condition. But it can be caused not only by diseases of the upper and lower respiratory tract, but also by diseases of the stomach and heart. In addition, the chronic cough of smokers, allergy sufferers and patients observed by neurologists is separately isolated.
5. Periodic cough. Such a symptom can from time to time accompany various diseases. It can intensify at a certain time of the day (at night or in the morning), or it can appear at any time of the day or night spontaneously. As a rule, it is short-lived, flowing in attacks.
6. Persistent cough. A painful condition in which a person coughs without stopping with a slight weakening, but without complete disappearance. Such a symptom greatly affects the quality of life of the patient, does not allow a person to fully rest, eat. In this condition, the patient should not hesitate to seek medical help.

Ascoril is suitable in almost all cases, but it is especially good for wet coughs.. However, it is not always used as a monopreparation. Usually they resort to complex therapy, which includes antibiotics, antiviral, antihistamines and other drugs.

According to the official instructions, Ascoril helps against such acute and chronic diseases of the lungs and bronchi:

• bronchial asthma is a chronic inflammatory disease of the respiratory organs, the main symptoms of which are attacks of shortness of breath, coughing, and sometimes suffocation;
• tracheobronchitis - an acute respiratory disease that occurs with an inflammatory lesion of the mucous membrane of the trachea and bronchi;
• obstructive bronchitis - an inflammatory process in the branches of the windpipe, in which the patency of the airways is impaired;
• pneumonia is an acute inflammatory disease of the lungs, which most often has a viral nature and captures all the constituent elements of lung tissues, mainly the respiratory section (alveoli);
• pulmonary emphysema is a disease of the respiratory tract, in which there is a pathological expansion of the air spaces of the terminal branches of the bronchial tree;
• whooping cough is an acute bacterial infection in which a spasmodic cough appears in the form of bouts;
• pneumoconiosis - an occupational lung disease resulting from prolonged inhalation of dust of various compositions;
• Pulmonary tuberculosis is a local manifestation of a general infectious disease resulting from infection with Mycobacterium tuberculosis.

In some pathological processes, you may need drugs that stop coughing by influencing the corresponding center of the brain, but they should be taken only as prescribed by the attending physician.

Dosing regimen

Ascoril syrup is available in a standard dosage. It is not divided into Ascoril for children and for adults. The only difference is the amount of medication taken. Unless the doctor prescribes otherwise, the drug is usually taken as follows:

• Ascoril syrup for adults and children from 12 years old is given 2 teaspoons 3 times a day;
• the use of syrup for children from 6 to 12 years old implies 1-2 teaspoons in 3 doses;
• children under the age of 6 Ascoril are allowed to use 1 teaspoon 3 times a day.

Children under one year of age are allowed to take the drug only after consulting a pediatrician and strictly according to the scheme that he recommends.

The duration of admission depends on the complexity of the clinical case and the body's response to the treatment. Children Ascoril can drink up to 5 days. Ascoril cough syrup can be taken both before and after meals. However, it should be borne in mind that this is a syrup with salbutamol, so that food does not reduce its absorption rate, it is better to take Ascoril 1 hour after eating.

Side effects

Ascoril for bronchitis and other diseases of the upper and lower respiratory tract is very effective, acts quickly and is well tolerated by patients. However, when using the drug in high doses, side effects are not excluded:

• headache attacks;
• a feeling of a violation of the orientation of the body in space;
• increased emotional excitability (touchiness, tearfulness, aggressiveness);
• sleep problems (insomnia, drowsiness);
• fast, rhythmic movements of the limbs or torso, caused by muscle contractions, as well as involuntary contraction of a muscle or group of muscles, usually accompanied by sharp and aching pain;
• disorders in the digestive tract (intestinal upset, vomiting, painful sensation in the epigastric region);
• exacerbation of ulcerative defects on the mucous membrane of the stomach and duodenum;
• change in heart rate (tachycardia);
• possible staining of urine in pink color;
• sudden cardiovascular failure, with loss of consciousness and the threat of death;
• a sudden change in the lumen between the small bronchi and bronchioles as a result of contraction of the muscles of the bronchial wall;
• skin allergic manifestations in the form of a severely itchy rash.

The above adverse reactions of the body are aggravated with an intentional or accidental overdose. In this case, you should stop taking the drug and carry out symptomatic treatment. There is no special antidote for an overdose of Ascoril.

Contraindications

Ascoril in the form of syrup is contraindicated for oral use in such clinical cases:

• individual intolerance of patients to one of the main or auxiliary components of the drug;
• inflammatory damage to the myocardium, a pathological disturbance of the heart rhythm, in which, against the background of a significant increase in the frequency of heart contractions, there is a violation of their periodicity;
• congenital or acquired changes in the structures of the heart;
• a condition in which the blood sugar level is not corrected or its correction with medicines is insufficient;
• a condition caused by a persistent increase in the level of thyroid hormones (thyroid hormone intoxication);
• eye diseases, which are characterized by a constant or periodic increase in intraocular pressure;
• insufficient functioning of the hepatobiliary or urinary system;
• period of exacerbation of peptic ulcer of the stomach and duodenum;
• bleeding in the lumen of the gastrointestinal tract.

Ascoril with a dry cough in a child is contraindicated when used simultaneously with antitussive drugs (Sinekod, Libeksin, Bronholitin).

Pregnant Ascoril is contraindicated at any time, but especially in the first trimester. If there is a need to take syrup during lactation, then a temporary transition to artificial feeding may be considered.

Interactions with drugs and alcohol

During treatment with Ascoril, the following points should be considered:

1. The components that make up this cough syrup enhance the effect of ethanol, so the simultaneous intake of Ascoril and alcohol is unacceptable.
2. Fenoterol, Terbutanil, Theophylline increase the effect of salbutamol, so the likelihood of adverse reactions increases.
3. The combination of codeine and other drugs that suppress the cough center in the central nervous system is not acceptable, since liquefied sputum will not be able to fully leave the respiratory tract.
4. Taking Ascoril against the background of antibiotic therapy promotes the penetration of first-generation cephalosporins, erythromycin and other macrolides into lung tissue due to the presence of bromhexine in the composition.
5. Caution should be exercised when taking Ascoril together with Anaprilin and its analogues.
6. In view of the salbutamol contained in Ascoril, it is not recommended to take patients taking antidepressants (MAO inhibitors).
7. Salbutamol reduces the concentration of potassium in the blood, and if you take Ascoril together with diuretics and steroid drugs, then this effect only increases.

Against the background of treatment with Ascoril, it is not appropriate to use alkaline drinks (mineral waters, milk with soda).

conclusions

Ascoril is an effective drug that is indispensable for a wet cough with difficult sputum discharge. But its price may turn some patients off. Sometimes pharmacies offer Cashnol as an alternative. Or if you immediately warn your doctor about the constrained financial opportunities, then perhaps he will prescribe Bromhexine, Salbutamol and Guaifenesin syrup separately, or maybe only one thing, based on the testimony.

However, combined preparations best promote coughing and help solve the problem in a matter of days, so in some cases it is advisable to buy Ascoril if it is prescribed by the attending physician. With strict adherence to the instructions for use, the patient will be able to quickly notice the positive dynamics.

In this article, you can read the instructions for using the drug Ascoril. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Ascoril in their practice are presented. We kindly ask you to actively add your reviews about the drug: the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Analogues of Ascoril in the presence of existing structural analogues. Use for the treatment of cough as a symptom of bronchitis, pneumonia in adults, children, as well as during pregnancy and lactation. The composition of the drug.

Ascoril- a combined drug that has a bronchodilator, expectorant and mucolytic effect.

Salbutamol is a bronchodilator that stimulates beta2-adrenergic receptors of the bronchi, blood vessels and myometrium. Prevents or eliminates bronchospasm, reduces resistance in the airways, increases the vital capacity of the lungs. Causes expansion of the coronary arteries, does not lower blood pressure.

Bromhexine is a mucolytic agent that has an expectorant and antitussive effect. Increases the serous component of bronchial secretion; activates the cilia of the ciliated epithelium, reduces the viscosity of sputum, increases its volume and improves discharge.

Guaifenesin is a mucolytic agent that reduces the surface tension of the structures of the bronchopulmonary apparatus; stimulates the secretory cells of the bronchial mucosa that produce neutral polysaccharides, depolymerizes acid mucopolysaccharides, reduces the viscosity of sputum, activates the ciliary apparatus of the bronchi, facilitates the removal of sputum and promotes the transition of an unproductive cough into a productive one.

The composition of the drug

Salbutamol (as sulfate) + Bromhexine hydrochloride + Guaifenesin + excipients.

Pharmacokinetics

Salbutamol

When taken orally, absorption is high. Food intake reduces the rate of absorption, but does not affect bioavailability. Penetrates through the placenta. It is excreted by the kidneys (69-90%), mainly in the form of an inactive phenol sulfate metabolite (60%) within 72 hours and with bile (4%).

Bromhexine

When taken orally, it is almost completely (99%) absorbed from the gastrointestinal tract within 30 minutes. Bioavailability - low (the effect of the primary "passage" through the liver). Penetrates through the placental barrier and the blood-brain barrier. Excreted by the kidneys. In chronic renal failure, excretion of metabolites is impaired. With repeated use, it can accumulate.

Guaifenesin

Absorption from the gastrointestinal tract is fast (25-30 minutes after ingestion). T1 / 2 - 1 hour Penetrates into tissues containing acid mucopolysaccharides. Approximately 60% of the administered drug is metabolized in the liver. It is excreted by the lungs (with sputum) and by the kidneys both unchanged and in the form of inactive metabolites.

Indications

As part of the combined therapy of acute and chronic broncho-pulmonary diseases, accompanied by the formation of a difficult-to-separate viscous secret:

• bronchial asthma;
• tracheobronchitis;
• obstructive bronchitis;
• pneumonia;
• emphysema;
• whooping cough;
• pneumoconiosis;
• pulmonary tuberculosis.

Release form

Pills.

Syrup Ascoril expectorant (children's form of the drug).

Instructions for use and dosing regimen

Pills

inside. Adults and children over 12 years of age are prescribed 1 tablet 3 times a day.

Children aged 6 to 12 years - 0.5 or 1 tablet 3 times a day.

Syrup

Adults and children over 12 years of age are prescribed 10 ml (2 teaspoons) 3 times a day.

Children under 6 years old - 5 ml (1 teaspoon) 3 times a day, from 6 to 12 years old - 5-10 ml (1-2 teaspoons) 3 times a day.

Side effect

• headache;
• dizziness;
• increased nervous excitability;
• sleep disturbance;
• drowsiness;
• tremor;
• convulsions;
• nausea, vomiting;
• diarrhea;
• exacerbation of peptic ulcer of the stomach and duodenum;
• cardiopalmus;
• possible staining of urine in pink color;
• allergic reactions (rash, urticaria);
• collapse;
• bronchospasm.

Contraindications

• hypersensitivity to the components of the drug;
• pregnancy;
• lactation period;
• tachyarrhythmia;
• myocarditis;
• heart defects;
• decompensated diabetes mellitus;
• thyrotoxicosis;
• glaucoma;
• liver or kidney failure;
• peptic ulcer of the stomach and duodenum in the acute stage;
• stomach bleeding;
• arterial hypertension;
• children's age up to 6 years.

Use during pregnancy and lactation

During pregnancy, the drug is not recommended.

If necessary, treatment with the drug during lactation, breastfeeding should be discontinued.

special instructions

Ascoril expectorant is prescribed with caution in patients with hyperthyroidism, diabetes mellitus, severe diseases of the cardiovascular system, arterial hypertension, gastric ulcer and duodenal ulcer.

Ascoril expectorant should not be used in combination with beta-blockers.

drug interaction

Other beta2-agonists and theophylline increase the effect of salbutamol and increase the likelihood of side effects.

Ascoril is not prescribed simultaneously with preparations containing codeine and other antitussives, as this makes it difficult to expel liquefied sputum.

Bromhexine, which is part of the Ascoril preparation, promotes the penetration of antibiotics (erythromycin, cephalexin, oxytetracycline) into the lung tissue.

Ascoril salbutamol, which is part of the drug, is not recommended for patients who receive MAO inhibitors.

Diuretics and glucocorticosteroids enhance the hypokalemic effect of salbutamol.

Ascoril's analogs

Ascoril has no structural analogues for the active substance.

Analogues for the therapeutic effect (secretolitics):

• Ambroxol;
• Amtersol;
• Bromhexine;
• Bronchicum;
• Bronchipret;
• Breast collection No. 1;
• Breast collection No. 2;
• Breast collection No. 3;
• Breast elixir;
• Dr. MOM herbal cough lozenges;
• Insty;
• Cashnol;
• Codelac Broncho with thyme;
• Coldact Broncho;
• Lazolvan;
• Linkas Balm;
• Dry cough syrup for adults;
• Dry cough syrup for children;
• Ammonia-anise drops;
• expectorant collection;
• Pectusin;
• Pertussin;
• Rinicold Broncho;
• Stoptussin;
• Sudafed;
• Tussin plus;
• Eucathol.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.

Ascoril- a combined drug with bronchodilator and expectorant action. It is used to treat acute and chronic broncho-pulmonary diseases, accompanied by the formation of a difficult-to-separate viscous secretion and bronchospastic syndrome (bronchial asthma, bronchitis, tracheobronchitis, bronchiectasis, emphysema, pneumonia, whooping cough, etc.).

Ascoril cough syrup is a combination drug that includes salbutamol, guaifenesin and bromhexine. The composition is selected in such a way that all components of the drug complement each other's medicinal effect, enhancing it.

Ascoril: Instructions for use

Composition and form of release

Tablets Ascoril

1 Ascoril tablet contains:

10 pcs. packaged.

Syrup Ascoril expectant

10 ml syrup Ascoril expectorant contains:

100 ml in vials.

Active substances

pharmachologic effect

The combined drug has a bronchodilator, expectorant and mucolytic effect. Salbutamol is a bronchodilator that stimulates beta2-adrenergic receptors of the bronchi, blood vessels and myometrium. Prevents or eliminates bronchospasm, reduces resistance in the airways, increases VC. Causes expansion of the coronary arteries, does not reduce blood pressure. Bromhexine is a mucolytic agent that has an expectorant and antitussive effect. Increases the serous component of bronchial secretion; activates the cilia of the ciliated epithelium, reduces the viscosity of sputum, increases its volume and improves discharge. Guaifenesin is a mucolytic agent that reduces the surface tension of the structures of the bronchopulmonary apparatus; stimulates the secretory cells of the bronchial mucosa that produce neutral polysaccharides, depolymerizes acid mucopolysaccharides, reduces the viscosity of sputum, activates the ciliary apparatus of the bronchi, facilitates the removal of sputum and promotes the transition of an unproductive cough into a productive one.

Indications for use

Acute and chronic broncho-pulmonary diseases, accompanied by the formation of a difficult-to-separate viscous secret:

• bronchial asthma;
• tracheobronchitis;
• obstructive bronchitis;
• pneumonia;
• emphysema;
• whooping cough;
• pneumoconiosis;
• pulmonary tuberculosis.

and others (as part of combination therapy).

Be wary appoint patients with diabetes mellitus, gastric ulcer and duodenal ulcer in remission.

Dosage and administration

Syrup Ascoril expectant

Inside, adults and children over 12 years of age are prescribed 10 ml (2 teaspoons) 3 times / day.

Children under 6 years old - 5 ml (1 teaspoon) 3 times / day, from 6 to 12 years old - 5-10 ml (1-2 teaspoons) 3 times / day. If necessary, it is possible to increase the dose.

Tablets Ascoril

inside. Adults and children over 12 years old - 1 tablet 3 times a day; children from 6 to 12 years old - 1/2 or 1 tablet 3 times a day.

Overdose

Symptoms: may increase the manifestations of side effects.
Treatment: if necessary, carry out symptomatic therapy.

Contraindications

1. individual intolerance (including history of hypersensitivity) components of Ascoril;
2. tachycardia, heart rhythm disturbances, tachyarrhythmia, myocarditis, heart defects;
3. glaucoma;
4. decompensated diabetes mellitus, thyrotoxicosis;
5. liver or kidney failure;
6. peptic ulcer of the stomach and duodenum in the acute stage;
7. stomach bleeding;
8. arterial hypertension;

Pregnancy and lactation

Adequate and strictly controlled clinical studies of the safety of the use of Ascoril during pregnancy and during the period of feeding (breastfeeding) have not been conducted. In this regard, the use of Ascoril is possible only in cases where the potential benefit to the mother outweighs the expected risk to the fetus or child.

Side effect

Rarely: dyspeptic disorders, nausea, vomiting, diarrhea, exacerbation of gastric and duodenal ulcers, hand tremors, muscle cramps, allergic reactions (rash, urticaria).

When used in high doses- tachycardia, headache, dizziness, increased nervous excitability, sleep disturbance, drowsiness, peripheral vasodilation, decreased blood pressure, collapse.

Special instructions and precautions

Ascoril should be taken with caution in patients with hyperthyroidism, diabetes mellitus, severe diseases of the cardiovascular system, arterial hypertension, peptic ulcer of the stomach and duodenum.

drug interaction

With the simultaneous use of sympathomimetics (beta2-adrenergic agents) and theophylline enhance the effect and increase the likelihood of side effects of salbutamol, which is part of Ascoril.

Salbutamol, which is part of Ascoril, is not recommended for patients who receive MAO inhibitors.

Diuretics and glucocorticosteroid preparations enhance the hypokalemic effect of salbutamol.

Ascoril should not be used in combination with beta-blockers such as propranolol.
Ascoril is not prescribed simultaneously with preparations containing codeine and other antitussives, because. this makes it difficult to expel liquefied sputum.

Bromhexine, which is part of Ascoril, promotes the penetration of antibiotics (erythromycin, cephalexin, oxytetracycline) into the lung tissue.