Why do you need novocaine and instructions for use. Features of the use of novocaine intravenously Novocaine amp for what use

There are contraindications. Please consult your doctor before taking.

Commercial names abroad (abroad) - Allocaine, Gero, Geroaslan, Gerovital, Jenacaine, Neocaine, Nissocaine, Norocaine, Novanaest, Scurocaine, Spinocaine.

Currently, analogues (generics) of the drug are NOT FOR SALE in Moscow pharmacies!

All drugs used in neurology,.

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Preparations containing Procaine (Procaine, ATC code (ATC) N01BA02)

Novocaine (Procaine) - instructions for use. Prescription drug, information intended for healthcare professionals only!

Clinico-pharmacological group:

local anesthetic.

pharmachologic effect

A local anesthetic with moderate anesthetic activity and a wide range of therapeutic effects. Being a weak base, it blocks Na + - channels, prevents the generation of impulses at the endings of sensory nerves and the conduction of impulses along nerve fibers. Changes the action potential in the membranes of nerve cells without a pronounced effect on the resting potential. Suppresses the conduction of not only pain, but also impulses of a different modality.

With absorption and direct vascular injection into the bloodstream, it reduces the excitability of peripheral cholinergic systems, reduces the formation and release of acetylcholine from preganglionic endings (it has some ganglion-blocking effect), eliminates spasm of smooth muscles, and reduces the excitability of the myocardium and motor areas of the cerebral cortex.

Eliminates the descending inhibitory influences of the reticular formation of the brain stem. Inhibits polysynaptic reflexes. In high doses, it can cause convulsions. It has a short anesthetic activity (the duration of infiltration anesthesia is 0.5-1 h).

Pharmacokinetics

Undergoes complete systemic absorption. The degree of absorption depends on the site and route of administration (especially on vascularization and blood flow rate of administration) and the final dose (amount and concentration). It is rapidly hydrolyzed by plasma and liver esterases to form two main pharmacologically active metabolites: diethylaminoethanol (has a moderate vasodilating effect) and para-aminobenzoic acid (it is a competitive antagonist of sulfanilamide drugs and can weaken their antimicrobial effect). T1 / 2 - 30-50 s, in the neonatal period - 54-114 s. It is excreted mainly by the kidneys in the form of metabolites, no more than 2% is excreted unchanged.

Indications for the use of the drug NOVOCAINE

Infiltration, conduction, epidural and spinal anesthesia, intraosseous anesthesia, anesthesia of the mucous membranes (in ENT practice); vagosympathetic and pararenal blockade. Circular and paravertebral blockade in eczema, neurodermatitis, ischalgia.

Intravenously: to potentiate the action of the main means for anesthesia; for the relief of pain syndrome of various origins.

Intramuscularly: to dissolve penicillin in order to prolong its action; as an adjuvant for certain diseases that are more common in old age, incl. endarteritis, atherosclerosis, arterial hypertension, spasms of the coronary vessels and brain vessels, diseases of the joints of rheumatic and infectious origin.

Rectally: hemorrhoids, intestinal smooth muscle spasms, anal fissures.

Dosing regimen

For procaine solution 5 mg/ml (0.5%):

For infiltration anesthesia, 350-600 mg (70-120 ml) are administered. Higher doses for infiltration anesthesia for adults: the first single dose at the beginning of the operation is not more than 0.75 g (150 ml), then during each hour of the operation - not more than 2 g (400 ml) of the solution.

With pararenal blockade (according to A.V. Vishnevsky), 50-80 ml is injected into the perirenal tissue.

With circular and paravertebral blockade, 5-10 ml is injected intradermally. With vagosympathetic blockade, 30-40 ml is administered.

To reduce absorption and prolong the action during local anesthesia, an additional 0.1% solution of epinephrine hydrochloride is administered - 1 drop per 2-5-10 ml of procaine solution.

The maximum dose for use in children over 12 years old is 15 mg / kg.

For conduction and epidural anesthesia, a 2% solution is used.

Rectally. Having previously released the candle from the contour packaging with scissors (cutting the packaging along the contour of the candle), it is injected deep into the anus (after a cleansing enema or spontaneous bowel release) 1-2 times a day.

Side effect

From the side of the central and peripheral nervous system: headache, dizziness, drowsiness, weakness, lockjaw.

From the side of the cardiovascular system: an increase or decrease in blood pressure, peripheral vasodilation, collapse, bradycardia, arrhythmias, chest pain.

On the part of the hematopoietic organs: methemoglobinemia.

Allergic reactions: skin itching, skin rash, other anaphylactic reactions (including anaphylactic shock), urticaria (on the skin and mucous membranes). If during the use of the drug any of the side effects indicated in the instructions appear or they are aggravated, or you notice any other side effects not indicated in the instructions, tell your doctor about it.

Contraindications to the use of the drug NOVOCAINE

Hypersensitivity (including to para-aminobenzoic acid and other local anesthetic esters). Children's age up to 12 years.

For anesthesia by the method of creeping infiltrate - pronounced fibrous changes in the tissues.

Carefully. Emergency operations accompanied by acute blood loss; conditions accompanied by a decrease in hepatic blood flow (for example, chronic heart failure, liver disease); progression of cardiovascular insufficiency (usually due to the development of heart blocks and shock); inflammatory diseases or infection of the injection site; pseudocholinesterase deficiency; kidney failure; children's age from 12 to 18 years, old age (over 65 years); with caution in seriously ill and / or debilitated patients; during pregnancy and during childbirth.

The use of the drug NOVOCAINE during pregnancy and lactation

If it is necessary to prescribe the drug during pregnancy, the expected benefit to the mother and the potential risk to the fetus should be compared. With caution during childbirth.

If necessary, the use of the drug during lactation should decide on the termination of breastfeeding.

Application for violations of liver function

Use with caution in liver disease.

Application for violations of kidney function

Use with caution in renal failure.

Use in elderly patients

Use with caution in elderly patients (over 65 years).

Use in children under 12 years of age

Contraindicated in children under 12 years of age. Use with caution at the age of 12 to 18 years.

special instructions

Patients require monitoring of the functions of the cardiovascular system, the respiratory system and the central nervous system.

It is necessary to cancel monoamine oxidase inhibitors 10 days before the introduction of a local anesthetic.

It should be borne in mind that when performing local anesthesia using the same total dose, the toxicity of procaine is the higher, the more concentrated the solution is used.

Influence on the ability to drive vehicles and mechanisms

During the period of treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require an increased concentration of attention and speed of psychomotor reactions.

Overdose

Symptoms: pallor of the skin and mucous membranes, dizziness, nausea, vomiting, "cold" sweat, increased respiration, tachycardia, lowering blood pressure, up to collapse, apnea, methemoglobinemia. The action on the central nervous system is manifested by a feeling of fear, hallucinations, convulsions, motor excitation.

Treatment: maintaining adequate pulmonary ventilation, detoxification and symptomatic therapy.

drug interaction

Enhances the inhibitory effect on the central nervous system of drugs for general anesthesia, hypnotics, sedatives, narcotic analgesics and tranquilizers.

Anticoagulants (sodium ardeparin, sodium dalteparin, sodium danaparoid, sodium enoxaparin, sodium heparin, warfarin) increase the risk of bleeding. When treating the injection site with disinfectant solutions containing heavy metals, the risk of developing a local reaction in the form of pain and swelling increases.

Use with monoamine oxidase inhibitors (furazolidone, procarbazine, selegiline) increases the risk of developing a pronounced decrease in blood pressure. Enhances and prolongs the action of muscle relaxant drugs. Vasoconstrictors (epinephrine, methoxamine, phenylephrine) prolong the local anesthetic effect.

Procaine reduces the antimyasthenic effect of drugs, especially when used in high doses, which requires additional correction in the treatment of myasthenia gravis.

Cholinesterase inhibitors (antimiasthenic drugs, cyclophosphamide, demecarium bromide, ecothiopa iodide, thiotepa) reduce the metabolism of local anesthetic drugs.

The metabolite of procaine (para-aminobenzoic acid) is a sulfonamide antagonist.

Terms of dispensing from pharmacies

The drug is dispensed by prescription.

Terms and conditions of storage

Store the drug in a place protected from light, at a temperature not exceeding 25°C. Keep out of the reach of children.

Shelf life - 3 years. Do not use after the expiry date stated on the packaging.

Has pregnancy restrictions

Has restrictions on breastfeeding

Forbidden to children

Has restrictions for the elderly

Has limitations for liver problems

Has limitations for kidney problems

Novocaine is a synthetic drug that belongs to the pharmacological group of local anesthetic drugs. The drug locally exhibits analgesic properties after ingestion and absorption in the blood.

General information about the drug

This drug has the following effects on the human body:

• anti-inflammatory;
• antihistamine;
• analgesic;
• desensitizing;
• antitoxic;
• antispasmodic (on smooth muscle fibers);
• reduces the excitability of the muscle cells of the heart - cardiomyocytes.

medicinal group

Novocain belongs to the medicinal group of drugs for local anesthesia. It is prescribed to block nerve fibers and relieve painful syndromes of various etiologies. INN - Procaine.

The composition of the drug and its release form

The medicine is produced in the form of ampoules, cream, oil solution and in the form of suppositories:

The price of Novocaine in ampoules in pharmacies in Moscow

Novocain bufus 0.5% of Russian production in pharmacies costs 46.00 rubles.

Pharmacoproperties of the drug

The drug blocks the conduction of painful, irritable, spasmodic impulses through the nerve fibers. With intramuscular and intravenous administration, the excitability of cholinergic receptors in the peripheral parts of the nervous system decreases.

There is a decrease in the formation and release of acetylcholine molecules from the composition of preganglionic nerve endings. The drug blocks spasms of smooth muscle tissues, reduces the excitability of myocardial cells (cardiomyocytes) and reduces the excitability of the brain.

The use of Novocaine

Intravenous administration of the drug inhibits the reticular formation of the cerebral trunk. Novocaine inhibits polysynaptic nerve reflexes.

In high doses, the drug can cause convulsions. The drug has a short anesthetic time interval - from 30 minutes to 1 hour.

Pharmacokinetics of the drug:

• there is complete absorption in the body;
• absorption directly depends on the dosage and the place of administration of the drug (vascularization, the speed of blood flow through the main arteries). Also of no small importance in absorption is the way the drug enters the body;
• the drug is rapidly hydrolyzed in the blood plasma and liver cells into metabolites - diethylaminoetonol (has vasodilating properties);
• the half-life of the active substance from the body is from 30 to 50 minutes;
• the drug is excreted through the kidneys in the form of active metabolites with urine;
• no more than 2% is displayed in unchanged form.

Indications and limitations

The use of the drug is prescribed in such cases:

• vagosympathetic blockade procedure;
• pararenal blockade procedure;
• infiltration type of anesthesia;
• spinal anesthesia;
• peptic ulcer of the gastric mucosa;
• severe nausea.

Novocaine suppositories are used to relieve painful symptoms of hemorrhoids and fissures in the rectum.

Contraindications for use in the treatment of novocaine:

Novocaine can be used during pregnancy, but only as directed and under the supervision of a specialist. In childhood, the drug is used with caution from the age of 14.

Instructions for use

The method of drug administration is individual for each patient. For the conduction method of anesthesia, the minimum dosages are selected. The drug is administered: intradermally, by injection into a vein or by the method of internal injection into muscle fibers.

In accordance with the instructions for use, the recommended doses for injection:

The dosage should be reduced by 30% if the patient develops such pathologies:

• arterial occlusion;
• change in innervation;
• systemic atherosclerosis;
• type 1 and type 2 diabetes;
• violations of the liver;
• renal pathologies.

The maximum dosage of Novocain for use in therapy in children is 15 mg of the active substance per kilogram of the child's weight. For elderly patients, the dosage is adjusted in accordance with the development of chronic pathologies.

The drug must be used immediately after opening the ampoule. The remains of the medication must not be stored.

Side effects and overdose

When Novocaine is used in acceptable dosages and with the correct administration scheme, adverse reactions are rare, with the exception of patients with chronic pathologies and allergies. Possible side effects of the drug on the body:

An overdose is manifested in the following symptoms:

• pale skin color;
• dryness on mucous membranes;
• severe dizziness;
• nausea that leads to vomiting;
• increased sweating;
• paresthesia of the lips;
• cyanosis of the nasolabial region;
• a sharp decrease in blood pressure;
• numbness of the tongue and gums;
• tachycardia and rapid breathing;
• apnea:
• hallucinations;
• convulsive seizures;
• tremor;
• spontaneous twitching of the eyelids and limbs.

Overdose treatment is symptomatic therapy, and for more complex symptoms, oxygen inhalation and ventilation of the lungs.

Compatibility and analogues of the drug

It is important to consider the interaction of Novocaine with other medications:

• when combined therapy with anticoagulants - a high risk of heavy bleeding;
• during the period of therapy with muscle relaxants of a non-depolarizing type, Novocaine increases the period of their exposure;
• in the treatment with Physostigmine and anesthetics, their effect is enhanced;
• Atropine in joint therapy prolongs the effect on the body of procaine.

If it is necessary to replace Novocaine with other drugs of a similar effect, use:

general characteristics:

international and chemical names: o caine (procaine), (β-diethylaminoethyl ester of para-aminobenzoic acid hydrochloride);

Basic physical and chemical properties: colorless, transparent liquid (novocaine);

Compound: 1 ml of solution contains 2.5 or 5 mg of procaine;

excipients: water for injection, hydrochloric acid solution.

Release form. Injection.

Pharmacotherapeutic group. Preparations for local anesthesia. Esters of aminobenzoic acid.

ATC code N01BA02.

Pharmacological properties.

Pharmacodynamics. The mechanism of anesthetic action is associated with blockade of sodium channels, inhibition of potassium flow, competition with calcium, weakening of the surface tension of the phospholipid layer of membranes, inhibition of redox processes, and generation of impulses. Upon entering the blood, the drug reduces the formation of acetylcholine, reduces the excitability of peripheral cholinergic systems, has a blocking effect on the autonomic ganglia, reduces spasm of smooth muscles, reduces the excitability of the heart muscle and motor areas of the cerebral cortex.

Pharmacokinetics. In the body, the drug is quickly hydrolyzed, forming para-aminobenzoic acid and diethylaminoethanol.

Indications for use. Local anesthesia - mainly infiltration, as well as therapeutic blockades.

Dosage and administration. With local anesthesia, the dose of the drug depends on the concentration, the nature of the surgical intervention, the route of administration, the condition and age of the patient. With pararenal blockade, adults are injected with 50-70 ml of 0.5% or 100-150 ml of 0.25% novocaine solution. With vagosympathetic blockade, adults are injected with 30-100 ml of a 0.25% solution of novocaine. For infiltration anesthesia, the following higher doses are established (for adults): the first single dose at the beginning of the operation is not higher than 1.25 g of a 0.25% solution (i.e. 500 ml) and 0.75 g of a 0.5% solution (t e. 150 ml). In the future, during each hour of the operation - no more than 2.5 g of a 0.25% solution (i.e. 1000 ml) and 2 g of a 0.5% solution (i.e. 400 ml).

Side effect. As a rule, novocaine is well tolerated, but some patients experience increased sensitivity to the drug (dizziness, general weakness, lowering blood pressure, collapse, shock). Allergic skin reactions (dermatitis, peeling, swelling) may develop.

Contraindications. Hypersensitivity to the drug.

Overdose. In cases of overdose, the administration of the drug should be stopped immediately. During local anesthesia, the injection site can be punctured with adrenaline. When administered intravenously, forced diuresis is provided. Therapy is symptomatic.

Application features. It is administered with caution to patients with heart blockade, cardiac arrhythmias (especially bradycardia), patients with a burdened allergic history, as well as during lactation. To determine intolerance, a skin sensitivity test is first performed. To reduce and eliminate adverse reactions, antihistamines and corticosteroids are used. For surface anesthesia, it is of little use due to its poor ability to penetrate through intact mucous membranes.

Interaction with other drugs. The drug reduces the effect of anticholinesterase drugs on neuromuscular transmission. Intravenous administration of novocaine potentiates the effect of drugs used for anesthesia. To reduce the absorption and prolong the action of novocaine with local anesthesia, the introduction of novocaine is combined with the introduction of 0.15 adrenaline hydrochloride at the rate of 1 drop per 2-5-10 ml of novocaine. Novocaine reduces the effectiveness of sulfa drugs.

Storage conditions. Store in a dry, dark place, out of the reach of children, at a temperature not exceeding 25 ºС.

Best before date. 3 years.

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What is novocaine? A medical preparation of synthetic origin, unique in its composition, which is usually referred to as a group of agents for local anesthesia. It has a direct analgesic effect, which is observed after the absorption of the drug into the blood. A solution administered intravenously in the form of injections, with a volume of about five mg, also allows you to have an anti-inflammatory effect, as well as act as an analgesic, which can somewhat reduce the occurrence and development of spasms in the composition of smooth muscles.

Remarkably, novocaine, injections of which are carried out intravenously in accordance with the regulations of medical standards, provides a general decrease in the excitability of the heart muscle. Unlike the similar anesthetic drug cocaine, it has slightly less toxicity, but it also has less effect, which should be taken into account. The difference is observed in terms of about 10 times and this is the key difference between the drugs.

Application features

A solution of novocaine injections, which is taken based on the norm of five injections, is used, according to medical practice, for direct local anesthesia, as well as a number of anesthesias, such as Zakharyin-Ged zones, in dentistry and other situations. It is customary to use the drug intramuscularly, which will allow you to easily deliver the composition to the human body, and guarantee its subsequent anesthesia. In particular, intravenous novocaine is relevant for spinal anesthesia, which is the most difficult for a potential patient who visits a doctor. This drug is also relevant during the operation of tissue infiltration, when performing general anesthesia, when novocaine injections at a dosage of five mg are designed to provide the desired effect with minimal side effects.

Rules of application, individual feature, doctor's prescription

Some specific features have been developed and established, according to which novocaine injections of five mg intramuscularly are used. However, all the main definitions and specifics of the application are worked out directly by the attending physician. For this reason, before using novocaine in the form of mg injections, you will definitely need to undergo an appropriate consultation. We can distinguish the following features of the use of novocaine, through which it is important to distribute the rationing and subsequent supply of components in the right amount.

The following order of filing and normalization of the drug is determined:

• If it is necessary to ensure the supply of mg of novocaine when performing anesthesia of the corresponding zone of Zakharyin-Ged, it is customary to use a solution in a ratio of 0.25-0.5%. A similar dosage is also used during the mandatory novocaine blockade, which will eliminate the occurrence of side effects and pain.
• If necessary, spinal anesthesia, the dose of mg increases slightly, is in the range of 2-5%.
• Dentists also use injections of novocaine, while taking a solution of mg injections in a percentage of the order of no more than 2%.
• Conduction, as well as sacral anesthesia, will require the use of a mg solution in the range of 1-2%, depending on the complexity of the situation.

Such a decision and injection solution is made by the attending physician, who uses the results of previously compiled analyzes. Remarkably, there is a procedure for enhancing the effect of novocaine, as well as prolonging the action of the drug for local anesthesia, which, therefore, will guarantee an excellent painless effect. At the same time, adrenaline is used as an additional component, their ratio is one drop of the drug per injection solution of approximately 10 milliliters of the novocaine component. Similarly, and at the appropriate dosage, novocaine is actively used in therapy, which has made it an important component of treatment. The solution of the drug does not have side effects, subject to compliance with all necessary norms and conditions, dosage.

Novocain is an injection solution that is used as a local anesthetic. The use of the product is possible in dentistry, surgery and dermatology. The drug can be used externally as a compress. The drug has a number of contraindications that must be identified in the patient in advance in order to avoid the development of side effects.

The drug has several forms of release: suppositories and Novocaine solution. The liquid form and suppositories contain one active ingredient - procaine. Additional components (solid fat, distilled water, aqueous hydrogen chloride solution) may vary depending on the manufacturer.

Solution (0.25%, 0.5%, 2%) is a colorless (rarely yellowish) transparent liquid, poured into glass ampoules of 10 ml, 5 ml or 2 ml. There is a scarifier in the cardboard box. Torpedo-shaped suppositories are sold in plastic pallets of 10 pcs. in everyone.

Pharmacological properties

Novocaine intravenously as an anesthetic has moderate activity. The drug stops pain attacks and impulses of different modality. When released into the blood, the main component reduces the rate of release and production of choline derivatives. With absorption, the degree of excitability of cholinergic neurons decreases.

The drug is able to smooth out the muscles, lowers the level of excitability of the motor areas of the brain and myocardium. Polysynaptic reflexes are inhibited, any inhibitory downward influences are eliminated. Novocaine used in high doses can cause convulsions.

Duration of action - no more than 60 minutes. Anesthetic activity is short-term. The main component is completely absorbed. The level of absorption depends on the place of administration (intramuscularly, in a vein or by means of a dropper) and the dose of the drug. Hydrolysis is fast, in the process para-aminobenzoic acid and diethylaminoethanol are formed. The latter has a slight vasodilating effect.

Indications and contraindications

The use of injections with Novocain is possible with the following types of anesthesia:

• spinal;
• conductive;
• epidural;
• intraosseous;
• infiltration.

A 0.5% solution is used in otolaryngology for anesthesia of the mucous membranes of the nose and mouth. With its help, blockade is carried out:

• circular;
• paravertebral;
• vagosympathetic cervical;
• pararenal.

The drug for anesthesia is combined with the main anesthetic drugs. When administered intramuscularly, the drug accelerates the dissolution of penicillin. Novocaine is used for the following pathologies:

• rheumatic and infectious diseases of the joints;
• high blood pressure (hypertension);
• vascular spasms;
• endarteritis;
• atherosclerosis.

The medicine is effective for toothache. You can use a solution for compresses for diseases of the skin. Suppositories help with anal fissures and hemorrhoids.

The drug has a number of absolute and relative contraindications for use. The absolute ones are:

• individual intolerance to procaine;
• childhood;
• kidney failure;
• inflammatory pathologies;
• lack of pseudocholinesterase;
• progressive cardiovascular insufficiency;
• slow blood flow in the liver;
• emergency operations accompanied by blood loss.

Relative contraindications include pregnancy, a tendency to allergic reactions and old age.

Application instruction of Novocaine in ampoules

The use of the drug should be carried out only according to the instructions. Before administering the medication, the doctor should ask the patient in detail about possible contraindications. The treatment regimen, course and dosage are selected individually, taking into account the age of the patient.

How to breed?

The pure solution does not need to be diluted with anything. If necessary, antibiotics are diluted with Novocaine.

Dosage and administration

For children over 12 years of age, the maximum daily dose is 5 mg/kg body weight. To prolong the effect and reduce the absorption rate of Novocain during anesthesia, epinephrine hydrochloride 0.1% (one drop per 5-10 ml). With paravertebral and circular blockade, the solution is administered intradermally (5-10 ml each). With vagosympathetic blockade, the rate is increased by 3-4 times (once no more than 40 ml).

Pararenal blockade involves the introduction of a solution into the perirenal zone (no more than 80 ml once). With infiltration anesthesia, Novocain 0.5% is used, the maximum dose is 600 ml. Before surgery, adult patients are injected with 150 ml of solution. During the operation (every hour) another 400 ml is poured through a dropper.

Side effects and overdose

The risk of developing side effects increases if an individually selected treatment regimen is not followed. They come from:

1. Cardiovascular system: aching chest pain, collapse, arrhythmia, peripheral vasodilation, bradycardia, blood pressure surges.
2. Hematopoietic systems: methemoglobinemia.
3. Central nervous system: weakness, drowsiness, dizziness, prolonged headaches.

Most often, patients complain of the appearance of characteristic allergy symptoms, which include urticaria, itching, and skin rashes. In rare cases, anaphylactic shock is possible. Side effects are reversible, they disappear on their own after stopping treatment.

Symptoms of an overdose appear when the daily norm is repeatedly exceeded. Main features:

• motor excitation;
• auditory and visual hallucinations;
• feeling of fear and anxiety;
• apnea;
• a sharp drop in blood pressure;
• respiratory failure (up to asthma attacks);
• tachycardia;
• increased sweating ("cold" sweat);
• uncontrolled vomiting;
• dizziness (up to fainting);
• bouts of nausea;
• pallor of the skin.

Gastric lavage will not help in this case. Symptomatic treatment is required: the patient should be immediately taken to the nearest medical facility, where doctors are able to maintain pulmonary ventilation and, if necessary, prescribe detoxification therapy.

special instructions

The solution is not recommended to be instilled into the eyes without the consent of the attending physician. If the patient was prescribed electrophoresis for osteochondrosis, then the procedure is carried out only after the diagnosis has been clarified and under the supervision of a specialist. During the period of treatment, it is recommended to refuse to drive a car and other vehicles: the drug can reduce concentration. Procaine does not penetrate well through intact mucous membranes, therefore, with its help, superficial anesthesia is not performed.

2 weeks before the start of treatment, monoamine oxidase inhibitors should be discontinued. The systematic use of novocaine requires regular monitoring of the functions of the respiratory and nervous system, heart and blood vessels. Before administering the solution to the patient, it is necessary to conduct an individual test for sensitivity. The drug is incompatible with alcohol. 7 days before the start of treatment, the patient must completely refrain from drinking alcohol (including low alcohol).

Appointment during pregnancy and lactation

Before prescribing Novocaine to a pregnant or breastfeeding woman, the doctor must calculate the possible risks in advance. In the postpartum period, a careful reception is necessary: ​​injections are placed under the supervision of a doctor. If there is a need for a breastfeeding woman to use the drug, then lactation should be stopped.

Interaction with other drugs

Cholinesterase inhibitors can slow down the metabolism of Novocaine. The metabolite of procaine (para-aminobenzoic acid) is considered a sulfonamide antagonist. Under the influence of novocaine, the degree of anti-myasthenic effects of some drugs decreases, so it may be necessary to correct therapy for myasthenia gravis. Vasoconstrictors (methoxamine, epinephrine, phenylephrine) prolong the anesthetic effect.

Under the influence of Novocaine, muscle relaxant drugs increase their bioavailability. The drug has a negative compatibility with monoamine oxidase inhibitors due to the high likelihood of a sharp decrease in blood pressure. The injection site of the solution cannot be treated with disinfectant solutions: they contain heavy metals, so the risk of bruising increases.

Novocaine can not be combined with anticoagulants: internal bleeding may open. The drug enhances the effect of analgesics, tranquilizers, hypnotics and sedatives.

Terms of sale and storage

Novocaine as a local anesthetic can only be purchased with a doctor's prescription, written in Latin on a special endorsed form. Approximate cost - from 25 rubles. for packing. Opened boxes with ampoules and suppositories must be properly stored so that the medicine does not lose its properties. Shelf life - no more than 36 months. The storage location must be dry and dark. The drug should be protected from children, fire, sunlight and pets.

Analogues (briefly)

In the pharmacy, you can purchase a number of medicines that provide the same therapeutic effect as the original drug. These include:

1. Dekain. A local anesthetic in the form of a solution quickly anesthetizes the mucous membranes, reducing the sensitivity of the nerve endings. It is used in otolaryngology and ophthalmology. If the patient has contraindications to amide anesthetics, the drug is used for spinal anesthesia. Price - from 45 rubles.
2. Anestezin. The tablet form of the drug provides local anesthesia. Contains benzocaine. Tablets are dissolved in liquid and used as directed. Oral administration is possible for pathologies of the digestive tract. The cost is from 50 rubles.
3. Pyromecaine. Produced in the form of a gel, it is used mainly in dentistry. The active ingredients are methyluracil and bumecaine. The drug provides local anesthesia for stomatitis, erythema and periodontitis. Price - from 220 rubles.
4. mepivacaine. Amide anesthetic is sold in the form of a solution. The main element is the substance of the same name in the form of hydrochloride. There are no vasoconstrictor components in the composition. The drug is used in surgery, otolaryngology and dentistry. The cost is from 140 rubles.

Generics have contraindications, which the doctor must take into account when prescribing. Self-selection of medication is strictly prohibited.