ALT and AST
11.10.2020

Phosphalugel after how much it starts to act. Phosphalugel: what does this remedy help with? Phosphalugel appointment

Phosphalugel is an antacid drug that also has an enveloping and adsorbing effect..

The composition of the drug includes the active substance - aluminum phosphate.


Phosphalugel neutralizes free hydrochloric acid in the stomach, and also reduces the activity of pepsin. Within 10 minutes, the drug reduces the acidity to a level of 3.5-5. At the same time, the antacid effect of Phosphalugel is not associated with alkalization of gastric juice, and secondary hypersecretion of HCl does not occur.

The drug is not able to be absorbed in the gastrointestinal tract. Due to the adsorbing effect, when Phosphalugel is used, bacteria, gases, toxins, and viruses are removed from the gastrointestinal tract. Also characteristic is the normalization of the passage of the contents of the gastrointestinal tract when taking Phosphalugel.

Indications for the use of Phosphalugel

The instructions for Phosphalugel indicate the following indications for use:

  • chronic gastritis (normal or increased secretion);
  • acute gastritis;
  • acute duodenitis;
  • symptomatic ulcer of various etiologies;
  • peptic ulcer of the stomach and duodenum;
  • erosion of the gastrointestinal mucosa;
  • hiatal hernia;
  • reflux esophagitis (including in childhood);
  • non-ulcer dyspepsia syndrome;
  • colopathy;
  • functional pathology of the large intestine;
  • enterocolitis;
  • proctitis;
  • sigmoiditis;
  • diverticulitis;
  • poisoning;
  • diarrhea after gastrectomy;
  • acute, chronic pancreatitis;
  • heartburn caused by excessive consumption of coffee, nicotine, ethanol, errors in the diet, taking medications;
  • gastralgia;
  • symptoms of damage to the gastrointestinal tract when taking medicines, alkalis, acids;
  • dyspepsia of neurotic etiology;
  • prevention of absorption of radioactive elements.

Contraindications to the use of Phosphalugel

According to the instructions, Phosphalugel is contraindicated in:

  • hypersensitivity to components;
  • chronic renal failure;
  • Alzheimer's disease;
  • hypophosphatemia.

According to strict indications, Phosphalugel can be prescribed in childhood (up to 12 years) and old age.

Side effect

When taking this drug, a number of side effects may develop, which cause negative feedback about Phosphalugel from patients. The following side effects have been registered: vomiting, nausea, constipation, changes in taste, allergic reactions. To prevent the development of side effects, it is necessary to use Phosphalugel only as prescribed by a doctor and follow the dosage regimen.

With prolonged use of Phosphalugel at a high dosage, hypocalcemia, hypophosphatemia, hypercalciuria, osteoporosis, osteomalacia, hyperaluminemia, nephrocalcinosis, encephalopathy may develop.

Phosphalugel overdose

Phosphalugel overdose symptoms - constipation. Treatment is the use of laxatives.

When using the drug for more than two weeks, the development of a chronic overdose (Newcastle bone disease) is possible. Symptoms: hypophosphatemia (myasthenia gravis, malaise, osteoporosis, osteomalacia); kidney failure; aluminum encephalopathy (apraxia, dysarthria, dementia, convulsions).

How to use Phosphalugel, dosage

Phosphalugel is intended for oral administration. The drug can be used in pure form or diluted in water.

A single dosage of Phosphalugel is 1-2 sachets (1 sachet contains 8.8 g of active ingredient). The frequency of admission is two to three times a day. In case of poisoning, burns with caustic drugs, the dosage is 3-5 sachets at a time.

With reflux esophagitis, ulcerative lesions of the gastrointestinal tract, Phosphalugel is taken at bedtime or two hours after a meal, with pain - immediately. With diaphragmatic hernia, the drug is recommended to be taken immediately after meals, as well as at bedtime, with enterocolitis - before meals twice a day, with colopathy - before breakfast and at bedtime.

The duration of Phosphalugel therapy is determined by the doctor based on the symptoms of the disease.

According to the indications, Phosphalugel can be used in pediatrics in the following dosages: at the age of up to 6 months - 4 g or a teaspoon after each feeding (6 times); after 6 months - 8g or 2 teaspoons after each feeding (4 times).

Interaction of Phosphalugel with other drugs

Phosphalugel is able to reduce or slow down the absorption of indomethacin, digoxin, salicylates, phenytoin, chlorpromazine, antihistamines, diflunisal, beta-blockers, isoniazid, azithromycin, tetracyclines, cefpodoxime, rifampicin, barbiturates, indirect anticoagulants, ursodeoxycholic and chenodez hydroxycholic acid, lansoprazole, penicillamine. M anticholinergics lengthen and enhance the action of Phosphalugel and analogues.

special instructions

If it is necessary to use Phosphalugel for a long time, it is necessary to ensure a sufficient level of phosphate intake in the body.

With an unspecified diagnosis, long-term use of Phosphalugel is not recommended.

According to the indications, Phosphalugel can be prescribed to patients with diabetes mellitus, since the drug does not contain sugar.

Phosphalugel can be prescribed together with cimetidine, disopyramide, ketoprofen, amoxicillin, prednisolone.

Taking Phosphalugel does not affect the X-ray data.

The use of Phosphalugel during pregnancy

There are no reliable data on the safety of using the drug during pregnancy and lactation. According to clinical studies, according to strict indications, Phosphalugel can be used occasionally during pregnancy and lactation.

Phosphalugel release form

The drug is available in the form of a 20% oral gel in sachets containing 2.08 and 2.48 g of the active ingredient.

The contents of the sachet must be thoroughly kneaded between the fingers before use.

  • Antacids

    • Composition and form of release

    in a box of 20 or 26 pcs. in a box of 20 or 26 pcs.

    Description of the dosage form

    White or almost white homogeneous gel, sweet taste, with a taste and smell of orange.

    pharmachologic effect

    Pharmacological effect - antacid, enveloping, adsorbing.

    Pharmacodynamics

    It has an acid-neutralizing, enveloping, adsorbing effect. Reduces the proteolytic activity of pepsin. Does not cause alkalization of gastric juice, keeping the acidity of gastric contents at the physiological level. Does not lead to secondary hypersecretion of hydrochloric acid. Forms a protective layer on the mucous membrane of the gastrointestinal tract. Helps to remove toxins, gases and microorganisms throughout the digestive tract, normalizes the passage of contents through the intestines.

    Phosphalugel indications

    For adults: peptic ulcer of the stomach and duodenum; gastritis with regular or increased secretory function; diaphragmatic hernia; reflux esophagitis; non-ulcer dyspepsia syndrome; functional diarrhea; gastric and intestinal disorders caused by intoxication, taking medications, irritating substances (acids, alkalis ), alcohol. For children: esophagitis; gastroesophageal reflux; gastritis; peptic ulcer of the stomach and duodenum.

    Contraindications

    hypersensitivity to the drug; severe renal dysfunction.

    Use during pregnancy and lactation

    Probably use during pregnancy and during breastfeeding according to indications, in therapeutic doses.

    Side effects

    Constipation (rare, usually in elderly people and bedridden patients).

    Interaction

    Antibiotics of the tetracycline group, iron preparations, cardiac glycosides should be taken no earlier than 2 hours after taking Phosphalugel.

    Dosage and administration

    inside, it is possible in its pure form or diluted in half a glass of water before taking. Adults and children over 6 years old - 1-2 packs. 2-3 times a day; with gastroesophageal reflux, diaphragmatic hernia - immediately after meals and at night; with peptic ulcer of the stomach and duodenum - 1-2 hours after eating and immediately if pain occurs; with gastritis and dyspepsia - before meals; with functional diseases of the colon - in the morning before meals and at night. The medication is repeated if the pain appears in the intervals between doses. Children: up to 6 months - 4 g (1/4 pack or 1 teaspoon) after each of 6 feedings; after 6 months - 8 g (1/2 pack or 2 teaspoons) after each of 4 feedings.

    Overdose

    Symptoms: inhibition of gastrointestinal motility (due to the large amount of aluminum ions). Treatment: prescription of laxatives.

    Precautionary measures

    Do not take the drug for a long time without a doctor's prescription. Use with caution in the presence of kidney disease, liver cirrhosis, severe heart failure. In elderly patients and those with impaired renal function, when Phosphalugel is used at recommended doses, an increase in the concentration of aluminum in the blood serum is likely. during periods of pregnancy and lactation according to indications.

    special instructions

    With constipation, which occasionally occurs when taking Phosphalugel, it is proposed to increase the amount of daily water consumed. The drug can be used by patients suffering from diabetes; prophylactically to reduce the absorption of radioactive elements. The use of Phosphalugel does not affect the results of an X-ray examination. When using Phosphalugel simultaneously with other medicinal drugs, you should consult a doctor, since Phosphalugel reduces the effectiveness of some drugs.

    Storage conditions of the drug Phosphalugel

    At a temperature of 15-25 °C.

    Keep out of the reach of children.

    Shelf life of the drug Phosphalugel

    Do not use after the expiry date stated on the packaging.

    Composition and form of release

    in a box of 20 or 26 pcs.

    in a box of 20 or 26 pcs.

    Description of the dosage form

    White or almost white homogeneous gel, sweet taste, with a taste and smell of orange.

    pharmachologic effect

    pharmachologic effect- absorbent, enveloping, antacid    .

    Pharmacodynamics

    It has an acid-neutralizing, enveloping, adsorbing effect. Reduces the proteolytic activity of pepsin. Does not cause alkalization of gastric juice, keeping the acidity of gastric contents at the physiological level. Does not lead to secondary hypersecretion of hydrochloric acid.

    Forms a protective layer on the mucous membrane of the gastrointestinal tract.

    Promotes the removal of toxins, gases and microorganisms throughout the digestive tract, normalizes the passage of contents through the intestines.

    Phosphalugel indications

    For adults:

    peptic ulcer of the stomach and duodenum;

    gastritis with normal or increased secretory function;

    diaphragmatic hernia;

    reflux esophagitis;

    non-ulcer dyspepsia syndrome;

    functional diarrhea;

    gastric and intestinal disorders caused by intoxication, taking medications, irritants (acids, alkalis), alcohol.

    For children:

    esophagitis;

    gastroesophageal reflux;

    peptic ulcer of the stomach and duodenum.

    Contraindications

    hypersensitivity to the drug;

    severe renal dysfunction.

    Use during pregnancy and lactation

    It is possible to use during pregnancy and during breastfeeding according to indications, in therapeutic doses.

    Side effects

    Constipation (rare, mainly in the elderly and bedridden patients).

    Interaction

    Dosage and administration

    inside, can be in pure form or diluted in half a glass of water before taking. Adults and children over 6 years old - 1-2 packs. 2-3 times a day; with gastroesophageal reflux, diaphragmatic hernia - immediately after meals and at night; with peptic ulcer of the stomach and duodenum - 1-2 hours after eating and immediately if pain occurs; with gastritis and dyspepsia - before meals; with functional diseases of the colon - in the morning on an empty stomach and at night. The drug is repeated if pain occurs in the intervals between doses.

    Children: up to 6 months - 4 g (1/4 pack or 1 teaspoon) after each of 6 feedings; after 6 months - 8 g (1/2 pack or 2 teaspoons) after each of 4 feedings.

    Overdose

    Symptoms: inhibition of gastrointestinal motility (due to the large amount of aluminum ions).

    Treatment: prescription of laxatives.

    Precautionary measures

    Do not take the drug for a long time without a doctor's prescription. Use with caution in the presence of kidney disease, liver cirrhosis, severe heart failure. In elderly patients and patients with impaired renal function, when using Phosphalugel at recommended doses, an increase in the concentration of aluminum in the blood serum is possible.

    Antibiotics of the tetracycline group, iron preparations, cardiac glycosides should be taken no earlier than 2 hours after taking Phosphalugel.

    It is possible to use the drug in therapeutic doses during periods of pregnancy and lactation according to indications.

    special instructions

    With constipation, which occasionally occurs when taking Phosphalugel, it is recommended to increase the amount of daily water consumed.

    The drug can be used by patients suffering from diabetes; prophylactically to reduce the absorption of radioactive elements.

    The use of Phosphalugel does not affect the results of x-ray examination.

    When using Phosphalugel simultaneously with other drugs, you should consult your doctor, since Phosphalugel reduces the effectiveness of some drugs.

    Storage conditions of the drug Phosphalugel

    At a temperature not higher than 25 °C.

    Keep out of the reach of children.

    Shelf life of the drug Phosphalugel

    3 years.

    Do not use after the expiry date stated on the packaging.

    Synonyms of nosological groups

    Category ICD-10Synonyms of diseases according to ICD-10
    A05.9 Bacterial food poisoning, unspecifiedBacterial intoxications
    Diarrhea due to food intoxication
    Acute diarrhea due to food poisoning
    food intoxication
    food poisoning
    Food poisoning
    food poisoning
    Food poisoning
    food poisoning
    Toxic diarrhea
    K21 Gastroesophageal refluxBiliary reflux esophagitis
    Gastroesophageal reflux disease
    Gastrocardiac syndrome
    Gastroesophageal reflux disease
    Gastroesophageal reflux
    non-erosive reflux disease
    Syndrome gastrocardiac
    Roemheld syndrome
    Erosive reflux esophagitis
    Ulcerative reflux esophagitis
    K25 Gastric ulcerHelicobacter pylori
    Pain syndrome in gastric ulcer
    Inflammation of the stomach lining
    Inflammation of the gastrointestinal mucosa
    benign stomach ulcer
    Exacerbation of gastroduodenitis on the background of peptic ulcer
    Exacerbation of peptic ulcer
    Exacerbation of gastric ulcer
    Organic gastrointestinal disease
    Postoperative gastric ulcer
    Ulcer recurrence
    Symptomatic stomach ulcers
    Helicobacteriosis
    Chronic inflammatory disease of the upper gastrointestinal tract associated with Helicobacter pylori
    Erosive and ulcerative lesions of the stomach
    Erosive lesions of the stomach
    Erosion of the gastric mucosa
    peptic ulcer
    Stomach ulcer
    Ulcerative lesion of the stomach
    Ulcerative lesions of the stomach
    K26 Duodenal ulcerPain syndrome in duodenal ulcer
    Pain syndrome in peptic ulcer of the stomach and duodenum
    Disease of the stomach and duodenum associated with Helicobacter pylori
    Exacerbation of peptic ulcer
    Exacerbation of duodenal ulcer
    Peptic ulcer of the stomach and duodenum
    Recurrent duodenal ulcer
    Symptomatic ulcers of the stomach and duodenum
    Helicobacteriosis
    Helicobacter pylori eradication
    Erosive and ulcerative lesions of the duodenum
    Erosive and ulcerative lesions of the duodenum associated with Helicobacter pylori
    Erosive lesions of the duodenum
    Peptic ulcer of the duodenum
    Ulcerative lesions of the duodenum
    K29.6.1* Hyperacid gastritisPain in acute gastritis with high acidity
    Gastritis with high acidity
    Gastritis with increased secretory function
    Gastritis chronic hypersecretory
    Hyperacid gastritis
    Hyperacid gastritis
    K30 DyspepsiaFermentative dyspepsia
    Hyperacid dyspepsia
    Putrid dyspepsia
    Dyspepsia
    Dyspepsia
    Dyspepsia of nervous origin
    Dyspepsia of pregnant women
    Dyspepsia fermentation
    Dyspepsia putrefactive
    Dyspepsia drug
    Dyspepsia due to gastrointestinal disease
    Dyspepsia due to GI dysmotility
    Dyspepsia due to unusual food or overeating
    Dyspeptic phenomena during pregnancy
    Dyspeptic syndrome
    Dyspeptic disorder
    gastric dyspepsia
    Delayed gastric emptying
    slow digestion
    Idiopathic dyspepsia
    acid dyspepsia
    Upper GI dysmotility
    Indigestion
    Nervous dyspepsia
    Non-ulcer dyspepsia
    Feeling of heaviness in the stomach after eating
    Postprandial functional dyspepsia
    Fermentation processes in the intestines
    Stomach disorders
    Gastrointestinal disorders
    Disorders of the digestive process
    Disorders from the gastrointestinal tract
    Stomach upset
    indigestion
    Indigestion in infants
    Symptoms of dyspepsia
    Syndrome of putrefactive dyspepsia
    Syndrome of putrefactive dyspepsia in young children
    Digestive insufficiency syndrome
    Non-Ulcer Dyspepsia Syndrome
    Toxic dyspepsia
    functional dyspepsia
    Functional digestive disorders
    chronic dyspepsia
    Chronic episodes of dyspepsia
    Essential dyspepsia
    K31.8.2* Hyperacidity of gastric juiceHyperacid dyspepsia
    hyperacid state
    Hyperacid states
    Hyperacidosis
    Hypersecretion of gastric juice
    Pathological hypersecretion
    Acidity
    Increased acidity of the stomach
    Increased secretion of gastric juice
    Increased acid production
    K44 Diaphragmatic herniaDiaphragmatic hernia
    hiatal hernia
    Hiatal hernia
    K59.1 Functional diarrheadiarrheal syndrome
    Diarrhea
    Diarrhea of ​​non-infectious origin
    Diarrhea after gastrectomy
    Diarrhea with long-term enteral feeding through a tube
    Diarrhea with electrolyte imbalance
    Diarrhea in children
    prolonged diarrhea
    Nonspecific diarrhea
    Acute diarrhea
    Persistent diarrhea
    Diarrhea
    Diarrhea (diarrhea)
    diarrhea syndrome
    functional diarrhea
    chronic diarrhea
    Chronic diarrhea
    Enterocolitis of non-infectious origin
    T50.9 Other and unspecified drugs, medicaments and biological substancesCorrection of side effects of drugs
    drug intoxication
    Drug intoxication
    Acute drug poisoning
    Acute drug poisoning
    Acute poisoning with potent and toxic substances
    Drug poisoning
    Oxalate poisoning
    Poisoning with iodine preparations
    Poisoning by caustic liquids
    Poisoning with potent and toxic substances
    T51 Toxic effect of alcoholAlcohol intoxication
    alcohol intoxication
    Alcohol intoxication
    Acute alcohol intoxication
    Chronic alcohol intoxication
    Y57.9 Adverse reactions in therapeutic use of drugs and medicaments, unspecifiedAllergic drug reactions
    Allergic reactions to drugs
    Allergic reactions to drugs
    Allergic reactions to medications
    Allergic reactions to drugs
    Allergic reactions to radiopaque agents
    Allergic reactions due to medication
    drug allergy
    Anaphylactic drug reactions
    Anaphylactic reactions to drugs
    Hepatotoxic substances
    Hepatotoxic effect of drugs
    Diarrhea medication
    Idiosyncrasy to drugs
    Idiosyncrasy toxic
    drug addiction
    drug leukopenia
    medicinal fever
    drug intolerance
    Drug-induced liver injury
    Drug-induced lung disease
    Undesirable drug effects
    Acute allergic reaction to drugs
    Toxic reactions to drugs

    Aluminum phosphate (aluminum phosphate)

    Composition and form of release of the drug

    ◊ Gel for oral administration white or almost white, homogeneous after mixing, with an orange smell.

    Excipients: sorbitol solution 70% - 4.286 g, agar-agar 800 - 0.08 g, pectin - 0.1 g, calcium sulfate dihydrate - 0.01 g, potassium sorbate - 0.053 g, orange flavor - 0.032 g, purified water - up to 20 g.

    20 g - sachets (sachets) multilayer heat-sealed (20) - packs of cardboard.

    pharmachologic effect

    An antacid. Neutralizes hydrochloric acid of gastric juice and reduces the proteolytic activity of pepsin. It is practically not absorbed from the gastrointestinal tract and does not cause alkalosis. Being adsorbed on the gastric mucosa in the form of hydrophilic colloidal micelles, aluminum phosphate creates a protective mucoid layer that protects the mucosa from the effects of hydrochloric acid, pepsin, endogenous and exogenous toxic substances.

    Does not cause phosphate deficiency in the body.

    Pharmacokinetics

    When taken orally, it has low absorption. Most of the aluminum phosphate is insoluble, a small part is precipitated in the intestine in the form of oxides and insoluble carbonates.

    Indications

    Peptic ulcer of the stomach and duodenum in the acute phase, chronic with increased and normal secretory function of the stomach in the acute phase, acute gastritis, acute duodenitis, symptomatic ulcers of various origins, erosion of the gastrointestinal mucosa, hiatal hernia, enterocolitis, sigmoiditis, proctitis, diverticulitis , diarrhea in patients after gastrectomy, dyspeptic phenomena (including neurotic genesis, after errors in diet, medication, chemotherapy), acute pancreatitis, chronic pancreatitis in the acute phase, poisoning and intoxication.

    For the purpose of prevention to reduce the absorption of radioactive elements.

    Contraindications

    Dosage

    Individual. The dose is set depending on the dosage form used and indications.

    Side effects

    From the digestive system:(especially in the elderly and bedridden patients), nausea, vomiting, changes in taste sensations.

    From the side of laboratory indicators: with prolonged use in high doses - hypophosphatemia, hypocalcemia, increased levels of aluminum in the blood.

    From the musculoskeletal system: osteomalacia, osteoporosis.

    From the side of the central nervous system: encephalopathy.

    From the urinary system: hypercalciuria, nephrocalcinosis, renal failure.

    drug interaction

    Aluminum preparations, which are used both, interact with most drugs for oral administration, both by changing the pH of gastric juice and rapid gastric emptying, and by adsorption to form complexes that are not absorbed.

    With the simultaneous use of citrates, they increase the absorption of aluminum from the gastrointestinal tract.



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