Hexoral: instructions for use, analogues and reviews, prices in Russian pharmacies. Hexoral spray - instructions for use Hexoral spray instructions for use

Tradename: Hexoral®.

International nonproprietary name: hexethidine.

Dosage form: aerosol for topical use.

Compound

Active substance: hexethidine 0.2%.

Excipients: citric acid, monohydrate; sodium saccharin, sodium hydroxide, glycerol, lauromacrogol (Laureth 23), mint flavor (33C071) (menthol, peppermint oil, anethole, eucalyptol, ethyl formate, propylene glycol), purified water.

Description:

Transparent syrupy liquid, almost colorless, with a menthol odor.

Pharmacological properties

Pharmacotherapeutic group: antiseptic.

ATX code: A01AB12.

Pharmacodynamics

The antimicrobial effect of the drug "Hexoral" is associated with the suppression of oxidative reactions of bacterial metabolism (thiamine antagonist). The drug has a wide spectrum of antibacterial and antifungal effects, in particular against gram-positive bacteria and fungi of the genus Candida, however, Hexoral can also have an effect in the treatment of infections caused, for example, by Pseudomonas aeruginosa or Proteus. At a concentration of 100 mg/ml, the drug inhibits most strains of bacteria. No development of resistance was observed. Hexethidine has a weak anesthetic effect on the mucous membrane.

Pharmacokinetics

Hexethidine adheres very well to the mucous membrane and is practically not absorbed. After a single use of the active substance, traces of it are found on the gum mucosa within 65 hours. In plaques on teeth, active concentrations remain for 10–14 hours after application.

Indications for use

Inflammatory and infectious diseases of the oral cavity and pharynx; in the complex treatment of severe febrile or purulent diseases of the oral cavity and pharynx, requiring the use of antibiotics and sulfonamides, tonsillitis; tonsillitis (including tonsillitis with damage to the lateral ridges, Plaut-Vincent's tonsillitis); pharyngitis; gingivitis and bleeding gums; periodontopathies (periodontal diseases and their symptoms); stomatitis (inflammation of the oral mucosa), glossitis (inflammation of the tongue), aphthous ulcers (painful inflammation with superficial tissue defects) to prevent superinfections; infection of the alveoli (sockets of teeth) after tooth extraction; fungal infections of the oral cavity and pharynx, especially candidal stomatitis (thrush); before and after operations in the oral cavity and pharynx; additional oral hygiene for general diseases; elimination of bad breath, especially in the case of decaying tumors of the oral cavity and pharynx; an aid in the treatment of colds.

Contraindications

Hypersensitivity to any of the components of the drug; children under 3 years of age. Pregnancy and lactation There is no information about any harmful effects of the drug Hexoral during pregnancy and breastfeeding. However, before prescribing Hexoral to pregnant or lactating women, the doctor must carefully weigh the benefits and risks of treatment, given the lack of sufficient data on the penetration of the drug through the placenta and into breast milk.

Directions for use and doses

Adults and children over 3 years of age A single dose is administered over 1–2 s.

Unless otherwise indicated, apply twice daily, preferably morning and evening. Hexethidine adheres to the mucous membrane and due to this gives a lasting effect. In this regard, the drug should be used after meals. The drug "Hexoral" aerosol for topical use is also safe with more frequent use.

The drug is sprayed into the mouth or throat. Using an aerosol you can easily and quickly treat the affected areas. It is necessary to perform the following steps: install the aerosol tube into the corresponding hole in the upper part of the bottle, lightly pressing on it, pointing the tip of the tube away from you; hold the aerosol tube as shown in the figure, point the tube at the affected area of ​​the mouth or pharynx; during administration, the bottle should be kept in an upright position at all times; inject the required amount of the drug by pressing on the head for 1–2 s, do not breathe when administering the aerosol.

The duration of treatment is determined by the doctor.

Do not use in children under 3 years of age.

Side effect

In some cases, hypersensitivity reactions to the drug developed. With prolonged use, taste disturbance may occur.

Overdose

Hexethidine in the indicated dosage is non-toxic. Ingestion of large quantities of the drug results in vomiting, so significant absorption is not expected. In any case of overdose, consult your doctor immediately. Gastric lavage is necessary within 2 hours after ingestion of an excess dose.

Interaction with other drugs

Not described.

special instructions

There are no special instructions.

Children can use the drug from an age when there is no danger of uncontrolled swallowing or when they do not resist a foreign object (applicator) in the mouth when using the aerosol and are able to hold their breath when injecting the drug.

Release form

Aerosol for topical use 0.2%. 40 ml in an aluminum aerosol can. 1 bottle complete with a spray nozzle along with instructions for use in a cardboard box.

Storage conditions

Store at a temperature not exceeding 25°C.

Keep out of the reach of children.

Best before date

Do not use the drug after the expiration date indicated on the package.

Conditions for dispensing from pharmacies

Dispensed from pharmacies without a prescription.

Manufacturer: Pfizer PGM, France

Legal address:

Pfizer PGM, 5, avenue de Concyr, 45071, Orleans Cedex 2, France Pfizer PGM, France, Orleans, 45071, avenue de Concyr, 5.

Representative office in Russia:

Moscow representative office of Pfizer International LLC, 109147, Moscow, st. Taganskaya, 21.

Hexoral aerosol - video

In this article you can read the instructions for use of the drug Hexoral. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Hexoral in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Hexoral in the presence of existing structural analogues. Use for the treatment of sore throat, pharyngitis and gingivitis in adults, children, as well as during pregnancy and lactation.

Hexoral- an antiseptic drug for local use in ENT practice and dentistry. The antimicrobial effect of the drug is associated with the suppression of oxidative reactions of bacterial metabolism (thiamine antagonist).

The drug has a wide spectrum of antibacterial action (including against gram-positive bacteria) and antifungal action (including against fungi of the genus Candida).

Hexoral may also have an effect in the treatment of infections caused by Pseudomonas aeruginosa or Proteus.

At a concentration of 100 mg/ml, the drug inhibits most strains of bacteria. No development of resistance was observed.

Hexetidine (the active ingredient of the drug Hexoral) has a weak anesthetic effect on the mucous membrane.

Compound

Hexethidine + excipients.

Chlorhexidine dihydrochloride + benzocaine + excipients (Hexoral Tabs tablets).

Pharmacokinetics

Hexoral adheres very well to the mucous membrane and is practically not absorbed.

After a single use, the active substance is detected on the mucous membrane of the gums for 65 hours. In plaques on the teeth, active concentrations remain for 10-14 hours after application.

Indications

• inflammatory and infectious diseases of the oral cavity and pharynx;
• in the complex treatment of severe febrile or purulent diseases of the oral cavity and pharynx, requiring the use of antibiotics and sulfonamides, tonsillitis;
• tonsillitis (including tonsillitis with damage to the lateral ridges, Plaut-Vincent tonsillitis);
• pharyngitis;
• gingivitis and bleeding gums;
• periodontopathies, periodontal diseases and their symptoms;
• stomatitis, glossitis, aphthous ulcers to prevent superinfections;
• infection of the alveoli after tooth extraction;
• fungal infections of the oral cavity and pharynx, especially candidal stomatitis;
• before and after operations in the oral cavity and pharynx;
• additional oral hygiene for general diseases;
• elimination of bad breath, especially in the case of decaying tumors of the oral cavity and pharynx;
• an aid in the treatment of colds.

Release forms

Aerosol for topical use 0.2% (sometimes mistakenly called a spray).

Solution for topical use 0.1%.

Lozenges Geksoral tabs.

Instructions for use and method of use

The drug is applied topically.

When using an aerosol for topical use in adults and children over 3 years of age, a single dose is administered over 1-2 seconds.

When using a solution for topical use, rinse the mouth and throat with 15 ml of undiluted solution for 30 seconds.

The drug is prescribed 2 times a day (preferably in the morning and evening), after meals. Safe with more frequent use. Hexethidine adheres to the mucous membrane and due to this gives a lasting effect. In this regard, the drug should be used after meals.

The duration of treatment is determined by the doctor.

Rules for using the drug

When using a topical aerosol, the drug is sprayed into the mouth or throat. Using an aerosol you can easily and quickly treat the affected areas. You need to do the following:

1. Place the aerosol tube into the corresponding hole in the upper part of the bottle, lightly pressing on it, and point the tip of the tube away from you.

2. Hold the aerosol tube and direct it to the affected area of ​​the mouth or pharynx.

3. During administration, the bottle should be kept in an upright position at all times.

4. Inject the required amount of the drug by pressing on the head for 1-2 s, do not breathe while administering the aerosol.

The topical solution can only be used to rinse the mouth and throat. The solution should not be swallowed. When rinsing, you should always use an undiluted solution. When treating diseases of the oral cavity, the solution can also be applied using a tampon.

Pills

The tablet should be slowly dissolved in the mouth until completely dissolved.

The drug should be started immediately after the first symptoms of the disease appear and continued for several days after the symptoms disappear.

Adults and children over 12 years of age are prescribed 1 tablet every 1-2 hours as needed, but not more than 8 tablets per day.

Children aged 4-12 years are prescribed up to 4 tablets per day.

Side effect

• hypersensitivity reactions to the drug;
• with prolonged use, taste disturbance may occur.

Contraindications

• children under 3 years of age;
• hypersensitivity to any of the components of the drug.

Use during pregnancy and breastfeeding

There is no data on any damaging effects of the drug Hexoral during pregnancy and lactation. However, before prescribing Hexoral to pregnant or lactating women, the doctor must carefully weigh the benefits and risks of treatment, given the lack of sufficient data on the penetration of the drug through the placental barrier and into breast milk.

special instructions

The drug Hexoral in the form of a solution for topical use can be used to rinse the mouth and throat only if the patient can spit out the solution after rinsing.

The drug Hexoral solution for topical use contains alcohol - ethanol 96% (4.33 g/100 ml of solution).

Use in pediatrics

Children can use the drug from an age when there is no danger of uncontrolled swallowing when using the solution and topical aerosol or when they do not resist a foreign object (applicator) in the mouth when using a topical aerosol and are able to hold their breath when the drug is injected.

Drug interactions

Benzocaine, due to the formation of its metabolite 4-aminobenzoic acid, reduces the antibacterial activity of sulfonamides and aminosalicylates.

Sucrose, polysorbate 80, insoluble salts of magnesium, zinc and calcium reduce the effect of chlorhexidine.

Analogues of the drug Hexoral

Structural analogues of the active substance:

• Maxisprey;
• Stomatidin;
• Stopangin.

If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.

The remedy Hexoral became a three-time winner of the National Award “Product of the Year” in the “Remedy for Sore Throat” category!

The development of the drug was based on a study of the chemical compound hexethidine. Hexethidine has strong antiseptic properties, which manifest themselves in a decrease in the oxidative reactions of the metabolism of microorganisms (the opposite effect of the vitamin thiamine).

This discovery allowed the drug to be widely used against gram-positive bacteria and fungi of the genus Candida.

In further developments, it was revealed that the highly concentrated composition of the substance, when it comes into contact with the mucous surface, acts on most strains of bacteria, does not cause resistance of microorganisms to the drug and is not absorbed into the body’s circulatory system.

Thanks to these properties, hexetidine is widely used in medicine and has become the main component of the drug Hexoral. Reviews of the use of the remedy can be found at the end of the article.

Geksoral local antiseptic for external use, characterized by antimicrobial and antifungal properties. Additional effects of the drug are analgesic (pain reliever), hemostatic (hemostatic), enveloping and deodorizing.

Shows high activity against many types of bacteria, negatively affecting the cell membrane and inhibiting oxidative metabolic reactions. The drug is effective in the treatment of fungal infections, destroying membrane compounds, leading to their death. These are fungi of the genus Candida and Proteus.

In addition to the main component hexetidine, depending on the method of use of the drug, the medicine may contain eucalyptus and anise oils, peppermint oil, and 96% alcohol.

Eucalyptus oil is characterized by an antiseptic and analgesic effect. Anise oil has an anti-inflammatory and softening effect. Peppermint oil has bactericidal, antispasmodic and deodorizing properties. Ethanol is a powerful astringent antiseptic.

Instructions for use

Hexoral is produced in the form of an aerosol and solution, the latest development is absorbable tablets. Used in ENT therapy and dentistry.

Aerosol and solution are used:

• during an inflammatory process in the mouth and throat (tonsillitis, pharyngitis, ulcerative and aphthous stomatitis, glossitis, gingivitis, periodontal disease);
• for fungal infections of the mouth and throat (candidiasis);
• as an additional therapy for colds;
• to reduce bleeding gums;
• disinfectant and mouth freshener.

Hexoral tablets used for resorption when the first signs of acute respiratory viral infection appear, associated with painful sensations in the throat.

Aerosol Hexoral- a can of clear liquid with a menthol aroma.

Compound: hexethidine 200 mg, eucalyptus oil, alcohol 96%, glycerin, nitrogen, citric acid monohydrate, sodium saccharin, levomenthol, polysorbate 80, sodium hydroxide, water.

Mode of application: remove the cap from the can, put on the sprayer, insert the free end of the nozzle into the oral cavity. Keep the can vertical! Spray for 2 seconds while holding your breath. Remove the sprayer, rinse in water, and put on the cap.

For adults and children over 3 years of age, irrigate the mouth evenly 2 times a day approximately every 12 hours. The drug is used after eating. Settled on the mucous surface, it interacts with it, which leads to a long-lasting therapeutic effect. Use until recovery.

Hexoral solution- a reddish liquid product with a characteristic mint smell for external rinsing. Designed for rinsing the mouth and throat.

Compound: hexethidine 100 ml, ethanol (4.33 g alcohol per 100 ml solution), polysorbate 60, peppermint oil, anise, eucalyptus oil, clove oil, levomenthol, citric acid monohydrate, sodium saccharin, methyl salicylate, azorubine 85%, water.

Directions for use: in adults and children over 3 years of age use 15 ml of undiluted product. The duration of rinsing procedures is more than 30 seconds. Used medicine must be spat out!

Therapy is carried out in patients who are able to spit out fluid. Instead of rinsing, the drug can be applied to the inflamed areas using a swab dipped in the solution. Apply 2 times a day in the morning and evening, after meals. The duration of therapy is prescribed by the doctor.

Hexoral tablets designed to reduce local inflammation and soreness in the throat.

Composition of the tablet: chlorhexidine dihydrochloride - 5 mg, benzocaine - 1.5 mg, peppermint oil, menthol, aspartame, isomalt, water.

Mode of application: in the first days of a cold, accompanied by a sore throat. For adults and children over 12 years of age, dissolve 1 tablet every 2 hours until completely dissolved, but not more than 8 tablets per day. Children from 4 to 12 years old take no more than 4 tablets per day. Treatment of children under 12 years of age is carried out only after consultation with a doctor.

Interaction with other drugs

Not researched.

Side effects

Treatment with Hexoral can cause allergies and changes in taste.

Contraindications:

• presence of hypersensitivity to components;
• age up to 3 years (allowed only if the child does not resist the introduction of the spray, is able to hold his breath, and also spits out the used solution);
• age up to 12 years with tablet therapy;
• There are no contraindications during pregnancy and breastfeeding, but consultation with a doctor is required;
• Due to the 96% alcohol content in the medicinal liquid of the aerosol and solution, use with caution by persons driving a vehicle.

Overdose

Hexoral has no toxicity if you follow the doses recommended in the instructions.

Ingestion of the solution can provoke vomiting and cause acute alcohol poisoning (if large doses are swallowed). In this case, you need to rinse your stomach and consult a doctor.

Storage

Store for 2 years, in a dark place, out of reach of children, no higher than 25 degrees.

Price

The cost of Hexoral depends on the type of medicine produced. So in Russia Hexoral costs:

• aerosol from 159.00 to 210.00 rubles;
• solution 148.00 - 256 rubles;
• tablets about 120.00 rub.

In Ukraine price:

• an aerosol costs about 189.00 UAH;
• solution 210.00 - 256.00 UAH;
• tablets from 19.00 to 25.00 UAH.

All medications are available without a prescription.

Analogues

Hexetidine, Hexoral tabs classic, Maxicold Lor, Maxisprey, Stomatidin,

Hexoral in the form of a spray receives good reviews from patients susceptible to inflammatory throat diseases. Being an effective remedy against bacterial and fungal infections, it is safe and can be used by those categories of patients for whom many drugs are contraindicated.

Instructions for use of the Hexoral aerosol recommend the product for use by pregnant women, as well as children of any age.

In contact with

Classmates

Instructions for use of Hexoral spray

Hexoral belongs to non-dosed spray aerosols. When you press the release nozzle, the product is sprayed not once, but as long as you press. Instructions for use of Hexoral spray advise spraying the product for 1-2 seconds.

Instructions for adults

Spray the product while sitting or standing with the head in a vertical position.

Follow the following instructions:

1. Place the spray nozzle on the bottle.
2. Hold the bottle vertically: bottom down, nozzle up.
3. Insert the spray tip into your mouth and aim it at the back of your throat.
4. Inhale and hold your breath.
5. Press and hold the release nozzle for 1-2 seconds.
6. Exhale and continue breathing.

Aerosol Hexoral, settling on the mucous membrane of the throat, remains on it for up to 12 hours. Instructions for use of Hexoral aerosol recommend using it twice a day: morning and evening - both times after meals. For the medication to work more effectively, you should avoid eating or drinking for as long as possible after spraying.

Hexoral spray for children

The product is recommended for children from 3 years of age. As noted in the instructions for use of Hexoral spray, the age limit is associated with two factors:

• The child must be able to hold his breath;
• The child should calmly accept the introduction of the spray nozzle into the mouth.

Thus, if the child understands the meaning of the procedure and does not resist it, then the spray can be used by children under 3 years of age.

Instructions for use of Hexoral spray for children:

1. If possible, explain to your child the meaning of the procedure. Explain that you will need to hold your breath. Practice: for example, on the count of “one” the child holds his breath, on the count of “four” he exhales. Children copy the actions of adults well: it will be a good help if the adult performing the procedure takes a deep breath and holds his breath so that the child can see how this is done.
2. Ask your child to open his mouth. Please note that the root of the tongue should not block access to the throat, i.e. The child must breathe through his mouth before holding his breath.
3. Hold the bottle vertically with the nozzle facing up.
4. Carefully insert the spray nozzle into your mouth shallowly: the pressure in the balloon is enough to spray the medicine 5-8 cm.
5. Give the command to hold your breath.
6. After making sure that the breath is held, press the release nozzle and hold for 1 second.
7. Remove the mouthpiece from your mouth.

Hexoral has a menthol flavor. Not all children perceive the use of aerosol positively. Moreover, after spraying, you must refrain from eating and drinking for at least 1-2 hours. Prepare a toy in advance to distract your child from possible unpleasant sensations.

During pregnancy

After spraying, Hexoral remains on the mucous membrane, practically not penetrating into the bloodstream. In studies conducted on the safety of the drug, no undesirable effects on the fetus were identified. However, no studies have been conducted on the penetration of hexethidine through the placenta, and conclusions about the safety of the drug for pregnant women are made solely on the basis of the fact that the substance, if it penetrates the systemic bloodstream, does so in microscopic quantities.

Instructions for use of Hexoral spray advise discussing the advisability of using the drug in the 1st trimester of pregnancy with your doctor.

Hexoral during pregnancy in the 2nd trimester and 3rd trimester is considered the safest of all antiseptic drugs for the treatment of bacterial and fungal throat infections. However, this does not obviate the need to consult a doctor.

Hexoral during lactation

There are no data on the penetration of hecatidine into breast milk. The theoretical probability of such penetration is extremely low: the drug acts locally and is not absorbed. The use of Hexoral during lactation is considered safe.

Composition and properties of the spray

The antiseptic and antifungal effect of Hexoral is due to its constituent hecatidine (0.2%). This chemical disrupts metabolic processes in bacteria and fungi, damages their outer shell, which together leads to their death.

Medical alcohol (4.3%) has an additional antiseptic effect.

Levomenthol has a slight anesthetic effect.

As excipients, Hexoral spray also contains:

• Citric acid;
• eucalyptus oil;
• sweetener;
• preservative

The spray is available in a volume of 40 ml.

Indications for use

Hexoral spray is indicated for inflammatory diseases of the throat that have a bacterial and/or fungal cause.

Levomenthol, which is part of the drug, reduces the sensitivity of the throat mucosa, thereby reducing soreness and pain. Since during self-treatment the cause of pain is not clear - it can be either viral or bacterial - it is advisable to use Hexoral spray in combination with immunomodulating agents (Ingavirin, Ergoferon, Grippferon, etc.).

Use Hexoral spray for colds in accordance with the instructions if respiratory symptoms appear - cough, tickling, accompanied by malaise, fever. Spray twice daily for as long as painful symptoms persist, but not for more than 7 days. Remember that if the condition does not improve by day 3, you should seek qualified medical help to conduct additional tests and prescribe appropriate antibiotics.

Always has a bacterial cause. The most common pathogen is usually sensitive to hexethidine. A convenient spray nozzle allows you to spray the medicine directly onto the inflamed tonsils.

At the same time, it should be borne in mind that a local antiseptic is an additional remedy in the treatment of sore throat. To suppress the development of infection, antibiotics are required.

Hexoral spray is indicated for the treatment of bacterial or fungal pharyngitis. However, due to the fact that in most cases pharyngitis begins as a viral disease, immunomodulatory therapy aimed at preventing the replication of viruses is of paramount importance.

If treatment is started correctly in adults, Hexoral spray may not be required at all, because A bacterial or fungal complication does not always accompany viral pharyngitis.

For pharyngitis in children, Hexoral is indicated from the first day of the disease, because bacterial infection in childhood develops rapidly. There will be no harm from the preventive use of Hexoral. At the same time, it will minimize the consequences of the viral disease.

Other types of Hexoral

Hexoral tablets

By analogy with Hexoral spray, the tablets contain several components that act in two directions:

• Antibacterial;
• anesthetic.

Hexoral tablets contain benzocaine (Tabs) or lidocaine (Tabs Classic and Tabs Extra) as an anesthetic. The analgesic effect of tablets is more noticeable than that of a spray.

Hexoral tablets are taken by dissolving them in the mouth. They are contraindicated in children.

The purpose of Hexoral solution is to treat bacterial and fungal infections of the oral cavity by rinsing. The gargling procedure is ineffective for sore throats, or at least less effective than a fine spray.

Side effects and contraindications

Hexoral acts locally. Does not penetrate tissue. Absorption into the systemic circulation is minimal. Possible side effects include a local irritation reaction in the form of redness of the mucous membrane, soreness or itching.

In this regard, it is contraindicated in case of individual sensitivity to the components of the drug.

The spray should not be used by children who cannot control their breathing. Contact of the mucous membrane of the child’s lower respiratory tract with fine particles of the drug can provoke a serious condition - spasm of the larynx and/or trachea.

As a result of laryngospasm, the child's breathing becomes difficult and may stop completely.

List of drug analogues

In pharmacies you can find several drugs similar in action to Hexoral. Of these, two of them are direct analogues in composition.

Analogues are cheaper

You can save from 40% to 70% percent if you use one of the following drugs instead of Hexoral:

• Kameton;

Maxicold Lor, a Russian-made spray, is the closest analogue of Hexoral. It contains hexetidine and other substances (levomentone, medical alcohol, plant extracts) in concentrations similar or approximately equal to Hexoral. It is used in the same way. In the instructions for use, the manufacturer does not recommend using Maxicold Lor for children under 8 years of age.

– a product of the domestic pharmaceutical industry, produced for more than 50 years. The antiseptic effect is due to chlorobutalone and eucalyptus oil. The composition also contains anesthetic substances: levomenthol, camphor.

Miramistin differs from the drugs discussed above in the absence of taste and smell. For people who cannot tolerate menthol and camphor, Miramistin is a good alternative as an adjuvant for the treatment of pharyngitis and sore throat. It is not sprayed finely, so there is no risk of respiratory tract spasms in children. The only disadvantage of Miramistin is that the drug is sold in a large-capacity bottle of 150 ml, the price of which is higher than Hexoral 40 ml. However, if we compare the same volumes, then the cost of Miramistin is 3 times lower than Hexoral (i.e. savings - 70%).

Analogs are more expensive

In pharmacies you can find sprays that are in a higher price category. These include:

• Stopangin;
• Novosept forte spray.

– a Czech-made drug – is the second direct analogue of Hexoral in composition. Available in 30 ml bottles. With a similar regimen, the cost of treatment with Stopangin will be 20% more expensive.

Novosept is produced by a Dutch pharmaceutical company. It is not analogous to Hexoral in composition, but also has an antiseptic and analgesic effect. Among other things, it contains zinc sulfate, which stimulates local mucosal immunity. The price of a 25 ml bottle is comparable to the cost of Hexoral. However, Novosept needs to be used every 2 hours (5-6 times a day), which is why the cost of treatment increases significantly. In addition, the drug is contraindicated during pregnancy and lactation.

The effectiveness of Hexoral spray: user review.

Conclusion

The spray is indicated for children from 3 years of age or earlier, if the child calmly tolerates aerosol spraying and can hold his breath. Hexoral can be used during pregnancy, with the exception of the 1st trimester, during which you should abstain from the drug or, at least, discuss the issue with your doctor.

Patients using Hexoral without a doctor's prescription should keep in mind that this drug must be used in combination with other medications: antivirals, immunomodulators, antibiotics.

A cheaper analogue of Hexoral is Maxicold Lor spray. Its price is on average 40% lower.

In contact with

Name:

Hexoral

Pharmacological
action:

Antiseptic.
The antimicrobial effect of the drug Hexoral is associated with the suppression of oxidative reactions of bacterial metabolism (thiamine antagonist).
The drug has a wide spectrum of antibacterial and antifungal action, in particular against gram-positive bacteria and fungi of the genus Candida, however Hexoral can also have an effect in the treatment of infections caused, for example, by Pseudomonas aeruginosa or Proteus.
At a concentration of 100 mg/ml the drug suppresses most strains of bacteria. No development of resistance was observed.
Hexethidine has a weak anesthetic effect on the mucous membrane.
Pharmacokinetics
Hexethidine adheres very well to the mucous membrane and is practically not absorbed.
After a single use of the drug, traces of the active substance are found on the gum mucosa for 65 hours.
In plaques on teeth, active concentrations remain for 10-14 hours after application.

Indications for
application:

Inflammatory and infectious diseases of the oral cavity and pharynx;
- in complex treatment of severe febrile or purulent
diseases of the oral cavity and pharynx requiring prescription
antibiotics and sulfonamides, tonsillitis;
- tonsillitis (including tonsillitis with damage to the lateral ridges, tonsillitis
Plaut-Vincent);
- pharyngitis;
- gingivitis and bleeding gums;
- periodontopathies (periodontal diseases and their symptoms);
- stomatitis (inflammation of the oral mucosa), glossitis
(inflammation of the tongue), aphthous ulcers (painful inflammation with
surface tissue defects) for the purpose of prevention
superinfections;
- infection of the alveoli (tooth sockets) after tooth extraction;
- fungal infections of the oral cavity and pharynx, especially candidal stomatitis (thrush);
- before and after operations in the oral cavity and pharynx;
- additional oral hygiene for general diseases;
- elimination of bad breath, especially in the case of
collapsing tumors of the oral cavity and pharynx;
- an aid in the treatment of colds.

Mode of application:

Hexoral is a remedy for topical use in the oral cavity.
Spray
Adults and children over 6 years of age.
Procedure technique:
- install the flexible tube into the corresponding hole on the head of the bottle, pressing lightly on it. Point the end of the flexible tube away from you;
- holding the flexible tube in your mouth, direct it to the appropriate area of ​​the mouth or throat. During the procedure, always keep the bottle upright;
- holding your breath, inject Hexoral spray by pressing the head of the balloon for 1–2 s.

Apply 2 times a day, preferably in the morning and evening, after meals.
The duration of treatment is determined by the doctor depending on the severity and characteristics of the disease.

Solution
Adults, elderly people, teenagers and children over 6 years of age.
You should rinse your mouth or gargle with 15 ml of undiluted solution for 30 seconds 2 or 3 times a day.
Do not swallow the drug.
For rinsing, use undiluted solution.
The duration of treatment is determined by the doctor depending on the severity and characteristics of the disease.

Side effects:

- from the skin and subcutaneous tissue: the occurrence of ulcers on the mucous membrane, allergic contact dermatitis, angioedema;
- general disorders: change in taste sensations over 48 hours (the feeling of “sweet” can change twice to the feeling of “bitter”); sensitivity of the mucous membrane, namely burning, numbness; irritation (pain, sensation of heat, itching) of the tongue and/or oral mucosa, decreased sensitivity; hypersensitivity;
- other adverse reactions: reversible change in the color of teeth and tongue; Azorubine may cause allergic reactions;
- in case of accidental ingestion The drug may cause gastrointestinal disturbances, primarily nausea and vomiting.

Contraindications:

Hexoral spray:
- age up to 6 years;
- the spray is contraindicated in patients with asthma or any other respiratory tract diseases associated with their hypersensitivity. Inhalation may cause bronchoconstriction.

Hexoral solution:
- hypersensitivity to hexetidine, azorubine, eucalyptus oil, levomenthol, peppermint oil or any other component of the drug;
- age up to 6 years.

There are no special instructions.
Hexoral solution for topical use can be used to rinse the mouth and throat only if the patient can spit out the solution after rinsing.
Hexoral solution for topical use contains ethanol 96% (4.33 g/100 ml solution).

Use in pediatrics
In children, the drug can be used from an age when there is no danger of uncontrolled swallowing when using the solution.

The ability to influence reaction speed when driving vehicles or other mechanisms.
Hexoral does not affect the ability to drive or operate other machinery.

Interaction
other medicinal
by other means:

Pregnancy:

There is no data on the negative impact of Hexoral on the body of the fetus (child) or pregnant woman (nursing mother), however, due to insufficient data on the possibility of penetration of the drug components into breast milk or through the placental barrier, the use of the drug during lactation and pregnancy is possible only after a thorough analysis of the relationship between potential harm to the fetus and benefit to the mother.

Overdose:

Hexetidine in the indicated dosage is non-toxic.
Symptoms: Ingestion of large quantities of the drug results in vomiting, so significant absorption is not expected.
No cases of alcohol poisoning due to overdose have been described.
Acute alcohol poisoning is very unlikely, but theoretically possible if a large dose of the drug is swallowed by a small child.
Treatment: Gastric lavage is necessary within 2 hours after ingestion of an excess dose.
Carrying out symptomatic therapy, as for alcohol intoxication.
In any case of overdose, the patient should immediately consult a doctor.

Release form:

Hexoral solution 0.1% in 100 ml bottles.
Hexoral aerosol 0.2% in a 40 ml aerosol can.

Storage conditions:

The drug should be stored out of the reach of children at a temperature not exceeding 25°C.
Best before date- 2 years.
The drug is approved for use as a means of OTC.

Spray for mouth. cavities 0.2% contains:
- active ingredient: hexetidine 2 mg/ml;
- excipients: sodium saccharin, citric acid monohydrate, sodium hydroxide, glycerin, macrogol lauryl ether, mint flavor, purified water, nitrogen.

R-r d/rotov. cavities 0.1% fl. 200 ml contains:
- active ingredient: hexetidine 1 mg/ml;
- excipients: polysorbate 60, sodium saccharin, citric acid monohydrate, methyl salicylate, azorubine (E122), levomenthol, peppermint oil, anise oil, eucalyptus oil, clove oil, ethanol 96%, purified water.