Phlebodia drug. Phlebodia - instructions for use. There are also auxiliary components

The basis and active ingredient of Phlebodia 600 is purified anhydrous diosmin. It is contained in an amount of 600 mg in granular form.

There are also auxiliary components:

• stearic acid;
• microcrystalline cellulose (contained in the shell);
• colloidal silicon dioxide;
• talc.

The composition of phlebodia includes a shell made of such substances:

• iron oxide red and black;
• titanium dioxide;
• red conichel;
• macrogol stearate;
• wax carnauba (palm) and bees;
• shellac;
• hypromellose;
• polyethylene glycol stearate.

The active substance of the drug acts mainly on the state of the venous bed:

• reduces stretch;
• increases tone;
• strengthens capillaries and prevents their damage;
• indirectly reduces congestion in the veins;
• increases lymphatic drainage;
• reduces the permeability of the walls of venous vessels.

The effect of increasing the tone in direct proportion depends on the amount of the drug taken (dose-dependence). Thanks to Phlebodia, there is an improvement in the blood supply to peripheral tissues and skin.

In recent studies, it has been proven that the drug can act on biologically active substances, activating the action of adrenaline and norepinephrine when they narrow the lumen of the vessels. It also reduces the flow of white blood cells to the veins and prevents the formation of free radicals. This is how its anti-inflammatory effect is manifested.

Phlebodia 600 is available in the form of tablets convex on both sides, with a special protective shell on top. There are 15 pieces in a blister. This form was adopted by the manufacturer and is still preserved.

The active substance of this drug is an angioprotector, and is intended to strengthen blood vessels. Diomin belongs to flavonoids, it improves microcirculation, and thus optimizes local metabolic processes.

The drug is taken orally and is rapidly absorbed, after about two hours half the dose is determined in the blood, and the maximum concentration is reached after five hours. Redistribution in the body is carried out 9 hours after ingestion. It occurs in such a way that the main part of diosmin falls on the inferior vena cava and venous vessels of the extremities. Final elimination occurs after 96 hours.

Indications and contraindications

What does this medicine help with? The main indications for the use of Phlebodia 600 are the main abilities of diosmin to improve blood flow in the veins and capillary network:

• chronic venous insufficiency;
• prevention of orthostatic hypotension and collapse after surgery;
• prevention of bleeding after;

According to some experts, the drug may prevent the development of hemorrhagic disorders during the use of the intrauterine device. Phlebodia's compatibility with other drugs is good.

There are also contraindications to the use of the active substance:

• age under 18;
• breast-feeding (no studies on penetration into breast milk);
• first trimester of pregnancy;
• individual intolerance to the active substance and other components (very rare).

Side effects

When using the drug Phlebodia 600, side effects are usually noted only in exceptional cases. Most patients tolerate it satisfactorily, but sometimes it is noted:

• digestive disorders (nausea, vomiting, diarrhea);
• headache.

If such signs appear, you should stop taking the remedy and consult your doctor about reviewing the treatment. Usually, the undesirable effect disappears immediately after the cessation of use, and special methods for removing the substance from the body are not required.

Alcohol combined with diosmin can produce unexpected results. With their compatibility, ulcers appear on the gastric mucosa, and the risk of internal bleeding increases. Therefore, for the duration of treatment to prevent unwanted reactions, the use of alcoholic beverages is not recommended.

How to use

Venous insufficiency

How to take Phlebodia 600 for varicose veins? In case of blood stagnation and the development of venous insufficiency, Phlebodia 600 is usually recommended to drink as an addition to the complex treatment of pathology.

Diosmin helps slow down the rate of progression of the pathology, prevents the development of complications, reduces discomfort (pain, heaviness, discomfort). It also reduces the severity of edematous syndrome, and therefore improves the patient's quality of life. The drug is taken once, on an empty stomach in the morning.

The duration of use depends on the severity of the process:

• with uncomplicated variants of the disease, the reception continues for 60 days;
• when the patient has convulsions and dry skin from time to time, Phlebodia 600 is taken for 3-4 months;
• the appearance is an indication for a longer use (up to six months).

After completing the full course, you need to take a break (at least 4 months), after which treatment can be continued if necessary. For the prevention of varicose veins, it is enough to take one tablet per day for 1-2 months.

Exacerbation of hemorrhoids

Phlebodia 600 with hemorrhoids relieves the manifestations of inflammation and blood stasis in the nodes. This helps relieve tension and discomfort. In this case, you should take 2-3 tablets during the day, along with your usual food. The general course of treatment during the acute process is one week. The convenience of using tablets in this disease is that their use is possible in a public place and does not require privacy (unlike ointment or rectal suppositories).

When you drink this remedy for acute hemorrhoids, you should not use topical angioprotective ointments, as they are only intended for application to the skin. In order to treat bumps and cracks in the anus, you should buy special suppositories and creams.

Use of the drug in pregnant women

Is it possible to use this remedy for pregnant women? The doctor may prescribe the use of the drug during the period of gestation in the presence of chronic lymphatic and venous insufficiency. The remedy is not recommended to be taken in the first trimester, when the laying of the organs and systems of the fetus occurs, at a later date no negative effects on the fetus were found.

Phlebodia 600 during pregnancy is used for a long time, 1 tablet per day. Termination of therapy is carried out two weeks before the expected date of birth, so as not to provoke bleeding. Deterioration of the condition and side effects in this case, as a rule, is not observed. The drug has a positive effect on the blood circulation of the placenta, indirectly improving the development of the unborn baby.

Phlebodia or Troxevasin?

With problems of venous outflow, specialists in some cases may prescribe another venotonic - Troxevasin. What is the difference between him and Phlebodia, and what is better to take?

Indications for use for these drugs are the same and they are classified according to their classification into one group - venotonics. But their active ingredients are different. Given the individual characteristics of each human body, you need to understand that the reaction to a particular drug may be different. If the patient previously drank one remedy, then if undesirable effects appear, it can be easily replaced with another type of venotonic.

Troxevasin contains 300 mg of troxerutin, which is a glycoside. Diosmin is derived from hesperidin, a substance found in citrus fruits. Contraindications to the use of Troxevasin are almost the same, but it should not be taken with a tendency to gastrointestinal bleeding.

The final decision on the use of Troxevasin or Phlebodia remains with the doctor. In severe cases, they can be used simultaneously (it is especially effective to combine tablets and gel for external use).

The manufacturer of the drugs claims that Troxevasin can be taken from the age of 15, and Phlebodia 600 tablets are recommended only after 18. Both drugs are not prescribed in the first three months of pregnancy and during lactation.

Analogues

The full generics of Phlebodia 600 are Vasoket 600 and Diovenor 600. They have the same active ingredient composition. However, their manufacturer is different, and they are not so widespread. There are also Diosmin tablets, but the content of the active ingredient in them is somewhat less - 500 mg.

A very popular analogue of the drug Flebodia 600 is the drug Detralex. It includes 50 grams of hesperidin and 450 grams of diosmin. Due to this, the tool is highly effective in venous congestion. The medicine is prepared by a unique micronization method, and therefore the active substance is absorbed very quickly and without loss in the intestine. Since its excretion is carried out mainly through the gastrointestinal tract, it is chosen for the treatment of those patients who have problems with the functioning of the kidneys and heart muscle. The drug has exactly the same composition and effect.

With the development of stagnation of blood and lymph in the lower extremities and pelvis, you should go to a specialist and start treatment. To alleviate symptoms and improve the condition, you should stop smoking, normalize weight, lead an active lifestyle and take medicinal substances.

The basic rules for taking the venotonic agent Flebodia 600 are strict adherence to the dosage and doctor's prescriptions for its use. Most often, the drug is prescribed in conjunction with other drugs, and goes well with them without causing negative reactions. Separately from others, it can be used as a prophylaxis for varicose veins and hemorrhoids.

Useful video about Phlebodia 600

Phlebodia 600 is one that has a venotonic effect: it increases the tone of the veins, reduces their extensibility and reduces venous congestion. The drug improves lymphatic drainage, that is, increases the frequency of capillary contractions and their functional density, reduces lymphatic pressure.

Phlebodia 600 is also excellent for improving microcirculation, its systematic use can lead to a decrease in vascular permeability and an increase in their resistance. Phlebodia 600 has an anti-inflammatory effect and can block the production of free radicals.

Phlebodia refers to venotonics, which include. Excipients in the composition of the drug: colloidal silicon dioxide, talc, microcrystalline cellulose, stearic acid, a protective film such as Sepifilm 002, a mixture of dyes such as Sepisperse AP 5523 (these include hypromellose, propylene glycol, titanium dioxide, cochineal red (Ponso 4R), iron oxide red, iron oxide black), Opagloss 6000.

Indications for use

The properties of the drug allow you to use it:

• for the treatment and prevention, as well as chronic lymphovenous insufficiency of the lower extremities;
• for the treatment of microcirculation disorders and edematous syndrome during pregnancy.

Mode of application

If Phlebodia 600 is used to treat lymphovenous and if there are no complications, then the drug is taken 1 tablet once a day for 2 months. This course is recommended for mild varicose veins.

With moderate severity of the disease, the drug is taken 1 tablet daily, for 3 months. With a severe degree of varicose veins, including if they are formed, the drug is taken 1 tablet every day for six months.

The drug is also used for the treatment in pregnant women, which arose against the background of lymphovenous insufficiency. According to the instructions for use, in this case, appoint 1 tablet daily. Phlebodia must be canceled 2 to 3 weeks before the birth.

Pharmacokinetics

Phlebodia is rapidly absorbed from the gastrointestinal tract. In plasma, it is detected 2 hours after direct administration. The maximum concentration is reached 5 hours after ingestion. Phlebodia is evenly distributed and accumulates in all layers of the walls of the vena cava. The smallest amount of the drug accumulates in the liver, kidneys, lungs and other tissues. The main part of the drug - 79% - is excreted in the urine, of the remaining: 11% - with feces, and with bile - 2.4%.

Contraindications and side effects

Phlebodia is not used for hypersensitivity or individual intolerance to the components. The medicinal product may not be used by persons under the age of 18 years.

Side effects:

• headache;
• dyspepsia;
• allergic reactions associated with the presence of hypersensitivity to the components of the drug.

Phlebodia and pregnancy

It is noted that in clinical practice no side effects have been identified from the use of the drug in. Moreover, experimental studies have shown that the drug does not have a teratogenic effect on the fetus.

When breastfeeding, the drug, like a number of other venotonics, is not recommended, since it has not been studied whether it penetrates into breast milk and how it affects its composition.

Overdose of Phlebodia 600 and special instructions

Signs indicating an overdose are not described in clinical practice.

There are some special instructions. In the treatment of an acute attack of hemorrhoids, phlebodia is used in combination with other drugs. If a positive effect does not occur quickly, then an additional examination should be carried out and, based on its results, the prescribed treatment should be adjusted.

Despite the fact that the list of indications for the use of the drug was indicated above, in medical practice Phlebodia is also used for the treatment of fetoplacental insufficiency, during the period and for the prevention of bleeding resulting from the use of an intrauterine device.

Reviews about Flebodia 600

Advantages of the drug:

• no side effects with long-term use;
• the ability to use the drug as a prophylactic agent. Many women with a predisposition to varicose veins noted that after taking the drug they felt light in their legs, leg fatigue disappeared;
• the disappearance of small ones;
• reasonable price - 30 tablets cost an average of $20. Since only one tablet needs to be taken per day during treatment, a monthly course is inexpensive;
• thanks to the use of Phlebodia in the complex treatment of hemorrhoids, it was possible to avoid surgery.

Disadvantages of the drug:

• large tablet size. This disadvantage can be easily overcome by dividing the tablet into two parts;
• the presence of dyes in the preparation. It should be noted that this statement is true.

Flebodia 600 analogues

Phlebodia 600: instructions for use and reviews

Phlebodia 600 (active ingredient - diosmin) - the original venoprotector from the French pharmaceutical company "Laboratory Innotec International". The drug has a venotonic effect (increases their tone in a dose-dependent manner, reduces extensibility, prevents venous congestion), accelerates the outflow of lymph, thereby ensuring the implementation of the drainage function (tones and increases the frequency of contraction of the muscular membrane of the lymphatic capillaries, increases their functional activity, reduces pressure in the lymphatic channel) , stimulates blood flow in the capillary bed (dose-dependently increases vascular resistance, reduces the permeability of capillary walls), prevents leukocytes from sticking to the walls of the veins and inhibits their movement into paravenous tissues, improves the diffusion of molecular oxygen and promotes oxygenation of the skin tissue. In addition to this, Phlebodia 600 exhibits an anti-inflammatory effect, enhances the vasoconstrictor effect of catecholamines, blocks the reproduction of free radicals, the synthesis of inflammatory mediators and allergic reactions of prostaglandins and thromboxane. The drug is rapidly absorbed in the gastrointestinal tract and enters the systemic circulation in therapeutically significant concentrations within 2 hours after administration. The maximum concentration of the active substance in the blood plasma is observed 5 hours after ingestion. The drug is evenly distributed and accumulated in the thickness of the walls of the vena cava and superficial veins of the legs, and, to a lesser extent, in the internal organs (kidneys, liver, lungs). The accumulation of Phlebodia 600 and its metabolites in the vessels of the venous bed reaches its highest rate at 9 hours after oral administration and persists for 4 days. The main part of the drug is excreted by the kidneys, the remaining amount - through the intestines.

Phlebodia 600 is available in the form of tablets. Before starting a medication course, you should consult with a specialist. In case of varicose veins with the localization of the pathological process in the veins of the lower extremities, as well as with swelling, pain and convulsions, which are the result of chronic lymphovenous insufficiency, the drug is taken on an empty stomach, 1 tablet per day.

The duration of treatment is usually 2 months. In acute hemorrhoids (or exacerbation of chronic) Phlebodia 600 take 2-3 tablets per day with meals for 1 week. If, for some reason, the drug is missed, it is not necessary to compensate for the missed doses by taking additional doses (pharmacotherapy continues as usual at the same doses). Treatment of acute hemorrhoids should be complex (in other words, not based on one drug). If the clinical effect is not sufficiently pronounced, the patient should be referred for additional examination and adjustments to the treatment should be made.

The effectiveness of Phlebodia 600 has been demonstrated in a number of clinical studies, the largest of which involved about 7,000 patients. In this study, participants took 1 tablet of the drug per day (in acute cases - 2 tablets). Patients were subjected to a medical examination before and at the end of the first month of treatment. In general, the observation lasted for 2 months. Study participants were instructed to forego other phlebotonics and to avoid significant adjustments to their lifestyle and routine habits (including food preferences and physical activity levels). The results obtained at the end of the clinical trial made it possible to state the high therapeutic efficacy of Phlebodia 600 and to determine the optimal ways of using the drug. The drug showed itself from the best side, surpassing its competitors in the pharmacological "niche". So, when using Phlebodia 600, more than 80% of positive outcomes were obtained, while for other venotonics this figure did not exceed 40%. The dependence of the effectiveness of therapy on its duration was noted. So, the good results obtained by the end of the first month of the drug course, provided that the drug is continued, are transformed into excellent ones.

Pharmacology

The drug has a phlebotonizing effect (reduces vein extensibility, increases vein tone (dose-dependent effect), reduces venous congestion), improves lymphatic drainage (increases the tone and frequency of contraction of lymphatic capillaries, increases their functional density, reduces lymphatic pressure), improves microcirculation (increases the resistance of capillaries (dose-dependent effect), reduces their permeability), reduces the adhesion of leukocytes to the venous wall and their migration to paravenous tissues, improves oxygen diffusion and perfusion in the skin tissue, and has an anti-inflammatory effect. Enhances the vasoconstrictive action of adrenaline, norepinephrine, blocks the production of free radicals, the synthesis of prostaglandins and thromboxane.

Pharmacokinetics

Rapidly absorbed from the gastrointestinal tract, found in plasma 2 hours after ingestion. C max in blood plasma is achieved 5 hours after ingestion. It is evenly distributed and accumulated in all layers of the wall of the vena cava and saphenous veins of the lower extremities, to a lesser extent - in the kidneys, liver and lungs and other tissues.

The selective accumulation of diosmin and / or its metabolites in the venous vessels reaches a maximum by 9 hours after ingestion and persists for 96 hours. Excreted by the kidneys - 79%, intestines - 11%, with bile - 2.4%.

Release form

Pink, film-coated tablets, round, biconvex.

Excipients: talc - 10.24 mg, colloidal silicon dioxide - 3.5 mg, stearic acid - 50.05 mg, microcrystalline cellulose - up to 910 mg.

The composition of the film shell: Sepifilm ® 002 (hypromellose (E 464) - 9.832 mg, microcrystalline cellulose - 7.866 mg, macrogol 8 stearate type 1 - 1.967 mg); Sepispers ® AP 5523 pink (propylene glycol - traces, hypromellose (E 464) - 0.458 mg, titanium dioxide (E 171) - 4.026 mg, crimson dye [Ponso 4R] (E 124) - 0.401 mg, iron oxide black (E 172) - 0.13 mg, iron oxide red (E 172) - 0.02 mg); Opagloss ® 6000 (Carnauba wax (E 903) - 0.075 mg, beeswax (E 901) - 0.075 mg, shellac (E 904) - 0.15 mg, ethanol 95 ° - traces).

15 pcs. - Al/PVC blisters (1) - cardboard packs.
15 pcs. - Al/PVC blisters (2) - cardboard packs.

Dosage

Before using the drug, you should consult your doctor. The drug is intended for oral administration.

With varicose veins of the lower extremities and chronic lymphovenous insufficiency (edema, pain, convulsions), 1 tab. / day is prescribed. on an empty stomach in the morning. The duration of therapy is usually 2 months.

With exacerbation of hemorrhoids, the drug is prescribed 2-3 tablets / day. during meals for 7 days.

If one or more doses of the drug are missed, it is necessary to continue using the drug as usual and at the usual dose.

Overdose

Overdose symptoms are not described.

Interaction

Clinically significant interaction effects with other drugs have not been described.

Side effects

In rare cases, hypersensitivity to the components of the drug, requiring a break in treatment: on the part of the gastrointestinal tract - dyspeptic disorders (heartburn, nausea, abdominal pain), on the part of the central nervous system - headache.

If any of the side effects listed in the instructions get worse, or you notice any other side effects not listed in the instructions, tell your doctor.

Application features

Use during pregnancy and lactation

So far, in clinical practice, there have been no reports of any side effects when using the drug in pregnant women. Application during pregnancy in the II and III trimesters is possible only on prescription in cases where the expected benefit to the mother outweighs the potential risk to the fetus.

In experimental studies, no teratogenic effects on the fetus have been identified. During breastfeeding, the drug is not recommended, because. there is no data on the penetration of the drug into breast milk.

Use in children

special instructions

Treatment of an acute attack of hemorrhoids is carried out in combination with other drugs, in the absence of a rapid clinical effect, it is necessary to conduct an additional examination and adjust the ongoing therapy.

Influence on the ability to drive vehicles and control mechanisms

There is no evidence of a negative effect of the drug on the ability to drive vehicles and other mechanisms.

Phlebodia 600 is a drug that helps fight varicose veins in the legs. Phlebodia belongs to the group of angioprotective drugs. This means that the action of this drug is aimed at protecting and restoring already weakened veins that have lost their tone.

The venotonic effect of the drug is caused by its constituent - diosmin. This is an active substance that has a direct effect on the human body as a whole.

The drug Phlebodia 600 has many analogues in its main component, but they all differ in many additional (auxiliary) substances. The manufacturer of this drug is the French laboratory INNOTHERA CHOUZY.

Release form and composition

Phlebodia 600 is available in tablet form. Tablets are convex, round, 15 pieces in a blister. Usually a pack contains 1 or 2 blisters, that is, a package contains 15 or 30 tablets.

The composition includes the active substance diosmin. The dosage of diosmin is 600 mg. Among the excipients, microcrystalline cellulose at a dosage of 910 mg, stearic acid - 50.05 mg, colloidal silicon dioxide - 3.5 mg and talc - 10.24 mg can be distinguished.

Indications for use

Instructions for use shows this drug:

• with trophic disorders of the lower extremities;
• with venous insufficiency;
• With thrombophlebitis
• with heaviness in the legs;
• with lymphatic insufficiency;
• with superpermeability of capillaries;
• with exacerbation of hemorrhoids.
• When spider veins appear

Contraindications

Tablets from varicose veins Phlebodia are contraindicated in patients prone to allergies. It is also undesirable to take this drug to patients with chronic kidney and liver diseases.

Side effects

Side effects include the appearance of allergies, stomach upset, and headache. Often this drug does not cause negative effects, so it can be taken during pregnancy, but only after consulting a doctor.

How to drink medicine?

Treatment of varicose veins is effective if the drug is taken correctly. Very often, patients are interested in:

“How often can I take this drug?”, Or “How to take it: before meals or after?”. Many people are interested in the answer, so you can read this information further.

The medicine must be taken as a tablet before meals, preferably in the morning. The course of treatment is a month, in some cases - two months. It depends primarily on the extent to which the veins in the legs are affected and the degree of the disease.

Phlebodia with varicose veins of the small pelvis helps to increase the tone of the veins, as well as the microcirculation of blood in them, has an anti-inflammatory effect, helps to reduce blood stasis in the veins. However, such a cure for varicose veins of the legs requires compliance with special rules during treatment. First of all, you should:

• Avoid prolonged sun exposure.
• Monitor your weight and try to reduce it as much as possible (in case of obesity).
• To walk outside.
• Combine treatments (take pills, ointments and wear special clothing).

It is not easy to follow such rules, especially at first, but this will ensure an effective and quick recovery and help avoid the negative consequences of a disease such as varicose veins.

The method of using the drug for various diseases

Depending on the disease and its degree, dosages vary.

1. Phlebodia with hemorrhoids.

During hemorrhoids, the drug is allowed to take 2 or 3 tablets per day. Reception to carry out during meals. The course of treatment is 7 days.

With hemorrhoids, this drug can reduce the occurrence of hemorrhoidal veins, helps to neutralize inflammation, pain and discomfort.

1. Phlebodia with varicose veins.

This drug is indicated for use in combination with other venotonic drugs. Compliance with such a treatment regimen allows you to:

• slow down the further progression of the disease;
• prevent possible complications;
• relieve pain and reduce swelling of the legs.

Phlebodia should be taken once a day before breakfast in the morning. The course of treatment is from 2 to 6 months, depending on the degree of the disease.

1. Phlebodia during pregnancy.

In pregnancy, this drug is indicated for the treatment of chronic lymphovenous insufficiency in the last two trimesters of pregnancy (second and third trimesters).

It should be noted that when taking Phlebodia, it is necessary to stop taking 14 days before the date of the expected birth. Overdose of drugs during pregnancy has not been identified. Feedback from patients during this period is positive.

Instructions from the drug packaging

How much does this drug cost?

The price of a drug such as Phlebodia directly depends on the region of purchase and on the number of tablets.

For example, when buying "Flebodia 600" No. 15, you will need to pay from 395 to 695 rubles.

And when buying "Flebodia 600" No. 30, the cost will be approximately from 685 to 1742 rubles. for packing. You can buy this drug at any pharmacy or pharmacy.

Phlebodia and alcohol

The drug is compatible with alcohol. This means that alcohol does not affect the effect of the drug. However, this should not be abused, since taking this drug is often combined with other venotonics, and those, in turn, are not always compatible with alcohol.

Phlebodia when taking ok (oral contraceptives)

Quite often, many women are interested in the question of whether it is possible to take oral contraceptives in combination with Phlebodia 600 venotonic. The answer is yes, you can. This drug is approved for use in combination with contraceptives, but a doctor's consultation is necessary before taking.

Analogues

Among the analogues of Phlebodia 600, the following drugs can be distinguished: Vasoket 600 and Diovenor 600. These are generic drugs, that is, they are absolute analogues of Phlebodia 600.

The drug Diosmin is the Russian analogue of Phlebodia. It contains 500 mg of active ingredient.

This drug also differs in the number of excipients, as well as popularity among consumers.

Detralex

The drug Detralex is similar to Phlebodia, but it contains 450 mg of diosmin and 50 mg of hesperidin.

The difference lies in the fact that Detralex is excreted through the gastrointestinal tract, which makes it possible for people with kidney and liver disease to take it.

The drug Venolek contains 500 mg of diosmin. Its difference from Phlebodia is that it causes many side effects.

Quite often, patients complain of rashes, itching, headaches and frequent dizziness.

Some people experience a decrease in blood pressure, vomiting, nausea. Venolek is a cheap analogue of Phlebodia. Excreted by the kidneys and intestines.

There are also analogues that have the same effect as Phlebodia, but they differ in composition, cost and form of release. These include:

• Venarus.
• Troxevasin gel.
• Venoruton.
• Solcoseryl gel.
• Flexital.
• Thromboass.