Phlebodia drug. Phlebodia - instructions for use. Terms and conditions of storage

A variety of pathologies of the veins are increasingly forcing a person to resort to the help of a doctor. In the earliest stages of the disease, there is a high chance of correcting the problem with conservative methods. When pathology affects large areas, doctors insist on a surgical operation or other minimally invasive intervention. However, even after this procedure, the patient is forced to take appropriate medications. One of these is Phlebodia 600. The price, reviews and analogues of the drug will be described in this article. You will also learn about the composition of the medicine. It is worth mentioning that the instructions for use inform about the tablets "Flebodia 600". Reviews of doctors about the use during pregnancy are described below.

What is included in the preparation?

About the drug "Flebodia 600" reviews are mostly positive. All because of its simple composition. The active ingredient of the drug is diosmin in the amount of 600 milligrams. However, there is no hesperidin, which is present in most of these drugs. That is why patients who have intolerance to the latter substance can take Phlebodia 600 without any fear.

Instructions, manufacturers' reviews also report that additional substances are present in the preparation. These are colloidal silicon dioxide and talc, also acid and MCC. The remaining components do not have a therapeutic effect on the body, but are intended only to give the drug the appropriate form.

How does the drug work?

The medicine "Flebodia 600" has good reviews because of the quick effect. The drug begins to act within two hours. However, its maximum effect appears only after 9 hours. It is at this time that the concentration of the active substance in the blood is at its highest level. Consumers also prefer this medication due to the fact that its effectiveness lasts up to 96 hours. Only on the fourth day after application, the composition is completely removed from the patient's body.

What else can the instruction tell about the drug "Flebodia 600"? Consumer reviews report that the annotation indicates pharmacological actions. So, the drug has anti-inflammatory and anti-edematous efficacy. It affects the walls of blood vessels and veins, and also affects the blood. The drug reduces the extensibility of capillaries and helps to increase their tone. It also reduces the binding of leukocytes to the walls of blood vessels. A slight thinning of the blood contributes to the normalization of its outflow from the lower extremities. In addition, the drug fills the blood vessels and veins with oxygen, which improves the patient's condition.

Information on indications for the use of the composition "Flebodia 600"

The drug should be prescribed exclusively by a doctor. Incorrect use of the composition or abuse of doses leads to the development of an unpleasant side reaction. You will be told about it a little later. First, it is worth mentioning the indications for the use of the drug. The annotation indicates the following situations:

• hemorrhoids of various types in the stage of exacerbation or remission;
• soreness and swelling of the lower extremities;
• and spider veins;
• violations of microcirculation of blood and lymph;
• after phlebectomy or minimally invasive interventions for the treatment of venous insufficiency.

Often about the drug "Flebodia 600" reviews report that it is used as a prophylaxis. In this case, the medicine is recommended in the initial stages of venous disease, during pregnancy, with sedentary work and wearing uncomfortable shoes. Indications for use in each individual case may be different. That is why it is worth contacting doctors before using the composition.

Contraindications for use and restrictions

The drug is not prescribed for those patients who are hypersensitive to the components. Also, tablets are prohibited for use by persons under 18 years of age. Such use is fraught with consequences, since in adolescence the lymphatic system continues to form and grow and the Composition is not prescribed for bleeding of unclear etiology, because it can aggravate an already serious problem.

Medication "Flebodia 600" is not recommended during lactation. The active substance is able to penetrate into breast milk and affect the child. However, the consequences of this influence have not yet been studied. Also, the instructions for use do not recommend taking the drug during pregnancy. However, this view is disputed.

Use during pregnancy: a controversial issue

Often women ask if it is possible to use the drug "Flebodia 600" during pregnancy. Reviews of doctors report that the medicine can be prescribed. However, it is worth abandoning it in the first trimester. After all, it is then that the formation of all systems and organs of the unborn child takes place. The medicine does not render Despite it, many doctors are reinsured and register a medicine only in the second half of term.

About the use of the drug "Flebodia 600" during pregnancy, the reviews are only positive. Women report that they have practically no anxiety from the venous system of the lower extremities. Also, hemorrhoids, which often affects future and new mothers, did not make themselves felt. Doctors say that in order to prevent Phlebodia during pregnancy, it is rarely prescribed. Usually the drug is prescribed already in the presence of problems at present or in history.

How to use the composition

How is the drug "Flebodia 600" used? Consumer reviews and doctors' recommendations suggest that the composition is best taken in the morning. In this case, the tablets should be written down with a small amount of pure water. The dosage of the medicinal composition is selected individually in each case. Most often, the following schemes for the use of the drug are prescribed.

• With varicose veins and its manifestations, as well as after surgical interventions, the medication is prescribed 600 milligrams once a day. The term of application is up to two months.
• During hemorrhoids, the dose of the drug is 1200-1800 milligrams per day. Duration of application - up to one week.
• During pregnancy, the medication is taken one capsule per day for a month. This is followed by a short break. The pattern is then repeated.

"Flebodia 600": price, reviews, analogues

Like any other medicine, the described medicine can be replaced. Often consumers ask the question: which is better, "Detralex" or "Flebodia 600". Reviews of doctors say that both of these drugs have the same active ingredient - diosmin. However, in Detralex it is only 450 milligrams. Also in this preparation contains hesperidin in the amount of 50 mg. If the patient has an intolerance to this substance, then the Detralex medicine is not suitable for him. It is because of this that most consumers buy the original drug. One pack of 15 pieces costs about 700 rubles. If you buy a pack of 30 capsules, then it will cost you 1000 rubles. The cost of "Detralex" is somewhat different. One pack with 30 tablets will cost you 800 rubles.

Another analogue of the drug is the Russian medicine Venarus. This tool is even cheaper - 500 rubles for 30 capsules. Its composition is absolutely identical to Detralex. If we talk about substitutes with other components, but with the same effect, then Troxevasin (300 rubles), Antistax (600 rubles) and many others can be noted. According to patients, of all the compositions presented, Phlebodia is the most effective.

The effectiveness of the composition in the treatment of hemorrhoids

What is the drug "Flebodia 600" reviews for hemorrhoids? Consumers report that the composition gives a very fast effect. Convenient and its use. Since most of the compositions for the treatment of such diseases are applied topically, this creates discomfort for the patient.

Consumers say that Phlebodia helps with hemorrhoids already on the first day after application. So, the pain in the affected area goes away. The inflammatory process is also eliminated. It is worth noting that with hemorrhoids, doctors recommend re-using the drug once every six months. Such a scheme will help to avoid relapse.

Phlebodia 600 (active ingredient - diosmin) - the original venoprotector from the French pharmaceutical company "Laboratory Innotec International". The drug has a venotonic effect (increases their tone in a dose-dependent manner, reduces extensibility, prevents venous congestion), accelerates the outflow of lymph, thereby ensuring the implementation of the drainage function (tones and increases the frequency of contraction of the muscular membrane of the lymphatic capillaries, increases their functional activity, reduces pressure in the lymphatic channel) , stimulates blood flow in the capillary bed (dose-dependently increases vascular resistance, reduces the permeability of capillary walls), prevents leukocytes from sticking to the walls of the veins and inhibits their movement into paravenous tissues, improves the diffusion of molecular oxygen and promotes oxygenation of the skin tissue. In addition to this, Phlebodia 600 exhibits an anti-inflammatory effect, enhances the vasoconstrictor effect of catecholamines, blocks the reproduction of free radicals, the synthesis of inflammatory mediators and allergic reactions of prostaglandins and thromboxane. The drug is rapidly absorbed in the gastrointestinal tract and enters the systemic circulation in therapeutically significant concentrations within 2 hours after administration. The maximum concentration of the active substance in the blood plasma is observed 5 hours after ingestion. The drug is evenly distributed and accumulates in the thickness of the walls of the vena cava and superficial veins of the legs, as well as, to a lesser extent, in the internal organs (kidneys, liver, lungs). The accumulation of Phlebodia 600 and its metabolites in the vessels of the venous bed reaches its highest rate at 9 hours after oral administration and persists for 4 days. The main part of the drug is excreted by the kidneys, the remaining amount - through the intestines.

Phlebodia 600 is available in the form of tablets. Before starting a medication course, you should consult with a specialist. In case of varicose veins with the localization of the pathological process in the veins of the lower extremities, as well as with swelling, pain and convulsions, which are the result of chronic lymphovenous insufficiency, the drug is taken on an empty stomach, 1 tablet per day.

The duration of treatment is usually 2 months. In acute hemorrhoids (or exacerbation of chronic) Phlebodia 600 take 2-3 tablets per day with meals for 1 week. If, for some reason, the drug is missed, it is not necessary to compensate for the missed doses by taking additional doses (pharmacotherapy continues as usual at the same doses). Treatment of acute hemorrhoids should be complex (in other words, not based on one drug). If the clinical effect is not sufficiently pronounced, the patient should be referred for additional examination and adjustments to the treatment should be made.

The effectiveness of Phlebodia 600 has been demonstrated in a number of clinical studies, the largest of which involved about 7,000 patients. In this study, participants took 1 tablet of the drug per day (in acute cases - 2 tablets). Patients were subjected to a medical examination before and at the end of the first month of treatment. In general, the observation lasted for 2 months. Study participants were instructed to forego other phlebotonics and to avoid significant adjustments to their lifestyle and routine habits (including food preferences and physical activity levels). The results obtained at the end of the clinical trial made it possible to state the high therapeutic efficacy of Phlebodia 600 and to determine the optimal ways of using the drug. The drug showed itself from the best side, surpassing its competitors in the pharmacological "niche". So, when using Phlebodia 600, more than 80% of positive outcomes were obtained, while for other venotonics this figure did not exceed 40%. The dependence of the effectiveness of therapy on its duration was noted. So, the good results obtained by the end of the first month of the drug course, provided that the drug is continued, are transformed into excellent ones.

Pharmacology

The drug has a phlebotonizing effect (reduces vein extensibility, increases vein tone (dose-dependent effect), reduces venous congestion), improves lymphatic drainage (increases the tone and frequency of contraction of lymphatic capillaries, increases their functional density, reduces lymphatic pressure), improves microcirculation (increases the resistance of capillaries (dose-dependent effect), reduces their permeability), reduces the adhesion of leukocytes to the venous wall and their migration to paravenous tissues, improves oxygen diffusion and perfusion in the skin tissue, and has an anti-inflammatory effect. Enhances the vasoconstrictive action of adrenaline, norepinephrine, blocks the production of free radicals, the synthesis of prostaglandins and thromboxane.

Pharmacokinetics

Rapidly absorbed from the gastrointestinal tract, found in plasma 2 hours after ingestion. C max in blood plasma is achieved 5 hours after ingestion. It is evenly distributed and accumulated in all layers of the wall of the vena cava and saphenous veins of the lower extremities, to a lesser extent - in the kidneys, liver and lungs and other tissues.

The selective accumulation of diosmin and / or its metabolites in the venous vessels reaches a maximum by 9 hours after ingestion and persists for 96 hours. Excreted by the kidneys - 79%, intestines - 11%, with bile - 2.4%.

Release form

Pink, film-coated tablets, round, biconvex.

Excipients: talc - 10.24 mg, colloidal silicon dioxide - 3.5 mg, stearic acid - 50.05 mg, microcrystalline cellulose - up to 910 mg.

The composition of the film shell: Sepifilm ® 002 (hypromellose (E 464) - 9.832 mg, microcrystalline cellulose - 7.866 mg, macrogol 8 stearate type 1 - 1.967 mg); Sepispers ® AP 5523 pink (propylene glycol - traces, hypromellose (E 464) - 0.458 mg, titanium dioxide (E 171) - 4.026 mg, crimson dye [Ponso 4R] (E 124) - 0.401 mg, iron oxide black (E 172) - 0.13 mg, iron oxide red (E 172) - 0.02 mg); Opagloss ® 6000 (Carnauba wax (E 903) - 0.075 mg, beeswax (E 901) - 0.075 mg, shellac (E 904) - 0.15 mg, ethanol 95 ° - traces).

15 pcs. - Al/PVC blisters (1) - cardboard packs.
15 pcs. - Al/PVC blisters (2) - cardboard packs.

Dosage

Before using the drug, you should consult your doctor. The drug is intended for oral administration.

With varicose veins of the lower extremities and chronic lymphovenous insufficiency (edema, pain, convulsions), 1 tab. / day is prescribed. on an empty stomach in the morning. The duration of therapy is usually 2 months.

With exacerbation of hemorrhoids, the drug is prescribed 2-3 tablets / day. during meals for 7 days.

If one or more doses of the drug are missed, it is necessary to continue using the drug as usual and at the usual dose.

Overdose

Overdose symptoms are not described.

Interaction

Clinically significant interaction effects with other drugs have not been described.

Side effects

In rare cases, hypersensitivity to the components of the drug, requiring a break in treatment: on the part of the gastrointestinal tract - dyspeptic disorders (heartburn, nausea, abdominal pain), on the part of the central nervous system - headache.

If any of the side effects listed in the instructions get worse, or if you notice any other side effects not listed in the instructions, tell your doctor.

Application features

Use during pregnancy and lactation

So far, in clinical practice, there have been no reports of any side effects when using the drug in pregnant women. Application during pregnancy in the II and III trimesters is possible only on prescription in cases where the expected benefit to the mother outweighs the potential risk to the fetus.

In experimental studies, no teratogenic effects on the fetus have been identified. During breastfeeding, the drug is not recommended, because. there is no data on the penetration of the drug into breast milk.

Use in children

special instructions

Treatment of an acute attack of hemorrhoids is carried out in combination with other drugs, in the absence of a rapid clinical effect, it is necessary to conduct an additional examination and adjust the ongoing therapy.

Influence on the ability to drive vehicles and control mechanisms

There is no evidence of a negative effect of the drug on the ability to drive vehicles and other mechanisms.

Phlebodia 600 is a drug that helps fight varicose veins in the legs. Phlebodia belongs to the group of angioprotective drugs. This means that the action of this drug is aimed at protecting and restoring already weakened veins that have lost their tone.

The venotonic effect of the drug is caused by its constituent - diosmin. This is an active substance that has a direct effect on the human body as a whole.

The drug Phlebodia 600 has many analogues in its main component, but they all differ in many additional (auxiliary) substances. The manufacturer of this drug is the French laboratory INNOTHERA CHOUZY.

Release form and composition

Phlebodia 600 is available in tablet form. Tablets are convex, round, 15 pieces in a blister. Usually a pack contains 1 or 2 blisters, that is, a package contains 15 or 30 tablets.

The composition includes the active substance diosmin. The dosage of diosmin is 600 mg. Among the excipients, microcrystalline cellulose at a dosage of 910 mg, stearic acid - 50.05 mg, colloidal silicon dioxide - 3.5 mg and talc - 10.24 mg can be distinguished.

Indications for use

Instructions for use shows this drug:

• with trophic disorders of the lower extremities;
• with venous insufficiency;
• With thrombophlebitis
• with heaviness in the legs;
• with lymphatic insufficiency;
• with superpermeability of capillaries;
• with exacerbation of hemorrhoids.
• When spider veins appear

Contraindications

Tablets from varicose veins Phlebodia are contraindicated in patients prone to allergies. It is also undesirable to take this drug to patients with chronic kidney and liver diseases.

Side effects

Side effects include the appearance of allergies, stomach upset, and headache. Often this drug does not cause negative effects, so it can be taken during pregnancy, but only after consulting a doctor.

How to drink medicine?

Treatment of varicose veins is effective if the drug is taken correctly. Very often, patients are interested in:

“How often can I take this drug?”, Or “How to take it: before meals or after?”. Many people are interested in the answer, so you can read this information further.

The medicine must be taken as a tablet before meals, preferably in the morning. The course of treatment is a month, in some cases - two months. It depends primarily on the extent to which the veins in the legs are affected and the degree of the disease.

Phlebodia with varicose veins of the small pelvis helps to increase the tone of the veins, as well as the microcirculation of blood in them, has an anti-inflammatory effect, helps to reduce blood stasis in the veins. However, such a cure for varicose veins of the legs requires compliance with special rules during treatment. First of all, you should:

• Avoid prolonged sun exposure.
• Monitor your weight and try to reduce it as much as possible (in case of obesity).
• To walk outside.
• Combine treatments (take pills, ointments and wear special clothing).

It is not easy to follow such rules, especially at first, but this will ensure effective and quick recovery and help avoid the negative consequences of a disease such as varicose veins.

The method of using the drug for various diseases

Depending on the disease and its degree, dosages vary.

1. Phlebodia with hemorrhoids.

During hemorrhoids, the drug is allowed to take 2 or 3 tablets per day. Reception to carry out during meals. The course of treatment is 7 days.

With hemorrhoids, this drug can reduce the occurrence of hemorrhoidal veins, helps to neutralize inflammation, pain and discomfort.

1. Phlebodia with varicose veins.

This drug is indicated for use in combination with other venotonic drugs. Compliance with such a treatment regimen allows you to:

• slow down the further progression of the disease;
• prevent possible complications;
• relieve pain and reduce swelling of the legs.

Phlebodia should be taken once a day before breakfast in the morning. The course of treatment is from 2 to 6 months, depending on the degree of the disease.

1. Phlebodia during pregnancy.

In pregnancy, this drug is indicated for the treatment of chronic lymphovenous insufficiency in the last two trimesters of pregnancy (second and third trimesters).

It should be noted that when taking Phlebodia, it is necessary to stop taking 14 days before the date of the expected birth. Overdose of drugs during pregnancy has not been identified. Feedback from patients during this period is positive.

Instructions from the drug packaging

How much does this drug cost?

The price of a drug such as Phlebodia directly depends on the region of purchase and on the number of tablets.

For example, when buying "Flebodia 600" No. 15, you will need to pay from 395 to 695 rubles.

And when buying "Flebodia 600" No. 30, the cost will be approximately from 685 to 1742 rubles. for packing. You can buy this drug at any pharmacy or pharmacy.

Phlebodia and alcohol

The drug is compatible with alcohol. This means that alcohol does not affect the effect of the drug. However, this should not be abused, since taking this drug is often combined with other venotonics, and those, in turn, are not always compatible with alcohol.

Phlebodia when taking ok (oral contraceptives)

Quite often, many women are interested in the question of whether it is possible to take oral contraceptives in combination with Phlebodia 600 venotonic. The answer is yes, you can. This drug is approved for use in combination with contraceptives, but a doctor's consultation is necessary before taking.

Analogues

Among the analogues of Phlebodia 600, the following drugs can be distinguished: Vasoket 600 and Diovenor 600. These are generic drugs, that is, they are absolute analogues of Phlebodia 600.

The drug Diosmin is the Russian analogue of Phlebodia. It contains 500 mg of active ingredient.

This drug also differs in the number of excipients, as well as popularity among consumers.

Detralex

The drug Detralex is similar to Phlebodia, but it contains 450 mg of diosmin and 50 mg of hesperidin.

The difference lies in the fact that Detralex is excreted through the gastrointestinal tract, which makes it possible for people with kidney and liver disease to take it.

The drug Venolek contains 500 mg of diosmin. Its difference from Phlebodia is that it causes many side effects.

Quite often, patients complain of rashes, itching, headaches and frequent dizziness.

Some people experience a decrease in blood pressure, vomiting, nausea. Venolek is a cheap analogue of Phlebodia. Excreted by the kidneys and intestines.

There are also analogues that have the same effect as Phlebodia, but they differ in composition, cost and form of release. These include:

• Venarus.
• Troxevasin gel.
• Venoruton.
• Solcoseryl gel.
• Flexital.
• Thromboass.

Phlebodia 600: instructions for use and reviews

The drug Flebodia instructions for use refers to angioprotectors. It helps to strengthen and protect blood vessels from damage. Patient reviews and doctors' recommendations indicate that this drug helps in the treatment of varicose veins and hemorrhoids.

Release form and composition

Pharmacies receive film-coated tablets, Phlebodia 600 mg. Granular diosmin (the main active ingredient of the drug), which corresponds to purified anhydrous - 600 mg.

pharmachologic effect

The drug has a venotonic effect, reduces congestion in the veins, improves their tone. At the same time, the drug increases the resistance of capillaries, improving microcirculation and lymphatic drainage. It has an anti-inflammatory effect, normalizes the blood supply to the skin.

Phlebodia is rapidly absorbed from the gastrointestinal tract, begins to be detected in the blood plasma after about 2 hours. The maximum concentration of the drug in plasma occurs after 5 hours.

Why is Phlebodia 600 prescribed?

Indications for the use of the drug include:

• chronic venous insufficiency;
• prevention and treatment of insufficiency of the lymphatic bed;
• increased fragility of capillaries;
• the initial stages of development of hemorrhoids or hemorrhoidal crisis;
• feeling of heaviness in the legs, especially in the evening;
• varicose veins of the lower extremities;
• burning in the lower extremities in a horizontal position;
• microcirculation disorders.

Instructions for use

With varicose veins of the lower extremities and in the initial stage of chronic lymphovenous insufficiency (heaviness in the legs), Phlebodia instructions for use prescribe to take 1 tablet per day in the morning on an empty stomach for 2 months.

In severe forms of chronic lymphovenous insufficiency (edema, pain, convulsions) - treatment is continued for 3-4 months, in the presence of trophic changes and ulcers - 6 months or more. The course of treatment is repeated after 2-3 months.

In the treatment of chronic lymphovenous insufficiency in the 2nd and 3rd trimesters of pregnancy, 1 tablet is prescribed 1 time per day and canceled 2-3 weeks before delivery. If one or more doses are missed, the drug should be continued at the usual dose.

In case of exacerbation of hemorrhoids, 2-3 tablets per day are prescribed during a meal for 7 days, then, if necessary, you can continue taking 1 tablet 1 time per day for 1-2 months.

Contraindications

There are several pathological and physiological conditions of the human body that are contraindications for taking Flebodia 600 tablets, these include:

• The patient's age is up to 18 years.
• Before starting the use of the drug, it is important to exclude the presence of contraindications in the patient.
• Individual intolerance to any of the components of the drug.
• Pregnancy (especially in the first trimester), as well as the period of breastfeeding in women.

Side effects

The drug Phlebodia, as a rule, is well tolerated, providing the maximum therapeutic effect without side effects. However, in the clinical practice of some qualified specialists, adverse reactions such as:

• allergic manifestations (rashes, pruritus, angioedema, and so on);
• dyspeptic disorders (vomiting, nausea, pain in the upper abdomen, bad breath);
• headache or dizziness.

Such side effects do not require treatment and disappear on their own after a short break in conservative therapy.

Children, during pregnancy and lactation

So far, in clinical practice, there have been no reports of any side effects when using the drug in pregnant women. Use during pregnancy in the 2nd and 3rd trimesters is possible only as directed by a doctor in cases where the expected benefit to the mother outweighs the potential risk to the fetus.

In experimental studies, no teratogenic effects on the fetus have been identified. During breastfeeding, the drug is not recommended, because. there is no data on the penetration of the drug into breast milk.

special instructions

In the treatment of hemorrhoids, Phlebodia 600 is used as part of complex therapy. In the absence of a therapeutic effect, it is necessary to consult a doctor and adjust the dose of the drug. Taking the drug does not affect the ability to drive vehicles or other complex mechanisms.

drug interaction

No significant effects have been described with the combined use of drugs with Phlebodia tablets.