Efferalgan syrup: indications, instructions for use, composition, dosage and side effects. Instructions for use efferalgan syrup for children from temperature Is it possible for children to take efferalgan

Instructions for use:

Efferalgan is a drug belonging to the group of analgesics-antipyretics.

pharmachologic effect

Efferalgan is a non-narcotic analgesic that also has an antipyretic effect. At the heart of its therapeutic action is the mechanism of blocking COX1 and COX2 in the central nervous system with a subsequent effect on the centers of thermoregulation and pain.

The lack of an anti-inflammatory effect is explained by the neutralization of the effect of paracetamol on COX. Neutralization is carried out by cellular peroxidases in inflamed tissues.

The drug does not adversely affect the water-salt balance (does not retain water and Na +) and the gastrointestinal mucosa due to the fact that Efferalgan does not block the synthesis of prostaglandins in peripheral tissues.

Efferalgan release form

For the convenience of using Efferalgan, there are various forms of release of the drug:

• Syrup with a viscous consistency and caramel-vanilla aroma. The color of the syrup is yellow-brown. Efferalgan syrup is packaged in 90 ml bottles. The bottle and the included measuring spoon are placed in a cardboard box;
• White suppositories intended for rectal use. They have a smooth glossy surface. Suppositories are packaged in blisters in the amount of 5 pieces. One carton contains 2 packs;
• The tablets are flat and round. The tablets have beveled edges and a notch on one side, their color is white. The dissolution of tablets in water is accompanied by the active release of gas bubbles. Tablets in the amount of 4 pieces are packed in strips, in one box there are 4 or 25 strips;
• Effervescent tablets containing vitamin C. The release form and appearance are the same as for regular Efferalgan tablets. Packed tablets in tubes of 10 pieces. One carton contains one tube.

There are also special forms of medicine intended for children:

• An effervescent powder intended for the preparation of a solution for oral administration;
• Solution for oral administration;
• Rectal suppositories.

Indications for the use of Efferalgan

According to the instructions for Efferalgan, the drug is recommended for use in the following cases:

• As an antipyretic for influenza, acute respiratory diseases, post-vaccination reactions, childhood infections and other diseases characterized by the appearance of inflammation and fever against the background of infection;
• As a drug with an analgesic effect, with pain syndromes of moderate or low intensity (including toothache, headache, muscle pain, pain caused by injuries and burns, neuralgia).

Contraindications

Medical reviews about Efferalgan note the presence of a number of contraindications, the list of which should be read before starting to use the drug:

• Impaired liver and / or kidney function in severe forms;
• State of deficiency of glucose-6-phosphate dehydrogenase;
• Various blood diseases;
• Age less than one month;
• Hypersensitivity to any of the components of Efferalgan, especially to parabens (propyl and methyl parahydroxybenzoate).

Instructions for use Efferalgan

The instruction to Efferalgan prescribes to take the drug orally (unless otherwise indicated), drinking plenty of water. At least 1 hour, but not more than 2 hours, should elapse between the intake of food and the use of the medicine.

The dosage varies depending on the age of the patient:

• For adults and adolescents over 12 years of age (if their weight exceeds 40 kg), a single dose is 500 mg, the maximum single dose is 1 g. The frequency of use is no more than 4 times a day. The maximum dose per day is 4 g. The duration of treatment should not be more than 5 days - one week;
• Children up to 6 months. and less than 7 kg, a dose equal to no more than 350 mg of Efferalgan per day is prescribed; children under one year old (whose weight is less than 10 kg) - 500 mg; children under 3 years old and weighing less than 15 kg - 750 mg; children under 6 years of age and weighing less than 22 kg - 1 g of medication; up to 9 years and less than 30 kg - 1.5 g; up to 12 years and less than 40 kg - 2 g of Efferalgan maximum. If the child's age is less than 3 months, but more than 1 month, the doctor prescribes the dosage.

The interval between doses of the medicine should be at least 4 hours. The duration of taking Efferalgan without medical advice cannot be more than 3 days (to reduce fever) and no more than 5 days if the drug is used as an analgesic.

Efferalgan should also be administered rectally, focusing on the age of the patient: the dosage for adults is 500 mg from 1 to 4 times a day, the maximum single dose is 1 g, the daily dose is 4 g. For children from 12 to 15 years old, Efferalgan is recommended in the amount of 250-300 mg from 3 to 4 times in one day; children whose age is from 8 to 12 years should take the drug in the same dosage three times a day; from 6-8 years, the required dosage is the same, the frequency is reduced to 2-3 times; from 4 to 6 years - 150 mg 3-4 times a day; for children from 2 to 4 years old, the dose is the same, the frequency is up to 3 times; from one to two years - 80 mg 3 or 4 times a day; from six months to a year - the same dosage with a frequency of 2-3 times; from 3 months to six months, take 80 mg no more than 2 times daily.

Side effects of Efferalgan

The use of Efferalgan can lead to the appearance of unwanted reactions. They are described below:

• Allergic reactions in the form of angioedema, itching, skin rash;
• Vomiting, nausea, pain and pain in the abdomen, hepatotoxic effects;
• Leukopenia, anemia, agranulocytosis, pancytopenia, methemoglobinemia, thrombocytopenia;
• Nephrotoxic effect that occurs with prolonged use of Efferalgan in high doses.

special instructions

Medical reviews about Efferalgan note the likelihood of increasing the maximum allowable daily dose while taking the drug with other drugs that contain paracetamol.

The absence of a therapeutic effect (preservation of symptoms of fever for more than 3 days and pain for more than 5 days) is a reason to seek medical advice.

Patients with diabetes mellitus, as well as patients on a diet that involves the exclusion of sugar, should be borne in mind that 1 ml of the drug contains sugar in the amount of 0.335 g.

Storage conditions

Efferalgan should be stored at a temperature not exceeding 30 ° C, away from children. The shelf life is 3 years.

Antipyretic drugs are always in the medicine cabinet. An important point in taking any of them is not to resort to medical assistance until the temperature index passes the mark of 38 degrees. The body itself must learn to resist the virus and produce antibodies.

Efferalgan is one of the remedies that effectively and quickly fight high temperatures, are allowed for children and are not addictive. It is sold without a prescription, so when using it, follow the instructions.

Composition and properties of Efferalgan syrup for children

Efferalgan UPSA is a modern antipyretic that allows you to quickly bring down a high temperature. It comes in three forms:

1. Effervescent tablets. They are white flat round pills. There is a stripe on one side. Sold in blister packs of 4. Upon contact with water, they begin to dissolve, while actively releasing gas bubbles.
2. Syrup. It is released in vials designed for 90 ml of solution. Usually a special measuring spoon is included in the kit. The syrup itself is a viscous yellow-brown solution that smells of caramel and vanilla.
3. Rectal suppositories. White, glossy and smooth. Released in blisters of 10 pieces.

For children, Efferalgan is recommended in the form of a syrup. Its main active ingredient is paracetamol - 3 grams per 100 ml of the product. The excipients included in the composition are as follows (their quantitative content in grams per 100 ml is indicated in brackets):

• sugar solution consisting of sucrose and water (50);
• macrogol 6000 (20);
• citric acid (0.107);
• sodium saccharinate (0.150);
• potassium sorbate (0.400);
• vanilla-caramel flavor (0.200);
• purified water.

The pharmacological action of the drug can be described by three main properties:

• antipyretic;
• painkiller;
• anti-inflammatory.

Paracetamol acts on the centers of pain and thermoregulation by blocking cyclooxygenase in the central nervous system (we recommend reading:). In tissues where the inflammatory process is taking place, its action is neutralized by cellular peroxidases, which explains their minimal anti-inflammatory effect.

After administration, the drug is rapidly absorbed from the gastrointestinal tract. The highest concentration of the substance in the blood plasma is observed after 10 - 60 minutes. In tissues and fluids, the distribution of the active component is well carried out. The drug is excreted through the kidneys with a half-life of 1 to 2 hours.

Indications for use

Efferalgan syrup is prescribed for children from the age of one month to 12 years old with a body weight ranging from 4 to 32 kilograms. The main purpose of the drug is to anesthetize and bring down the temperature.

Efferalgan is prescribed for children from the age of one month for pain relief and fever relief.

As an anesthetic, the drug is prescribed for such types of pain of mild and moderate intensity, such as:

• muscular;
• head;
• dental;
• having a neuralgic character;
• traumatic;
• resulting from burns.

In the second quality, the solution is used for acute respiratory infections and infections that are provoked by the following pathogens:

• staphylococci and streptococci;
• rhinovirus, influenza A and B, parainfluenza;
• golden staphylococcus aureus;
• coli;
• Pneumococcus;
• herpes 1 and 2 types.

When is the drug contraindicated?

The drug is contraindicated in case of high sensitivity to the components and children who have not yet turned 1 month old. In addition to the age limit and individual intolerance, Efferalgan is forbidden to use if the child has:

• malfunctions in the liver, which turned into a severe form;
• lack of the enzyme glucose-6-phosphate dehydrogenase in the body;
• pathology of the circulatory system;
• chronic diseases of internal organs;
• impaired renal function in a severe stage.

In addition to strict restrictions, there are situations when only the attending physician should prescribe the drug and control its intake, since the scheme will differ from the instructions included in the package. This approach is applicable for Gilbert's syndrome and kidney and liver problems with mild or moderate severity.

Instructions for use

Children who are not yet able to drink from a spoon are prescribed rectal suppositories with doses according to the age of the child. In most cases, they resort to the help of the second, more popular form - syrup. The table below lists the dosages of Efferalgan recommended for children of different ages and with different body weights:

When calculating the dosage, it is necessary to focus on body weight. Also, in order to avoid an overdose, it is undesirable to use Efferalgan in conjunction with other drugs that contain paracetamol. The course of treatment should not exceed 5-7 days. If a child takes Efferalgan, he should be given plenty of fluids during this period, especially after taking the syrup.

The drug should be stored in a dark place at temperatures up to 30 degrees and keep out of the reach of children. The shelf life is 3 years. From the moment the vial is opened, the solution is usable for six months. It is forbidden to give the child a remedy if it has expired.

Possible side effects

The antipyretic and analgesic drug has established itself as an effective remedy that is well accepted by the child's body. However, this does not exclude the appearance of a negative reaction in children whose body does not tolerate paracetamol or other components.

Among the side effects that may appear when taking Efferalgan, it should be noted:

• abdominal pain;
• bouts of nausea;
• vomit;
• diarrhea;
• irritation of the rectum;
• malfunctions of the digestive system;
• an allergic reaction that may appear in the form of hives, Quincke's edema, skin rashes and itching.

In rare cases, anemia, leukopenia, agranulocytosis, thrombocytopenia can be observed. With prolonged use, abdominal pain may become regular, and blood pressure may become elevated. There is a risk of anaphylactic shock.

The threat is uncontrolled long-term use without observing the dosage. This causes changes in the composition of the blood, methemoglobinemia and pancytopenia, produces a hepatotoxic and nephrotoxic effect and leads to subsequent problems with the psychological health of the baby.

Consequences of an overdose

With regard to overdose in children, acute paracetamol poisoning can be identified by the appearance of symptoms, including:

• blanching of the skin;
• decrease in body temperature;
• anorexia;
• pain in the stomach;
• sweating.

If, when the above signs occur, you do not seek help from specialists, irreversible processes begin to occur in the cells, which are fraught with the development of acidosis, liver failure, hepatonecrosis, encephalopathy and coma.

After the drug has been discontinued and the child has been hospitalized, treatment is reduced to a number of activities, including:

• gastric lavage;
• intake of enterosorbents (Polifepan or activated carbon);
• intravenous administration of the antidote N-acetylcysteine;
• course of methionine;
• symptomatic therapy.

The cost of the drug and analogues

One of the advantages of the antipyretic drug Efferalgan UPSA is an affordable price. Despite the low cost, the tool is characterized by high efficiency and safety with proper use. On the territory of the Russian Federation, a bottle of Efferalgan 90 mg can be bought for 100 rubles. This price can vary in a range that depends on the city and pharmacy where the medicine is purchased.

Efferalgan is widely used in pediatric medicine due to its speed, safety for babies, minimum side effects and lack of addiction.

Despite all these advantages and availability, alternative drugs of a similar effect should be kept in mind. The pharmacological market provides a huge selection of all kinds of medications with similar properties and characteristics, the main active ingredient of which is paracetamol. Such drugs differ in the country where they were made, and auxiliary elements in the composition.

Among the main analogues of Efferalgan it is worth noting.

◊ Syrup (for children) in the form of a slightly viscous solution of yellow-brown color, with a caramel-vanilla smell.

Excipients: macrogol 6000, sugar syrup (sucrose, water), sodium saccharinate, potassium sorbate, citric acid, caramel-vanilla flavor (butanedione, acetylmethylcarbinol, benzaldehyde, propylene glycol, gamma-heptalactone, benzyl alcohol, triacetin, piperonal, amyl cinnamate, vanillin, acetylvanillin) , purified water.

90 ml - plastic bottles (1) complete with measuring spoon - cardboard boxes.

Clinical and pharmacological group

pharmachologic effect

Analgesic-antipyretic. It has an analgesic and antipyretic effect. Inhibits COX-1 and COX-2 mainly in the central nervous system, affecting the centers of pain and thermoregulation. In inflamed tissues, cellular peroxidases neutralize the effect of paracetamol on COX, which explains the almost complete absence of its anti-inflammatory effect.

It does not adversely affect the water-salt metabolism (sodium and water retention) and the gastrointestinal mucosa due to the lack of influence on the synthesis of prostaglandins in peripheral tissues.

Pharmacokinetics

Suction and distribution

Absorption of paracetamol is complete and rapid. C max in plasma is achieved 30-60 minutes after ingestion. Distribution of paracetamol in tissues occurs quickly. Comparable drug concentrations in blood, saliva and plasma are achieved. Communication with plasma proteins is low (10-25%). Penetrates through the BBB.

Metabolism and excretion

Metabolism occurs in the liver, 80% enters into conjugation reactions with glucuronic acid and sulfates to form inactive metabolites; 17% undergoes hydroxylation with the formation of 8 active metabolites, which are conjugated with glutathione to form already inactive metabolites. With a lack of glutathione, these metabolites can block the enzyme systems of hepatocytes and cause their necrosis. The CYP2E1 isoenzyme is also involved in the metabolism of the drug.

T 1/2 is about 2 hours (1-4 hours). It is excreted by the kidneys in the form of metabolites, mainly conjugates. Less than 5% is excreted unchanged.

Indications for the use of the drug

For children aged 1 month to 12 years (weighing 4 to 32 kg):

- as an antipyretic for acute respiratory infections, influenza, childhood infections, post-vaccination reactions and other conditions accompanied by fever;

- as an anesthetic for pain syndrome of mild or moderate intensity, incl. headache and toothache, muscle pain, neuralgia, pain from injuries and burns.

Dosing regimen

The average single dose depends on the body weight of the child and is 10-15 mg / kg body weight 3-4 times / day. The maximum daily dose should not exceed 60 mg/kg body weight. The interval between doses of the drug should be 4-6 hours. Regular time intervals between taking the drug should be followed.

For convenience and accuracy of dosing, use a measuring spoon. On the measuring spoon, divisions indicating the body weight of the child are applied: 4, 6, 8, 10, 12, 14 or 16 kg. Unmarked divisions correspond to intermediate body weight: 5, 7, 9, 11, 13 or 15 kg.

Children weighing 4 to 16 kg

Fill the measuring spoon to the mark corresponding to the child's body weight, or to the mark closest in value to the child's body weight. For example, if the child's body weight is 4 to 5 kg, fill the measuring spoon to the mark corresponding to 4 kg. If necessary, the drug should be taken every 4-6 hours.

Children weighing 16 to 32 kg

Fill the measuring spoon to the mark corresponding to 10 kg, then refill the measuring spoon to the mark so that the total body weight of the child is obtained. For example, if the child weighs between 18 and 19 kg, fill the measuring spoon to the 10 kg mark, then refill the measuring spoon to the 8 kg mark. If necessary, the drug should be taken every 4-6 hours.

At impaired renal function (CC less than 10 ml / min) the time interval between doses of the drug should be at least 8 hours.

The drug can be given to a child both without dilution and after dilution (with water, milk or juice).

The duration of treatment is 3 days as an antipyretic and up to 5 days as an analgesic. If you need to continue taking the drug, you need to consult a doctor.

Side effect

From the digestive system: possible - diarrhea, abdominal pain, nausea, vomiting, tenesmus; with prolonged use in high doses, a hepatotoxic effect is possible.

Allergic reactions: possible - skin rash, itching, urticaria, Quincke's edema, anaphylactic shock, lowering blood pressure (as a symptom of anaphylaxis).

From the hematopoietic system: rarely - anemia, thrombocytopenia, leukopenia, neutropenia.

Others: decrease or increase in the prothrombin index; with prolonged use in high doses, a nephrotoxic effect is possible.

Contraindications to the use of the drug

- severe liver dysfunction;

- severe renal dysfunction;

- blood diseases;

- deficiency of glucose-6-phosphate dehydrogenase;

- children's age up to 1 month;

- hypersensitivity to the components of the drug

WITH caution the drug should be used for mild to moderate liver or kidney dysfunction, with Gilbert's syndrome.

special instructions

In order to avoid exceeding the maximum daily dose, Efferalgan should not be used simultaneously with other drugs containing paracetamol.

When using the drug for more than 5-7 days, it is necessary to control the pattern of peripheral blood and the functional state of the liver.

Paracetamol distorts the results of laboratory studies of glucose and uric acid in blood plasma.

If it is necessary to prescribe the drug to patients with diabetes mellitus or to patients on a diet with a low sugar content, it should be borne in mind that 1 ml of the drug contains 0.335 g of sugar (0.67 g of sugar per graduation division of a measuring spoon / marked with marks in kg /).

Persons caring for a sick child should be warned about the need to discontinue the drug and consult a doctor in case of adverse reactions. A doctor's consultation is also required in the absence of a therapeutic effect: continued fever for more than 3 days and pain for more than 5 days.

Overdose

Symptoms acute poisoning with paracetamol are nausea, vomiting, anorexia, pain in the epigastric region, sweating, pallor of the skin, appearing in the first 24 hours after ingestion. Taking paracetamol at a dose of 140 mg / kg of body weight in children causes destruction of liver cells, leading to complete and irreversible hepatonecrosis, liver failure, metabolic acidosis, encephalopathy, which, in turn, can lead to the development of coma and death.

12-48 hours after administration, an increase in the level of liver transaminases, LDH and bilirubin may be observed with a simultaneous decrease in the level of prothrombin. The clinical picture of liver damage is usually detected after 1 or 2 days and reaches a maximum after 3-4 days.

Treatment: when symptoms of poisoning appear, it is recommended to stop taking the drug and immediate hospitalization. Blood samples should be taken for the initial determination of the level of paracetamol in the blood plasma. Gastric lavage is performed, enterosorbents are taken (activated charcoal, hydrolytic lignin), the antidote acetylcysteine ​​is administered (in / in or orally) up to 10 hours after taking the drug. Acetylcysteine ​​may be effective 16 hours after an overdose. Symptomatic treatment is also carried out.

drug interaction

With the simultaneous use of Efferalgan with barbiturates, tricyclic antidepressants, anticonvulsants (phenytoin), flumecinol, phenylbutazone, rifampicin, ethanol, the risk of developing a hepatotoxic effect is significantly increased.

When taken together with salicylates, the risk of nephrotoxicity increases significantly.

Salicylamide can prolong T 1/2 of paracetamol.

With simultaneous use with chloramphenicol, the toxicity of the latter increases.

Probenecid leads to an almost two-fold decrease in the clearance of paracetamol due to the suppression of binding to glucuronic acid.

Paracetamol enhances the effect of indirect anticoagulants.

Paracetamol reduces the effectiveness of uricosuric drugs.

Terms of dispensing from pharmacies

The drug is approved for use as a means of OTC.

Terms and conditions of storage

The drug should be stored out of the reach of children at a temperature not exceeding 30°C. Shelf life - 3 years.

The drug is administered orally 1-2 hours after a meal.

The average single dose depends on the body weight of the child and is 10-15 mg / kg body weight 3-4 times / day. The maximum daily dose is 60 mg/kg. The interval between doses is 4-6 hours.

For convenience and accuracy of dosing, use a measuring spoon. The measuring spoon is marked with divisions indicating a single dose (15 mg / kg) for children with body weight 4, 8, 12 or 16 kg respectively. Unmarked divisions correspond body weight 6, 10 or 14 kg.

The ratio of the age and body weight of the child is given approximately.

Children aged 3 months to 6 years (body weight 6-20 kg): fill the measuring spoon to the mark in accordance with the table. For example, if the child's body weight is from 6 to 8 kg, then the measuring spoon should be filled up to the mark corresponding to 6 kg.

Children aged 6 to 12 years (body weight 20-32 kg): fill the measuring spoon to the mark corresponding to 16 kg, then refill the measuring spoon to the mark according to the table. For example, if the child's body weight is between 20 and 22 kg, then fill the measuring spoon to the mark corresponding to 16 kg, then refill the measuring spoon to the mark of 4 kg.

The drug can be given to a child without dilution or after dilution with water or milk.

The duration of treatment is 3 days when used as an antipyretic and up to 5 days as an analgesic. If you need a longer dose of the drug, you need to consult a doctor.

On our website you will find detailed information about the drug EFFERALGAN (syrup) and its instructions for use in Russian. Instructions for use contain information about the composition, indications for use, contraindications, dosage, features of admission in children, during pregnancy and lactation, interaction with other drugs, side effects and overdose of EFFERALGAN. You can also get acquainted with the conditions and shelf life of the drug EFFERALGAN and its analogues.

Registration number:

Tradename: Efferalgan

International non-proprietary name: Paracetamol

Chemical rational name: N-(4-hydroxyphenyl)acetamide

Dosage form: oral solution (for children) 3% (complete with dosing spoon).

Compound

1 ml of the drug contains 30 mg of paracetamol.
excipients: macrogol 6000, sucrose solution, sodium saccharin, sorbic acid, sodium methyl parahydroxybenzoate, sodium propyl parahydroxybenzoate, caramel-vanilla flavor, water.

Description

Transparent, homogeneous, slightly viscous solution of yellow-brown color, with a caramel-vanilla taste and smell.

Pharmacotherapeutic group

Analgesic non-narcotic agent.

ATX code:

Pharmacological properties

Efferalgan contains paracetamol, which has an analgesic and antipyretic effect.

Indications for use

Efferalgan is used in children from 3 months to 12 years (weighing 6 to 32 kg) as an antipyretic for acute respiratory diseases, influenza, childhood infections, post-vaccination reactions and other conditions accompanied by fever.
The drug is also used as an anesthetic for pain syndrome of mild or moderate intensity, including: headache and toothache, muscle pain, neuralgia, pain from injuries and burns.

Contraindications

Do not use this medicine if your child has:

• hypersensitivity to paracetamol or other components of the drug, especially parabens (methyl and propyl parahydroxybenzoate);
• severe violations of the liver, kidneys;
• blood diseases;
• deficiency of the enzyme glucose-6-phosphate dehydrogenase;
• age up to 1 month.

Carefully- The drug should be used with caution in impaired liver or kidney function, with Gilbert's syndrome. Before taking the drug, you should consult with your doctor.

To determine the dose and regimen of taking the drug in children aged 1 to 3 months, it is necessary to consult a doctor.

Dosage and administration

The drug is taken orally with a large amount of liquid 1-2 hours after a meal.
The average single dose of Efferalgan depends on the body weight of the child and is 10-15 mg / kg of body weight 3-4 times a day. The maximum daily dose should not exceed 60 mg/kg body weight. The interval between doses of the drug should be 4-6 hours. For convenience and accuracy of dosing, use a measuring spoon.
The measuring spoon is marked with divisions indicating a single dose (15 mg / kg) for a child with an appropriate body weight: 4, 8, 12 or 16 kg. Unmarked divisions correspond to intermediate body weight: 6, 10 or 14 kg.

Children from 3 months to 6 years (6-20 kg): Fill the measuring spoon to the mark, in accordance with the table. For example, if your child weighs between 6 and 8 kg, fill the measuring spoon up to the mark corresponding to 6 kg.
Children from 6 to 12 years old (20-32 kg): fill the measuring spoon to the mark corresponding to 16 kg, then refill the measuring spoon to the mark according to the table. For example, if your child weighs between 20 and 22 kg, fill the measuring spoon to the 16 kg mark, then refill the measuring spoon to the 4 kg mark.
The drug can be given to a child without dilution or after dilution with water or milk.
Duration of treatment:
3 days as an antipyretic and up to 5 days as an analgesic. If you need to continue taking the drug, you need to consult a doctor.

Side effect

Nausea, vomiting, abdominal pain, allergic reactions (skin rash, itching, urticaria, Quincke's edema) are possible.
Rarely - anemia, leukopenia, agranulocytosis, thrombocytopenia.
With prolonged use in large doses, hepatotoxic and nephrotoxic effects are possible, as well as the occurrence of methemoglobinemia and pancytopenia. If adverse reactions occur, stop taking the drug and consult a doctor.

Overdose

Signs of acute poisoning with paracetamol are nausea, vomiting, stomach pain, sweating, pallor of the skin. After 1-2 days, signs of liver damage appear - pain in the liver, increased activity of "liver" enzymes in the blood, an increase in prothrombin time. In severe cases, liver failure, hepatonecrosis, encephalopathy and coma develop. If symptoms of poisoning occur, stop using the drug and consult a doctor immediately. Recommended gastric lavage, intake of enterosorbents (activated charcoal, polyphepan), intravenous administration of the antidote N-acetylcysteine, methionine intake.

Interaction with other drugs

When using Efferalgan, together with barbiturates, tricyclic antidepressants, anticonvulsants (phenytoin), zixorin, phenylbutazone, rifampicin and alcohol, the risk of developing a hepatotoxic effect is significantly increased.
Reception together with salicylates significantly increases the risk of nephrotoxicity. With simultaneous use with levomycetin (chloramphenicol), the toxicity of the latter increases.
Paracetamol contained in Efferalgan enhances the effect of indirect anticoagulants and reduces the effectiveness of uricosuric drugs.

special instructions

Efferalgan contains paracetamol, therefore, in order to avoid exceeding the maximum daily dose, the drug should not be used simultaneously with other medicines containing paracetamol.
When using the drug for more than 5-7 days, it is necessary to monitor the picture of peripheral blood and the functional state of the liver.
In the case of taking the drug by children suffering from diabetes mellitus or on a low sugar diet, it should be borne in mind that 1 ml of the drug contains 0.335 g of sugar.
Paracetamol distorts the results of laboratory studies of glucose and uric acid in blood plasma.
In the absence of a therapeutic effect: continued fever for more than 3 days and pain for more than 5 days, you should consult your doctor.

Release form

Solution for oral administration in a 90 ml plastic bottle, sealed with a polyethylene “push and open” cap. 1 vial with a measuring spoon and instructions for use in a cardboard box.

Storage conditions

Store at a temperature not exceeding 30 ° C, out of the reach of children.

Best before date

3 years.
Do not use the drug after the expiry date indicated on the package.

Terms of dispensing from pharmacies

Over the counter.

Manufacturer
"Bristol-Myers Squibb", France
304, avenue du Docteur Jean Bra 47000 AGEN – France

Moscow representative office:
123001, Russia, Moscow, Trekhprudny pereulok, building 9, building 1B.