Sorbifer dosage. Sorbifer durules tablets. Release form, composition and packaging

Iron-deficiency anemia;

iron deficiency;

Prevention of iron deficiency during pregnancy, lactation and in blood donors.

Release form of the drug Sorbifer Durules

coated tablets 100 mg + 60 mg; dark glass bottle (vial) 50 carton pack 1.
coated tablets 100 mg + 60 mg; dark glass bottle (flacon) 30 carton pack 1.

Pharmacodynamics of the drug Sorbifer Durules

Iron is an indispensable component of the body, necessary for the formation of hemoglobin and the occurrence of oxidative processes in tissues. Durules® technology provides a gradual release of the active ingredient (iron ions) over a long period of time. The plastic matrix of Sorbifer® Durules® tablets is inert in the digestive juice, but completely disintegrates under the action of intestinal peristalsis when the active ingredient is completely released.

Pharmacokinetics of the drug Sorbifer Durules

Durules® is a technology that ensures the gradual release of the active substance (ferrous ions) from tablets and its uniform flow into the blood. Taking 100 mg 2 times a day provides a 30% greater absorption of iron from the drug Sorbifer® Durules® compared to conventional iron preparations.

Absorption and bioavailability of iron are high. Iron is absorbed predominantly in the duodenum and proximal jejunum. Plasma protein binding - 90% or more. It is deposited in the form of ferritin or hemosiderin in hepatocytes and cells of the system of phagocytic macrophages, a small amount - in the form of myoglobin in muscles. T1 / 2 is 6 hours.

Use of the drug Sorbifer Durules during pregnancy

Can be used during pregnancy and lactation.

Contraindications to the use of the drug Sorbifer Durules

hypersensitivity to the components of the drug;

Esophageal stenosis and / or obstructive changes in the digestive tract;

Increased iron content in the body (hemosiderosis, hemochromatosis);

Violation of iron utilization (lead anemia, sideroblastic anemia, hemolytic anemia);

Children under 12 years of age (due to lack of clinical data).

With caution: peptic ulcer of the stomach and duodenum, inflammatory bowel disease (enteritis, diverticulitis, ulcerative colitis, Crohn's disease).

Side effects of the drug Sorbifer Durules

Nausea, vomiting, abdominal pain, diarrhea or constipation. The frequency of side effects from the gastrointestinal tract may increase with increasing doses from 100 to 400 mg. Rarely (<1/100) - язвенное поражение пищевода, стеноз пищевода, аллергические реакции (зуд, сыпь), гипертермия кожи, головная боль, головокружение, слабость.

Dosage and administration of Sorbifer Durules

Inside, the tablet should be swallowed whole (can not be divided or chewed), drinking at least 0.5 cups of liquid.

Adults and adolescents: 1 tab. 1-2 times a day. If necessary, patients with iron deficiency anemia can increase the dose to 3-4 tablets. per day in 2 divided doses (morning and evening) for 3-4 months (until the iron depot in the body is replenished).

Pregnant women and during lactation: prevention - 1 tab. per day, therapeutic dose - 1 tab. 2 times a day (morning and evening).

Treatment should be continued until the optimal hemoglobin level is reached. For further replenishment of the depot, it may be necessary to continue taking the drug for another 2 months.

Overdose with Sorbifer Durules

Symptoms: abdominal pain, vomiting and diarrhea mixed with blood, fatigue or weakness, hyperthermia, paresthesia, pallor of the skin, cold clammy sweat, acidosis, weak pulse, decreased blood pressure, palpitations. In severe overdose, signs of peripheral circulatory collapse, coagulopathy, hyperthermia, hypoglycemia, liver damage, renal failure, muscle cramps, and coma may occur after 6 to 12 hours.

Treatment: you should immediately consult a doctor. Gastric lavage, inside - a raw egg, milk (to bind iron ions in the digestive tract), the introduction of deferoxamine, symptomatic therapy.

Interactions of the drug Sorbifer Durules with other drugs

May reduce the absorption of concomitantly used enoxacin, clodronate, grepafloxacin, levofloxacin, levodopa, methyldopa, penicillamine, tetracyclines and thyroid hormones. The simultaneous use of the drug Sorbifer® Durules® and antacids containing aluminum hydroxide and magnesium carbonate can reduce the absorption of iron (the interval between their intake should be at least 2 hours), in the case of tetracyclines, the minimum interval should be 3 hours. Sorbifer® Durules® does not should be combined with ciprofloxacin, doxycycline, norfloxacin and ofloxacin.

Special instructions when taking the drug Sorbifer Durules

Possible darkening of the feces (has no clinical significance).

Storage conditions of the drug Sorbifer Durules

At a temperature of 15–25 °C.

Shelf life of the drug Sorbifer Durules

Belonging of the drug Sorbifer Durules to the ATX classification:

B Hematopoiesis and blood

B03 Antianemic drugs

B03A Iron preparations

B03AA Oral iron (ferrous) preparations

Country of origin

Product group

Antianemic drug

Release form

• 30 - dark glass bottles (1) - packs of cardboard. 50 - dark glass bottles (1) - packs of cardboard.

Description of the dosage form

• round, biconvex film-coated tablets, light yellow, with "Z" engraved on one side, on a break, a gray core with a characteristic odor Tablets, coated with a light yellow color, round, biconvex, with "Z" engraved on one side; at the break - the core is gray, with a characteristic odor

pharmachologic effect

Pharmacokinetics

Special conditions

Compound

• Each coated tablet contains ferrous sulfate in an amount equivalent to 100 mg Fe2+ and 60 mg ascorbic acid, as well as: magnesium stearate, povidone K-25, polyethene powder, carbomer 934P. The shell contains: hypromellose, macrogol 6000, titanium dioxide, yellow iron oxide, solid paraffin

Sorbifer Durules indications for use

• - treatment of iron deficiency anemia (with insufficient intake of iron into the body with food, with an increased need for iron in the body; with chronic blood loss); - prevention of iron deficiency anemia (including during pregnancy and lactation, in women of childbearing age, in children and adolescents during a period of intensive growth, in the elderly).

Sorbifer Durules contraindications

• - narrowing of the esophagus and / or other obstructive diseases of the gastrointestinal tract; - pathological conditions caused by increased deposition of iron in the body; - children's age up to 12 years; - hypersensitivity to the drug

Sorbifer Durules side effects

• From the digestive system: mild nausea, epigastric pain, diarrhea or constipation.

drug interaction

Storage conditions

• keep away from children

Content

Anemia is one of the serious consequences of a deficiency in the body of iron, an indispensable element responsible for the oxidative processes of tissues and, most importantly, for the formation of hemoglobin. A good effect in the correction of such a pathology is given by Sorbifer Durules, a Hungarian drug for the treatment of iron deficiency. What are its specifics, indications and contraindications?

What is Sorbifer Durules

Sorbifer is a drug that replenishes iron deficiency in the body, durules is a special technology for creating a drug that prevents the active substances from being released in the stomach under the influence of digestive juice. Instead, iron ions are gradually activated in the intestine due to peristalsis. This mechanism prevents irritation of the mucous membrane of the digestive system and prevents a sharp jump in the level of iron in the body.

Compound

The main active ingredients of the drug are ferrous sulfate (320 mg) and ascorbic acid (60 mg), which increases the absorption of the drug by the walls of the duodenum. Excipients of the tablet composition: polyvidone, polyethylene, carbomer, magnesium stearate. The shell will contain macrogol, hydroxypropyl methylcellulose, titanium dioxide, paraffin and iron oxide.

Release form

What is Sorbifer? These are round, biconvex yellow tablets with a z on each side. Designed for oral administration. At the break - a gray core with a characteristic metallic smell. Pills are packaged in dark glass bottles (the drug is sensitive to direct light exposure), and then in cardboard boxes. The product is intended for oral administration. There are two types of packaging of the drug: 30 and 50 tablets per pack.

pharmachologic effect

The drug has an anti-anemic effect, its active substances increase the level of hemoglobin in the blood. This complex iron-containing protein is part of the blood and is responsible for the transport of oxygen and carbon dioxide. Hemoglobin generation is enhanced due to the fact that ferrous sulfate is included in metabolic processes and directly affects the synthesis of heme, the structural part of hemoglobin. Ascorbic acid promotes the penetration of iron sulfate from the intestinal lumen into the bloodstream.

What are Sorbifer Durules tablets for?

The drug is used to treat only iron deficiency anemia - it is ineffective for anemia caused by other reasons. Recommended after heavy bleeding for the speedy replenishment of blood loss. This is especially true for uterine, nasal and gastrointestinal effusions. The remedy is used to compensate for iron deficiency provoked by any factors: previous diseases, intensive growth during the transition period, regular donation, malnutrition, etc.

Sorbifer can be prescribed for prophylactic purposes to pregnant women, mothers during breastfeeding, blood donors and other conditions characterized by a low level of iron in the body. It is often recommended to athletes for the prevention of latent deficiency associated with the inevitable loss of iron during strenuous exercise.

Instructions for use

How to take Sorbifer Durules correctly is determined by the attending physician. The usual therapeutic dose is 1 tablet 2 times a day. In case of side effects, the dosage can be reduced to one dose per day. In severe cases of anemia, 3-4 tablets per day are prescribed. The treatment course continues until the iron deficiency is completely eliminated (this usually takes about two months). After normalization of indicators, it is recommended to continue taking the drug to create a supply of the substance in the body. For prevention, a maintenance dose is prescribed - 1 tablet per day.

Before meals or after

The summary on how to take Sorbifer Durules reports that it is effective to use it 40-45 minutes before a meal or 2 hours after a meal. You should not take the drug on an empty stomach for people suffering from diseases of the gastrointestinal tract, in order to exclude a possible damaging effect on the gastric mucosa. The tablet is coated - it should not be broken before taking and chewed. The drug should be washed down with a large amount of liquid - at least half a glass.

Instructions for pregnancy

Almost all women suffer from iron deficiency, anemia and a physiological decrease in hemoglobin levels during pregnancy. In order to avoid possible complications (both for the mother and for the child), appropriate prophylactic drugs are prescribed. This is especially true during the second and third trimesters. The iron preparation Sorbifer is often used because it quickly increases the level of essential substances.

The recommended dose for prophylactic purposes during pregnancy is 1 tablet per day. In the treatment of anemia and severe toxicosis, it can be increased to two (depending on the severity of the pathology). The dosage may be increased by the attending physician closer to the birth (last trimester). For the period of taking Sorbifer, women are advised to give up dairy products: the calcium contained in them makes it difficult for the body of a pregnant woman to absorb iron.

Sorbifer Durules while breastfeeding

During the period from the beginning of gestation to the end of breastfeeding, the female body loses approximately 1.4 g of iron, which leads to a serious deficiency of the substance in the body. Sorbifer is effective in its replenishment and safe for the newborn. The recommended dosage is 2 tablets per day. The course lasts 14-20 days. It is not necessary to stop breastfeeding for this period.

During lactation, Sorbifer can be taken only on the recommendation of the attending physician, but even in this case it is advisable to organize the drug intake so that the mother drinks the pill immediately after breastfeeding. You should carefully monitor the condition of the baby: if he feels unwell, Sorbifer is immediately stopped, and it is better to show the child to the doctor.

Sorbifer for children

The drug is not suitable for the treatment of children under 12 years of age due to the lack of clinical data on the use (that is, safety for this age has not been established). After 12 years, the drug can be prescribed based on a daily dosage of 3 mg of the drug per 1 kg of the child's body weight. The first days of admission should closely monitor the condition of the baby. If any side effects or a general deterioration in well-being appear, you should immediately stop taking the tablets. It is advisable to show the child to the doctor.

drug interaction

With the joint use of Sorbifer with D-penicillamine or antibiotics of the tetracycline group, the absorption of both drugs is equally reduced. The agent reduces the effectiveness of thyroid hormones, enoxacin, methyldopa, levodopa, levofloxacin, clodronate, grepafloxacin. Medicines containing calcium, magnesium or aluminum impair iron absorption. Simultaneous use of Sorbifer with Ciprofloxacin, Ofloxacin, Doxycycline, Norfloxacin is unacceptable.

Side effects

The likelihood of pathological negative reactions increases with increasing dosage, but even in a minimal amount, Sorbifer can cause the following side effects:

• nausea and vomiting;
• pain in the abdomen;
• diarrhea or, conversely, constipation;
• ulcerative lesion or stenosis of the esophagus;
• allergic manifestations (rashes, skin itching);
• disorders of the nervous system (headaches, weakness, dizziness);
• unpleasant taste in the mouth;
• skin hyperthermia;
• decreased appetite.

Contraindications

The drug can not be used if the patient is hypersensitive to any of the components of the drug. Medical contraindications for the drug also include the following conditions of the body:

• naturally high levels of iron (for example, with hereditary metabolic disorders);
• inability of the body to properly absorb iron (sideroblastic, lead, aplastic, hemolytic anemia);
• heavy bleeding;
• condition after removal of the stomach;
• narrowing of any part of the digestive tract.

Analogues

To compensate for iron deficiency, treat and prevent anemia, drugs similar in composition to Sorbifer can be used:

• Fenules Zinc is the cheapest possible alternative. Unprofitable with a long course of administration due to the small capacity of the package - only 10 capsules.
• Aktiferrin - is represented by enteric-coated capsules.
• Tardiferon - has a much lower content of ferrous sulfate (80 mg).
• Ferro-Folgamma - has a wider range of both indications and contraindications for use, since the composition of the drug, in addition to iron, has two more active ingredients: cyanocobalamin (vitamin B12) and folic acid.
• Totem - is a solution. Contains additional active substances: copper, iron and manganese gluconates.
• Aktiferrin - comes in the form of oral drops, syrup and capsules. Additionally contains D,L-serine.

special instructions

The interval between taking Sorbifer and any other drug should be at least two hours. Tablets are dispensed by prescription: their independent use is prohibited without the appointment of the attending physician and a preliminary determination of the iron-binding activity of the body. Against the background of taking the drug, there may be a change in the color of feces, in some cases - up to black. This is considered a deviation from the norm - the drug should be stopped.

In case of an overdose, immediately rinse the stomach, drink a raw egg or milk, seek medical help. It is unsafe to drink alcohol during the period of treatment with Sorbifer, since under the influence of alcohol the drug loses its effectiveness, its side effects increase, and other pathological processes are possible. In extreme cases, you should withstand a twelve-hour break between taking the pill and drinking alcohol.

Instructions for use:

Sorbifer (international name - Ferrous sulfate + Ascorbic acid) belongs to the group of antianemic drugs that compensate for the lack of iron. The drug has high efficiency and safety, due to which it is prescribed during pregnancy and breastfeeding.

Sorbifer has been widely used as an effective stimulant to restore iron content in the body after serious illnesses, operations and prolonged bleeding.

Composition and form of release

The main active ingredients are ascorbic acid 60 mg and ferrous sulfate 100 mg.

Auxiliary components: magnesium stearate, polyethylene powder, carbomer, povidone.

Sorbifer is available in tablets of 160 mg in a carton of 30-50 pcs. Each tablet is coated with paraffin, iron oxide, titanium dioxide, hypromellose and macrogol.

Pharmacological properties of Sorbifer

Sorbifer is a combined preparation effective for restoring iron levels in various types of anemia. Thanks to the combination of ferrous sulfate and ascorbic acid, an anti-anemic effect is achieved.

Sorbifer has good reviews as a highly absorbable drug with a gradual release of iron ions, which avoids excess iron in the gastrointestinal tract and blood.

Ferrous sulfate and vitamin C contribute to the production of hemoglobin and oxygen transport. Ascorbic acid acts as an antioxidant and collagen, which provides tissue regeneration.

According to the description, Sorbifer is effective for iron absorption disorders and its chronic deficiency in the body.

Indications for the use of Sorbifer

Sorbifer is prescribed for iron deficiency anemia of various etiologies, including during pregnancy and lactation, in the postoperative period, after severe illness and bleeding, and chronic diarrhea.

Sorbifer received positive feedback as an effective prophylactic drug for diets, unbalanced nutrition and low iron absorption.

Instructions for use

In accordance with the instructions, Sorbifer should be taken orally 2-3 times a day, 2 tablets after a meal, with plenty of water. The daily dose of the drug is 100 - 200 mg, depending on the patient's diagnostic indications.

With iron deficiency anemia, the drug should be taken 2 tablets 2 times a day, and for the prevention of iron deficiency - 100 mg once a day.

According to the instructions, Sorbifer should not be taken by children under 12 years of age.

Application during pregnancy

When diagnosing iron deficiency in a pregnant woman, Sorbifer is prescribed. The drug can be taken both for the treatment and for the prevention of anemia during the second and third trimesters of pregnancy. Sorbifer can also be prescribed for multiple pregnancy with bleeding.

Sorbifer during pregnancy should be taken after meals 2 times a day, one tablet. The daily dose should not exceed 200 mg. The dosage is determined in accordance with the analyzes of the patient. With the correct dosage, hemoglobin rises within 2-3 weeks after the start of administration.

During the period of taking the drug, a pregnant patient should not eat foods and drugs with a high content of calcium. Between taking Sorbifer and antacids should take 2-3 hours.

Sorbifer is contraindicated in pregnant patients with esophageal stenosis, metabolic disorders, severe gastrointestinal diseases and excessive iron content.

Contraindications

Contraindications to the appointment of Sorbifer are hypersensitivity and intolerance to the components of the drug, high iron content, bleeding and severe gastrointestinal diseases, renal and hepatic failure, peptic ulcer.

With caution, the drug is prescribed to patients after blood transfusion, with colitis and Crohn's disease.

Side effects of Sorbifer and reviews

According to the description and reviews, Sorbifer does not cause serious side effects.

In rare cases, when taking the drug, allergic reactions and disorders of the functioning of the gastrointestinal tract may appear - nausea, vomiting, constipation, urticaria, dermatitis, bronchospasm, diarrhea.

I drank it during pregnancy, there were no problems, I was recently discharged to raise hemoglobin and, oh, horror. Weakness, pressure dropped, she walked and staggered from the side, although there were no such problems with low hemoglobin. As a result, the stomach ached as if poisoned, and a terrible diarrhea began with vomiting. I won't drink it again.

Fatima

With my low hemoglobin, the period of pregnancy became unbearable: constant headaches, drowsiness, terrible condition of the nails, etc. I had to discuss with the doctor the need to take a drug with iron, which could quickly fill the iron deficiency and maintain it at a normal level. The most effective and approved remedy for expectant mothers... With my low hemoglobin, the period of pregnancy became unbearable: constant headaches, drowsiness, terrible condition of the nails, etc. I had to discuss with the doctor the need to take a drug with iron, which could quickly fill the iron deficiency and maintain it at a normal level.
The most effective and approved remedy for anemia for expectant mothers, as the doctor told me, is Sorbifer Durules. I started taking it in the second trimester, and also continued the vitamin complex for pregnant women with magnesium. It is on this point that I want to emphasize so that they do not make my mistake.
The fact is, Sorbifer Durules almost always causes a strong side effect in the form of nausea, but it can be avoided or minimized if you do not drink complexes with magnesium.
In general, the remedy really quickly normalizes the level of iron in the body, and you don’t have to worry about the risk of anemia. It should be taken 40 minutes before or after a meal, so that it is normally absorbed, and there will be no problems with iron content.

If the tablets irritate the stomach, then drink with Ameprazol. That's what my doctor told me. What I am doing. You will not regret. Be healthy.

Can anyone advise if after taking Sorbifer Durules there are abdominal pains, nausea, and you need to drink it ....

I don’t understand people, what’s the difference what kind of stool is from sorbifer? The drug is good, it raises hemoglobin well, there were no side effects from taking it. But for some, the color of the stool is important.

I passed a planned medical examination at work, and naturally passed general tests. The blood showed low hemoglobin and the therapist prescribed to drink Sorbifer one tablet twice a day. I didn’t like only the taste - the aftertaste of iron is directly felt, but you can’t refuse the effectiveness of this drug! It took a month to finish my... I passed a planned medical examination at work, and naturally passed general tests. The blood showed low hemoglobin and the therapist prescribed to drink Sorbifer one tablet twice a day. I didn’t like only the taste - the aftertaste of iron is directly felt, but you can’t refuse the effectiveness of this drug! It took a month to bring my indicators back to normal, now I take tests every six months and monitor the level of iron.

I drank sorbifer during lactation, according to the prescription of a gynecologist. Initially, I started taking one tablet twice a day, after two weeks I began to drink 2 tablets in the morning and one in the evening for the best effect. Hemoglobin in a month became 132, and was 110.

Thank God, I felt good during pregnancy and everything was in order with the tests, and when I fed my daughter with iron deficiency, I did not encounter an iron deficiency, but everything was not so simple. Apparently, due to overwork, I still had iron deficiency anemia and I began to drink Sorbifer, I saw how it was prescribed ... Thank God, I felt good during pregnancy and everything was in order with the tests, and when I fed my daughter with iron deficiency, I did not encounter an iron deficiency, but everything was not so simple. Apparently, due to overwork, I still had iron deficiency anemia and I began to drink Sorbifer, I saw how it was prescribed to girls in a consultation, so I bought it. A good remedy, I drank it for a month and my lethargy and irritability disappeared without a trace ... And the truth is that I haven’t taken tests for hemoglobin yet, not when.

In the middle of pregnancy, I drank Sorbifer, but the stool was dark from it and there were constipations, but my health improved, and the child received the necessary amount of iron. And what they say about the high cost of medicine, I think is nonsense. There are similar drugs for raising hemoglobin, but there are no analogues, because Sorbifer contains ascorbic acid and iron, ... In the middle of pregnancy, I drank Sorbifer, but the stool was dark from it and there were constipations, but my health improved, and the child received the necessary amount of iron. And what they say about the high cost of medicine, I think is nonsense. There are similar drugs for raising hemoglobin, but there are no analogues, because Sorbifer contains ascorbic acid and iron, it treats iron deficiency anemia, and not its other types. Therefore, I think that its quality justifies the price by 100.

And I was sick of Sorbifer for several days, but I didn’t cancel it because the doctor said that it’s better to drink the drug and give birth to a healthy baby. Gradually, the unpleasant symptoms disappeared, probably the body got used to the drug, although I noticed that if I took the medicine with food and not after, I felt quite normal .... And I was sick of Sorbifer for several days, but I didn’t cancel it because the doctor said that it’s better to drink the drug and give birth to a healthy baby. Gradually, the unpleasant symptoms disappeared, probably the body got used to the drug, although I noticed that if I took the medicine with food and not after, I felt quite normal. As for hemoglobin, I again went to the doctor, said that the tests were all good, but it’s better to finish the drug for prevention purposes.

To say that Sorbifer helped is to say nothing. Well, imagine how you feel when hemoglobin is around 77. She was pale like a toadstool, fainted, sleepy all the time, plus absolute apathy. I'm not talking about crawling home to the second floor, it was a daily feat. Of course, I had to drink the drug not ... To say that Sorbifer helped is to say nothing. Well, imagine how you feel when hemoglobin is around 77. She was pale like a toadstool, fainted, sleepy all the time, plus absolute apathy. I'm not talking about crawling home to the second floor, it was a daily feat. Of course, I had to drink the drug not for a month or two. I drank it longer, but with interruptions so that the body rested. Now hemoglobin is already more than a hundred, although there are strengths, the face has acquired a normal color, and the emotional state has noticeably improved.