Children are prone to various kinds of respiratory diseases. An important role is played by the choice of a remedy that copes with rhinitis, tearing of the eyes (with allergic reactions), which is necessarily suitable for children. One of these medications is Tizin Xylo Bio spray. This drug is approved for children after two years of age. Children can also be given regular Tizin for adults, but only after the age of six.

The drug has a number of advantages, is safe for young patients, does not cause side effects. Young parents should carefully study the instructions for the product, follow it impeccably. Consult with your pediatrician first, find out all aspects of taking the medication.

Pharmacological properties

Tizin is a synthetic drug aimed at treating eye diseases, ailments accompanied by swelling of the mucous membranes of the nose. The drug is approved for use in infectious and allergic pathologies of the nasopharynx. The tool has a vasoconstrictive medicine, has an anticongestive effect, constricts blood vessels in the nasal cavity, facilitates breathing with a nose in rhinitis.

After just a few minutes, the remedy begins to act, the effect lasts up to 8 hours, which implies less medication. To obtain a long-term positive effect, Tizin is used systematically, with constant use, the drug has a central sedative effect. That is why at night the medication continues to act, re-use becomes unnecessary. Choose the right form of medicine for the crumbs, start the course of treatment immediately.

Release form and composition of the drug

Tizin is produced in the form of a nasal spray of a transparent color with a specific faint odor, 0.05% and 0.1% are produced. Tizin drops are similar to a spray, they have only one type of dosage of the active ingredient - 0.1%. The product is packaged in a plastic bottle, the spray has a special spray nozzle, drops - a dosing spout.

Both forms of Tizin include the same active substance - xylometazoline hydrochloride. It is included in the list of the most necessary medicinal products to eliminate swelling of the nasal mucosa. Preparations based on it quickly constrict blood vessels, facilitate nasal breathing, and are actively used in pediatrics.

In addition to the main component, the drug includes the following components:

• sodium chloride. Acts as a solvent, because it is combined with many components of drugs;
• benzalkonium chloride. It has a bactericidal effect on various fungi, staphylococci, staphylococci, Pseudomonas aeruginosa, mold;
• disodium edetate. Helps to remove the active component of the drug, due to the ability to form ionic compounds with some metals;
• sodium dihydrogen phosphate dihydrate. It is used to normalize the secretory fluid of the mucous membranes to the optimal pH balance;
• disodium phosphate dihydrate. Includes all of the above effects, accelerates the action of the active ingredient, has a beneficial effect on the healing process;
• sorbitol. Performs a detoxifying role;
• purified water. Acts as a solvent for all existing components.

The combination of useful elements of the medicinal product has a complex effect, quickly facilitates nasal breathing, and copes with eye ailments.

Indications for use

Tizin is well tolerated by young patients, For safety reasons, please consult your pediatrician before use. The instruction to the medication recommends using Tizin to eliminate the following problems:

• acute (runny nose that accompanies acute respiratory infections or infectious diseases);
• hay fever (chronic allergic reaction caused by individual intolerance to pollen);
• (is an inflammation of the paranasal sinuses that has arisen against the background of untreated rhinitis, due to complex infectious ailments previously suffered by the child, for example, influenza with complications);
• , which is accompanied by swelling;
• the drug is prescribed as an addition to general therapy in an acute form, the disease often occurs in young children.

The variety of uses of the drug is due to the fact that the drug solves nasal problems, copes with eye diseases in children. It is important to strictly follow the instructions, do not exceed the indicated dosage.

Interesting to know! Tizin is used not only as a remedy, but also before surgery, during the diagnosis of diseases of the eyes (drops), nose (spray).

Contraindications

The drug is well tolerated in most cases, there are some contraindications, non-compliance with which has a sharp negative impact on the health of the child.

Tizin is forbidden to use in the following cases:

• for spray and drops with a dosage of the active substance - 0.1 reception is recommended for children after six years;
• for a spray of 0.5%, admission is allowed from the age of two;
• with increased sensitivity to individual components of the drug, if there are negative consequences, stop taking immediately, consult a doctor;
• it is not recommended to combine the drug with MAO inhibitors, other medicines that increase blood pressure;
• there are few reviews about the lactation period, but it's not worth the risk. Women who are breastfeeding should refrain or consult with their doctor before using Tizin;
• additional consultation is necessary for those children who have problems with the liver, kidneys, suffer from diabetes.

To obtain the desired result, treat the child under the close supervision of a doctor. Timely detection of side effects will save the baby from complications, help to quickly cope with the disease.

Possible side effects

Tizin for children is well tolerated, but there are some reviews of parents about the appearance of undesirable effects after using the medicinal product. It is important to know the side effects at the slightest deterioration in the condition of the baby, consult a doctor:

• paresthesia. The condition is characterized by a sudden sensation of tingling, crawling, numbness at the site of use of the medication;
• burning sensation, often a side effect refers to the mucous membranes of the nose, less often to the eyes;
• dryness of the mucous membranes of the nose (more often occurs against the background of uncontrolled, prolonged or frequent use of the drug);
• hypersecretion. The pathological process is first characterized by abundant discharge from the nasal cavity, over time they become thick with impurities of pus, there are signs of intoxication of the body;
• drug rhinitis is a constant runny nose that appears while taking a specific drug, manifests itself even a week after the end of the use of the spray;
• dry rhinitis. The condition is characterized by drying of the nasal mucosa, the formation of crusts on it, constant nasal congestion;
• increased eye fatigue, a feeling of constant dryness.

The medication has a number of contraindications and side effects; for safety reasons, parents are not recommended to violate the established rules, a specific dosage.

Instructions for use and dosage

In order for the effectiveness of the medicinal product to be high, it is necessary to follow certain guidelines. In the treatment of eye diseases, the instruction recommends using the drug 2-3 times a day, instill it in the baby directly into the conjunctival sac. The spray should be injected with a maximum of three doses into each nasal passage, it all depends on the age, weight and disease of the child.

For children under six years of age, it is not recommended to use the medication more than four times a day, the interval should be at least 4 hours. In order to avoid negative consequences, be sure to consult a specialist, strictly follow the dosage indicated by him.

Before using the spray, be sure to shake the bottle, press the sprayer several times until a normal "puff" is formed, only then insert the end of the bottle into the child's nasal cavity. Then press the desired number of times, hold the device vertically, it is forbidden to use the spray with the bottle in the downward or sideways position. For convenience, let the baby tilt his head back slightly.

On the page, learn about the methods of treating herpes sore throat in children.

An approximate course of treatment is no more than seven days, the best option is treatment for 4 days. The approximate dosage for children is as follows:

• Tizin at a dosage of 0.05% is prescribed one dose in each nasal passage up to two times a day. This aspect applies to children under six years of age;
• children from six to twelve years old are allowed Tizin at a dosage of 0.1%, one dose three times a day.

Drops are prescribed according to the same scheme, only a doctor deals with eye treatment, the exact dosage, the duration of treatment is also indicated by a children's oculist or pediatrician.

Cost and storage conditions

The price of Tizin Xylo Bio for children at a dosage of 0.05% is approximately 180 rubles per package, a similar remedy with a dosage of 0.1% is 10 rubles more expensive. The price of Tizin drops varies between 140-160 rubles per bottle, depending on the dosage of the active ingredient. The cost is also affected by the city of purchase, a specific pharmacy chain.

Drops and spray Tizin instruction recommends storing at a temperature not exceeding 25 degrees Celsius, the shelf life of medicinal products does not exceed 36 months. An open bottle is recommended to be stored for about three months, after this time the medication cannot be used.

Analogues of a medicinal product

The pharmacological industry produces many drugs that are similar in clinical effect to the drug. If for any reason Tizin did not suit your baby, replace it with another medicine. Analogues of the drug include:

• Knoxprey;
• Otrivin;
• Zirtrek;
• Nazol Baby;
• Nazik;
• Nasonex;
• No-Sol and others.

Before using any medicine, consult your doctor, read the instructions carefully.

Tizin for children shows excellent results, quickly copes with rhinitis, eye diseases of various etiologies. The universal therapeutic product is well tolerated by the children's body, rarely causes side effects. The main thing is to stick to the dosage, do not use the remedy often.

Many parents have appreciated the effectiveness of Tizin for babies, try it for yourself. The medicine perfectly copes with the task, gently eliminates the causes of the disease.

Tradename: Tyzine® (Tyzine®)

International non-proprietary name: tetrizoline

Dosage form: nasal drops; nasal drops for children

Compound

Active substance: tetrizoline hydrochloride.
1 ml of Tizin 0.1% for adults contains 1.0 mg of tetrizoline hydrochloride.
1 ml of Tizin 0.05% for children contains 0.5 mg of tetrizoline hydrochloride.
Excipients:
sorbitol solution 70% (non-crystallizing), hypromellose, benzyl alcohol, sodium citrate, perfume oil (No. 25768), benzalkonium chloride solution 17%, disodium edetate, concentrated hydrochloric acid 37%, macrogol glyceryl hydroxystearate (Cremophor 40), purified water.

Description: clear colorless or opalescent liquid.

Pharmacological properties

Pharmacotherapeutic group: anticongestive agent - vasoconstrictor (alpha-adrenergic agonist).

ATX code: R01AA06.

Pharmacodynamics

Tetrizoline belongs to the group of sympathomimetics and has a direct stimulating effect on the alpha-adrenergic receptors of the sympathetic nervous system. However, it has no or almost no effect on beta-adrenergic receptors. As a sympathomimetic amine, the drug has a vasoconstrictive and anti-edematous effect when it enters the nasal mucosa, which leads to narrowing of the small arterioles of the nasal passages, a decrease in swelling of the nasal mucosa and a decrease in secretion.
The vasoconstrictive effect and reduction of mucosal edema under the influence of tetrizoline begins approximately 1 minute after topical application of the drug and lasts 4-8 hours.

Pharmacokinetics

Indications for use

To reduce swelling of the nasal mucosa in patients suffering from rhinitis, pharyngitis, sinusitis, hay fever, as well as to reduce swelling of the nasal mucosa, if diagnostic and therapeutic measures are necessary.

Contraindications

• Hypersensitivity to any of the components of the drug;
• dry rhinitis;
• angle-closure glaucoma;
• Tizin 0.1% for adults is contraindicated in children under 6 years of age;
• Tizin 0.05% for children is contraindicated in children under 2 years of age.

Carefully

In patients with severe cardiovascular disease (eg, ischemic heart disease (CHD), arterial hypertension, arrhythmia, aneurysm, pheochromocytoma), with metabolic disorders (eg, hyperthyroidism, diabetes), and in patients taking MAO inhibitors or other drugs that increase blood pressure , Tizin can be used only after a careful comparison of the possible benefits and risks to the patient.

Pregnancy and lactation

Since there is a possibility of systemic side effects (mainly a vasoconstrictor effect), the use of the drug during pregnancy and lactation is possible only after a careful comparison of the possible benefit to the mother and the risk to the fetus (child).

Dosage and administration

Tizin nose drops 0.1% for adults
If there are no other prescriptions, then adults and children over 6 years of age are prescribed 2-4 drops of the drug in each nostril 3-5 times a day.

Tizin nose drops 0.05% for children
Unless otherwise prescribed, children aged 2 to 6 years are prescribed 2-3 drops of the drug in each nostril 3-4 times a day.

Tizin should be used no more than once every 4 hours.
As a rule, a more infrequent use of the drug is sufficient, since in most cases the drug has a long-term effect (often up to 8 hours). A single use of the drug at bedtime relieves nasal congestion throughout the night, but can cause insomnia due to the effect of tetrizoline on the central nervous system.
Tizin can be used for a short time. The duration of treatment should be no more than 5 days for adults and no more than 3 days for children. The drug can be re-administered only after a few days.

Side effect

Reactive hyperemia, burning sensation of the mucosa, chronic swelling of the nasal mucosa with prolonged use of the drug, sometimes a systemic effect is possible (palpitations, headaches, insomnia, tremors, weakness, sweating, increased blood pressure, nausea, allergic reactions).
Too frequent use or prolonged (more than 5-7 days) use of tetrizoline, as well as the use of the drug in high doses, can lead to a burning sensation and dryness of the nasal mucosa, as well as the development of reactive edema and drug-induced rhinitis.
Long-term use of imidazole derivatives can have a damaging effect on the mucosa, inhibiting the activity of the ciliated epithelium. Irreversible damage to the mucosa can lead to the development of dry rhinitis.

Overdose

The risk of developing systemic side effects is high in young children if the drug is ingested.
Excessive systemic absorption of alpha-sympathomimetic imidazole derivatives can lead to depression of the central nervous system, which is manifested by drowsiness, a decrease in body temperature, bradycardia, hypotension, apnea and coma.
The usual symptoms of overdose include dilated pupil, nausea, cyanosis, fever, convulsions, tachycardia, cardiac arrhythmia, cardiac arrest, hypertension, pulmonary edema, respiratory failure, mental disorders.
There is no known antidote for tetrizoline hydrochloride.
Treatment: administration of activated charcoal, gastric lavage, oxygen, as well as antipyretics and anticonvulsants if necessary. In order to lower blood pressure, phentolamine is prescribed 5 mg in saline IV slowly or 100 mg orally. Vasoconstrictor drugs are contraindicated in hypotension.

Influence on the ability to drive a car and work with mechanisms

With too long use of the drug or the use of doses exceeding those recommended, systemic cardiovascular effects may develop. Systemic side effects can lead to impaired ability to drive or use machines.

Interaction with other drugs

Combined use with monoamine oxidase inhibitors and tricyclic antidepressants can lead to an increase in blood pressure as a result of potentiation of the vasoconstrictor effect.

Release form

Nasal drops 0.1%; nasal drops for children 0.05%.
10 ml solution in a brown glass bottle with a plastic screw cap and a glass pipette with a rubber tip mounted in it. 1 bottle with instructions for use in a cardboard box.

Storage conditions

Store at a temperature not exceeding 25°C. Keep out of the reach of children.

Best before date

5 years.
Do not use the drug after the expiration date.

Terms of dispensing from pharmacies

Over the counter.

Manufacturer
"Heinrich McNasl. GmbH & Co. KG, Germany.
Pfizer group company.

Legal address: Heinrich Mack Nachf. GmbH & Co KG,
Heinrich-Mack-Str. 35, 89257, Illertissen, Germany
"Heinrich McNasl. GmbH & Co. KG,
Germany, Illertissen, 89257, Heinrich Mak Str. 35.

Representation in Russia(organization accepting claims):
Moscow office of Pfizer International LLC,
109147, Moscow, st. Taganskaya, 21.

medicinal product

Tizin ®

Tradename

Tizin ®

International non-proprietary name

Xylometazoline

Dosage form

Spray nasal dosed

Compound

1 ml of solution contains

active substance- xylometazoline hydrochloride 0.5 mg (0.05%) or 1.0 mg (0.1%); the amount of the active ingredient in one dose for 0.05% - 0.035 mg xylometazoline hydrochloride; for 0.1% - 0.14 mg xylometazoline hydrochloride

Excipients: benzalkonium chloride, sorbitol 70%, sodium chloride, sodium dihydrogen phosphate dihydrate, disodium hydrogen phosphate dihydrate, disodium edetate, purified water.

Description

Clear, colorless solution, odorless or with a slight characteristic odor.

Pharmacotherapeutic group

Anticongestants other nasal preparations for topical use.

Sympathomimetics. Xylometazoline.

ATX code R01AA07

Pharmacological properties

Pharmacokinetics

When applied topically, it is practically not absorbed, plasma concentrations are so small that they cannot be determined by modern analytical methods.

Pharmacodynamics

Xylometazoline (an imidazole derivative) is a sympathomimetic drug with alpha-adrenergic activity. It has a vasoconstrictive effect and reduces swelling of the mucous membrane.

The action usually begins within 5-10 minutes. The drug facilitates nasal breathing by reducing swelling and hyperemia of the mucous membrane, and also improves the discharge of secretions.

Indications for use

To reduce swelling of the mucous membrane of the nasopharynx and secretions in acute allergic rhinitis, acute respiratory infections with rhinitis, sinusitis, hay fever, otitis media .

Preparation of the patient for diagnostic manipulations in the nasal passages.

Dosage and administration

Intranasally.

0.05% spray for children from 2 to 6 years: 1 injection in each nasal passage 1-2 times a day.

0.1% spray for adults and children over 6 years of age: 1 injection in each nasal passage 2-3 times a day.

The dose depends on the individual sensitivity of the patient and the clinical effect. Should not be used more than 3 times a day.

The drug is used for no more than 5-7 days.

After completion of therapy, the drug can be re-administered only after a few days.

Remove protective cap. Before the first application, press the spray nozzle several times (Fig. 1) until a uniform cloud of "fog" appears. The bottle is ready for further use. When applying, press once (Fig. 2). The drug is inhaled through the nose. Keep the spray bottle upright if possible. Do not spray horizontally or downwards. After use, close the bottle with a cap.

Side effects

Often

With frequent or prolonged use, irritation or dryness of the nasal mucosa, arthrosis of the nasal mucosa, burning, sneezing, addiction, hypersecretion, chronic rhinitis are possible.

Infrequently

palpitations, cardiac arrhythmias, increased blood pressure

pressure

Nausea, vomiting

Allergic reaction

Very rarely

Headache

Contraindications

• hypersensitivity to the components of the drug
• concomitant use of monoamine oxidase (MAO) inhibitors, or other drugs that can cause an increase in blood pressure
• arterial hypertension
• tachycardia
• severe atherosclerosis
• glaucoma
• atrophic rhinitis
• surgical interventions on the meninges (in history)
• children's age up to 2 years (TIZIN ® for a dosage of 0.05%)
• children under 6 years of age (TIZIN ® for a dosage of 0.1%)

Carefully:

• IHD (angina pectoris), prostatic hyperplasia, thyrotoxicosis, diabetes mellitus, pheochromocytoma.

Drug Interactions

The simultaneous use of MAO inhibitors such as tranylcypromine or tricyclic antidepressants can lead to an increase in blood pressure due to the cardiovascular effects of these substances.

special instructions

Prolonged use and overdose of sympathomimetics that have a decongestant effect can lead to reactive hyperemia of the nasal mucosa.

The rebound phenomenon can cause airway obstruction, which leads to the fact that the patient begins to use the drug repeatedly or even permanently. This can lead to chronic swelling (drug-induced rhinitis), and eventually even to atrophy of the nasal mucosa (ozena).

In the case of chronic rhinitis, TIZIN ® 0.05% and 0.1% can only be used under medical supervision, given the risk of atrophy of the nasal mucosa.

TIZIN ® should not be used in the presence of hypersensitivity to benzalkonium chloride, which is part of the drug as a preservative.

Pregnancy and lactation

TIZIN ® should not be used during pregnancy, as the effects of this drug on the fetus have not been studied in adequate studies. The drug should not be used during breastfeeding, as it is not known whether the active substance is excreted in breast milk or not.

Features of the influence of the drug on the ability to drive a vehicle or potentially dangerous mechanisms

With prolonged treatment or the use of the drug TIZIN ® in higher doses, the possibility of its systemic effect on the cardiovascular system cannot be ruled out, which may impair the ability to drive and use machinery.

Overdose

Symptoms: Overdose or accidental ingestion of the drug inside can lead to the following symptoms: dilated pupils, nausea, vomiting, cyanosis, fever, spasms, tachycardia, cardiac arrhythmias, collapse, cardiac arrest, hypertension, pulmonary edema, respiratory failure, mental disorders.

In addition, the following symptoms may be observed: suppression of the function of the central nervous system, accompanied by drowsiness, a decrease in body temperature, bradycardia, shock-like hypotension, apnea and coma.

Table of contents [Show]

In this article, you can read the instructions for using the drug Tizin. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Tizin in their practice are presented. We kindly ask you to actively add your reviews about the drug: the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Tizin's analogues in the presence of existing structural analogues. Use for the treatment of the common cold in adults, children, as well as during pregnancy and lactation. The composition of the drug.

Tizin- sympathomimetic. When applied topically, it causes a vasoconstrictive effect, which develops after a few minutes and persists for a long time.

Tizin Xylo Bio is a vasoconstrictor drug for topical use in ENT practice. Xylometazoline (an imidazole derivative) is an alpha-adrenergic agonist that constricts the blood vessels of the nasal mucosa, eliminating edema and hyperemia of the mucosa. Facilitates nasal breathing in rhinitis. Hyaluronic acid, which is part of the preparation, has a moisturizing effect when used in nasal medicines due to the ability to maintain mucous membranes in a hydrated state and creates optimal conditions for recovery processes.

The action usually develops within 5-10 minutes.

Compound

Tetrizoline + excipients (Tizin).

Xylometazoline hydrochloride + excipients (Xylo and Xylo Bio).

Pharmacokinetics

When applied topically, systemic absorption is low.

Indications

• slight eye irritation;
• itching, swelling and hyperemia of the conjunctiva;
• burning, lacrimation, injection of the sclera due to chemical and physical factors (dust, cosmetics, swimming in chlorinated water, exposure to bright light);
• allergic conjunctivitis;
• to reduce swelling of the mucous membrane of the nasopharynx and secretions in acute allergic rhinitis, acute respiratory infections with rhinitis, sinusitis, hay fever, otitis media;
• preparation of patients for diagnostic manipulations in the nasal passages.

Release form

Drops in the nose 0.1%.

Nasal spray 0.05% and 0.1% (Tizin Xylo and Xylo Bio).

Instructions for use and method of use

Nasal spray

Tizin Xylo and Bio in the form of a nasal spray 0.05% is prescribed to children aged 2 to 6 years, 1 dose in each nasal passage 1-2 times a day.

Tizin Xylo and Bio in the form of a nasal spray 0.1% is prescribed for adults and children over 6 years old, 1 dose in each nasal passage 3 times a day.

The dose depends on the individual sensitivity of the patient and the clinical effect.

Do not use the drug for more than 5-7 days without a doctor's recommendation.

After completion of therapy, the drug can be re-administered only after a few days.

The duration of the drug in children is determined by the doctor.

Rules for the use of the drug

Remove protective cap. Before the first use, press the spray nozzle several times until a uniform cloud of "fog" appears. The bottle is ready to use. When applying, press 1 time. The drug is inhaled through the nose. Keep the spray bottle upright if possible. Do not spray horizontally or downwards. After use, the bottle should be closed with a cap.

Side effect

• transient mild nasal irritation (burning) in susceptible individuals;
• sneeze;
• increased swelling of the nasal mucosa (reactive hyperemia);
• headache;
• insomnia;
• visual impairment;
• fatigue and depression (with prolonged use in high doses);
• heartbeat;
• tachycardia;
• arrhythmia;
• increase in blood pressure.

Contraindications

• concomitant use of MAO inhibitors or other drugs that increase blood pressure;
• tachycardia;
• glaucoma;
• atrophic rhinitis;
• surgical interventions on the meninges (in history);
• thyrotoxicosis;
• patients with severe cardiovascular diseases (for example, coronary artery disease (including angina pectoris), tachycardia, arterial hypertension, severe atherosclerosis);
• patients with surgical interventions on the meninges in history;
• children's age up to 6 years (for nasal spray 0.1%);
• children's age up to 2 years (for nasal spray 0.05%);
• hypersensitivity to any of the components of the drug.

Use during pregnancy and lactation

Xylometazoline should not be used during pregnancy, because. effects on the fetus have not been studied in clinical studies.

The drug should not be used during breastfeeding, because. it is not known whether the active substance is excreted in breast milk.

special instructions

Prolonged use and overdose of sympathomimetics that have a decongestant effect can lead to reactive hyperemia of the nasal mucosa. As a result, there is difficulty in nasal breathing, which leads to the fact that the patient begins to use the drug repeatedly or even permanently. This can lead to chronic swelling (drug-induced rhinitis), and eventually even to atrophy of the nasal mucosa (ozena).

In milder cases, to improve the patient's condition, you can first stop the introduction of a sympathomimetic into one nasal passage, and after reducing complaints, continue to inject it into the other nasal passage in order to partially ensure nasal breathing.

The patient should be informed that if the medicinal product has become unusable or the expiration date has expired, then it should not be thrown into wastewater or into the street. It is necessary to place the drug in a bag and put it in a trash container. These measures will help protect the environment.

Influence on the ability to drive vehicles and control mechanisms

With prolonged treatment or the use of the drug in higher doses, the possibility of its systemic effect on the cardiovascular system cannot be ruled out. In such cases, the ability to drive and use machinery may be impaired.

drug interaction

The simultaneous use of MAO inhibitors such as tranylcypromine or tricyclic antidepressants can lead to an increase in blood pressure due to the cardiovascular effects of these substances.

Analogues of the drug Tizin

Structural analogues for the active substance:

• Berberyl N;
• Vizin;
• Vizin Classic;
• VizOptic;
• Montevizin;
• Octilia.

Analogues for the therapeutic effect (remedies for the treatment of the common cold):

• 4 Wei;
• Abisil;
• AquaMaris;
• Aqualor baby;
• Aqualor norms;
• Artromax;
• Aspirin Complex;
• Bioparox;
• Vibrocil;
• Galazolin;
• Glycodin;
• Grippostad Reno;
• GrippoFlu for colds and flu;
• Derinat;
• Children's Tylenol for colds;
• For the nose;
• Isofra;
• Insty;
• Influnet;
• Koldakt;
• Koldar;
• Coldrex MaxGripp;
• Corisalia;
• Xylene;
• xylometazoline;
• Xymelin;
• Libeksin Muko;
• Lordestin;
• Marimer;
• Mentoclar;
• Morenasal;
• Nazivin;
• Nazol;
• Knoxprey;
• Pinosol;
• Prostudox;
• Rinzasip with vitamin C;
• Rhinonorm;
• Rhinopront;
• Rinofluimucil;
• Romazulan;
• Sanorin;
• Snoop
• Suprastinex;
• Tizin Xylo;
• Tizin Xylo Bio;
• Toff plus;
• Umckalor;
• Farial;
• Farmazolin;
• Fervex spray from the common cold;
• Physiomer nasal spray;
• Fluifort;
• Fluditec;
• Flucoldex H;
• Fugentin;
• Humer;
• Erdomed;
• Erespal;
• Euphorbium.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases from which the corresponding drug helps and see the available analogues for the therapeutic effect.

In 1 ml. Tizin Xylo contains 0.5 mg. or 1 mg. (depending on the form of release of the drug) xylometazoline hydrochloride, as well as such excipients as: disodium edetate, sodium chloride and benzalkonium, disodium dihydrate and sodium hydrogen phosphate, water and sorbitol.

The drug is produced in vials of class III hydrolytic brown glass, with a nominal volume of 10 ml. For ease of use, the bottles are equipped with a specialized pull-off cap, and in addition, a dosing device.

Tizin Xylo with a concentration of 0.05% of the active substance is designed for approximately 140 doses, and a drug containing 0.1% xylometazoline- for 70 doses. Drops are a colorless solution that may have a slight characteristic odor.

The medicine has anticongestive, and besides, alpha-adrenomimetic properties.

Drops containing xylometazoline, which is a derivative imidazole refer to sympathomimetic drugs. Tizin Xylo has alpha-adrenergic properties and provides vasoconstrictor effect, thereby reducing swelling of mucous membranes. The drug improves the condition of the mucosa, reduces hyperemia, accelerates the discharge of secretions and reduces swelling after a maximum of 10 minutes after use.

Tizin Xylo is recommended for use in ORZ accompanied by rhinitis(including with an allergic form of the disease), with otitis media, as well as at sinusitis. In addition, drops are used at the preparatory stage for the upcoming diagnostic examination of patients.

• hypersensitivity;
• hypertension;
• tachycardia;
• atherosclerosis;
• atrophic rhinitis;
• glaucoma.

In addition, Tizin Xylo should not be used while taking MAO inhibitors, as well as drugs that affect the level blood pressure, at the risk of surgical intervention in the area of ​​the meninges (even in history). With extreme caution, drops should be used when thyrotoxicosis, hyperplasia, at diabetes mellitus, angina pectoris And fechoromocytoma.

Extremely rarely, when using Tizin Xylo, the following side effects may occur: burning and irritation of mucous membranes, hypersecretion, and paresthesia and sneezing, hyperemia in hypersensitive patients. With prolonged use of drops may develop drug rhinitis, insomnia, there are strong headache, and depression. In some cases, the use of the drug may be accompanied by visual disturbances, tachycardia, increased pressure and arrhythmia.

In accordance with the instructions for the spray, Tizin drops are used intranasally. Spray for children (active compound concentration 0.05%) aged 2 to 6 years is used one dose in each nostril no more than twice a day. Adults, as well as children from 6 years of age, can use the drug at a concentration of 0.1%, one dose in each nostril no more than three times a day.

In accordance with the instructions for Tizin Xylo Bio, this type of nasal drops is used according to the above scheme.

It should be noted that an overdose of the drug can occur only if the recommendations for the use and dosage of drops are not followed. In such cases, patients may experience symptoms such as: spasms, drowsiness, nausea, fever, fluctuations in body temperature, apnea, vomiting and dilated pupils, bradycardia, tachycardia, pulmonary edema, hypotension, arrhythmia, cardiac arrest or collapse, respiratory failure and psyche, coma.

Tizin Xylo must not be taken in conjunction with drugs that affect blood pressure, as well as with MAO inhibitors relating to tricyclic or tranylcypromine antidepressants.

OTC dispensing from pharmacies.

At temperatures up to 25 C, out of reach of children.

General shelf life - 3 years.

Drops should be taken under the supervision of a doctor in a chronic form rhinitis. The composition of the drug includes a preservative such as benzalkonium chloride which can cause allergic reactions. When used correctly, drops do not affect the ability to drive a car or potentially dangerous units and mechanisms, however, with prolonged use, Tizin Xylo may have a negative effect on the cardiovascular system of the body.

Brizolin, For the nose, Galazolin, Nazolin, Influrin, Xylometazoline, Xylen, Ximelin, Hippostad Rino, Asterisk NOZ, Farmazolin, Olint, Nosolin, Otrivin, Rinorus, Snoop, Espazolin, Rinonorm, Sanorin-Xylo, Rinomaris, Tizin Xylo BIO, Evkazolin AQUA.

Since specialists have not conducted scientific studies aimed at identifying the effect of this drug on the fetus during pregnancy Tizin Xylo is not recommended for use during this period of time. In addition, these drops should not be used in lactation period, because it is not known for certain whether the compounds that make up the drug penetrate into the child's body with mother's milk.

The manufacturer provides two forms of release of Tizin Xylo drops for children: from 2 to 6 years old - a dosage of 0.05%, older - 0.1%.

Patients using this drug, in most cases, give it a positive response, while noting the effectiveness of the drops and their speed. Reviews about Tizin Xylo Bio are also often good.

The price of the spray depends primarily on the form of release of nasal drops. As a rule, the average price of Tizin Xylo Bio (10 ml bottle) does not exceed 100 rubles.

Tizin Xylo BIO spray 0.05% 10 ml

Tizin Xylo spray 0.05% 10 ml 140 doses

Tizin Xylo nasal spray 0.1% 10ml

Tizin Xylo Bio 0.05% nasal spray 10ml

Tizin Xylo nasal spray 0.05% 10ml

Tizin Xylo Bio 0.1% nasal spray 10ml

Tizin xylo1

Tizine xyloPfizer P.G.M. (France)

Tizin Xylo spray 0.1% 10mlMcNeil

Tizin Xylo spray 0.1% 10mlMcNeil

Tizin, as described in the instructions for use, is recommended to be used to relieve painful symptoms in acute rhinitis and otolaryngological diseases, accompanied by rhinorrhea and difficulty in nasal breathing.

Tizin Xylo belongs to the pharmacological group of vasoconstrictors, a discharge of alpha-adrenomimetics, local action, widely applicable in otolaryngological practice. Available in two forms:

• Nasal drops.
• Spray nasal.

The principle of action is due to the ability of the active substances to constrict the vessels localized in the nasal cavity. According to medical experts, drops and spray have the following therapeutic properties:

• vasoconstrictor effect.
• Anti-edematous action.
• Elimination of hyperemia.
• Facilitate nasal breathing.
• Moisturizing the mucous membranes of the nose.
• Activation of recovery and regeneration processes.
• Elimination of rhinorrhea.

Thanks to hyaluronic acid, which is part of the drug, this nasal remedy acts gently and delicately, without overdrying or irritating the nasal mucosa. The medicine contributes to the normalization of pressure indicators in the auditory tubes, which can effectively prevent the development of otitis media.

It begins to act a few minutes after administration, and its therapeutic effect lasts for at least six hours. Despite the fact that the drug is characterized by an exclusively local effect, it should be used with extreme caution in small patients. This is due to the increased thinness and permeability of the children's nasal mucosa, which increases the absorption of active substances, and, consequently, the risk of adverse reactions.

What diseases will help?

• Manifestation of nasal allergic reactions.
• Diseases of viral and bacterial origin, accompanied by nasal congestion, rhinitis and problems with nasal breathing.
• Rhinitis of acute and vasomotor type.
• Pharyngitis.
• Sinusitis.
• Acute respiratory diseases.
• Otitis media.
• Hay fever (hay fever).

In addition, due to its pronounced vasoconstrictive and anti-edema action, Tizin drops are used by otolaryngologists in preparing the patient for diagnostic, therapeutic or surgical measures. In chronic rhinitis, the remedy is used extremely carefully and under the strict supervision of a specialist, in order to avoid the development of atrophic changes and possible drug dependence.

Medical specialists categorically do not recommend using Tizin Xylo if the patient has the following health problems:

• Atrophic rhinitis.
• The presence of angle-closure glaucoma and other severe ophthalmic diseases.
• Elevated blood pressure.
• Hypertonic disease.
• Arterial hypertension.
• Severe course of atherosclerosis.
• Accelerated heart contractions.
• Angina.
• Severe diseases of the cardiovascular system.
• Individual intolerance and hypersensitivity to active substances.
• Previous surgical interventions in the area of ​​the meninges.
• Disturbances in the functioning of the thyroid gland.
• Thyrotoxicosis and other diseases of the endocrine system.
• Pheochromocytoma.
• coronary asthma.
• Dry inflammatory processes localized in the area of ​​the mucous membranes of the nose, accompanied by the formation of crusts.
• Enlargement of the prostate.
• Elevated intraocular pressure.

Tizin is contraindicated for the treatment of young patients under the age of two. During pregnancy, there are also restrictions on the use of this medication. Like other nasal vasoconstrictors, this drug is strictly prohibited during the first trimester of pregnancy (to avoid the threat of miscarriage). At other times, future and breastfeeding mothers can use Tizin, but only as prescribed by the attending physician, in minimal dosages and for a limited time!

What side effects can provoke?

During a therapeutic course with the use of Tizin Xylo, patients may experience the following adverse reactions:

• Irritation and burning sensation localized in the nasal cavity.
• The development of reactive hyperemia.
• Violation of visual function.
• Increase in arterial and intraocular pressure.
• Increased fatigue.
• Headache.
• Sleep disorders.
• Heart rhythm disturbances (arrhythmia).
• Increased heart rate (tachycardia).
• depressive states.
• Attacks of dizziness.
• Nosebleeds.
• Paroxysmal sneezing.

Quite rarely, patients begin to show allergic reactions, which are expressed in itching, skin rashes, angioedema.

In most cases, the manifestation of the above side effects is due to the presence of contraindications in the patient or prolonged, improper use. If any adverse reactions occur, you should immediately stop using the product and seek professional advice from a qualified specialist!

An acute overdose can develop with the internal use of the drug or against the background of its systematic use, with a permanent excess of the recommended doses (young children are especially susceptible to this). For an overdose, the following painful symptoms are characteristic:

• Arrhythmia.
• Nausea and bouts of vomiting.
• Cyanosis.
• Feverish state.
• Spasms and convulsive syndrome.
• Respiratory dysfunction.
• Pulmonary edema.
• Increased blood pressure with the threat of a hypertensive crisis.
• Circulatory collapse.

In addition, the active substances of Tizin in high concentrations (this is possible with prolonged use of the drug in high dosages) have an overwhelming effect on the patient's central nervous system, which leads to the following clinical signs:

• Slow heart rate (bradycardia).
• Apnea.
• Decrease in body temperature.
• Hypotonic crisis.
• Increased sleepiness.
• Shock state.
• hallucinations.
• shock-like hypotension.

This condition is dangerous due to sudden cardiac arrest and the patient falling into a deep coma. If there are signs of an overdose with Tizin, the patient should be given a gastric lavage and qualified medical specialists should be called in, who will prescribe the necessary symptomatic treatment to the victim. In case of severe overdose, the patient may need to be hospitalized.

Prolonged use of Tizin, as well as other vasoconstrictor nasal agents, is fraught with the manifestation of atrophic changes in the nasal mucosa, the development of chronic swelling, hyperemia, and also rhinitis of a medical nature. With frequent and prolonged use, the effectiveness of the drug is significantly reduced, so Tizin should be used carefully and moderately, strictly observing the duration of the therapeutic course recommended by the attending physician!

With the manifestation of signs of drug dependence on Tizin, it is necessary to gradually reduce the dosage of the drug. To begin with, it is recommended to inject Tizin into only one of the nasal passages.

Small patients, starting from the age of two, should be instilled with 2-3 drops of the drug, from one to three times during the day. An individual consultation with your doctor will help determine the optimal daily dosage for a particular clinical case.

The time intervals between instillations of Tizin should be at least four hours. To increase the effectiveness of the drug, immediately before its administration, the nasal cavity is recommended to be thoroughly cleaned of accumulated secretions of a mucous nature. This can be done by blowing your nose or rinsing the nasal cavity.

The optimal duration of the therapeutic course with Tizin is from three to five days. If there are certain indications, the specialist can extend the treatment for a few more days, making a mandatory break for a period of 2-3 days.

In order to ensure the safest and most effective treatment, medical professionals suggest following these recommendations:

1. Avoid prolonged use of Tizin and reduce the daily dosage if signs of improvement appear.
2. Use with caution before going to bed, as this can provoke the development of insomnia.
3. Refrain from taking tricyclic antidepressants and drugs that increase blood pressure during the therapeutic course.
4. Avoid work that requires increased concentration and attention, since the active substances of Tizin can affect the central nervous system and temporarily impair visual function.

The duration of saving Tizin is four years. It is recommended to store the product in a place protected from moisture and direct sunlight, and also inaccessible to small children. It is strictly forbidden to freeze the drops!

Tizin Xylo is an effective and popular nasal remedy, the action of which is aimed at facilitating the processes of nasal breathing and the patient's condition with acute rhinitis of various origins. Use the remedy should be moderate and only to provide temporary, symptomatic relief! Long and uncontrolled use of Tizin leads to addiction, the development of drug-induced rhinitis, systemic overdose and other dangerous complications!

Tizin is a well-known remedy in the form of a nasal spray, designed to eliminate the common cold and various forms of rhinitis. Not all patients are suitable for this medication. To figure out in which cases the medicine is prescribed, the instructions for using the spray in the nose Tizin will help.

The drug is produced in the form of a spray with a volume of 10 ml. The composition includes the main component of xylometazoline hydrochloride, as well as auxiliary ingredients. The concentration of the active substance can be 0.05% and 0.1%.

The vial of dark glass contains a clear liquid with a specific odor. The bottle with the solution is equipped with a special spray nozzle, with which the substance is dosed.

The drug, belonging to the category of alpha-agonists, is intended for irrigation of the nasal passages.

Due to its properties to reduce swelling and relieve inflammation from the mucous surfaces, the medicine facilitates breathing through the nose and helps to eliminate purulent mucus.

Nasal spray Tizin Xylo refers to symptomatic therapy and is not able to eliminate the cause of rhinitis. The vasoconstrictive effect of the drug can be explained by the action of xylometazoline: this component affects the epithelial cells located in the nose and secreting sputum.

The use of the drug contributes to:

• elimination of edema;
• decrease in secretion;
• restoration of breathing through the nose;
• improving the general condition of the patient.

The therapeutic effect occurs within 5 minutes, and can persist for a long time. Local use of the drug virtually eliminates its absorption into the circulatory system.

• sinusitis, sinusitis;
• allergic and vasomotor rhinitis;
• inflammation of the mucous surfaces of the pharynx;
• inflammatory processes of the middle ear;
• hay fever;
• rhinorrhea.

In addition, the doctor may prescribe a medicine during the preparation of the patient for various diagnostic procedures and therapeutic manipulations.

A vasoconstrictor medication is often used for serious pathologies of the upper respiratory system. Tizin with sinus successfully relieves swelling and reduces excessive pressure in the nasal cavity. Most often, the spray is prescribed in the preparatory period before the puncture of the maxillary sinuses.

Despite the fact that the active substance of the drug acts locally, a small amount of it is able to penetrate into the circulatory system. It is this property that should be taken into account when using the spray during pregnancy.

Tizin for pregnant women can be prescribed if the probable threat to the development of the fetus does not outweigh the possible benefit.

At the moment, it has not been clarified whether xylometazoline is able to penetrate into breast milk. Due to this the substance is not recommended for use during lactation.

It is necessary to use the drug in childhood in a reduced dose - 0.05%. In this concentration, it is approved for use by babies from 2 years old. Tizin Xylo 0.1%, as well as Bio, are prescribed for children from 6 years of age.

Before purchasing drops, you must first see a pediatrician who will prescribe the necessary course of treatment and select the appropriate dosage.

Nasal drops Tizin Xylo are prohibited under the following pathological conditions:

• undergone surgery on the brain;
• the early age of children under two years old - for a concentration of 0.05%, under 6 years old - for 0.1%;
• cardiopalmus;
• high blood pressure;
• cholesterol deposits on the vessels;
• increased intraocular pressure;
• rhinitis with mucosal atrophy;
• various hormonal diseases;
• nasal polyps.

Caution must be observed in patients with cardiovascular disease, diabetes, prostate adenoma.

In addition, the drug must not be used in conjunction with monoamine oxidase inhibitors and other drugs that increase blood pressure.

Most often, drops are tolerated by patients quite easily. However, if a person has an individual intolerance to xylometazoline, side effects may occur:

• increased nasal discharge, as well as frequent sneezing;
• mucosal atrophy;
• itching and burning in the nostrils;
• formation of dependence and addiction to the remedy;
• swelling of mucous surfaces;
• the appearance of nosebleeds;
• development of drug-induced rhinitis.

These negative effects can occur at the end of therapy, even after 1 week.

Prolonged use of the drug is often the cause of irreversible changes and dryness of the mucous membranes.

Very rarely, patients experience:

• pain symptoms in the head;
• sleep disturbance;
• increased fatigue;
• depressive state.

Other undesirable consequences can also be heart palpitations, arrhythmia, increased pressure, visual disturbances.

To avoid negative manifestations, do not use the drug for more than 7 days, as well as independently increase the recommended dosage.

Too long a course of treatment often leads to an overdose, expressed in increased negative effects. In this situation, the patient needs to cancel the medication and consult with the attending physician. If necessary, the specialist will prescribe symptomatic therapy.

The use of a spray in increased doses often provokes hyperemia of the mucous surfaces.. In addition, an overdose is the cause of the deterioration of the cardiovascular system. In this case, the patient may experience:

• convulsive syndrome;
• nausea;
• feverish state;
• pupil dilation;
• cyanosis of the skin;
• swelling of the pulmonary system;
• mental disorder;
• disruption of the heart.

Spray Tizin is intended for spraying into the nasal cavity. One press of the vial corresponds to a single dose of the substance.

Before the first use it is necessary to prepare a vial. To do this, press on the nozzle. When using the spray bottle, keep it strictly in an upright position.

The agent is instilled into the nose, slightly tilting the head back. After the procedure, the bottle is closed with a protective cap:

• Nose drops for children are used at a concentration of 0.05%. At the age of 2 to 6 years, it is allowed to perform one irrigation of each sinus 1-2 times a day.
• Spray 0.1% is recommended for adults and children over 6 years old, 1-2 injections three times a day.

Drops have a long-term effect, so they do not require regular use.

The dose is set individually by the attending physician. In childhood, the drug should not be used for more than 3 days. The duration of treatment for adults should not exceed 5-7 days.

At the end of treatment, the drug is allowed to be taken again after a few days.

If there is no positive dynamics, or the patient's condition worsens, it is necessary to immediately consult with a medical professional.

It is worth noting that the use of drops before going to bed can completely eliminate nasal congestion, but can lead to insomnia.

Spray Tizin Xylo is not used in conjunction with MAO inhibitor medications, as well as antidepressants. This combination negatively affects blood pressure.

Besides, do not use other nasal sprays with a vasoconstrictor effect simultaneously with Tizin: the likelihood of developing negative consequences in this case increases significantly.

Drops can be easily bought at any pharmacy without a prescription. Store the medication out of the reach of children and in a dark place, at a temperature not exceeding 25 degrees. Shelf life - 5 years.

In the treatment of chronic rhinitis with Tizin, the risk of atrophic changes in the mucosa increases.. That is why it must be used under the supervision of a specialist. This disease requires the alternation of nasal drops, while the other drug should not contain xylometazoline.

The medicine can provoke a deterioration in visual abilities. In this regard, during therapy, it is necessary to refrain from activities associated with increased attention and reaction, work with complex mechanisms, as well as driving vehicles.

Before instillation of the drug, the patient should clean the nasal passages from accumulated mucous secretions.

At present, there is no data on the effect of the drug with a dosage of 0.05% on children under 2 years of age. It is for this reason that it is not recommended to treat babies with a spray without first consulting a pediatrician.

In pharmacy chains, Tizin Xylo 0.05% nasal drops can be purchased at a price of 106 rubles, 0.1% - at 113 rubles, Bio with a moisturizing component is sold at an average cost of 183 rubles.

Is it necessary to treat nasal congestion in children? Chronic runny nose can lead to oxygen starvation and malnutrition of brain cells.. And constant inflammation in the nasal cavity depresses the immune system. Subsequently, this can affect the normal development of the baby, as well as provoke serious complications. That is why doctors recommend getting rid of mucopurulent discharge from the nose in a timely manner, and Tizin can help with this.

Even a common cold in babies can scare a young mother. The child sneezes, it is difficult for him to breathe, he is naughty. Spray Tizin is a great way to deal with childhood malaise. It quickly relieves unpleasant symptoms and makes breathing easier for colds and allergies.

A review of the drug will help parents understand the intricacies of using Tizin for various types of rhinitis in children.

Tizin helps to quickly eliminate nasal congestion, restores irritated mucous membranes.

Tizin Xylo and Tizin Xylo Bio 0.05 are designed taking into account the characteristics of the child's body and are recommended for use from 2 to 6 years. Tizin Allergy is a remedy for allergic rhinitis, the instructions for use indicate that it can be used from 6 years of age.

• The main active ingredient in children Tizin Xylo- xylometazoline hydrochloride. This vasoconstrictor drug reduces swelling of the nasal mucosa. Thanks to this property, within 5-10 minutes after application, the child becomes easier to breathe. It also contributes to a better discharge of secretions that stagnate in the nose and create a feeling of congestion.
• The composition of the spray Tizin Kislo Bio, in addition to xylometazoline hydrochloride, silver is included, which prevents the spread of pathogenic bacteria and moisturizes the mucous membranes of the nose.

Tizin Xylo BIO contains silver ions that neutralize pathogenic bacteria.

• Tizin Alergi effective for runny nose caused by allergies. The main component is levocabastine hydrochloride. The remedy relieves itching in the nose, sneezing and reduces the amount of mucus.

Manufacturers, release forms and prices

Sprays are made in Europe. Tizin Xylo comes to Russia from France, and Xylo Bio comes from the capital of Spain. The manufacturer of Tizin for allergies is the American company Johnson & Johnson.

All sprays are available in the form of a solution in glass or polyethylene bottles equipped with a spray and cap.

Instructions for use are always included in the carton box.

The tool can be freely bought at any pharmacy. Average price:

• Tizin Xylo (140 doses) - 100 r;
• Tizin Xylo Bio (140 doses) - 210 r;
• Tizin Allergy (100 doses) - 170 r.

Spray Allergy quickly helps to eliminate the symptoms of allergies in the nasal cavity.

Indications for use

Use Xylo and Xylo Bio if:

• the child has a common acute respiratory disease, accompanied by a runny nose;
• the doctor diagnosed rhinitis - an inflammatory process of the nasal mucosa;
• the baby has sinusitis or inflammation of the middle ear - the medicine will facilitate the exit of the departments;
• assigned to the diagnosis of the nasal passages.

The main indication for Tizin Alergi is a runny nose, nasal congestion and intense mucus discharge due to allergies.

According to the doctor, Tizin is useful for children only when:

• it is difficult for the child to breathe not only through the nose, but also through the mouth;
• the temperature has risen;
• otitis was diagnosed.

The medicine will help with otitis media.

How to use the spray Tizin

Read the instructions that come with each package carefully. When treating a child, compliance with the rules and dosages is especially important, because the baby's body has not yet fully adapted to the surrounding conditions. The spray is more convenient than other dosage forms: 1-2 sprays are enough. This saves time, and for children it turns into an exciting game - because sometimes it is impossible to persuade the baby to throw back his head and sit quietly while instilling drops into his nose.

Application procedure

In order to use Tizin correctly:

1. open cap;
2. press the sprayer several times to make a small cloud appear;
3. carefully insert the sprayer into the nostril;
4. press it as many times as prescribed by the doctor;
5. be sure to keep the bottle upright;
6. when spraying, do not point the dispenser down or horizontally.

Hold the bottle upright!

Dosages

• Spray with an active ingredient concentration of 0.05 is intended for babies from 2 to 6 years old
• When treating children older than 6 years of age, doctors recommend using Tizin 0.1 three times a day.
• With allergies, Tizin Allergy can only be used if the child is 6 years old. Wherein:
  • use the remedy 2 times a day if the allergy is not very strong, and 3-4 times if the symptoms cause severe inconvenience;
  • do 2 sprays in each nostril.

The duration of treatment for the common cold in children is always determined by the doctor. Usually it's a week. If the symptoms do not go away, then seek advice from the clinic.

Download instructions for use for Tizin Xylo, Xylo Bio, Alerji →

Contraindications and side effects

Tizin Xylo and Xylo Bio 0.05 should not be used:

• if the child has not reached the age of two;
• with intolerance to the components of the agent;
• with severe pathologies of the heart;
• after brain surgery
• if the inflammation of the nasal mucosa is chronic and leads to their atrophy.

Do not use Tizin Allergy if the child is under 6 years old (an allergic reaction to the drug may occur) and with kidney disease.

Side effects are extremely rare. They appear as:

• burning and swelling of the nasal mucosa;
• increased sneezing;
• headaches;
• sleep disorders.

Some parents report drowsiness in children after taking the drug.

Long-term use of the drug can cause dry rhinitis. It manifests itself in the form of inflammation of the mucous membrane and the formation of crusts on the nose.

Side effects in the treatment of Tizin Allergy occur very rarely. Their symptoms:

• nausea;
• cough;
• dizziness;
• nosebleeds;
• a sore throat;
• high fatigue.

The tool should not be taken orally and the dosage should not be exceeded. If this happens, then there is nausea, vomiting, drowsiness, disruption of the heart. If these signs appear, seek medical attention immediately.

Reviews of mothers and doctors

The effectiveness of the product is confirmed by reviews of buyers and doctors. Here's what moms and pediatricians say:

Marina, mother of 4-year-old Anton:

“Recently, my son got sick. Some kind of virus with fever, stuffy nose. At first I washed it with saline, but it did not help, it was difficult for the baby to breathe. I decided to try Tizin. He acted immediately - the vessels narrowed, and the mucus began to depart. The child blew his nose and breathed normally. Very convenient to use - just sprayed 2 times, that's enough. It costs a little, only 100 rubles. Great remedy for stuffy nose!

The spray facilitates the passage of mucus.

Olesya, mother of 3-year-old Ira:

“I buy Tizin for my daughter. It's inexpensive and helps a lot. I like that it is easy to use, the dispenser just needs to be inserted into the child's nose. Even if it spins, everything turns out very quickly. After the first time, Irishka almost immediately got rid of the itching in her nose, and the sneezing stopped. It is also important for me that the girl tolerates the medicine well - no side effects, no allergies. In addition, I read the reviews and finally convinced myself that I was right. As a result, she settled on Tizina.

Julia, pediatrician:

“I often prescribe the drug for young children. It constricts blood vessels well, does not allow inflammation to spread. I like the quick effect, the kids literally begin to breathe freely in 5 minutes. I use it for my own child and for myself. The only negative is that you can get used to it, so I recommend treating it for no longer than 5 days. ”

The medicine is prescribed for children from 2 years of age.

What can replace Tizin

Tizin can be replaced by analogues based on the same active substance.

There are also products with a similar effect, but with other active ingredients in the composition.

An analogue of Tizin - Nazivin - a savior from the common cold.

Tizin is a popular remedy that is suitable for young children from 2 years old. Its main advantage is ease of use and speed of action. A runny nose often seems like a harmless symptom, and many moms start treating it on their own. But if the disease intensifies, and its symptoms do not go away, consult a doctor. Only a pediatrician will select the most effective treatment regimen.

Anna Dakian

Tizin is a topical vasoconstrictor drug, based on synthetic materials, used to treat eye diseases of various etiologies, and also used in ENT practice to treat pathologies accompanied by swelling of the nasal mucosa.

Tizin spray is allowed for OTC sale in pharmacies. The drug belongs to the category of medicines that are indicated for both allergic and infectious diseases of the eyes and nasopharynx.

Tizin is a colorless nasal solution that does not have a pronounced odor, available in two forms - spray and drops. Depending on the amount of active substance, the drug is divided into adult and children. Tizin for adults should be used with caution during pregnancy or breastfeeding. Children's Tizin can not be used by children, under 2 years old.

Tizin analogues are: Allergin, Vizin, Ditadrin, Octilia.

When using Tizin as a nasal spray, it is important to strictly follow the dosage prescribed by the doctor. It is also not recommended to extend the allowable course of treatment, which is 5 days.

Compound

1. Xylometazoline hydrochloride.
2. Sodium chloride.
3. Denatria edetat.
4. Purified water.
5. Benzalkonium chloride.
6. Disodium hydrophosphate dihydrate.
7. Sodium dihydrophosphate dihydrate.
8. Sorbitol.

The mechanism of action of the drug Tizin

Thanks to the active ingredient of the solution, an alpha-agonist, Tizin has a vasoconstrictive and anticongestive effect on the mucous membrane of the nasopharynx or cornea. Just a few minutes after the drug solution enters the body, a vasoconstrictor effect develops, which persists for a long time. 6-8 hours.

To achieve maximum benefit, it is necessary to systematically use the drug, as it has a sedative effect on the central stimulus.

Indications for the use of Tizin:

• Conjunctival inflammation of the eyes of various etiologies.
• Secondary eye hyperemia due to severe allergic reaction.
• Conjunctivitis against the background of catarrhal disease - acute respiratory infections, acute respiratory viral infections, influenza.
• Rhinitis.
• Sinusitis.
• Pharyngitis.
• Otitis media.
• Hay fever.
• Pollinosis.
• Diagnosis of eye diseases.
• Preparation for surgery.

How to apply spray Tizin for children

The dosage of the drug is determined by the age of the patient and the clinical symptoms of the disease. The duration of the course of treatment for the child is determined by the doctor, self-medication is not allowed.

In the treatment of eye diseases, it is recommended to use Tizin 2-3 times a day making sure that a drop of the solution falls into the conjunctival sac. For intranasal use, the recommended dose is 2-3 drops in each sinus. For children under 6 years of age, it is recommended to use Tizin spray no more than 4 times in 24 hours, making sure that the time interval between the use of the spray was at least 3 hours.

Contraindications to the use of Tizin

• Individual intolerance to the ingredients that make up the spray.
• For a nasal spray with an active ingredient concentration of 0.1% - children under 6 years of age.
• For a nasal spray with an active ingredient concentration of 0.05% - children under 2 years of age.
• Taking medications that affect blood pressure.
• Reception of MAO inhibitors.
• Atrophic variety of rhinitis.
• Surgical operations on the meninges in history.
• Tachycardia.
• Glaucoma.
• Diseases of the heart and blood vessels, accompanied by severe hypertension and impaired
  heart rate.

Adverse reactions of the body

• Itching and burning around the eyes.
• Reactive hyperemia.
• Hypersecretion causing sneezing.
• Dry rhinitis, characterized by dryness of the nasal mucosa, which develops against the background of prolonged use of the spray.
• Increased intraocular pressure.
• Midiriasis.
• Cyanosis, fever, cardiac arrhythmia, collapse (side effects observed very rarely).

Storage conditions and price of the drug Tizin

The drug must be stored out of the reach of children, the temperature in which should not exceed 25 degrees. Shelf life 2 years. After opening, the bottle should be tightly closed with a cap and stored for no more than a year. The price of the drug fluctuates from 80 to 110 rubles for a bottle.

Reviews of people who used Tizin spray

1. Natalya, 38 years old: “When I took my son to kindergarten, he immediately began to get sick often - colds, ARVI flowed bronchitis and tracheitis. Against the background of weakened immunity, the nose was constantly blocked. At the pharmacy, the pharmacist advised Tizin spray - a nasal solution in a compact bottle with a convenient dispenser. Literally after a couple of days of use, I noticed that it became easier for my son to breathe, the snot became transparent. The spray works effectively, but at the same time it is injected into the sinuses absolutely painlessly.
2. Olga, 40 years old: “My daughter suffers from allergies, which can overtake her almost anywhere. It manifests itself in a profuse runny nose, the nose stops breathing, the eyes turn red. For emergency help, we always have Tizin spray at home, which is effective for nasal congestion. It almost instantly facilitates nasal breathing, neutralizing discomfort.
3. Pavel, 32 years old: “For the first time we tried Tizin spray when my son was three years old and he became seriously ill. The nose did not breathe for several days, the baby practically did not sleep. Tizin spray with a convenient dispenser quickly relieves swelling of the nasal mucosa and facilitates nasal breathing. After a single dose, the runny nose disappeared all night. The only drawback is that you cannot use it often and for a long time, as these are vasoconstrictor drops.

Tizin xylo - a drug for topical use in otolaryngology, with anticongestive action, constricts blood vessels and reduces blood flow in them; alpha-agonist.

Release form and composition

The dosage form of Tizin xylo is a dosed nasal spray: a clear liquid, colorless and odorless, or with a slight characteristic odor (10 ml of the drug in a vial, 1 vial in a cardboard box).

Composition per 1 ml of solution:

• active substance: xylometazoline hydrochloride - 0.5 or 1 mg (1 spray dose contains 0.035 or 0.14 mg of the active substance, respectively);
• auxiliary components: benzalkonium chloride, sorbitol, sodium chloride, sodium dihydrogen phosphate dihydrate, disodium hydrogen phosphate dihydrate, disodium edetate, purified water.

Pharmacological properties

Pharmacodynamics

Xylometazoline is an imidazole derivative, a sympathomimetic with alpha-adrenergic activity. Reduces swelling and hyperemia of the nasal mucosa, has a vasoconstrictive effect, improves mucus discharge, facilitating nasal breathing. Its action develops within 5-10 minutes after injection.

Pharmacokinetics

When applied topically, the drug is practically not absorbed, and its plasma concentration remains below the detection limit.

Indications for use

• acute allergic rhinitis;
• rhinitis accompanying acute respiratory infections;
• sinusitis;
• hay fever;
• otitis media;
• preparation for diagnostic measures in the nasal passages.

Contraindications

Absolute contraindications:

• arterial hypertension;
• severe atherosclerosis;
• tachycardia;
• angle-closure glaucoma;
• atrophic rhinitis;
• surgical operations on the meninges (in history);
• joint use with monoamine oxidase inhibitors (MAO) and other drugs that can increase blood pressure (BP);
• age up to 2 years (for a dosage of 0.05%);
• age up to 6 years (for a dosage of 0.1%);
• lactation period;
• increased sensitivity to the components of the drug.

Relative contraindications: coronary heart disease, angina pectoris, prostatic hyperplasia, thyrotoxicosis, diabetes mellitus, pheochromocytoma, pregnancy, hypersensitivity to adrenomimetics (accompanied by insomnia and dizziness).

Instructions for use Tizin xylo: method and dosage

The drug is administered by intranasal injection.

Assign a spray of 0.05% Tizin xylo for children from 2 to 6 years old: 1 dose in each nasal passage 1-2 times a day.

Spray 0.1% is indicated for children over 6 years of age and adults: 1 dose in each nasal passage 3 times a day.

The duration of the use of Tizin Xylo should not exceed 7 days, unless otherwise recommended by a doctor. Conducting a second course is possible not earlier than a few days after the end of the previous one.

Side effects

According to the instructions, Tizin Xylo can lead to the development of the following local undesirable effects: burning in the nose, sneezing, increased secretion, irritation and swelling of the nasal mucosa.

Long-term and frequent use can cause the development of dryness of the mucous membrane and reactive stagnation with the development of drug-induced rhinitis, up to irreversible damage to the mucous membrane (dry rhinitis), and this effect can develop even 5-7 days after drug withdrawal. Also, long-term use of Tizin xylo in high doses can cause headache, fatigue, insomnia and depression.

Systemic side effects of Tizin Xylo: in isolated cases - palpitations, arrhythmias, tachycardia, increased blood pressure, visual impairment.

Overdose

Symptoms of an overdose of Tyzin Xylo: dilated pupils, nausea, vomiting, cyanosis, spasms, fever, arrhythmias, tachycardia, collapse, hypertension, suppression of the central nervous system (drowsiness, decrease in body temperature, bradycardia, shock-like hypotension, apnea, coma), mental disorders , cardiac arrest, pulmonary edema, respiratory failure.

Recommended treatment: gastric lavage, activated charcoal, artificial respiration with oxygen. To reduce blood pressure, phentolamine is indicated at a dose of 5 mg with a solution of sodium chloride intravenously slowly, or 100 mg by mouth. Vasopressor drugs are contraindicated. The use of anticonvulsants and antipyretics is allowed.

special instructions

Long-term use of high doses of Tizin xylo can lead to reactive hyperemia of the nasal mucosa and drug-induced rhinitis, up to atrophy of the nasal mucosa. In this regard, in chronic rhinitis, the drug should be used only under the supervision of a physician.

Influence on the ability to drive vehicles and complex mechanisms

With prolonged use of the drug in high doses, systemic side effects from the cardiovascular system may develop. In this case, care should be taken when driving vehicles and other complex mechanisms that require quick psychomotor reactions.

Use during pregnancy and lactation

Data on the use of Tizin Xylo in pregnant women are limited, and therefore the spray is prescribed only when the expected benefit to the mother outweighs the possible risk to the fetus.

There is no data on the ability of xylometazoline to penetrate into breast milk. The use of the drug is contraindicated during lactation.

Application in childhood

The appointment of Tizin Xylo is contraindicated for children under 2 years of age. For the treatment of children from 2 to 6 years old, a 0.05% solution should be used, according to the recommendations for use. Children over 6 years of age are shown a 0.1% solution.

Use in the elderly

drug interaction

Co-administration of Tizin xylo with MAO inhibitors and tricyclic antidepressants can lead to a pronounced increase in blood pressure.

Analogues of Tizin xylo are Galazolin, Grippostad Rhino, Fornos, Dr. Theiss Rhinotheiss, Asterisk NOZ, Influrin, Xylen, Xylometazoline, Xymelin, Nosolin, Otrivin, Rinomaris, Rinonorm, Rhinorus, Rhinostop, Sanorin-xylo, Snoop, Suprima-NOZ, Tizin, Tizin xylo BIO, Evkazolin Aqua, Espazolin, etc.

Terms and conditions of storage

Store at a temperature not exceeding 25 °C. Keep away from children.

Shelf life - 3 years.

Terms of dispensing from pharmacies

Released without a prescription.