In what cases should Dioxidin be used and can it be used without a doctor’s prescription? Dioxidin for a runny nose: properties, dosage and rules of use Dioxidin solution analogues

...
Pharmacology: Pharmacological action - broad-spectrum antibacterial, bactericidal. Active against Proteus vulgaris, Pseudomonas aeruginosa, Escherichia coli, Shigella dysenteria spp., Shigella flexneri, Shigella boydii, Shigella sonnei, Salmonella spp., Klebsiella pneumoniae (Friedlander's bacillus), Staphylococcus spp., Streptococcus spp., pathogenic anaerobes (Clostridium perfringens ). Acts on strains of bacteria resistant to other chemotherapy drugs, including antibiotics.
When administered intravenously, it penetrates well and quickly into organs and tissues; therapeutic concentrations in the blood are maintained for 4–6 hours. Cmax is achieved 1–2 hours after a single administration. When applied topically, it is partially absorbed and does not have a local irritating effect. Practically not subject to metabolism. Excreted by the kidneys. Does not accumulate with repeated administrations.
Promotes faster cleansing of the wound surface, stimulates reparative regeneration, marginal epithelization, and has a beneficial effect on the course of the wound process.
Experimental studies have demonstrated the presence of teratogenic, embryotoxic and mutagenic effects.

Application: Intracavitary: purulent-inflammatory processes of various localization: purulent pleurisy, pleural empyema, lung abscess, peritonitis, cystitis, purulent wounds with deep cavities, incl. soft tissue abscess, phlegmon, postoperative wounds of the urinary and biliary tract, prevention of infectious complications after bladder catheterization, purulent mastitis, abscesses and phlegmon of the maxillofacial area.
IV: severe septic conditions (including in patients with burn disease), purulent meningitis, purulent-inflammatory processes with symptoms of generalized infection.
Locally: wound and burn infections, superficial and deep purulent wounds of various locations, long-term non-healing wounds and trophic ulcers, soft tissue phlegmon, infected burns, purulent wounds with osteomyelitis, purulent processes in the pelvic tissue, mastitis, pustular skin diseases.

Contraindications: Hypersensitivity, adrenal insufficiency (including history), age under 18 years.

Restrictions on use: Renal failure.

Use during pregnancy and breastfeeding: Contraindicated.

Side effects: With intracavitary and intravenous administration - headache, chills, increased body temperature, dyspeptic disorders (nausea, vomiting, diarrhea), convulsive muscle twitching, allergic reactions; when applied topically - itching, periwound dermatitis.

Overdose: Symptoms: dystrophy, acute adrenal insufficiency.

Method of administration and dosage: Intracavitary, intravenous drip, local. Used only in adults, in a hospital setting (according to the method described in detail in the Instructions for Use). The duration of treatment is determined individually and depends on the severity of the condition, the effectiveness and tolerability of the drug.
Intracavitary: 1% solution is administered through a drainage tube, catheter or syringe (usually from 10 to 50 ml). The maximum daily dose is 0.7 g (70 ml of 1% solution). Before a course of intracavitary use, the tolerability of the drug is assessed by introducing 10 ml of a 1% solution into the cavity. If there are no side effects within 3–6 hours (dizziness, chills, increased body temperature), a course of treatment is started. Otherwise, the drug is not prescribed.
IV drip: infused with a 0.1–0.2% solution (obtained by diluting a 0.5% solution in a 5% glucose solution or in an isotonic sodium chloride solution), the highest single dose is 300 mg. Daily dose - 600–900 mg.
Locally: a thin layer of ointment is applied to the affected area of ​​the skin (the wound is first cleaned of purulent-necrotic masses) or napkins covered with a layer of ointment 2–3 cm thick are applied to the wound (an average of up to 30 g of ointment is used per bandage, for large burn surfaces the amount of ointment should not exceed 100 g per day) or soaked in a 1% solution; deep wounds are tamponed (after soaking tampons with ointment) or irrigated with a 0.5% solution; in the form of an aerosol - evenly applied to the wound surface (foam layer thickness 1–1.5 cm), no more than 5 balloons per day (2.5 g of the drug). The procedure is carried out daily or every other day, depending on the condition of the wound and the course of the wound process.

Precautions: Use under strict medical supervision. Prescribed only for severe forms of infectious diseases or when other antibacterial drugs are ineffective.
When administered intravenously, the drug is characterized by a narrow therapeutic range (strict monitoring of compliance with recommended doses is required). To prevent adverse reactions, it is recommended to use it in combination with antihistamines and calcium supplements. If adverse reactions occur, the dose should be reduced, antihistamines should be prescribed, and if necessary, the drug should be discontinued.
In case of renal failure, the dose is reduced

Trade names of drugs with the active ingredient Hydroxymethylquinoxalindioxyde
Dixin
Dioxidine ointment 5%
Dioxidine injection solution 1%

Dioxidine
Dioxidine solution for injection 0.5%
Hindiox

http://www.rlsnet.ru/opisdrug/MNNDescr.php?mnnid=72

The occurrence of a runny nose at any time of the year leads to the inability to normally inhale the necessary oxygen. Some people in this situation do not use medications, believing that the body should cope with the inflammation on its own. Others immediately begin to act, instilling possible drops.

It is necessary to approach treatment correctly, because an untreated disease of the nasal passages threatens to develop into serious complications, including the formation of congestion in the maxillary sinuses. For the treatment of nasal congestion and strong secretion of internal secretion, doctors recommend Dioxidin.

In addition, Dioxidin effectively copes with bacterial strains that develop immunity to other drugs.

The active substance of Dioxidin is hydroxymethylquinoxylin dioxide.This ingredient is presented in the form of a crystalline powder, without a specific odor, with a yellow-green tint. The auxiliary substance is purified liquid.

The medicine is released in 3 forms:

• 1% solution for local and intracavitary use
• 0.5% essence for intravenous, local and intracavitary use
• ointment in tube 5%

Any type of drug is used for therapy. When the substance is instilled into the nasal passages, an unpleasant, bitter taste is felt.

For what kind of runny nose can it be used?

Dioxidin belongs to the group of drugs with a fairly wide spectrum of effects. Its therapy covers several types of runny nose, both seasonal and caused by pathogenic bacteria.

There are the following areas in which the drug has a positive effect and eliminates nasal congestion:

• Viral
• Traumatic
• Medication
• Hypertrophic
• Atrophic

Due to the fact that Dioxidin is an aggressive drug, it is prescribed to relieve nasal congestion of various types only when absolutely necessary. This situation occurs during the inflammatory process in the acute phase.

The most commonly used is a 0.5% solution. It is administered only in a hospital setting with the help of medical personnel. It is prohibited to administer the drug yourself. In its pure form, the medication is prescribed extremely rarely; usually the drug must be combined with other medications:

1. Adrenaline – for a vasoconstrictor effect.
2. Hydrocortisone – as an antiallergic agent.
3. Water for infusion and saline solution - for diluting a highly concentrated solution, as well as for irrigation of the mucous membrane in the nasal passages.

Simultaneously with treatment with Dioxidin, it is necessary to use traditional methods of eliminating congestion and swelling of the nasal passages. This is done by warming the sinuses and rinsing with a weak saline solution.

Dioxidin is practically not prescribed for children for treatment unless its use is absolutely necessary.

It is prohibited to treat a child on your own; instructions for use and dosage should be recommended by a doctor familiar with the history of the disease.

Additionally, when prescribing treatment, it is worth monitoring the air temperature in the room where the patient is most often located. Periodically you need to ventilate the room and monitor the humidity. This is necessary so as not to provoke additional irritation of the nasopharyngeal mucosa with dry and hot air.

How does the medicine act on the nasal mucosa?

Dioxidin is a drug aimed at combating pathogenic bacteria that enter the nasal cavity. Once in the sinuses, the active component has a disinfecting effect. This effect provokes an improvement in the patient’s general condition during treatment for a cold.

The active substance acts purposefully against harmful microorganisms, being absorbed into the cell, it destroys the membrane from the inside. Thanks to this process, the number of bacteria decreases, blocking the possibility of their further development.

If severe rhinitis occurs in a child, the drug is instilled into the nose. In some situations, discomfort manifests itself as severe pain. In this case, it is necessary to inhale the drug diluted with saline using a nebulizer.

Using an inhaler, you can successfully treat a runny nose complicated by a bacterial infection of the respiratory system.

This development of inflammation leads to pneumonia, pleurisy, tracheitis, and bronchitis. In such a scenario, doctors strongly recommend resorting to inhalation with Dioxidin.

Thanks to these methods of influence, the pyogenic process is eliminated. The therapeutic process that occurs with the help of inhalations with Dioxidin is particularly significant and effective when other drugs against pathogenic bacteria could not show an effect at a sufficient level.

Dosage and rules of use

The pharmacy sells ampoules with different contents of the medicinal substance - 0.5% and 1%. One bottle contains 10 mg of an effective product. To instill into the nasal passages, you must use a fresh ampoule each time; throw away used ones once and do not store them.

But in practice, 1 bottle is used during the day. This norm is enough for 3 doses: in the morning, at lunchtime and before going to bed. The opened bottle must be stored in the refrigerator, on its door. The top of the capsule must be closed with a cotton pad.

If ampoules with 0.5% substance are used, then they should not be pre-diluted with purified water. This solution is instilled into the nasal passages without prior preparation. Before inserting into the sinuses, 1% essence must be diluted with distilled water or saline in a ratio of 1 to 1.

The medicine can be used as injections intravenously or intramuscularly, but for therapy and strong secretion of internal secretion, treatment is carried out by instillation into the nasal passages.

If the inflammatory process develops into sinusitis, then the drug is administered using the intracavitary method.

To introduce Dioxidin into the nasal cavity, you need to open the ampoule and use a pipette to draw up the required volume of the product. For adults, no more than 3 drops are needed in each nostril at a time. When treating children, 1-2 drops should be administered into each nasal passage 2-3 times a day.

The duration of treatment and the frequency of administration of the drug are recommended by the doctor individually for each patient based on the course of the disease and the severity of the inflammatory process.

You can learn more about how to properly treat a runny nose from the video:

How to treat green snot in a baby

In order for the product to have a better effect on pathogenic bacteria and the mucous membrane, it is recommended to rinse the sinuses with saline before the procedure. For these purposes, you should use Marimer, Aqua Maris or Quix.

If necessary, you can prepare this product yourself at home. The resulting drug is injected 1 ml into each nostril. After washing, you should blow your nose thoroughly. After 3-5 minutes you can use Dioxidin.

The duration of treatment is controlled by the inflammatory process, but in most cases does not exceed more than 7 days. If therapy is carried out systematically, not forgetting to instill instillations on time, then pathogenic bacteria will die soon. Symptoms of a runny nose are eliminated within 3-4 days after the start of therapeutic treatment.

Dioxidin for runny nose during pregnancy and breastfeeding

The pharmacological mechanism of action is very strong and toxic for the expectant mother, as well as for women breastfeeding an infant.

Dioxidin is usually not used for treatment during pregnancy and breastfeeding. This is due to the fact that when the drug is administered, the active substance is able to penetrate the systemic circulation and be easily transported through the circulatory system to the developing fetus. Such an impact can become an impetus for the development of embryogenesis and negatively affect the development of the fetal neural tube.

The product also has a negative effect on the newborn. Once in the nasal passages, the main substance is absorbed into the mucous membrane, entering the bloodstream. During the production of breast milk, the drug easily overcomes physiological barriers and enters the baby's developing body. This influence has a negative impact on the child’s well-being. PTherefore, the use of the drug Dioxidin is prohibited during pregnancy and breastfeeding.

To whom and when is Dioxidin contraindicated?

Before you start using Dioxidin, you need to familiarize yourself with the contraindications. Incorrect administration and the presence of a prohibition on administration can contribute to the development of negative side effects.

The drug is prohibited for use in the following situations:

• Changes in normal kidney or liver function.
• Individual intolerance to the active substance or other components of the drug, causing allergic reactions.
• When high blood pressure is detected.
• With excessive dryness of the nasal mucosa.
• Children's age up to 12 years.
• If bleeding from the nose is detected.
• During pregnancy and lactation period.

The drug can be used in patients with chronic renal failure. But any exposure should be carried out only under the supervision of the attending physician or medical personnel.

Although the contraindications include childhood, many pediatricians resort to its use in serious situations. So, for the treatment of one-year-old children and older, you can use the medicine in a dosage diluted as 1:2.

The use of a drug in this case is possible only if other medications have not shown a positive effect upon exposure.

Can it cause side effects?

If the patient does not comply with the prescribed dosage or does not adhere to the administration standards, as well as in the presence of contraindications, side effects may occur.

The following signs of illness may occur:

• Skin rash and road rash.
• Problems with the digestive organs.
• Diarrhea.
• Increased heart rate.
• Emergence.
• Reduced ability to fight the mucous membrane with pathogenic microorganisms (addiction to the drug).
• Attacks of vomiting and severe nausea.
• Increased body temperature.
• Severe chills.
• Transition of the acute phase of nasal congestion into a chronic course.
• Changes in the functioning of the heart muscle.
• Head pain and dizziness.

Such consequences usually occur during the initial use of the drug. Identification of adverse reactions should be a signal to stop using drops to treat nasal congestion.If the patient has frequent allergic reactions, it is necessary to undergo allergy testing before administering the medicine. To do this, you must first apply 1 drop to the mucous membrane of the nasal passages. Wait 6-8 hours, if there is no reaction, then you can use Dioxidin.

In some cases, the formation of a negative state is a consequence of an incorrectly selected volume of injected solution.

If a dosage exceeding the normal dose is administered incorrectly, accidentally or deliberately, signs of overdose may develop. In such a situation, signs of dysfunction of the adrenal glands often appear, and acute adrenal insufficiency develops. If what is happening is detected, it is necessary to cancel treatment and resort to therapeutic effects with hormones.

After cancellation, it is recommended to see your doctor for diagnosis. The doctor will be able to identify the cause of the consequences and prescribe effective symptomatic treatment. In some situations, you have to resort to searching for substitute drugs.

What can replace it?

If an overdose occurs, as well as if contraindications or allergic reactions are detected during testing, the doctor decides to abandon Dioxidin and use other means of similar effects.

It is prohibited to select similar medications on your own. Otherwise, incorrectly chosen means to eliminate pathogenic bacteria from the nasal passages can lead to the development of consequences or deterioration in human health.

The following are the most suitable analogues of Dioxidin in terms of the spectrum of action and active substance:

• Fosfomycin
• 5-NOK
• Nitroxoline
• Kirin
• Zyvox
• Galenophyllipt
• Dioxicol
• Monural
• Ristomycin Sulfate
• Amizolid

The dosage and rules for using the selected medication instead of the original are prescribed by the doctor. This is done based on the severity of the disease.

Thus, Dioxidin is a drug that effectively copes with pathogenic microorganisms that enter the nasal passages and develop there. The medication is prescribed in difficult situations when other drugs cannot cope with the treatment. The main thing is to adhere to the prescribed dosage and recommendations of the treating doctor. If side effects are detected, the medication should be discontinued and consult a doctor.

In this article you can read the instructions for use of the drug Dioxidine. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Dioxidin in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Dioxidine in the presence of existing structural analogues. Use for the treatment of wounds and ulcers, sinusitis and boils, as well as inhalations in adults, children, as well as during pregnancy and lactation.

Dioxidine- a broad-spectrum antibacterial drug from the group of quinoxaline derivatives, has chemotherapeutic activity against infections caused by Proteus vulgaris, dysentery bacillus, Klebsiella, Pseudomonas aeruginosa, salmonella, staphylococci, streptococci, pathogenic anaerobes (including pathogens of gas gangrene), acts on strains of bacteria resistant to other chemotherapy drugs, including antibiotics.

The development of drug resistance in bacteria is possible. When administered intravenously, it is characterized by a small therapeutic width, and therefore strict adherence to the recommended doses is necessary. Treatment of burn and purulent-necrotic wounds promotes faster cleansing of the wound surface, stimulates reparative regeneration and marginal epithelization, and has a beneficial effect on the course of the wound process.

Pharmacokinetics

When applied topically, it is partially absorbed from the wound or burn surface and excreted by the kidneys.

Indications

• purulent bacterial infections caused by sensitive microflora when other chemotherapeutic agents are ineffective or poorly tolerated.

External use

• superficial and deep wounds of various locations;
• long-term non-healing wounds and trophic ulcers;
• soft tissue phlegmon;
• infected burns;
• purulent wounds with osteomyelitis.

Intracavitary administration

• purulent processes in the chest and abdominal cavity;
• for purulent pleurisy, pleural empyema, lung abscesses, peritonitis, cystitis, wounds with deep purulent cavities (soft tissue abscesses, pelvic cellulitis, postoperative wounds of the urinary and biliary tract, purulent mastitis).

Release forms

Solution in ampoules for inhalation and local, as well as intracavitary use (in the nose) 5 mg/ml and 1%.

Ointment for external use 5%.

Solution for intravenous administration 0.5%.

Instructions for use and usage diagrams

Dioxidin is prescribed in a hospital setting. Apply externally, intracavity.

Dioxidin 1% solution cannot be used for intravenous administration due to the instability of the solution when stored at low temperatures.

External use

Apply 0.1-1% solutions of Dioxidin. To obtain 0.1-0.2% solutions, ampoule solutions of the drug are diluted to the required concentration with sterile isotonic sodium chloride solution or water for injection.

To treat superficial infected purulent wounds, wipes moistened with a 0.5-1% solution of dioxidine are applied to the wound. Deep wounds after treatment are loosely tamponed with tampons moistened with a 1% solution of dioxidine, and if there is a drainage tube, 20 to 100 ml of a 0.5% solution of the drug is injected into the cavity.

For the treatment of deep purulent wounds with osteomyelitis (wounds of the hand, foot), use 0.5-1% solutions of the drug in the form of baths or carry out a special treatment of the wound with a solution of the drug for 15-20 minutes (injection of the solution into the wound for this period), followed by application of bandages with 1% dioxidine solution.

Dioxidin in the form of 0.1-0.5% solutions can be used to prevent infection after surgery. According to indications (patients with osteomyelitis) and if well tolerated, treatment can be carried out daily for 1.5-2 months.

Intracavitary administration

Depending on its size, 10-50 ml of a 1% dioxidine solution is injected into the purulent cavity per day. Dioxidine solution is injected into the cavity through a catheter, drainage tube or syringe.

The maximum daily dose for administration into the cavities is 70 ml of a 1% solution.

The drug is usually administered into the cavity once a day. According to indications, it is possible to administer a daily dose in two doses. If well tolerated and indicated, the drug can be administered daily for 3 weeks or more. If necessary, repeat courses are carried out after 1-1.5 months.

Side effect

• headache;
• chills;
• rising temperatures;
• dyspeptic disorders;
• convulsive muscle contractions;
• allergic reactions;
• photosensitizing effect (appearance of pigmented spots on the body when exposed to sunlight);
• periwound dermatitis (for external use).

Contraindications

• adrenal insufficiency (including history);
• pregnancy;
• lactation period;
• childhood;
• hypersensitivity to dioxidine.

Use during pregnancy and breastfeeding

Contraindicated during pregnancy and lactation.

special instructions

Dioxidin is prescribed only to adults. Before starting the course of treatment, a drug tolerance test is carried out, for which 10 ml of a 1% solution is injected into the cavities. If there are no side effects within 3-6 hours (dizziness, chills, increased body temperature), a course of treatment is started.

Dioxidin is prescribed only for severe forms of infectious diseases or when other antibacterial drugs are ineffective, incl. cephalosporins 2-4 generations, fluoroquinolones, carbapenems.

In case of chronic renal failure, the dose is reduced.

If pigment spots appear, increase the duration of administration of a single dose to 1.5-2 hours, reduce the dose, prescribe antihistamines or discontinue Dioxidin.

If Dioxidin crystals fall out in ampoules with a solution during storage (at temperatures below 15°C), they are dissolved by heating the ampoules in a boiling water bath while shaking until the crystals are completely dissolved (transparent solution). If, when cooled to 36-38°C, the crystals do not fall out again, the drug is suitable for use.

Analogs of the drug Dioxidin

Structural analogues of the active substance:

• Hydroxymethylquinoxyline dioxide;
• Dioxysept;
• Diquinoxide;
• Urotravenol.

If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.

Dioxidin is an antibacterial drug with a wide spectrum of action; it has an antibacterial and bactericidal effect on various pathogens - staphylococci, Pseudomonas aeruginosa, pathogenic anaerobes and some strains of bacteria that are resistant to other antibiotics.

The drug is available in the form of a solution intended for intracavitary and external use. The solution has a concentration of 1% and is available in 10 ml transparent glass ampoules, in cardboard packs with detailed instructions. The contents of the ampoule are sterile; the medicine may have a yellowish or greenish tint.

Active ingredient: Hydroxymethylquinoxaline dioxide.

The active ingredient Dioxidin effectively relieves purulent-inflammatory processes caused by Klebsiella, Salmonella, staphylococci, dysentery bacillus, Proteus vulgaris, Pseudomonas aeruginosa, pathogenic anaerobes and streptococci.

The use of Dioxidin ampoules speeds up the process of healing and cleansing of wound surfaces. In addition, when using the medication, reparative regeneration is activated.

Release form

The drug is produced in the form of a solution and ointment for external use.

• Dioxidine in ampoules of 0.5% and 1% solution. For local and intracavitary use. 10 ml and 20 ml in an ampoule, 10 pieces per package;
• Dioxidin ointment for external use 5% in tubes of 25 mg, 30 mg, 30 mg, 50 mg, 60 mg, 100 mg.

Indications for use

What does Dioxidin help with? According to the instructions, the drug is prescribed in the following cases:

• purulent bacterial infections caused by sensitive microflora when other chemotherapeutic agents are ineffective or poorly tolerated.

External use

• superficial and deep wounds of various locations;
• long-term non-healing wounds and trophic ulcers;
• soft tissue phlegmon;
• infected burns;
• purulent wounds with osteomyelitis.

Intracavitary administration

• purulent processes in the chest and abdominal cavity;
• for purulent pleurisy, pleural empyema, lung abscesses, peritonitis, cystitis, wounds with deep purulent cavities (soft tissue abscesses, pelvic cellulitis, postoperative wounds of the urinary and biliary tract, purulent mastitis).

Intravenously

• septic conditions (including in patients with burn disease);
• purulent meningitis;
• purulent-inflammatory processes with generalization symptoms.

Instructions for use Dioksidin (ampoules\ointment), dosage

Dioxidin ointment is intended exclusively for topical use. According to the instructions, the drug is applied to the affected area in a thin layer - 1 time per day. The course of treatment is up to 3 weeks.

Dioxidin in ampoules

Ampoules are intended for external or intracavitary use. As a rule, the drug is prescribed in a hospital setting. Before you start using the solution, you must do a tolerance test. If there are no side effects, the drug can be used for treatment within 4 hours.

According to the instructions for use, a 0.1-1% solution of Dioxidin is used for external use. To obtain a 0.1-0.2% solution, the ampoule must be diluted to the required concentration with a sterile isotonic sodium chloride solution.

To treat purulent and infected superficial wounds, it is necessary to apply napkins soaked in a 0.5-1% solution of the drug to the wound. After treatment, deep wounds are tamponed with tampons moistened with a 1% solution.

To treat deep wounds with osteomyelitis, make baths from a 0.5-1% solution of the drug, or treat the wound surface with the solution for 15-20 minutes, followed by applying a bandage to the wound soaked in a 1% solution of the drug.

A 0.5-1% solution of the drug is used to prevent infections in the postoperative period.

Treatment with Dioxidin can be carried out daily for 1.5-2 months.

For intracavitary administration, Dioxidin solution is injected into the purulent cavity using a syringe, tube or catheter. The maximum daily dosage is 70 ml of a 1% solution.

As a rule, it is administered once a day, but twice a day is also allowed according to indications. Treatment continues for 3 weeks.

Dioxidin in the nose is used for suspected allergic or vasomotor rhinitis, or when there is reason to suspect sinusitis. Place a few drops in each nostril several times. Drops reduce treatment time, prevent complications, and do not dry out the nasal mucosa.

Solution for intravenous drip administration

The drug is diluted with 0.9% isotonic sodium chloride solution or 5% dextrose solution to a concentration of 0.1-0.2%.

The daily dose is administered in 3-4 doses (fractional administration) or once, at a rate of 60-80 drops/min for 30 minutes.

• For chronic purulent processes in the lungs - daily dose of 500-600 mg (100-120 ml of 0.5% solution).
• In the treatment of purulent urinary tract infection - daily dose of 200-400 mg (40-80 ml of 0.5% solution).
• For severe septic conditions, the daily dose is 600-900 mg (divided into 3-4 doses).
• For purulent meningitis, the daily dose is 600-700 mg (20-140 ml of 0.5% solution).

Dioxidine in the ear

Dioxidin solution is prescribed to patients as an independent medicine or as part of complex therapy for purulent otitis and the spread of the pathological process to the Eustachian tube.

In a hospital setting, the ear cavity is washed with a solution of the drug, after which a cotton or gauze turunda is inserted into the ear for 20-30 minutes.

Side effects

The instructions warn about the possibility of developing the following side effects when prescribing Dioxidin:

• temperature increase.
• headache.
• chills.
• convulsive muscle contractions.
• various manifestations of allergic reactions (skin rashes, itching and burning, redness of the skin).
• vomiting or nausea.

When used externally, the development of periwound dermatitis is possible. In some patients, pigment spots appeared on the skin after using the drug. In such cases, reduce the dosage, increase the time of administration of a single dosage, and prescribe antiallergic drugs. If such measures do not lead to the disappearance of side effects, then you should stop using Dioxidin.

Contraindications

It is contraindicated to prescribe Dioxidin ampoules in the following cases:

• individual intolerance to the drug;
• period of pregnancy and breastfeeding;
• adrenal insufficiency;
• severe renal dysfunction, acute renal failure;
• children up to 12 years of age.

Overdose

With prolonged use of the solution intravenously or intracavitarily, overdose symptoms may develop - suppression of renal function and disruption of the functioning of vital organs.

If too large doses of the drug are accidentally administered orally, the patient should remain under the supervision of specialists with monitoring of important vital parameters. If necessary, symptomatic treatment is carried out.

If allergic reactions develop, antihistamines are prescribed, the dosage is reduced or therapy is stopped completely.

Dioxidin analogues, price in pharmacies

If necessary, you can replace Dioxidin with an analogue for therapeutic action - these are the following drugs:

1. Galenophyllipt,
2. Hexamethylenetetramine,
3. Zyvox,
4. Sangviritrin,
5. Urophosphabol,
6. Zenix,
7. Amizolid,
8. Dioxicol,
9. Quinoxidine.

By ATX code:

• Viumksidin,
• Galenophyllipt,
• Imbakt,
• Kalceks,
• Urotravenol.

When choosing analogues, it is important to understand that the instructions for use of Dioxidin in ampoules, price and reviews do not apply to drugs with similar effects. It is important to consult a doctor and not change the drug yourself.

Price in Russian pharmacies: Dioxidin 10 mg/ml solution 5 ml 10 ampoules - from 216 rubles, 1% solution 10 ml 3 ampoules - from 240 rubles, you can buy 1 ampoule of 0.5% solution 5 ml from 42 rubles, according to 593 pharmacies.

Store out of reach of children, protected from light at a temperature of +18...+25 °C. Shelf life – 2 years.

Dispensing conditions from pharmacies are by prescription.