Veroshpiron duration of use. Veroshpiron tablets: instructions for use. How to take: before or after meals

Diuretics are one of the components of medical therapy that helps people fight heart disease, urinary tract and liver diseases. One of these drugs can be called Veroshpiron. Instructions for use, tablets for what and to whom - you need to know all this so that the drug does not cause adverse reactions.

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The pharmacological action of the drug is a potassium-sparing diuretic. Veroshpiron is used for both treatment and prevention purposes. The drug is often included in the combination treatment of hypertension. It also helps reduce swelling in various diseases of the heart, liver, and kidneys.

The Latin name of the drug, which must be indicated by the doctor in the prescription, is Verospiron. The official trade name is Veroshpiron. The international ATX code is C03DA01. The basic active substance is spironolactone. The shelf life of the drug is 5 years.

Features of the composition

The drug is produced either in the form of tablets or capsules. Capsules are produced in 50 and 100 mg of spironolactone, while the tablet may contain only 25 mg of the active substance. If we describe the composition of the capsule, it will include spironolactone - 50 or 100 mg. Auxiliary components are:

• sodium lauryl sulfate;
• magnesium stearate;
• starch;
• lactose.

The gelatin base itself contains coloring agents, titanium dioxide and gelatin. The drug in capsule form is easier to take for patients who have problems with swallowing function. In appearance, the contents of the capsule resemble a white powder-like mixture. The body of the gelatin capsule (50 mg) is white with a yellow cap. The 100 mg capsule has a richer orange cap and a yellow body.

The tablets have a characteristic odor, round or oval shape, and white color. Veroshpiron tablet form contains 25 mg of spironolactone.

One package contains 20 tablets or 30 capsules. Analogues of the drug are Spironolactone Sandoz, Eplepres, Inspra, Diuver (Torasemide and Veroshpiron). The radar price for one package of the drug in 25 mg tablets (20 tablets) is from 90 rubles.

Effect of the drug

Veroshpiron represents a group of diuretic potassium-sparing drugs. This drug is considered an aldosterone antagonist and has a long-lasting effect.

Spironolactone does not retain water and sodium in the body, which inhibits the potassium-removing ability of aldesterone. Increasing the excretion of sodium and water is the main task of Veroshpiron. Also, this main active component reduces the process of potassium excretion. In addition, this action helps reduce the acidity of urine. The maximum peak of diuresis due to the diuretic properties of the drug can be achieved on days 2-5 of treatment.

How is the drug absorbed and eliminated?

The effective effect of the drug occurs due to the rapid absorption of substances from the gastrointestinal tract. Spironolactone is 98% capable of binding to blood proteins. The maximum peak concentration occurs after 2-4 hours. Spironolactone metabolites are able to cross the placental barrier and enter breast milk.

Half of the drug is excreted by the kidneys as metabolites. 10% remains unchanged, but is also excreted by the intestines.

Indications

The use of the diuretic Veroshpiron is appropriate for the following diseases:

• Hypertension (essential);
• CHF with severe edematous syndrome;
• Cirrhosis of the liver with swelling;
• Nephrotic syndrome;
• Hyperaldosteronism;
• Hypomagnesemia;
• Hypokalemia;
• Conn's syndrome.

The diuretic effect of the drug is used by cardiologists both as a basic treatment and as a prevention of heart disease. The diuretic effect helps reduce swelling, which is especially important for people with diseased kidneys or liver. Veroshpiron is often taken by women with polycystic ovary syndrome, when taking contraceptive medications is unacceptable.

Who should not take it?

Domestic Veroshpiron, like its foreign analogues, may be prohibited for patients who have:

1. Hyponatremia;
2. Hyperkalemia;
3. Addison's disease;
4. Severe renal failure;
5. Anuria;
6. Impaired absorption of glucose and galactose;
7. Individual high sensitivity to the composition.

An absolute contraindication to taking the drug is pregnancy and breastfeeding. Also, Veroshpiron should not be included in the treatment of children whose age has not yet reached 3 years.

The manufacturer warns that the drug should be taken with extreme caution for people who are sick with:

• Hypercalcemia;
• Diabetes;
• Diabetic nephropathy;
• Liver failure;

Contraindicated for use in patients who will undergo local or general anesthesia. For women with hormonal imbalances or irregular periods, it is better to postpone taking Veroshpiron. Elderly people should take it with caution.

How to drink Veroshpiron?

The dosage and duration of taking the drug should be prescribed only by the attending physician. The indicated dosage cannot be increased or decreased, as this may reduce the effectiveness of treatment. The drug Veroshpiron is used to treat various diseases, therefore the permissible dose for each patient is different.

If the patient has essential hypertension, then a single dose should be no more than 50-100 milligrams after meals. It is permissible to increase the dosage to 200 mg, but such an increase is appropriate to carry out in stages - once every 2 weeks. To obtain the expected therapeutic effect, you need to drink the drug for at least 2 weeks.

Idiopathic hyperaldosteronism is treated at a dosage of 100-400 mg/day. If the patient has hypokalemia or hyperaldosteronism, then it is permissible to take 300 mg of the drug per day. This amount should be divided into 3-4 doses.

If, during treatment with diuretic drugs, the patient develops hypokalemia or hypomagnesemia, then taking Veroshmiron is permissible in doses of 25 to 100 mg per day.

Nephrotic syndrome can cause swelling, so to reduce it, Veroshpiron is used in an amount of 100-200 mg per day.

Important! Veroshpiron does not treat the cause of nephrotic syndrome, so this diuretic is appropriate to use only if other drugs do not help.

CHF can also cause swelling, so to reduce it, it is permissible to take 100-200 mg of Veroshpiron for 5 days, 2-3 times a day. It is also permissible to combine this drug with other thiazide drugs. If the effect after such complex treatment is noticeable, then the dosage should be reduced to 25 mg per day. The maximum allowable amount of the drug for this diagnosis is 200 mg.

Swelling caused by cirrhosis of the liver can also be reduced by Veroshpiron. The standard daily dosage is 100 mg of the drug. During treatment, the patient must have his urine analyzed to determine the ratio of potassium and sodium ions. If the ratio is less than one, then the dose can be from 200 to 400 mg.

If edema is detected in children, then 3.3 mg of spironolactone should be used per 1 kg of the child’s weight. The reception should be divided into 1-4 times. To adjust the dose, you must complete at least 5 days of treatment from the day you started treatment with the initial dose.

Side effects

The high effectiveness of the drug does not give the patient the right to independently increase the dose prescribed by the doctor. It is also important to pay attention to the expiration date of the drug and its dosage. Manufacturers, under the guise of generic Veroshpiron, can sell more active drugs. If you do not take into account the dosage, then such negligence can lead to side effects, deterioration of well-being, etc. The body may react to such a drug with the following changes:

• Gastrointestinal tract. Quite often it can occur: nausea, diarrhea, vomiting. People may experience worsening stomach ulcers, gastritis, or intestinal colic.
• CNS. Side effects may include headaches, lethargy, dizziness, and ataxia.
• Circulatory system. The hematopoietic organs may experience agranulocytosis, megaloblastosis or thrombocytopenia.
• Endocrine sphere. Long-term use with the wrong dosage can cause a deepening of the voice. Males may develop gynecomastia (enlarged mammary glands). After stopping the drug, the size of the glands should decrease. In women, in terms of gynecology, hormonal levels may be disrupted, chest pain, dysmenorrhea, amenorrhea, and hirsutism may appear.

As an allergic reaction, patients may experience a small red rash, fever, or itchy skin. The development of hypertrichosis and alopecia is acceptable.

Overdose

Veroshpiron should be taken only as prescribed by a doctor. If you self-medicate, the result can be disastrous.

Overdose can cause:

• Reduced pressure;
• Vomiting;
• Dizziness;
• Convulsions;
• Dry mouth;
• Drowsiness;
• Arrhythmia;
• Weakness.

To help a patient in such a situation, you need to:

1. Gastric lavage is the best way if the patient has recently taken the drug;
2. Normalize water metabolism using potassium-removing diuretics - administer a solution of dextrose with insulin (0.25-0.5 units per 1 g of dextrose);
3. Carry out hemodialysis.

You definitely need to call an ambulance. If necessary, the victim must be hospitalized in a hospital. The necessary vector of further treatment is determined by the doctor. It is important to provide first aid in a timely manner.

What is chronic circulatory failure?

Chronic circulatory failure (CCF) is a serious disease characterized by the inability of the heart and blood vessels to deliver the required volume of blood to cells and tissues for their normal functioning at rest and under stress. Pathology, unlike acute failure, develops gradually and is much more common. Symptoms increase slowly. The degree of heart damage in this condition is much deeper. Timely diagnosis and effective medical care will help ensure proper functioning of the cardiovascular system and prevent life-threatening complications.

General characteristics of circulatory failure

There are two forms of CNC:

1. Heart failure is accompanied by myocardial damage.
2. Vascular insufficiency is characterized by circulatory disorders due to weak vascular tone and narrowing of their lumen.

The stages of chronic heart failure (CHF) are designated 1, 2A, 2B, 3. Depending on which ventricle is affected, the following types of CHF are distinguished:

• left ventricular;
• left atrial;
• right ventricular

Causes of heart failure:

• • atherosclerosis of the coronary arteries is the most common factor causing chronic circulatory disorders;
  • heart defects;
  • arterial hypertension;
  • inflammatory lesions of the heart muscle - myocarditis;
  • inflammation of the pericardium - pericarditis;
  • cardiomyopathy;
  • hyperthyroidism;
  • anemia;

• chronic pulmonary heart disease;

In medicine, chronic heart failure is often called congestive heart failure.

Reasons why vascular insufficiency develops:

• heart pathologies;
• chronic infections;
• damage to the nervous system;
• insufficiency of the adrenal glands, which produce important hormones that regulate the condition of blood vessels.

Symptoms of chronic heart and vascular failure

Congestive heart failure of any type is characterized by two general symptoms:

1. An increase in heart rate (heart rate) - tachycardia.
2. Rapid breathing - shortness of breath.

These symptoms appear first in the initial stages of CHF as compensatory mechanisms that support the pumping function of the myocardium. Stage 1 CHF is characterized by the development of such symptoms only during exercise. During the transition to stages 2 and 3, tachycardia and shortness of breath also appear at rest.

Symptoms of left ventricular and left atrial CHF:

• pulmonary edema - a serious condition, accompanied by fear of death, forced sitting position, discharge of pink sputum in the form of foam - hemoptysis;
• cardiac asthma, manifested by nocturnal shortness of breath, deterioration of pulmonary ventilation, decreased heart activity;
• inspiratory dyspnea - difficulty breathing;
• dry cough;
• cold sweat;
• severe weakness;
• cyanosis of the skin.

Symptoms of right ventricular heart failure, which often occurs as a result of left ventricular heart failure:

• • increase in liver size (stage 2A);
  • Plesh's symptom - when pressure is applied to the liver area, the veins in the neck swell;
  • enlarged spleen;
  • acute abdominal pain, bouts of vomiting, and lack of appetite are often considered early signs;
  • swelling in the legs (stage 2B);
  • hypertrophy of the right ventricle and atrium;
  • swelling of veins in the neck;

• night dry cough;
• swelling throughout the body - anasarca (stage 3);
• decrease in urine volume;
• blue skin on the ears, tip of the nose, lips, phalanges of the fingers;
• the appearance of protein and red blood cells in the urine;
• night diuresis - nocturia;
• the appearance of fluid in the abdominal cavity - ascites.

Vascular circulatory failure in chronic form develops rarely, symptomatically corresponding to congestive heart failure. More often, this disorder occurs in an acute form in the form of fainting, collapse, shock. If we are talking about chronic vascular insufficiency, then more often it occurs in the form of hypotension - low blood pressure. With hypotension, the systolic pressure in the vessels drops below 75 mmHg. Art. At the same time, the decrease in the indicator occurs gradually.

Symptoms of the disease help to establish the type of heart failure and its stage, in order to subsequently prescribe adequate treatment.

Diagnosis and complications of the disease

Methods for diagnosing CHF:

1. Questioning and inspection.
2. Laboratory methods.
3. Instrumental methods.

Using laboratory methods, the following is determined:

• blood protein composition;
• plasma content of electrolytes and colloidal complexes;
• volume of circulating blood and plasma;
• amount of Na, K, Ca and Mg;
• average red blood cell volume;
• plasma osmolarity;
• hemoglobin level, red blood cell count;
• urine analysis for protein and red blood cell content.

Instrumental research methods:

1. Electrocardiogram.
2. ECHO - ultrasound examination of the heart. Allows you to identify hypertrophied sections, decreased contractility, etc.
3. ECHO with Dopplerography makes it possible to establish a violation of blood flow, myocardial stroke volume, and an increase in blood volume.
4. X-ray studies can establish the presence of myocardial hypertrophy and blood stagnation.

Complications of circulatory failure are:

• • myocardial infarction;
  • hypoxia of the myocardium and brain;

• stroke;
• chronic hypotension and hypertension;
• death;
• suffocation;
• pulmonary edema;
• diseases of internal organs due to slowdown of blood flow in them.

Features of treatment and prognosis of the disease

Treatment of congestive circulatory failure is always complex, since it is necessary to simultaneously act on several symptoms and mechanisms of disorders. Timely treatment with maintenance doses of medications plays an important role in maintaining myocardial function and blood flow in the body at an optimal level.

Areas of treatment for CHF:

• stimulation of myocardial function. For this purpose, cardiac glycosides are widely used - Strophanthin, Digoxin, etc.;
• normalization (lowering) of blood pressure. The most effective groups of drugs are adrenergic blockers (Dopamine), calcium channel antagonists (Amlodipine) and ACE inhibitors, that is, angiotensin-converting enzymes (Captopril, Enalapril);
• potassium preparations to normalize metabolism in the heart;
• ATP (adenosine triphosphoric acid) is prescribed to improve energy processes in the heart muscle;
• B vitamins to normalize the conduction of nerve impulses in the myocardium;
• amino acids and multivitamin complexes;
• diuretics to reduce the volume of fluid in the body, which increases the load on the heart (Furosemide, Veroshpiron);
• vasodilators - Caffeine-sodium benzoate, Nitroglycerin, Apressin, Sodium nitroprusside, etc.;
• oxygen therapy to eliminate hypoxia;
• massage, physical therapy, baths to improve the tone of the heart and vascular walls.

Prognosis of CHF depends on the severity of the disease, timeliness of therapy, and the presence of concomitant pathologies that aggravate the course. Thus, stages 1 and 2A of CHF have a favorable course against the background of constant maintenance therapy, stage 2B is considered serious and is accompanied by a significant deterioration in the condition of the cardiovascular system; Stage 3 is characterized by an unfavorable course and may result in death.

Instructions for use:

Veroshpiron is a diuretic used against edema.

Pharmacological group: potassium-sparing diuretics.

The international name is consonant with the active substance: Spironolactone.

Composition and release form

Veroshpiron is available in the form of tablets of 0.025 g of active ingredient each. In 1 package there are 20 and 100 tablets.

Pharmacological properties

The instructions for Veroshpiron describe the drug as a potassium-sparing diuretic.

The main active ingredient competes with aldosterone (adrenal cortex hormone) and inhibits its action. Na+, Cl- and water are not absorbed back into the renal tubules, but K+ and urea, on the contrary, penetrate through the endothelium of the glomerulus into the blood. Increased urination causes a decrease in blood pressure and the disappearance of edema. The diuretic effect appears only 3-5 days after the first day of taking the drug.

Veroshpiron does not significantly affect the function of the renal tubules and does not lead to acid-base imbalance in the body.

Indications for use of Veroshpiron

Indications for Veroshpiron:

• for edema associated with heart disease (chronic heart failure), endocrine system (Conn's disease, polycystic ovary syndrome, hirsutism);
• with arterial hypertension;
• with ascites associated with liver cirrhosis;
• with cerebral edema and other diseases that are accompanied by edema;
• for severe burns;
• with paroxysmal paralysis associated with calcium deficiency;
• for myasthenia gravis (as an adjuvant treatment).

Instructions for use of Veroshpiron and dosage

For liver cirrhosis, the daily dose of the drug is 100 mg, 200 mg or 400 mg per day (the dose depends on the complexity of the disease).

For nephrotic syndrome, the daily dose is from 100 to 200 mg.

For edematous syndrome, take from 100 mg/day. up to 200 mg/day. three times a day.

Veroshpiron is prescribed daily for 5 days, then the daily dose is gradually reduced and increased to 25 mg or increased to 400 mg in 4 doses.

For high blood pressure, Veroshpiron is prescribed 50-100 mg of the drug per day, once or in 4 doses, for 2 weeks. The drug can be combined with antihypertensive drugs.

For hypokalemia, take 25-100 mg at a time or up to 400 mg in several doses.

For primary hyperaldosteronism, Veroshpiron is prescribed 100, 200 or 400 mg per day in 4 divided doses before surgery and 25-50 mg for long-term treatment.

For polycystic ovarian syndrome and hirsutism, the use of Veroshpiron is reduced to 100 mg of the drug twice a day.

Children are prescribed 1-3.3 mg/kg (30-90 mg/kg per day), taken once or in 4 doses. On the 5th day, the dose can be adjusted and, if necessary, increased by 3 times.

Once the effect is achieved, the dose of Veroshpiron is reduced to 0.025 g per day, and then 1 tablet is taken. 4 times a day every 3 days.

Side effects

According to reviews of Veroshpiron, the drug can cause drowsiness, dizziness, digestive disorders, dermatoses, menstrual cycle and sexual function disorders, lethargy, staggering when walking, muscle spasms, changes in the blood picture (megaloblastosis, thrombocytopenia, agranulocytosis).

Overdose

According to reviews of patients about Veroshpiron, an overdose of the drug occurs extremely rarely.

If it occurs, all side effects of the drug are aggravated. It is urgent to rinse the stomach, drink plenty of fluids and caffeine to increase blood pressure.

For hyperkalemia, the doctor prescribes dextrose and insulin.

Contraindications to the use of Veroshpiron

The drug should not be taken in case of impaired renal function, diabetes mellitus with complications, hypersensitivity to any of the components of the drug, Addison's disease, increased levels of potassium and calcium in the blood, liver failure, pregnancy, gynecological diseases.

Veroshpiron is taken with caution during conduction blockades in the heart muscle, during surgical interventions, taking hormonal medications, anesthetics, and in old age.

special instructions

While taking Veroshpiron, you need to limit the intake of potassium into the body and monitor kidney function and blood condition.

Interaction

The instructions for Veroshpiron warn that the drug weakens the effect of anticoagulants and enhances the effect of adrenaline, cardiac glycosides and lithium. Corticosteroids and diuretics enhance the effect of Veroshpiron, and non-steroidal anti-inflammatory drugs weaken its effect.

Storage conditions

Veroshpiron should be stored in a cool place for up to 5 years.

The article describes the medical drug Veroshpiron, instructions for its use, release forms, pharmacological properties of the drug, indications for use, composition, possible side effects on the human body and other aspects of this drug.

Composition of the drug and release form

Veroshpiron is a drug that belongs to the potassium-sparing diuretics, which has a pronounced and long-lasting diuretic effect.

The active substance is spironolactone, which is one of the hormones in the adrenal cortex. Spironolactone prevents water and sodium from accumulating in the kidney canals and maintains potassium concentration in the body. The diuretic effect of the drug helps normalize blood pressure levels.

The effect of the medication begins within 2-5 days from the moment you start taking the medication and ends within 3 days after you stop taking it. Veroshpiron is excreted from the body in urine and partly in feces.

Veroshpiron is produced in the form of tablets in dosages of 25 mg, 50 mg and 100 mg and capsules of 50 mg and 100 mg of the active substance. Additional substances that are included in the structure of the tablet:

• Magnesium salt of stearic acid – 2 mg.
• Silica – 1.2 mg.
• Steatite – 5.8 mg.
• Lactose monohydrate – 146 mg.
• Corn starch – 70 mg.

Additional substances included in the structure of 50 mg and 100 mg capsules:

• Magnesium salt of stearic acid – 2.5/5 mg.
• Sodium dodecyl sulfate - 2.5/5 mg.
• Lactose monohydrate – 127.5/255 mg.
• Corn starch – 42.5/85 mg.

The cardboard package contains 2 blisters of 20 tablets or 10 or 30 capsules of the appropriate dosage.

Pharmacological properties of the drug

The active substance is spironolactone, which blocks the endings of the tortuous channels of the kidney nephrons to aldosterone. This contributes to a better exit of excess water from the body, as well as the release of sodium and chlorine ions and maintaining potassium and hydrogen levels.

Spironolactone has the ability to be well absorbed into the intestinal lumen, is fully broken down by the liver and is excreted in the urine and partly in feces. It leaves the body completely within 24 hours. Diseases such as liver cirrhosis and heart failure increase the time it takes for the drug to leave the body.

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Indications for use

The drug Veroshpiron is prescribed in the following cases:

• Excessive accumulation of water in heart disease (used alone or together with other medications and diuretics).
• Hypertension of the first form.
• Prevention of increased potassium levels in the blood after taking other diuretics.
• Hypersecretion of aldosterone, leading to swelling and accumulation of water in the body.
• Cirrhosis of the liver.
• Reducing the amount of potassium in the body.

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Contraindications

The drug Veroshpiron is not prescribed:

• Children under 3 years old.
• During pregnancy and lactation.
• When there is no urine flow into the bladder.
• With excess potassium and lack of sodium.
• In cases of intolerance to individual components of the drug.
• Hypocorticism (disorders of the adrenal cortex).

Veroshpiron must be used with caution when the following conditions occur:

• For older people.
• If you have diabetes.
• Cirrhosis of the liver.
• Kidney failure.
• With excess calcium in the blood.
• Use of anesthesia (general or local).
• When the menstrual cycle is disrupted.
• With enlarged mammary glands.

To determine the concentration of potassium and sodium in the blood, you need to take a test. Be sure to check that there are no restrictions before starting therapy.

Directions for use and dosage

Veroshpiron should be taken orally in accordance with a certain dosage, washed down with water. It is recommended to drink the medicine in the morning and lunchtime at the time of meals for better absorption and absorption. If you miss a dose of medication when less than 4 hours have passed, you must immediately take a dose of the drug. When 4 hours or more have passed, the medicine should be taken in the appropriate portion at the time of the next meal.

Drinking alcoholic beverages is not compatible with taking Veroshpiron. Therefore, it is recommended to abstain from drinking alcohol during treatment.

During the appointment, you should refrain from driving vehicles and working with mechanisms that require fixation of attention.

It should be remembered that only a doctor can determine and prescribe the required dosage of Veroshpiron.

As stated above, the drug Veroshpiron in the form of capsules or tablets is taken orally with large fluid intake.

1. For heart failure, swelling Veroshpiron is prescribed to drink 100-200 mg per day for 5 days, i.e. 2-3 doses of the drug. It must be combined with a thiazide diuretic (medium strength diuretics). The maximum dose per day reaches 200 mg.
2. In cases of nephrotic syndrome The daily dose is 100-200 mg. Studies have not revealed the effect of the functional substance of Veroshpiron - spironolactone - on defective functioning in the body, therefore Veroshpiron is prescribed only in cases where other therapies have not proven their effectiveness.
3. In cases of primary hypertension Veroshpiron is taken in an amount of 50-100 mg at a time, in the future it is possible to gradually increase the dosage to 200 mg. The dosage used should be increased every two weeks. To determine the effectiveness of therapy, it is recommended to use the drug for at least 2 weeks.
4. With a lack of potassium in the blood, the drug is prescribed at a dosage of 25-100 mg 2-3 times, depending on the concentration of potassium in the patient’s body.
5. In cases of diagnostics, which determines the level of activity of the kidneys and the production of the hormone aldesterone, the drug Veroshpiron is taken once in a dosage of 100-200 mg.
6. In case of swelling due to the disease cirrhosis of the liver, the drug is prescribed in a dose of 100-400 mg, depending on the concentration of potassium and sodium ions. Further therapy is prescribed individually.
7. Preparation for surgery and rehabilitation period for hyperaldosteronism, 100-400 mg per day is prescribed.
8. In cases of edema in children the drug is prescribed at the rate of 1-3 mg of active substance per 1 kg of weight of a child over 3 years old.

Use of Veroshpiron in pediatrics

As a diuretic drug, it is used in pediatrics to treat various diseases. The dosage of the medicine and the duration of therapy can be determined solely by the attending physician, adjusted for the child’s medical history and his current state of health.

The age limit for taking Veroshpiron is above 3 years. In practice, the medicine is prescribed to infants exclusively under the supervision of doctors.

Veroshpiron is prescribed in the following doses:

1. Daily dose – from 1 to 3 mg per 1 kg of body weight, divided into 1-4 doses.
2. After 5 days, the dosage is changed. You can increase the prescribed dose by a maximum of 3 times.

The drug is taken twice a day with an interval of 10-12 hours.

Children under 6 years of age are advised to take this drug as a last resort. For greater convenience for the child, if necessary, grind the tablet into a powder mixture and add to milk or water.

Infants experience bouts of vomiting after taking Veroshpiron. If vomiting occurs within half an hour after taking it, then you need to take the medicine again. If the gag reflex worked after half an hour or was absent altogether, repeated use is not required.

Overdose of the drug in children has special complications, because Many side effects of Veroshpiron appear at once: increased drowsiness, lethargy, convulsions are possible, heart rhythm is disturbed. Accompanied by dehydration (dry skin, vomiting, diarrhea). If side effects are detected, you should immediately stop taking the drug and urgently call an ambulance.

Use of Veroshpiron during pregnancy and lactation

The use of the medicine during pregnancy and breastfeeding is strictly contraindicated. The active substance spironolactone tends to pass into breast milk. When treatment with this drug is unavoidable, breastfeeding should be stopped during drug therapy for the safety of the baby.

Overdose

In case of an overdose of Veroshpiron, the following symptoms may be observed:

When the prescribed dose has been exceeded, the stomach must be rinsed, causing an attack of vomiting and immediately consult a doctor.

Side effect

The use of Veroshpiron can have many adverse reactions, if you notice them, you must immediately stop treatment. These include:

• Digestive system– nausea, vomiting, ulcers, erosions and bleeding, diarrhea, inflammation of various types, constipation, pain in the abdomen, liver dysfunction.
• Nervous system– headaches, dizziness, lethargy, drowsiness, disorders of the motor system.
• Circulatory system– a decrease in the number of platelets in the blood, a sharp decrease in the number of leukocytes, megaloblastosis.
• Hormonal system– enlargement of the mammary glands and pain in them, impaired potency in men, disturbance or absence of the menstrual cycle, increased hair growth.
• Urinary system– acute kidney dysfunction.
• The immune system– various rashes on the skin, urticaria, swelling of the skin and subcutaneous fat on the face, anaphylactic shock.
• Musculature– spasms, convulsions.

After discontinuation of the drug Veroshpiron, most adverse reactions disappear gradually.

Interaction with other drugs

Before starting therapy with Veroshpiron, you must notify your doctor about taking other medications to avoid complications of treatment. Veroshpiron has the following interactions with drugs:

• Anticoagulants– reduces their effectiveness.
• Cardiac glycosides– reduces toxicity.
• Norepinephrine– reduces the sensitivity of blood vessels to it.
• Mitotane– reduces its effectiveness.
• Diuretics and– increases their efficiency.
• Phenazol– enhances its absorption by the body.
• Preparations containing lithium– increases their toxicity.
• Carbenoxolone– accelerates its exit from the body; simultaneous use leads to sodium retention in the blood.
• Buserelin, Gonadorelin– increases efficiency.
• Salicylates– joint use reduces the diuretic effect.
• Potassium-sparing and potassium-containing drugs, aldosterone receptor antagonists, angiotensin II receptor blockers - combined use contributes to the development of hyperkalemia.
• Cholestyramine, ammonia– simultaneous use increases the risk of increasing the acid balance of the body.
• Antipyretics - simultaneous use may develop hyperkalemia.

special instructions

Only the doctor determines the dosage of Veroshpiron. Before starting treatment, It is necessary to pay attention to a number of features:

• When starting to use the drug, the concentration of nitrogen residue in the blood may temporarily increase. Soon this figure will return to normal.
• If you have diabetes, you should take the medicine carefully, despite the fact that Veroshpiron does not affect the concentration of glucose in the blood.
• You need to reduce your intake of potassium-containing foods.
• In combination with antipyretics, it is necessary to monitor blood counts through tests.

Conditions of release and storage

The drug is available with a doctor's prescription.

Shelf life – 5 years.

Store the drug in a dry place, away from sunlight, out of reach of children. Storage temperature should not exceed +30° C.

Analogues

According to the active element - spironolactone, Veroshpiron has analogues:

• Aldactone.
• Vero-Spironolactone.
• Spironol.
• Spirix.
• Unilan.
• Urakton.
• Renial.
• Epletor.

Aldactone

Epletor

Price

The price of the drug varies depending on the country of origin, as well as on the form of release and dosage.

Veroshpiron is a drug that, according to the manufacturer’s instructions, is not officially approved for use in children under three years of age. But in some cases, pediatric neurologists prescribe it to children under one year of age, more often this happens in a hospital setting.

Why does a baby need veroshpiron?

There is a period of a child’s life that is especially dangerous in relation to various effects on the central nervous system. It begins from the twenty-eighth week of pregnancy, ends a week after the birth of the child and is called the perinatal period. Brain lesions that arose during this period are called perinatal: perinatal lesions of the nervous system (PPNS) or perinatal encephalopathy.

Very often, perinatal lesions of the nervous system are accompanied by high intracranial pressure, when a lot of fluid collects inside the brain. This usually occurs due to changes in the vessels of the brain, stagnation of blood in them and sweating of the liquid part of the blood out. At the same time, the child becomes very restless, screams, and has trouble latching on to the breast. In order to reduce intracranial pressure, diuretics are prescribed, including veroshpiron.

How does veroshpiron act on infants - is it really necessary to take it?

Veroshpiron is a diuretic (diuretic) that suppresses the action of the adrenal hormone aldosterone. Aldosterone retains water and sodium in the body and removes potassium, which is vital for muscle function, especially the heart muscle. Under the influence of veroshpiron, water and sodium are removed from the body, and potassium remains in the body, therefore veroshpiron is called a potassium-sparing diuretic.

But too much potassium is just as harmful to the body as too little potassium. Therefore, veroshpiron, which has a mild diuretic effect, is prescribed only when there is a lack of potassium in the body. In infants, it can be prescribed, for example, in cases where potassium deficiency has developed after taking conventional diuretics, for example, after Diacarb.

Veroshpiron should under no circumstances be taken uncontrolled, so it is more often prescribed to infants in a hospital setting.

Side effects of veroshpiron - how dangerous is it for babies?

Veroshpiron has many side effects:

While taking veroshpiron, the infant should not be given medications that contain potassium (panangin, asparkam), as well as other potassium-sparing diuretics. In addition, laboratory monitoring of potassium levels in the blood, kidney and liver function is necessary.

Veroshpiron overdose

An overdose of veroshpiron for a baby is very dangerous. It is expressed in an increase in all side effects. In an infant lethargy, weakness, drowsiness increase, convulsive muscle twitching may appear, and the heart rhythm is disturbed. Dehydration causes the skin to become dry, there is no saliva in the mouth, and there may be vomiting and diarrhea.

Treatment consists of immediately stopping the administration of veroshpiron and gastric lavage. To restore water and electrolyte metabolism, the child is given saline solutions with sodium, glucose and insulin.

In what cases is veroshpiron not prescribed to infants?

Veroshpiron should not be prescribed for kidney and liver diseases that are accompanied by impaired function. It cannot be prescribed if, for some reason, the child already has a water-salt imbalance - a decrease in the amount of sodium in the blood and an increase in potassium and calcium. In addition, veroshpiron should not be prescribed for metabolic disorders that are accompanied by an increase in the overall acidity of the body (acidosis).

Veroshpiron is a drug that can only be prescribed to an infant by a doctor and preferably in a hospital setting under laboratory control.

How to give veroshpiron to infants?

Veroshpiron is prescribed to infants who have heart failure. It helps remove fluid from the body, thereby reducing the load on the baby’s heart. Veroshpiron is a type of diuretic that belongs to potassium-sparing drugs - unlike many diuretics, they do not lower the level of potassium in the blood.

How to give veroshpiron to a child?

It is usually recommended to give veroshpiron twice a day, morning and evening. Ideally, 10-12 hours should pass between doses. Try to give veroshpiron at the same time, then it will become a habit and the likelihood that you will forget to give your baby the medicine will decrease.

The information sheet contains information about dosage, but the doctor must tell you how much veroshpiron your child needs to take. It is extremely important to follow the instructions you receive from your doctor exactly.

If the doctor has prescribed veroshpiron in tablet form, they should be ground into powder and given to the child along with milk or baby food. Liquid veroshpiron should be given to the child using a special measuring spoon.