Vilprafen solutab indications. The drug 'Vilprafen Solutab' - instructions for use, description and reviews. Cross-drug interactions

Excipients: microcrystalline cellulose - 101 mg, polysorbate 80 - 5 mg, colloidal silicon dioxide - 14 mg, carmellose sodium - 10 mg, magnesium stearate - 5 mg, methylcellulose - 0.12825 mg, polyethylene glycol 6000 - 0.3846 mg, talc - 2.0513 mg, titanium dioxide - 0.641 mg, aluminum hydroxide - 0.641 mg, copolymer of methacrylic acid and its esters - 1.15385 mg.

10 pieces. - aluminum/PVC blisters (1) - cardboard packs.

pharmachologic effect

Macrolide antibiotic. It has a bacteriostatic effect due to the inhibition of protein synthesis by bacteria. When creating high concentrations in the focus of inflammation, it has a bactericidal effect.

Highly active against intracellular microorganisms: Chlamydia trachomatis and Chlamydia pneumonuae, Mycoplasma pneumoniae, Mycoplasma hominis, Ureaplasma urealyticum, Legionella pneumophila; against gram-positive aerobic bacteria: Staphylococcus aureus, Streptococcus pyogenes and Streptococcus pneumoniae (pneumococcus), Corynebacterium diphtheriae; gram-negative aerobic bacteria: Neisseria meningitidis, Neisseria gonorrhoeae, Haemophilus influenzae, Bordetella pertussis; against some anaerobic bacteria: Peptococcus, Peptostreptococcus, Clostridium perfringens.

Josamycin is also active against Treponema pallidum.

Pharmacokinetics

After oral administration, josamycin is rapidly absorbed from the gastrointestinal tract. Cmax is achieved 1-2 hours after ingestion. 45 minutes after taking a dose of 1 g, the average concentration of josamycin in is 2.41 mg / l.

Plasma protein binding does not exceed 15%.

The equilibrium state is reached after 2-4 days of regular intake.

Josamycin is well distributed in the body and accumulates in various tissues: in the lung, lymphatic tissue of the palatine tonsils, organs of the urinary system, skin and soft tissues. Particularly high concentrations are found in the lungs, tonsils, saliva, sweat and lacrimal fluid. The concentration of josamycin in human polymorphonuclear leukocytes, monocytes and alveolar macrophages is approximately 20 times higher than in other cells of the body.

Josamycin is biotransformed in the liver to less active metabolites.

Excreted mainly in the bile, excretion in the urine is less than 20%.

Indications

Treatment of infectious and inflammatory diseases caused by microorganisms sensitive to josamycin: infections of the upper respiratory tract and upper respiratory tract (including tonsillitis, paratonsillitis, otitis media, sinusitis, laryngitis); diphtheria (in addition to treatment with diphtheria antitoxin); scarlet fever (with increased sensitivity to penicillin); infections of the lower respiratory tract (including acute bronchitis, bronchopneumonia, pneumonia, including atypical form, whooping cough, psittacosis); oral infections (including gingivitis and periodontal disease); infections of the skin and soft tissues (including pyoderma, boils, erysipelas / with increased sensitivity to penicillin /, acne, lymphangitis, lymphadenitis); infections of the urinary tract and genital organs (including urethritis, prostatitis, gonorrhea; with increased sensitivity to penicillin - syphilis, venereal lymphogranuloma); chlamydial, mycoplasmal (including ureaplasma) and mixed infections of the urinary tract and genital organs.

Contraindications

Severe liver dysfunction, hypersensitivity to and other antibiotics of the macrolide group.

Dosage

When taken orally, adults and children over 14 years of age - 1-2 g / day in 2-3 doses. Children under the age of 14 - 30-50 mg / kg / day in 3 divided doses. The duration of treatment depends on the indications for use.

Side effects

From the digestive system: rarely - lack of appetite, nausea, heartburn, vomiting, diarrhea, pseudomembranous colitis; in some cases - an increase in the activity of hepatic transaminases, a violation of the outflow of bile and jaundice.

Allergic reactions: rarely - urticaria.

Others: in some cases - dose-dependent transient hearing loss.

drug interaction

Bacteriostatic antibiotics may reduce the bactericidal effect of other antibiotics such as penicillins and cephalosporins (concomitant use of josamycin with penicillins and cephalosporins should be avoided).

With the simultaneous use of josamycin with may reduce the effectiveness of both drugs.

Josamycin slows down the elimination of theophylline to a lesser extent than other antibiotics of the macrolide group.

Josamycin slows down the excretion of terfenadine or astemizole, which increases the risk of life-threatening arrhythmias.

There are separate reports of an increase in vasoconstrictor action with the simultaneous use of macrolide antibiotics and ergot alkaloids. There was 1 case of intolerance to ergotamine while taking josamycin.

With the simultaneous use of josamycin and it is possible to increase the concentration of cyclosporine in the blood plasma up to nephrotoxic.

With the simultaneous use of josamycin and digoxin, an increase in the level of the latter in the blood plasma is possible.

In rare cases, during treatment with macrolides, the contraceptive effect of hormonal contraceptives may be insufficient.

special instructions

In the event of pseudomembranous colitis, josamycin should be discontinued and appropriate therapy instituted. Drugs that reduce intestinal motility are contraindicated.

In patients with, correction of the dosing regimen is required in accordance with the values ​​​​of QC.

Josamycin is not prescribed to premature babies. When used in newborns, it is necessary to monitor liver function.

Consideration should be given to the possibility of cross-resistance to various antibiotics of the macrolide group (for example, microorganisms resistant to treatment with antibiotics related in chemical structure may also be resistant to josamycin).

Pregnancy and lactation

Use during pregnancy and lactation is possible only in cases where the intended benefit to the mother outweighs the potential risk to the fetus or child.

Vilprafen is widely used to treat bacterial and fungal diseases.

The drug belongs to the group of macrolides - antibiotics, similar in action to penicillins. It has a bacteriostatic, and in large doses, a bactericidal effect. It is almost completely metabolized in the body, and its residues and metabolites are excreted in the urine.

On this page you will find all the information about Vilprafen: full instructions for use for this drug, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Vilprafen. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Macrolide antibiotic.

Terms of dispensing from pharmacies

Released by prescription.

Prices

How much does Wilprafen cost? The average price in pharmacies is at the level of 600 rubles.

Release form and composition

The drug Vilprafen is available in the form of tablets for oral administration in a carton box in blisters of 10 pieces. Each tablet is film-coated in white color and has a horizontal notch on one side.

• active substance: josamycin - 500 mg,
• excipients: microcrystalline cellulose, polysorbate 80, colloidal silicon oxide, sodium carboxymethylcellulose, magnesium stearate, hydroxypropyl methylcellulose, Macrogol 6000, talc, titanium dioxide, aluminum hydroxide, copolymer of methacrylic acid and its esters.

Pharmacological effect

The bactericidal effect of the active substance of the drug is due to the fact that josamycin is able to bind to the large subunit of the ribosomal membrane (50S), does not allow the transfer RNA to be fixed, and also blocks the translocation of the A-center peptides (a type of mutation that is accompanied by a chromosomal rearrangement that affects the properties of the cell) and inhibits intracellular production of proteins from amino acids.

The spectrum of action of josamycin, which is part of Vilprafen, is quite wide.

The substance has activity against gram-positive aerobic microorganisms, including:

1. Released by the body during inflammatory processes of peptococci;
2. Peptostreptococci, which provoke the development of mixed infections;
3. Staphylococcus;
4. The causative agent of anthrax is bacillus anthrax;
5. Bacteria of the genus Corynebacterium, which are the causative agents of diphtheria;
6. Clostridium perfringens - causative agents of gas gangrene and human toxicoinfections;
7. Streptococcus.

Vilprafen is also active against gram-negative microorganisms, including:

1. Hemophilus, which is the cause of hemophilic infections, including purulent meningitis, acute pneumonia, pericarditis, septicemia, etc.;
2. Neisseria, which are the causative agents of diseases such as gonorrhea and meningitis;
3. Some varieties of shigella, which provokes the development of dysentery;
4. Bacteroides fragilis, which are the causative agents of purulent infectious diseases that develop after trauma, surgery, immunodeficiency, etc.;

Indications for use

According to the instructions, Vilprafen is prescribed for the treatment of the following infectious and inflammatory diseases caused by microorganisms sensitive to josamycin:

1. Psittacosis;
2. Infections in ophthalmology (dacryocystitis, blepharitis);
3. Infections in dentistry (pericoronitis, periodontitis and alveolar abscess);
4. Burn and wound (including postoperative) infections;
5. , venereal lymphogranuloma, (with increased sensitivity to penicillin);
6. Infections of the ENT organs and upper respiratory tract, including paratonsillitis and;
7. Infections of the lower respiratory tract, including community-acquired, acute and (exacerbations);
8. (Vilprafen is prescribed in case of hypersensitivity to penicillin antibiotics);
9. (in complex therapy together with diphtheria antitoxin);
10. Infections of the genital organs and urinary tract (, and epididymitis caused by mycoplasmas and / or chlamydia);
11. Infections of soft tissues and skin (furunculosis, furuncle, anthrax, acne, abscess, folliculitis, lymphadenitis, panaritium, lymphangitis and phlegmon);
12. Diseases of the gastrointestinal tract caused by, including and and.

Contraindications

The drug is contraindicated in severe violations of the liver or in the presence of hypersensitivity to the components of the drug.

Use during pregnancy and lactation

The drug is not prescribed for pregnant women if there are severe disorders in the liver, sensitivity to the constituent components.

Instructions for use

1. For the treatment of rosacea - 500 mg 2 times / day for 10-15 days.
2. For the treatment of pyoderma - 500 mg 2 times / day for 10 days.
3. For the treatment of urogenital chlamydia - 500 mg 2 times / day for 12-14 days.
4. For the treatment of chronic periodontitis, with abscessing of the periodontal bone - 500 mg 2 times / day for 12-14 days.
5. With ordinary and spherical (conglobat) acne, 500 mg 2 times / day are prescribed for the first 2-4 weeks, then 500 mg 1 time / day as maintenance therapy for 8 weeks.

Tablets should be swallowed without chewing, with a small amount of liquid, between meals. Usually the duration of treatment is determined by the doctor. In accordance with WHO recommendations on the use of antibiotics, the duration of treatment for streptococcal infections should be at least 10 days.

For infants and children under the age of 14, it is preferable to prescribe the drug in the form of a suspension. The daily dose is 30-50 mg / kg of body weight, divided into 3 doses. In newborns and children under the age of 3 months, the dose should be adjusted according to the exact body weight of the child.

Shake the vial with the suspension before use.

Side effects

With proper use of the drug and strict adherence to the dose indicated in the instructions, Vilprafen is well tolerated by patients, however, in some cases, the following side effects may develop:

1. Allergic skin reactions: , rash, in very rare cases, anaphylactic shock.
2. Gastrointestinal tract: nausea, abdominal pain, profuse salivation, heartburn, vomiting, intractable diarrhea, the development of an inflammatory process in the intestine in rare cases.
3. From the side of the liver and biliary tract: an increase in the activity of hepatic transaminases, rarely a violation of the outflow of bile and the functioning of the gallbladder, due to which jaundice developed in patients.

Overdose

So far, no cases of overdose have been reported with respect to the drug. In case of an overdose after taking the drug, it is necessary to assume an increase in side effects, to carry out symptomatic therapy.

special instructions

1. In patients with renal insufficiency, a correction of the dosing regimen is required in accordance with the CC values.
2. Josamycin is not prescribed to premature babies. When used in newborns, it is necessary to monitor liver function.
3. In the event of pseudomembranous colitis, josamycin should be discontinued and appropriate therapy instituted. Drugs that reduce intestinal motility are contraindicated.

Consideration should be given to the possibility of cross-resistance to various antibiotics of the macrolide group (for example, microorganisms resistant to treatment with antibiotics related in chemical structure may also be resistant to josamycin).

drug interaction

1. Vilprafen inhibits the elimination of xanthines, which can provoke the development of intoxication.
2. It is recommended to avoid the simultaneous use of Vilprafen with other antibiotics. This can lead to a decrease in their effectiveness.
3. The simultaneous use of an antibiotic with cyclosporine can lead to an increase in the concentration of the latter, so its level should be monitored throughout the treatment.
4. Taking Vilprafen may reduce the effectiveness of hormonal contraceptives, therefore, in order to avoid unwanted pregnancy, it is recommended to additionally use non-hormonal contraceptives.
5. The complex use of Vilprafen with antihistamines, including astemizole and terfenadine, increases the concentration of the latter, which can lead to the development of serious life-threatening cardiac arrhythmias.

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Vilprafen Solutab is a dispersible tablet that belongs to the macrolide class of antibacterial agents. This original drug is produced by the Italian company Montefarmaco S, but the applicant for registration is the Dutch pharmaceutical concern Astellas Pharm Europe.

Vilprafen Solutab is available in the form of a solid dosage form - soluble tablets of white or yellowish color. They have an oblong oval shape, in the middle of the tablet there is a risk for dividing the drug into equal parts. On one side of the surface of the tablet there is the inscription "IOSA", and on the other - 1000, which corresponds to the amount of the active substance josamycin.

The drug is packed in blisters for 5 cells and sold in a cardboard box of 5 or 10 tablets. The active ingredient is part of Vilprofen Solutab 1000 mg in the form of a salt - josamycin propionate. Auxiliary agents in the tablet are microcrystalline cellulose, weakly substituted hydroxypropyl cellulose, docusate sodium, aerosil, aspartame (E951), magnesium stearate, strawberry flavor.

Josamycin belongs to the macrolide class of antibiotics, which has a wide spectrum of action and has a bacteriostatic effect. The bactericidal effect is on microorganisms that are highly sensitive to the active substance.

Wilprafen Solutab 1000 photo

The mechanism of action of the drug is due to reversible binding to the 50S ribosome of the microorganism, which inhibits the synthesis of proteins in the bacterial cell and causes inhibition of its growth.

An important feature of the medicinal substance is its ability to act on the intracellular forms of microorganisms.

What helps Vilprafen Solutab?

Various types of staphylococci (including those producing beta-lactamase), streptococci of various types, anthrax bacilli, diphtheria corynebacteria, gonococci, meningococci, shigella, Haemophilus influenzae, pertussis, legionella, mycoplasmas, chlamydia, treponema (causative agents syphilis), rickettsia, some anaerobic bacteria and fungi (Peptococcus spp, Bacteroides spp, Peptostreptococcus spp.).

Based on such a great therapeutic activity, it is possible to answer the question of what Vilprafen Solutab helps from:

• Infectious diseases of the respiratory system and ENT organs (gingivitis, sinusitis, otitis media, laryngitis, pharyngitis, bronchitis, pneumonia, whooping cough, psittacosis);
• Diseases of the urinary and genital infectious genesis: prostatitis, gonorrhea, urethritis, chlamydia, syphilis, mycoplasmosis, ureaplasmosis;
• Bacterial skin lesions: pyoderma, acne, furunculosis, lymphadenitis, erysipelas, anthrax;
• Eye diseases (inflammation in the eyelids or nasolacrimal canal of infectious etiology);
• Other specific diseases: diphtheria, dysentery, scarlet fever, etc.

A special advantage of the drug is the possibility of its use in children in the treatment of bacterial infections of the respiratory tract, due to its pleasant taste and convenient dosage form. Vilprafen Solutab has proven itself well in the treatment of community-acquired pneumonia, especially in people with hypersensitivity to penicillins.

Vilprafen solutab is successfully used for the treatment of bacterial diseases of the reproductive system, which threaten the loss of reproductive function, miscarriage and intrauterine infection of the fetus. Josamycin has far fewer side effects than other antibiotics and is also less likely to cause resistant strains.

Instructions for use Vilprafen Solutab, dosage

According to the instructions for use of Vilprafen Solutab 500 \ 1000 - the maximum daily dose of the drug is 3 g, they are divided into 2-3 doses per day. Usually, therapy is carried out at the rate of 1.5-2 g of josamycin per day.

Tablets can be swallowed with plain water, without chewing, or dissolved in a small amount of liquid (at least 1 tablespoon of water). The drug is used before or after meals.

• The duration of the course is determined by the attending physician, depending on the pathogen and the patient's condition, it can last from five days to three weeks.

The instructions indicate that for children from 1 year old, Vilprafen Solutab is prescribed based on the weight of the child, while his body weight should not be less than 10 kg. For 1 kg of the child's body, 40-50 mg of the drug is prescribed per day and the resulting dosage is divided into 2-3 doses.

With a body weight of more than 40 kg, the drug is taken in an adult dosage.

special instructions

Taking Vilprafen Solutab may affect the effect of certain drugs:

• Taking this macrolide with some antiallergic drugs (terfenadine, astemizole) leads to life-threatening arrhythmias.
• Slowing down the excretion of xanthines while taking josamycin can lead to theophylline intoxication.
• With the combined use of Wilprafen with ergot alkaloids, severe vasoconstriction may occur.
• An increase in nephrotoxicity is caused by the combined use of josamycin and cyclosporine.
• Taking the drug with bactericidal agents inhibits the activity of the active substance.

The drug does not affect the ability to drive vehicles.

Side effects Wilprafen Solutab, contraindications

The most common side effects are abdominal pain, nausea and allergies (urticaria and other skin reactions). Much less common are constipation, diarrhea, problems with appetite, and vomiting. There is a possibility of developing pseudomembranous colitis. Manifestations of hepatic dysfunction and jaundice are possible. Taking high doses of the drug can lead to hearing loss.

Contraindications to the use of Vilprafen Solutab tablets are:

• age up to 1 year;
• weight less than 10 kg;
• the presence of liver failure;
• allergic reactions to the components of the drug;
• history of hypersensitivity to other macrolides.

During pregnancy and lactation, taking the drug is not contraindicated, but this requires clear indications and a balanced decision by the doctor. So far, nothing has been reported about cases of overdose of the drug, so there is no specific antidote and symptomatic treatment against the background of detoxification therapy is expected.

Vilprafen Solutab analogs, list of drugs

To date, among the analogues of Vilprafen Solutab there is only one drug - Vilprafen, it is produced by the same pharmaceutical company.

What is better Vilprafen or Vilprafen Solutab?

Vilprafen Solutab tablets differ from Vilprafen tablets in their solubility, which significantly affects the pharmacokinetics of the drug.

The use of Solutab technology provides better bioavailability of the active ingredient. It is achieved due to the uniform distribution of microparticles in the stomach and the controlled release of josamycin as water penetrates into the microparticles. Complete release occurs in the "window of reabsorption" - the duodenum.

Also, the difference between the two forms of the drug is the dosage - 1000 mg and 500 mg, respectively, so Vilprafen Solutab can be used less frequently, which significantly reduces the risk of side effects.

The dispersible tablet form has a pleasant taste and is easy to give to children from as early as 1 year of age. In addition, the cost of treatment with Vilprafen Solutab is approximately 30% cheaper than with Vilprafen alone. Thus, it is safe to say that the soluble form of tablets is much better and more convenient.

Vilprafen Solutab is a modern antibacterial agent with a wide spectrum of action, which can be used according to indications even for children and during pregnancy. The drug is easy to take, has few side effects and a low chance of developing resistant strains. The effectiveness of the drug is very high and clinically proven.

A medication called Vilprafen Solutab belongs to the group of antibiotics - macrolides. It is used to treat various infectious and inflammatory lesions that are caused by bacteria and microbes that are sensitive to the active substance that is part of the tablets. The main active ingredient in the pill is Josamycin in the amount of 1000 mg.

In this article, we will consider why doctors prescribe Vilprafen Solutab, including instructions for use, analogues and prices for this drug in pharmacies. Real REVIEWS of people who have already used Vilprafen Solutab can be read in the comments.

Composition and form of release

Tablets are white or almost white, oblong, sweet, with a strawberry smell. With the inscription "IOSA" and a risk on one side and the inscription "1000" on the other.

• active ingredient: josamycin (which is equivalent to josamycin propionate 1067.66 mg) - 1,000 mg.
• excipients: microcrystalline cellulose, hyprolose (L.M.), docusate sodium, aspartame, anhydrous silica, strawberry flavor, magnesium stearate.

Clinico-pharmacological group: macrolide antibiotic.

Indications for use

Given the activity of the active substance, Vilprafen Solutab is indicated for use in the following conditions:

1. Dental pathology.
2. Respiratory tract infections (bronchitis, pneumonia).
3. Purulent-inflammatory diseases of soft tissues.
4. Diseases of the genitourinary system in men (prostatitis, urethritis, epididymitis, pyelonephritis, gonorrhea, syphilis).
5. Infections of ENT organs (pharyngitis, otitis media, sinusitis, tonsillitis, including diphtheria etiology).

Mechanism of action

Josamycin is a macrolide antibiotic of natural origin. It is produced by soil bacteria called actinomycetes. The bactericidal effect of this antibiotic is manifested when a sufficient therapeutic dose of the active substance is reached in the focus of inflammation. Josamycin blocks the delivery of amino acids to bacterial cells, due to this, protein synthesis becomes impossible, which prevents the reproduction of microorganisms, since the division process stops in the nucleus.

Almost immediately after ingestion and the onset of action against bacteria, the drug begins to be excreted with sweat and tears. Only 20% of the substance is excreted in the urine, and most of it is excreted in the bile. The highest concentration of josamycin according to the results of studies was recorded in sputum, and not in the blood. The antibiotic is not able to penetrate into the bone marrow, but accumulates in the bone tissue.

Instructions for use

• In pediatrics, in children whose weight has reached 10 kilograms, Vilprafen Solutab is used at the rate of 40 to 50 mg per kilogram of body weight. This daily dose is divided into 2 or 3 doses.
• For a child weighing 10 to 20 kilograms, a dose of 250 to 500 mg twice in 24 hours is recommended. When taking a quarter or half of the tablet is pre-dissolved in water.
• With a body weight of 20 to 40 kilograms, the dose is from 500 to 1000 mg twice in 24 hours (half or a whole tablet is dissolved in water).
• In children whose weight exceeds 40 kilograms, Vilprafen Solutab is prescribed 1 tablet twice a day.

Usually the duration of treatment is determined by the doctor and ranges from 5 to 21 days, depending on the nature and severity of the infection. In accordance with WHO recommendations, the duration of treatment for streptococcal tonsillitis should be at least 10 days.

Contraindications

The appointment of the drug Vilprafen Solutab is contraindicated in the presence of such conditions and diseases:

• liver disease, which are severe;
• sensitivity to josamine or to any of the auxiliary elements;
• sensitivity reactions to the macrolide group of antibiotics;
• children weighing less than 10 kilograms.

Side effect

The drug has certain side effects:

• Hypersensitivity reactions: allergic skin reactions (eg, urticaria) are possible.
• On the part of the hearing aid - dose-dependent transient hearing impairment has been reported.
• On the part of the liver and biliary tract - a transient increase in the activity of liver enzymes in the blood plasma was observed, in rare cases accompanied by a violation of the outflow of bile and jaundice.
• From the gastrointestinal tract - loss of appetite, nausea, heartburn, vomiting, dysbacteriosis and diarrhea. In the case of persistent severe diarrhea, one should keep in mind the possibility of developing life-threatening pseudomembranous colitis against the background of antibiotics.
• Other: very rarely - candidiasis.

Analogues

Structural analogues for the active substance: Vilprafen.

Some facts about the product:

Instructions for use

Price in the online pharmacy site: from 708

Pharmacological properties

Vilprafen Solutab is an antibiotic agent belonging to the group of macrolides. The drug has a bacteriostatic quality, which is characterized by a slowdown in the synthesis of protein substances of bacterial forms. If a significant amount of the drug is introduced into the site of the inflammatory process, then a bactericidal effect occurs.

After entering the body, the drug is rapidly absorbed by the walls of the gastrointestinal tract. The main substance of josamycin accumulates in the tissue structures of the lungs, lymph, dermatological and urinary biosystems. The product is able to biotransform in the hepatic organ to little active metabolites. The chemical component is excreted from the body with urine and bile.

Composition and form of release

The structure of Vilprafen Solutab includes the compound josamycin. Also, the product is filled with microcrystalline cellulose, polysorbate, magnesium stearate, macrogol 6000 and other materials. The drug is available in the form of tablets. The product can be purchased in suspension form. Which type of product is more suitable for the patient, the doctor will determine.

Indications for use

The drug is used to treat tonsillitis, sinusitis, diphtheria, scarlet fever, pharyngitis, severe bronchitis, laryngitis, whooping cough. Also, the product is prescribed for infection of soft tissue structures, dermis, infection with bacterial forms, urinary, genital organs - prostatitis, gonorrhea, urethritis. Perhaps the introduction of tablets in case of infection of the oral cavity.

The appointment has the right to carry out the doctor, taking into account the individual characteristics of the body, information obtained as a result of a medical examination, the clinical picture of the disease. It is dangerous to take Vilprafen Solutab on your own, without a doctor's examination.

International Classification of Diseases (ICD-10)

A22 Carbuncle, malignant; A36.9 Diphtheria, type unspecified; A37 Pertussis; A38 Scarlet fever; A46 Erysipelas; A49.3 Mycoplasma infection, type unspecified; A53.9 Syphilis, type unspecified; A54.9 Gonococcal infection, type unspecified; A55 Chlamydial lymphogranuloma (venereal); A56 Other chlamydial pathologies that develop due to the penetration of bacteria into the genitals; A63.8 Other specified pathologies that develop due to the penetration of bacteria into the genital organs; A70 Chlamydia psittaci infection; A74.9 Chlamydia infection, type unspecified; H01.0 Inflammatory processes occurring in the structure of the eyelid; H04.3 Acute and unspecified inflammation of lacrimal passages; H66.9 Otitis media, type unspecified; I88 Nonspecific lymphadenitis; I89.1 Lymphangitis; J01 Acute sinusitis; J02.9 Acute pharyngitis, type unspecified; J03.9 Acute tonsillitis, type unspecified (tonsillitis, agranulocytic); J04.0 Acute laryngitis; J18 Pneumonia without specification of the pathogen; J20 Acute bronchitis; J31.2 Inflammation of the pharynx in a protracted form; J32 Inflammation of the paranasal sinuses in a protracted form; J37.0 Protracted laryngitis; J42 Protracted bronchitis, type unspecified; K05 Gingivitis and periodontal disease; L02 Dermal abscess, furuncle and carbuncle; L04 Acute lymphadenitis; L08.0 Pyoderma; L70 Acne; N34 Urethritis and urethral syndrome; N39.0 Infection of the urinary passages without an established focus of development; N41.0 Acute prostatitis; N41.1 Protracted prostatitis; N74.2 Inflammatory pathologies of female pelvic organs due to syphilis (A51.4+, A52.7+)

Side effects

When using the drug Vilprafen solutab, accidental symptoms often occur, manifested in the form of nausea, jaundice, diarrhea, certain types of colitis, and skin rashes. Sometimes there is a hearing loss. If you find these or other painful symptoms, you should immediately stop taking the tablets and consult a doctor. He will reduce the dosage, or change the therapy regimen.

Contraindications

Antimicrobial drugs can pose a danger to the human body. Therefore, they are used only after the appointment of a medical specialist. Otherwise, such therapy will lead to complications and the development of severe pathological processes. Before using the substance, a medical examination should be carried out. Before the introduction of tablets, it is recommended to study the instructions for the medication, its indications and contraindications. The list of the latter includes: severe dysfunctions of the hepatic organ, increased sensitivity of the immune mechanism to the chemical components of the product. In the presence of at least one of the above indications, it is prohibited to prescribe the remedy.

Application during pregnancy

It is not advisable to use an antibiotic of this group of medicines during gestation. It is prescribed in the most extreme cases, when the maximum benefit for the woman and the minimum risk of complications for the baby are expected. During this period, the pregnant patient should be under the supervision of a doctor.

Method and features of application

The tool can be taken by both adults and minors who are already 14 years old. Enter 1-2 tablets in several doses. The initial dosage should not exceed 1 g. To obtain good results in the treatment of chlamydia, it is recommended to take 500 mg of Vilprafen Solutaba 2 times every 24 hours for 2 weeks. As for the treatment of rosacea, in this case, they use 1000 mg, after dividing the drug into several doses. Course duration - no more than 10 days. The substance is allowed to be administered in various ways - taking a tablet form together with water, or after its preliminary dissolution in a liquid. Mix the resulting mixture well and drink immediately. The latter method is most often taken by people who have difficulty swallowing solid foods. Pills are not desirable to chew. The instruction indicates the need to use the product between meals. The josamycin compound is not prescribed to premature infants. It is possible to administer the drug to newborn babies. In this case, the work of the hepatic organization should be carefully monitored. A patient suffering from insufficient kidney function should pay attention to dosage adjustments. It needs to be aligned with the QC indicators. The drug is prohibited to prescribe in the presence of severe violations of the hepatic organ. How to administer pills to elderly people, the expert will point out.

Interaction with other drugs

Vilprafen solutab, as a substance with a bacteriostatic effect, is able to reduce the degree of this effect of other antimicrobial products. It is especially reflected in the influence of cephalosporin and penicillin compounds. If you enter the drug together with lincomycin, then there is a decrease in the effectiveness of both materials. Josamycin inhibits the elimination of theophylline, astemizole, terfenadine from the body. This combination can provoke a dangerous arrhythmia, which is often fatal. According to some reports, the drug is able to increase the vasoconstructive effect when interacting with ergot alkaloids. If Vilprafen Solutab is administered together with a cyclosporine compound, then an increase in the amount of the latter in the blood substance is possible, up to nephrotoxic manifestations. The doctor needs to be informed about the intake of pharmacological agents. Based on the information received from the patient, he will suggest the optimal therapy regimen.

Overdose

There is no information about taking overdoses of the drug Vilprafen Solutab. Medical specialists pay attention to the possibility of accidental reactions when a significant amount of the agent is introduced into the body. In case of overdose and the occurrence of painful symptoms, you should immediately stop using the substance and consult a doctor. He will prescribe the appropriate therapy.

Analogues

Means alternative to the product are not sold in pharmacies. Therefore, only a medical specialist can replace the drug. Based on the data obtained after the medical examination, clinical indications, information about the individual characteristics of the patient, the expert will change the treatment regimen and prescribe other medications. Substances similar in their actions belong to the group of macrolides. Among them, materials such as spiramycin, azithromycin, erythromycin and other antimicrobial chemical components are distinguished. The cost of products depends on many factors. The price of an analogue can be either less or more than Vilprafen Solutab. The drug without the second part of the name has some differences. First of all, we are talking about the form of release. It is a more simplified version - ordinary tablets, coated on top with a special shell. As for the additional word solutab, this type of medicine is a soluble substance with a pleasant taste and aroma. It is from them that it is very easy to prepare a suspension. In this case, all the rules of sterility should be followed.

Terms of sale

Vilprafen Solutab is sold by prescription from a doctor.

Storage conditions

The tool is included in list B. Instructions for use indicate the features of saving the product. It should be kept in a dark place that is not accessible to minors and sunlight. The temperature regime should not exceed 25°C. The product must not be frozen. Shelf life - 4 years from the date of release of the drug. If defects or other damage are found on the packaging, the tablets must be disposed of immediately.