Registration number: ПN015746/01
Trade name of the drug: Vitamin C
International nonproprietary name (INN) or generic name: Ascorbic acid
Dosage form: effervescent tablets
Compound
contains active substance: ascorbic acid 250 mg; Excipients: sodium bicarbonate, sodium carbonate, citric acid, sucrose, orange flavor, riboflavin sodium phosphate, sodium saccharinate, macrogol 6000, sodium benzoate, povidone K-30.
contains active substance: ascorbic acid 1000 mg; Excipients: sodium bicarbonate, sodium carbonate, citric acid, sorbitol, lemon flavor, sodium riboflavin phosphate, sodium saccharinate, macrogol 6000, sodium benzoate, povidone K-30.
Description
Round, flat-cylindrical tablets with a chamfer on both sides, with a rough surface, from pale yellow to yellow.
Pharmacotherapeutic group: Vitamin.
ATX code: A11GA01.
Ascorbic acid is a vitamin, has a metabolic effect, is not formed in the human body, and comes only with food. With an unbalanced and inadequate diet, a person experiences a deficiency in ascorbic acid.
Participates in the regulation of redox processes, carbohydrate metabolism, blood clotting, tissue regeneration; increases the body's resistance to infections, reduces vascular permeability, reduces the need for vitamins B1, B2, A, E, folic acid, pantothenic acid. Participates in the metabolism of phenylalanine, tyrosine, folic acid, norepinephrine, histamine, Fe, utilization of carbohydrates, synthesis of lipids, proteins, carnitine, immune reactions, hydroxylation of serotonin, enhances the absorption of non-heme Fe.
It has antiplatelet and pronounced antioxidant properties.
Regulates H+ transport in many biochemical reactions, improves the use of glucose in the tricarboxylic acid cycle, participates in the formation of tetrahydrofolic acid and tissue regeneration, the synthesis of steroid hormones, collagen, procollagen.
Maintains the colloidal state of the intercellular substance and normal capillary permeability (inhibits hyaluronidase).
Activates proteolytic enzymes, participates in the metabolism of aromatic amino acids, pigments and cholesterol, promotes the accumulation of glycogen in the liver. Due to the activation of respiratory enzymes in the liver, it enhances its detoxification and protein-forming functions, and increases the synthesis of prothrombin.
Improves bile secretion, restores exocrine function of the pancreas and endocrine function of the thyroid gland.
Regulates immunological reactions (activates the synthesis of antibodies, C3 component of complement, interferon), promotes phagocytosis, increases the body's resistance to infections.
Inhibits the release and accelerates the degradation of histamine, inhibits the formation of Pg and other mediators of inflammation and allergic reactions.
In low doses (150-250 mg/day orally) it improves the complexing function of deferoxamine in chronic intoxication with Fe preparations, which leads to increased excretion of the latter.
Absorbed in the gastrointestinal tract (GIT) (mainly in the jejunum). With an increase in dose to 200 mg, up to 140 mg (70%) is absorbed; with a further increase in dose, absorption decreases (50-20%). Communication with plasma proteins - 25%. Gastrointestinal diseases (peptic ulcer of the stomach and duodenum, constipation or diarrhea, helminthic infestation, giardiasis), consumption of fresh fruit and vegetable juices, alkaline drinking reduce the absorption of ascorbate in the intestines.
The normal concentration of ascorbic acid in plasma is approximately 10-20 mcg/ml, body reserves are about 1.5 g when taking daily recommended doses and 2.5 g when taking 200 mg/day, the time to reach maximum concentration after oral administration is 4 hours.
Easily penetrates into leukocytes, platelets, and then into all tissues; the highest concentration is achieved in the glandular organs, leukocytes, liver and lens of the eye; deposited in the posterior lobe of the pituitary gland, adrenal cortex, ocular epithelium, interstitial cells of the seminal glands, ovaries, liver, spleen, pancreas, lungs, kidneys, intestinal wall, heart, muscles, thyroid gland; penetrates the placenta. The concentration of ascorbic acid in leukocytes and platelets is higher than in erythrocytes and plasma. In deficiency states, leukocyte concentrations decline later and more slowly and are considered a better measure of deficiency than plasma concentrations.
Metabolized primarily in the liver into deoxyascorbic acid and further into oxaloacetic and diketogulonic acids.
It is excreted by the kidneys, through the intestines, with sweat, and breast milk in the form of unchanged ascorbate and metabolites.
When high doses are prescribed, the rate of elimination increases sharply. Smoking and drinking ethanol accelerate the destruction of ascorbic acid (conversion into inactive metabolites), sharply reducing reserves in the body.
Excreted during hemodialysis.
For tablets containing 1000 mg ascorbic acid:
Treatment of vitamin C deficiency.
For tablets containing 250 mg ascorbic acid:
Treatment and prevention of hypo- and avitaminosis C, including those caused by a state of increased need for ascorbic acid with:
- increased physical and mental stress;
- in complex therapy of colds, acute respiratory viral infections;
- for asthenic conditions;
- during the recovery period after illnesses.
- pregnancy (especially multiple pregnancy, against the background of nicotine or drug addiction).
Hypersensitivity to the components of the drug.
Children under 18 years of age (for this dosage form).
With long-term use in large doses (more than 500 mg): diabetes mellitus, hyperoxaluria, nephrolithiasis, hemochromatosis, thalassemia.
Diabetes mellitus, glucose-6-phosphate dehydrogenase deficiency, hemochromatosis, sideroblastic anemia, thalassemia, hyperoxaluria, oxalosis, kidney stones.
The minimum daily requirement for ascorbic acid in the second and third trimesters of pregnancy is about 60 mg. It should be borne in mind that the fetus can adapt to high doses of ascorbic acid taken by a pregnant woman, and then the newborn may develop a withdrawal syndrome.
The minimum daily requirement during lactation is 80 mg. A maternal diet containing adequate amounts of ascorbic acid is sufficient to prevent deficiency in the infant. Theoretically, there is a danger to the baby when the mother uses high doses of ascorbic acid (it is recommended that a nursing mother not exceed the daily requirement for ascorbic acid).
The drug is taken orally after meals. 1 tablet is dissolved in a glass of water (200 ml). The tablets should not be swallowed, chewed or dissolved in the mouth.
Treatment of vitamin C deficiency: 1000 mg per day.
Treatment and prevention of hypo- and vitamin deficiency C: 250 mg 1-2 times a day.
During pregnancy The drug is prescribed in a maximum daily dose of 250 mg for 10-15 days.
From the central nervous system (CNS): with long-term use of large doses (more than 1000 mg) - headache, increased excitability of the central nervous system, insomnia.
From the digestive system: irritation of the mucous membrane of the gastrointestinal tract (GIT), with long-term use of large doses - nausea, vomiting, diarrhea, hyperacid gastritis, ulceration of the mucous membrane of the gastrointestinal tract.
From the endocrine system: inhibition of the function of the insular apparatus of the pancreas (hyperglycemia, glycosuria).
From the urinary system: moderate pollakiuria (when taking a dose of more than 600 mg/day), with long-term use of large doses - hyperoxaluria, nephrolithiasis (from calcium oxalate), damage to the glomerular apparatus of the kidneys.
From the cardiovascular system: with long-term use of large doses - a decrease in capillary permeability (possible deterioration of tissue trophism, increased blood pressure, hypercoagulation, development of microangiopathies).
Allergic reactions: skin rash, skin hyperemia.
Laboratory indicators: thrombocytosis, hyperprothrombinemia, erythropenia, neutrophilic leukocytosis, hypokalemia.
Others: hypervitaminosis, metabolic disorders, feeling of heat, with prolonged use of large doses - sodium (Na+) and fluid retention, metabolic disorders of zinc and copper.
with long-term use of large doses (more than 1000 mg per day), nausea, heartburn, diarrhea, irritation of the gastrointestinal mucosa, flatulence, spastic abdominal pain, frequent urination, nephrolithiasis, insomnia, irritability, hypoglycemia are possible.
symptomatic, forced diuresis. If any side effects occur, you should stop taking the drug and consult a doctor.
Increases the concentration of benzylpenicillin and tetracyclines in the blood; at a dose of 1 g/day increases the bioavailability of ethinyl estradiol (including that included in oral contraceptives). Improves the absorption of iron preparations in the intestines (converts ferric iron to divalent iron), can increase the excretion of iron when used simultaneously with deferoxamine.
Reduces the effectiveness of heparin and indirect anticoagulants.
Acetylsalicylic acid (ASA), oral contraceptives, fresh juices and alkaline drinks reduce the absorption and absorption of ascorbic acid.
When used simultaneously with ASA, the urinary excretion of ascorbic acid increases and the excretion of ASA decreases. ASA reduces the absorption of ascorbic acid by approximately 30%.
Increases the risk of developing crystalluria during treatment with salicylates and short-acting sulfonamides, slows down the excretion of acids by the kidneys, increases the excretion of drugs that have an alkaline reaction (including alkaloids), and reduces the concentration of oral contraceptives in the blood.
Increases the overall clearance of ethanol, which, in turn, reduces the concentration of ascorbic acid in the body.
Quinoline drugs, calcium chloride, salicylates, and glucocorticosteroids deplete ascorbic acid reserves with long-term use.
When used simultaneously, it reduces the chronotropic effect of isoprenaline.
Long-term use or use in high doses may interfere with the disulfiram-ethanol interaction.
In high doses, it increases the excretion of mexiletine by the kidneys.
Barbiturates and primidone increase the excretion of ascorbic acid in the urine. Reduces the therapeutic effect of antipsychotic drugs (neuroleptics) - phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants.
Foods rich in ascorbic acid: citrus fruits, greens, vegetables (peppers, broccoli, cabbage, tomatoes, potatoes). When storing food (including long-term freezing, drying, salting, pickling), cooking (especially in copper utensils), chopping vegetables and fruits in salads, and preparing purees, ascorbic acid is partially destroyed (up to 30-50% during heat treatment).
Due to the stimulating effect of ascorbic acid on the synthesis of corticosteroid hormones, it is necessary to monitor adrenal function and blood pressure.
With long-term use of large doses, inhibition of the function of the pancreatic insular apparatus is possible, so it must be regularly monitored during treatment.
In patients with high iron levels in the body, ascorbic acid should be used in minimal doses.
Currently, the effectiveness of using ascorbic acid for the prevention of diseases of the cardiovascular system (CVS) and some types of malignant tumors is considered unproven.
Ascorbic acid is not recommended for use in cases of pyorrhea, infectious gum diseases, hemorrhagic phenomena, hematuria, hemorrhage in the retina, disorders of the immune system, depression not associated with vitamin C deficiency.
Prescribing ascorbic acid to patients with rapidly proliferating and intensively metastasizing tumors can aggravate the process.
Ascorbic acid as a reducing agent can distort the results of various laboratory tests (blood glucose, bilirubin, liver transaminase and LDH activity).
Ascorbic acid, or vitamin C, is an affordable product that can be easily purchased without a prescription at any pharmacy. Regular use protects the body from infections, stimulates metabolism and improves skin condition. A sufficient amount of vitamin enters the body with a balanced diet, but in winter, when there is a lack of fresh fruits and vegetables, the risk of hypovitaminosis C increases. In order to avoid this condition, you can buy vitamin tablets.
Ascorbic acid, or vitamin C, is an affordable product that can be easily purchased without a prescription at any pharmacy.
Release form: effervescent tablets, 20 pcs. packaged. 1 tablet contains 1 g of the active ingredient - vitamin C. Additional components: sodium carbonate, sodium saccharinate, sodium benzoate, sodium bicarbonate, povidone-K30, riboflavin sodium phosphate, macrogol 6000, sorbitol. Contains lemon flavor and citric acid.
Vitamin C affects redox reactions in cells. Has an antioxidant effect - neutralizes the effects of free radicals; activates metabolism, affects tissue regeneration.
The vitamin is vital for humans; it is not synthesized by the body itself; it comes with food - berries, fruits, vegetables, nuts. With a lack of the substance, scurvy develops - a disease characterized by fragility of blood vessels and a decrease in the protective forces of the immune system.
The presence of vitamin C promotes the synthesis of substances important for the body - it is involved in the formation of corticosteroids, collagen, and the neurotransmitter serotonin. It has an effect on the restoration of vitamin E and ubiquinone (coenzyme Q10). Ensures the absorption of glucose by cells.
The vitamin affects the functions of the immune system - it activates the synthesis of interferon. In the presence of ascorbic acid, a person’s need for vitamins A, B1, B2, E, folic and pantothenic acids is reduced.
With disorders of the digestive system, consumption of alkaline drinks, vegetable and fruit juices, the absorption and assimilation of the vitamin is reduced.
After administration, the maximum plasma concentration of the substance is observed after 4 hours. Normally, the amount of ascorbic acid in the blood is about 10-20 mcg/ml; when consuming recommended doses of the substance, approximately 1.5 g is stored per day. Drinking alcoholic beverages and smoking contribute to the destruction of vitamin C and reduce the reserves of the substance in the body.
Do not take if you are hypersensitive to any of the components in the composition.
When used over a long course and in large doses, the following diseases become contraindications: diabetes mellitus, kidney stones, oxalosis, Cooley's anemia, hemochromatosis. With these diagnoses, sideroblastic anemia and glucose-6-phosphate dehydrogenase deficiency, the vitamin should be used with caution, even if the minimum dosage is observed.
You should not swallow or dissolve the tablets - they are taken orally, after dissolving them in a glass of water. This should be done after eating.
For vitamin deficiency, the daily dose is 1000 mg (1 tablet).
Daily intake to prevent vitamin deficiency is 250 mg 1 or 2 times.
In case of hypersensitivity to the components, an allergic reaction may occur. Long-term use in large doses can lead to hypervitaminosis, metabolic disorders, insomnia and headaches, a feeling of heat, and stimulation of the central nervous system.
Irritation of the gastrointestinal mucosa, inhibition of pancreatic function, impaired renal function, and decreased vascular permeability may occur.
With prolonged use of the drug in an amount of more than 1 g per day, an overdose is possible. It is manifested by heartburn, nausea, diarrhea, flatulence, abdominal cramps, and irritation of the gastrointestinal mucosa. Urination becomes more frequent, the amount of sugar in the blood drops, problems with sleep are observed, and the person becomes more irritable.
Treatment of overdose consists of forced diuresis and treatment of symptoms.
Caution should be used for certain conditions.
The minimum required amount of vitamin during pregnancy is 60 mg, during breastfeeding – 80 mg.
When prescribing ascorbic acid to pregnant women, the dose does not exceed 250 mg per day, and the course of use lasts no more than 2 weeks.
Ascorbic acid in a dosage of 1 g per day is prohibited for use in childhood. Children should take lower dosages of vitamin C.
Combined use with acetylsalicylic acid and hormonal contraceptives reduces the absorption of vitamin C, and barbiturates accelerate its elimination.
Reduces the effect of isoprenaline, anticoagulants and some neuroleptics.
Long-term therapy with corticosteroids, salicylates, quinolones and calcium chloride reduces vitamin C reserves.
When consuming the vitamin, the blood level of oral contraceptives decreases, the excretion of acids slows down and the transport of drugs with an alkaline reaction accelerates. Increases the amount of salicylates in the blood, which can lead to the development of crystalluria. Improves the absorption of drugs containing iron in the intestines.
Storage temperature – +15…+25°C. Should be kept out of the reach of children. Protect from exposure to direct sunlight and high humidity. The tablets are suitable for use for 2 years from the date of manufacture.
Ascorbic acid.
No prescription required to purchase.
Absorbed in the gastrointestinal tract (GIT) (mainly in the jejunum). With an increase in dose to 200 mg, up to 140 mg (70%) is absorbed; with a further increase in dose, absorption decreases (50-20%). Communication with plasma proteins - 25%. Gastrointestinal diseases (peptic ulcer of the stomach and duodenum, constipation or diarrhea, helminthic infestation, giardiasis), consumption of fresh fruit and vegetable juices, alkaline drinking reduce the absorption of ascorbate in the intestines.
The normal concentration of ascorbic acid in plasma is approximately 10-20 mcg/ml, body reserves are about 1.5 g when taking daily recommended doses and 2.5 g when taking 200 mg/day, the time to reach maximum concentration after oral administration is 4 hours.
Easily penetrates into leukocytes, platelets, and then into all tissues; the highest concentration is achieved in the glandular organs, leukocytes, liver and lens of the eye; deposited in the posterior lobe of the pituitary gland, adrenal cortex, ocular epithelium, interstitial cells of the seminal glands, ovaries, liver, spleen, pancreas, lungs, kidneys, intestinal wall, heart, muscles, thyroid gland; penetrates the placenta. The concentration of ascorbic acid in leukocytes and platelets is higher than in erythrocytes and plasma. In deficiency states, leukocyte concentrations decline later and more slowly and are considered a better measure of deficiency than plasma concentrations.
Metabolized primarily in the liver into deoxyascorbic acid and further into oxaloacetic and diketogulonic acids.
It is excreted by the kidneys, through the intestines, with sweat, and breast milk in the form of unchanged ascorbate and metabolites.
When high doses are prescribed, the rate of elimination increases sharply. Smoking and drinking ethanol accelerate the destruction of ascorbic acid (conversion into inactive metabolites), sharply reducing reserves in the body.
Excreted during hemodialysis.
Symptoms: with long-term use of large doses (more than 1000 mg per day), nausea, heartburn, diarrhea, irritation of the gastrointestinal mucosa, flatulence, spastic abdominal pain, frequent urination, nephrolithiasis, insomnia, irritability, hypoglycemia are possible.
Treatment: symptomatic, forced diuresis. If any side effects occur, you should stop taking the drug and consult a doctor.
Store in a dry place, protected from light, at a temperature of 15 to 25 C.
Keep out of the reach of children!
Increases the concentration of benzylpenicillin and tetracyclines in the blood; at a dose of 1 g/day increases the bioavailability of ethinyl estradiol (including that included in oral contraceptives). Improves the absorption of iron preparations in the intestines (converts ferric iron to divalent iron), can increase the excretion of iron when used simultaneously with deferoxamine.
Reduces the effectiveness of heparin and indirect anticoagulants.
Acetylsalicylic acid (ASA), oral contraceptives, fresh juices and alkaline drinks reduce the absorption and absorption of ascorbic acid.
When used simultaneously with ASA, the urinary excretion of ascorbic acid increases and the excretion of ASA decreases. ASA reduces the absorption of ascorbic acid by approximately 30%.
Increases the risk of developing crystalluria during treatment with salicylates and short-acting sulfonamides, slows down the excretion of acids by the kidneys, increases the excretion of drugs that have an alkaline reaction (including alkaloids), and reduces the concentration of oral contraceptives in the blood.
Increases the overall clearance of ethanol, which, in turn, reduces the concentration of ascorbic acid in the body.
Quinoline drugs, calcium chloride, salicylates, and glucocorticosteroids deplete ascorbic acid reserves with long-term use.
When used simultaneously, it reduces the chronotropic effect of isoprenaline.
Long-term use or use in high doses may interfere with the disulfiram-ethanol interaction.
In high doses, it increases the excretion of mexiletine by the kidneys.
Barbiturates and primidone increase the excretion of ascorbic acid in the urine. Reduces the therapeutic effect of antipsychotic drugs (neuroleptics) - phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants.
From the central nervous system (CNS): with long-term use of large doses (more than 1000 mg) - headache, increased excitability of the central nervous system, insomnia.
From the digestive system: irritation of the mucous membrane of the gastrointestinal tract (GIT), with prolonged use of large doses - nausea, vomiting, diarrhea, hyperacid gastritis, ulceration of the mucous membrane of the gastrointestinal tract.
From the endocrine system: inhibition of the function of the insular apparatus of the pancreas (hyperglycemia, glycosuria).
From the urinary system: moderate pollakiuria (when taking a dose of more than 600 mg/day), with long-term use of large doses - hyperoxaluria, nephrolithiasis (from calcium oxalate), damage to the glomerular apparatus of the kidneys.
From the cardiovascular system: with long-term use of large doses - a decrease in capillary permeability (possible deterioration of tissue trophism, increased blood pressure, hypercoagulation, development of microangiopathies).
Allergic reactions: skin rash, skin hyperemia.
Laboratory indicators: thrombocytosis, hyperprothrombinemia, erythropenia, neutrophilic leukocytosis, hypokalemia.
Other: hypervitaminosis, metabolic disorders, feeling of heat, with prolonged use of large doses - sodium (Na+) and fluid retention, metabolic disorders of zinc and copper.
Active substance: ascorbic acid 1000.00 mg; excipients: sodium bicarbonate – 821.00 mg, sodium carbonate – 152.00 mg, citric acid – 1030.00 mg, sorbitol – 808.00 mg, lemon flavor – 75.00 mg, sodium riboflavin phosphate – 1.00 mg, sodium saccharinate – 5.00 mg, macrogol 6000 – 60.00 mg , sodium benzoate – 40.00 mg, povidone-K30 – 8.00 mg.
The drug is taken orally after meals. 1 tablet is dissolved in a glass of water (200 ml). The tablets should not be swallowed, chewed or dissolved in the mouth.
Treatment of vitamin C deficiency: 1000 mg per day.
Treatment and prevention of hypo- and avitaminosis C: 250 mg 1-2 times a day.
During pregnancy, the drug is prescribed at a maximum daily dose of 250 mg for 10-15 days.
Effervescent tablets
Carefully
Foods rich in ascorbic acid: citrus fruits, greens, vegetables (peppers, broccoli, cabbage, tomatoes, potatoes). When storing food (including long-term freezing, drying, salting, pickling), cooking (especially in copper utensils), chopping vegetables and fruits in salads, and preparing purees, ascorbic acid is partially destroyed (up to 30-50% during heat treatment).
Due to the stimulating effect of ascorbic acid on the synthesis of corticosteroid hormones, it is necessary to monitor adrenal function and blood pressure.
With long-term use of large doses, inhibition of the function of the pancreatic insular apparatus is possible, so it must be regularly monitored during treatment.
In patients with high iron levels in the body, ascorbic acid should be used in minimal doses.
Currently, the effectiveness of using ascorbic acid for the prevention of diseases of the cardiovascular system (CVS) and some types of malignant tumors is considered unproven.
Ascorbic acid is not recommended for use in cases of pyorrhea, infectious gum diseases, hemorrhagic phenomena, hematuria, hemorrhage in the retina, disorders of the immune system, depression not associated with vitamin C deficiency.
Prescribing ascorbic acid to patients with rapidly proliferating and intensively metastasizing tumors can aggravate the process.
Ascorbic acid as a reducing agent can distort the results of various laboratory tests (blood glucose, bilirubin, liver transaminase and LDH activity).
The minimum daily requirement for ascorbic acid in the II-III trimesters of pregnancy is about 60 mg. It should be borne in mind that the fetus can adapt to high doses of ascorbic acid taken by a pregnant woman, and then the newborn may develop a withdrawal syndrome. The minimum daily requirement during lactation is 80 mg. A maternal diet containing adequate amounts of ascorbic acid sufficient to prevent deficiency in an infant.Theoretically, there is a danger to the child when the mother uses high doses of ascorbic acid (it is recommended not to exceed the daily requirement for ascorbic acid for a nursing mother).
20 tablets per plastic tube, sealed with a plastic cap with silica gel and tamper evident. 1 tube along with instructions for use in a cardboard box.
Treatment of vitamin C deficiency.
Hypersensitivity to the components of the drug.
Children under 18 years of age (for this dosage form).
With long-term use in large doses (more than 500 mg): - diabetes mellitus, hyperoxaluria, nephrolithiasis, hemochromatosis, thalassemia.
Carefully
Diabetes mellitus, glucose-6-phosphate dehydrogenase deficiency; hemochromatosis, sideroblastic anemia, thalassemia, hyperoxaluria, oxalosis, kidney stones.
Ascorbic acid is a vitamin, has a metabolic effect, is not formed in the human body, and comes only with food. With an unbalanced and inadequate diet, a person experiences a deficiency in ascorbic acid.
Participates in the regulation of redox processes, carbohydrate metabolism, blood clotting, tissue regeneration; increases the body's resistance to infections, reduces vascular permeability, reduces the need for vitamins B1, B2, A, E, folic acid, pantothenic acid.
Participates in the metabolism of phenylalanine, tyrosine, folic acid, norepinephrine, histamine, Fe, utilization of carbohydrates, synthesis of lipids, proteins, carnitine, immune reactions, hydroxylation of serotonin, enhances the absorption of non-heme Fe.
It has antiplatelet and pronounced antioxidant properties.
Regulates H+ transport in many biochemical reactions, improves the use of glucose in the tricarboxylic acid cycle, participates in the formation of tetrahydrofolic acid and tissue regeneration, the synthesis of steroid hormones, collagen, procollagen.
Maintains the colloidal state of the intercellular substance and normal capillary permeability (inhibits hyaluronidase).
Activates proteolytic enzymes, participates in the metabolism of aromatic amino acids, pigments and cholesterol, promotes the accumulation of glycogen in the liver. Due to the activation of respiratory enzymes in the liver, it enhances its detoxification and protein-forming functions, and increases the synthesis of prothrombin.
Improves bile secretion, restores exocrine function of the pancreas and endocrine function of the thyroid gland.
Regulates immunological reactions (activates the synthesis of antibodies, C3 component of complement, interferon), promotes phagocytosis, increases the body's resistance to infections.
Inhibits the release and accelerates the degradation of histamine, inhibits the formation of Pg and other mediators of inflammation and allergic reactions.
In low doses (150-250 mg/day orally) it improves the complexing function of deferoxamine in chronic intoxication with Fe preparations, which leads to increased excretion of the latter.
The human body cannot exist normally without biologically active substances, which we call vitamins. Their role in metabolic processes is simply irreplaceable. They act as accelerators of many biochemical reactions, without which the growth and development of the body is simply impossible to imagine. Based on the ability of vitamins to dissolve in water or fat, they are divided into water-soluble and fat-soluble. Among water-soluble vitamins, the most famous are vitamins of group C.
In nature, vitamin C is represented by ascorbic acid, as well as its derivatives: dehydroascorbic acid and ascorbigen. The first derivative is formed due to the reduction of ascorbic acid with compounds containing sulfhydryl bonds. Ascorbigen is formed by adding amino acid or protein bases to ascorbic acid. All these modifications of vitamin C are highly soluble in water and have biological activity.
It is produced mainly in plants from glucose, most of which is represented by ascorbigen, since it is less susceptible to oxidative processes. Some animals are also able to provide themselves with this vitamin, but the human body must receive it from the outside. Accordingly, natural sources of this vitamin will be plant foods and some animal products, such as liver and kidneys, and fermented milk products.
The body's needs for ascorbic acid are significantly greater than for other vitamins, which is about 0.1 g per day. It is not always possible to fill this norm only with the usual foods that we are used to eating. To prevent vitamin deficiency, medications containing ascorbic acid are used. These can be multivitamin complexes or single preparations. Single-component medications containing vitamins C are available in various dosage forms. This can be powder in sachets, which is dissolved in warm water before use. One such bag costs about 12 rubles.
A person daily needs additional sources of vitamin substances, since unfavorable environmental living conditions, constant stress, and an irrational approach to nutrition negatively affect their absorption by the body. Because of this, internal organs and their systems cease to function normally. Vitamin C comes in several forms. According to scientific data, effervescent tablets are the best option, suitable not only for children, but also for adults.
Effervescent tablets are produced by a Serbian pharmaceutical company and distributed by a representative office in Croatia. The main active ingredient in the drug is ascorbic acid, which is a powerful antioxidant.
Effervescent vitamin C comes in tablets designed to be dissolved in liquid. They have a pale yellow or yellow tint and are chamfered on both sides. Their surface is rough. The drug is available in two versions. In one, the amount of ascorbic acid is 1000 mg, in the other - 250 mg. The tablets are offered packaged in tubes, which in turn are offered in cardboard boxes. One bottle contains 20 “pops”.
Excipients in the drug are:
Auxiliary elements in the composition of the tablets are aimed at enhancing the action of the main substance - ascorbic acid.
The main benefits of sour for adults and children are:
Despite the benefits of using vitamin C, you should consult your doctor before starting to take it. In any case, there are certain indications for its use, as well as contraindications that cannot be ignored.
The indication for prescribing a product containing 1000 mg of ascorbic acid is the need to eliminate the condition of hypovitaminosis of this element. A drug containing 250 mg of the substance has slightly more indications for prescription. These include:
In addition, it is important to take effervescent tablets for rheumatoid arthritis, as well as various bleedings, nasal, pulmonary, and uterine. Before starting use, it is important to consult with a specialist or study the instructions for use of the drug in detail.
Despite the enormous benefits of vitamin C, there are certain contraindications to its use in effervescent form. These include:
Long-term use of drugs is also contraindicated. For this reason, it is important that a specialist determine the exact number of days when they should be used. A repeated course of treatment is prescribed only after consulting a doctor.
It is recommended to use the medications after meals. Their minimum dosage per day is one tablet dissolved in 200 ml of liquid. It is strictly forbidden to dissolve fizzy drinks, keep them in the mouth for a long time, or chew them. If it is necessary to treat a condition caused by a lack of vitamin C, one tablet containing 1000 mg of the substance per day is prescribed. When preventing hypovitaminosis C, a drug is used with a dosage of the main element of 250 mg in the amount of one or two effervescent drinks.
During pregnancy, a woman needs more ascorbic acid, as the fetus also needs it. For this reason, experts prescribe taking effervescent tablets for ten to fifteen days. In this case, the dosage of ascorbic acid should not be higher than 250 mg. Why can't you take the drug constantly? The fetus may develop dependence on the beneficial substance, which is why development may be impaired after its withdrawal.
During lactation it is not recommended to use pharmaceutical drugs at all. It is much better to enrich a nursing woman’s diet with foods containing sufficient amounts of vitamin C. The amount of acidic vitamin per day for a nursing woman should not exceed 80 mg. Otherwise, the baby may develop an allergy to this substance.
Side effects usually occur when the dosage prescribed by the doctor is exceeded. These include:
If you have one or more of these symptoms, you should consult a specialist. Perhaps stopping the drugs will be enough to normalize the condition, however, there are often cases when an overdose becomes chronic and then symptomatic treatment is required.
It is worth noting that when using effervescent tablets, it is important to control your diet and reduce the amount of foods consumed: cabbage, citrus fruits, herbs, tomatoes, currants, potatoes. People who have an increased amount of iron in the blood should take the drug in a minimal amount. In addition, both forms of effervescent drinks should be used with caution when diseases such as:
Before taking laboratory tests, it is important not to take ascorbic acid, as its presence in the body can distort the results. For better preservation of drugs, it is important to store them correctly, that is, place them in dark places where children cannot reach. In this case, the air temperature in the room should not exceed 25°C.
Before you start using vitamin C tablets intended to be dissolved in water, you should notify your doctor if you are taking any medications. For example, its combined use with birth control pills will lead to an increase in the concentration of the latter in the blood. At the same time, the amount of the valuable substance in the body will decrease.
If “ascorbic acid” is taken together with aspirin, it is not absorbed in the stomach and is immediately excreted by the renal system. At the same time, the removal of aspirin from the human body slows down. It is advisable to take iron-containing preparations together with an acidic vitamin, as it has a beneficial effect on their absorption. You should not combine the intake of atropine, isoprenaline with vitamin C, as this will lead to rapid heartbeat.
It is known that the human body is not able to synthesize acidic vitamin on its own. For this reason, it is important to replenish its deficiency in a timely manner. Some begin to adjust their diet, enriching it with foods with a high content of ascorbic acid in them. However, there are often cases when this is not enough. That's when you have to resort to pharmaceutical drugs.
Experts used to prescribe the substance in tablets or syrup form, but recently everyone agrees that fizzy drinks are a better, more effective option. The advantages of using this form of vitamin release are:
It is known that the effervescent form of vitamin C is absorbed by the human body five times faster than the tablet form. In addition, it is absorbed much faster, which prevents it from causing harm to the mucous membrane of the gastrointestinal tract. For this reason, the drug is not contraindicated for people suffering from gastritis, gastric ulcers, and duodenal ulcers.
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The head of a small business can easily manage the budget independently. CHECKED! If you're budgeting...
The creation of new projects involves a preliminary economic justification for their feasibility, subsequent...
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The head of a small business can easily manage the budget independently. CHECKED! If you manage...
The creation of new projects involves a preliminary economic justification for their feasibility, subsequent...