Index: N10.11

Biomaterial: Blood with EDTA

Components of the complex: Amino acids (32 indicators): Alanine (ALA), Arginine (ARG), Aspartic acid (ASP), Citrulline (CIT), Glutamic acid (GLU), Glycine (GLY), Methionine (MET), Ornithine (ORN), Phenylalanine ( PHE), Tyrosine (TYR), Valine (VAL), Leucine (LEU), Isoleucine (ILEU), Hydroxyproline (HPRO), Serine (SER), Asparagine (ASN), a-aminoadipic acid (AAA), Glutamine ( GLN), b-alanine (BALA), Taurine (TAU), Histidine (HIS), Threonine (THRE), 1-methylhistidine (1MHIS), 3-methylhistidine (3MHIS), y-aminobutyric acid (GABA), b -aminoisobutyric acid (BAIBA), a-aminobutyric acid (AABA), Proline (PRO), Cystathionine (CYST), Lysine (LYS), Cystine (CYS), Cysteine ​​acid (CYSA) - in the blood.

Amino acids are organic substances containing carboxyl and amine groups. In the human body they are divided into replaceable and irreplaceable. Essential amino acids - tryptophan, valine, threonine, arginine, histidine, isoleucine, lysine, leucine, methionine, phenylalanine. Replaceable - proline, glycine, alanine, aspartate, glutamate, asparagine, glutamine, tyrosine, serine, cysteine. Proteinogenic and non-standard amino acids are amino acids whose metabolites take part in various metabolic processes in the body. Pathology of enzymes at any stage of transformation of substances can lead to the accumulation of amino acids and their transformation products, thereby having a negative impact on homeostasis.

When amino acid metabolism is disrupted, it can be either a primary manifestation (congenital) or a secondary manifestation (acquired). The clinical manifestations of these pathological conditions are varied, but early diagnosis and timely treatment can prevent the development and progression of symptoms of the disease.

This study helps in a comprehensive assessment of the concentration of standard and non-proteinogenic amino acids and their derivatives in the blood, and also helps determine the state of amino acid metabolism in the human body.

The results of this study can be used for various purposes, most often in diagnosing hereditary and acquired diseases that are associated with the process of impaired amino acid metabolism, differential diagnosis of the causes of nitrogen metabolism disorders, monitoring diet therapy and monitoring the effectiveness of treatment, assessing nutritional status and changes in diet.

An increase in the total amount of amino acids in the body can lead to: eclampsia, impaired fructose tolerance, diabetic ketoacidosis, renal failure, Reye's syndrome.

A decrease in the total concentration of amino acids includes such reasons as: hyperfunction of the adrenal cortex, prolonged fever, Hartnup's disease, Huntington's chorea, inadequate nutrition, namely fasting, malabsorption syndrome in severe diseases of the gastrointestinal tract, hypovitaminosis, nephrotic syndrome and rheumatoid arthritis

Clinical manifestations in primary aminoacidopathies vary depending on the amino acid affected.

An increase in arginine and glutamine is manifested by arginase deficiency. An increase in arginine succinate and glutamine – arginosuccinase deficiency.

As well as an increase in citrulline, glutamine (citrullinemia), cystine, isoleucine (maple syrup disease), valine, lysine (cystinuria), ornithine, leucine, in other words - leucinosis).

An increase in the concentration of phenylalanine leads to phenylketonuria, and an increase in tyrosine leads to tyrosinemia.

Secondary aminoacidopathies are characterized by the following manifestations:

Increased glutamine – hyperammonemia. Increased concentration of the amino acid alanine– lactic acidosis or, as it is also called, lactic acidosis.

Violation of glycine concentration leads to organic aciduria, also pathologically high levels of tyrosine are a consequence transient tyrosinemia in newborns.

• The optimal time for the blood collection procedure is from 8:00 to 11:00.
• The day before the test, adhere to your established daily diet. Excessive consumption of foods of one type is not recommended: only meat, only vegetables, etc.
• 24 hours before blood collection, exclude:
• - physical and emotional overload; air travel; temperature effects (visiting baths and saunas, hypothermia, etc.); violation of the sleep-wake pattern;
• - alcohol consumption;
• - taking dietary supplements;
• - instrumental medical examinations (ultrasound, x-ray, etc.) or procedures (physiotherapy, massage, etc.).
• At least 12 hours (but no more than 14 hours) before taking blood, refrain from eating and drinking, with the exception of drinking water. The last meal before taking blood is light.
• Do not smoke 1 hour before taking blood.
• Before drawing blood, you must remain at rest for at least 20 minutes.
• When preparing to draw blood while on medication, taking or stopping medications should be discussed with your doctor.

Amino acids is a fundamental part of proteins or proteins. When their indicators are normal, then all processes in the body proceed normally. The analysis is carried out for 32 indicators by drawing blood; urine can also serve as a biomaterial for this analysis. Blood is donated on an empty stomach.

Reasons for prescribing amino acid analysis.

• Monitoring the normal functioning of all body systems.
• For a more accurate diagnosis of diseases associated with impaired amino acid metabolism.

Norms of amino acids in the blood in µmol/l for adults.

What are amino acids responsible for?

Amino acids activate mental activity, improve memory, and activate metabolism. The endocrine system also cannot function normally without amino acids. Exceeding the boundaries of certain norms indicates serious diseases, most often of the liver and kidneys. The human body is able to synthesize half of the above amino acids on its own; the rest must come from outside along with food. The human need for each amino acid is small and amounts to 0.5-2 grams per day. The exclusion of any amino acid from the diet entails a disruption of the fragile balance of metabolic processes in our body.

4150.00 rub.

Service cost: Rostov-on-Don

Taking biomaterial is paid additionally

Taking blood from a peripheral vein: 130.00 rub.

99-10-115. Amino acids and acylcarnitines in the blood (42 indicators, HPLC-MS method)

Nomenclature of the Ministry of Health of the Russian Federation (Order No. 804n): B03.016.019.003 "Complex determination of amino acid concentrations (42 indicators) by high performance liquid chromatography in the blood"

Biomaterial: Blood EDTA

Completion time (in the laboratory): 5 w.d. *

Description

Depending on the possibility of synthesis in the body, there are nonessential and essential amino acids. Essential amino acids include: arginine, valine, isoleucine, leucine, methionine, phenylalanine. Essential amino acids include: alanine, aspartic acid, glycine, glutamic acid, tyrosine. If enzymes are defective at different stages of transformation, an accumulation of amino acids and their transformation products may occur and have a negative effect on the body. There are primary (congenital) and secondary (acquired) disorders of amino acid metabolism. Congenital diseases are caused by a deficiency of enzymes and/or transport proteins that are associated with the metabolism of amino acids. Acquired amino acid disorders are associated with diseases of the liver, gastrointestinal tract, kidneys, insufficient or inadequate nutrition, and neoplasms.

The study helps determine the level of amino acids in the blood, their derivatives, and assess the state of amino acid metabolism. An insufficient amount of any amino acid or acylcarnitine in the diet can lead to disruption of redox processes in the body, which can lead to disorders of the central nervous system. Muscle weakness and other pathological conditions are also possible. Tests for acylcarnitines allow you to determine metabolic disorders of organic and fatty acids.

This study includes 42 indicators:

• 3-Hydroxybutyrylcarnitine (C4OH)
• 3-Hydroxyisovalerylcarnitine (C5OH)
• 3-Hydroxymyristoylcarnitine (C14OH)
• 3-hydroxyoctadecanoylcarnitine (3-hydroxystearoyl, C18OH)
• 3-Hydroxyoctadecenoylcarnitine (3-hydroxyoleyl, C18:1OH)
• 3-Hydroxypalmitoylcarnitine (C16OH)
• 3-Hydroxypalmitoleylcarnitine (C16:1OH)
• L-carnitine free
• Alanine (Ala)
• Arginine (Arg)
• Acetylcarnitine (C2)
• Butyrylcarnitine (C4)
• Valin
• Hexadecenoylcarnitine (C16:1)
• Hexanoylcarnitine (C6)
• Glycine (Gly)
• Decanoylcarnitine (C10)
• Decenoylcarnitine (C10:1)
• Dodecanoylcarnitine (Lauroyl, C12)
• Isovalerylcarnitine (C5)
• Leucine+Isoleucine (Xle)
• Methionine (Met)
• Myristoylcarnitine (Tetradecanoyl, C14)
• Myristoleylcarnitine (Tetradecenoyl, C14:1)
• Octadecanoylcarnitine (Stearoyl, C18)
• Octadecenoylcarnitine (Oleyl, C18:1)
• Octanoylcarnitine (C8)
• Octenoylcarnitine (C8:1)
• Ornithine (Orn)
• Hexadecanoylcarnitine (C16)
• Propionylcarnitine (C3)
• Tetradecadienoylcarnitine (C14:2)
• Tiglilcarnitine (C5:1)
• Tyrosine (Tyr)
• Phenylalanine (Phe)
• Citrulline (Cit)
• 3-Hydroxyhexanoylcarnitine (C6OH)
• Decadienonoylcarnitine (C10:2)
• Dodecenoylcarnitine (C12:1)
• Proline (Pro)
• Adipylcarnitine (C6DC)
• Linoleylcarnitine (C18:2)

Indications for use

• confirmation of diseases that are caused by impaired metabolism of amino acids and acylcarnitines in the body;
• diagnostics of all organs and systems of the body.

Preparing for the study

Interpretation of results/Information for specialists

Interpretation of the results is carried out taking into account age, nutritional characteristics, clinical condition and other laboratory data indicators.
Increasing reference values: eclampsia; impaired fructose tolerance; diabetic ketoacidosis; renal failure; Reye's syndrome.
Reduction of reference values: hyperfunction of the adrenal cortex; fever; Hartnup's disease; Huntington's chorea; inadequate nutrition, fasting (kwashiorkor); malabsorption syndrome in severe diseases of the gastrointestinal tract; hypovitaminosis; nephrotic syndrome; pappataci fever (mosquito, phlebotomy); rheumatoid arthritis.

Most often ordered with this service

* The website indicates the maximum possible period for completing the study. It reflects the time it takes to complete the study in the laboratory and does not include the time for delivery of the biomaterial to the laboratory.
The information provided is for reference only and is not a public offer. For up-to-date information, contact the Contractor's medical center or call center.

Amino acids- these are organic compounds that are building materials for proteins and muscle tissue. Disorders of amino acid metabolism are the cause of many diseases (liver and kidneys). Amino acid analysis (urine and blood) is the primary means of assessing dietary protein absorption as well as metabolic imbalances that underlie many chronic disorders.

Composition of the study:

• 1-methylhistidine (1MHIS).
• 3-methylhistidine (3MHIS).
• a-aminoadipic acid (AAA).
• a-aminobutyric acid (AABA).
• b-alanine (BALA).
• b-aminoisobutyric acid (BAIBA).
• y-aminobutyric acid (GABA).
• Alanine (Ala).
• Arginine (Arg).
• Asparagine (ASN).
• Aspartic acid (Asp).
• Valin (Val).
• Hydroxyproline (HPRO).
• Histidine (HIS).
• Glycine (Gly).
• Glutamine (GLN).
• Glutamic acid (Glu).
• Isoleucine (ILEU).
• Leucine (LEU).
• Lysine (LYS).
• Methionine (Met).
• Ornithine (Orn).
• Proline (PRO).
• Serine (SER).
• Taurine (TAU).
• Tyrosine (Tyr).
• Threonine (THRE).
• Phenylalanine (Phe).
• Cystathionine (CYST).
• Cysteinic acid (CYSA).
• Cystine (CYS).
• Citrulline (Cit).

Arginine- is a conditionally replaceable amino acid, that is, it must constantly be supplied to the body with food. Arginine is involved in the production of nitric oxide, helps accelerate the synthesis of growth hormone and other hormones, accelerates healing and strengthens blood vessels. It is present in the body in free form and as part of proteins. Arginine underlies the synthesis of ornithine.

Ornithine- stimulates the release of insulin and growth hormone. It helps protect the liver from the effects of toxic substances, and also stimulates the regeneration and restoration of liver cells. The extremely important role of ornithine is associated with its participation in the urinary cycle, which is necessary for the excretion of ammonia. Ammonia is formed during the breakdown of proteins and is a toxic substance for the body. Ornithine is involved in its processing to form urea. Urea also has a toxic effect and increases nervous excitability. Thanks to ornithine, these toxins are eliminated from the body.

Aspartic acid- participates in transamination reactions and the urea cycle.

Citrulline- stimulates ammonia detoxification, supports immunity. It plays an important role in the metabolic processes of the body.

Glutamic acid- affects the absorption of calcium, carbohydrate metabolism and is an important neurotransmitter.

Glycine- regulates metabolism, improves brain activity.

Meteonine- prevents the deposition of fats on the walls of blood vessels and in the liver, improves digestion, protects the body from the effects of toxic substances and radiation.

Phenylalanine- participates in the formation of neurotransmitters, norepinephrine and dopamine, improves mental activity, normalizes appetite.

Tyrosine- normalizes the activity of the pituitary gland, thyroid gland, adrenal glands, norepinephrine and dopamine are synthesized from it.

Valin- regulates muscle activity, regenerates damaged tissue. Necessary for maintaining normal nitrogen metabolism in the body, can be used by muscles as a source of energy.

Leucine and isoleucine- participate in the restoration processes of bones, muscles, skin, activate the production of growth hormone, reduce blood sugar levels and are sources of energy. Decreased concentration: acute starvation, hyperinsulinism, hepatic encephalopathy. Increased concentration: ketoaciduria, obesity, fasting, viral hepatitis.

Hydroxyproline- found in the tissues of almost the entire body, it is part of collagen, which accounts for most of the protein in the body of mammals. Hydroxyproline synthesis is impaired in vitamin C deficiency.

Increased concentration: hydroxyprolinemia, uremia, liver cirrhosis.

Serin- belongs to the group of non-essential amino acids, participates in the formation of active centers of a number of enzymes, ensuring their function. Important in the biosynthesis of other non-essential amino acids: glycine, cysteine, methionine, tryptophan. Serine is the initial product of the synthesis of purine and pyrimidine bases, sphingolipids, ethanolamine, and other important metabolic products.

Decreased concentration: phosphoglycerate dehydrogenase deficiency, gout. Increased serine concentration: protein intolerance. Urine - burns, Hartnup's disease.

Asparagine- necessary to maintain balance in the processes occurring in the central nervous system; prevents both excessive excitation and excessive inhibition, participates in the processes of amino acid synthesis in the liver. Increased concentration: burns, Hartnup disease, cystinosis.

Alpha-aminoadipic acid- metabolite of the main biochemical pathways of lysine. Increased concentration: hyperlysinemia, alpha-aminoadipic aciduria, alpha-ketoadipic aciduria, Reye's syndrome.

Glutamine- performs a number of vital functions in the body: participates in the synthesis of amino acids, carbohydrates, nucleic acids, cAMP and c-GMP, folic acid, enzymes that carry out redox reactions (NAD), serotonin, n-aminobenzoic acid; neutralizes ammonia; converted to aminobutyric acid (GABA); is able to increase the permeability of muscle cells to potassium ions.

Decreased glutamine concentration: rheumatoid arthritis

Increased concentration: blood - hyperammonemia caused by the following reasons: hepatic coma, Reye's syndrome, meningitis, cerebral hemorrhage, urea cycle defects, deficiency of ornithine transcarbamylase, carbamoyl phosphate synthase, citrullinemia, arginine succinic aciduria, hyperornithinemia, hyperammonemia, homocitrullinemia (HHH syndrome), in some cases hyperlysemia type 1, lysinuric protein intolerance. Urine - Hartnup disease, generalized aminoaciduria, rheumatoid arthritis.

Beta-alanine- is the only beta amino acid, formed from dihydrouracil and carnosine. Increased concentration: hyper-β-alaninemia.

Taurine- promote the emulsification of fats in the intestines, has anticonvulsant activity, has a cardiotropic effect, improves energy processes, stimulates reparative processes in dystrophic diseases and processes accompanied by metabolic disorders of eye tissue, helps to normalize the function of cell membranes and improve metabolic processes.

Decreased taurine concentration: blood - manic-depressive syndrome, depressive neuroses.

Increased taurine concentration: urine - sepsis, hyper-β-alaninemia, folic acid deficiency (B 9), first trimester of pregnancy, burns.

Histidine- is part of the active centers of many enzymes and is a precursor in the biosynthesis of histamine. Promotes tissue growth and repair. Contained in large quantities in hemoglobin; used in the treatment of rheumatoid arthritis, allergies, ulcers and anemia. A lack of histidine can cause hearing loss.

Decreased histidine concentration: rheumatoid arthritis. Increased histidine concentration: histidinemia, pregnancy, Hartnup disease, generalized aminoaciduria.

Threonine is an essential amino acid that helps maintain normal protein metabolism in the body, is important for the synthesis of collagen and elastin, helps the liver, participates in fat metabolism, and stimulates the immune system.

Decreased threonine concentration: chronic renal failure, rheumatoid arthritis. Increased threonine concentration: Hartnup disease, pregnancy, burns, hepatolenticular degeneration.

1-methylhistidine is the main derivative of anserine. The enzyme carnosinase converts anserine into β-alanine and 1-methylhistidine. High levels of 1-methylhistidine tend to inhibit the enzyme carnosinase and increase anserine concentrations. Decreased carnosinase activity also occurs in patients with Parkinson's disease, multiple sclerosis, and post-stroke patients. Vitamin E deficiency can lead to 1-methylhistidinuria due to increased oxidative effects in skeletal muscle.

Increased concentration: chronic renal failure, meat diet.

3-methylhistidine is an indicator of the level of protein breakdown in muscles.

Decreased concentration: fasting, diet. Increased concentration: chronic renal failure, burns, multiple injuries.

Gamma-aminobutyric acid- found in the central nervous system and takes part in neurotransmitter and metabolic processes in the brain. GABA receptor ligands are considered as potential agents for the treatment of various mental and central nervous system disorders, which include Parkinson’s and Alzheimer’s diseases, sleep disorders (insomnia, narcolepsy), and epilepsy. Under the influence of GABA, the energy processes of the brain are also activated, the respiratory activity of tissues increases, the utilization of glucose by the brain improves, and blood supply improves.

Beta-aminoisobutyric (β)- aminoisobutyric acid is a non-protein amino acid, which is a product of the catabolism of thymine and valine. Increased concentration: various types of neoplasms, diseases accompanied by increased destruction of nucleic acids in tissues, Down syndrome, protein malnutrition, hyper-beta-alaninemia, beta-aminoisobutyric aciduria, lead poisoning.

Alpha-aminobutyric (α)- aminobutyric acid is the main intermediate product of the biosynthesis of ophthalmic acid. Increased concentration: nonspecific aminoaciduria, fasting.

Proline- one of twenty proteinogenic amino acids, is part of all proteins of all organisms.

Decreased concentration: Huntington's chorea, burns.

Increased concentration: blood - hyperprolinemia type 1 (proline oxidase deficiency), hyperprolinemia type 2 (pyrroline-5-carboxylate dehydrogenase deficiency), protein deficiency in newborns. Urine - hyperproliemia types 1 and 2, Joseph's syndrome (severe prolinuria), carcinoid syndrome, iminoglycinuria, Wilson-Konovalov disease (hepatolenticular degeneration).

Cystathionine- sulfur-containing amino acid, participates in the biosynthesis of cysteine, methionine and serine.

Lysine- this is an essential amino acid, which is part of almost any proteins, is necessary for growth, tissue repair, the production of antibodies, hormones, enzymes, albumins, has an antiviral effect, maintains energy levels, is involved in the formation of collagen and tissue repair, improves the absorption of calcium from the blood and its transport into bone tissue.

Decreased concentration: carcinoid syndrome, lysinuric protein intolerance.

Increased concentrations: blood - hyperlysinemia, glutaric acidemia type 2. Urine - cystinuria, hyperlysinemia, first trimester of pregnancy, burns.

Cystine in the body- is an important part of proteins such as immunoglobulins, insulin and somatostatin, strengthens connective tissue. Decreased cystine concentration: protein starvation, burns. Increased cystine concentrations: blood - sepsis, chronic renal failure. Urine - cystinosis, cystinuria, cystinlysinuria, first trimester of pregnancy.

Cysteinic acid- sulfur-containing amino acid. Intermediate product of cysteine ​​and cystine metabolism. Takes part in transamination reactions and is one of the precursors of taurine.

Only half of the necessary amino acids are synthesized in the human body, and the remaining amino acids - essential (arginine, valine, histidine, isoleucine, leucine, lysine, methionine, threonine, tryptophan, phenylalanine) - must come from food. The exclusion of any essential amino acid from the diet leads to the development of a negative nitrogen balance, clinically manifested by dysfunction of the nervous system, muscle weakness and other signs of metabolic and energy pathology.

It is impossible to overestimate the role of amino acids in the functioning of the body.

Indications:

• diagnosis of hereditary and acquired diseases associated with disorders of amino acid metabolism;
• differential diagnosis of the causes of disorders of nitrogen metabolism, removal of ammonia from the body;
• monitoring compliance with diet therapy and treatment effectiveness;
• nutritional status assessment and dietary modification.

Collect a strictly morning portion of urine, excreted immediately after sleep. Before collecting urine, it is necessary to perform a thorough hygienic toilet of the external genitalia. When urinating for the first time in the morning, release a small amount of urine (the first 1-2 seconds) into the toilet, then collect the entire portion of urine in a clean container without interrupting urination. Pour approximately 50 ml of urine into a sterile plastic container with a screw cap. When collecting urine, it is advisable not to touch the container to your body. It is necessary to deliver the container with urine to the medical office as soon as possible from the moment the biomaterial is taken.

Interpretation of results
Interpretation of results is carried out taking into account age, nutritional habits, clinical condition and other laboratory data.
Units of measurement - µmol/l.

1. 1-Methylhistidine

• <= 1 года: 17–419
• > 1 year before< 3 лет: 18–1629
• >= 3 years up<= 6 лет: 10–1476
• > 6 years up to<= 8 лет: 19–1435
• > 8 years up< 18 лет: 12–1549
• >= 18 years: 23–1339

• <= 1 года: 88–350
• > 1 year before< 3 лет: 86–330
• >= 3 years up<= 6 лет: 56–316
• > 6 years up to<= 8 лет: 77–260
• > 8 years up< 18 лет: 47–262
• >= 18 years: 70–246

• <= 30 дней: 0–299,7
• > 30 days before< 2 лет: 0–403,1
• >= 2 years before<= 11 лет: 0–211,1
• > 11 years up<= 17 лет: 0–167
• > 17 years: 0–146.7

• <= 1 года: 0–63
• > 1 year before< 3 лет: 0–56
• >= 3 years up<= 6 лет: 0–38
• > 6 years up to<= 8 лет: 0–30
• > 8 years up< 18 лет: 0–31
• >= 18 years: 0–19

• <= 1 года: 0–219
• > 1 year before< 3 лет: 0–92
• >= 3 years up<= 6 лет: 0–25
• > 6 years up to<= 8 лет: 0–25
• > 8 years up< 18 лет: 0–49
• >= 18 years: 0–52

• <= 1 года: 18–3137
• > 1 year before< 3 лет: 0–980
• >= 3 years up<= 6 лет: 15–1039
• > 6 years up to<= 8 лет: 24–511
• > 8 years up< 18 лет: 11–286
• >= 18 years: 0–301

• <= 1 года: 0–25
• > 1 year before< 3 лет: 0–13
• >= 3 years up<= 6 лет: 0–11
• > 6 years up to<= 8 лет: 0–6
• > 8 years up< 18 лет: 0–5
• >= 18 years: 0–5

• <= 1 года: 93–3007
• > 1 year before< 3 лет: 101–1500
• >= 3 years up<= 6 лет: 64–1299
• > 6 years up to<= 8 лет: 44–814
• > 8 years up< 18 лет: 51–696
• >= 18 years: 56–518

• <= 1 года: 10–560
• > 1 year before< 3 лет: 20–395
• >= 3 years up<= 6 лет: 14–240
• > 6 years up to<= 8 лет: 0–134
• > 8 years up< 18 лет: 0–153
• >= 18 years: 0–114

• <= 30 дней: 0–2100,3
• > 30 days before< 2 лет: 0–1328,9
• >= 2 years before<= 11 лет: 0–687,8
• > 11 years up<= 17 лет: 0–913,9
• > 17 years: 0–454.2

• <= 1 года: 0–64
• > 1 year before< 3 лет: 0–56
• >= 3 years up<= 6 лет: 0–30
• > 6 years up to<= 8 лет: 0–9
• > 8 years up< 18 лет: 0–11
• >= 18 years: 0–10

• <= 1 года: 11–211
• > 1 year before< 3 лет: 11–211
• >= 3 years up<= 6 лет: 0–139
• > 6 years up to<= 8 лет: 16–91
• > 8 years up< 18 лет: 0–75
• >= 18 years: 11–61

• <= 1 года: 0–2536
• > 1 year before< 3 лет: 0–89
• >= 3 years up<= 6 лет: 0–46
• > 6 years up to<= 8 лет: 0–19
• > 8 years up< 18 лет: 0–22
• >= 18 years: 0–15

• <= 1 года: 145–3833
• > 1 year before< 3 лет: 427–3398
• >= 3 years up<= 6 лет: 230–2635
• > 6 years up to<= 8 лет: 268–2147
• > 8 years up< 18 лет: 134–1983
• >= 18 years: 81–1128

• <= 1 года: 362–18614
• > 1 year before< 3 лет: 627–6914
• >= 3 years up<= 6 лет: 412–5705
• > 6 years up to<= 8 лет: 449–4492
• > 8 years up< 18 лет: 316–4249
• >= 18 years: 229–2989

• <= 30 дней: 0–2279,4
• > 30 days before< 2 лет: 0–4544,3
• >= 2 years before<= 11 лет: 0–1920,6
• > 11 years up<= 17 лет: 0–822
• > 17 years: 0–1756.2

• <= 1 года: 0–243
• > 1 year before< 3 лет: 12–128
• >= 3 years up<= 6 лет: 0–76
• > 6 years up to<= 8 лет: 0–39
• > 8 years up< 18 лет: 0–62
• >= 18 years: 0–34

• <= 1 года: 0–86
• > 1 year before< 3 лет: 0–78
• >= 3 years up<= 6 лет: 0–62
• > 6 years up to<= 8 лет: 0–34
• > 8 years up< 18 лет: 0–28
• >= 18 years: 0–22

• <= 1 года: 0–200
• > 1 year before< 3 лет: 15–167
• >= 3 years up<= 6 лет: 12–100
• > 6 years up to<= 8 лет: 13–73
• > 8 years up< 18 лет: 0–62
• >= 18 years: 0–51

• <= 1 года: 19–1988
• > 1 year before< 3 лет: 25–743
• >= 3 years up<= 6 лет: 14–307
• > 6 years up to<= 8 лет: 17–276
• > 8 years up< 18 лет: 10–240
• >= 18 years: 15–271

• <= 1 года: 0–41
• > 1 year before< 3 лет: 0–41
• >= 3 years up<= 6 лет: 0–25
• > 6 years up to<= 8 лет: 0–23
• > 8 years up< 18 лет: 0–20
• >= 18 years: 0–16

• <= 1 года: 0–265
• > 1 year before< 3 лет: 0–70
• >= 3 years up<= 6 лет: 0–44
• > 6 years up to<= 8 лет: 0–17
• > 8 years up< 18 лет: 0–18
• >= 18 years: 0–25

• <= 1 года: 28–2029
• > 1 year before< 3 лет: 0–119
• >= 3 years up<= 6 лет: 0–78
• > 6 years up to<= 8 лет: 0–20
• > 8 years up< 18 лет: 0–28
• >= 18 years: 0–26

• <= 1 года: 18–4483
• > 1 year before< 3 лет: 284–1959
• >= 3 years up<= 6 лет: 179–1285
• > 6 years up to<= 8 лет: 153–765
• > 8 years up< 18 лет: 105–846
• >= 18 years: 97–540

• <= 1 года: 37–8300
• > 1 year before< 3 лет: 64–3255
• >= 3 years up<= 6 лет: 76–3519
• > 6 years up to<= 8 лет: 50–2051
• > 8 years up< 18 лет: 57–2235
• >= 18 years: 24–1531

• <= 1 года: 39–685
• > 1 year before< 3 лет: 38–479
• >= 3 years up<= 6 лет: 23–254
• > 6 years up to<= 8 лет: 22–245
• > 8 years up< 18 лет: 12–208
• >= 18 years: 15–115

• <= 1 года: 25–1217
• > 1 year before< 3 лет: 55–763
• >= 3 years up<= 6 лет: 30–554
• > 6 years up to<= 8 лет: 25–456
• > 8 years up< 18 лет: 37–418
• >= 18 years: 31–278

• <= 1 года: 14–315
• > 1 year before< 3 лет: 14–315
• >= 3 years up<= 6 лет: 10–303
• > 6 years up to<= 8 лет: 10–303
• > 8 years up< 18 лет: 15–229
• >= 18 years old: 18–114

• <= 1 года: 14–280
• > 1 year before< 3 лет: 34–254
• >= 3 years up<= 6 лет: 20–150
• > 6 years up to<= 8 лет: 21–106
• > 8 years up< 18 лет: 11–111
• >= 18 years: 13–70

• <= 1 года: 0–302
• > 1 year before< 3 лет: 0–56
• >= 3 years up<= 6 лет: 0–26
• > 6 years up to<= 8 лет: 0–18
• > 8 years up< 18 лет: 0–44
• >= 18 years: 0–30

• <= 1 года: 12–504
• > 1 year before< 3 лет: 11–133
• >= 3 years up<= 6 лет: 0–130
• > 6 years up to<= 8 лет: 0–56
• > 8 years up< 18 лет: 0–104
• >= 18 years: 10–98

• <= 1 года: 0–72
• > 1 year before< 3 лет: 0–57
• >= 3 years up<= 6 лет: 0–14
• > 6 years up to<= 8 лет: 0–9
• > 8 years up< 18 лет: 0–14
• >= 18 years: 0–12

• eclampsia;
• impaired fructose tolerance;
• diabetic ketoacidosis;
• renal failure;
• Reye's syndrome.

• hyperfunction of the adrenal cortex;
• fever;
• Hartnup's disease;
• Huntington's chorea;
• inadequate nutrition, fasting (kwashiorkore);
• malabsorption syndrome in severe diseases of the gastrointestinal tract;
• hypovitaminosis;
• nephrotic syndrome;
• pappataci fever (mosquito, phlebotomy);
• rheumatoid arthritis.

• increased arginine, glutamine - arginase deficiency;
• increased arginine succinate, glutamine - arginosuccinase deficiency;
• increased citrulline, glutamine - citrullinemia;
• increased cystine, ornithine, lysine - cystinuria;
• increased valine, leucine, isoleucine - maple syrup disease (leucinosis);
• increased phenylalanine - phenylketonuria;
• increased tyrosine - tyrosinemia.

• increased glutamine - hyperammonemia;
• increased alanine - lactic acidosis (lactic acidosis);
• increased glycine - organic aciduria;
• increased tyrosine - transient tyrosinemia in newborns.

At the Doctor Nearby clinic, it makes it possible to determine the content of these beneficial compounds in the body. Today, more than a hundred amino acids are known, but only 32 of them provide protein production. Depending on the possibility of creation in the body, amino acids are divided into essential and non-essential.

Key essential amino compounds:

• Valin;
• Arginine;
• Methionine;
• Phenylalanine;
• Tryptophan;
• Lysine and others.

Key replaceable substances:

• Alanine;
• Acylcarnitine;
• Citrulline;
• Glycine;
• Glutamate;
• Asparagine and others.

These acids are needed for many metabolic processes in the human body. If the enzymes involved in the transformation are disrupted, the concentration of certain amino acids may increase. This negatively affects the functioning of various organs and systems. The pathology of amino acid metabolism can be hereditary or acquired.

Birth defects are inherited in an autosomal recessive manner and usually occur in early childhood. This group of diseases is caused by a lack of transport protein molecules and enzymes involved in the metabolism of amino acids. They can manifest themselves with various symptoms, ranging from minor malaise to severe general impairment, vomiting, coma, delayed physical and intellectual development, osteoporosis and osteomalacia.

In many diseases of internal organs, acquired or secondary metabolic disorders are observed.

Pathological conditions accompanied by impaired amino acid metabolism include diseases of the digestive system (,), urinary system (Fanconi syndrome), malignant neoplasms, and so on.

Prevention and effective treatment of these diseases makes it possible to slow down their progression and normalize metabolism.

To diagnose these pathological processes, doctors at the Doctor Nearby clinic prescribe a blood test for 32 indicators. This diagnostic procedure makes it possible to conduct a comprehensive assessment of the content of these substances and their derivatives in the blood, as well as determine the state of amino acid metabolism in the body. You can find out the price of a blood test for amino acids on the company’s official website.

Preparing for analysis

To obtain reliable research results, you must adhere to certain preparation rules. During the day before donating blood for analysis, you should stop drinking alcoholic beverages.

For 8 hours before taking biological material, the patient must refuse to eat. During this period, you are only allowed to drink purified water without gas.

In consultation with your doctor, you should stop taking medications the day before donating blood, if possible. For half an hour before the test, the patient is advised to refrain from smoking and try to avoid psycho-emotional and physical overload.

Indications for the study

Doctors at the Doctor Nearby clinic advise taking an amino acid test in the following situations:

• Suspicion of congenital and acquired disorders of amino acid metabolism;
• Differential diagnosis of the pathology of the metabolism of nitrogenous bases and their elimination (with an increase in the level of ammonia in the body);
• Monitoring the effectiveness of diet therapy and therapeutic measures;
• Comprehensive assessment of nutritional status and diet correction;
• Diagnosis of severe congenital disorders of amino acid metabolism in childhood in the presence of vomiting, metabolic acidosis, mental retardation and other characteristic signs;
• Screening in persons with a complicated medical history (congenital disorders of amino acid metabolism in relatives).
• Examination of people involved in professional sports (weightlifters, bodybuilders), especially those taking protein supplements.
• Assessment of amino acid metabolism in vegetarians.

How the research works

Interpretation of amino acid test results

Deciphering the analysis takes one business day. After this, the patient receives a conclusion about the results of the analysis, with which he goes to his doctor. When interpreting the results, the age of the patients, dietary habits, the presence of symptoms of any diseases and other laboratory data are taken into account.