Available and effective analogues of isoprinosine for papillomas. Isoprinosine for human papillomavirus Treatment of papillomas with isoprinosine

Isoprinosine for HPV is an effective non-targeted antiviral agent that fights various states of the human papillomavirus. The drug is available in tablet form and can be taken by children from 3 years of age. Experts and buyers leave mostly positive reviews about the action of the medication. The product helps prevent further development of papillomas and warts, the emergence of new foci of the disease, increases overall immunity and fights viral RNA replication.

Composition and principle of action

Isoprinosine for papillomas consists of inosine pranobex (active substance). This compound has a positive effect on the body's immune system and has a nonspecific antiviral effect. Isoprinosine affects viral RNA and stops the replication of viruses, as well as the spread of infected proteins. Due to this, the development of the virus stops, and it becomes easier for the body to overcome it.

Besides, These tablets for warts and papillomas increase the production of lymphocytes. They suppress the activity of viruses and produce natural interferon alpha - a powerful antiviral substance that helps not only with HPV, but also with hepatitis. However, given that the generation of interferon is limited by natural dosages, the substance only acts on weaker viruses.

Isoprinosine for condylomas (sexual type HPV) suppresses not only the activity of the virus itself, but also inflammatory processes in the pelvis, which often stimulate the development of the human papillomavirus. Due to this, immunity is restored and the number of complications is reduced; The body copes with the virus on its own.

Because HPV is an incurable viral disease, isoprinosine does not allow for full-fledged therapy. However, this drug stops the replication of the virus, which is enough to achieve a therapeutic effect. While taking the product:

• the appearance of new foci of condylomas stops;
• already formed warts die off (not always);
• The risk of developing cancer due to HPV is significantly reduced.

Due to the beneficial effect on the body’s immunity, even after discontinuation of the course, the therapeutic effect remains for some time.

Indications and contraindications

Isoprinosine is prescribed for HPV type 16, HPV types 56 and 18, as well as many other strains. It has a nonspecific antiviral effect, so it can help against all strains of the human papillomavirus. In case of infection with papillomavirus infection, the drug will best help against papillomas in the larynx and genital area.

Isoprinosine also acts against other viral diseases:

• herpes infections, including the Epstein-Bar virus, which causes proliferation of lymphoid tissues;
• molluscum contagiosum;
• influenza and ARVI;
• measles;
• herpes zoster;
• mononucleosis.

Will this remedy help fight AIDS in HIV? Unfortunately, isoprinosine has no effect against this virus.

The drug does not help with bacterial infections, such as chlamydia. It can only reduce the inflammatory process.

Contraindications to the use of isoprinosine are as follows:

• age up to 3 years (or weight up to 15 kg);
• gout;
• arrhythmic heartbeat disorders;
• stones in the urinary system;
• individual intolerance to the components of the composition.

If signs of allergy are detected, the drug should be stopped and the patient should consult a doctor.

How to use isoprinosine for HPV

How to take isoprinosine for condylomas and papillomas for adults and children? The instructions for use describe this process in detail.

Treatment with isoprinosine is carried out using tablets. They are convenient to take with you to work or on the road. The drug should be taken according to the prescribed dosage 3-4 times a day. The prescribed number of tablets, without chewing, is washed down with water. The patient can take the drug regardless of meals, on an empty stomach or after meals.

After a month of therapy, the patient must visit a doctor to monitor liver and kidney functions. It is recommended to see your doctor every two weeks to check the effectiveness of treatment and adjust the dosage based on individual indications.

Dosage calculation rules

For papillomas, the dosage is calculated based on the patient’s body weight. The dose for children over 3 years of age is 250 mg per 5 kg of weight. The dose obtained by calculation is divided into 3 or 4 doses. Children can be given no more than 50 mg per kilogram of weight per day.

In adults, the maximum dosage is 3 to 4 g. The exact dose should be calculated based on weight, as well as the testimony of a specialist. The standard dosage for a patient is 6 to 8 tablets with a dosage of 500 mg. The reception is divided into 3-4 parts. The dosage is calculated in the same way as for children: 250 mg per 5 kg of weight. If the patient's weight exceeds 80 kg, then the dose should be 4 grams per day.

Duration of therapy and number of courses

The course of treatment and dosage regimen depend on the type of HPV and the presence of complications. The treatment regimen for standard HPV, not complicated by additional diseases and not recurrent, is as follows:

• daily dose in adults – 3 tablets 2 times a day;
• children need to take 250 mg per 5 kg of weight in 3-4 doses;
• The duration of therapy ranges from 14 to 28 days, depending on the speed of manifestation of therapeutic effects.

How much to take the drug for recurrent condylomas? The same number of tablets should be used as for standard HPV. However, the course of therapy must be repeated: 3 courses of 14-28 days with an interval of 1 month. The drug can be used as the only treatment or as an additional procedure after destructive removal of formations.

For cervical dysplasia caused by papillomas, you need to take 2 tablets 3 times a day for 10 days. Then the course must be repeated twice, taking breaks of 10 days.

Side effects and combination with alcohol

Isopronisine should not be combined with alcoholic beverages. This may cause increased stress on the liver. As a result of the harmful effects of ethanol, coupled with the toxic substances of the drug, hepatocytes are destroyed. This can lead to the formation of connective tissue in place of functioning cells and, as a result, to liver fibrosis.

In addition, when a patient simultaneously consumes medication and alcoholic beverages, due to the increased load on the liver, it works more slowly and does not remove toxins in a timely manner. Because of this, toxic substances accumulate in the body. They have a negative effect on the kidneys and can affect the nervous system.

You should consult a specialist about combining antiviral medication with ethanol-based drugs.

Various side effects are possible (both due to alcohol intake and due to overdose or allergic reactions):

• nausea and vomiting;
• stomach ache;
• headache and dizziness;
• itchy skin;
• pain in the joints, especially in the presence of diseases of cartilage tissue;
• sleep disorders;
• diarrhea or constipation.

Constant side effects are grounds for stopping therapy and selecting analogues.

Analogs

Isoprinosine is an effective medicine for human papilloma, but the drug has many side effects, is expensive and takes a long course of therapy. What can replace this medication?

Analogs are cheaper, but do not always guarantee the absence of side effects. Take the medications provided only after consulting your doctor.

One of the main analogues is Cycloferon. It is a little more expensive (190 rubles versus 250 for 10 tablets). In this case, the total number of tablets for the entire course of therapy ranges from 20 to 40, which is significantly less than when using isoprinosine. The drug helps against herpes infections and influenza. The exact therapeutic effect against papillomas has not been established.

Indinol will also work. The drug costs 2,200 rubles for 60 tablets, and you need to take one tablet for 21 days. A large package is suitable for partners, since HPV treatment is recommended for both sexual partners at once due to the high risk of transmission during sexual intercourse. Indinol is not an immunomodulator; it only has an antiviral effect. Its use should be accompanied by the use of drugs to improve immunity.

Opinions of doctors and buyers

Antiviral treatment based on isoprinosine is widely used in medical practice. Infectious disease specialists and dermatologists note that the effects of the drug are mainly positive. It allows you to stop the spread of many viruses and relieves the patient of unpleasant symptoms.

Among the disadvantages noted by patients and doctors are side effects and expensive treatment. Due to the duration of use (treatment time ranges from 14 to 30 days), and 6 to 8 tablets must be taken daily, large amounts of money are spent on therapy.

Isoprinosine for HPV has been used in world medical practice since the early 70s of the twentieth century. The widespread use of the drug in the clinical treatment of viral infections is due to its effectiveness and safety.

Human papillomavirus is a widespread infection that leads to such serious diseases as neoplastic changes in the epithelium and cervical cancer. There are no methods or means to completely destroy the virus.

Pharmacological action of the drug

Now Isoprinosine exists in a single pharmacological form - tablets for oral use. In terms of its chemical composition, inosiplex is a derivative of purines found in many natural compounds. The therapeutic effect of Isoprinosine is based on inhibition of DNA and mRNA synthesis in the core of the virus. In addition, the drug has immunostimulating properties.

The drug stimulates the production of endogenous cytoleukins (IL-1 and IL-2) and γ - interferon. Group 1 cytoleukins have anti-inflammatory properties. Group 2 cytokines have a regulatory effect on the functions of lymphocytes, macrophages, T-helpers and activate cellular immunity, stimulate the processes of proliferation, differentiation and functions of specialized cells of the immune system. Thus, the drug provides:

• antiviral;
• anti-inflammatory;
• immunostimulating effect.

These properties determine the effectiveness of the drug Isoprinosine against acute forms of HPV caused by the complex action of external factors, a sexually transmitted infectious agent and decreased immunity.

Isoprinosine acts on both modified cells and the virus. By inhibiting cytoleukins of groups 4 and 10 and stimulating the production of IL-1, the drug affects intracellular processes, localizing and destroying the source of inflammation. Isoprinosine activates intracellular cytotoxic T lymphocytes. The drug stimulates the synthesis of T-helpers and T-suppressors, which ensure the identification and neutralization by other cells of viruses and damaged structures of their own tissues. In addition, the drug stimulates the synthesis of IgG antibodies, which cause an immune response.

In addition to systemic immunity, Isoprinosine activates local immunity, which fights viral infection directly at the site - on the surface of the epithelium or in its deep layers. The advantage of the medicine is that it acts in areas of papillomas and condylomas that are difficult to reach for surgical or laser treatment, in the nerve ganglia.

Thanks to the dual effects of Isoprinosine - antiviral and immunostimulating - it is effective against a large number of HPV strains, including highly oncogenic ones. Isoprinosine is well absorbed from the gastrointestinal tract. Its maximum concentration in the body is observed within 1.5-2 hours after admission.

The metabolism of the substance is characteristic of purines. The drug breaks down to uric acid and metabolites, which are excreted from the body in the urine. Complete elimination of the drug occurs within 1-2 days. Isoprinosine does not have cumulative properties.

Dosage and methods of therapy

The drug is successfully used in the treatment of papillomas of any location, genital warts and papillomatosis. The dosage of Isoprinosine is individual and depends on age, body weight and severity of the disease. The recommended dose of the drug for HPV is:

1. For adults and adolescents over 12 years old - take 3 times a day in the dosage prescribed by your doctor. The tablets are taken whole - without chewing or crushing in any other way. Drink plenty of plain water.
2. For children from 3 to 11 years old, the dose of the drug is calculated based on body weight. The received dose should be divided into 3-4 doses during the day.

As a result of clinical studies, doses and treatment regimens for various pathologies caused by HPV were established.

For example, for the treatment of cervical intraepithelial neoplasia (CIN), the drug was used in a dosage calculated per kilogram of body weight. The calculated amount of medication was divided into 3-4 doses per 24 hours. In the case of grade 1 cervical dysplasia, monotherapy lasted 10 days, and in the case of grade 2 CIN - 21 days.

As a result of treatment, in almost 90% of patients the disappearance of pathological changes in the epithelium of the external cervical canal was histologically confirmed. Relapse of the disease after six months was noted only in less than 3% of treated women. Moreover, a significant increase in the level of T-lymphocytes and the immunoregulatory index was noted.

Also, treatment of women with chronic cervicitis and stage 1 CIN using Isoprinosine at a dosage divided into 3 doses and a course of 10 days was accompanied by the complete absence of papillomavirus in histological samples in 67% of patients.

When treating genital papillomas, especially those aggravated by various urogenital infections, the duration of exposure increases by 3-4 times. The disease easily becomes chronic and tends to recur. For treatment, a combined destructive effect on tumors is used during the use of the drug.

The following course of therapy is proposed - during the period of exacerbation of the pathology, you need to take a large dose of Isoprinosine 3-4 times a day. The duration of the course is 5 days. Starting from the sixth day, maintenance therapy is carried out (smaller dose 2 times a day). The duration of therapy is up to six months. The course is repeated three times with an interval of 1 month. If the localization of papillomas is insignificant or isolated, and the formations themselves have a low degree of megalysis, then the drug is prescribed in a standard therapeutic dosage. The course of taking the drug is 2-4 weeks.

Other treatment regimens

The next treatment option: first, the infection is suppressed with the help of the drug, and then an operation is performed to remove the papillomas using one of the existing methods.

In the treatment of cervical cancer and CIN II-III degrees caused by highly oncogenic strains of HPV 18 and HPV 16, the therapeutic effect using this medication was carried out in a high dosage, divided into 3 doses per day.

The treatment lasted 10 days. At the end of the period, a histological examination was carried out after 10 days. In the majority of patients (88%), the effect was observed after one course of treatment, 19% required 2 courses of therapy, and only 2.5% needed 3 courses. Antiviral therapy using Isoprinosine is mandatory, since after removal of genital papillomas, viral activity is of great importance in the recurrence of the disease. Moreover, it was noted that the use of the drug made it possible to increase the effectiveness of therapy to 88% versus 66% when using only surgical removal of papillomas.

It was also noted that the effectiveness of therapy increases with a decrease in the degree of CIN. With the same treatment regimen, its effectiveness was respectively: CIN-I (93%), CIN-II (81%). When studying different age groups, it was noted that the effectiveness of the effect depends on the age of the patients and the duration of the disease. Most likely, this result is associated with the duration of persistence of the virus and, accordingly, with more massive damage to cervical tissue. For diagnosed cervical dysplasia caused by HPV 16, the following therapeutic regimens are used:

1. Take the medicine in a standard dosage for a course of 2 weeks.
2. Daily intramuscular injections of Glutoxim solution, in a standard dosage for an adult, for a course of 7-10 days. Then switch to a maintenance course every other day, when you need to take Glutoxim for another 10 days.

In addition, specialists can use this method:

1. Take the drug in 3 courses of 10 days, with intervals of the same duration between them.
2. Introduce Genferon vaginal suppositories daily.
3. Local treatment with Epigen Intim spray 3 times a day.

Side effects of the drug

Isoprinosine is well tolerated even with a long therapeutic course.

As a result of clinical studies of the drug, isolated cases of an allergic reaction were observed. Only one patient who took this medicine developed a rash after a second course. The allergy was relieved within 3 days. The patient was prescribed to take antihistamines.

In another group of patients undergoing therapy for a viral infection of the vagina, 2 cases of allergies were noted, which resolved on their own. It was noted that the drug was associated with symptoms of mild deterioration and nausea in the age group of one woman who was taking the drug for cervical cancer. In other cases, the medicine did not produce side effects.

Contraindications to the use of the drug

• deposition of urates in tissues and joints;
• formation of stones in the kidneys and bladder;
• heart rhythm disturbances;
• proneness to allergies;
• pregnancy and breastfeeding.

People with pathological excretion of uric acid are recommended to take the drug under the control of urate levels in the body. With long-term use of Isoprinosine, you need to monitor the composition of peripheral blood, uric acid and creatine levels monthly.

In general, drug therapy for papillomas is effective and efficient, and usually occurs without side effects.

The human papillomavirus must be treated with medications that act on the structures of the causative agent of the disease and do not allow it to spread throughout the body. Isoprinosine copes well with this task.

It can be purchased at any pharmacy after providing the pharmacist with a prescription from a doctor. This means that the medicine must be prescribed by a specialist, since with self-medication the patient risks worsening the condition.

1 tablet contains 500 mg of the main component inosine pranobex. It is used to suppress the activity of papillomavirus. Thanks to it, the drug copes with such diseases and restores the functioning of lymphocytes even despite reduced immunity.

This is one of the currently relevant antiviral drugs with a wide range of actions. Its main “trump card” over other similar drugs is that the tangible strength of its effect on the human papillomavirus and other viruses has been confirmed in clinical trials and placebo-detecting studies.

The drug was first synthesized in the seventies of the last century in the USA as an antiviral agent. Then its immunomodulatory property was discovered.

The medicine is popular because of its safety and effectiveness. It is successfully used both for the treatment and prevention of HPV and other viral diseases (more than 20 items).

Diseases caused by the human papillomavirus can now be effectively treated. Success in this case is achieved through the use of drugs that suppress the reproduction of viral DNA and RNA, as well as stimulate the immune system in general.

These properties are fully present in Isoprinosine, which can be purchased with a doctor's prescription.

One tablet of the drug contains 500 mg of the active substance - inosine pranobex, which successfully fights this type of virus. Isoprinosine allows you to quickly restore the functions of lymphocytes even with reduced immunity and exhibits high activity against various types of viruses.

These are cytomegalovirus, influenza virus, measles, encephalomyocarditis and others. The drug suppresses the synthesis of RNA and viral proteins, and also increases the production of interferons.

Thanks to the use of this drug, the body produces special antibodies that successfully fight viruses. The advantage of Inoprinosine is that it is well studied, so doctors know how it affects any infections.

Clinical trials of this drug were carried out in 2008. According to their results, relapses of the disease in patients decreased by 3 times over six months of using the drug.

This remedy also showed a good effect on small papillomas and in the absence of obvious symptoms of HPV. As a result of using the drug, every second woman experienced the disappearance of condyloma, so its surgical removal was not required.

The drug Isoprinosine is available in the form of tablets, the number of which in a package can reach 50 pieces. The drug is well absorbed and enters the bloodstream within 2 hours after administration.

It can be used in combination with other antiviral drugs, for example, interferon. In this case, the medicine does not accumulate in the body and is excreted naturally in the urine in just 2 days.

Isoprinosine has an excellent therapeutic effect against the human papillomavirus, which can be obtained through any contact with a patient. Before starting treatment with this drug, you need to know the strain of the virus, the general state of the immune system, as well as the characteristics of this infection.

With the help of Isoprinosine, you can significantly reduce the clinical manifestations of HPV, as well as quickly remove any papillomas and condylomas.

In addition, this drug is prescribed for viral respiratory diseases, for example, tonsillitis, ARVI, rhinitis, when the immune system cannot cope with the disease.

This is especially true for children who are often ill. Isoprinosine is also used to treat chickenpox, resulting in a mild form of the disease, with virtually no fever or skin rashes.

In addition, the child recovers very quickly.

Isoprinosine - instructions for use, reviews, analogs and release forms (500 mg tablets) of the drug for the treatment of influenza, herpes, HPV (human papillomavirus) in adults, children and pregnancy

In this article you can read the instructions for use of the drug Isoprinosine. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Isoprinosine in their practice are presented.

We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation.

Isoprinosine analogues in the presence of existing structural analogues. Use for the treatment of influenza, herpes, HPV (human papillomavirus), as well as other colds in adults, children, as well as during pregnancy and lactation.

Isoprinosine is an immunostimulating drug with an antiviral effect. Isoprinosine is a synthetic complex purine derivative with immunostimulating activity and nonspecific antiviral effect.

Restores the functions of lymphocytes in conditions of immunosuppression, prevents a decrease in the activity of lymphocyte cells under the influence of glucocorticosteroids, and normalizes the inclusion of thymidine in them. Isoprinosine has a stimulating effect on the activity of cytotoxic T-lymphocytes and natural killer cells, the functions of T-suppressors and T-helpers, increases the production of IgG, interferon gamma, interleukins (IL)-1 and IL-2, reduces the formation of pro-inflammatory cytokines - IL-4 and IL-10 potentiates the chemotaxis of neutrophils, monocytes and macrophages.

The drug exhibits antiviral activity in vivo against Herpes simplex viruses (herpes simplex virus), cytomegalovirus and measles virus, human T-cell lymphoma virus type 3, polioviruses, influenza A and B, ECHO virus (human enterocytopathogenic virus), encephalomyocarditis and equine encephalitis.

When administered in combination, it enhances the effect of interferon-alpha, the antiviral agents acyclovir and zidovudine.

Pharmacokinetics

After oral administration, it is well absorbed from the gastrointestinal tract. Inosine is rapidly metabolized through a cycle typical of purine nucleotides to form uric acid. It is excreted in the urine unchanged and in the form of metabolites within 48 hours. No accumulation is observed.

• treatment of influenza and other acute respiratory viral infections;
• infections caused by the Herpes simplex virus types 1, 2, 3 and 4: genital and labial herpes, herpetic keratitis;
• herpes zoster, chicken pox;
• infectious mononucleosis caused by the Epstein-Barr virus;
• cytomegalovirus infection;
• severe measles;
• papillomavirus infection: papillomas of the larynx/vocal cords (fibrous type), papillomavirus infection of the genitals in men and women, warts;
• molluscum contagiosum.

Release forms

Tablets 500 mg.

Instructions for use and dosage

The tablets are taken after meals with a small amount of water.

The recommended daily dose for adults and children aged 3 years and older (with a body weight of 15-20 kg) is 50 mg/kg body weight in 3-4 doses, which is an average for adults - 6-8 tablets per day, for children - 1/2 tablet per 5 kg of body weight per day.

In severe forms of infectious diseases, the dose can be increased individually to 100 mg/kg body weight per day, divided into 4-6 doses. The maximum daily dose for adults is 3-4 g per day, for children aged 3 years and older - 50 mg/kg per day.

The duration of treatment for acute illnesses in adults and children aged 3 years and older usually ranges from 5 to 14 days. Treatment should be continued until clinical symptoms disappear and for another 2 days in the absence of symptoms. If necessary, the duration of treatment can be increased individually under the supervision of a physician.

For chronic recurrent diseases in adults and children aged 3 years and older, treatment should be continued in several courses of 5-10 days with a break of 8 days.

For maintenance therapy, the dose can be reduced to 500-1000 mg per day (1-2 tablets) for 30 days.

For herpes infection in adults and children aged 3 years and older, the drug is prescribed for 5-10 days until the symptoms of the disease disappear; during the asymptomatic period - 1 tablet 2 times a day for 30 days to reduce the number of relapses.

For human papillomavirus infection, adults are prescribed the drug 2 tablets 3 times a day, children aged 3 years and older - 1/2 tablet per 5 kg/body weight per day in 3-4 doses for 14-28 days as monotherapy.

For recurrent genital warts, adults are prescribed the drug 2 tablets 3 times a day, children aged 3 years and older - 1/2 tablet per 5 kg/body weight per day in 3-4 doses, either as monotherapy or in combination with surgical treatment for 14-28 days, then repeating the specified course three times at intervals of 1 month.

Side effect

• nausea, vomiting;
• epigastric pain;
• skin itching;
• headache, dizziness, weakness;
• drowsiness, insomnia;
• polyuria;
• joint pain;
• exacerbation of gout.

Contraindications

• urolithiasis disease;
• gout;
• arrhythmias;
• chronic renal failure;
• children under 3 years of age (body weight up to 15 kg);
• hypersensitivity to the components of the drug.

Use during pregnancy and breastfeeding

The safety of using Isoprinosine during pregnancy and lactation has not been established, therefore the use of the drug is not recommended.

special instructions

After 2 weeks of using Isoprinosine, it is recommended to monitor the level of uric acid in the blood serum and urine. After 4 weeks of use, it is advisable to monitor liver and kidney function every month (transaminase activity, creatinine, uric acid levels).

It is necessary to monitor the level of uric acid in the blood serum when prescribing Isoprinosine in combination with drugs that increase uric acid levels or drugs that impair renal function.

Impact on the ability to drive vehicles and operate machinery

There are no special contraindications for driving vehicles or operating machines and mechanisms.

Drug interactions

When used concomitantly, immunosuppressants may reduce the effectiveness of Isoprinosine.

Xanthine oxidase inhibitors and uricosurics (including diuretics) may contribute to the risk of increased serum uric acid levels in patients taking Isoprinosine.

Analogues of the drug Isoprinosine

Women's health: how to avoid trouble if you are infected with HPV type 68

The human papillomavirus enters the human body through direct touch to the carrier of the virus. In addition, contact with damaged skin can also cause infection. In other words, infection occurs not only, for example, during sexual contact or when visiting public places, but also with an ordinary handshake.

Before starting treatment, it is necessary to make a correct diagnosis. To do this, the doctor conducts an initial examination, studies the patient’s complaints, and examines the affected areas.

In men, HPV is determined using specialized studies that have varying degrees of complexity:

• DNA diagnostics;
• Study of tissues affected by the disease. Tissues are collected using a biopsy;
• Study and examination of smears taken from the urethra;
• Other special tests.

It is important to undergo a thorough medical examination, since some of these viruses have oncogenic activity. Do not neglect repeated or additional examinations, because a correctly made diagnosis is already half the positive result.

There is an incredible number of different viruses in the world, and among them there are some that we may not be aware of in our body for a long time. One of these viruses is the human papilloma virus in men - a disease that can “live” in the human body for a huge period of time without any external manifestations.

From the moment of infection to the appearance of papillomas on the body, it can take from several months to several years. A special risk group consists of men who lead an unhealthy lifestyle, abuse alcohol, are employed in heavy industries, or have suffered from various diseases, as a result of which their immune system is extremely weakened.

When external signs of the disease appear - the appearance of various neoplasms on the surface of the body, including genital warts, it is important to begin treatment as quickly as possible in order to avoid further damage to the body.

The sooner you learn how to treat HPV in men, the more help you will provide to your health, and the easier the treatment process itself will be.

How to cure HPV

Treatment of HPV in men should be carried out under the supervision of a physician. It is highly undesirable to get rid of papillomas on your own. It should be noted that the treatment process is quite complex and almost always requires the assistance of a number of medical specialists in related fields: dermatologists, urologists and immunologists.

Modern medicine offers several methods aimed at getting rid of HPV, but none of them guarantees a complete cure.

The virus has the ability to persist in the tissues of the body and, at the slightest weakening of the immune system, becomes active again. Today there are no drugs that would guarantee complete relief from the disease. However, measures taken to combat the virus should be aimed at strengthening the body's immune forces. During the treatment of HPV, the following methods are used:

• Surgical intervention;
• Conservative method;
• Traditional methods of fighting the virus.

The surgical method involves excision, which requires anesthesia. It is performed with a laser, liquid nitrogen or using electrocoagulation. At the same time, it is necessary to carry out strengthening, antiviral and immunostimulating therapy in parallel.

The conservative method involves treatment using such agents as immunomodulators for HPV, vitamin therapy and antiviral drugs for HPV. Today on the pharmaceutical market you can find a huge number of drugs that help fight the virus and strengthen the immune system. Particularly popular are the following HPV pills:

• Panavir. Russian drug of plant origin, intended to combat a wide range of viral diseases;
• Groprinosin. An immunostimulating agent with a pronounced antiviral effect;
• Cycloferon. It has a direct antiviral effect, suppressing the development of the virus in the early stages. Cycloferon for HPV is used quite often today;
• Isoprinosine. It has immunostimulating activity and nonspecific antiviral effect. It is one of the most commonly used drugs in the treatment of HPV. This drug can act directly on the pathogen, thereby inhibiting its development;
• Viferon. Promotes an increase in the specific antiviral activity of human interferon;
• Allokin alpha. Low-toxic, non-allergenic antiviral drug;
• Indinol. Indinol, for which there are a wide variety of reviews today, is used in the complex treatment of diseases associated with the human papillomavirus;
• Ferrovir. Ferrovir reviews for which today also do not have one direction, are aimed at activating antiviral and antifungal immunity.

The last two drugs listed above are not medicines, but dietary supplements, which also have an immunomodulatory effect on the body. The wide spectrum of action of the drugs is explained by their use not as individual drugs, but in complex therapy with other immunostimulating or antiviral drugs.

These drugs should be used extremely carefully and only on the recommendation of a doctor, since, for example, indinol, for which there are a wide variety of reviews today, has a number of significant contraindications and does not have an independent wide spectrum of effects, like some other drugs.

In addition to the above agents, there are their direct analogues, which have no less antiviral and immunostimulating properties.

It should be noted that none of these drugs should be used without appropriate prescription, since they affect not only the virus, but the entire body. Also, some of the medications are quite complex and can cause side effects.

So, according to the opinion of many experts, for example, the drug indinol has not only positive reviews. Moreover, it is designed more for the female half of the population than for men.

Local therapy for HPV also involves the use of antiviral ointments and gels. Among them are salicylic acid, oxolinic ointment, lapis, CryoPharma ointment, celandine extract and others. But again, they can only be used in combination and only as prescribed by a doctor, since each of the listed drugs has a wide range of contraindications for use.

Among the folk methods of combating HPV, iodine, potatoes, apples, onions, rowan berries and various fruit and berry mixtures are used. Such means of control can be used after consultation with a doctor and only as an addition to the main treatment.

Treatment of the disease should be exclusively comprehensive and individually selected. One patient may only need drug treatment, while another may not need surgery.

Which group each patient belongs to will only be determined by a specialist.

HPV 68 (human papillomavirus, or HPV) is a type of sexually transmitted disease that often occurs in patients of all ages, regardless of gender. The danger of this group of viruses lies in their ability to lead to cancer, primarily in the body of women.

To date, about 120 varieties of HPV have been identified. Each HPV genotype poses a specific health threat, but not all of them are capable of developing into cancer cells.

The group of the most dangerous includes 68, 51-59, 31-39, 18 and 16 types of viruses. The introduction of this type of virus into the DNA of cells, as a rule, in 70% of cases results in cervical cancer and requires mandatory observation by an oncologist.

Transmission routes

How to take Isoprinosine when treating HPV

Despite the numerous advantages of Isoprinosine, there are contraindications to the use of the drug. In particular, it is not recommended for people who have gout, urolithiasis, kidney failure, heart rhythm disturbances, a child under 3 years of age, or low body weight not exceeding 10 kg.

During pregnancy, the drug is rarely prescribed, since no special studies have been conducted on the effect of the drug on fetal development and the course of pregnancy.

If the situation is not critical, it is better to start treating the infection after delivery. It is even better to do this while planning a pregnancy, which will protect the child from infection and prevent possible complications of pregnancy.

It is better to take Isoprinosine after meals, and not on an empty stomach, to avoid discomfort from the gastrointestinal tract. In addition, it is possible to develop such side effects as:

• nausea;
• bloating;
• diarrhea;
• pain in the head area;
• allergic reaction in the form of itching of the skin;
• joint inflammation.

If side effects occur, you should stop taking the drug and consult a doctor for possible prescription of more gentle analogues.

At the time of therapy with an immunostimulating agent, it is necessary to completely stop drinking alcohol, even in small quantities. Alcohol creates a greater load on the liver and organs of the urinary system, which can lead to increased side effects.

A wart can be easily confused with manifestations of other more serious diseases - skin cancer, seborrheic ketarosis, molluscum contagiosum. Therefore, any appearance of growths on the skin requires consultation with a surgeon or dermatologist. Especially if you have symptoms such as:

• changes in the color and shape of the growth, as well as the clarity of its outlines;
• permanent injury;
• pain and ulceration of the surface of the tumor;
• rapid growth of growths;
• the appearance of formations on the skin and mucous membranes of the genital organs.

Depending on the type of wart and its location, the doctor decides on treatment. If the growth does not interfere, does not spoil the quality of life and is of a type that goes away on its own, then it cannot be treated.

There are 2 ways to treat warts - medicinal and radical elimination. One of the drugs that is used in the treatment of warts is Isoprinosine.

Human papillomavirus infection (PVI) is considered the main etiological factor not only of papillomas, but also of cervical intraepithelial neoplasia (CIN) and cervical cancer (CC). This infection is often combined with other infections - bacterial vaginosis, herpes virus, chlamydia, candidiasis, gonorrhea 1, which makes its diagnosis difficult.

There are no methods of therapy to achieve eradication of the human papillomavirus (HPV), and therefore treatment consists of local (destructive; physiosurgical) and systemic (immunostimulating and antiviral) components2.

At the same time, the cost of destructive treatment is high, and it does not guarantee complete disappearance of the virus from locally distant areas of the altered epithelium; in addition, PVI resolves spontaneously in many cases, so many foreign experts recommend monitoring this infection with regular cytological monitoring.

The early stages of CIN are often accompanied by infection with the usual opportunistic flora (staphylococcal, streptococcal, etc.), chronic cervicitis and vaginitis, and leucorrhoea (Prilepskaya V.N.).

It is possible to treat such patients without resorting to destructive methods, but to achieve a sustainable effect it is necessary to carry out both antiviral and immunomodulatory treatment. One of the drugs that provides this effect is Isoprinosine.

Isoprinosine has been used in world medical practice since the beginning of 1970. It is registered in 73 countries. Chemically, Isoprinosine is a purine derivative and is therefore metabolized in a cycle typical of purine nucleotides to form uric acid and is excreted by the kidneys within 48 hours.

Thanks to this, Isoprinosine is well absorbed in the gastrointestinal tract; however, it is not recommended to use it in case of renal failure, gout, or urolithiasis.

The pharmacological effect of Isoprinosine is associated with the suppression of the synthesis of DNA and mRNA of viruses in the ribosome of cells, the activation of T-lymphocytes (and it even blocks the suppressive effect of glucocorticoids on them), and the stimulation of phagocytic cells (due to the activation of biochemical processes in them). In addition to cellular immunity, the drug activates the synthesis of antiviral proteins - interferons.

These properties allow it to act especially effectively in manifest forms of HPV infection, usually caused by the combined effect of social factors, infections (sexually transmitted diseases), and changes in immune status.

In a randomized, double-blind, placebo-controlled trial, Isoprinosine was effective in subclinical vulvar HPV3 lesions. The study involved 55 women, divided into 2 groups, receiving either Isoprinosine (1000 mg 3 times a day) or placebo for 6 weeks.

In the treatment group, a statistically significant decrease in vulvar itching was noted, and it was also combined with a morphological improvement in the condition of the vulvar epithelium (p = 0.005). These positive changes were maintained 4 months after the start of treatment.

Monotherapy with Isoprinosine is also effective for CIN. The effectiveness of Isoprinosine treatment can be assessed using cytological monitoring, naked eye examination and colposcopy.

A comparative study of various outpatient methods for diagnosing cervical HPV lesions involving 640 women4 showed that colposcopic examination is optimal for screening purposes.

In a clinical study with monotherapy with Isoprinosine 50 mg/kg 3-4 times a day in 44 women suffering from CIN I (28 women; therapy for 10 days) and CIN II (16 women; for 21 days), it was found that a pronounced a clinical effect was observed in 88.6% of patients - damage to the exocervix epithelium completely disappeared, which was confirmed colposcopically and histologically5.

Relapse occurred after 6 months in only 2.6% of cases with effective treatment. It should be noted that simultaneously with the virological effect, an immunological effect was also achieved: the number of T-lymphocytes and the immunoregulatory index CD4/CD8 increased.

In a similar study involving 29 women with CIN I against the background of chronic cervicitis, a combination of etiotropic therapy with taking Isoprinosine 1000 mg 3 times a day for 10 days provided a clinical effect (disappearance of leucorrhoea) in 72% of cases and HPV eradication during a 3-month follow-up in 66% of cases (Prilepskaya V.

It is known that under the influence of concomitant infections (urogenital chlamydia, mycoplasmosis, cytomegalovirus and herpetic infections, dysbiotic conditions), the treatment period for HPV infection is extended by an average of 3 times, relapses of the infection often develop, and it becomes more easily chronic6.

In this regard, such combined lesions are usually treated locally (medically and surgically; the effectiveness of local treatment reaches only 85-90%). The most promising method seems to be a combined method - removal of condylomas against the background of systemic antiviral treatment7.

Its effectiveness reaches 100%, which is associated with the effect of the drug on HPV not only in areas where condylomas are localized that are difficult to reach for surgical or laser treatment, but also in the nerve ganglia8.

In the acute phase, Isoprinosine is prescribed at 50 mg/kg of the patient’s body weight (6-8 tablets/day, divided into 3-4 doses) for 5 days.

When the relapse subsides (starting from the 6th day), a maintenance dose is prescribed: 1 tablet 2 times a day for up to 6 months9. A regimen with three repetitions of the course of therapy with an interval of 1 month has also been proposed. In the treatment of small, multiple genital warts with a low degree of malignancy, it is proposed to prescribe the drug 2 tablets 3 times a day for 14-28 days (Bogatyrev I.I.).

One option for combination therapy is to first suppress the HPV infection with medication, then carry out destructive treatment. In a prospective study using Isoprinosine in 54 patients with CIN I-III degrees, as well as cervical cancer in situ, HPV infection of types 16 and/or 18 (associated with the risk of developing cervical cancer) was detected in 83% of patients, and they received courses of therapy Isoprinosine 1000 mg 3 times a day for 10 days with a control examination after another 10 days10.

In 87% of cases, one course of treatment was sufficient, in 20% of cases 2 courses were required, and only in 2% of cases - 3 courses. The authors concluded that in case of CIN, antiviral therapy must be carried out in the postoperative management of patients, since the activity of the virus is of key importance for the recurrence of the disease.

In another study, therapy with Isoprinosine (1000 mg 3 times a day for 5 days) 7-10 days before cryodestruction of CIN I lesions increased the effectiveness of treatment to 88% (compared to 66% with only local cryodestruction) (Prilepskaya V .

N.). At the same time, HPV activity was not detected in 66 and 47% of cases, respectively, and relapses of infection developed in 9 and 28% of cases, respectively.

Clinically, when cleared of HPV, epithelization of the cervix also improved. In another study, the recurrence rate of HPV lesions of the cervix after combination therapy in 62 women with CIN II-III was 1.6% (Zabelev A.

In general, the effectiveness of Isoprinosine therapy is higher with a lower degree of CIN: in one study for CIN I it was 93%, for CIN II - 81% (Potapov V.A.), and in another study for CIN I-II - 15 out of 20 ( 75%) of patients after the first course of therapy (Kedrova A.

G.). It is also important to note that the grade of CIN is usually proportional to the duration of the disease and the age of the patients (for example, in an outpatient study of 640 patients, the average age for CIN II was 35 years, and for CIN III it was 46 years).

This is probably due to longer persistence of HPV, which causes more pronounced lesions of the epithelium of the cervical mucosa (Potapov V.A.).

It should be noted that Isoprinosine therapy is well tolerated. Thus, in a study of 54 patients with CIN and cervical cancer, a total of 58 courses of treatment with Isoprinosine were carried out and an allergic reaction (rash) developed only in one case - during the second course of therapy. The reaction was stopped within 3 days by using antihistamines (Kedrova A.G.).

Four cases of mild malaise and nausea were also found to be possibly related to the drug. In a study of 29 women with CIN I, no side effects were identified when taking Isoprinosine (Prilepskaya V.

N.). In a study of 55 women who received the drug for HPV infection of the vulva, skin rashes were noted in 2 cases, mild and resolved without treatment (Tau S.

K.). This may be partly due to the fact that the drug is a derivative of a natural substance - purine.

Thanks to its dual - antiviral and immunomodulatory - action, Isoprinosine suppresses the replication of various types of HPV, including

and highly oncogenic, which ensures its effectiveness in any clinical and subclinical form of PVI (genital warts and CIN). In case of CIN, the drug appears to be effective and safe both in the early stages, incl.

hours as monotherapy, and later - as part of a combination of medicinal and destructive therapy.

Human papillomavirus (HPV) is a disease that causes the growth of warts and papillomas. However, this infection causes more than just cosmetic discomfort.

The virus has more than 100 subspecies, each of which contributes to the appearance of growths on the body and mucous membranes. And many of these pathological formations are prone to degeneration into cancer cells.

The disease is not cured completely, but when the body’s immune defense is strengthened, it can become inactive. Therefore, during treatment, it is important to use immunomodulators.

The most effective of them is Isoprinosine.

The principle of action of the drug

The drug Isoprinosine is a medicine in tablet form. The main active ingredient in it is inosine pranobex at a concentration of 500 mg.

This synthetic compound in its structure resembles the constituent molecules of DNA, and is an analogue of nitrogenous purine bases. Due to this similarity, when the drug enters the bloodstream, it begins to stimulate the immune system, becoming a kind of nucleic acid that nourishes it.

The main positive effects of Isoprinosine on the protective functions of the human body are as follows:

1. Stimulation of the activity of lymphocytes that provide protection against infections;
2. An increase in the number of highly specialized cells of the human immune system, T-helpers. They are responsible for eliminating body cells already infected with viruses or infection;
3. Stimulation of interferon, a substance responsible for searching and recognizing cells potentially dangerous to the body. When a suspicious element is detected, interferon marks potentially dangerous cells and inhibits their activity until the arrival of T helper cells;
4. The amount of immunoglobulins increases, and there is also an increase in neutrophils and macrophages.

The main feature that Isoprinosine has for HPV is the ability not only to activate a person’s own immune defense, but also to successfully block the activity of the disease itself.

The drug is effective against many infectious diseases, but it is not suitable as a prophylactic agent.

Features of application

Since an overdose of the drug can lead to the development of negative reactions, when treating HPV with Isoprinosine, it is important to strictly adhere to the permissible dosage. The treatment regimen is prescribed exclusively by the supervising physician, and the drug itself is sold in pharmacies with a prescription.

1. 2 tablets 3-4 times a day for adult patients. The duration of treatment is 2-4 weeks. After this time, a break in taking the drug is taken for 1 month. If necessary, the therapeutic course is repeated;
2. For children over 3 years old and weighing more than 15 kg, the dosage of the drug is calculated using the formula 0.5 tablets per day for every 5 kg of body weight. The maximum daily dosage for a child is 2500 mg of the substance, which corresponds to 5 tablets. The dose corresponding to the child’s weight is taken 4 times. The course of treatment depends on the size and number of formations and can last 2-4 weeks.

This drug regimen is only relevant for the treatment of HPV. To eliminate other infectious or viral diseases, the dosage and frequency of administration vary.

In most cases, the patient’s body’s reaction to inosine pranobex is positive and the treatment does not cause side effects. However, there are some contraindications to the use of the drug. Isoprinosine should not be taken in the following cases:

• gout;
• urolithiasis, as well as a state of increased levels of uric acid in the body;
• renal failure;
• arrhythmia.

Also, the use of the drug is unacceptable in case of impaired metabolism of inosine pranobex, and hypersensitivity to any auxiliary components of the drug.

Since regular use of the drug places increased stress on the liver and kidneys, using the drug simultaneously with alcohol is unacceptable.

A huge number of strains of the human papillomavirus (HPV) cause a wide variety of tumors on the skin, larynx, genitals and other parts of the body. This virus invades cells and causes them to actively divide, which, in turn, accelerates the emergence of new viral particles, and some forms of HPV can even cause malignant cell growth.

There are several drugs to treat this condition, one of which is Isoprinosine, the advantage of which is that it can be used in both adults and children.

Description of the drug

The active ingredient of the drug is inosine pranobex - a compound similar in structure to the “building blocks” of the DNA molecule, which exists in all living things on Earth, including humans. It is an analogue of the so-called purine nitrogenous bases, due to which it stimulates the formation of new DNA and RNA molecules in human cells.

This is especially important for cells of the immune system, since they are the most actively dividing, consuming huge amounts of nucleic acids (of which DNA and RNA are varieties). Each Isoprinosine tablet contains 500 mg of active ingredient.

But what effects does activation of nucleic acid formation have on humans and how does this help in the fight against HPV? According to experts, when taking Isoprinosine the following changes occur in the body:

1. Restoring the activity of lymphocytes - the central cells of the human immune system. It is because of their “inaction” that it becomes possible for a person to be infected with HPV with the subsequent development of neoplasms. Indeed, according to medical statistics, two thirds of the world's population are carriers of this virus, but it manifests itself much less frequently precisely because of the low activity of lymphocytes.
2. Strengthens the work of natural killer cells and T-helpers - more highly specialized immune cells. They are responsible for destroying human cells already infected with the virus.
3. Stimulates the release of interferon, a biologically active substance that identifies infected cells, inhibits the development of the virus in them and serves as a “beacon” to attract natural killer cells.
4. In addition to interferon, the release of other active compounds of the immune system - interleukins, immunoglobulins and others - also increases.
5. Activation of other immune cells - neutrophils, macrophages.

All these effects significantly increase the body's resistance to any infections, especially viral ones. But besides this, Isoprinosine can also act directly on viruses - it, like interferon, inhibits the reproduction of the virus (blocks the synthesis of viral RNA) inside the cell.

This reduces the rate of spread of infection throughout the body and gives the necessary time to the immune system (also stimulated by the drug) to assemble and destroy the virus.

However, all the described effects are nonspecific, that is, they act not only in case of human infection with HPV, but also with a number of other viruses that cause herpes, chicken pox and shingles, mononucleosis, measles and influenza.

Therefore, doctors recommend taking Isoprinosine in case of such infections. This drug is not prescribed only for prevention - clinical studies have proven that in the absence of infection, all the effects of the drug are less pronounced, so there is no point in taking it.

How to take the drug

If you have papillomas and other symptoms of HPV infection, Isoprinosine can be taken from the age of three years. But it is important to observe the correct dosage of the drug, because if the dose is exceeded, various side effects and complications can develop. On the shelves of pharmacies you can find this remedy in the form of tablets containing 500 mg of active substance each.

The treatment regimen for HPV infection does not depend on the specific form of this disease. It can be used with equal effectiveness both for simple warts on the hands or body, and in the case of genital warts, papillomas in the larynx, multiple papillomas and other forms.

Many experts advise taking Isoprinosine in combination with other treatment methods - removal of tumors, external antiviral or cauterizing agents, and so on. This increases the effectiveness of treatment many times over and virtually eliminates possible relapses in the future.

1. For the treatment of diseases caused by HPV in adults, the recommended regimen is 2 tablets 3-4 times a day, that is, 6-8 tablets must be taken per day. The duration of treatment should be at least two weeks, usually the course lasts 14-28 days, after which a break of at least a month must be taken. If necessary and under the supervision of a doctor, the course can be repeated.
2. In children, the use of Isoprinosine is possible when they are at least 3 years old and weigh at least 15 kilograms. The dosage is calculated based on the fact that 5 kilograms of the child’s body weight should account for half a tablet of the drug per day. Thus, with a baby weighing 15 kg, take half a tablet 3 times a day, 20 kg - half a tablet 4 times a day, and so on. The course is otherwise no different from the treatment of diseases caused by HPV in adults - 2-4 weeks of admission and a month break.

In the case of other viral diseases, the dosage regimen may change, so when purchasing a drug you need to carefully study the leaflet - it describes recommendations for the treatment of each pathology. It is important not to confuse the description of eliminating HPV with treating, for example, measles.

Contraindications and side effects

Isoprinosine is very well tolerated by most patients, but some contraindications to its use exist. Basically, they are associated with the metabolism of inosine pranobex in the human body - it is processed in the liver and kidneys with the formation of sparingly soluble uric acid, which can create problems when using the drug.

The main contraindications to taking Isoprinosine are the following conditions:

1. Gout is a metabolic disease in which uric acid is deposited in the kidneys, joints and other tissues. Naturally, its increased formation as a result of taking this drug will not improve the course of this pathology.
2. Urolithiasis, or more precisely, some of its forms, which are accompanied by the formation of urate (that is, from uric acid salts) stones. Just as in the previous case, the formation of additional amounts of uric acid can worsen a person’s condition.
3. Chronic renal failure - almost all uric acid, which is formed during the metabolism of Isoprinosine components, is excreted through the kidneys. If their work is hampered, then conditions are created for the accumulation of this substance in the body in the form of kidney stones and crystals in tissues.
4. Arrhythmias - it has been found that this drug in some cases can disrupt the rhythm of heart contractions.
5. Intolerance to the components of the drug - allergic reactions in the form of rash and skin itching are a reason to discontinue this drug.

Human papillomavirus infection is one of the most common worldwide. Depending on the specific strain that affects a person, symptoms may be limited to the appearance of benign growths, or may gradually degenerate into cancerous tissue.

It is precisely because of the possible development of oncological processes that it is necessary to treat papillomavirus. Therapy includes various factors, one of which is the need to take medications. For example, Isoprinosine is used in the treatment of HPV. This is not a cheap product; its minimum price is 500 rubles.

The active component of Isoprinosine is a substance called pranobex. It is an analogue of purine nitrogenous bases, which is similar in structure to the components of DNA. Thanks to pranobex, the synthesis of human DNA and RKN is stimulated. This process is very important for the state of the immune system, and it, in turn, is important in HPV therapy.

Despite the widespread prevalence of the human papillomavirus, not everyone experiences symptoms of the disease. This is precisely related to the state of the immune system. If the body's defenses are in good condition, they will successfully suppress the activity of the pathogen. Otherwise, the virus will spread throughout the tissues, which will lead to the formation of condylomas.

The immunomodulatory effect of Isoprinosine is also achieved through increased interferon synthesis. This substance inhibits the activity of various microorganisms, such as bacteria and viruses. The medicine helps restore the activity of lymphocytes, the inactivity of which allows HPV to spread throughout the body.

The therapeutic effect is associated with increased work of a number of highly specialized immune cells that destroy tissues already infected with the virus. The tablets affect neutrophils, macrophages, interleukins, immunoglobulins and a number of other substances that are critical for immunity.

Indications for use

Although Isoprinosine can be used to treat manifestations of the human papillomavirus, the indications for the use of the drug are not limited to this disease. For example, tablets may be prescribed to combat:

• Flu and colds;
• Pathologies developing due to the Epstein-Barr virus;
• We deprive;
• Measles;
• Herpetic keratitis;
• Genital and labial herpes;
• Chicken pox;
• Molluscum contaginosa.

The possibility of use against a variety of diseases is due to the fact that Isoprinosine has a nonspecific effect. It inhibits the spread of various viruses inside cells, simultaneously helping the immune system cope with the pathogen on its own. The antiviral effect affects not only HPV, but also the causative agents of mononucleosis, influenza, herpes and other diseases.

Pharmacological action of the drug

The drug primarily increases the activity of T-lymphocytes, which are the main cells of the human immune system. The main task of lymphocytes is to find and destroy cells in the body that are infected with viruses.

Isoprinosine helps T-lymphocytes mature and become active more quickly, which helps improve the immune system. The effect of the immunomodulator is based on the increased production of interferon, a special substance that appears in the body when foreign viruses are introduced.

Interferon increases the body's ability to resist pathogenic viruses and bacteria. The body can cope with the papilloma virus faster if a person takes Isoprinosine.

• I had papillomas on my body for a long time, which I even got used to, since they were very small. But soon the doctor found a condyloma in my vagina. I was very scared because I knew that this threatened cervical cancer. I was prescribed Isoprinosine, which I took for 15 days. After that, I was examined by a gynecologist and no condyloma was found. A month after taking the pills, the papillomas on my arm began to disappear until they disappeared completely. I am very pleased with this drug.
• Since childhood, I have suffered from warts, which I used to always burn off. Isoprinosine helped me deal with my warts as they simply disappeared after taking these pills.
• I constantly suffered from papillomas, as they simply attacked me. Even cauterization could not achieve the desired effect. You remove them from one place and they pop up in another. Laser is too expensive a procedure for me, so this method is definitely not suitable. I decided to use Isoprinosine and received permission from my doctor to use it. After a month of taking it, I began to notice that the papillomas had almost all disappeared.

Isoprinosine is an effective drug for the treatment of papillomas and condylomas, as well as other skin formations. It has a pronounced antiviral and anti-inflammatory effect.

In addition, this drug helps improve immunity and strengthen the body's defenses in the fight against the virus. The advantage of Isoprinosine is also that it prevents the development of secondary infection, which usually happens after the use of other similar drugs.

Due to the high effectiveness of the drug, it is very popular among doctors and patients.

Isoprinosine has a gentle effect at the cellular level, activating the immune system and inhibiting the virus by eliminating its components from the ribosomes. The medicine eliminates the ribonucleic acid of the virus, replacing it with a healthy analogue.

Thus, the disease is actively fought in the affected cells, while the proliferation of agents is stopped, which prevents further spread of the disease.

Pharmacodynamics

The drug increases cellular immunity to normal levels through the formation of a sufficient number of T-lymphocytes. This allows you to obtain a rapid lymphoproliferative response and destroy viral agents.

Moreover, Isoprinosine helps increase the amount of immunoglobulin G and synthesizes interleukin. While taking the drug, the active substances contribute to the inhibition of virus synthesis by replacing the viral RNA in the polyribosomes of the damaged cell with normal inosinorotic acid.

Pharmacokinetics of the drug

The drug is taken in a dose of at least 1.5 g of C. This amount ensures an increase in inosine pranobex in plasma to 600 mcg per milliliter within an hour. This amount in the blood is sufficient to provide an immune response to pathogenic agents. The substance is then metabolized in the liver, producing uric acid.

HPV? What is human papillomavirus, why is it dangerous and how to treat it? My history. HPV type 16. Is HPV completely curable? Isoprinosine and its SIDE effects.

If you opened my review, then you are most likely familiar with such a thing as HPV. (Human papillomavirus). You don’t have to be infected with it; now in many antenatal clinics/hospitals there are entire posters and stands dedicated to this problem and you can observe them.

The papilloma virus, entering the body, takes root there firmly and for a long time, settling in the cells of the epidermis. In the presence of low immunity or under other circumstances, for example, taking immunosuppressants, the body’s defenses are reduced, and the pathogen provokes uncontrolled proliferation of the epithelium.

Treatment of HPV with Groprinosin is the most effective component of complex therapy, which, in addition to systemic immunomodulators, includes methods for the destruction of already existing pathological growths. This is a serious drug that should not be taken without consulting a doctor.

How does Groprinosin work for HPV?

The drug, unlike many other similar ones, has a specific (direct) antiviral effect aimed at inhibiting the synthesis of RNA of the pathogen. This occurs due to inosine pranobex in the composition of the drug.

MINISTRY OF HEALTH OF THE RF: Papillomavirus is one of the most oncogenic viruses. Papilloma can become melanoma - skin cancer!

Groprinosin exhibits an indirect antiviral effect in the treatment of HPV through immunomodulatory and interferon-inducing effects.

Other pharmacological effects:

• Increased activity of macrophages (cells with phagocytic function);
• Stimulation of proliferation of T- and B-lymphocytes;
• Stimulation of cytokine synthesis (interleukin-1, -2).

It is necessary to take Groprinosin for papillomavirus in a course of several weeks, 2 tablets 3 times a day (each dose after meals). Based on the fact that papillomatosis manifests itself differently, and even more so, each patient’s viral load varies, the specialist can adjust the duration of therapy and the frequency of taking the drug.

Features of application

According to the instructions, if there are growths on the body or mucous membranes, as well as in the event of indirect symptoms of the presence of papillomavirus in the body, the use of the drug is permissible for patients starting from the age of three. The treatment regimen for the disease itself does not depend at all on what type of HPV is present in the body.

If you and your doctor decide that Isoprinosine will be the best choice for treating papillomavirus, you will need to understand one more issue - the use of tablets. Uncontrolled use will not give the desired result. Therefore, it is better to follow certain recommendations.

1. In case of HPV infection, Isoprinosine is only allowed to be taken by persons over 3 years of age.
2. An overdose, that is, consuming more Isoprinosine than the instructions provide, can lead to side effects and health complications.
3. Isoprinosine is equally important to use for all types of warts and the degree of their manifestation on the body. The tablets help to cope with both ordinary growths on the arms or legs, as well as genital warts, papillomas on the mucous membranes, etc.
4. The optimal effect is achieved by combining the use of Isoprinosine with methods of removing tumors, treating them with antiviral or cauterizing agents.
5. The standard pill regimen for an adult with HPV includes 2 tablets 3-4 times a day. A person takes from 6 to 8 tablets per day. The minimum duration of the course is 2 weeks.
6. After completing the course of taking pills, which can be no more than 4 weeks, you should take a break for 30 days, after which, if necessary, take a second course.
7. Children over 3 years of age are prescribed the drug in the amount of 0.5 tablets three times a day if their body weight is 15-20 kg. If the child weighs over 21 kg, then 0.5 tablets are given 4 times during the day.

The presented tablets for the treatment of papillomavirus have clearly proven their effectiveness. Therefore, their widespread use and effectiveness allow us to talk about the drug as one of the best for HPV.

Isoprinosine is very popular in the treatment of human papillomavirus infection, which has more than 100 varieties, from common warts to malignant diseases. It is impossible to completely cure the papilloma virus, but it is quite possible to cope with its pronounced manifestations.

When treating warts, Isoprinosine is used in combination with other drugs; the effectiveness of such treatment is confirmed by numerous positive reviews from patients.

Warts are one of the types of human papillomavirus infection. According to statistics, warts can very rarely become malignant tumors. They appear on the body in single quantities or in multiple clusters. Often, a wart goes away on its own - this means that the person’s immune system has strengthened and is able to cope with the disease on its own.

However, with low immunity, numerous warts may appear near a single wart, which does not look very nice. Even their complete destruction does not guarantee that warts will not appear again. In such cases, the doctor prescribes Isoprinosine, which reduces the likelihood of relapse.

The drug can be used both before and after removal of papillomas. Depending on the individual characteristics of the body, after taking the medicine, neoplasms may disappear on their own, without requiring surgical intervention. If you do have to remove warts, Isoprinosine reduces the risk of their reappearance.

Most often, Isoprinosine is prescribed for patients with weak immunity that cannot resist the following diseases:

• Papillomavirus;
• Flu and ARVI;
• Smallpox virus;
• Herpes;
• Molluscum contagiosum;
• Infectious mononucleosis.

• The drug should be taken for three weeks, then a break of one month is taken.
• If the disease relapses, the duration of use increases and is as follows: treatment for 1 month, then a break of about four weeks, then the use continues. The general course of therapy should be at least three months.
• To achieve greater treatment effectiveness, it is recommended to use Isoprinosine in combination with other types of therapy: laser removal of warts, the use of ointments and creams. This comprehensive approach will help avoid further relapses.

Isoprinosine for warts is used in the following way:

• Adults: 2 tablets three times a day.
• Children: 50 mg per 1 kilogram of child’s weight per day. For example, if the child weighs 30 kilograms, then you need to take one tablet three times a day.

The drug Isoprinosine is available in the form of oblong tablets. One package can contain from 20 to 50 tablets. The active component of the drug is inosine pranobex, which is a substance of animal origin. Due to the main component, biochemical reactions in the body are enhanced, due to which the following occurs:

• the activity of the immune cells of the human body increases;
• interferon production increases;
• the chain of formation of microorganisms is disrupted, the production of enzymes that activate viruses is blocked.

It is necessary to take Isoprinosine tablets for a certain time, following the instructions or medical recommendations. Its negative effect on the presence of pathogenic microorganisms due to the improvement of protective functions has been noticed. In addition to the treatment of papillomas and warts caused by HPV, the drug is prescribed as a treatment for:

1. influenza, ARVI;
2. herpetic infection, including herpes zoster, herpetic keratitis, genital herpes, chickenpox;
3. molluscum contagiosum;
4. cytomegalovirus infection;
5. measles

The drug Isoprinosine is prescribed in combination with other drugs, including antivirals. It should be prescribed exclusively by a doctor, since the dosage of the drug is selected individually for each person, as is the treatment regimen.

The substance of the drug Isoprinosine is absorbed through the gastrointestinal tract, maximally manifesting itself in the blood plasma 2 hours after administration. It is excreted from the body through the kidneys and other urinary organs without any residue. Today, this remedy is one of the most effective in the fight against HPV, which can be detected even in young children.

The drug Isoprinosine helps strengthen the immune system, so that papillomas and warts do not grow, but gradually disappear. Acting on viruses from the inside, the product fights their external manifestations. Thus, the herpes virus, which often recurs in many people, can be sent into a long-term stage of remission.

In people with weak immunity, warts on the body can appear up to 5 times in 1 year. They spoil the aesthetic appearance of the skin, and when injured, they contribute to infection.

Long-term recurrent HPV can lead to serious complications, including malignant cell division. Taking Isoprinosine along with interferon according to the regimen, you can significantly increase the resistance of the immune system to various viruses.

The medicine is prescribed to people with papillomas and warts. For each patient, the dosage of the drug is selected individually. Attention is paid to the patient’s age and state of health. The dose of the medication may be as follows:

1. Adults and children under 12 years of age should take Isoprinosine three times a day. The dosage will depend on the patient's weight. You should take the tablet completely, being careful not to crush it and drink enough water;
2. Children over 3 years old can take the medicine in the amount of 1/3 tablet. The entire pill is divided into 3 doses. The halves are also washed down with a sufficient amount of drinking water.

As mentioned above, the calculation of the dosage of the medication is selected based on the weight of the sick person. For every kg there are 50 mg of medicine. It turns out that 1 tablet is intended for 10 kg of weight.

Sometimes doctors do not calculate individual dosages, but take average values. According to them, people weighing from 60 to 80 kg should drink 6-8 tablets. It is prohibited to take average values ​​when selecting a dose for small children.

If the papillomavirus is severe, then determining the optimal dosage will follow a slightly different scheme. In this case, 100 mg of medication is taken for each kg of weight. It turns out that 10 kg requires 2 tablets. If a child requires treatment, then only 50 mg of the drug is taken per 1 kg of weight. In the situation with children, the severity of the pathology is not taken into account.

Elderly patients who are over 65 years of age should be treated with Isoprinosine, adhering to the standard dosage for adults.

Regardless of where exactly the viral rash is located, the patient will need to undergo treatment for a long enough time to suppress the activity of the disease and stop its spread.

If a person is diagnosed with genital warts, he will need to take 2 courses of Isoprinosine at once. The first is carried out after removing problematic rashes. The second course begins approximately a month after completion of the previous therapy.

If taken correctly, the drug "Isoprinosine" gives a positive result for approximately 90% of patients. Relapse of the disease was recorded in only 3% of patients during the first 6 months after the end of the therapeutic course.

The results obtained convince patients to fight warts and eliminate condylomas using these tablets. Doctors are of the same opinion. “Isoprinosine” is guaranteed to help get rid of warts and papillomas, which cause discomfort and make a person feel insecure.

HPV is a fairly common phenomenon that can cause moral and, in some cases, physical discomfort to the carrier. If there is a need to eliminate the pathology, you can use Isoprinosine for the human papillomavirus - this is an effective remedy that has many advantages compared to other drugs.

Isoprinosine for papillomas - what's in it?

Externally, the tablets have an oblong shape. Available in 20 or 50 tablets. The main active ingredient of the product is inosine pranobex.

This component is of animal origin and allows you to maximize biochemical reactions in the body in a short time.

Isoprinosine is prescribed orally. The dosage depends on the patient’s age and weight and is calculated individually in accordance with general health indicators and characteristics of the disease. For children under 12 years of age, 1 tablet per 10 kg of weight is prescribed. The daily dose should not exceed 1 g. For adolescents and adults, the drug is prescribed 1.5-2 tablets every 6-8 hours.

The entire course of treatment lasts from 5 days to two weeks. Chronic diseases require the use of the drug for a month, after which a break is taken for 60 days. For the treatment of recurrent diseases, such as human papillomavirus, the duration of administration is 14-30 days, 2 tablets every 8 hours.

Interaction with other tools

In the treatment of HPV, Isoprinosine is used in combination with ointments to eliminate papillomas, with immunostimulants and other medications. These are perfectly acceptable combinations.

It is not advisable to combine this drug with diuretics, as this increases the load on the kidneys. It is prohibited to use immunosuppressants during treatment with Isoprinosine.

It should also be remembered that the combination of this drug in combination with azidothymidine provokes an increase in phosphorylation in cells.

Available analogues

Well-known drugs that can replace Isoprinosine are: Groprim, Novirin, Groprinosin, Normomed, etc. They actively fight viruses, relieve symptoms, and prevent the development of the disease. The release forms of these drugs are either tablets, suspensions and syrups. Taken orally, the dosage is prescribed by the doctor.

The widespread prevalence of HPV among middle-aged and young people raises serious concerns among doctors around the world. There is an assumption that about 70% of girls are infected.

It is impossible to analyze the situation and draw accurate conclusions, since many do not even suspect that they are infected with the virus and do not take any action to treat it. To date, no medicine has been invented that will completely cure this disease, but there are many effective modern drugs that help the body suppress harmful cells.

Isoprinosine received good reviews for papillomas.

What effect does the drug have on papillomavirus?

Panavir is a Russian-made antiviral drug. Used to treat HPV infections, influenza and acute respiratory viral infections, herpes and other viral diseases.

Briefly about the drug

Panavir is an extract from the plant “Tuberous nightshade” (in Latin Solanum tuberosum), or ordinary potato (see Wikipedia).

Panavir has a direct effect on viruses, suppressing their growth and reproduction at all stages of development. The drug stimulates white blood cells to produce their own interferon, which also kills viruses.

Interesting fact: all green parts of potatoes are poisonous - leaves, berries, green tubers. They produce a toxic substance - solanine.

Contraindications

Side effects

Among the contraindications, kidney disease takes the leading place. It is not recommended to use the tablets for gout, kidney failure, or kidney stones. People suffering from an increased allergic reaction to many medications should also use Isoprinosine with caution. Do not forget about individual intolerance to the drug.

It is not advisable for infants to use this drug, since no precise laboratory studies have been conducted in this area. Studies with the participation of pregnant women have also not been conducted, so during pregnancy it is better to replace Isoprinosine with another medicine.

Isoprinosine is widely used in the treatment of warts. It has antiviral and immunomodulatory properties, which helps to increase the effectiveness of treatment.

The drug helps get rid of papillomas and also reduces the likelihood of their reappearance after surgical removal. Doctors recommend using tablets only after a medical examination, and not self-medicating.

Numerous positive reviews indicate positive results of treatment.

Related Posts

Isoprinosine copes with various infections that are viral in nature. It is prescribed to patients suffering from the following diseases:

• Respiratory infections;
• Mononucleosis;
• Herpes;
• Measles;
• Molluscum contagiosum;
• Papillomavirus;
• Genital warts;
• Warts.

The drug fights well against those infections that suppress the activity of the immune system, leaving the body unprotected against their attack.

Isoprinosine is contraindicated for use in a number of diseases due to the threat of worsening the patient's condition. This is due to the fact that the drug during metabolism increases the load on the kidneys and liver, which can cause disruptions in the rhythm of the heart and its functioning.

Diseases and conditions for which the drug should not be taken:

1. Urolithiasis disease. The main active ingredient during excretion promotes increased formation of sparingly soluble acid and salts, which can cause serious complications in the functioning of the urinary system.
2. Gout. Excess uric acid can lead to severe forms of the disease.
3. Arrhythmia.
4. Chronic liver and kidney failure. Due to the breakdown products of the active substance of the drug, the load on these vital organs increases.
5. Hypersensitivity to the components of the drug. This is an absolute indication for cancellation.

Many of these diseases can be asymptomatic, so before treating HPV with Isoprinosine, it is necessary to identify disturbances in the body’s functioning. Many people begin to take medication for papillomas on their own, after which they suffer from negative reactions and consequences.

There are no officially registered cases of overdose. Reviews do not contain information about this phenomenon. Theoretically, a drug taken in an excessive dosage can cause an increase in the concentration of uric acid in the urine and blood. Therapy is aimed at eliminating symptoms.

"Isoprinosine" helps cope with the infection. But not all people who are affected by the human papillomavirus can afford to undergo treatment based on this drug. This is because it, like any other medicine with a huge number of chemicals, has a number of contraindications. Patients with papillomavirus who are characterized by the following conditions are prohibited from taking the medicine:

• Gout;
• Tendency to allergies;
• Heart rhythm disturbances;
• Pregnancy;
• Lactation;
• Stones in the kidneys or bladder.

The drug should be taken with caution in patients who have difficulty excreting uric acid. They should check their blood urate levels regularly. Such control will allow you to avoid negative reactions while taking Isoprinosine.

Isoprinosine should not be prescribed for gout, urolithiasis, and the use of the drug for chronic renal failure and diseases of the cardiovascular system (arrhythmias) is prohibited. The medication should not be prescribed to children under 3 years of age and in cases where the child’s weight is less than 15 kg.

Contraindication for use is hypersensitivity or individual intolerance to the components of the drug.

Isoprinosine and alcohol

Alcohol is not compatible with Isoprinosine, so during the entire course of therapy you should refrain from drinking drinks containing even a small amount of ethyl alcohol. This incompatibility of Isoprinosine with alcohol is due to several factors.

Firstly, alcohol increases the side effects of Isoprinosine and increases the risk of their development. This means that when taking alcohol and a drug in combination, a person is highly likely to develop arrhythmia, renal colic, renal failure, pyelonephritis or allergic reactions.

Secondly, Isoprinosine has a strong effect on the liver, which is also subject to very noticeable stress when drinking alcohol. Thus, the combination of Isoprinosine alcohol is very toxic and harmful to the liver, as it can provoke jaundice, cholestasis, hepatitis and other disorders of the organ.

Thirdly, Isoprinosine increases the production of interferon, which, in turn, enhances the negative effects of alcohol on the human body. If you take Isoprinosine for several days in a row while drinking alcohol, you may develop psychopathology (depression, suicidal thoughts) and disorders of the peripheral nervous system (numbness, tingling of the extremities, etc.).

etc.), due to the several times increased harmful effects of ethyl alcohol. Thus, Isoprinosine cannot be combined with alcohol.

Analogues and prices

Prices for the immunostimulating drug Isoprinosine directly depend on the number of tablets in the package. Manufacturers produce the medicine in packages of 10, 20, 30 and 50 pcs. In most chain pharmacies, the cost of the drug ranges from 264-349 rubles. (124 – 164 UAH) for a pack of 10 tablets.

Since the drug is quite expensive, many people are looking for cheaper analogs of the drug. But at the same time, only Groprinosin and Novirin are drugs containing the same active substance (inosine pranobex). Their cost differs significantly from the prices for Isoprinosine and ranges from 101-124 rubles. (47-58 UAH) per pack of 10 tablets.

In the treatment of HPV, other analogues of Isoprinosine, containing other active ingredients, can be used as an immunomodulator. Such drugs include:

• Lycopid;
• Viferon;
• Panavir;
• Genferon.

Among all analogues with a different composition, the most effective is the drug Allokin. The medicine is produced exclusively in the form of powder for injection. It is prepared immediately before the injection by diluting the contents of the ampoule with 1 ml of saline sodium chloride solution. The effectiveness of treating HPV with this drug is 98%, while the duration of the course does not exceed 6 injections.

The only drawback of this drug is its price. In the cheapest pharmacy, a package of 3 Allokin ampoules will cost at least 4166 rubles. (1958 UAH).

Prices for other Isoprinosine analogues start from 426 rubles. (200 UAH).

The drug can be purchased at prices ranging from 540 to 715 rubles per package containing 20 tablets. The cost of Isoprinosine is influenced by the pricing policy of the pharmacy, as well as the manufacturer.

The site provides reference information for informational purposes only. Diagnosis and treatment of diseases must be carried out under the supervision of a specialist. All drugs have contraindications. Consultation with a specialist is required!

Composition, release forms and names of Isoprinosine

Isoprinosine tablets contain the following substances as auxiliary components:

• Mannitol;
• Wheat starch;
• Magnesium stearate.

In everyday speech, qualified names are often used to refer to this drug, such as Isoprinosine 500, Isoprinosine 50, Isoprinosine 30 etc. In these names, the number 500 means the dosage of the active component of the drug. And the numbers 30 and 50 mean the number of tablets in the package. Such markings allow doctors, pharmacists and patients to quickly understand exactly how many tablets are needed.

Therapeutic effect

Stimulation of the immune system by Isoprinosine occurs due to the activation of the production of interleukins 1 and 2, as well as interferon gamma, which have anti-inflammatory activity. In addition, the production of interleukins 4 and 10 decreases, which, on the contrary, maintain and enhance inflammation in various organs and tissues. As a result of this modulation of the production of interleukins and interferon, the intensity of the inflammatory process in any tissue or organ decreases, as a result of which the lesion decreases and the normal cell structure is restored.

In addition, Isoprinosine activates the work of cytotoxic T-lymphocytes and natural killer cells (NK cells), which destroy cells damaged by viruses, which also leads to a reduction in the size of the inflammatory focus and restoration of the structure of an organ or tissue. In parallel with the increase in the activity of cytotoxic T-lymphocytes and NK cells under the influence of Isoprinosine, there is an increase in the production of T-suppressors and T-helpers, which help other cells of the immune system to “recognize” and destroy viruses or cellular structures affected by them. Separately, it should be noted that under the influence of Isoprinosine, the production of IgG antibodies increases, which also contribute to the destruction of virus-infected cells.

All of the listed components of activation of the immune system (increased activity of cytotoxic T-lymphocytes, NK-cells, T-helpers, T-suppressors, as well as the production of IgG, interleukins 1 and 2 and interferon gamma), aimed at destroying viruses, are implemented in the systemic bloodstream. That is, all these cells and substances end up in the blood, which flows to the affected organ or tissue. And when the blood flow delivers all the listed cells and substances to the required area, they are released and penetrate into the thickness of the tissue, where they exert their effect.

In addition to reactions of activation of the immune system that occur in the bloodstream, there are other processes that occur directly in the thickness of the affected tissues or on the mucous membranes. The reactions of the immune system in the thickness of tissues and on mucous membranes are called local immunity, and represent a very important link in the overall mechanism for the destruction of viruses and cells affected by them. After all, local immunity destroys viruses and affected cells constantly, without waiting for a massive reaction in the systemic bloodstream and, thereby, prevents pathogenic microorganisms from quickly infecting a large area of ​​tissue or organ. Under the influence of Isoprinosine, local immunity is activated, which is manifested by the accumulation of a large number of monocytes, macrophages and neutrophils in the affected area of ​​the organ, which destroy cells infected with viruses.

The direct effect of Isoprinosine on viruses is that the drug suppresses their reproduction by blocking the enzyme. dihydropteroate synthetase. In laboratory experiments Isoprinosine successfully inhibits the reproduction of the following viruses:

• Herpes simplex types 1 and 2;
• Cytomegalovirus;
• Measles virus;
• Human T-cell lymphoma virus type III;
• Polioviruses;
• Influenza viruses types A and B;
• ECHO virus (human enterocytopathogenic virus);
• Encephalomyelocarditis virus;
• Equine encephalitis virus.

Indications for use

• Influenza and other acute respiratory viral infections;
• Herpetic infections caused by Herpes simplex viruses types 1, 2, 3 and 4 (labial and genital herpes, herpes keratitis);
• Herpetic infections caused by the Varicella zoster virus - chickenpox and herpes zoster;
• Cytomegalovirus infection;
• Infections caused by the Epstein-Barr virus (infectious mononucleosis);
• Human papillomavirus infection in various manifestations, such as papillomas of the larynx, vocal cords, genital organs in men and women, as well as genital warts and warts of any localization;
• Molluscum contagiosum;
• Measles.

Isoprinosine - instructions for use

Dosage calculation for children and adults

• – the dosage is calculated individually according to body weight, based on the ratio of 50 mg per 1 kg of weight per day. That is, if an adult’s body weight is 70 kg, then the daily dosage of Isoprinosine for him is 70 * 50 = 3500 mg, which corresponds to 7 tablets (3500/500). This calculated number of tablets is divided into 3 to 4 doses per day. Adults may not calculate the dosage of Isoprinosine individually, based on the fact that the average daily dose of Isoprinosine for a person with normal body weight (60–80 kg) is 6–8 tablets. In addition, you can use a simplified version of calculating the daily dosage of Isoprinosine - 1 tablet for every 10 kg of weight.
• Children 3 – 11 years old– the dosage is calculated individually according to body weight, based on the ratio of one tablet for every 10 kg of weight per day. That is, if a child’s body weight is 35 kg, then he should take 3.5 Isoprinosine tablets per day. The total daily amount of the drug for children is divided into 3–4 doses.

For children aged 3 to 11 years, the maximum daily dosage of Isoprinosine should not exceed the ratio of 50 mg per 1 kg of weight, regardless of the severity of the disease. For example, if a child weighs 20 kg, then he needs to take 2 tablets per day, which is 1000 mg. To check whether a given dosage does not exceed the maximum permissible, you should divide it by the child’s body weight - in our example, 1000/20 = 50. Then the resulting figure must be compared with 50, and if it is less, it means that the dosage is below the maximum permissible norms. If the resulting figure is more than 50, then the dosage of Isoprinosine is greater than the maximum allowable norm for a child. In this case, the dosage should be reduced. In our example, the calculated dosage is equal to the maximum permissible for a child, so it can be used.

Elderly people (over 65 years of age) should take Isoprinosine at normal adult dosages without reducing them.

The duration of use of Isoprinosine in individually calculated dosages is entirely determined by the type of disease.

Reception for acute acute respiratory viral infections, influenza, measles, molluscum contagiosum and infectious mononucleosis

Use for chronic diseases with recurring exacerbations (genital and labial herpes, herpes zoster, infection caused by cytomegalovirus)

In addition, it is possible to use another treatment regimen, which consists of taking Isoprinosine in an age-specific individual dosage until the symptoms of exacerbation of the disease completely disappear. Then the drug should be continued to be taken at the same dosage for another two weeks, which is necessary to achieve stable remission.

Reception for any herpetic infection (chickenpox, herpes keratitis, genital or labial herpes, herpes zoster)

Reception for papillomas of any localization, human papillomavirus infection or genital warts

• Adults and teenagers over 12 years old – take 2 tablets 3 times a day.
• Children 3 – 11 years old– the daily dosage of Isoprinosine is calculated individually according to the ratio: one tablet for every 10 kg of the child’s weight. The calculated total dosage of the drug is divided into 3–4 doses per day and given to the child for 14–28 days.

Isoprinosine for HPV

Use during pregnancy and breastfeeding

special instructions

With long-term use of Isoprinosine, the cellular composition of peripheral blood should be monitored every 4 weeks by calculating the leukoformula as part of a general blood test, and also monitor the functioning of the liver and kidneys by determining the activity of AST and ALT, as well as the concentrations of creatinine and uric acid in the blood.

In addition, it is necessary to frequently (at least once a week) monitor the concentration of uric acid in the blood when using Isoprinosine concomitantly with drugs that impair kidney function or promote the accumulation of uric acid.

Impact on the ability to operate machinery

Overdose

Interaction with other drugs

Drugs from the groups of xanthine oxidase inhibitors (for example, Allopurinol, Zilorik, Milurit, Purinol, Allopin, etc.) and uricosuric drugs (salicylates, including Aspirin, Probenecid, Benemid, Sulfinpyrazone, diuretics, etc.) increase the risk of increasing urinary concentrations acids in the blood and the development of gout.

With the simultaneous use of Isoprinosine with Acyclovir and Zidovudine, the antiviral effect of the latter is enhanced.

Isoprinosine for children

As a rule, the drug is used for children to treat acute viral infections (ARVI, influenza, measles, chickenpox, molluscum contagiosum, infectious mononucleosis) or recurrent diseases associated with the herpes virus (for example, herpes on the lip, etc.). In general, it is recommended to give the child Isoprinosine for 5 to 15 days, depending on the severity of the infection and the speed of disappearance of symptoms. In this case, it is necessary to use the rule that for acute diseases, Isoprinosine should be taken additionally within two days after the symptoms disappear, and for chronic recurrent infections, this should be done within two weeks after the exacerbation has stopped. In addition, after stopping a relapse of a chronic infection, you can give Isoprinosine to a child 1 tablet per day for 30 days, and not in full dosage for two weeks.

The widespread prevalence of HPV among middle-aged and young people raises serious concerns among doctors around the world. There is an assumption that about 70% of girls are infected. It is impossible to analyze the situation and draw accurate conclusions, since many do not even suspect that they are infected with the virus and do not take any action to treat it. To date, no medicine has been invented that will completely cure this disease, but there are many effective modern drugs that help the body suppress harmful cells. Isoprinosine received good reviews for papillomas.