Ergocalciferol instructions for use. The drug ergocalciferol regulates calcium-phosphorus metabolism. Video: "What does vitamin D deficiency lead to?"

Vitamin D is called the “sun vitamin” because it is almost not found in food and is produced under the influence of sunlight.

A person with vitamin D deficiency often gets sick (including diseases of the musculoskeletal system), experiences muscle pain, feels overwhelmed and depressed.

People who live in the north or rarely go outside (office workers, pensioners, and people working night shifts) are at risk.

To compensate for the existing deficiency, vitamin D2 preparations are prescribed, such as Ergocalciferol.

The medicine can be used by children and adults, but only with the permission of the doctor.

Instructions for use

pharmachologic effect

Ergocalciferol (D2) regulates calcium and phosphorus metabolism, ensures their absorption in the intestines. The effect of the drug is enhanced when phosphorus and calcium compounds enter the body. The specific effect of D2 is especially pronounced in rickets, which is why it is called an antirachitic vitamin.

12-24 hours after taking Ergocalciferol, blood calcium levels increase. After 10-14 days, a therapeutic effect is observed, which lasts up to 6 months.

Release form, composition

The active component of the drug is ergocalciferol (vitamin D2). The medicine also contains refined soybean oil.

The drug is available in the form of a transparent oily liquid of light or dark yellow color. There is no rancid smell. The liquid is sold in bottles packed in cardboard boxes.

Indications for use

Ergocalciferol is used for:

• hypo- and vitamin D deficiency (for treatment and prevention);
• pseudohypoparathyroidism, hypoparathyroidism (idiopathic, postoperative, tetany);
• taking mineral oils, barbiturates, anticonvulsants (including primidone, phenytoin);
• increased need for vitamin D: with rickets, osteomalacia, spasmophilia, osteoporosis, unbalanced and inadequate nutrition (including parenteral, vegetarian diet), nephrogenic osteopathy, hypocalcemia, alcoholism, liver failure, insufficient insolation, cirrhosis, hypophosphatemia, obstructive jaundice , malabsorption, gastrointestinal diseases (gluten enteropathy, tropical sprue, persistent diarrhea, Crohn's disease).

Directions for use, dosage

Take Ergocalciferol with meals. It should be taken into account that 1 ml of the drug contains 50,000 ME, and 1 drop from an eye dropper contains 1,400 ME.

Ergocalciferol dosage with rickets depends on the severity of the disease and the nature of its clinical course. The medicine is used at 1400-5600 IU per day for 30-45 days. When a therapeutic effect can be achieved, the drug is used in a prophylactic dose of 500 IU. Vitamin D2 is not taken during the summer months.

Nursing and pregnant women Ergocalciferol is prescribed for the prevention of rickets in infants and newborns. The medicine is taken starting from 30-32 weeks of pregnancy, 1400 IU per day. Course duration is 6-8 weeks. During lactation, the vitamin is taken from the first day of feeding until the drug is prescribed to the child. The daily dose for nursing mothers is 500-1000 IU.

Full-term babies Ergocalciferol is prescribed for the prevention of rickets from the 3rd week of life. In some cases, the medicine is used starting from 2 weeks. This applies to premature babies, twins, as well as children who are bottle-fed and/or living in unfavorable environmental (including household) conditions.

For preventive purposes, the vitamin is used as follows::

• physiological method - full-term children daily for 3 years (except summer months) 500 IU per day;
• course method - at 2-6-10 months of life, 1400 IU daily for 30 days, then up to 3 years, 2-3 courses per year with intervals between courses of 3 months.

In both cases, the course dose of the drug per year is 180,000 IU.

When treating premature babies the daily prophylactic dose can be increased to 1000 IU. This amount of the drug is taken daily for the first 6 months of life. Then the child is given 1400-2800 IU per day for a month. Courses are repeated 2 or 3 times a year. The intervals between courses are 3-4 months.

In the presence of long winters, prevention is carried out until the child is 3-5 years old. During treatment, monitoring calcium levels in the urine is mandatory.

For rickets-like diseases and pathological lesions of bone tissue caused by calcium metabolism disorders, the medicine is prescribed in combination with other drugs.

Interaction with other drugs

Possible interactions of Ergocalciferol with other medications are described below:

• with calcium salts – increased toxicity of vitamin D2;
• with iodine preparations – oxidation of vitamin D2;
• with antibiotics (neomycin, tetracycline) – impaired absorption of ergocalciferol;
• with mineral acids – destruction, inactivation of vitamin D2;
• with barbiturates (including phenobarbital), primidone, phenytoin - increased need for ergocalciferol, increased osteomalacia or severity of rickets;
• with thiazide diuretics and medications containing calcium - increased risk of developing hypercalcemia, decreased tolerance to cardiac glycosides, delayed elimination of ergocalciferol and its accumulation in the body;
• with antacids containing aluminum and magnesium ions - increased concentration of antacids in plasma, risk of intoxication (especially in people with chronic renal failure);
• with calcitonin, plicamycin, pamidronic and etidronic acids, gallium nitrate, glucocorticosteroids - decreased effectiveness of ergocalciferol;
• with cholestyramine, mineral oils, colestipol - decreased absorption of fat-soluble vitamins (including D2) in the digestive tract;
• with isoniazid, rifampicin, antiepileptic drugs - decreased effectiveness of ergocalciferol;
• with drugs containing phosphorus - increased absorption of these drugs, risk of developing hyperphosphatemia;
• with vitamin D analogues – the risk of developing hypervitaminosis.

Caution must be exercised when taking Ergocalciferol simultaneously with cytochrome P450 inhibitors, ketonazole.

Video: "What does vitamin D deficiency lead to?"

Side effects

Adverse reactions possible with long-term use of the vitamin in high doses:

If the above effects develop, the medicine is discontinued and the intake of calcium into the body is limited as much as possible (including with food).

Overdose

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Next fact

Excess vitamin D2 leads to loss of appetite, changes in the composition of urine, increased calcium levels in the urine and blood, sleep disturbances, and the development of calcification of soft tissues, lungs, kidneys, and blood vessels. Headaches, irritability, fever, nausea, and general weakness also appear. Overdose treatment should be symptomatic.

Contraindications

Ergocalciferol is not used for hypercalcemia, pregnancy (in patients over 35 years of age), renal osteodystrophy with hyperphosphatemia, individual intolerance to vitamin D2, active form of tuberculosis.

Restrictions on the use of the drug are: organic heart damage (decompensation stage), old age, gastrointestinal, kidney and liver diseases.

During pregnancy, lactation

Experiments on animals have demonstrated that calcitriol in doses 4-15 times higher than recommended for humans has a teratogenic effect.

The presence of hypercalcemia in a woman (associated with prolonged overdose of Ergocalciferol during pregnancy) can cause in the fetus:

• hypersensitivity to vitamin D;
• mental retardation;
• syndrome of specific elf-like appearance;
• dysfunction of the parathyroid gland;
• aortic stenosis.

Therefore, during pregnancy, the vitamin is prescribed with caution. It is important to consider that Ergocalciferol and its metabolites are detected in breast milk.

special instructions

When using Ergocalciferol, you must adhere to the doses recommended by the doctor and/or manufacturer.

Vitamin D2 should be stored in conditions that exclude exposure to air and light: light converts the vitamin into toxic toxin, and oxygen oxidizes it.

It should be borne in mind that ergocalciferol has cumulative properties. With long-term therapy, it is necessary to monitor the calcium content in the urine and blood. Exceeding recommended doses can lead to the development of chronic hypervitaminosis D2.

Hypervitaminosis caused by ergocalciferol, may lead to increased effects of cardiac glycosides, increasing the risk of arrhythmia (it is necessary to adjust the dose of cardiac glycoside).

Prescribing the drug to elderly people and people with hypothyroidism (for long-term therapy) requires caution. This is due to the ability of ergocalciferol to enhance calcium deposits in blood vessels, kidneys and lungs, and contribute to the intensification and development of atherosclerosis.

Patients using D2 in large doses need to take ascorbic acid, B vitamins and vitamin A (10,000-15,000 IU per day) to reduce the toxic effects on the body. Combining Ergocalciferol treatment with irradiation with a quartz lamp is not recommended.

In older people, the need for ergocalciferol may increase. It is not advisable to take calcium supplements at the same time as high doses of vitamin D. During therapy, it is necessary to monitor the levels of phosphorus and calcium in the urine and blood.

For patients with immobilization and people suffering from diabetes, the medicine is prescribed with caution.

Individual vitamin D2 needs should take into account all sources of ergocalciferol. The drug contains butylated hydroxytoluene.

Impact on the ability to drive vehicles and operate machinery

During therapy, adverse reactions from the central nervous system may occur, so the patient should exercise caution.

Use in pediatrics

For children born full-term, the medicine is prescribed from 3 weeks according to the regimen specified by the pediatrician. Premature babies receive the drug from 2 weeks.

With impaired renal and hepatic function

For pathologies of the liver and kidneys, the medicine is taken with the permission of a specialist.

Conditions, shelf life

Ergocalciferol should be stored in the refrigerator (temperature - 2-8 ° C) in its original packaging. The shelf life is 2 years.

Price

Terms of sale

You can buy the medicine with a prescription.

Average price in Russia

The cost of Ergocalciferol in Russia starts from 30 rub.

Ergocalciferol (vitamin D2) is a drug that controls calcium-phosphorus metabolism and is used for the treatment and prevention of rickets, as well as in the complex treatment of osteoporosis. Active metabolites of the drug (primarily calcitriol) easily bypass the barrier in the form of cell membranes and bind to specific receptors in the cells of target organs, thereby activating the process of formation of calcium-binding proteins, facilitating the absorption of calcium and phosphorus in the small intestine, enhancing the reabsorption of these microelements in the proximal renal tubules. Under the influence of ergocalciferol, bone tissue receives a powerful additional calcium-phosphorus “recharge”, which protects it from destruction (resorption). Calcium concentration begins to clearly increase 12-24 hours after taking a single dose of the drug. A pronounced therapeutic effect is achieved on days 10-14 and lasts up to six months. Ergocalciferol is rapidly absorbed in the small intestine (in the presence of bile acids, the completeness of absorption ranges from 60 to 69%, and with D2-hypovitaminosis - 95-100%). With a reduced flow of bile into the small intestine, the intensity and completeness of absorption drop sharply. Ergocalciferol accumulates predominantly in bones, and to a lesser extent in muscles, liver, blood and small intestine. The drug lasts the longest in adipose tissue.

Ergocalciferol is available in three dosage forms: pills, drops and oil solution for oral administration. To prevent rickets in full-term infants, it is prescribed in the first year of life, starting at 3 weeks of age (with the exception of the summer period, when a short pharmacological “respite” can be taken). The total course dose of ergocalciferol for a year should not exceed 150-300 thousand ME. For premature babies and children at risk (poor living conditions and unfavorable climate), the drug is prescribed already from the 2nd week of life.

For them, the total course dose of ergocalciferol should be about 300-400 thousand ME. The daily dose for the treatment of stage I rickets ranges from 10-15 thousand ME, the duration of treatment is 30-45 days, the total dose per course is 500-600 thousand ME. Stage II of rickets requires large amounts of ergocalciferol: 600-800 thousand ME per course lasting the same 30-45 days. If the disease recurs, a repeat ten-day course of medication is carried out based on a total dose of the drug of 400 thousand IU. The time gap between courses should be at least 2 months.

A special feature of storing ergocalciferol is the complete exclusion of exposure to sunlight (light converts vitamin D2 into toxic toxin) and air (oxygen oxidizes vitamin D2). Given the fact that ergocalciferol has cumulative properties, during drug therapy it is necessary to monitor the level of calcium in the blood and urine. Sensitivity to vitamin D2 is not constant and in some patients taking even small doses can provoke hypervitaminosis. In such cases, it is necessary to stop taking the drug and limit the intake of calcium into the body (make adjustments to the diet). If large doses of the drug are indicated for the patient, then retinol, B vitamins and ascorbic acid are prescribed along with ergocalciferol, and phosphates are prescribed for premature infants. In the prevention of D2-hypovitaminosis, it is recommended to focus, first of all, on a balanced diet, and only then on pharmacotherapy. In elderly patients, the need for ergocalciferol may increase. This is explained by a decrease in the absorption of vitamin D2 in the intestines, a partial loss of the skin’s ability to reproduce provitamin D2, a reduction in the time the skin is exposed to sunlight, and impaired renal function.

Pharmacology

Vitamin D 2, regulator of calcium and phosphorus metabolism. Increases the permeability of the intestinal epithelium for calcium and phosphorus, ensuring the necessary concentrations in the blood. Regulates the mineralization of bone tissue, as well as the process of mobilization of calcium from bone tissue. Promotes the reabsorption of phosphates in the renal tubules. Has cumulative properties.

Pharmacokinetics

Release form

10 pieces. - contour cellular packaging.
10 pieces. - contour cell packaging (5) - cardboard packs.
100 pieces. - polymer cans (1).
100 pieces. - polymer jars (1) - cardboard packs.

Dosage

For oral or intramuscular administration, the daily dose varies from 10 mcg to 5 mg; The treatment regimen depends on the indications. For external use, the dose is determined individually.

Interaction

The effectiveness of ergocalciferol may be reduced during treatment with barbiturates or anticonvulsants. Can be used in combination with retinol.

The toxic effect is weakened by vitamin A, tocopherol, ascorbic acid, pantothenic acid, thiamine, riboflavin, pyridoxine.

Thiazide diuretics increase the risk of hypercalcemia.

With hypervitaminosis caused by ergocalciferol, the effect of cardiac glycosides may be enhanced due to the development of hypercalcemia (adjustment of the dose of cardiac glycoside is advisable).

Side effects

Possible: nausea, vomiting, headache, weakness, irritability, weight loss, increased urination, tissue calcification.

Rarely: heart rhythm disturbances.

Indications

For systemic use: prevention and treatment of rickets; disorders of calcium metabolism (including hypoparathyroidism, pseudohypoparathyroidism), accompanied by tetany, osteopathy, spasmophilia; osteoporosis, osteomalacia.

For external use: first and second degree burns (including sunburn), dermatitis accompanied by dry skin and peeling; baby diaper rash, diaper rash; prevention and treatment of cracked nipples (in the third trimester of pregnancy and lactation); to improve the healing of abrasions, scratches, and small wounds.

Contraindications

Hypercalcemia, active form of pulmonary tuberculosis, peptic ulcer of the stomach and duodenum, acute and chronic diseases of the liver and/or kidneys, organic heart damage.

Features of application

Use during pregnancy and breastfeeding

When prescribing ergocalciferol for therapeutic purposes to a nursing mother, breastfeeding is not recommended (to avoid the development of hypercalcemia in the child).

To prevent rickets in newborns and infants, it is possible to prescribe ergocalciferol during pregnancy and lactation (breastfeeding). The dosage regimen is set individually. Use with caution in pregnant women over 35 years of age.

Use for liver dysfunction

Use for renal impairment

special instructions

Included in the preparations

A.11.C.C Vitamin D and its derivatives

A.11.C.C.01 Ergocalciferol

Replenishes vitamin D deficiency, regulates calcium-phosphorus metabolism. In the body, it forms active metabolites of vitamin D (in particular), easily penetrating through cell membranes and binding to special receptors in the cells of target organs; this initiates protein synthesis (calcium binding protein, collagen, alkaline phosphatase and others) and facilitates the passage of calcium through the intestinal wall into the blood with subsequent transport to tissues.

Under the influence of calcitriol, the development of cartilage cells in the growth zones is normalized in the bones, the synthesis of protein stroma is activated, the capture of calcium from the blood plasma and its deposition in the form of phosphates, the necessary conditions are created in the kidneys for the reabsorption of calcium, sodium, phosphates, amino acids, citrates in the proximal tubules, at the same time, a normal level of calcium in the plasma is maintained and an obstacle is created to the excessive activity of parathyroid hormone and its phosphaturic effect.

When administered orally, it is resorbed in the distal part of the small intestine by 60-90% (in case of hypovitaminosis - almost completely), it promotes absorption, and when its entry into the intestine decreases, the intensity and completeness of absorption sharply decrease. In the lymph and blood plasma, the vitamin circulates as part of chylomicrons and lipoproteins, penetrating the liver, bones, skeletal muscles, kidneys, adrenal glands, myocardium, and adipose tissue.

It undergoes biotransformation, turning into active metabolites: in the liver - into calcidiol (transport form), in the kidneys - from calcidiol to. Excreted with bile into the intestine, from which it is partially reabsorbed; Vitamin D and its metabolites are stored in adipose tissue for an especially long time. Half-lifeis 19 days. Elimination through the intestines.

• Orally: prevention and treatment of rickets, osteomalacia, psoriasis; for tuberculosis of the skin and bones, for the healing of bone tissue after fractures.
• Externally: burns, dermatitis, diaper rash; for the prevention and treatment of cracked nipples, improving the healing of scratches and abrasions.

Active form of pulmonary tuberculosis, kidney and liver diseases, peptic ulcer of the stomach and duodenum, organic damage to the heart and blood vessels, individual intolerance.

Elderly patients with hypothyroidism.

Maternal hypercalcemia (associated with prolonged vitamin overdose D during pregnancy) may cause increased sensitivity to the vitamin in the fetus D , suppression of parathyroid function, specific elf-like appearance syndrome, mental retardation, aortic stenosis.

Use in children

Fractionally 500-1000 IU during the 1st year of life, or 50 thousand IU once a week for 8 weeks, or an accelerated regimen of 300-400 thousand IU for 10-12 days. Premature babies, twins and bottle-fed children are prescribed up to 600 thousand ME per course from the 2nd week of life. Full-term babies are prescribed up to 300 thousand ME per course for prevention from 3 weeks of age.

Treatment of rickets:

I degree - 10-15 thousand IU for 30-40 days, a course of treatment requires 500-600 thousand IU;

II degree - 600-800 thousand IU per course of treatment;

III degree - 800 thousand-1 million IU per course of treatment.

Adults

Orally, 10-100 thousand IU per day, for tuberculous lupus: 100 thousand IU per day. The course of treatment is up to 6 months.

Highest daily dose: 100 thousand IU.

Highest single dose: 100 thousand IU.

Central and peripheral nervous system: headache, irritability.

The cardiovascular system: heart rhythm disturbances.

Digestive system: thirst, nausea, vomiting, weight loss, diarrhea.

Musculoskeletal system: arthralgia, ossalgia.

Allergic reactions.

Symptoms chronic overdose: anorexia, pathological demineralization of bones, calcium deposition in blood vessels, heart, kidneys, intestines.

Symptoms acute overdose: fever, headache, arrhythmia, hypercalcemia, proteinuria, leukocyturia, cylindruria.

Treatment: symptomatic, dialysis is effective.

Enhances the effect of cardiac glycosides.

Concomitant use of barbiturates and anticonvulsants reduces the effect of ergocalciferol.

Retinol, tocopherol, pantothenic acid, riboflavin weaken the toxic effect of ergocalciferol.

It must be taken into account that vitamin D 2 has cumulative properties.

With long-term use, it is necessary to monitor the concentration of calcium ions in the blood plasma and urine.

Ergocalciferol is a fat-soluble vitamin D2 of the group of regulators of vitamin and calcium-phosphorus metabolism.

Active substance

Ergocalciferol.

Release form and composition

Available in the form of white spherical dragees.

Indications for use

• vitamin D2 deficiency in patients with osteoporosis, patients with delayed consolidation of fractures, as well as in pregnant women;
• osteopathy of various origins;
• treatment and prevention of rickets and rickets-like diseases in children.

Contraindications

• hypercalcemia;
• hypervitaminosis D2;
• renal osteodystrophy and hyperphosphatemia;
• increased sensitivity.

It is prescribed with extreme caution for the following conditions:

• atherosclerosis;
• advanced age;
• active form of pulmonary tuberculosis;
• sarcoidosis or other granulomatosis;
• chronic heart failure;
• hyperphosphatemia;
• phosphate nephrourolithiasis;
• chronic renal failure;
• lactation period;
• childhood.

Instructions for use Ergocalciferol (method and dosage)

Take 1 tablet orally.

• During pregnancy, 400-500 IU per day is prescribed from the 3rd trimester (30-32 weeks). The course of treatment continues until delivery. In exceptional cases, at the discretion of the doctor, the dosage can be increased to 1 thousand IU per day.
• To prevent rickets in full-term infants, 400-500 IU is prescribed from the 3rd week of life. The course of treatment is until the age of 1 year with a break in the summer.

The dosage for premature babies is 1000 IU per day. The course of treatment begins on the 10th day of life and continues for a year. The total dosage for the entire period is 200-250 thousand IU.

For the treatment of rickets, the following dosages are prescribed:

• For grade I rickets, 2500-3000 IU per day is prescribed. The duration of treatment is 1.5-2 months.
• For the treatment of stage II–III rickets, 5-10 thousand IU per day is prescribed for 45-60 days.
• If the disease recurs, a second course of treatment is recommended after 2 months.

For the treatment of rechita-like diseases, the choice of dosage is prescribed individually for each patient.

Patients with osteoporosis and orthopedic pathology are recommended to use 3-5 thousand IU per day for a month. If necessary, a repeat course is carried out after 3 months.

Side effects

Sometimes Ergocalciferol causes side effects in the form of allergic reactions.

Overdose

In case of an overdose of Ergocalciferol, the following symptoms are observed:

• dryness and metallic taste in the mouth;
• thirst;
• headache;
• constipation, diarrhea;
• vomiting, nausea;
• asthenia;
• fatigue.

Later signs of overdose are:

• cloudy urine;
• bone pain;
• skin itching;
• high blood pressure;
• myalgia;
• gastralgia;
• drowsiness;
• changes in mood and psyche (in rare cases).

No special treatment is required. Vitamin D2 is discontinued, the patient is prescribed vitamins A, C and B, and calcium intake is limited.

Analogues

Analogs by ATC code: Ergocalciferol (Vitamin D2), Ergocalciferol (Vitamin D2) solution in oil.

Drugs with a similar mechanism of action (matching level 4 ATC code): Aquadetrim.

Do not decide to change the drug on your own; consult your doctor.

pharmachologic effect

Vitamin Ergocalciferol regulates the exchange of calcium and phosphorus in the body, improving their absorption in the intestines. The pharmacological effect of the drug in the form of an increase in calcium in the blood manifests itself within 12–24 hours after administration. The therapeutic effect of using this drug is observed after 10–14 days and lasts for 6 months.

special instructions

Vitamin D2 can accumulate in the body, so in case of prolonged therapy it is recommended to monitor the concentration of calcium in the urine and blood.

If large doses of ergocalciferol are used, vitamins A, B and C should be taken in parallel.

During pregnancy and breastfeeding

It is prescribed with special caution to pregnant women over the age of 35 years.

Contraindicated during breastfeeding due to the high risk of developing hypercalcemia in the child.

In childhood

In old age

It is prescribed with extreme caution to elderly patients.

For impaired renal function

Contraindicated in acute and chronic kidney diseases.

For liver dysfunction

Contraindicated in acute and chronic liver diseases.

Drug interactions

• The toxic effect of drugs is reduced by the following substances: vitamin A, tocopherol, ascorbic acid, pantothenic acid, thiamine, riboflavin, pyridoxine.
• Combined use with calcium-containing drugs or thiazide diuretics increases the risk of developing hypercalcemia.
• Under the influence of primidone, phenytoin and barbiturates, the body's need for vitamin D2 increases.
• The simultaneous use of ergocalciferol with antacids containing magnesium and aluminum increases their toxic effect and increases the risk of developing intoxication.
• Cholestyramine, colestipol and mineral oils reduce the absorption of the vitamin, so an increase in its dosage is required.
• Concomitant use of the drug with other medications containing vitamin D is contraindicated due to the high risk of developing hypervitaminosis.