Fluoxetine analogs without prescriptions for weight loss. Over-the-counter fluoxetine analogues and substitutes are cheaper and safer. Analogues in terms of active substance, composition, action

Fluoxetine is a strong antidepressant intended for drug therapy for obsessive and depressive conditions, which are accompanied by the presence of fears.

Systematic use of this drug helps patients overcome apathy, improve mood, normalize appetite and sleep, and reduce feelings of fear and tension.

First acquaintance with the medicine

The active ingredient of the drug is fluoxetine hydrochloride.

The pharmacological property is based on its ability to inhibit the reuptake of serotonin into the central nervous system, the main neurotransmitter called the hormone of pleasure (or happiness).

It is he who is responsible for a good mood, the absence of tearfulness, pickiness, and boredom. The therapeutic effect of the drug improves the patient’s psycho-emotional activity and does not affect blood pressure, functional activity of the heart, and does not cause drowsiness or lethargy.

The drug is prescribed for:

• obsessive states;
• various depressions;
• premenstrual dysphoria;
• alcoholism.

Pros and cons of the drug

The main advantages of the drug are:

• lack of hypnotic effect and cardiotoxic effect;
• availability in the pharmacy network;
• democratic price.

The disadvantages of the drug include the following side effects:

• allergic reaction to the main component of the drug;
• pregnancy;
• breastfeeding a baby;
• pathological processes in the liver and kidneys;
• diabetes mellitus;
• epileptic conditions.

This predominance of “cons” over “pros” is a consequence of the fact that this drug is already outdated. Today, the pharmacological industry provides patients with modern analogs of Fluoxetine, which have the ability to selectively affect the human body.

Why are people looking for fluoxetine analogs?

Price issue

Fluoxetine is not the cheapest drug (its price is about 300 rubles) and in order to save money you have to look for more affordable analogues.

Among them are Framex and Flunat - these are more affordable medications that cost from 100 to 150 rubles, and their low price is due to their less famous name.

By-effect

A high-quality and proven drug, but it has certain disadvantages, or rather a number of side effects:

• bowel dysfunction;
• infrequent headaches that appear an hour after administration;
• increased heart rate, which can lead to tachycardia;
• overdrying of the mucous membrane;
• blurred vision;
• increased sweat secretions;
• general malaise;
• Women who took the drug experienced pain in the mammary glands and menstrual irregularities (up to several weeks);
• nausea and vomiting;
• noise in ears;
• constant feeling of fatigue;
• sleep disorders;
• depression;
• acne and allergic irritations;
• broken bones;
• sexual apathy (loss of interest in sex).

The list of contraindications is quite long and that is why most people are looking for more harmless analogues. For example, it could be Flunat or Deprex. The drugs have a natural composition and a less aggressive effect on the patient’s body.

No choice

Of course, the last reason why people turn to analogues of this drug is simply its absence on the shelves in pharmacies, since Fluoxetine is a sought-after medication.

If this medicine is not available in the pharmacy, then you should turn your attention to Profluzac and Fluval, which are identical in their action and composition.

Analogues in terms of active substance, composition, action

The active substance fluoxetine hydrochloride has the following analogues:

• Apo-Fluoxetine;
• Bioxetine;
• Deprex;
• Deprenon;
• Flunate;
• Fluval;
• Fluoxetine-Canon;
• Fluoxetine-Nycomed.

Similar medications in composition and effects on the body:

• Portal, composition: fluoxetine and vitamin supplements;
• Prodep, composition: fluoxetine and calcium;
• Prozac, composition: fluoxetine and sedatives.

Unlike Fluoxetine, almost all similar drugs contain fewer impurities, which means they are more harmless.

TOP - 15 best analogues

Popular analogues:

A question of price and free access

Cheap analogues of the antidepressant Fluoxetine:

• Floxet – 150 rubles;
• Profluzak – 75 rubles.

Over-the-counter analogues of Fluoxetine:

• Portal;
• Bioxetine.

Domestic analogues:

• Portal;

Yellow film-coated tablets in blisters of 10 pieces, 1 or 2 blisters per package.

pharmachologic effect

The drug has an anorexigenic effect, eliminates depression and relieves feelings of depression.

Pharmacodynamics and pharmacokinetics

The substance fluoxetine - what is it?

The active substance of the drug fluoxetine hydrochloride is a white (or almost white) crystalline powder, sparingly soluble in water.

What is Fluoxetine?

Fluoxetine is a selective serotonin reuptake inhibitor (SNRS). The drug belongs to the pharmacotherapeutic group “Antidepressants”.

Pharmacodynamics

The medicine is intended for oral administration. The mechanism of its action is associated with the ability to selectively (selectively) and reversibly inhibit ONZS.

The antidepressant Fluoxetine has little effect on the uptake of dopamine and norepinephrine and has a weak effect on acetylcholine receptors and H1-type histamine receptors.

Along with antidepressant, it also has a stimulating effect. After taking the tablets/capsules, the patient’s feelings of fear, anxiety and mental tension decrease, mood improves, and symptoms of dysphoria are eliminated.

Wikipedia notes that the drug does not cause orthostatic hypotension, does not have a sedative effect, and is not cardiotoxic.

It takes 3 to 4 weeks to achieve a lasting clinical effect with regular use of the drug.

Pharmacokinetic parameters:

• absorption in the digestive canal is good;
• bioavailability - 60% (orally);
• TSmax - from 6 to 8 hours;
• binding to plasma proteins (including alpha (α)-1-glycoprotein and albumin) - 94.5%;
• T½hour.

The liver is involved in the metabolism of the substance. As a result of its biotransformation, a number of unidentified metabolites are formed, as well as norfluoxetine, the selectivity and activity of which are equivalent to those of fluoxetine.

Pharmacologically inactive metabolic products are eliminated by the kidneys.

Due to the fact that the substance is excreted from the body rather slowly, the plasma concentration necessary to maintain the therapeutic effect is maintained for several weeks.

Indications for use: why are tablets and Fluoxetine prescribed?

Indications for use of Fluoxetine:

• depression (especially accompanied by fears), including when other antidepressants are ineffective;
• obsessive-compulsive disorder (OCD);
• kinorexia (to reduce uncontrollable cravings for food, the drug is used as part of complex psychotherapy).

Contraindications

The drug is not prescribed for:

* After using MAO inhibitors, Fluoxetine can be used no earlier than 14 days later; MAO inhibitors after completion of treatment with Fluoxetine are prescribed no earlier than 5 weeks later.

Side effects of Fluoxetine

General disorders that occur during the use of the drug can manifest themselves in the form of hyperhidrosis, chills, fever or sensation of cold, photosensitivity, neuroleptic syndrome, alopecia, lymphadenopathy, anorexia, erythema multiforme, which can progress to malignant exudative or develop into Lyell's syndrome.

Some patients experience symptoms of serotonin toxicity, including:

From the digestive system of organs, the following are possible: diarrhea, nausea, loss of appetite, vomiting, dysphagia, dyspepsia, change in taste, pain in the esophagus, dry mouth, dyskinesia, liver dysfunction. In isolated cases, idiosyncratic hepatitis may develop.

CNS reactions to taking pills manifest themselves in the form of: bruxism, headache, weakness, sleep disturbances (night delirium, pathological dreams, insomnia), dizziness, fatigue (hypersomnia, drowsiness); disturbances of attention, processes and concentration of thinking, memory; anxiety and associated psychovegetative syndrome, dysphemia, panic attacks, suicidal thoughts and/or attempts to take one’s own life.

The possibility of developing:

Discontinuation of drug treatment may provoke withdrawal syndrome, the main symptoms of which are: sensitivity disorders, dizziness, sleep disorders, asthenia, nausea and/or vomiting, agitation, headache, tremor.

Reviews of side effects indicate that the drug is addictive when taken uncontrolled. In some cases, the addiction is so strong that a person requires professional help to treat it.

Other adverse reactions that patients mention in reviews are severe drowsiness, tremors, convulsions, loss of appetite, and nausea. However, there are people who did not experience any unwanted effects at all during treatment.

Instructions for use of Fluoxetine

The tablets are taken orally. Eating does not affect the absorption of the drug.

To relieve depressive symptoms, the medicine should be taken once a day, in the morning, at a dose of 20 mg. If clinically necessary, 3-4 weeks after the start of therapy, the frequency of doses is increased to 2 times a day. (tablets are taken morning and evening).

For patients with an insufficient response to treatment at a dosage of 20 mg/day, in some cases the daily dose is gradually increased. In this case, it should be divided into 3-4 doses. The highest dose for elderly and senile people is 60 mg/day.

Dosage for bulimic neurosis - 60 mg/day. (take one tablet 3 times a day), for OCD - depending on the severity of clinical symptoms - from 20 to 60 mg/day.

It must be taken into account that increasing the dose may increase the severity of side effects.

Maintenance dose - 20 mg/day.

When does the drug start working?

A significant improvement in the condition is usually observed after about 2 weeks of systematic use of the medicine.

How long should I take Fluoxetine?

It takes six months to eliminate depressive symptoms.

For obsessive manic disorders (OMD), the drug is given to the patient for 10 weeks. Further recommendations depend on the results of treatment. If there is no clinical effect, the fluoxetine treatment regimen is reviewed.

If there are positive dynamics, therapy is continued using an individually selected minimum maintenance dose. The patient's need for further treatment should be reassessed periodically.

Long-term - more than 24 weeks in patients with NMR and more than 3 months in patients with bulimia nervosa - has not been studied.

After completion of treatment with Fluoxetine, the active substance circulates in the body for another 2 weeks, which should be taken into account when stopping treatment or prescribing other medications.

Patients with insufficient liver/kidney function, elderly people with concomitant diseases, as well as patients taking other medications are prescribed half the dose of the drug. In some cases, it is advisable to transfer the patient to intermittent treatment.

If, after reducing the dose/discontinuing the drug, the patient's condition worsens, it is necessary to return to treatment with the previous effective therapeutic dose. A gradual dose reduction is resumed after positive dynamics appear.

If we compare Fluoxetine and Fluoxetine Lannacher or Fluoxetine and Fluoxetine OZONE, we can conclude that the instructions for use of Fluoxetine Lannacher and Fluoxetine OZONE contain recommendations similar to those listed above.

Overdose

An overdose of Fluoxetine is accompanied by: nausea/vomiting, convulsions, hypomania, anxiety, agitation, grand mal seizures.

A victim of an overdose should rinse the stomach, give sorbitol, enterosorbent and, for convulsions, diazepam. Monitoring of respiratory activity and parameters characterizing the functional state of the heart is also important. Subsequently, symptomatic and supportive therapy is carried out.

Interaction

Doubles the plasma concentration of tricyclic antidepressants, phenytoin, trazodone, maprotiline. When prescribing Fluoxetine in combination with tricyclic antidepressants, the dose of the latter should be reduced by 50%.

It may provoke an increase in the plasma concentration of Li+, which in turn increases the likelihood of developing its toxic effects. In case of simultaneous use, it is recommended to monitor the concentration of Li+ in the blood.

Use as an adjunct to electroconvulsive therapy may cause the development of prolonged epileptic seizures.

The serotonergic effects of the drug are enhanced in combination with tryptophan. The likelihood of developing serotonin intoxication increases if taken simultaneously with drugs that inhibit the MAO enzyme.

The likelihood of adverse reactions and increased depressant effects on the central nervous system increases in combination with drugs that depress the central nervous system.

Taking with drugs that are characterized by a high degree of protein binding may provoke an increase in the plasma concentration of unbound (free) drugs, as well as an increase in the likelihood of developing undesirable effects.

Terms of sale: how is Fluoxetine dispensed - with a prescription or not?

Fluoxetine cannot be purchased without a prescription.

Storage conditions

Tablets should be stored at temperatures below 25°C.

Best before date

special instructions

When treating patients with low body weight, anorexigenic effects should be taken into account when prescribing the drug.

Diabetics may develop hypoglycemia during treatment with Fluoxetine, and hyperglycemia after discontinuation of the drug. Taking this into account, it is recommended to make changes to the dosage regimen of insulin and/or oral hypoglycemic agents. Until the clinical picture improves, patients with diabetes mellitus should be under constant medical supervision.

During the treatment period, it is necessary to refrain from engaging in activities that require a high speed of psychomotor reactions and increased attention.

The tablets contain lactose, so they should not be taken if you have galactosemia, lactase deficiency, or glucose/galactose malabsorption syndrome.

Like other antidepressants, fluoxetine can cause mood disorders (mania or hypomania).

The central organ of drug metabolism is the liver; the kidneys are responsible for excreting metabolites. Patients with liver pathologies should be prescribed low or alternative daily doses.

In case of renal failure (with Clcr less than 10 ml/min.) after 2 months of treatment using a dose of 20 mg/day. plasma concentrations of fluoxetine/norfluoxetine are the same as in patients with healthy kidneys.

Depression is associated with an increased risk of suicidal ideation and suicide attempts. The risk remains until complete remission. Clinical experience with the drug shows that the risk of suicide increases, as a rule, in the early stages of recovery.

Patients with mental illness and depressive syndrome should be under constant supervision. In placebo-controlled studies in a group of patients receiving antidepressants, it was found that the risk of suicidal behavior is highest in people under 25 years of age.

Patients who have been switched to a lower/higher dose also require special monitoring.

The use of Fluoxetine is associated with the development of akathisia, the subjective symptoms of which are a constant need to be in motion, as well as the inability to sit or stand. These phenomena are especially pronounced in the first weeks of treatment. For patients who have developed such symptoms, the drug is prescribed in the minimum effective dose.

If discontinued suddenly, approximately 60% of patients develop withdrawal symptoms. The likelihood of their occurrence depends on the dose used, the duration of the course, and the level of dose reduction. It is recommended to reduce the dose by titration over 7-14 days.

There are reports of subcutaneous hemorrhages, such as purpura or ecchymosis, occurring during treatment with the drug. Therefore, for patients taking oral anticoagulants that affect platelet function and increase the likelihood of bleeding, as well as for patients with a history of bleeding, Fluoxetine is prescribed taking into account the possible risks.

Fluoxetine analogs

Which is better: Prozac or Fluoxetine?

The active ingredient in Prozac is fluoxetine. Therefore, when choosing one or another product, the decisive factors are price and subjective feelings. The cost of Fluoxetine is significantly lower than the cost of its analogue.

For children

Not used to treat patients under 18 years of age.

A nineteen-week clinical study showed that in depressed children aged 8-18 years, fluoxetine caused a decrease in height and body weight. The effect of the drug on achieving normal growth in adulthood has not been studied.

However, the possibility of growth retardation during puberty cannot be ruled out.

Fluoxetine and alcohol

Drinking alcohol during treatment with Fluoxetine is contraindicated.

Fluoxetine for weight loss

Fluoxetine is often prescribed for bulimic syndrome, a mental syndrome that is accompanied by a lack of satiety and uncontrolled overeating.

The use of the drug reduces appetite and relieves the constant feeling of hunger.

Thus, we can conclude that Fluoxetine can only get rid of excess weight if the reason for its gain is appetite.

However, the drug is not intended for weight loss; its main purpose is to treat depression. Decreased appetite and weight loss are side effects.

The medicine is quite powerful, and the body often reacts to its use with anaphylactic reactions and systemic disorders involving the lungs, skin, kidneys and liver in the pathological process.

How to take Fluoxetine for weight loss?

At the initial stage, diet pills are taken in a minimal dosage - one once a day. If well tolerated, you can switch to taking two tablets - one is taken in the morning, the second in the evening.

The maximum permissible dose is 4 tablets/day.

The drug begins to act after 4-8 hours; it takes about a week to remove fluoxetine from the body.

Reviews on forums confirm the effectiveness of the product - in 1-3 months people got rid of 5-13 kg without much effort. At the same time, all patients who took Fluoxetine note that it is still not worth drinking it just for the sake of losing weight, like Phenibut or Phenotropil, in the absence of indications.

During pregnancy

The safety of the drug in pregnant women has been poorly studied, and the results of some published epidemiological studies are contradictory. Some randomized and cohort studies have found no increase in the likelihood of congenital anomalies.

A prospective study conducted by ENTIS suggests an increased likelihood of developing congenital anomalies in the structure of large vessels or the heart in children whose mothers took fluoxetine in the 1st trimester of pregnancy, compared with children whose mothers did not receive this drug.

A reliable connection between taking the drug in early pregnancy and the formation of malformations in the fetus could not be established. The specific group of CVS anomalies has also not been defined.

The use of SSRIs in the last weeks of pregnancy contributes to the development of complications in newborns, in particular, an increase in the duration of mechanical ventilation and tube feeding and the duration of hospitalization.

There are references to the development of apnea, respiratory distress syndrome, convulsions, hypoglycemia, lability of body temperature and blood pressure, tremor, hyperreflexia, vomiting, cyanosis, difficulties with adequate nutrition, constant crying, excitability, nervous irritability.

The listed pathological conditions may be a consequence of SSRI withdrawal syndrome or a manifestation of their toxic effects.

Reviews of Fluoxetine

Reviews from patients taking Fluoxetine (APO, Lannacher, Kanon) leave the impression of the effectiveness of this drug for depression, bulimic neuroses and OCD.

The forums also often discuss the possibility of using the drug to control appetite and correct weight.

Reviews from doctors about Fluoxetine for weight loss are clear: the medicine can be used to combat extra pounds only if the cause of weight gain is a mental disorder.

When excess weight is a consequence of overeating caused by depression or stress, the drug allows you to completely get rid of bouts of gluttony in 2-3 weeks and remove up to 5 kg in just the first month.

Reviews of those losing weight about Fluoxetine (Lannacher, OZONE, etc.) allow us to conclude that not everyone succeeds in losing weight on this drug: for some, their appetite disappears completely (even to the point of disgust in food), for others it remains the same.

However, in most cases, the drug has quite serious side effects: many people who took it noted a decrease in libido and a deterioration in sex life, a feeling of lethargy, severe pain, drowsiness, increased aggression, and the appearance of suicidal thoughts.

In addition, for many losing weight, the disadvantages of the drug are the need to stop driving and drinking alcohol, as well as the fact that Fluoxetine is highly addictive.

Summarizing the reviews, we can draw the following conclusions: Fluoxetine is primarily a medicine for depression and can be taken only if indicated and only under the supervision of a doctor.

How much does Fluoxetine cost?

The price in Ukraine for Fluoxetine tablets is from 11 UAH per package No. 10. The price of Fluoxetine in package No. 20 is from 18 UAH.

The price of Fluoxetine in Russian pharmacies depends on which company produced the drug and varies from 27 to 255 rubles. For example, the price of Fluoxetine Lannacher in St. Petersburg is from 112 to 145 rubles per package No. 20, and the price of the drug produced by OZON LLC is rubles.

You can buy Apo-Fluoxetine in Moscow or St. Petersburg for rubles.

The cost of the drug in Belarus is about 120 thousand rubles.

Do I need a prescription for the drug? Undoubtedly it is needed. After all, Fluoxetine is far from a harmless pill. Side effects from uncontrolled use of the drug can be quite serious.

Due to the fact that the drug is not available without a prescription, many are interested in the question of how to buy Fluoxetine online. The attitude towards prescription drugs in online pharmacies is no less strict than in regular ones.

In most cases, when receiving pills, it is enough to show the courier a prescription written by a doctor, but some pharmacies do not deliver prescription drugs, so you need to go in person to pick up the medicine.

• Online pharmacies in Russia Russia
• Online pharmacies in Ukraine Ukraine
• Online pharmacies in Kazakhstan Kazakhstan

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BIOSPHERE

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All materials presented on the site are for reference and informational purposes only and cannot be considered a treatment method prescribed by a doctor or sufficient advice.

We choose fluoxetine analogues depending on the goal

Fluoxetine is a strong antidepressant intended for drug therapy for obsessive and depressive conditions, which are accompanied by anxiety and fear.

Systematic use of this drug helps patients overcome apathy, improve mood, normalize appetite and sleep, and reduce feelings of fear and tension.

First acquaintance with the medicine

The active ingredient of the drug is fluoxetine hydrochloride.

The pharmacological properties of Fluoxetine are based on its ability to inhibit the reuptake of serotonin into the central nervous system, the main neurotransmitter called the hormone of pleasure (or happiness).

It is he who is responsible for a good mood, the absence of tearfulness, pickiness, and boredom. The therapeutic effect of the drug improves the patient’s psycho-emotional activity and does not affect blood pressure, functional activity of the heart, and does not cause drowsiness or lethargy.

The drug is prescribed for:

Pros and cons of the drug

The main advantages of the drug are:

• lack of hypnotic effect and cardiotoxic effect;
• availability in the pharmacy network;
• democratic price.

The disadvantages of the drug include the following side effects:

• dizziness and headache;
• asthenia;
• increased sweating;
• decreased libido;
• the appearance of pain in the bones and mammary glands;
• noise in ears;
• stool instability;
• rashes on the skin;
• dry mouth;
• disturbances of taste and olfactory sensations;
• decreased vision.

• allergic reaction to the main component of the drug;
• pregnancy;
• breastfeeding a baby;
• pathological processes in the liver and kidneys;
• diabetes mellitus;
• epileptic conditions.

This predominance of “cons” over “pros” is a consequence of the fact that this drug is already outdated. Today, the pharmacological industry provides patients with modern analogs of Fluoxetine, which have the ability to selectively affect the human body.

Why are people looking for fluoxetine analogs?

Price issue

Fluoxetine is not the cheapest drug (its price is about 300 rubles) and in order to save money you have to look for more affordable analogues.

Among them are Framex and Flunat - these are more affordable medications that cost from 100 to 150 rubles, and their low price is due to their less famous name.

By-effect

Fluoxetine is a high-quality and proven drug, but it has certain disadvantages, or rather a number of side effects:

• bowel dysfunction;
• infrequent headaches that appear an hour after administration;
• increased heart rate, which can lead to tachycardia;
• overdrying of the mucous membrane;
• blurred vision;
• increased sweat secretions;
• general malaise;
• Women who took the drug experienced pain in the mammary glands and menstrual irregularities (up to several weeks);
• nausea and vomiting;
• noise in ears;
• constant feeling of fatigue;
• sleep disorders;
• depression;
• acne and allergic irritations;
• broken bones;
• sexual apathy (loss of interest in sex).

The list of contraindications is quite long and that is why most people are looking for more harmless analogues. For example, it could be Flunat or Deprex. The drugs have a natural composition and a less aggressive effect on the patient’s body.

No choice

Of course, the last reason why people turn to analogues of this drug is simply its absence on the shelves in pharmacies, since Fluoxetine is a sought-after medication.

If this medicine is not available in the pharmacy, then you should turn your attention to Profluzac and Fluval, which are identical in their action and composition.

Analogues in terms of active substance, composition, action

The active substance fluoxetine hydrochloride has the following analogues:

Similar medications in composition and effects on the body:

• Portal, composition: fluoxetine and vitamin supplements;
• Prodep, composition: fluoxetine and calcium;
• Prozac, composition: fluoxetine and sedatives.

Unlike Fluoxetine, almost all similar drugs contain fewer impurities, which means they are more harmless.

TOP - 15 best analogues

• Apo-Fluoxetine is an antidepressant that has a calming effect and improves mood;
• Bioxetine is a fairly effective selective inhibitor; it is often prescribed for neuroses, since it has practically no side effects;
• Deprex is a product that contains the active substance fluoxetine, which has a sedative and invigorating effect for neuralgia;
• Deprenon is a potent depressant (prescribed for serious mental disorders);
• Portal is an antidepressant in capsule form, which, thanks to its natural composition, has proven itself well as a medicine in the fight against bulimia nervosa;
• Prodep is an antidepressant, a selective serotonin reuptake inhibitor, which improves mood, reduces tension, anxiety and fear;
• Prozac is a natural medicine used for depression (regardless of the degree of depressive disorder - mild, moderate, severe), bulimia, anorexia, alcoholism, obsessive-compulsive disorder;
• Profluzak is a strong antidepressant used in the fight against psychological and nervous conditions;
• Flunate is an adjuvant drug based on fluoxetine, which enhances the effects of Alprazolam, Diazepam and ethanol;
• Fluval is not the most popular, but nevertheless a worthy analogue of Fluoxetine, which is used in conjunction with electroconvulsive therapy;
• Framex is an antidepressant that should only be taken under medical supervision, since when used together with other medications it can increase blood concentration, which can lead to adverse consequences;
• Fluoxetine-Canon is a potent sedative used for violent nervous disorders;
• Floxet is a complete analogue of Fluoxetine, which is used for depression and other disorders;
• Fluoxetine-Lannacher is a selective inhibitor that is used for bulimia nervosa and anorexia;
• Fluoxetine - Nycomed is a sedative based on the parent medication.

A question of price and free access

Cheap analogues of the antidepressant Fluoxetine:

Over-the-counter analogues of Fluoxetine:

This section was created to take care of those who need a qualified specialist, without disturbing the usual rhythm of their own lives.

There are contraindications. Before starting use, consult your doctor.

Commercial names abroad (abroad) - Prozac, Sarafem, Fontex (USA), Zactin, Lovan, Fluohexal, Auscap (Auscapa), Depreks (Turkey), Floxet (Hungary), Flunil, Prodep, Fludac (India), Flutine, Affectine (Israel), Fluox (New Zealand), Fluoxetina (Colombia), Fluzac (Ireland), Fluxen (Ukraine), Fluoxin (Romania), Fontex (Denmark, Norway, Sweden), Ladose (Greece), Philozac (Egypt), Biozac, Deprexetin, Fluval, Biflox, Deprexit, Sofluxen, Floxet, Ranflutin (Bulgaria), Flunisan, Orthon, Refloksetin, Fluoksetin (Macedonia), Seronil (Finland), Lorien (South Africa).

All drugs used in neurology and psychiatry.

You can ask a question or leave a review about the medicine (please, do not forget to indicate the name of the drug in the text of the message).

Preparations containing Fluoxetine (ATC code N06AB03):

Prozac (original Fluoxetine) - official instructions for use. The drug is a prescription, the information is intended only for healthcare professionals!

Clinical and pharmacological group:

Antidepressant.

pharmachologic effect

Antidepressant. It is a selective serotonin reuptake inhibitor, which determines its mechanism of action. Fluoxetine has virtually no affinity for other receptors, for example, α1-, α2- and β-adrenergic receptors, serotonin receptors, dopamine receptors, histamine H1 receptors, m-cholinergic receptors and GABA receptors.

Pharmacokinetics

Suction

After oral administration, it is well absorbed from the gastrointestinal tract. Cmax is reached after 6-8 hours.

Bioavailability when taken orally is more than 60%. Oral dosage forms of fluoxetine are bioequivalent.

Distribution

Binding to blood plasma proteins is more than 90%. Distributed throughout the body. Css in plasma is achieved after taking the drug for several weeks. Css after long-term use of the drug is similar to the concentrations observed at 4-5 weeks of drug use.

Metabolism

Intensively metabolized in the liver to norfluoxetine and a number of other unidentified metabolites.

Removal

Excreted in the urine in the form of metabolites. T1/2 of fluoxetine is 4-6 days, and its main active metabolite is 4-16 days.

Indications for use of PROZAC®

• depression of various etiologies;
• bulimia nervosa;
• obsessive-compulsive disorder;
• premenstrual dysphoric disorder.

Dosage regimen

For obsessive-compulsive disorders, the recommended dose is 20-60 mg per day.

For premenstrual dysphoric disorders, the recommended dose is 20 mg per day.

The drug can be taken regardless of meals.

There is no data on the need to change the dose depending on age.

In patients with impaired liver function, concomitant diseases, or taking other drugs, the dose should be reduced and the frequency of administration should be reduced.

Side effect

From the digestive system: diarrhea, nausea, vomiting, dysphagia, dyspepsia, taste perversion; in isolated cases - idiosyncratic hepatitis.

From the central nervous system and peripheral nervous system: convulsions, ataxia, bucco-glossal syndrome, myoclonus, tremor, anorexia (up to weight loss), anxiety accompanied by palpitations, restlessness, nervousness, agitation, dizziness, fatigue (drowsiness, asthenia), disturbance of the process of concentration and thinking, manic reaction, sleep disturbances (unusual dreams, insomnia); visual impairment (mydriasis, blurred vision); disorders of the autonomic nervous system (dry mouth, increased sweating, vasodilation, chills), serotonin syndrome (a complex of clinical manifestations of changes in mental state and neuromuscular activity in combination with autonomic disorders of the nervous system).

From the genitourinary system: urinary disorders (including frequent urination), priapism/prolonged erection, sexual disorders (decreased libido, delayed or absent ejaculation, lack of orgasm, impotence).

From the endocrine system: disorders of ADH secretion.

Allergic reactions: itching, skin rash, urticaria, anaphylactic reactions, vasculitis, reactions similar to serum sickness.

Dermatological reactions: photosensitivity, alopecia.

Other: yawning, ecchymosis.

Contraindications to the use of PROZAC®

• established hypersensitivity to fluoxetine.

Use of PROZAC® during pregnancy and breastfeeding

Experimental studies on animals did not reveal direct or indirect negative effects of fluoxetine on the development of the embryo or fetus or on the course of pregnancy. There is no evidence of mutagenicity or impairment of fertility from in vitro or animal studies. Because animal reproduction studies do not always predict human response, Prozac should be used during pregnancy only when absolutely necessary.

Fluoxetine is excreted in breast milk, so the drug should be administered with caution to nursing mothers.

The effect of fluoxetine on labor in humans is unknown.

Use for liver dysfunction

In patients with impaired liver function, the dose should be reduced and the frequency of administration should be reduced.

Use in children

The safety and effectiveness of Prozac in children have not been established.

special instructions

There are reports of skin rashes, anaphylactic reactions and progressive systemic disorders involving the skin, lungs, liver, and kidneys in the pathological process in patients taking fluoxetine. If a skin rash or other possible allergic reaction occurs, the etiology of which cannot be determined, Prozac should be discontinued.

As with other antidepressants, Prozac should be used with caution in patients with a history of epileptic seizures.

When using fluoxetine, there have been cases of hyponatremia (in some cases, the level of sodium in the blood was less than 110 mmol/l). Mostly, such cases were observed in elderly patients and in patients receiving diuretics, due to a decrease in blood volume.

In patients with diabetes mellitus, hypoglycemia was observed during treatment with Prozac, and hyperglycemia was observed after discontinuation of the drug. At the beginning and after the end of treatment with fluoxetine, dose adjustments of insulin and/or oral hypoglycemic drugs may be required.

Experimental results

There is no evidence of carcinogenicity from in vitro or animal studies.

Impact on the ability to drive vehicles and operate machinery

Drugs that affect mental functioning may affect decision-making and driving skills. Patients should be advised to avoid driving a car or operating dangerous machinery until it has been established that the drug does not affect the ability to perform these types of activities.

Overdose

Symptoms: nausea, vomiting, seizures, dysfunction of the cardiovascular system (from asymptomatic arrhythmias to cardiac arrest), dysfunction of the respiratory system and signs of changes in the state of the central nervous system from excitation to coma.

Cases of overdose of fluoxetine alone are usually mild, and death has been extremely rare.

Treatment: monitoring of general condition and cardiac activity along with general symptomatic and supportive therapy. A specific antidote is unknown. The effectiveness of forced diuresis, dialysis, hemoperfusion, and cross-transfusion is unlikely.

When treating an overdose, the possibility of using multiple medications should be considered.

Drug interactions

Prozac should not be co-administered with MAO inhibitors and for at least 14 days after stopping treatment with MAO inhibitors. After discontinuation of fluoxetine and initiation of treatment with MAO inhibitors, there should be an interval of at least 5 weeks. If long-term treatment with fluoxetine was carried out and/or the drug was used in high doses, then this interval should be increased. Among patients who had previously taken fluoxetine and started taking MAO inhibitors at a shorter interval, serious cases of serotonin syndrome (manifestations of which may be similar to NMS), including death, have been reported.

Fluoxetine has the ability to inhibit the CYP2D6 isoenzyme. Therefore, treatment with drugs that are metabolized by this system and that have a narrow therapeutic index should be started with the lowest doses if the patient is concurrently receiving fluoxetine or has taken it within the previous 5 weeks. If fluoxetine is included in the treatment regimen of a patient already taking a similar drug, a reduction in the dose of the first drug should be considered.

When used concomitantly with Prozac, changes in blood concentrations of phenytoin, carbamazepine, haloperidol, clozapine, diazepam, alprazolam, lithium, imipramine and desipramine are observed, and in some cases toxic effects were observed. When taking fluoxetine in combination with these drugs, conservative dosage selection should be provided and the patient's condition should be monitored.

Fluoxetine is tightly bound to plasma proteins. Therefore, when prescribing fluoxetine while using another drug that binds tightly to plasma proteins, changes in the plasma concentrations of both drugs are possible.

When fluoxetine was used concomitantly with warfarin, an increase in bleeding time was observed. Changes in anticoagulant action (laboratory values ​​and/or clinical signs and symptoms) were inconsistent. As with warfarin in combination with many other drugs, close monitoring of blood clotting parameters should be performed when fluoxetine is initiated or discontinued during warfarin therapy.

If it is necessary to prescribe other drugs after discontinuation of Prozac, the long half-life of fluoxetine and its active metabolite norfluoxetine and, therefore, the possibility of drug interactions should be taken into account.

There have been rare cases of increased duration of seizures in patients taking fluoxetine during electroconvulsive therapy.

Conditions for dispensing from pharmacies

The drug is available with a prescription.

Storage conditions and periods

The drug should be stored at room temperature (from 15° to 30°C), out of the reach of children.

Release form
Hard gelatin capsules, No. 4, with a white body and a blue cap; the contents of the capsules are white or almost white granules.

Compound
fluoxetine hydrochloride 11.2 mg, which corresponds to the content of fluoxetine 10 mg
Excipients: lactose monohydrate (milk sugar) - 30.8 mg, microcrystalline cellulose - 16.1 mg, colloidal silicon dioxide (aerosil) - 150 mcg, magnesium stearate - 600 mcg, talc - 1.15 mg.
Composition of the capsule shell: gelatin - 36.44 mg, titanium dioxide - 1.52 mg, indigo carmine - 40 mcg.

Package
10 pieces. - contour cell packaging (2) - cardboard packs.

pharmachologic effect
An antidepressant from the group of selective serotonin reuptake inhibitors. It has a thymoanaleptic and stimulating effect.
Selectively blocks the reverse neuronal uptake of serotonin (5HT) at the synapses of neurons in the central nervous system. Inhibition of serotonin reuptake leads to an increase in the concentration of this neurotransmitter in the synaptic cleft, enhancing and prolonging its effect on postsynaptic receptor sites. By increasing serotonergic transmission, fluoxetine inhibits neurotransmitter metabolism through the negative membrane binding mechanism. With long-term use, fluoxetine inhibits the activity of 5-HT1 receptors. Weakly affects the reuptake of norepinephrine and dopamine. It has no direct effect on serotonin, m-cholinergic, H1-histamine and alpha-adrenergic receptors. Unlike most antidepressants, it does not cause a decrease in the activity of postsynaptic beta-adrenergic receptors.
Effective for endogenous depression and obsessive-compulsive disorders. It has an anorexigenic effect and can cause weight loss. Does not cause orthostatic hypotension, sedation, and is noncardiotoxic. A lasting clinical effect occurs after 1-2 weeks of treatment.

Pharmacokinetics
When taken orally, the drug is well absorbed from the gastrointestinal tract (up to 95% of the dose taken); administration with food slightly inhibits the absorption of fluoxetine. Cmax in blood plasma is reached after 6-8 hours. The bioavailability of fluoxetine after oral administration is more than 60%. The drug accumulates well in tissues, easily penetrates the blood-brain barrier, binding to blood plasma proteins is more than 90%. Metabolized in the liver by demethylation to the active metabolite norfluoxetine and a number of unidentified metabolites. It is excreted by the kidneys in the form of metabolites (80%) and the intestines (15%), mainly in the form of glucuronides. T1/2 of fluoxetine after reaching equilibrium concentration in the blood plasma is about 4-6 days. T1/2 of the active metabolite of norfluoxetine with a single dose and after reaching equilibrium concentration in the blood plasma ranges from 4 to 16 days. In patients with liver failure, the half-life of fluoxetine and norfluoxetine is prolonged.

Fluoxetine, indications for use
- depression of various origins;
- obsessive-compulsive disorders;
- bulimic neurosis.

Contraindications
- simultaneous use with MAO inhibitors (and within 14 days after their withdrawal);
- simultaneous use of thioridazine (and for 5 weeks after discontinuation of fluoxetine), pimozide;
- pregnancy;
- period of breastfeeding;
- severe renal dysfunction (creatinine clearance less than 10 ml/min);
- liver failure;
- lactase deficiency, lactose intolerance, glucose-galactose malabsorption;
- age up to 18 years;
- increased sensitivity to the drug.

Carefully
Suicidal risk: with depression, there is a possibility of suicide attempts, which may persist until stable remission occurs. Isolated cases of suicidal thoughts and suicidal behavior have been described during therapy or shortly after its completion, similar to the effects of other drugs with similar pharmacological action (antidepressants). Careful monitoring of patients at risk is necessary. Clinicians should encourage patients to promptly report any distressing thoughts or feelings.
Epileptic seizures: Floxetine should be prescribed with caution to patients who have had epileptic seizures.
Hyponatremia: Cases of hyponatremia have been reported. Mostly, such cases were observed in elderly patients and in patients taking diuretics, due to a decrease in circulating blood volume.
Diabetes mellitus: glycemic control in diabetic patients during treatment with fluoxetine showed hypoglycemia; after discontinuation of the drug, hyperglycemia developed. Doses of insulin and/or oral hypoglycemic agents may need to be adjusted at the start or after treatment with fluoxetine.
Renal/liver failure: Fluoxetine is metabolized by the liver and excreted by the kidneys and gastrointestinal tract. In patients with severe liver dysfunction, it is recommended to prescribe lower doses of fluoxetine, or prescribe the drug every other day. When taking fluoxetine at a dose of 20 mg/day for two months, there were no differences in the concentrations of fluoxetine and norfluoxetine in the blood plasma of healthy individuals with normal renal function and patients with severely impaired renal function (creatinine clearance 10 ml/min) requiring hemodialysis.

Directions for use and doses
The drug is taken orally, at any time, regardless of meals.
Depressive state
The initial dose is 20 mg 1 time / day in the first half of the day, regardless of meals. If necessary, the dose can be increased to 40-60 mg/day, divided into 2-3 doses (by 20 mg/day weekly). The maximum daily dose is 80 mg in 2-3 doses.
The clinical effect develops 1-2 weeks after the start of treatment; in some patients it may be achieved later.
Obsessive-compulsive disorders
The recommended dose is 20-60 mg/day.
Bulimic neurosis
The drug is used in a daily dose of 60 mg, divided into 2-3 doses.
Use of the drug in patients of different ages
There are no data on changes in doses depending on age. Treatment of elderly patients should begin with a dose of 20 mg/day.
Accompanying illnesses
It is recommended to prescribe fluoxetine to patients with impaired liver or kidney function using low doses and lengthening the interval between doses.

Use during pregnancy and breastfeeding
Contraindicated during pregnancy and lactation.

Side effects
When using fluoxetine, as in cases of using drugs from the group of selective serotonin reuptake inhibitors, the following adverse events are noted.
From the cardiovascular system: often (≥ 1% - ≤10%) - atrial flutter, hot flashes; uncommon (≥ 0.1% - ≤1%) - hypotension; rarely (≤ 0.1%) - vasculitis, vasolidation.
From the digestive system: very often (≥ 10%) - diarrhea, nausea; often (≥ 1% - ≤10%) - dry mouth, dyspepsia, vomiting; infrequently (≥ 0.1% - ≤1%) - dysphagia, taste perversion; rarely (≤ 0.1%) - pain along the esophagus.
From the hepatobiliary system: rarely (≤ 0.1%) - idiosyncratic hepatitis.
From the immune system: very rarely (≤ 0.1%) - anaphylactic reactions, serum sickness.
Metabolic and nutritional disorders: often (≥ 1% - ≤10%) - anorexia (including weight loss) of the body.
From the musculoskeletal system: infrequently (≥ 0.1% - ≤1%) - muscle twitching.
From the central nervous system: very often (≥ 10%) - headache; often (≥ 1% - ≤10%) - impaired attention, dizziness, lethargy, drowsiness (including hypersomnolence, sedation), tremor; infrequently (≥ 0.1% - ≤1%) - psychomotor agitation, hyperactivity, ataxia, incoordination, bruxism, dyskinesia, myoclonus; rarely (≤ 0.1%) - bucco-glossal syndrome, seizures, serotonin syndrome.
Mental disorders: very often (≥ 10%) - insomnia (including early morning awakening, initial and moderate insomnia); often (≥ 1% - ≤ 10%) - unusual dreams (including nightmares), nervousness, tension, decreased libido (including lack of libido), euphoria, sleep disorder; infrequently (≥ 0.1% - ≤1%) - depersonalization, hyperthymia, impaired orgasm (including anorgasmia), thinking disorders; rarely (≤ 0.1%) - manic disorders.
From the skin: often (≥ 1% - ≤10%) - hyperhidrosis, itching, polymorphic skin rash, urticaria; uncommon (≥ 0.1% - ≤1%) - ecchymosis, tendency to bruise, alopecia, cold sweat; rarely (≤ 0.1%) - angioedema, photosensitivity reactions.
From the senses: often (≥ 1% - ≤10%) - blurred vision; uncommon (≥ 0.1% - ≤1%) - mydriasis.
From the genitourinary system: often (≥ 1% - ≤10%) - frequent urination (including pollakiuria), ejaculation disorders (including lack of ejaculation, dysfunctional ejaculation, early ejaculation, delayed ejaculation, retrograde ejaculation), erectile dysfunction, gynecological bleeding (including bleeding from the cervix, dysfunctional uterine bleeding, bleeding from the genital tract, menometrorrhagia, menorrhagia, metrorrhagia, polymenorrhea, postmenopausal bleeding, uterine bleeding, vaginal bleeding); uncommon (≥ 0.1% - ≤1%) - dysuria; rarely (≤ 0.1%) - sexual dysfunction, priapism.
Post-marketing messages
On the part of the endocrine system, cases of antidiuretic hormone deficiency have been reported.
These side effects more often occur at the beginning of fluoxetine therapy or when the dose of the drug is increased.

special instructions
Careful monitoring of patients with suicidal tendencies is required, especially at the beginning of treatment. The risk of suicide is highest in patients who have previously taken other antidepressants and in patients who experience excessive fatigue, hypersomnia, or restlessness during treatment with fluoxetine. Until significant improvement in treatment occurs, such patients should be under medical supervision.
In children, adolescents and young adults (under 24 years of age) with depression and other mental disorders, antidepressants, compared with placebo, increase the risk of suicidal thoughts and suicidal behavior. Therefore, when prescribing fluoxetine or any other antidepressants in children, adolescents and young adults (under 24 years of age), the risk of suicide should be weighed against the benefits of their use. In short-term studies, the risk of suicide did not increase in people over 24 years of age, but it decreased slightly in people over 65 years of age. Any depressive disorder itself increases the risk of suicide. Therefore, during treatment with antidepressants, all patients should be monitored for early detection of disturbances or changes in behavior, as well as suicidality.
During electroconvulsive therapy, prolonged epileptic seizures may develop.
The interval between the end of therapy with MAO inhibitors and the start of treatment with fluoxetine should be at least 14 days; between the end of treatment with fluoxetine and the start of therapy with MAO inhibitors - at least 5 weeks.
After discontinuation of the drug, its therapeutic concentration in the blood serum may remain for several weeks.
In patients with diabetes mellitus, hypoglycemia may develop during fluoxetine therapy and hyperglycemia after its discontinuation. Doses of insulin and/or oral hypoglycemic agents may need to be adjusted at the start or after treatment with fluoxetine.
When treating patients with underweight, anorexigenic effects should be taken into account (progressive weight loss is possible).
While taking fluoxetine, you should refrain from drinking alcohol, because. the drug enhances the effect of alcohol.

Impact on the ability to drive vehicles and operate machinery
Taking fluoxetine may negatively affect the performance of work that requires a high speed of mental and physical reactions.

Drug interactions
Fluoxetine and its main metabolite, norfluoxetine, have long half-lives, which must be taken into account when combining fluoxetine with other drugs, as well as when replacing it with another antidepressant.
The drug should not be used simultaneously with MAO inhibitors, incl. antidepressants - MAO inhibitors; furazolidone, procarbazine, selegiline, as well as tryptophan (a precursor of serotonin), since the development of serotonergic syndrome is possible, manifested in confusion, hypomanic state, psychomotor agitation, convulsions, dysarthria, hypertensive crises, chills, tremor, nausea, vomiting, diarrhea.
After using MAO inhibitors, fluoxetine should be prescribed no earlier than 14 days. MAO inhibitors should not be used earlier than 5 weeks after stopping fluoxetine.
Concomitant use of drugs metabolized by the CYP2D6 isoenzyme (carbamazepine, diazepam, propafenone) with fluoxetine should be carried out using minimal therapeutic doses. Fluoxetine blocks the metabolism of the tricyclic and tetracyclic anti-depressive drugs trazodone, metoprolol, terfenadine, which leads to an increase in their concentration in the blood serum, enhancing their effect and increasing the frequency of complications.
In patients stable on maintenance doses of phenytoin, plasma phenytoin concentrations increased significantly and symptoms of phenytoin toxicity (nystagmus, diplopia, ataxia, and CNS depression) appeared after initiation of concomitant treatment with fluoxetine.
The combined use of fluoxetine and lithium salts requires careful monitoring of the concentration of lithium in the blood, because it is possible to increase it.
Fluoxetine enhances the effect of hypoglycemic drugs.
When used simultaneously with drugs that are highly protein bound, especially with anticoagulants and digitoxin, plasma concentrations of free (unbound) drugs may increase and the risk of adverse effects may increase.

Overdose
Symptoms: psychomotor agitation, seizures, drowsiness, heart rhythm disturbances, tachycardia, nausea, vomiting.
Other serious symptoms of fluoxetine overdose (both when fluoxetine was taken alone and when taken concomitantly with other drugs) included coma, delirium, QT prolongation and ventricular tachyarrhythmia, including torsades de pointes and cardiac arrest, decreased blood pressure, syncope, mania, pyrexia, stupor and neuroleptic malignant syndrome-like state
Treatment: specific antagonists to fluoxetine have not been found. Symptomatic therapy is carried out, gastric lavage with the administration of activated charcoal, for convulsions - diazepam, maintenance of breathing, cardiac activity, body temperature.

Storage conditions
In a dry place, protected from light, at a temperature not exceeding 25°C. Keep out of the reach of children.

Best before date
3 years.

It seems to suit me. I finish 1 package, 3 in total. I drink it exclusively according to the doctor’s prescription, I was prescribed 1 tablet once a day. There may have been some side effects in the first 2 days, but now everything is fine. I feel much better. And yes, I managed to lose a couple of kilos.

Advantages It's cheap
Good for prolonged depression
Bouts of gluttony disappeared

Flaws No

I didn’t like that after it men’s potency dropped. my husband drank, then even smarprost didn’t help, he became even more nervous and fell into depression. not enough pleasant things

Antidepressants are a very personal matter. everything is very individual. It's not about whether the pills are good or bad, it's just about whether they're right for your body

I was dealing with a headache, went through all the circles of hell trying to find out what the reason was... The neurologist prescribed me fluoxetine (she said the cause of the headache was prolonged depression). I drank according to the instructions - it was a nightmare! I didn’t live, but existed... I ate, slept , clouded consciousness - somehow I was still working. I was thin to the bone! In general, the headaches did not go away, and I passed such a test! I beg you, don’t drink to lose weight! Let it be an extra one... I was dealing with a headache, went through all the circles of hell trying to find out what the reason was... The neurologist prescribed me fluoxetine (she said the cause of the headache was prolonged depression). I drank according to the instructions - it was a nightmare! I didn’t live, but existed... I ate, slept , clouded consciousness - somehow I was still working. I was thin to the bone! In general, the headaches did not go away, and I passed such a test! I beg you, don’t drink to lose weight! I may be overweight, but healthy!

Excellent, easy drug. You just need to drink correctly. Firstly, it develops its effect after 7-10 days / accumulation dose /, our patients often quit it during this week: “Oh, I’ve been drinking it for 7 days, it doesn’t do anything!” And he only reached the therapeutic maximum. After 10 days they notice that they started yelling... Excellent, easy drug. You just need to drink correctly. Firstly, it develops its effect after 7-10 days / accumulation dose /, our patients often quit it during this week: “Oh, I’ve been drinking it for 7 days, it doesn’t do anything!” And he only reached the therapeutic maximum. After 10 days, they notice that they are yelling less, they don’t get irritated over trifles, they sleep well, things are going well, they start taking care of themselves, they smile, they joke. You need to drink for at least 1.5-2 months, then see a doctor: decide to continue drinking if your mood is still unstable; or SLOWLY cancel in a decreasing pattern.

Fluoxetine helped me. I drank for depression and also lost a lot of weight. It didn’t cause any side effects for me. I felt great, didn’t get irritated over trifles like before.

I took fluoxetine Lannacher to curb my appetite and stop worrying about trifles. Regular flu doesn't help, drinking it will only torment your liver in vain) Now I want to get off it =) I took fluoxetine Lannacher to curb my appetite and stop worrying about trifles.
Regular flu doesn't help, drinking it will only torment your liver in vain)
Now I want to get off it =)

Fluoxetine price is 28 rubles, is that expensive? I’ve been drinking it for two weeks now to lose weight, and I’m very pleased. I don’t feel like eating at all, I’m losing weight before my eyes. Thanks to this drug.

I am very pleased with the preparation. It seems to me that he was the only one who helped my daughter become humanoid. I mean, she is an alcoholic and she drank to such an extent that I thought we had lost her. And now he’s a completely different person, his nerves are back in place, no hysterics. If this drug had been prescribed earlier... I am very pleased with the preparation. It seems to me that he was the only one who helped my daughter become humanoid. I mean, she is an alcoholic and she drank to such an extent that I thought we had lost her. And now he’s a completely different person, his nerves are back in place, no hysterics. If this drug had been prescribed earlier, she might have stopped drinking altogether. Of course, she has breakdowns, but much less often, and she began to sleep like normal people at night. I tell this drug S P A S I B O

Fluoxetine is quite expensive, but for me this is important, and when I took this drug, my condition worsened, chills appeared, wild weakness, I stopped eating altogether. Wild NAUSEA, I had to switch to another drug, Neurofull, it seems to work stably and it can be combined with alcohol ( Sorry for these details but... Fluoxetine is quite expensive, but for me this is important, and when I took this drug, my condition worsened, chills appeared, wild weakness, I stopped eating altogether. Wild NAUSEA, I had to switch to another drug, Neurofull, it seems to work stably and it can be combined with alcohol ( quarrel over such details, but on weekends sometimes you really want it, and holidays, birthdays, alas, you can’t live without it) I of course know that it’s not advisable, but with other pills it’s absolutely not possible.
The doctor prescribed fluoxetine for depression. There was a difficult moment in life. I had to take this drug. But instead of helping, this drug only made my condition worse. Either I was indifferent to everything and everyone, then I became aggressive. At work they have already become afraid of me and avoid communicating with me. There were moments when she seemed to behave normally. But she could break down at any moment and scream and quarrel just because of nothing. In general, just terrible. Now I remember and it seems to me that it was a terrible dream. When I stopped taking Fluoxetine, I was off it for another two weeks. Now I just thank the Almighty that I feel normal. Because the roof wasn't completely blown off. Do not take this drug.