How quickly the body recovers after genitalia. Escapelle or Postinor or Genale - which is better? Zhenale – mechanism of action, how to take for emergency contraception, contraindications and reviews

If during sex contraceptive methods were ineffective or were not used at all, in order to prevent unwanted pregnancy, it is recommended to take Zhenale. This is an emergency contraceptive drug, under the influence of which the endometrium becomes so weak and thin that the fertilized egg cannot attach to the walls of the uterus. The product has many side effects, so it should be used no more than once a month, having first studied the instructions. For the same reason, the drug cannot be included in a routine contraception regimen.

Instructions for use Zhenale

Genale is produced by the Russian pharmaceutical company Izvarino Pharma. The active component of the product is the synthetic steroid mifepristone. This substance is used for:

• medical abortion in the first one and a half months of pregnancy without surgical intervention;
• to prevent conception after unprotected sex or when protective measures were ineffective (the condom burst, the due date for taking contraceptives was missed, etc.)

Composition and release form

Zhenale are yellow-green tablets, which are produced in cardboard packages or jars in quantities of 1 or 2 pieces. One capsule contains 10 mg of mifepristone - the dose necessary to prevent a fertilized egg from implanting in the uterus. Additional components of the steroid drug are:

Pharmacodynamics and pharmacokinetics

In the first phase of the menstrual cycle, mifepristone inhibits the development of the follicle, blocking the effect of the hormone progesterone on the reproductive system through receptors. For this reason, it is considered an antigestagenic agent. The role of progesterone is that it actively participates in preparing the female body for pregnancy, and after conception occurs, it promotes gestation.

Delayed development of the follicle leads to a later onset of ovulation (the release of a mature egg from it), during which conception occurs. This allows you to prevent fertilization according to the calendar date. However, protection should be used during subsequent sex during a given menstrual cycle, as a woman may become pregnant because ovulation occurred later and went unnoticed. For the same reason, the menstrual cycle is disrupted, which is why the next period comes late.

Genale stops the implantation of a fertilized egg by increasing the contractility of the myometrium, the muscular layer of the uterus, and its sensitivity to prostaglandins. The drug stimulates the release of interleukin 8 in choriodecidual cells (formed during pregnancy), which activates the migration of immune cells to the infected site. All this leads to peeling of the decidua (the functional layer of the endometrium that separates the fetus from the myometrium) and the release of a fertilized egg.

The maximum level of mifepristone in the blood is observed one and a half hours after consuming the drug. In the bloodstream, 98% of the active component binds to transport proteins, which carry it to its destination. The removal of the drug from the body is carried out in several stages: at first slowly, then the process accelerates significantly. The half-life of the drug is 17 hours.

Indications for use

The drug Zhenale is designed for emergency contraception after sex, during which contraceptive methods were not used or they were ineffective. It should be noted that the United States and many European countries have banned the sale of drugs based on mifepristone as a means of preventing pregnancy, and are used only for medical abortion under the strict supervision of a physician.

Directions for use and dosage

To prevent pregnancy, you need to take 1 Zhenale tablet 2 hours before or after meals, regardless of the phase of the menstrual cycle, for three days after unprotected sex. The sooner this is done, the greater the chance of preventing conception. If a woman has had sexual intercourse before, before taking the drug, she should do a pregnancy test by donating blood for hCG: if she is already expecting a child, she should not take the drug. One tablet is not enough to cause a miscarriage, and the fetus will be harmed.

special instructions

Zhenale for abortion causes hormonal disruptions and changes in the structure of the myometrium, so it cannot be used as a permanent method of contraception. During the menstrual cycle during which the pill was taken, sex should be had using a barrier method of contraception. This will not only protect you from unwanted pregnancy, but also prevent you from contracting AIDS and other sexually transmitted diseases: pills are powerless against them.

If pregnancy occurs after Zhenale, doctors recommend an abortion, since the drug can cause serious pathologies and disabilities in the fetus. However, there are many cases where women decided to give birth after taking the drug, and the child was born healthy. Laboratory and instrumental studies - blood tests, ultrasound, etc. - will help dispel or confirm fears during pregnancy.

Drug interactions

Genale may reduce the effectiveness of drugs used to treat other diseases. For this reason, after taking Zhenale, it is not recommended to use non-steroidal anti-inflammatory drugs for two weeks. Among them:

• Acetylsalicylic acid, known under the brand name Aspirin;
• Indomethacin;
• Ibuprofen;
• Citramon;
• Indomethacin;
• Methindol;
• Naproxen;
• Butadion;
• Reopirin.

Genale and alcohol

Alcohol reduces the effectiveness of the product. The interval between the last drink of alcohol and Genale should be 3 hours, and the amount of alcohol consumed should not exceed 20 mg of ethanol (50 g of wine, a glass of vodka, half a liter of beer). When taking alcohol and Zhenale simultaneously, the load on the liver and kidneys, which are responsible for processing toxins and removing them out through feces or urine, increases. This combination can lead to disruptions in the gastrointestinal tract, which will manifest itself as diarrhea, vomiting, and nausea.

Side effects of Genale

After taking Zhenale, many women experience severe disruption of their menstrual cycle; the delay can be one to two months. Side effects include bloody discharge from the genital tract, nagging pain in the lower abdomen, dizziness, migraines, and weakness. The drug can cause allergies in the form of rash, itching, hives, etc. Hyperthermia (fever), nausea, diarrhea, exacerbation of chronic inflammation of the uterus and appendages are possible.

Contraindications

Like any other medical drug, Zhenale has contraindications. These include:

• long-term treatment with glucocorticosteroids (the drug is their antagonist);
• porphyria – a disorder of pigment metabolism with an increased content of porphins in the blood;
• liver, kidney or adrenal failure;
• anemia;
• failure;
• pregnancy, lactation;
• allergic reaction to the components of the drug;
• disruption of homeostasis;
• severe form of extragenital pathology.

Terms of sale and storage

Birth control pills Zhenale are sold by prescription. Store the product in a dry, dark place, protected from sunlight, at temperatures up to 25°C. Shelf life – 3 years from the date of manufacture.

Analogs

Zhenale can be replaced by another means of emergency contraception, which contains mifepristone at a dosage of 10 mg, and the main difference will be in the excipients. Such a drug is the Russian Ginepristone, the additional components of which are microcrystalline cellulose, sodium carboxymethyl starch, calcium stearate.

If the dose of mifepristone per tablet exceeds 10 mg, the drug has a different purpose. For example, Ginestril, a tablet of which contains 50 mg of mifepristone, is used to treat uterine fibroids (benign formation). Blocking progesterone receptors helps inhibit tumor growth, reduce the size of the uterus and myomatous nodes.

Preparations based on mifepristone in a dosage of 200 mg are used for medical abortion in the first month and a half of pregnancy and inducing labor in the event of fetal death. The regimen for using the drug is prescribed by the doctor based on individual indicators. To get rid of an unwanted pregnancy, the drug should not be taken at your own peril and risk. Such drugs include:

• Mifepristone (Russia);
• Mifegin (France);
• Mifolian (China);
• Mifepresk (Russia);
• Pencrofton (Russia);
• Miropriston (Russia).

Zhenale or Postinor – which is better?

Birth control pills Zhenale can be replaced with the Hungarian drug Postinor, the active substance of which is levonorgestrel (0.75 mg per tablet). This is a synthetic progestogen hormone that reduces the level of FSH and LH, pituitary hormones, under the influence of which the egg matures, its release from the follicle, and the body prepares for fertilization and pregnancy.

After unprotected sex, Postinor should be taken twice: the first dose within three days, then after twelve hours. In this regard, Zhenale is a more convenient drug, the load on the kidneys and liver is lower. If a woman is undergoing treatment, you should know that the list of drugs not recommended for simultaneous use with Postinor is broader (antibiotics, antiviral drugs, tetracycline, sleeping pills). The advantage of Postinor is that if conception has occurred, it does not affect the pregnancy and does not harm the fetus.

Genale or Escapelle - which is better?

An emergency contraceptive is the Hungarian drug Escapel, the active ingredient of which is levonorgestrel (1.5 mg per tablet). For the product to work, you need to take 1 tablet within 72 hours. The effectiveness of the product is 84% ​​on the first day, 65% on the second day, 45% on the third, while with Zhenale this figure is more stable and remains almost unchanged for three days. If pregnancy occurs after taking Escapel, like Postinor, the child can be saved.

Price

The drug Zhenale is sold in many pharmacies in Moscow and the Moscow region. The price fluctuates around 400 rubles.

Unfortunately, sometimes unforeseen situations happen in our lives that require fairly quick adoption of adequate decisions. These include the high probability of unwanted pregnancy. Today, all women have access to so-called emergency contraceptive methods, which help prevent unwanted conception after unprotected (or insufficiently protected) sexual intercourse. And today we are talking about what is better: Escapelle or Postinor or Genale?

Which is better Postinor or Escapelle?

Both medications are members of the group of emergency contraceptives. Both of them can be used to prevent pregnancy after sexual intercourse has occurred. Such drugs contain the same active ingredient called levonorgestrel. It is essentially a synthetic gestagen (artificially created female sex hormone) with contraceptive properties, expressed gestagenic and antiestrogenic qualities.

When used correctly, levonorgestrel can suppress ovulation and prevent fertilization if sexual intercourse occurs at the preovulation stage, when the highest possible probability of fertilization is observed. In addition, such an active component is capable of causing changes in the qualitative characteristics of the endometrium (the inner layer of the uterus), thereby preventing the fixation of a fertilized egg on it. Levonorgestrel also increases the viscosity of the natural secretion of the uterine cervix, which helps prevent the advancement of sperm. But such a medicine is completely ineffective if implantation has already occurred.

To achieve maximum contraceptive effect, both Escapelle and Postinor must be used as soon as possible (within a maximum of seventy-two hours) after sexual intercourse has occurred. Moreover, the effectiveness of such drugs decreases in proportion to the increase in the time interval between sexual intercourse and their use.

Despite the fact that the drugs in question contain the same active ingredient, their amount is slightly different. Thus, the drug Postinor is a source of 0.75 mg of levonorgestrel, and one Escapel tablet contains 1.5 g of this substance.

Based on these differences in composition, the regimen of drug use also differs. So, the medicine Postinor must be used twice - the first time as soon as possible after sexual intercourse, and the second time twelve hours after taking the first tablet.

The medicine Escapelle is taken once - as quickly as possible after insufficiently protected sexual intercourse has occurred.

Both Postinor and Escapelle are produced in Hungary. Readers of “Popular About Health” can freely purchase both drugs at the pharmacy without presenting a prescription from the attending physician. The average cost of two Postinor tablets is three hundred and forty rubles, and one Escapella tablet is four hundred rubles.

Due to the same composition, Postinor and Escapelle have the same contraindications for use and can cause similar side effects. Both medications can be used only as means of “fire” contraception - as rarely as possible, in exceptional cases.

The only difference between these drugs is that Escapelle must be taken once, and Postinor - twice. In some cases, a single dose may be more convenient. It would be a good idea to discuss the advisability of using such medications with your doctor.

Which is better Genale or Escapelle?

Escapelle and Zhenale are also medications for emergency contraception; they prevent pregnancy after insufficiently protected sexual intercourse. But the composition of such drugs is different. So, Escapel, as we have already found out, is a source of levonorgestrel, and the drug Zhenale contains mifepristone.

If levonorgestrel is an artificially obtained progestogen hormone, then mifepristone is an artificially obtained steroidal antigestagen agent, which is not characterized by gestagenic activity.

The effect of taking Escapel and Zhenale is, in principle, the same - they inhibit ovulation, change the quality indicators of the endometrium and prevent implantation (fixation) of a fertilized egg.

Both Escapelle and Genale are available in tablet form. To achieve a contraceptive effect, it is enough to take only one tablet of the chosen drug in the near future after unprotected sexual intercourse (no later than seventy-two hours).

It is worth noting that the effectiveness of Escapelle decreases over time. On the first day after intercourse it is 98%, on the second – 85%, and on the third – 58%. Zhenale remains equally effective for all 72 hours.

Escapelle, as we have already found out, is produced in Hungary, and Genale is produced in Russia. The cost of Escapelle is about four hundred rubles, and the medicine Zhenale is three hundred thirty to three hundred seventy rubles.

Doctors are confident that Zhenale is the more preferable means for emergency contraception, as it is characterized by high efficiency, affordable price and a reduced likelihood of unwanted reactions (side effects), including uterine bleeding, menstrual irregularities, ectopic pregnancy, etc. .

Thus, Genale will be safer than Escapelle.

The drug "Zhenale" is a synthetic steroidal antiprogestogen drug. Refers to emergency contraception. Dragees are prescribed for oral administration. The action is aimed at preventing unwanted pregnancy after unprotected sexual intercourse.

General description of the drug

"Zhenale" is not a hormonal drug. The basis of the medicine is the substance mifepristone. It is a synthetic steroid with antiglucocorticoid activity. It penetrates the circulatory system, entering into a chemical reaction with hormones. There begins to be an obstacle to the release of eggs into the fallopian tubes.

The use of “Zhenale” in the 2nd phase of menstruation ensures the rejection of the uterine endometrium. If the egg is fertilized, the uterus does not allow the zygote to attach.

The drug is absorbed by the body 90 minutes after administration, complete elimination occurs after 3 days.

Indications for use

Emergency contraception is indicated within 72 hours after unprotected sexual intercourse or in case of improper protection (if a condom breaks, unsuccessful interruption of sexual intercourse, erroneous use of the calendar method). The permissible dosage is 1 tablet containing 10 mg of mifepristone.

When uterine leiomyoma (benign neoplasm) is diagnosed, a dose of 50 mg or higher is prescribed. The required amount is prescribed by the attending physician after diagnosis.

The drug in a dosage of 200 mg can be prescribed for termination of pregnancy in the early stages embryo development, but only after consulting a gynecologist.

special instructions

Repeated use of the drug (several menstrual cycles in a row) is unacceptable. The next time you have sexual intercourse, standard methods of protection (condoms, IUD) should be used.

When purchasing tablets, you need to pay attention to the dosage of mifepristone. Taking medications containing 50 or 200 mg of the main component is carried out under the strict supervision of a doctor. These drugs are intended for medical abortion.

Before using Zhenale, you should make sure that you are not pregnant.

Zhenale is an antigestagenic drug for internal use. Its chemical formula is dominated by the synthetic antiprogestogen steroid mifepristone, which blocks the action of the hormone progesterone at the receptor level, while not having gestagenic activity.

Under the influence of the Zhenale tablet, the fertilized egg is removed, which entails a change in the endometrium, a noticeable inhibition of ovulation and an obstacle to the implantation of a fertilized egg.

The maximum concentration in plasma is noticeable after approximately one hour, and the half-life is 18 hours.

Excipients include lactose monohydrate, potato starch, povidone, sodium carboxymethyl starch and magnesium stearate.

Zhenale is produced in the form of round tablets of yellow color with a green tint.

Among analogues, Postinor is known.

Indications and contraindications for the use of Zhenale

The use of Zhenale is appropriate if emergency contraception is needed after unprotected or unplanned sexual intercourse, but not later than 72 hours.

The list of contraindications is quite comprehensive, so it is better to read the instructions before using the tablets. Thus, taking Zhenale is not indicated for pathologies of the kidneys and liver, porphyria, anemia, adrenal insufficiency, pregnancy, lactation, as well as for long-term therapy with glucocorticosteroids. Restrictions also apply to patients who experience hypersensitivity to the components of this contraceptive.

Side effects and overdose of Zhenale

Side effects after using Zhenale can affect many vital systems. Thus, in the reproductive system, blood discharge from the vagina, discomfort and pain in the lower abdomen, as well as exacerbation of pathological processes in the appendages and uterus are possible. Digestive upset is accompanied by nausea, vomiting and diarrhea, and central nervous system disorders are represented by dizziness and migraine attacks. In addition, in some clinical pictures there are allergic reactions on the skin, in particular, urticaria, itching and swelling.

In cases of Zhenale overdose, adrenal insufficiency may predominate.

Instructions for use Zhenale

The drug is taken orally. One Zhenale tablet orally two hours before or two hours after your usual meal, but no later than 72 hours after sex.

Features of the use of Zhenale tablets

Taking the drug does not depend on the menstrual cycle.

Zhenale does not protect against sexually transmitted diseases and AIDS.

This contraceptive is not a method of permanent contraception, and should be taken only in emergency cases. Do not take monthly or several times during one menstrual cycle.

In the future, choose a more reliable means of contraception for regular use.

If Zhenale tablets are ineffective and pregnancy occurs, it must be terminated surgically or medically. If you want to continue the pregnancy, the risk of pathological development of the fetus increases, and the child will be born with serious pathologies.

Zhenale's influence on driving vehicles and other mechanisms is not observed.

Store in a cool place and use as directed.

Drug interactions. Do not use NSAIDs for 8-12 days after taking Zhenale, but otherwise there are no restrictions.

Reviews about the drug Zhenale, price

Of course, many patients prefer the decades-tested medical drug Postinor as emergency contraception, but the popularity of Zhenale is also growing every day.

The fact that Zhenale contains only one tablet, which protects against pregnancy, is captivating, while taking Postinor includes two pills, which should be taken according to a certain scheme. There is only one conclusion: Zhenale is easy to use.

Reviews about Zhenal are extremely positive, since the drug is a real lifesaver after thoughtless sexual intercourse. It gives a 99% guarantee that pregnancy will not occur in the future.

There are no negative reviews regarding the uselessness of Zhenale. It is extremely rare to find notes about the detection of side effects that are limited exclusively to nausea and dizziness.

The use of Zhenale does not require consultation with a specialist, but it still does not hurt to read the instructions carefully before taking it. The drug is truly highly effective, so many women use it with confidence.

Price for Zhenale 10 mg tablet x1 - 305 rubles

01:31 Zhenale: instructions, application, reviews -

Unprotected sexual intercourse often leads to an extremely unwanted pregnancy, which is not included in the plans of many women. That is why many ladies know firsthand about Zhenale tablets, which provide emergency contraception. General description of Zhenale tablets Zhenale is an antigestagenic drug for internal use. Its chemical formula is dominated by the steroidal antiprogestagen agent of synthetic origin mifepristone, which blocks the [...]

Our life is full of surprises and surprises that need to be responded to in a timely manner. One of these troubles that can happen to each of us is unprotected sexual intercourse, which frightens us with a possible pregnancy. This situation may arise due to a broken condom, or for some other reason, but no one is immune from it. That is why every girl needs to know about the possibilities of emergency contraception. Various medications can be used for this purpose. But at the same time, it is worth knowing in advance whether emergency contraception has consequences for the woman’s body and what they are. We will also talk about this today.

Unfortunately, in our country women have a much greater understanding of the rules and regulations of contraception and rarely hope for chance. After all, an unwanted pregnancy often becomes a problem only for the partner, and an abortion is a serious blow to her physical and psychological health. However, routine contraception is not always used. Emergency measures should be taken in the following cases:

In case of insufficiently protected sexual intercourse, if methods of protection were not used at all;
- if the barrier method of contraception is defective (condom breakage);
- improper use of hormonal drugs (torn off patch, missed pill);
- rape.

Types of emergency contraception

Combined drugs with an estrogen-progestin composition (combined contraceptives for oral consumption according to a special scheme);
- gestagens (levonorgestrel, medications Escapelle, Postinor, etc.);
- antiprogestins (for example, mifepristone);
- intrauterine devices (spirals).

All means of emergency contraception can be aimed either at inhibiting the ovulation process, thereby preventing fertilization, or at preventing the fertilized egg from fixing in the uterine cavity. In addition, after consuming certain medicinal compounds, the viscosity of the mucus in the uterine cervix noticeably increases, leading to a decrease in the activity and motility of sperm.

Emergency contraception Escapelle

This is a drug that contains a large dosage of a hormone such as levongestrel. This substance prevents the implantation of the egg in the uterine cavity. One Escapelle tablet contains one hundred and fifty milligrams of the active substance. To achieve a contraceptive effect, you must take one tablet within seventy-two hours after sexual intercourse. It should be taken into account that the maximum effectiveness of the drug is observed if it was used on the first day after unprotected intimate intercourse.

If pregnancy does occur, it is necessary to conduct an ultrasound examination to determine the location of the fetus. If the fertilized egg is in the uterine cavity, it can be preserved. Using Escapelle will not affect his development in any way.

Consequences

In some cases, the drug causes some side effects, namely vomiting or nausea. If an attack of vomiting occurs in the first three hours after consuming the medicine, you need to take another tablet.

Consumption of Escapel can lead to disruptions in the menstrual cycle, causing bleeding, delayed menstruation and pain in the chest area.

If your period is delayed by five days or more, it is worth taking a pregnancy test. You can also donate blood to check the level of the hCG hormone even earlier. Consumption of Escapelle does not in any way affect the results of these studies.

Emergency contraception Genale

This drug, unlike Escapel, does not contain hormones. It is used, conveniently, at any time during the menstrual cycle and can slow down ovulation or prevent the implantation of an already fertilized egg. As in the case of Escapelle, it is enough to take only one tablet to achieve a contraceptive effect, and the dose must be taken within seventy-two hours after unprotected intimate intercourse.

Zhenale is able to suppress ovulation for four days or even more; accordingly, before it occurs, all sperm that enter the genital tract will simply die. Unlike Escapelle, the effectiveness of this product does not depend at all on body weight. Experts say that drugs containing levonorgestrel are much less effective if a woman is overweight or obese.

Zhenale works in 99% of cases, but it can only be used for emergency contraception, and not as a permanent method of protection.

Consequences

Consumption of Zhenale can cause side effects such as vomiting and nausea, headache, and discomfort in the lower abdomen. The girl may also experience dizziness, some weakness, and diarrhea. Possible side effects also include hives and spotting.

In the event that pregnancy does occur, with normal localization of the fertilized egg, it can be preserved, since the drug is not capable of in any way harming the normal development of the fetus.

It is worth considering that any drugs used for emergency contraception cannot be used continuously. This is dangerous for the body and can greatly disrupt the normal functioning of the reproductive system. The use of such drugs is justified only in exceptional cases. If the side effects caused by consuming Escapel or Zhenale do not go away, be sure to consult a doctor.