Lipoic acid for weight loss: detailed instructions for use, reviews. Lipoic acid. Benefits and harms for the body. Instructions for use, how to take for weight loss. Reviews

Alpha lipoic acid, also known as thioctic acid, was first isolated from bovine liver in 1950. According to its chemical structure, it is a fatty acid containing sulfur. It can be found inside every cell in our body, where it helps produce energy. Alpha lipoic acid is a key part of the metabolic process that converts glucose into energy for the body's needs. Thioctic acid is also an antioxidant—it neutralizes harmful chemicals known as free radicals.

Given its significant role in biochemical processes, alpha lipoic acid was originally included in the B complex vitamins. However, it is not currently considered a vitamin. It is supposed to be the most powerful antioxidant available as a supplement.

The cardiovascular benefits of taking alpha lipoic acid are comparable to those of fish oil. Cardiologists in the West, who previously took vitamin E themselves as an antioxidant and for the prevention of cardiovascular diseases, are now switching en masse to thioctic acid.

In what doses is this drug taken?

To prevent and treat complications of type 1 or 2 diabetes, alpha lipoic acid is sometimes prescribed in tablets or capsules at a dosage of 100-200 mg three times a day. Dosages of 600 mg are more common, and such drugs need to be taken only once a day, which is much more convenient. If you choose modern R-lipoic acid supplements, they should be taken in smaller doses - 100 mg 1-2 times a day. This applies in particular to drugs that contain Bio-Enhanced® R-Lipoic Acid from GeroNova. Read more about them below

Food intake has been reported to decrease the bioavailability of alpha lipoic acid. Thus, it is best to take this supplement on an empty stomach, 1 hour before or 2 hours after meals.

If you want to receive thioctic acid intravenously to treat diabetic neuropathy, your doctor will prescribe the dosage. For general prevention, alpha-lipoic acid is usually taken as part of a multivitamin complex, at a dosage of 20-50 mg per day. To date, there is no official evidence that taking this antioxidant in this way provides any health benefits.

Why are antioxidants needed?

Disease and aging are believed to be caused at least in part by free radicals, which are created as byproducts of oxidation (“combustion”) reactions in the body. Because alpha lipoic acid is both water and fat soluble, it acts as an antioxidant at various stages of metabolism and can potentially protect cells from free radical damage. Unlike other antioxidants, which are only water or fat soluble, alpha lipoic acid functions in both water and fat. This is its unique property. In comparison, vitamin E only works in fats, and vitamin C only works in water. Thioctic acid has a universal, wide spectrum of protective action.

Antioxidants are like kamikaze pilots. They sacrifice themselves to neutralize free radicals. One of the most interesting properties of alpha lipoic acid is that it helps restore other antioxidants after they have been used for their intended purpose. In addition, it can do the work of other antioxidants if the body is deficient in them.

Alpha lipoic acid is an ideal antioxidant

An ideal therapeutic antioxidant must meet a number of criteria. These criteria include:

1. Absorption from food.
2. Conversion in cells and tissues into a usable form.
3. A variety of protective functions, including interaction with other antioxidants in cell membranes and intercellular space.
4. Low toxicity.

Alpha Lipoic Acid is unique among natural antioxidants because it fulfills all of these requirements. This makes it a potentially very effective therapeutic agent for treating health problems that are caused by oxidative damage.

Thioctic acid performs the following protective functions:

• Directly neutralizes dangerous reactive oxygen species (free radicals).
• Restores endogenous antioxidants such as glutathione, vitamins E and C for reuse.
• Binds (chelates) toxic metals in the body, which leads to a decrease in the production of free radicals.

This substance plays an important role in maintaining antioxidant synergy, a system called the antioxidant defense network. Thioctic acid directly restores vitamin C, glutathione and coenzyme Q10, allowing them to participate longer in the body's metabolism. It also indirectly restores vitamin E. In addition, it is reported to increase glutathione synthesis in geriatric animals. This occurs because the cellular uptake of cysteine, an amino acid necessary for the synthesis of glutathione, increases. However, it has not yet been proven whether alpha lipoic acid actually plays a significant role in controlling redox processes in cells.

Role in the human body

In the human body, alpha-lipoic acid (actually, only its R-form, read more below) is synthesized in the liver and other tissues, and also comes from animal and plant foods. R-lipoic acid is found in foods in a form bound to the amino acid lysine in proteins. High concentrations of this antioxidant are found in animal tissues where metabolic activity is greatest. These are the heart, liver and kidneys. The main plant sources are spinach, broccoli, tomatoes, garden peas, Brussels sprouts, and rice bran.

Unlike R-lipoic acid, which is found in food products, medical alpha-lipoic acid in preparations is contained in free form, i.e. it is not bound to proteins. Additionally, the doses that are available in tablets and intravenous injections (200-600 mg) are 1000 times higher than what people get from their diet. In Germany, thioctic acid is an officially approved treatment for diabetic neuropathy and is available as a prescription drug. In the USA and Russian-speaking countries, you can buy it at a pharmacy as prescribed by a doctor or as a dietary supplement.

Traditional Alpha Lipoic Acid vs. R-ALA

Alpha lipoic acid exists in two molecular forms - right (R) and left (called L, sometimes also written S). Since the 1980s, medications and dietary supplements have been a 50/50 mixture of these two forms. Then scientists discovered that only the right (R) form is active. In the human body and other animals, only this form is produced and used under natural conditions. It is designated as R-lipoic acid, in English R-ALA.

There are still many bottles of regular alpha lipoic acid sold, which is a mixture of “right” and “left”, equal parts of each. But it is gradually being forced out of the market by supplements that contain only the “right” side. He takes R-ALA himself and prescribes only it to his patients. Customer reviews in English-language online stores confirm that R-lipoic acid is indeed more effective. Following Dr. Bernstein, we recommend choosing R-ALA over traditional alpha lipoic acid.

R-lipoic acid (R-ALA) is a variant of the alpha lipoic acid molecule that is naturally synthesized and used by plants and animals. L-lipoic acid is artificial, synthetic. Traditional alpha lipoic acid supplements are a 50/50 mix of L and R varieties. Newer supplements contain only R-lipoic acid and are labeled R-ALA or R-LA.

Unfortunately, direct comparisons of the effectiveness of mixed variants with R-ALA have not yet been conducted and published. After taking “mixed” tablets, the peak plasma concentration of R-lipoic acid is 40-50% higher than the L-form. This suggests that R-lipoic acid is better absorbed than L-lipoic acid. However, both of these forms of thioctic acid are processed and eliminated from the body too quickly. Almost all published studies on the effects of alpha lipoic acid on the human body were conducted before 2008 and used only mixed supplements.

Reviews from customers, including diabetics, confirm that R-Lipoic Acid (R-ALA) is more effective than traditional mixed alpha lipoic acid. But this has not yet been officially proven. R-lipoic acid is the natural form - it is what the body produces and uses. R-Lipoic Acid is significantly more powerful than regular thioctic acid because the body “recognizes” it and immediately knows how to use it. Manufacturers claim that the human body has difficulty absorbing the unnatural L-version, and it may even actually interfere with the effective action of natural R-lipoic acid.

In recent years, the leadership in the English-speaking world has been taken by GeroNova, which produces “stabilized” R-lipoic acid. It is designated as Bio-Enhanced® R-Lipoic Acid, i.e. improved compared to regular R-ALA. Supplements you can order to treat diabetic neuropathy use its sodium salt, called BioEnhanced® Na-RALA. It went through a unique stabilization process, which GeroNova even patented. Thanks to this, the absorption of Bio-Enhanced® R-lipoic acid has increased by 40 times.

During the stabilization process, toxic metals and residual solvents are also completely removed from the raw material. Bio-Enhanced® R-Lipoic Acid from GeroNova is the highest quality alpha lipoic acid. It is assumed that taking this supplement in capsules has an effect no worse than intravenous administration of thioctic acid using droppers.

GeroNova is a manufacturer of “raw” alpha lipoic acid. And other companies package and sell it to the end consumer: Doctor’s Best, Life Extension, Jarrow Formulas and others. The GeroNova website says that most people, after just two weeks of taking it, notice increased alertness and improved clarity of thinking. However, it is recommended that you take R-Lipoic Acid for two months before deciding how beneficial this supplement has been for you.

Typically, people are able to synthesize enough alpha lipoic acid to meet their body's needs. However, the synthesis of this substance decreases with age and in people with health conditions, including diabetes and its complications such as neuropathy. In these cases, it may be advisable to obtain additional thioctic acid from external sources such as dietary supplement capsules or intravenous injections.

Diabetes treatment: details

Alpha lipoic acid has beneficial effects in many disease conditions - diabetes, multiple sclerosis, cognitive decline and dementia. Since we have a site about the treatment of diabetes, below we will analyze how effective thioctic acid is for type 1 and type 2 diabetes, for the prevention and treatment of complications. Let's immediately note that this antioxidant has the potential to treat many of the health problems that diabetes causes. Recall that in type 1 diabetes, insulin secretion is significantly reduced due to the destruction of beta cells. In type 2 diabetes, the main problem is not insulin deficiency, but resistance of peripheral tissues to it.

It has been proven that complications of diabetes mellitus are largely caused by tissue damage due to oxidative stress. This may be due to increased free radical production or decreased antioxidant defenses. There is compelling evidence that oxidative stress plays an important role in the development of diabetes complications. Elevated blood sugar levels lead to increased concentrations of dangerous reactive oxygen species. Oxidative stress not only causes diabetes complications, but it may also be associated with insulin resistance. Alpha lipoic acid may have preventive and therapeutic effects on various aspects of type 1 and type 2 diabetes.

Type 1 diabetes was artificially induced in laboratory mice using the drug cyclophosphamide. At the same time, they were administered alpha-lipoic acid at a dose of 10 mg per 1 kg of body weight for 10 days. It turned out that the number of mice that developed diabetes decreased by 50%. Scientists also found that this drug increases the utilization of glucose in the tissues of rats - the diaphragm, heart and muscles.

Many of the complications caused by diabetes, including neuropathy and cataracts, appear to result from increased production of reactive oxygen species in the body. In addition, it has been suggested that oxidative stress may be an early event in the pathology of diabetes mellitus and later influence the onset and progression of complications. A study of 107 patients with type 1 and type 2 diabetes showed that those who took alpha-lipoic acid 600 mg per day for 3 months had reduced oxidative stress, compared with those diabetics who were not prescribed the antioxidant. This result occurred even if blood sugar control remained poor and urinary protein excretion was high.

Increased insulin sensitivity

The binding of insulin to its receptors, which are located on the surface of cell membranes, causes the movement of glucose transporters (GLUT-4) from the inside to the cell membrane and increased cellular uptake of glucose from the bloodstream. Alpha lipoic acid was found to activate GLUT-4 and increase glucose uptake by fat and muscle cells. It turns out that it has the same effect as insulin, although many times weaker. Skeletal muscles are the main absorber of glucose. Thioctic acid increases glucose uptake by skeletal muscles. It is potentially useful in the long-term treatment of type 2 diabetes.

However, studies have shown that, unlike intravenous administration, there is only minimal improvement in tissue sensitivity to insulin after oral administration of tablets (<20%). Значительного повышения чувствительности к инсулину не удалось достигнуть даже при назначении высоких доз, до 1800 мг в сутки, и при более длительном времени лечения, 30 дней приема таблеток против 10 дней внутривенного введения. Напомним, что все это — данные старых исследований 1990-х годов, когда еще не было добавок R-липоевой кислоты и тем более патентованной Bio-Enhanced® R-Lipoic Acid фирмы GeroNova. Новые формы альфа-липоевой кислоты в капсулах и таблетках дают эффект, сравнимый с тем, который можно получить от внутривенных уколов.

Diabetic neuropathy

In type 1 and type 2 diabetes, neuropathy occurs because blood flow is disrupted and the conduction of nerve impulses deteriorates. Experimental animal studies have found that treatment with alpha lipoic acid improves both blood flow and nerve conduction. These positive results encouraged scientists to conduct clinical trials on diabetic people. Thioctic acid was first used to treat diabetic neuropathy in Germany more than 30 years ago. It was approved as a drug, despite the fact that at that time there was still not enough information about the causes of diabetes complications. This drug was thought to increase glucose utilization in peripheral nerves.

With diabetic neuropathy, the patient experiences numbness, pain and other unpleasant symptoms. It is assumed that oxidative stress and free radicals play a major role in the development of this complication. If so, then the disease needs to be treated with antioxidants. As we described above in the article, alpha lipoic acid is a powerful antioxidant. However, convincing evidence of its effectiveness was obtained only from studies in which the drug was administered intravenously to diabetics, rather than in oral tablets.

The main studies were carried out before 2007. Later, next-generation supplements began to appear on the market that contain only R-lipoic acid, the active isomer of alpha-lipoic acid. Such supplements do not contain useless L-lipoic acid, whereas traditional preparations consist of R- and L-forms of 50% each. Modern alpha-lipoic acid tablets and capsules are supposed to be very effective, comparable to intravenous drips, and at the same time avoid injections. However, this assumption is based only on statements from manufacturers, as well as numerous reviews from customers in English-language online stores. No formal studies of new R-lipoic acid preparations have yet been conducted.

Diabetes also damages other nerves in the body, namely the autonomic nerves that control internal organs. If this occurs in the heart, cardiac autonomic neuropathy develops, which leads to abnormal heart rhythms. Autonomic neuropathy is a dangerous complication of diabetes, with a high risk of sudden death. There is some evidence that alpha lipoic acid supplements may be beneficial in slowing the progression and treating this disease.

Preliminary and conflicting research evidence suggests that taking alpha lipoic acid may improve not only neuropathy but also other aspects of diabetes. Thioctic acid slightly improves blood sugar control and helps slow down the development of long-term vascular complications such as diseases of the heart, kidneys and small blood vessels. We remind you that the main means of preventing and treating complications of type 1 and type 2 diabetes is. Use supplements only to complement it.

Several clinical trials were conducted between 1995 and 2006 to evaluate the effectiveness of alpha lipoic acid for the treatment of diabetic neuropathy.

These were all double-blind, placebo-controlled studies, i.e. conducted to the highest standards. Unfortunately, scientists have not found any evidence that taking the pills improves blood sugar control in diabetes in any way. However, it has been proven that the utilization of glucose by cells does increase. Thus, despite some differences of opinion among scientists, there is compelling clinical evidence that alpha lipoic acid improves diabetic neuropathy. The effect is especially good if administered intravenously, and even in high doses and for a long time.

Modern R-lipoic acid supplements, including Bio-Enhanced® R-Lipoic Acid from GeroNova, began to appear after 2008. They did not participate in the studies we mentioned above. They are supposed to work much better than the previous generation of alpha-lipoic acid preparations, which are a mixture of R- and L-(S-) isomers. It is even possible that taking these drugs will have an effect comparable to that given by intravenous injections. Unfortunately, at the time of writing this article (July 2014), more recent formal clinical studies are not yet available.

If you are considering IV alpha lipoic acid injections, try taking GeroNova's Bio-Enhanced® R-Lipoic Acid capsules from Doctor's Best, Life Extension, or Jarrow Formulas extended-release tablets first instead.

Perhaps it will work so well that droppers will not be needed. At the same time, we remind you that the main treatment for diabetes is. Diabetic neuropathy is a completely reversible complication. If you normalize your blood sugar with a low-carbohydrate diet, then all its symptoms will go away in a period of several months to 3 years. Perhaps taking alpha lipoic acid will help speed this up. But no pills or injections will really work as long as your diet is overloaded with harmful carbohydrates.

Side effects

Treatment with alpha lipoic acid is generally well tolerated and serious side effects are rare. Theoretically, nausea or indigestion, as well as overexcitement, fatigue or insomnia, may occur, but in practice the likelihood of this tends to zero. High doses of the drug may potentially lower blood sugar. This is usually beneficial for diabetic patients, but requires careful monitoring of glucose levels. The risk of hypoglycemia increases if a diabetic has previously started taking sulfonylurea tablets or insulin injections and now adds alpha-lipoic acid to this.

600 mg per day is a safe and recommended dose for treating diabetes. At higher doses, patients occasionally experience gastrointestinal symptoms: abdominal pain, nausea, vomiting, as well as diarrhea and anaphylactic reactions, including laryngospasm. In addition, allergic reactions, including rash, hives and itchy skin, have been reported. People taking thioctic acid tablets at a dosage of 1200 mg per day may experience foul-smelling urine.

Taking alpha lipoic acid in tablets or droppers depletes the body's biotin reserves. Biotin is one of the water-soluble B vitamins. It is part of enzymes that regulate the metabolism of proteins and fats. Along with alpha lipoic acid, it is also recommended to take biotin in an amount of 1%. Please note that the modern R-lipoic acid supplements we recommend also contain biotin.

The main problem is the relatively high cost of this method of treating diabetes. A daily dose will cost you at least $0.3. And no one can guarantee in advance that you will get significant results for the money. Let us remind you once again that the main way to treat diabetic neuropathy and other complications of type 1 and type 2 diabetes is free, satisfying and tasty. Alpha lipoic acid only complements it. It is supposed to speed up your relief from neuropathy symptoms. If a diabetic's diet remains overloaded with carbohydrates, then taking supplements is money down the drain.

Tablets or droppers - which is better?

Why does traditional “mixed” alpha lipoic acid have little effect when taken in tablets or capsules? It slightly increases the sensitivity of cells to insulin and has virtually no effect on blood sugar levels. Why is this happening? One possible explanation may be that the high therapeutic concentration of the drug in the blood is maintained for a very short time. Thioctic acid has a short half-life in the body, about 30 minutes. Its maximum concentration in the blood is observed 30-60 minutes after oral administration. It is quickly absorbed into the blood, but then just as quickly processed and excreted from the body.

After a single dose of 200 mg, the bioavailability of the drug is about 30%. Even after many days of continuous use of tablets, accumulation of the active substance in the blood does not occur. Its maximum plasma concentration is quickly reached, but then falls just as quickly, to a level insufficient to affect cellular insulin sensitivity or glucose control. Why does thioctic acid work better when administered intravenously than in tablets? Perhaps because the dose of the drug does not enter the body immediately, but gradually, over 30-40 minutes, while the person lies under a drip.

Should you buy alpha lipoic acid at the pharmacy?

In Russian-speaking countries, there are several tens of thousands of people who suffer from diabetic neuropathy. They all desperately want relief from their symptoms, and preferably even a complete recovery. Alpha lipoic acid (also known as thioctic acid) is the only treatment that can be used for neuropathy in addition to general diabetes management methods. It is not surprising that its drugs are in great demand among patients, despite their high price.

Common alpha lipoic acid preparations sold in pharmacies:

• Berlition;
• Lipamide;
• Lipothioxone;
• Neurolipon;
• Octolipen;
• Thiogamma;
• Thioctacid;
• Thiolepta;
• Thiolipon;
• Espa-Lipon.

Manufacturers actively advertise these tablets and intravenous solutions to both diabetic patients and physicians. However, we recommend that you do not buy alpha lipoic acid at the pharmacy, but order it online from the USA (read). This way you will get real value for your money. Diabetics who are treated periodically with alpha lipoic acid drips can instead switch to modern, effective capsules and tablets. Obviously, this is much more convenient, and even cheaper.

Thioctic acid preparations, which consist in half of the R- and L-form, are still widely used. Only they are sold in pharmacies in Russian-speaking countries. However, in the West they are gradually being replaced by supplements that contain only R-lipoic acid. Reviews from Russian-speaking diabetic patients indicate that taking alpha-lipoic acid tablets is useless, and only its intravenous administration really helps. At the same time, in civilized countries, diabetics take modern R-lipoic acid supplements and confirm their significant benefits. Slow-release alpha-lipoic acid tablets are also helpful because they allow you to maintain a high concentration of the drug in the blood for a long time.

American alpha-lipoic acid supplements of the latest generation are a real alternative to IVs, which are now used to treat many Russian-speaking diabetic patients. However, we remind you that a truly effective treatment for diabetic neuropathy and other complications is. Any pills play a secondary role compared to a proper diet. Normalize your sugar with a low-carbohydrate diet - and all the symptoms of neuropathy will gradually disappear. It is suggested that alpha lipoic acid may speed up this process, but it is not a diet replacement.

How to order alpha lipoic acid from the USA on iHerb- or . Instructions in Russian.

So, we've figured out why American alpha lipoic acid supplements are more effective and convenient than the drugs you can buy at the pharmacy. Now let's compare prices.

Treatment with high-quality American alpha-lipoic acid preparations will cost you $0.3-$0.6 per day, depending on the dosage. Obviously, this is cheaper than buying thioctic acid tablets at the pharmacy, and with droppers the price difference is generally cosmic. Ordering supplements from the US online can be more hassle than going to the pharmacy, especially for older adults. But it will pay off because you'll get real value for less.

Lipoic acid, instructions for use of the medication, the possibility of its use as a prophylactic agent, and rules of administration are increasingly of interest to people exposed to intense informational and emotional stress or engaged in physical labor. They are forced to protect their body cells from premature wear and tear, and they want to do this with the most natural compounds possible. Can the described medication help them with this?

Alpha lipoic acid is one of those rare medications that are equally successfully used for therapeutic purposes, preventive, as a means to give a slim figure, and to stimulate body sculpting processes, in combination with Alpha-carnitine.

Let's talk about this many-sided tool in more detail. Let’s pay attention not only to the medical purpose of the drug, but also to what is good about lipoic acid for weight loss, reviews of how to take the product, and how effective it is.

General characteristics of the drug

Thioctic (α-lipoic) acid is the active component of the tablet drug, and provides the therapeutic and lipolytic effect of the drug.

The instructions classify lipoic acid in the category of “other drugs” used to treat diseases of the gastrointestinal tract and metabolic changes. This formulation most often raises the question: What is lipoic acid needed for?

Thioctic acid is produced by the human body as a regulator of fat-carbohydrate metabolism and activates fat utilization processes. It plays a protective role in relation to cells, primarily liver cells, protecting them from the effects of heavy metals and free radicals. The effects of thioctic acid are similar to. Accordingly, it is able to influence the nervous system (increases the nutrition of neurons), in addition, the compound takes part in metabolic processes occurring in the mitochondria of cells. Enhances the utilization of blood sugar (glucose) and increases glycogen reserves in the liver, affects cholesterol metabolism. A detoxification effect has been observed from the use of the drug to reduce the harmful effects of toxic substances on the body. If there is a lack of endogenous thioctic acid, it must be replenished from the outside.

The drug is available in tablets and solution for injection. In severe cases, it can even be administered intravenously (stream).

Based on the effect that thioctic acid has, it is easy to understand what ailments it can help with. And since not only illness can be the reason for taking this remedy, the list of situations in which its use is effective is quite wide.

Indications for use

1. Poisoning.
2. Liver pathology.
3. Some nervous diseases.

This medicine provides invaluable support to the body in case of poisoning with toadstool and fly agaric, salts of heavy metals and sleeping pills.

As a maintenance therapy, thioctic acid can be prescribed for liver cirrhosis, liver failure even in acute form, chronic and viral hepatitis, and fatty liver. And also for pancreatitis, including alcoholic, and with concomitant damage to the gallbladder. The drug has proven itself well in the treatment of polyneuropathy, primarily diabetic and alcoholic polyneuropathy. The medication can be prescribed for the treatment of diabetes, to alleviate the course of cancer. And as a means that can reduce the “withdrawal effect” of hormonal treatment.

Preventive measures and effectiveness in weight loss

Since lipoic acid has metabolic properties, it can be taken as a metabolic support. Often this property of the drug, as well as its ability to increase muscle endurance, is used by athletes taking it in combination with Levocarnitine, primarily bodybuilders.

If men with bulky muscles need this compound, then why do women need Lipoic acid? The answer is simple: to maintain a slim figure. This becomes possible thanks to three qualities of the drug:

• ability to burn fat;
• normalize fat and carbohydrate metabolism;
• reduce appetite.

It is actively used by those who want to bring their figure into ideal condition. Of course, Lipoic acid is not a “miracle pill” for lazy people. Those who do not want to tax their body with fitness or other physical efforts will not be able to reduce their weight by taking only this remedy. The active substance of the drug only activates lipolytic processes, but cannot cope with its accumulation on its own. The instructions for use recommend combining the use of lipoic acid for weight loss with bringing your diet to a healthy and nutritious level, and moderate physical activity.

Contraindications and side effects of the drug

You need to take the drug as prescribed by your doctor. In case of individual intolerance to its components, the use of this product is prohibited. It is not used during pregnancy and lactation. This remedy is also not recommended for children under 16 years of age.

It is better not to exceed the dosage prescribed by the doctor, as you can overdose on the drug and experience such unpleasant consequences as nausea, vomiting, diarrhea, heartburn and cephalgia.

Interaction with other drugs

Thioctic acid In vitro interacts with metal ions, therefore drugs containing ionic complexes, for example, cisplatin, reducing their effect. The drug enhances the effect of insulin.

It is recommended to separate the intake of α-lipoic acid and drugs containing metals (for example, iron or magnesium). The same applies to dairy products. People taking thioctic acid preparations are strictly not recommended to drink alcohol.

Ethanol and its breakdown products reduce the effectiveness of the drug.

If the drug is taken orally, the single dose will be 600 mg. When administered intravenously, 300 mg to 600 mg per day can be administered. Typically, injections are given for 14-28 days, followed by maintenance treatment. Tablets are used for these purposes. Usually the drug is taken once a day in the morning half an hour before the first meal, washed down with water. Depending on the pathology, the dose can be adjusted by the doctor.

Taking the medication for preventive purposes and as a fat burner has its own characteristics. Therefore, a legitimate question arises: how to take lipoic acid for weight loss?

For prevention, the human body needs 50 mg of the active substance per day. To achieve a slim figure, it is better to consult a specialist before taking medication. Regarding lipoic acid, the instructions for use indicate that the individual dosage will depend on:

1. From individual (height and weight) body parameters.
2. Presence of chronic diseases.
3. Load intensity.

The minimum daily dose is 25 mg of the active substance. The average daily dose for a healthy person who is not obese and leads a moderately active lifestyle is 50 mg. In addition to the dosage, it is important to consider a few more points: how many times to take the tablets and when? When answering the question of how to take lipoic acid for weight loss, you need to focus on the time of administration. It is most effective to take the product at one of three time intervals of your choice:

• in the morning before meals;
• immediately after an active workout;
• in the evening, after eating.

Taking the medication should be combined with eating food containing plenty of carbohydrates, which will enhance the effect of taking it.

For example, after a workout it is good to eat some dates with honey. If you combine taking the drug with breakfast, it is effective to eat buckwheat porridge.

We talked about such a useful compound as Alpha Lipoic Acid: instructions for using the drug - you are probably also interested in the price. Let's talk about this below. And about the opinion of the patients who tried the drug in action.

Cost of the drug and a brief overview of reviews

This is one of the cheapest medications; you can find lipoic acid starting at 27 rubles. For example, for preventive purposes, you can buy tablets of 12 mg of lipoic acid at a pharmacy price of about 34 rubles. Or Alpha lipoic acid at a pharmacy price of about 47 rubles, in a dosage of 50 mg.

But if you manage to buy Alpha Lipoic Acid at this price, then you are lucky. The ability to purchase this product at this price depends on the region. In some regions, you can freely buy this medication at a pharmacy. Other pharmacy chains are full of analogues that cost much more. Their price ranges from 600 to 1800 rubles. You can buy alpha lipoic acid under a different trade name, for example, Berlition-300 at a price of 650 rubles. Alpha lipoic acid, priced at about 1,800 rubles, is offered by pharmacy chain sellers in the form of the drug Thioctacid BV in a dose of 600 mg.

This is basic information about lipoic acid: instructions for use, price of the product, and possibilities of use. It remains to talk about reviews of this drug.

Reviews for lipoic acid are mostly positive. This refers to a drug that has been used for prophylactic and therapeutic purposes. Some patients experienced that their body reacted to the medication with an allergic reaction; few patients experienced other side effects of the drug. Oddly enough, the main negative point for Alpha lipoic acid, reviews cite the inaccessibility of its cheap option.

As for the medication as a fat burner, lipoic acid for weight loss has the most controversial reviews. From laudatory responses to statements of her complete ineffectiveness in this capacity. Of course, taking into account the fact that the diet was not changed and physical activity did not increase. Once again, I would like to note that for those who are in search of a “pill for the lazy,” this remedy is unlikely to help.

And even if you find lipoic acid reviews for weight loss in the most superlative degrees. Girls will report that they ate and moved as before and were actively losing weight from pills alone; you should not rely on such reviews. The drug is not capable of this.

Doctors' reviews of Lipoic acid are mostly positive, as a drug for auxiliary therapy. They recognize its unique properties and ability to provide a beneficial therapeutic effect in many diseases.

Video: Lipoic acid as an aid to weight loss

In cosmetology and medicine, several types of acids are known that have a beneficial effect on human health. For example, a drug such as lipoic acid (thioctic acid) is successfully used to normalize the body's metabolism, regulate lipid and carbohydrate metabolism, and control cholesterol levels. What is this substance, why is thioctic acid valuable for our health, how effective is it, and for what purpose is it used?

The healing properties of lipoic acid

Almost all organs of the human body contain lipoic (thioctic) acid, but the kidneys, heart, and liver contain it in larger quantities. This substance helps reduce the toxic effects of any toxic substances and heavy metal salts. It improves liver function, protects it from damaging factors, and has hepatoprotective and detoxification properties. If there is a lack of thioctic (lipoic) acid in the body, drugs containing it are prescribed.

By interacting with vital vitamins E and C, enhancing their properties, alpha-lipoic acid (another name for it) fights free radicals. It reduces the level of lipids, cholesterol and sugar in the blood, improves the nutrition of the nervous system, has some properties similar to B vitamins, protects the body from ultraviolet rays, and regulates the activity of the thyroid gland. Thioctic (lipoic) acid is the active substance of the drug of the same name and acts as a compound that provides a therapeutic effect.

Indications for use

It is necessary to use thioctic (lipoic) acid in such cases as:

• diabetic, alcoholic polyneuropathy;
• violation of various types of sensitivity in the extremities;
• atherosclerosis of heart vessels;
• liver diseases (viral, toxic hepatitis, cirrhosis);
• treatment of any poisoning (for example, salts of heavy metals);
• carrying out activities to improve vision;
• stimulation of brain function;
• providing support for the thyroid gland.

How to take for weight loss?

The main properties of lipoic (thioctic) acid: strengthening and normalization of all processes occurring in the human body. This substance affects the suppression of hunger, promotes the consumption and destruction of fat reserves into simple substances, which become energy, and accelerates metabolic processes. Therefore, it is used for weight loss. The daily norm for a healthy person is 25-50 mg of lipoic (thioctic) acid. In order to lose weight, doctors recommend dividing the daily dose into three doses: before or after breakfast, physical activity, and dinner.

People who have metabolic disorders, as well as elevated blood sugar levels, are prescribed higher doses of this substance. You cannot combine the drug with iron-containing products and alcohol. A dietologist should prescribe lipoic (thioctic) acid for weight loss. Side effects of an overdose of this substance include:

• nausea;
• vomit;
• allergic reactions;
• headache.

Carnitine and alpha lipoic acid in bodybuilding

Carnitine (L-carnitine) is an amino acid that activates fat metabolism in the human body. This substance, accumulating in muscles and promoting the breakdown of fats in muscle cells, provides muscle tissue with long-term energy. Which is very important during intense strength training. Many carnitine supplements also contain alpha lipoic acid (ALA). It converts substances received by the body into energy, helps regulate blood sugar levels, and prevents the development of obesity.

ALA is a strong antioxidant, helps reduce the destruction of proteins and cells, and helps to quickly restore strength after intense training. Carnitine is taken before workouts, which helps you exercise longer without experiencing fatigue. Bodybuilding athletes also take alpha-lipoic acid along with a substance called "" to effectively build muscle mass.

The use of dietary supplements leads to improved heart function, faster recovery of the body due to normalization of cell metabolic processes, and reduction of subcutaneous fat. The maximum results from using the drugs are achieved with a properly designed training program and a balanced diet. Both ALA and carnitine are not doping, so they can be used in sports nutrition without any restrictions.

ALA in cosmetics and cosmetology

ALA (alpha lipoic acid) can give the skin a healthy appearance, make it soft, smooth and beautiful in the shortest possible time. It is a natural substance, particles of which are present in every cell of the human body. ALA is similar to vitamin C in its action. Protection against free radicals is the main function of this substance.

In cosmetology, a cream is used, the component of which is lipoic (thioctic) acid. When using products containing this substance, the effect of vitamins E, A, C is enhanced, metabolism is accelerated, cells are renewed, getting rid of toxins and sugar. The most important thing is that ALA gives a rejuvenating effect, facial skin becomes tightened, well-groomed, acne and dandruff disappear, and microscopic wounds grow and heal faster.

You can purchase ALA in powder or liquid form. When added to a cream or tonic, capsules with alpha lipoic acid are used immediately; they cannot be stored for a long time, otherwise they will lose their healing properties. ALA and the products of which it is a component must be stored in places protected from light. In cosmetology, the use of this substance leads to smoothing and tightening of the skin, restoring its natural color.

Use during pregnancy and breastfeeding

Lipoic (thioctic) acid is successfully used to treat many diseases. Regardless of its medicinal properties, during pregnancy and breastfeeding this remedy is prescribed with great caution, and some sources recommend avoiding its use altogether. Since opinions vary about the safety of thioctic acid for nursing and pregnant women, it is best to consult your doctor before using this drug.

Contraindications and side effects

Contraindications to the use of lipoic (thioctic) acid:

• children under 6 years of age (safety of use has not been proven);
• allergic reaction to the drug and its components;
• hypersensitivity to thioctic (lipoic) acid;
• pregnancy;
• breastfeeding period.

Possible side effects:

• pinpoint hemorrhages;
• platelet dysfunction;
• increased intracranial pressure;
• a sharp decrease in blood sugar levels;
• double vision;
• convulsions;
• nausea, feeling of heaviness in the abdomen;
• allergic reactions;
• heartburn.

Trade name of the drug: Lipoic acid

International nonproprietary name:

Dosage form:

Description: yellow or greenish-yellow film-coated tablets. The cross section shows two layers.

Compound:

Pharmacotherapeutic group:

ATX Code: .

Pharmacological properties
Lipoic acid is a coenzyme involved in the oxidative decarboxylation of pyruvic acid and alpha-keto acids and plays an important role in the body's energy balance. By the nature of the biochemical action, lipoic acid is similar to B vitamins. Lipoic acid is involved in the regulation of lipid and carbohydrate metabolism, has a lipotropic effect, affects cholesterol metabolism, improves liver function, and has a detoxifying effect in case of poisoning with heavy metal salts and other intoxications.

Indications for use
Used in complex therapy of patients with steatohepatitis of various etiologies and in case of intoxication.

Directions for use and doses
Inside after meals. Adults - 0.05 g (2 tablets of 0.025 g) 3-4 times a day. Children over 6 years old - 0.012-0.024 g (1-2 tablets of 0.012 g each) 2-3 times a day. The course of treatment is 20-30 days. If necessary, as prescribed by a doctor, a second course of treatment is carried out after 1 month.

Side effect
Dyspeptic symptoms, allergic reactions, and hypoglycemia are possible.

Contraindications
Hypersensitivity to the drug.

Warnings:
Caution should be exercised when prescribing the drug to patients with diabetes mellitus, hyperacid gastritis, gastric and duodenal ulcers, as well as those with a tendency to allergic reactions. Avoid drinking alcohol during treatment.

Interaction with other drugs
Potentiates the anti-inflammatory effect of glucocorticoids. Reduces the effectiveness of cisplatin. Enhances the effect of insulin and oral hypoglycemic agents.

Release form
Film-coated tablets, 0.012 g and 0.025 g. 10 pieces in blister packs or 50, 100 pieces in jars with a screw neck with screw-on plastic lids or aluminum caps. Each jar or 5 blister packs along with instructions for use are placed in a cardboard pack.

Storage conditions:

Best before date
3 years. Do not use after the expiration date stated on the package.

Conditions for dispensing from pharmacies
Over the counter.

Manufacturer
JSC "Pharmstandard - Marbiopharm". Republic of Mari El, 424000, Yoshkar-Ola, K. Marx St., 12

Hello, dear readers! Glad you are reading my blog! Today we will talk about such a simple but interesting drug as alpha-lipoic acid. So, let's figure out what this substance is and why we need it.

Pharmacology is developing, and along with it, the knowledge of ordinary people about certain drugs that can help solve their problems is growing. Various acids have long been used in medicine, cosmetology and sports. Alpha lipoic acid's indications for use also deserve special attention. In a sports environment, it is used as a substance that controls cholesterol levels, lipid and carbohydrate metabolism, and also as a metabolism regulator.

What is alpha lipoic acid?

This substance, also known as thioctic acid, belongs to the category of biologically active substances similar in action to vitamins. It is a powerful antioxidant and also has the ability to enhance the effect of insulin, which is why it is used in the treatment of diabetes.

Physical properties of the substance: fine powder, light yellow in color, has a bitter taste. It dissolves poorly in water, but well in alcohol.

The main food sources of acid are by-products (heart, liver, kidneys of animals), as well as rice, spinach, etc.

Properties of thioctic acid

1. Manifesting itself as an antioxidant, it is successfully used in the prevention and treatment of cancer;
2. Takes part in oxidative and biochemical processes in the body;
3. Reduces the concentration of glucose in the blood, which is also a factor in the treatment of diabetes (reduces insulin resistance);
4. Regulates carbohydrate and fat metabolism;
5. Increases glycogen content in the liver;
6. Reduces the development of viruses;
7. Reduces manifestations of neuropathy;
8. Controls cholesterol levels;
9. Regulates the functioning of the thyroid gland;
10. Prevents the development of cataracts (which can lead to blindness in diabetes);
11. It has restorative properties, helping the body regain strength after physical exertion;
12. Reduces symptoms of intoxication (removes toxins, alcohol and heavy metals);
13. As an additional component for intravenous injections, it can reduce the side effects of certain drugs.

Indications for use of alpha lipoic acid

1. Diseases of the peripheral nervous system associated with alcohol dependence;
2. Diseases of the peripheral nervous system (neuropathy) resulting from diabetes;
3. Metabolic syndrome;
4. Fatty liver degeneration;
5. Poisoning with alcohol, heavy metals, drugs, food;
6. Cirrhosis of the liver;
7. Atherosclerosis of the heart vessels;
8. Disturbances in the activity of the thyroid gland;
9. Activation of cerebral circulation and mental activity;
10. During rehabilitation therapy after a stroke;
11. Reduced immunity;
12. Heavy physical activity;
13. Work related to toxic substances (as prevention).

Alpha lipoic acid in cosmetology

This substance is also actively used as an external agent. If, when taken internally, it manifests itself as, then when used externally, thioctic acid is more like vitamin C.

This substance has the following effect on the skin:

• Gives a healthy fresh look;
• Rejuvenates;
• Leaves skin soft and smooth;
• Works as an antioxidant, slowing down the withering process;
• As part of cosmetics containing vitamins A, C, E - increases their effect;
• Eliminate dandruff;
• Treats acne;
• Tightens pores;
• Protects against ultraviolet radiation;
• Has an anti-inflammatory effect;
• Accelerates skin healing.

Alpha lipoic acid is used as one of the main ingredients in many anti-aging cosmetic products.

For home use, you can use capsules with the substance, but it is worth remembering that they cannot be stored for a long time when opened, as the healing properties will disappear. Products containing thioctic acid are stored in places protected from sunlight.

At home, this substance can be used as a component of a mask, or by adding it to your everyday cosmetics - cream or tonic.

Alpha lipoic acid in sports

I know very well how inventive and resourceful athletes can be. I myself have witnessed more than once the measures that people go to in order to increase their physical potential. Therefore, I am not surprised that this substance is so popular among bodybuilders.

The mechanism of action of this biologically active substance is very simple. As an antioxidant, thioctic acid prevents the development of free radicals, which are produced in large quantities by the body after hard training (as a reaction to stress). In other words, the substance is a powerful restorer and relaxant.

It is considered a good anti-catabolic, that is, it has a protective effect on the body’s cells, preventing the destruction of proteins. Taking alpha lipic acid allows an athlete to withstand higher physical loads without losing performance (than if they did not take the drug).

And since thioctic acid regulates glucose levels, muscles do not waste glycogen, but are constantly filled with the necessary carbohydrates, which affects performance and muscle growth.

Contraindications and side effects

Taking the substance is not allowed in the following cases:

• Age up to 6 years;
• Pregnancy and lactation period;
• Hypersensitivity (individual intolerance) and allergies.

Sometimes the following effects may occur:

Conclusion

Now you know more about alpha lipoic acid and its indications for use. Still, consult your doctor before use, as each case is individual.

I hope I was useful to you, dear readers. Don’t forget to subscribe to my blog updates, and also share links to this article with your friends. Be healthy!

Best regards, Vladimir Manerov

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