Is it possible to use furosemide biseptol together? Biseptol is a powerful antimicrobial agent for the fight against cystitis, pyelonephritis and other infectious diseases. Special instructions and possible side effects

Cystitis occupies a leading place in the structure of genitourinary diseases, which is due to many factors. Patients of different sexes and ages are susceptible to pathology, but women, especially during menopause, are most susceptible to bladder infections. Moreover, the frequency of exacerbations and complicated forms of the disease increases several times after 60 years.

Despite the insidiousness of cystitis and its tendency to recur, modern pharmacology leaves no chance for the disease. Although many doctors prefer new generation antibiotics, biseptol for cystitis and urogenital infections in some cases is the only treatment option. The effectiveness of a time-tested antibacterial drug has been confirmed by clinical studies and statistics of therapeutic use in different age groups of patients.

Why is it necessary to take antibacterial drugs to relieve cystitis, and can the disease go away spontaneously? It can be unequivocally stated that inflammation of the bladder always begins with an acute form and, if symptoms are ignored, it transforms into a chronic pathology with frequent relapses. A long-term inflammatory process significantly reduces immunity and impairs bladder function, which ultimately leads to kidney disease, urinary incontinence and social maladjustment. Medicines from the group of antibiotics and antiseptics are the first choice and, in combination with antispasmodics, antiprotozoal and herbal medicines, immunomodulators and physiotherapy, allow you to quickly get rid of cystitis.

The goals of antibacterial therapy are to stop the inflammatory process, restore social activity and prevent relapses. When choosing medicines, not only the activity of the active ingredients of the pharmaceutical form is taken into account; an important condition is safety and minimization of side effects. All requirements are met by the broad-spectrum drug Biseptol.

Medicine forms and composition

Biseptol or Co-trimaxozole are classified as sulfonamide synthetic antibacterial drugs containing several active substances. Sulfamethoxazole blocks the synthesis of folic acid in microorganisms, which ultimately leads to their death, and Trimethoprim enhances the effect of the main component.

The drug is rapidly absorbed and reaches maximum concentration in the blood plasma after a few hours. The number indicated after the name of the drug, for example, “Biseptol 480,” indicates the total content of the main active ingredients: sulfamethoxazole - 400 mg and trimethoprim - 80 mg. Manufacturers produce several forms of the antibacterial agent, which allows its use in different age categories of patients with cystitis and urogenital infections:

• Tablets 480 mg and 120 mg are intended for adults and children, respectively.
• In liquid form - syrup and suspension 240 mg.
• In ampoules of 480 mg for the preparation of solutions, indicated for intravenous or intramuscular administration in a hospital setting.

In everyday practice, the best way to treat cystitis in adults is considered to be the use of a tablet form at a dosage of 480 mg and a Biseptol 240 suspension for children.

Advantages of the drug

In more than 90% of cases of cystitis, the causative agent of genitourinary infection is Escherichia coli. The advantages of the combination are considered to be a powerful bactericidal effect against this particular pathogen, as well as other gram-negative and gram-positive bacteria: salmonella, toxoplasma, listeria, streptococcus, meningococcus, chlamydia, klebsiella, etc. A precisely calibrated combination of Biseptol components has the necessary synergistic effect on pathogenic microflora and helps slow down the emergence of resistance.

The main condition for prescribing Biseptol is the sensitivity of the pathogen to the active substances. An equally important aspect is to carry out a short course of treatment - no more than 7 days; with uncontrolled use of the drug, rapid addiction and high resistance of the microflora are observed. When this condition occurs, the inflammatory process transforms into a latent form, which is difficult to treat. Therefore, if characteristic symptoms appear, you should not hesitate to contact a urologist, who, based on examination data, will select the necessary pharmaceutical form and dosage of the drug.

The course of treatment is selected individually depending on the severity of the condition and the patient’s medical history. The daily dose for different age categories is presented in the table; it should also be noted that 5 ml of the liquid form of the medicine contains 240 mg of the active substance. The drug is equipped with a measuring spoon, so dosing is not difficult.

Special instructions and possible side effects

For children in the first months of life, the drug is prescribed in liquid form - in the form of a suspension or syrup. For cystitis in women, it is recommended to take Biseptol for the first three days, up to 8 tablets per day, 480 mg each, with a sufficient amount of liquid. Usually the drug is well tolerated, but in some cases headache and dizziness, loss of appetite, diarrhea, and cramping pain in the lower abdomen may occur. If such symptoms appear, the drug is replaced with an alternative one. You can also highlight the mandatory rules for taking Biseptol:

1. The interval between taking the drug is 12 hours, for example, if the morning dose took place at 10:00, then the next dose is taken at 22:00.
2. Biseptol has a depressing and irritating effect on the pancreas and stomach walls, so the medication should be taken only after meals.
3. The treatment regimen requires the use of the medicine for at least five days, otherwise the risks of complications are high.

Only a doctor can decide on the need to increase the dosage of Biseptol and continue therapy for more than 5 days. In case of complications or in the absence of the necessary therapeutic effect, alternative medicines are used. The total daily dose of antibiotic can also be adjusted, with the prescription of maintenance medications.

Contraindications

Although Biseptol is one of the few first-choice antibacterial drugs in infants, it is not recommended for use in infants under six weeks of age. A clear contraindication for use in women is the period of pregnancy and lactation, which is due to the penetration of active substances through the placental barrier. The drug is not recommended for patients with blood diseases and high sensitization of the body.

120 mg per day or 2 tablets of 240 mg after meals with plenty of liquid. In especially severe cases, 6 tablets per day are prescribed. The intake should be divided into two parts - morning and evening. Therapy usually lasts no more than 5 days. For long-term treatment, take 2 tablets of 120 mg per day.

For children, the drug is prescribed in the form of a suspension, twice a day. Each bottle of suspension has a measuring cap with divisions of 2.5, 5 and 7.5 ml. For those aged less than a year, 2.5 ml of medication is prescribed every 12 hours. If the child is between 1 and 3 years old, 5 ml is usually prescribed twice a day. From 4 years of age, you can take 10 ml of the drug, depending on the intensity of the disease and the pediatrician’s recommendations.

Biseptol has a number of side effects that can occur in case of overdose or improper use: spasms of the respiratory muscles, digestive disorders, nausea, diarrhea, jaundice, inflammation of the mucous membranes of the mouth. It is also possible that kidney function may deteriorate and allergic reactions may occur. Before taking the drug, you should consult your doctor and undergo the necessary tests. The medication is taken under the supervision of a specialist.

Dosage adjustments may also be necessary in elderly patients. The use of tablets during pregnancy and breastfeeding is prohibited.

note

You should not use Biseptol if you are intolerant to sulfonamides, which are included in the tablets. It is also recommended to carefully treat with the medicine if there are problems in the functioning of the kidneys and liver. For patients with kidney disease, a dose is prescribed depending on the current creatinine levels.

Instructions

"Biseptol" is used to treat acute and chronic bronchitis, pleural empyema, lung abscesses, bronchiectasis, and pneumonia. It is also prescribed for urethritis, pyelitis, chronic pyelonephritis, prostatitis, gonococcal urethritis, infectious diseases of the gastrointestinal tract, surgical and other infections, uncomplicated gonorrhea, septicemia. The drug is effective against pneumococci, staphylococci, typhoid bacillus, dysentery, E. coli, streptococci, Proteus. "Biseptol" has no effect on mycobacterium tuberculosis, Pseudomonas aeruginosa, or spirochetes.

"Biseptol" is taken after meals with the required amount of water. Adults and children over 12 years of age are prescribed 960 mg of the drug 2 times a day, for long-term treatment - 480 mg 2 times a day. In cases of severe infectious disease or its chronic form, the single dose is increased by 30-50%. Children aged 3 to 5 years are given 2 tablets. (120 mg) 2 times a day, aged 6 to 12 years - 4 tablets. (120 mg) or 1 tablet. (480 mg) 2 times a day. The duration of taking the drug is 5-14 days.

"Biseptol" can cause the following side effects: anorexia, vomiting, nausea, pseudomembranous colitis, diarrhea, abdominal pain, allergic manifestations on the skin (rash, urticaria). Possible development of epidermal toxic necrolysis, acute liver necrosis, aplastic anemia, hemolytic anemia, eosinophilia, allergic myocarditis, anaphylactic reaction, vascular edema, serum sickness, fever, chills, hepatitis, pancreatitis.

"Biseptol" is contraindicated in case of hypersensitivity to its components, during pregnancy and lactation, with damage to liver tissue, severe renal failure, severe hematological diseases. The drug is prescribed with caution for folic acid deficiency, bronchial asthma, and thyroid diseases.

In case of long-term treatment (more than 1 month), blood tests should be performed regularly to monitor hematological changes. Particular care must be taken when treating elderly patients with Biseptol. To prevent crystalluria, it is recommended to increase the amount of fluid consumed. During the period of treatment with Biseptol, it is not recommended to eat cauliflower, legumes, spinach, tomatoes, carrots, and excessive sun exposure should be avoided.

"Biseptol" is a broad-spectrum antimicrobial agent. This drug provides inhibition of pathogenic microorganisms that cause the disease and has a bactericidal effect. You can take Biseptol in the form of tablets, suspension and infusion solution.

Instructions

The drug "Biseptol" is prescribed for a number of infectious and inflammatory diseases. This remedy is used in the treatment of respiratory tract infections, in particular “Biseptol” is indicated in the treatment of bronchitis, pneumonia, as well as pleural empyema and lung abscesses. The drug is used in the treatment of infectious diseases of the genitourinary system: urethritis, prostatitis, pyelonephritis, salpingitis, gonorrhea. Biseptol is also used in the treatment of dysentery, diarrhea, cholera, typhoid fever and paratyphoid fever. The drug is effective for infectious lesions of the skin and tissues, including those prescribed for furunculosis and purulent formations. Biseptol is also used to treat sinusitis, otitis and meningitis.

Biseptol tablets should be taken after meals, 2 times a day. Children 2-5 years old are prescribed 240 mg, 5-12 years old - 480 mg per dose. Children from 12 years of age and adults use a dosage of 960 mg. For long-term treatment, the amount of the drug must be reduced to 480 mg, also taking the drug twice a day. The duration of therapy depends on the complexity of the disease and is 5-14 days. When treating chronic infections and severe disease, the one-time dose can be increased by 30-50%. When treating pneumonia, the medicine is taken at the rate of 100 mg of sulfamethoxazole per kg of patient weight per day. The drug should be taken for 2 weeks, the interval between dosages should be 6 hours. For gonorrhea, 2 g of sulfamethoxazole is indicated 2 times a day at intervals of 12 hours.

Biseptol suspension is indicated for adults and children from 3 months. The drug is taken every 12 hours. Babies 3-6 months are given 2.5 ml, 7 months - 3 years - 2.5-5 ml of the product. Children 4-6 years old are prescribed 5-10 ml, 7-12 years old - 10 ml of suspension. Adults and adolescents should take the medicine 20 ml at a time. Treatment should be carried out for 1.5-2 weeks, for dysentery - 5 days. Shake the bottle of suspension well before use.

Biseptol solution is administered intravenously. For children over 12 years of age, a single dosage is 10 ml of the product. Before administration, the medicine should be diluted in 250 ml of dextrose or sodium chloride solution. Biseptol is administered intravenously every 12 hours for 5 days. For particularly severe symptoms, the dosage can be increased to 3 ampoules with a frequency of administration 2-3 times a day. The children's daily dose of sulfamethoxazole is 30 mg/kg body weight. This amount of medicine should be used 2 times. The infusion should not last longer than 1.5 hours.

It is one of the most common inflammatory kidney diseases. Medicines for pyelonephritis can alleviate the patient’s general health and relieve symptoms. If the disease is not treated in a timely manner, there is a risk that it will become chronic, so it is important to contact a specialist after the first symptoms appear and know what medications are used to treat pyelonephritis.

Kidney inflammation is eliminated with complex drug therapy and other prescriptions.

Treatment program

The specialist, after the patient has passed all the tests, prescribes a course of treatment, which has the following program:

• diet;
• etiological therapy;
• non-steroidal anti-inflammatory drugs;
• phytotherapy;
• symptomatic therapy;
• treatment aimed at avoiding relapse of the disease.

Antibiotics

Treatment with antibacterial medications is the basis of therapy, since kidney pyelonephritis is often caused by bacterial infection. prescribed by a specialist in order to eliminate the infection and prevent the disease from becoming chronic. An IV is often prescribed. The most common antibiotics: Ampicillin, Amoxicillin, Vilprafen, Gentamicin.

Principles of treatment

Pyelonephritis should be treated with antibiotics according to the following principles:

• the medicine should not have a toxic effect on the kidneys;
• the drug must have a wide spectrum of action;
• the medicine must have bactericidal properties;
• The effect of the drug should not be affected by changes in the acid-base balance of urine.

Types of antibiotics

The following groups of antibiotics are used to treat pyelonephritis:

1. Penicillins. They act on gram-negative microflora and almost all bacteria, have a positive effect on the kidneys, therefore they are prescribed even to pregnant women. Known penicillins: Amoxiclav, Ampicillin, Amoxicillin.
2. Cephalosporins. They have little toxicity and have a powerful effect on most bacteria; they are prescribed as intramuscular injections. Names of the drugs: Suprax, Cephalexin, Cefaclor, Cifran and Tamycin.
3. Aminoglycosides. They are used to treat acute pyelonephritis, as they have a powerful antibacterial effect. Medicines are not prescribed to pregnant women and elderly people, since there is a nephrotoxic effect on the body. The following aminoglycosides are distinguished: “Netilmicin”, “Amikacin”, “Gentamicin”.
4. Carbapenems. They have a broad effect on various forms of bacteria. A well-known representative is “Imipinem”.
5. Macrolides. Affects gram-positive bacteria and chlamydia. These antibiotics are the least toxic of all. List of macrolides: Vilprafen, Roxithromycin, Azithromycin and Tetraolean.
6. Fluoroquinolones. They are often used in the treatment of acute pyelonephritis, as they have a strong effect, due to which recovery occurs quite quickly. The following medications are often used: Moxifloxacin, Nolitsin, Levofloxacin.
7. Lincosamines. Drugs in this group have an effect only on staphylococci and streptococci, therefore lincosamines are often prescribed in combination with aminoglycosides. Known lincosamines: Clindamycin, Lincomycin.

What medications should I take to relieve symptoms?

Treatment of pyelonephritis begins with doctors prescribing medications designed to relieve the symptoms of kidney pyelonephritis and restore the activity of the urinary system. For this, antispasmodics are used, for example, “No-shpa” and “Papaverine”. Then antibacterial drugs for pyelonephritis from the following groups are used: aminoglycosides, penicillins, cephalosporins. Non-steroidal anti-inflammatory drugs are also prescribed for pyelonephritis, which relieve pain and reduce inflammation. Ibuprofen, Diclofenac and Indomethacin are used.

What antimicrobial drugs should be used?

Etiological therapy for pyelonephritis consists of restoring normal urine flow and eliminating infections in the kidneys. The following groups of drugs are used for this:

1. Nitrofurans. The main effect is based on the elimination of Trichomonas and Giardia, and they are used most often during exacerbation of the chronic form of the disease. Famous representatives: “Furadonin” and “Furamag”.
2. Fluoroquinolones. They act on pneumococci, intracellular pathogens, anaerobes and gram-positive bacteria. The following drugs are used: Norfloxacin, Ofloxacin and Ciprofloxacin.
3. Sulfonamides. Used to eliminate gram-negative bacteria and chlamydia. Well-known drugs: Urosulfan and Biseptol.
4. Hydroxyquinolines. The action of the tablets is aimed at eliminating gram-positive and gram-negative bacteria. The most famous medicine is Nitroxoline.
5. Phosphonic acid derivatives. The drug in this group is called “Monural”, has a broad effect on the kidneys and eliminates almost all gram-positive bacteria.

Treatment of pyelonephritis is a long process that must be carried out under the close supervision of a doctor. All drugs that are prescribed for inflammation of the renal collecting system are aimed at eliminating the pathogen, restoring normal urine flow and have anti-inflammatory activity.

In addition to etiotropic treatment that directly affects the cause of the disease (antibacterial tablets and injections), drugs that act pathogenetically are used for pyelonephritis: they eliminate factors for the development of the disease and eliminate symptoms.

Canephron-N

Canephron-N is a powerful uroseptic drug. Available in the form of dragees and oral solution.

The active ingredient is a hydroalcoholic extract of plant biocomponents (lovage root, centaury, rosemary).

Mechanism of action

When ingested, Canephron-N reaches its maximum concentration in the excretory system of the kidneys, where it has a local anti-inflammatory, antimicrobial and antiseptic effect. It relieves spasms of the urinary tract due to its gentle effect on the smooth muscles of the kidneys. The product also has a mild diuretic effect.

Cyston is a multicomponent herbal antiseptic drug. Available in tablet form.

Active ingredient: plant extracts:

• flowers of stalked bicarp;
• reed saxifraga;
• madder stems;
• rhizomes of membranous sylvestris;
• strawflower seeds;
• Onosma bractae;
• sweet basil;
• fava bean seeds;
• mimosa seeds;
• mountain mumiyo.

Mechanism of action

Cystone, like many other herbal preparations, after ingestion of the body accumulates in the kidney tissues. Treatment of pyelonephritis occurs due to local antiseptic action: Cyston tablets enhance the effect of antibiotics and sanitize the pyelocaliceal system of the kidneys and urinary tract.

5-NOK

5-NOK is a synthetic agent with antibacterial activity. Release form: tablets with a dosage of 50 mg.

The active ingredient is nitroxoline from the group of oxyquinolines. Due to the large number of adverse reactions, the feasibility of its use for the treatment of pyelonephritis is currently being considered.

Mechanism of action

Treatment of genitourinary diseases is based on the antibacterial effect of the drug: nitroxoline is able to bind to metal-containing enzyme catalysts of the microbial cell and block metabolism in it. This stops the reproduction and pathological activity of bacteria. Like other drugs from the group of hydroxyquinolines, 5-NOK is active against both gram-positive and gram-negative microorganisms. With its help, you can treat not only kidney inflammation, but also other bacterial infections of the urinary system (cystitis, urethritis, etc.).

Biseptol

Biseptol is a combined antimicrobial agent active against the main pathogens of pyelonephritis. The produced form is tablets (120, 480 mg).

The active ingredient is a combination of trimethoprim and sulfomethoxazole (co-trimoxazole).

Mechanism of action

The active components that make up the drug, when ingested, are absorbed into the blood and concentrated in the kidney tissues. Sulfomethoxazole, similar in structure to PABA (para-aminobenzoic acid), interferes with the synthesis of dihydrofolic acid and prevents the integration of PABA into pathogen cells. Biseptol is able to treat inflammatory processes even of high activity.

Nolicin is a drug from the group of fluoroquinolones that has antibacterial activity. Available in the form of tablets with a dosage of 400 mg.

The active ingredient is norfloxacin.

Mechanism of action

Nolitsin is concentrated in the kidneys and has a bactericidal effect. The active substance blocks the enzyme DNA gyrase and destabilizes the genetic chain of microorganisms. Currently, fluoroquinolone drugs are the drugs of choice in the treatment of inflammatory diseases of the urinary system. Nolitsin and its analogues allow you to get rid of the causative agent of pyelonephritis within 7-10 days.

Furamag

Furamag is an antimicrobial agent from the nitrofuran group. The release form of the medicine is capsules (25, 50 mg).

The active ingredient is potassium furazidine.

Mechanism of action

Acting at the level of the kidneys, Furamag suppresses the main biochemical processes in the pathogen cell, which leads to its death. Treatment with the drug is active against a wide group of pathogens (gram-positive, gram-negative, Proteus, Klebsiella, protozoa, mycoplasma, etc.).

Phytolysin is a complex herbal preparation. Available in the form of a thick paste for oral administration.

Active ingredient - extracts:

• goldenrod;
• knotweed shoots;
• horsetail shoots;
• onion peel;
• wheatgrass rhizomes;
• lovage root;
• parsley;
• as well as a mixture of essential oils (peppermint, sage, orange, Scots pine).

Mechanism of action

Herbal preparations, including phytolysin, have a local anti-inflammatory and antiseptic effect. This additional treatment of pyelonephritis relieves symptoms of the disease within 10-14 days from the start of therapy.

Furadonin is a synthetic antimicrobial agent. Release form: tablets 50 or 100 mg.

The active substance is nitrofurantoin.

Mechanism of action

The active ingredient of the drug has a bactericidal effect, destroys the cell wall and promotes the death of microorganisms.

Furazolidone is a drug with antibacterial activity from a group that is classified as drugs with a broad antimicrobial effect. The release form of the medicine is 0.05 g tablets.

The active substance is furazolidone, drugs in its group belong to nitrofuran derivatives.

Mechanism of action

When ingested, it can penetrate all organs and systems. It is exported by the kidneys, and here it has the main therapeutic effect. The active components of the drug are capable of inhibiting some of the body's protective enzyme systems and blocking the proliferation of microbial cells.

Treatment with furazolidone is effective against inflammatory processes in the kidneys and urinary system caused by bacterial flora (Streptococcus saprophyticus, Staphylococcus spp., Escherichia coli, etc.), salmonella, mycoplasma, Klebsiella and some protozoa.

No-shpa

No-spa is a well-known antispasmodic agent. Available in the form of 40 mg tablets.

The active substance is drotaverine hydrochloride, which is an isoquinoline derivative.

Mechanism of action

Like similar antispasmodic drugs, no-spa inhibits the phosphodiesterase enzyme involved in muscle energy metabolism. Thanks to this, the smooth muscles of the entire body, including the organs of the urinary system, relax.

Attention! Treatment with no-spa and other muscle relaxants is possible only in the absence of a mechanical obstruction that disrupts the outflow of urine from the kidneys (for example, tumors, prostate adenoma, ureteral stenosis).

Diclofenac is a broad-spectrum anti-inflammatory drug. Release form: tablets 25, 50 mg and solution for injection 75 mg/3 ml.

The active ingredient is diclofenac sodium, from the group of non-steroidal anti-inflammatory drugs.

Mechanism of action for pyelonephritis

NSAIDs, including diclofenac, inhibit cyclooxygenase, a key enzyme that triggers a cascade of responses. Due to this, the production of the main inflammatory proteins - PGE, prostocyclins, leukotrienes - is inhibited.

Treatment with diclofenac is indicated for an active inflammatory process in the kidney tissues, a clear clinical picture of the disease and severe symptoms of intoxication. Prescribing NSAIDs without etiotropic antibiotic therapy is not recommended.

Immunotherapy for inflammatory kidney diseases

Inflammation is the body’s response to the introduction of a pathogen. In order to activate defenses and treat possible immunodeficiency, immunomodulators are prescribed.

• Viferon is a rectal suppository, the active component of which is recombinant human interferon. It has an immunostimulating, antiviral effect and has minimal side effects.
• Genferon is another interferon-based drug. The clinical effectiveness of the drug lies in reducing the effects of intoxication and accelerating the healing of the inflammatory focus in the kidney tissue, which promotes rapid recovery.

Treatment of pyelonephritis with interferon drugs can shorten the course of antibiotic therapy by an average of 7-10 days.

Herbal remedies for the treatment of pyelonephritis

As maintenance therapy for pyelonephritis in the remission stage, herbal medicines that have an antiseptic and mild diuretic effect are often prescribed. The kidney collection includes:

• St. John's wort shoots;
• bearberry;
• parsley rhizome;
• series;
• strawberry leaves;
• lovage;
• violet;
• sage.

Long-term use of the drug is possible as decongestant, uroseptic therapy, but Regular monitoring of urine tests is recommended (once every 3 months).

Analgesics

Painkillers are prescribed for symptomatic treatment of the disease. Pain syndrome can be relieved (with pyelonephritis it is often associated with spasm of the urinary tract) with the help of drugs:

• Ketanov (active component - ketorolac) is an NSAID with an analgesic effect, which is available in the form of 10 mg tablets and 3% 1 ml injection solution;
• Analgin (metamizole sodium) is an analgesic from the group of pyrozolones, produced in the form of tablets 500 mg and a solution of 50% 2 ml.

Vascular drugs

For the treatment of acute pyelonephritis in a hospital, vascular agents are sometimes prescribed. This improves blood circulation in the mycocirculatory vessels and reduces the risk of developing necrosis of renal tissue. The drugs of choice are:

• Trental is used intravenously: 20 mg/5 ml of the drug + 400 ml saline. solution for one administration.
• Curantil (a drug with an antiplatelet effect) is available in the form of 25 mg tablets.

Treatment of acute inflammation of renal tissue should be carried out in a hospital under the supervision of a nephrologist, exacerbation of the chronic form of the disease can be treated at home according to an algorithm compiled by the local doctor.

Pathogenetic and symptomatic treatment of pyelonephritis, together with antibiotic therapy, ensures rapid sanitation of the source of infection, eliminates inflammation and reduces the risk of exacerbations and chronic renal failure.