What does erythromycin ointment help with? Special information for healthcare workers

Macrolide antibiotic

Active substance

Erythromycin

Release form, composition and packaging

white or almost white, round, biconvex; On a cross section, one white layer is visible.

Excipients: povidone - 9.45 mg, crospovidone - 13.5 mg, calcium stearate - 4.14 mg, talc - 10.35 mg, potato starch - up to kernel weight 450 mg.

Shell composition: cellacephate 16.2 mg, titanium dioxide 0.8 mg, castor oil 3 mg.

10 pieces. - contour cellular packaging (1) - cardboard packs.
10 pieces. - contour cell packaging (2) - cardboard packs.

Enteric film-coated tablets white or almost white, oval, biconvex; A cross-section shows one white layer.

Excipients: potato starch, polyvinylpyrrolidone (povidone), Kollidon CL-M (crospovidone), polysorbate 80 (Tween 80), calcium stearate, talc.

Shell composition: cellulose acetylphthalyl, medicinal castor oil, titanium dioxide.

5 pieces. - contour cellular packaging (1) - cardboard packs.
5 pieces. - contour cell packaging (2) - cardboard packs.
5 pieces. - contour cell packaging (3) - cardboard packs.
5 pieces. - contour cell packaging (4) - cardboard packs.
5 pieces. - contour cell packaging (5) - cardboard packs.
5 pieces. - contour cell packaging (6) - cardboard packs.

pharmachologic effect

[I] - Instructions for medical use are approved by the pharmacological committee of the Ministry of Health of the Russian Federation

A bacteriostatic antibiotic from the macrolide group, reversibly binds to the 50S subunit of ribosomes in its donor part, which disrupts the formation of peptide bonds between amino acid molecules and blocks the synthesis of microbial proteins (does not affect the synthesis of nucleic acids). When used in high doses, it can exhibit a bactericidal effect. The spectrum of action includes gram-positive (Staphylococcus spp., producing and non-producing penicillinase, including Staphylococcus aureus; Streptococcus spp. (including Streptococcus pneumoniae, Streptococcus pyogenes), alpha-hemolytic streptococcus (Viridans group), Bacillus anthracis, Corynebacterium diphtheriae, Corynebacterium minutissimum) and gram-negative microorganisms (Neisseria gonorrhoeae, Haemophilus influenzae, Bordetella pertussis, Brucella spp., Legionella spp., including Legionella pneumophila) and other microorganisms: Mycoplasma spp. (including Mycoplasma pneumoniae), Chlamydia spp. (including Chlamydia trachomatis), Treponema spp., Rickettsia spp., Entamoeba histolytica, Listeria monocytogenes.

Gram-negative rods are resistant: Escherichia coli, Pseudomonas aeruginosa, as well as Shigella spp., Salmonella spp. and others. The sensitive group includes microorganisms whose growth is delayed at an antibiotic concentration of less than 0.5 mg/l, moderately sensitive - 1-6 mg/l, moderately resistant and resistant - 6-8 mg/l.

Pharmacokinetics

Absorption is high. Oral enteric-coated base forms of erythromycin have no effect on food intake. Cmax is achieved after oral administration in 2-4 hours. Protein binding is 70-90%.

Bioavailability - 30-65%. It is distributed unevenly in the body. It accumulates in large quantities in the liver, spleen, and kidneys. In bile and urine, the concentration is tens of times higher than the concentration in plasma. Penetrates well into the tissues of the lungs, lymph nodes, middle ear exudate, prostate secretions, sperm, pleural cavity, ascitic and synovial fluid. The milk of lactating women contains 50% of the plasma concentration. It penetrates poorly through the BBB into the cerebrospinal fluid (its concentration is 10% of the drug content in plasma). During inflammatory processes in the membranes of the brain, their permeability to erythromycin increases slightly. Penetrates through the placental barrier and enters the blood of the fetus, where its content reaches 5-20% of the content in the mother's plasma.

Metabolized in the liver (more than 90%), partially with the formation of inactive metabolites. T1/2 - 1.4-2 hours, with anuria - 4-6 hours. Excretion with bile - 20-30% unchanged, by the kidneys (unchanged) after oral administration - 2-5%.

Indications

Bacterial infections caused by sensitive microflora:

• diphtheria (including bacterial carriage);
• whooping cough (including prevention);
• trachoma;
• brucellosis;
• Legionnaires' disease;
• erythrasma;
• listeriosis;
• scarlet fever;
• amoebic dysentery;
• gonorrhea;
• conjunctivitis of newborns;
• pneumonia in children;
• genitourinary infections in pregnant women caused by Chlamydia trachomatis;
• primary syphilis (in patients allergic to penicillins);
• uncomplicated chlamydia in adults (localized in the lower genitourinary tract and rectum) with intolerance or ineffectiveness;
• infections of the ENT organs (tonsillitis, otitis media, sinusitis);
• biliary tract infections (cholecystitis);
• infections of the upper and lower respiratory tract (tracheitis, bronchitis, pneumonia);
• infections of the skin and soft tissues (pustular skin diseases, including juvenile acne, infected wounds, bedsores, II-III degree burns, trophic ulcers);
• infections of the mucous membrane of the eyes;
• prevention of exacerbations of streptococcal infections (tonsillitis, pharyngitis) in patients with rheumatism;
• prevention of infectious complications during medical and diagnostic procedures (including preoperative bowel preparation, dental interventions, endoscopy, in patients with heart defects).

Contraindications

• hypersensitivity;
• hearing loss;
• simultaneous use of terfenadine or astemizole;
• lactation period.

WITH caution: arrhythmias (history); prolongation of the QT interval; jaundice (history); liver failure; renal failure.

Dosage

Single dose for adults and teenagers over 14 years old is 250-500 mg, daily - 1-2 g. The interval between doses is 6 hours. severe infections the daily dose can be increased to 4 g.

Children from 4 months to 18 years, depending on age, body weight and severity of infection - 30-50 mg/kg/day in 2-4 doses; children in the first 3 months of life- 20-40 mg/kg/day. For more severe infections, the dose may be doubled.

For treatment of diphtheria carriage- 250 mg 2 times/day. Course dose for treatment of primary syphilis- 30-40 g, duration of treatment - 10-15 days.

At amoebic dysentery adults- 250 mg 4 times/day, children- 30-50 mg/kg/day; Course duration is 10-14 days.

At legionellosis- 500 mg-1 g 4 times a day for 14 days.

At gonorrhea- 500 mg every 6 hours for 3 days, then 250 mg every 6 hours for 7 days.

For preoperative bowel preparation to prevent infectious complications— orally, 1 g 19 hours, 18 hours and 9 hours before surgery (3 g in total).

For prevention of streptococcal infection (for tonsillitis, pharyngitis) adults - 20-50 mg/kg/day, children- 20-30 mg/kg/day, course duration - at least 10 days.

For prevention of septic endocarditis in patients with heart defects- 1 g for adults and 20 mg/kg - for children, 1 hour before a therapeutic or diagnostic procedure, then 500 mg - for adults and 10 mg/kg for children, again after 6 hours.

At whooping cough- 40-50 mg/kg/day for 5-14 days. At pneumonia at children— 50 mg/kg/day in 4 doses, for at least 3 weeks. At genitourinary infections during pregnancy- 500 mg 4 times / day for at least 7 days or (if this dose is poorly tolerated) - 250 mg 4 times / day for at least 14 days.

U adults, at uncomplicated chlamydia and tetracycline intolerance- 500 mg 4 times a day for at least 7 days.

Side effects

Hypersensitivity reactions: allergic skin reactions (urticaria, other forms of rash), eosinophilia; rarely - anaphylactic shock.

Nausea, vomiting, gastralgia, tenesmus, abdominal pain, diarrhea, dysbacteriosis; rarely - oral candidiasis, pseudomembranous enterocolitis (both during and after treatment), impaired liver function, cholestatic jaundice, increased activity of liver transaminases, pancreatitis, hearing loss and/or tinnitus (when using high doses - more than 4 g/day, hearing loss after discontinuation of the drug is usually reversible).

Rarely - tachycardia, prolongation of the QT interval on the ECG, ventricular arrhythmias, including ventricular tachycardia (pirouette type) in patients with a prolonged QT interval.

Overdose

Symptoms: impaired liver function, up to acute liver failure, hearing loss.

Treatment:, careful monitoring of the state of the respiratory system. Gastric lavage is effective when taking a dose five times higher than the average therapeutic dose. Hemodialysis, peritoneal dialysis, and forced diuresis are ineffective.

Drug interactions

Drugs that block tubular secretion prolong T1/2 of erythromycin.

Incompatible with lincomycin, clindamycin and chloramphenicol (antagonism).

Reduces the bactericidal effect of beta-lactam antibiotics (penicillins, cephalosporins, carbopenems).

When taken simultaneously with drugs that are metabolized in the liver (theophylline, carbamazepine, hexobarbital, phenytoin, alfentanil, disopyramide, lovastatin, bromocriptine), the concentration of these drugs in plasma may increase (it is an inhibitor of microsomal liver enzymes).

Increases the nephrotoxicity of cyclosporine (especially in patients with concomitant renal failure). Reduces the clearance of triazolam and midazolam, and therefore may enhance the pharmacological effects of benzodiazepines.

When taken simultaneously with terfenadine or astemizole - the possibility of developing arrhythmia, with dihydroergotamine or non-hydrogenated ergot alkaloids - vasoconstriction to spasm, dysesthesia.

Slows down the elimination (increases the effect) of methylprednisolone, felodipine and coumarin anticoagulants.

When taken together with lovastatin, rhabdomyolysis increases.

Increases the bioavailability of digoxin.

Reduces the effectiveness of hormonal contraception.

special instructions

During long-term therapy, it is necessary to monitor laboratory parameters of liver function.

Symptoms of cholestatic jaundice may develop several days after the start of therapy, but the risk of development increases after 7-14 days of continuous therapy. The likelihood of developing an ototoxic effect is higher in patients with renal and hepatic insufficiency, as well as in elderly patients.

Some resistant strains of Haemophilus influenzae are sensitive to concomitant administration of erythromycin and sulfonamides.

May interfere with the determination of catecholamines in urine and the activity of hepatic transaminases in the blood (colorimetric determination using definylhydrazine).

Pregnancy and lactation

Due to the possibility of passage into breast milk, you should avoid breastfeeding while taking erythromycin.

Use in childhood

Conditions for dispensing from pharmacies

The drug is available with a prescription.

Storage conditions and periods

List B. Store in a dry place, protected from light, out of reach of children, at a temperature not exceeding 25°C.

Shelf life - 2 years. Do not use after expiration date.

A bacteriostatic antibiotic from the macrolide group, reversibly binds to the 50S subunit of ribosomes in its donor part, which disrupts the formation of peptide bonds between amino acid molecules and blocks the synthesis of microbial proteins (does not affect the synthesis of nucleic acids). When used in high doses, it can exhibit a bactericidal effect. The spectrum of action includes gram-positive (Staphylococcus spp., producing and non-producing penicillinase, including Staphylococcus aureus; Streptococcus spp. (including Streptococcus pneumoniae, Streptococcus pyogenes), alpha-hemolytic streptococcus (Viridans group), Bacillus anthracis, Corynebacterium diphtheriae, Coiynebacterium minutissimum) and gram-negative microorganisms (Neisseria gonorrhoeae, Haemophilus influenzae, Bordetella pertussis, Brucella spp., Legionella spp., including Legionella pneumophila) and other microorganisms: Mycoplasma spp. (including Mycoplasma pneumoniae), Chlamydia spp. (including Chlamydia trachomatis), Treponema spp., Rickettsia spp., Entamoeba histolytica, Listeria monocytogenes.

Gram-negative rods are resistant: Escherichia coli, Pseudomonas aeruginosa, as well as Shigella spp., Salmonella spp. and others. The sensitive group includes microorganisms whose growth is delayed at an antibiotic concentration of less than 0.5 mg/l, moderately sensitive - 1-6 mg/l, moderately resistant and resistant - 6-8 mg/l.

Pharmacokinetics

Absorption is high. Oral enteric-coated base forms of erythromycin have no effect on food intake. Cmax is achieved after oral administration in 2-4 hours. Communication with plasma proteins is 70-90%.

Bioavailability - 30-65%, unevenly distributed in the body. It accumulates in large quantities in the liver, spleen, and kidneys. In bile and urine, the concentration is tens of times higher than the concentration in plasma. Penetrates well into the tissues of the lungs, lymph nodes, middle ear exudate, prostate secretions, sperm, pleural cavity, ascitic and synovial fluid. The milk of lactating women contains 50% of the plasma concentration. It penetrates poorly through the BBB into the cerebrospinal fluid (its concentration is 10% of the drug content in plasma). During inflammatory processes in the membranes of the brain, their permeability to erythromycin increases slightly. Penetrates through the placental barrier and enters the blood of the fetus, where its content reaches 5-20% of the content in the mother's plasma.

Metabolized in the liver (more than 90%), partially with the formation of inactive metabolites. T1/2 - 1.4-2 hours, with anuria - 4-6 hours. Excretion with bile - 20-30% unchanged, by the kidneys (unchanged) after oral administration - 2-5%.

Indications

Bacterial infections caused by sensitive microflora:

Diphtheria (including bacterial carriage);

Whooping cough (including prevention);

Trachoma;

Brucellosis;

Legionnaires' disease;

Erythrasma;

Listeriosis;

Scarlet fever;

Amoebic dysentery;

Gonorrhea;

Conjunctivitis of newborns;

Pneumonia in children;

Urogenital infections in pregnant women caused by Chlamydia trachomatis;

Primary syphilis (in patients allergic to penicillins);

Uncomplicated chlamydia in adults (with localization in the lower genitourinary tract and rectum) with intolerance or ineffectiveness of tetracyclines, etc.;

Infections of the ENT organs (tonsillitis, otitis media, sinusitis);

Biliary tract infections (cholecystitis);

Infections of the upper and lower respiratory tract (tracheitis, bronchitis, pneumonia);

Infections of the skin and soft tissues (pustular skin diseases, including juvenile acne, infected wounds, bedsores, burns II - III degree, trophic ulcers);

Infections of the mucous membrane of the eyes;

Prevention of exacerbation of streptococcal infection (tonsillitis, pharyngitis) in patients with rheumatism;

Prevention of infectious complications during medical and diagnostic procedures (including preoperative bowel preparation, dental interventions, endoscopy, in patients with heart defects).

Contraindications

Hypersensitivity;

Hearing loss;

Concomitant use of terfenadine or astemizole;

Lactation period.

WITH caution: arrhythmias (history); prolongation of the QT interval; jaundice (history); liver failure; renal failure.

Use during pregnancy and breastfeeding

Due to the possibility of passage into breast milk, breastfeeding should be avoided when erythromycin is prescribed.

Use for liver dysfunction

Contraindicated in liver failure.

Use for renal impairment

Contraindicated in renal failure.

special instructions

During long-term therapy, it is necessary to monitor laboratory parameters of liver function.

Symptoms of cholestatic jaundice may develop several days after the start of therapy, but the risk of development increases after 7-14 days of continuous therapy. The likelihood of developing an ototoxic effect is higher in patients with renal and hepatic insufficiency, as well as in elderly patients.

Some resistant strains of Haemophilus influenzae are sensitive to concomitant administration of erythromycin and sulfonamides.

May interfere with the determination of catecholamines in urine and the activity of hepatic transaminases in the blood (colorimetric determination using definylhydrazine).

Overdose

Symptoms: impaired liver function, up to acute liver failure, hearing loss.

Treatment: activated carbon, careful monitoring of the respiratory system. Gastric lavage is effective when taking a dose five times higher than the average therapeutic dose. Hemodialysis, peritoneal dialysis, and forced diuresis are ineffective.

Drug interactions

Drugs that block tubular secretion prolong T1/2 of erythromycin.

Incompatible with lincomycin, clindamycin and chloramphenicol (antagonism).

Reduces the bactericidal effect of beta-lactam antibiotics (penicillins, cephalosporins, carbopenems).

When taken simultaneously with drugs that are metabolized in the liver (theophylline, carbamazepine, valproic acid, hexobarbital, phenytoin, alfentanil, disopyramide, lovastatin, bromocriptine), the concentration of these drugs in plasma may increase (it is an inhibitor of microsomal liver enzymes).

Increases the nephrotoxicity of cyclosporine (especially in patients with concomitant renal failure). Reduces the clearance of triazolam and midazolam, and therefore may enhance the pharmacological effects of benzodiazepines.

When taken simultaneously with terfenadine or astemizole - the possibility of developing arrhythmia, with dihydroergotamine or non-hydrogenated ergot alkaloids - vasoconstriction to spasm, dysesthesia.

Slows down the elimination (increases the effect) of methylprednisolone, felodipine and coumarin anticoagulants.

When co-administered with lovastatin, rhabdomyolysis increases.

Increases the bioavailability of digoxin.

Reduces the effectiveness of hormonal contraception.

Conditions for dispensing from pharmacies

The drug is available with a prescription.

Storage conditions and periods

List B. In a dry place, protected from light, out of reach of children, at a temperature not exceeding 25°C.

Shelf life: 2 years. Do not use after expiration date.

Erythromycin ointment is an inexpensive and effective remedy for acne, known to many. But its scope of application is not limited to dermatology - the ointment is popular in ophthalmology and a number of other areas of medicine.

Erythromycin ointment - description and action

Erythromycin in ointment form is an external agent with an antibacterial effect. The main active substance is an antibiotic macrolide with a wide spectrum of activity - erythromycin(there are 10,000 units of it in the product). The drug also contains a number of auxiliary components:

• sodium disulfate;
• petrolatum;
• sodium pyrosulfite;
• lanolin anhydrous.

The product is available in tubes of 5 g (eye ointment) and 10.15 g, which are packaged in cardboard boxes. It is produced by different pharmaceutical companies - “Biosintez”, “Sintez”, “Tathimfarmpreparaty”, medium the price of the largest package is 150 rubles.

The drug is non-toxic and can be used on any part of the body or face. It is tolerated by patients better than drugs based on penicillin antibiotics. Erythromycin has an antimicrobial effect - it binds to the ribosomal components of bacteria, destroys the molecular bonds of amino acids, thereby inhibiting the synthesis of microbial proteins. Erythromycin helps against diseases caused by microbes sensitive to it:

• Neisseria;
• chlamydia;
• staphylococcus;
• streptococcus;
• influenza;
• bordetella;
• Brucella;
• corynebacterium;
• clostridia.

A number of gram-negative bacilli do not respond to treatment due to resistance to the active substance (Escherichia coli, Shigella, Pseudomonas aeruginosa).

Indications for use

For eye treatment, the product is widely used even in children. It helps against a number of eye infections:

• bacterial conjunctivitis;
• inflammation of the mucous membrane of the eyes in newborns;
• bacterial blepharitis;
• microbial blepharoconjunctivitis;
• meibomite, barley.

Also in ophthalmology, the ointment is indicated in the complex therapy of chlamydial conjunctivitis, blepharitis, and keratitis. In case of trachoma, in parallel, frequent eye rinsing with antiseptics should be done. As a prophylactic agent, Erythromycin is used to prevent neonatal blenorrhea.

If used for too long, all bacteria become resistant to erythromycin - this is the drawback of the medicine.

Erythromycin can be used on the skin against various pathologies caused by microbes. The ointment is indicated for 2-3 degree burns, including before they become infected (to prevent the development of a secondary infection). The product is used to treat infected wounds, abrasions, and poorly healing cuts.

Also indicated for use are:

Instructions for use

The ointment is for external use only. Before application, thoroughly wash the affected area of ​​skin and allow it to dry. Usually the drug is gently rubbed into the skin and mucous membranes 2-3 times a day. The duration of therapy depends on the severity of the infectious process, most often it is 1-3 weeks. Under the supervision of a doctor, the ointment can be used for a longer course - up to 6-8 weeks.

This course can lead to the development of a secondary fungal infection due to the destruction of all bacterial flora, including non-pathogenic ones.

Therapy for certain types of disease is carried out as follows:

1. Conjunctivitis, blepharitis. Three times a day you should apply the product (about 0.2 g per procedure) behind the lower eyelid. To do this, you need to wash your hands thoroughly, squeeze the ointment onto your finger, and apply it to the sore area.
2. Trachoma. Erythromycin should be used in the same way, but 5 times a day.
3. Purulent wounds. Cleanse the skin of purulent-necrotic masses (in some cases, surgical treatment may be required). Apply the medicine and cover the wound with a sterile gauze bandage.
4. Burns. Apply the product 3-4 times a week until recovery.

For acne, Erythromycin is applied to the skin pointwise twice a day; if the frequency of rashes is high, the ointment can be rubbed in indiscriminately. First, the skin should be cleansed of makeup, grease, and dirt.

Contraindications, side effects

Using ointment during pregnancy can be dangerous. Even those small concentrations of the drug that enter the bloodstream when rubbed locally can penetrate the placental barrier. Therefore, in the first trimester, Erythromycin ointment is contraindicated, in the 2-3 trimesters.

During lactation, long-term use of the drug requires discontinuation of breastfeeding, since erythromycin passes into breast milk.

Severe stages of kidney and liver dysfunction (decompensated forms) are also contraindications to treatment. Other prohibitions are:

The most common side effects are redness, rashes on the body, hyperthermia, itching, and allergic reactions. In rare cases, systemic side effects are possible - headaches, dizziness, swelling, rash all over the body. Such situations require urgent discontinuation of the drug.

Analogs and other information

Analogues include a number of other antibacterial and antiseptic agents in the form of ointments, which are sold in pharmacies.

Erythromycin belongs to the class of macrolides. It is a reserve drug for the treatment of patients with penicillin intolerance, since it has a similar spectrum of activity.

The antibiotic is capable of irreversibly binding to microbial 5OS ribosomal subunits, interfering with the translocation process and disrupting peptide bonds between bacterial amino acids, exhibiting a bacteriostatic effect. It is well tolerated and has a low incidence of adverse events.

It can be effectively absorbed when taken orally, but food intake sharply reduces the rate of its absorption from the gastrointestinal tract. It is biotransformed in the liver, so when prescribed to elderly patients or patients with liver diseases, dose adjustment may be required.

Therapeutic antimicrobial concentrations are achieved within two to three hours when taking tablets, and within twenty minutes when administered intravenously.

The antibiotic must be taken either an hour to an hour and a half before meals, or two to three hours after meals.

It is forbidden to break, chew, crush and dissolve in water. They should be washed down only with clean boiled water.

In elderly patients, treatment should be carried out by monitoring the biochemical parameters of the liver. If necessary, the prescribed dosages are adjusted.

The dose is not changed in persons with impaired renal function.

Is Erythromycin ® an antibiotic or not?

Erythromycin ® is an antibiotic from the macrolide group.

Broad spectrum or not?

The drug is effective against mycoplasmas, chlamydia, ureaplasma, Treponema pallidum, Listeria and Legionella, group A beta-hemolytic streptococcus, gonococci, diphtheria bacillus, pneumococcus, Brucella and rickettsia. Not effective against most gram pathogens, mycobacteria, viruses and fungi. That is, the spectrum of activity of the drug is quite limited and it is not a broad-spectrum antibiotic.

It is also important to consider that bacteria can quickly develop resistance to the drug.

Release forms of erythromycin ®, their composition and cost

The active ingredient is erythromycin ®.

The antimicrobial agent is available in the form:

• Table 0.25 and 0.5 grams each;
• Eye ointment (1 g of solution contains 10 thousand units of erythromycin ®;
• Ointments for external use (1 solution contains 10 thousand units of erythromycin ®);
• Flak. containing 100 mg of powder for the production of inf. solution;
• Suspensions;
• Rectal suppositories.

Erythromycin ® eye drops are not produced. In ophthalmology, this antibiotic is used in the form of an eye ointment, produced by the Russian company Tatkhimfarmpreparaty ®. Price – 100 rubles.

Photo of packaging of erythromycin tablets 250 mg

The price for a package containing 10 tablets of 500 milligrams of antibiotic, produced by the Russian pharmaceutical company Sintez ®, is 90 rubles.

Antibiotic ointment costs about seventy rubles.

Tablets of 0.25 g (20 tablets) produced by Irbitsky HFZ ® - 80 rubles.

Vials of erythromycin ®, produced by the Russian Synthesis AKOMP ® - 13 rubles each.

Other forms of release

The ointment must be applied to inflamed areas of the skin two to three times a day. For burn lesions of the skin, it is used two to three times a week.

Eye ointment should be applied to the lower eyelid every eight hours. For the treatment of trachoma it is used five times a day. The duration of treatment is up to two weeks. The course for trachoma can take up to three months; when the severity of clinical symptoms decreases, the ointment is started to be used three times a day.

Prescription for erythromycin ® in Latin

Rp: Erythromycini 0.5
D.t. d. N 10 in tab.
S. 1 tablet 4 times a day.

List of indications and contraindications for the use of erythromycin ®

The antibiotic is used to treat:

• Whooping cough;
• Trachomas;
• Carriage of diphtheria bacillus;
• Syphilis;
• Gonorrhea;
• Chlamydia;
• Amoebic dysentery;
• Legionellosis;
• Scarlet fever;
• Tonsillitis;
• Pharyngitis;
• Acne and other pustular lesions of the skin;
• Biliary tract infections;
• Bronchitis and pneumonia;
• Diseases of the genitourinary system in pregnant women;

It can also be prescribed for gastroparesis, due to its ability to accelerate the evacuation of food from the stomach, increasing the amplitude of pyloric contractions and improving antral-duodenal coordination.

In the form of an ointment, it can be used for acne, boils, trophic ulcers, bedsores, burn lesions of the skin, and infected wounds.

What does erythromycin ® eye ointment help with?

Prescribed for the treatment of inflammatory eye lesions associated with macrolide-sensitive flora.

This ointment is highly effective for bacterial conjunctivitis, blepharitis and trachoma.

Can be used to treat children, pregnant and lactating women.

General contraindications to the use of erythromycin ®

Does not apply:

• for the treatment of patients with macrolide intolerance;
• in the presence of severe hearing loss;
• simultaneously with terfenadine and astemizole.

• in the last trimester of pregnancy,
• during lactation,
• in persons with severe heart rhythm disturbances and liver diseases,
• with jaundice.

Erythromycin ® dosages for adults and children

For adult patients, the standard single dose is 0.25 g. In case of severe disease or the risk of complications, 0.5 g is prescribed. The recommended daily dose is from 1 to 2 grams. Maximum – 4 grams (at one time no more than 0.5 g). The tablets are taken four times a day (every six hours). For the treatment of severe diseases, a tablet of 250-500 mg is prescribed every four hours.

The standard course of treatment is from five to 14 days. It is important to remember that the drug should not be discontinued earlier than two days after the disappearance of clinical symptoms and stabilization of the condition.

Dosage of erythromycin ® tablets for children

Babies up to three months are prescribed 20-40 milligrams of the drug per kilogram per day.

From four months, 30 to 50 mg/kg per day is prescribed. From three to six years - from 0.5 to 0.7 grams. From six to eight years – 0.7 grams. From 8 to fourteen years old, one gram per day can be prescribed. From the age of 14, adult dosages are recommended.

The daily dose is divided into four times and taken every six hours. For children, the product is used in the form of a suspension.

In dermatology, erythromycin is prescribed for the treatment of juvenile acne, 0.25 grams every 12 hours for one month. Next comes a reduction to 250 milligrams per day.

The standard for whooping cough is from 100 to two hundred mg every six hours, lasting from five to 14 days.

Basic dosage regimens for adults

To treat carriers of diphtheria bacilli, it is necessary to prescribe 0.25 grams of antibiotic twice a day.

Treatment for syphilis is carried out in courses. Their quantity depends on the form of the disease, the dosage is selected based on the patient’s weight.

If you weigh less than 60 kg, thirty grams of erythromycin should be prescribed per course of treatment.

From 60 to 80 kilos – 35 grams. Patients weighing more than eighty kilos are prescribed 40 grams per course of treatment. The duration of treatment is from 10 to 15 days.

Number of courses of antibiotic therapy:

• primary seronegative syphilis - two;
• seropositive - four;
• fresh secondary – five;
• late forms or secondary relapse – six.

For the treatment of uncomplicated forms of chlamydia, in patients with intolerance to tetracycline drugs, 0.5 grams is prescribed every six hours, for a course of seven or more (if necessary) days.

Treatment of gonorrhea is carried out at 500 milligrams four times a day for 3 days, followed by a decrease to 0.25 grams four times a day for another seven days.

Therapy for dysentery of amoebic etiology lasts from 10 to 14 days, in a daily dosage of 0.25 grams every six hours.

Legionellosis is treated within two weeks - from 0.5 grams to 1000 milligrams every six hours.

Infections of the genitourinary system in women bearing a child are treated with a course of seven or more (if necessary) days, 500 milligrams every six hours. It is possible to prescribe 0.25 grams four times a day or 0.5 grams 2 times a day for two weeks.

Therapy for pharyngitis of streptococcal etiology is carried out from twenty to fifty milligrams per kilogram per day, lasting at least 10 days.

For the treatment of gastroparesis, 150 to 250 milligrams can be prescribed half an hour before meals, three times a day.

Dosage of the drug for parenteral administration

When used parenterally, the antibiotic is prescribed intravenously (slowly) or intravenously as a dropper. For adults, the daily dose is 600 mg (single dose - 200). For severe infections, it increases to a gram per day. For babies up to three months of age, 20 to 40 milligrams per kilogram per day are prescribed. From four months to 18 years, 30 to 50 mg/kg/day is prescribed. The daily dosage should be divided into two to four administrations, depending on the severity of the disease and the prescribed dose.

For the treatment of severe infections with a high risk of complications, the daily dose can be doubled.

The course of parenteral use is five to six days, after which it is recommended to switch to the tablet form.

Side effects from the use of erythromycin ®

As a rule, it is well tolerated by patients; undesirable effects from the prescription are quite rare and, as a rule, are manifested by dyspeptic disorders, abdominal pain, diarrhea, and disturbances of the intestinal microflora of varying severity. Sometimes after a long course of antibacterial therapy, fungal infections of the mucous membranes (candidiasis of the vagina and oral cavity) are possible.

Rarely, pseudomembranous colitis, bile stagnation and jaundice, liver dysfunction, and drug-induced pancreatitis are possible.

The ototoxic effect of erythromycin occurs when the daily dosage exceeds four grams. Hearing loss is usually temporary and recovers after discontinuation of the drug.

Allergy to macrolides is extremely rare.

Heart rhythm disturbances and phlebitis at the injection site are also possible (with intravenous administration).

Compatibility of erythromycin ® with alcohol

The antibiotic is not compatible with alcoholic beverages. Erythromycin ® is metabolized in the liver, so drinking alcohol can lead to the development of intoxication and drug-induced hepatitis. Also, drinking alcohol reduces the effectiveness of antimicrobial therapy.

Erythromycin ® during pregnancy

Macrolides are included in the list of approved medications for use in women bearing a child. This group of antibiotics is low-toxic, has a small number of contraindications and restrictions for use, is not teratogenic and is well tolerated by patients.

However, erythromycin during pregnancy, prescribed in the last trimester with systemic use (tablets and parenteral administration), can lead to hypertrophic pyloric stenosis in the baby. Prescribing an antimicrobial agent topically, in the form of ointments, does not lead to such an effect.

Also, given the ability of macrolides to pass into breast milk in small doses, during breastfeeding its prescription must be agreed with the attending physician.

Erythromycin ® - drug analogues

Trade names:

• Grunamycin ® ;
• Eriderm ® ;
• Izolon ® ;
• Erigexal ® ;
• Synerit ® ;
• Erythromycin-Ratiopharm ®;
• Eomycin ® ;
• Erythromycin-Teva ®;
• Eracin ® ;
• Eric ® ;
• Adimicin ® .

Combined anti-acne products:

• Isotrexin ® .

Borshchagovsky, Russia
Conditions for dispensing from a pharmacy: Over the counter

Erythromycin ointment has been used in medicine for quite some time. It has established itself as an effective remedy with antibacterial effects. The ointment is used for external use for many eye diseases, some pathologies of the nose, as well as skin ailments, purulent wounds and burns. In addition, erythromycin ointment for acne is considered the most effective method, which is suitable for both adults and children. In addition to ointments, erythromycin-based tablets and gel are used to treat infectious pathologies, which also have a beneficial effect on the skin, helping to get rid of acne and pimples.

Medicinal properties

Erythromycin ointment, gel and tablets are among the antibiotic agents and are characterized by an increased antibacterial effect, which affects the process of protein synthesis of microorganisms. They act against infections caused by gram-positive and gram-negative bacteria, thanks to which they help fight staphylococci, streptococci, chlamydia, etc. The presence of anti-inflammatory properties in the ointment and gel makes it possible to use erythromycin in the treatment of acne and skin rashes. Tablets cope well with bacterial infections caused by the above microorganisms. When using erythromycin, the main component accumulates in the kidneys and liver and is excreted in the bile and kidneys.

Erythromycin ointment

The ointment is prescribed for the following indications:

• Eye diseases: conjunctivitis, including in newborns, bacterial blepharitis, keratitis, stye, chlamydia, etc.
• Purulent and trophic wounds, burns
• Infectious skin diseases.

Average price: 40 rub.

Erythromycin for acne is prescribed as often as in gynecology. Due to its antibacterial effect in gynecology, the ointment is used externally as an additional remedy against inflammatory female diseases, such as vulvitis. Erythromycin ointment has an effective effect on inflammation of the nasal mucosa.

The active component of the ointment is erythromycin 1000 units. Excipients: anhydrous lanolin, sodium disulfide and special petroleum jelly.

The ointment has a yellowish tint and a specific odor. Produced in aluminum tubes of 3, 7, 10 or 15 grams, can also be offered in a 30 g can.

Directions for use and doses

For eye diseases, at the beginning of the treatment course, the ointment is applied to the lower part 3 times a day. Then, as inflammation decreases, they switch to a regimen of 1-2 times a day. The therapeutic course is 2 weeks. The ointment for trachoma is applied to the eyelid 5 times a day, the duration of treatment can be about 3 months.

Skin diseases and purulent wounds are treated with ointment, applying it to the affected part of the body 2 times a day in a thin layer. When treating purulent wounds, the drug draws out suppuration well and promotes their healing. Treatment lasts no more than 14 days.

For burns, the ointment is used externally, 2-3 times a week, for 1-2 months.

Erythromycin ointment for acne is applied to the affected areas 2-3 times a day, the duration of therapy depends on the condition of the skin.

For inflammation of the nasal mucosa, the ointment is applied to the nose 2-3 times a day, the duration of the course is determined by the doctor.

Erythromycin gel

Price: 35 rub.

The gel mainly finds use in treating pimples and blackheads.

The main active ingredient in the gel is erythromycin, with the addition of zinc acetate.

Erythromycin-based gel comes with the addition of additional ingredients. The gel, in addition to erythromycin, contains zinc acetate, which is transparent in appearance. Sold in tubes enclosed in a cardboard box, along with attached instructions.

Directions for use and doses

The gel is mainly used against acne and blackheads, applying a thin layer to the skin 1-2 times a day. The treatment course is from 12 to 16 weeks.

Erythromycin tablets

The use of erythromycin tablets is indicated for: infections of the skin, respiratory and biliary tract, genitourinary infectious diseases.

Price: 50 rub.

The tablets contain erythromycin; povidone, crospovidone, calcium stearate, talc, and potato starch are used as additives.

The tablets are produced in a special coating, round in shape, and white in color. The pharmacy dispenses 10 and 20 tablets in blister packs placed in cardboard packages.

Directions for use and doses

For adults and children over 14 years of age, erythromycin tablets are prescribed 250 mg 4-6 times a day 1 hour before meals. For complicated pathologies, the dosage may be increased. The daily dose should not exceed 4 g. Children under 3 months are prescribed a dose of 20-40 mg/kg, from this age up to 18 years - 30-50 mg/kg. The duration depends on the course of the disease; generally, treatment lasts from 5 to 14 days.

Tablets should not be taken with milk or dairy products!

Contraindications and precautions

It is prohibited to use ointment, gel and tablets for the following indications:

• Severe liver pathologists
• Increased susceptibility to the leading substance
• Serious renal dysfunction.

The ointment and gel should be used with extreme caution during pregnancy and nursing mothers; tablets should not be prescribed during this period. In addition, therapy for infants is carried out strictly under the supervision of a doctor.

Before starting treatment with these medications, it is recommended to test for an allergic reaction.

If erythromycin ointment or gel is used against acne, then the use of any other product within an hour is prohibited.

When using medications, you are allowed to drive vehicles and other mechanisms that require special attention and concentration.

When using tablets for a long time, you should monitor your blood counts.

During pregnancy and breastfeeding

The effects of ointment and gel during pregnancy and breastfeeding have not been fully studied, so experts recommend avoiding their use at this time. The use of tablets is also prohibited for pregnant women.

Cross-drug interactions

The medication cannot be combined with lincomycin and clindamycin.

Erythromycin ointment tends to reduce the effectiveness of penicillins, cephalosporins, and carbopenems.

Parallel external use with abrasive agents dries and irritates the skin.

Side effects

Among the adverse reactions, cases of allergies were recorded, in the form of redness and itching of the skin. With prolonged use, secondary development of infection is possible. You can learn how to cope with itching in the article: treating itching.

Overdose

Information about exceeding the dose of the drug is not known today.

Conditions and shelf life

The ointment and gel must be stored in a place protected from children for no more than 3 years.

The tablets are stored at room temperature, shelf life is 2 years.

Phloxal

Dr. Gerhard Mann. Germany
Price from 150 to 250 rubles

Floxal is an antimicrobial medication belonging to the group of fluorochlorides. Used externally in the treatment of eye diseases caused by an infectious-inflammatory process. Also, in some cases, for a runny nose, medicine is instilled into the nose. The active ingredient is ofloxacin. It is produced in the form of eye drops and ointments, but is not available in tablet form.

Pros:

• A quick effect is achieved
• Can be used by children
• The eye drops do not sting.

Minuses:

• Fairly high cost
• Short shelf life.

Azithromycin

Vertex, Russia
Price from 40 to 190 rubles

Azithromycin is a modern antibiotic, part of the macrolites group, with a wide range of action. Used for many diseases caused by infection. Most often, Azithromycin is prescribed for infectious pathologies of the respiratory tract, skin ailments, pathologies of the genitourinary system, infections, diseases of the nose and throat. Recommended Azithromycin in the form of tablets and capsules, used for oral administration.

Pros:

• High efficiency
• Affordable price
• Convenient scheme of use.

Minuses:

• Many adverse reactions
• Children under 12 years old are prohibited.

Download instructions for use

In this article you can read the instructions for use of the drug Erythromycin. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Erythromycin in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Erythromycin in the presence of existing structural analogues. Use for the treatment of sore throat, acne (pimples) in adults, children, as well as during pregnancy and breastfeeding.

Erythromycin- a bacteriostatic antibiotic from the group of macrolides, reversibly binds to the 50S subunit of ribosomes in its donor part, which disrupts the formation of peptide bonds between amino acid molecules and blocks the synthesis of microbial proteins (does not affect the synthesis of nucleic acids). When used in high doses, it can exhibit a bactericidal effect.

The spectrum of action includes gram-positive and gram-negative microorganisms, as well as other microorganisms: Mycoplasma spp. (including Mycoplasma pneumoniae), Chlamydia spp. (including Chlamydia trachomatis), Treponema spp., Rickettsia spp., Entamoeba histolytica, Listeria monocytogenes.

Gram-negative rods are resistant: Escherichia coli, Pseudomonas aeruginosa, as well as Shigella spp., Salmonella spp. and others. The sensitive group includes microorganisms whose growth is delayed at an antibiotic concentration of less than 0.5 mg/l, moderately sensitive - 1-6 mg/l, moderately resistant and resistant - 6-8 mg/l.

Pharmacokinetics

Absorption is high. Oral enteric-coated base forms of erythromycin have no effect on food intake.

It is distributed unevenly in the body. It accumulates in large quantities in the liver, spleen, and kidneys. In bile and urine, the concentration is tens of times higher than the concentration in plasma. Penetrates well into the tissues of the lungs, lymph nodes, middle ear exudate, prostate secretions, sperm, pleural cavity, ascitic and synovial fluid. The milk of lactating women contains 50% of the plasma concentration. It penetrates poorly through the blood-brain barrier into the cerebrospinal fluid (its concentration is 10% of the drug content in plasma). During inflammatory processes in the membranes of the brain, their permeability to erythromycin increases slightly. Penetrates through the placental barrier and enters the blood of the fetus, where its content reaches 5-20% of the content in the mother's plasma.

Excretion with bile - 20-30% unchanged, by the kidneys (unchanged) after oral administration - 2-5%.

Indications

Bacterial infections caused by sensitive microflora:

• diphtheria (including bacterial carriage);
• whooping cough (including prevention);
• trachoma;
• brucellosis;
• Legionnaires' disease (legionellosis);
• erythrasma;
• listeriosis;
• scarlet fever;
• amoebic dysentery;
• gonorrhea;
• conjunctivitis of newborns;
• pneumonia in children;
• genitourinary infections in pregnant women caused by Chlamydia trachomatis;
• primary syphilis (in patients allergic to penicillins);
• uncomplicated chlamydia in adults (with localization in the lower genitourinary tract and rectum) with intolerance or ineffectiveness of tetracyclines;
• infections of the ENT organs (tonsillitis, otitis media, sinusitis);
• biliary tract infections (cholecystitis);
• infections of the upper and lower respiratory tract (tracheitis, bronchitis, pneumonia);
• infections of the skin and soft tissues (pustular skin diseases, including juvenile acne, infected wounds, bedsores, II-III degree burns, trophic ulcers);
• infections of the mucous membrane of the eyes;
• prevention of exacerbations of streptococcal infections (tonsillitis, pharyngitis) in patients with rheumatism;
• prevention of infectious complications during medical and diagnostic procedures (including preoperative bowel preparation, dental interventions, endoscopy, in patients with heart defects).

Release forms

Enteric-soluble film-coated tablets 100 mg, 250 mg and 500 mg.

Eye ointment.

Ointment for local and external use (sometimes mistakenly called gel).

Lyophilisate for the preparation of solution for intravenous administration (in vials for injection).

Instructions for use and dosage

Pills

A single dose for adults and adolescents over 14 years of age is 250-500 mg, daily - 1-2 g. The interval between doses is 6 hours. For severe infections, the daily dose can be increased to 4 g.

Children from 4 months to 18 years, depending on age, body weight and severity of infection - 30-50 mg/kg per day in 2-4 doses; children of the first 3 months. life - 20-40 mg/kg per day. For more severe infections, the dose may be doubled.

For the treatment of diphtheria carriage - 250 mg 2 times a day. The course dose for the treatment of primary syphilis is 30-40 g, the duration of treatment is 10-15 days.

For amoebic dysentery, adults - 250 mg 4 times a day, children - 30-50 mg/kg per day; Course duration is 10-14 days.

For legionellosis - 500 mg-1 g 4 times a day for 14 days.

For gonorrhea - 500 mg every 6 hours for 3 days, then 250 mg every 6 hours for 7 days.

For preoperative bowel preparation to prevent infectious complications - orally, 1 g 19 hours, 18 hours and 9 hours before surgery (3 g in total).

For the prevention of streptococcal infections (for tonsillitis, pharyngitis) adults - 20-50 mg/kg per day, children - 20-30 mg/kg per day, course duration - at least 10 days.

For the prevention of septic endocarditis in patients with heart defects - 1 g for adults and 20 mg/kg for children, 1 hour before a treatment or diagnostic procedure, then 500 mg for adults and 10 mg/kg for children, again in 6 hours

For whooping cough - 40-50 mg/kg per day for 5-14 days. For pneumonia in children - 50 mg/kg per day in 4 divided doses for at least 3 weeks. For genitourinary infections during pregnancy - 500 mg 4 times a day for at least 7 days or (if this dose is poorly tolerated) - 250 mg 4 times a day for at least 14 days.

In adults, with uncomplicated chlamydia and intolerance to tetracyclines - 500 mg 4 times a day for at least 7 days.

They are set individually depending on the location and severity of the infection and the sensitivity of the pathogen. In adults, a daily dose of 1-4 g is used. Children under 3 months of age - 20-40 mg/kg per day; at the age of 4 months to 18 years - 30-50 mg/kg per day. Frequency of application - 4 times a day. The course of treatment is 5-14 days, after the symptoms disappear, treatment is continued for another 2 days. Take 1 hour before meals or 2-3 hours after meals.

Apply the solution for external use to the affected areas of the skin.

The ointment is applied to the affected area, and in case of eye diseases, it is placed behind the lower eyelid. The dose, frequency and duration of use are determined individually.

Side effect

• allergic skin reactions (urticaria, other forms of rash);
• eosinophilia;
• anaphylactic shock;
• nausea, vomiting;
• gastralgia;
• tenesmus;
• abdominal pain;
• diarrhea;
• dysbacteriosis;
• oral candidiasis;
• pseudomembranous enterocolitis (both during and after treatment);
• hearing loss and/or tinnitus (when using high doses - more than 4 g/day, hearing loss after discontinuation of the drug is usually reversible);
• tachycardia;
• prolongation of the QT interval on the ECG;
• ventricular arrhythmias, including ventricular tachycardia (pirouette type) in patients with a prolonged QT interval.

Contraindications

• hypersensitivity;
• hearing loss;
• simultaneous use of terfenadine or astemizole;
• lactation period.

Use during pregnancy and breastfeeding

Due to the possibility of passage into breast milk, you should avoid breastfeeding while taking erythromycin.

special instructions

During long-term therapy, it is necessary to monitor laboratory parameters of liver function.

Symptoms of cholestatic jaundice may develop several days after the start of therapy, but the risk of development increases after 7-14 days of continuous therapy. The likelihood of developing an ototoxic effect is higher in patients with renal and hepatic insufficiency, as well as in elderly patients.

Some resistant strains of Haemophilus influenzae are sensitive to concomitant administration of erythromycin and sulfonamides.

May interfere with the determination of catecholamines in urine and the activity of hepatic transaminases in the blood (colorimetric determination using definylhydrazine).

Drug interactions

Incompatible with lincomycin, clindamycin and chloramphenicol (antagonism).

Reduces the bactericidal effect of beta-lactam antibiotics (penicillins, cephalosporins, carbopenems).

When taken simultaneously with drugs that are metabolized in the liver (theophylline, carbamazepine, valproic acid, hexobarbital, phenytoin, alfentanil, disopyramide, lovastatin, bromocriptine), the concentration of these drugs in plasma may increase (it is an inhibitor of microsomal liver enzymes).

Increases the nephrotoxicity of cyclosporine (especially in patients with concomitant renal failure). Reduces the clearance of triazolam and midazolam, and therefore may enhance the pharmacological effects of benzodiazepines.

When taken simultaneously with terfenadine or astemizole - the possibility of developing arrhythmia, with dihydroergotamine or non-hydrogenated ergot alkaloids - vasoconstriction to spasm, dysesthesia.

Slows down the elimination (increases the effect) of methylprednisolone, felodipine and coumarin anticoagulants.

When taken together with lovastatin, rhabdomyolysis increases.

Increases the bioavailability of digoxin.

Reduces the effectiveness of hormonal contraception.

Analogues of the drug Erythromycin

Structural analogues of the active substance:

• Grunamycin syrup;
• Ilozon;
• Erythromycin-AKOS;
• Erythromycin-LecT;
• Erythromycin-Ferein;
• Erythromycin phosphate;
• Erifluid;
• Ermiced.

If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps and look at the available analogues for the therapeutic effect.

Antibacterial agents

Erythromycin is an antibiotic of the macrolide class, first obtained in 1952. It is available in the form of ointments and tablets. It is sold without a doctor's prescription because the drug is relatively safe. For the same reason, it can even be used for infants. The cream contains the active component erythromycin, as well as auxiliary ingredients in the form of lanolin, petroleum jelly and sodium sulfate solution.

1 Properties of the drug

Ointment for external use is effective against staphylococcus, corynebacteria, streptococci, salmonella, listeria, microbacteria, chlamydia, gonococci, gonorrhea and hemophilus influenzae, brucella, legionella. In addition to the antibacterial effect, which consists in blocking the synthesis of proteins of microorganisms, it has an anti-inflammatory effect. The ointment fights infected areas of the skin from the outside, while the tablets fight from the inside. Bacteria can acquire resistance (resistance) to the active ingredient, so you should not use the drug for a long time. If there is no improvement, you need to change the product to another.

Indications for use of the drug are:

• eye lesions of a bacterial and inflammatory nature (conjunctivitis, blepharitis, blepharoconjunctivitis, barley (hordeolum), keratitis, ophthalmia, chlamydia, trachoma);
• infectious lesions of the skin (rashes, pimples, acne);
• bedsores;
• infectious diseases (whooping cough, salmonella food poisoning, gonococcal and chlamydial infections);
• inflammation of the mucous membrane in the nasal cavity;
• purulent infections;
• wounds;
• burns of II and III degrees;
• inflammatory diseases of a gynecological nature (vulvitis).

Hormonal ointments for the treatment of skin diseases

2 Method of administration and dosage

If the ointment is used as a treatment for infectious and inflammatory eye lesions, the product is applied to the lower eyelid. Course - 3 times a day for conjunctivitis, blepharitis, stye. For trachoma, eye ointment is applied about 5 times. For this disease, it is allowed to use the drug for up to 3 months; the duration of therapy for other diseases depends on the severity of the disease, but it should not exceed more than 14 days. According to the general rule, if there is improvement after 2 weeks, the ointment is stopped, after which, in agreement with the doctor, it is possible to undergo a course of prophylaxis after some time. In this case, the drug is used once every 2 days for 2 weeks.

If erythromycin ointment is used against acne, the product should be used 1-2 times a day, the course duration is about 12-14 days. It is important to complete the treatment. Apply the ointment to cleansed facial skin, after moisturizing it.

For purulent diseases of the epidermis and soft tissues, the affected area is treated with a thin layer. The course is 1-2 times a day after removing dead cells and pus. For burns, it is necessary to apply the ointment 2-3 times a day for 7 days. The duration of treatment may depend on the severity of the disease. It should not exceed more than 2 weeks so that bacteria do not develop resistance to the active substance.

If erythromycin ointment is applied to the nose, then in this case it is used 2-3 times a day. According to the instructions for use, the same amount is necessary for the treatment of trophic ulcers.

Some features of the drug:

• if discomfort in the form of itching appears after applying the ointment, you should discontinue treatment with erythromycin, rinse it off with water, and consult a specialist;
• the product must be applied in a thin layer;
• despite the drug being sold without a prescription, it is necessary to consult a doctor before using it to determine the exact dosage and duration of therapy;
• if the ointment does not help and the skin condition does not improve within 3-4 weeks, you need to visit a specialist (sometimes it takes 2-3 months to completely cure acne);
• Do not use the product for too long, as superinfection may form;
• if the ointment is used as a medicine against acne and pimples, it should not be combined with other medications for an hour (the high effectiveness of erythromycin together with zinc ointment in the treatment of rashes has been noted);
• the drug does not affect concentration and driving.

3 Contraindications and side effects. Analogs

Contraindications to the use of the drug are individual intolerance to the components of the drug, the period of breastfeeding, severe diseases of the internal organs (liver and kidneys).

Side effects include the following:

• itching, redness, peeling in the area where the ointment is applied;
• rashes;
• increased body temperature;
• dizziness.

To use the drug during pregnancy and breastfeeding, you need to consult a specialist. The drug is relatively safe and is used for newborns, but its full effect on the body of the mother and fetus has not been studied. During lactation, during treatment, the possibility of stopping breastfeeding and switching to artificial formula should be allowed.

The ointment is incompatible with chloramphenicol, lincomycin and clindamycin. It should not be used together with cephalosporins, carbopenems and penicillins. When used with abrasive products (scrubs, badyagi), the ointment can irritate and dry out the skin.

There are analogues of the drug:

• erythromycin phosphate;
• Ilozon;
• Ermiced;
• Grunamycin (syrup);
• Erifluid;
• Erythromycin-LecT.

Medicines with different compositions have similar properties:

• Phloxal (drops and ointment);
• Azithromycin (tablets);
• Erythromycin-Ferein (ointment);
• Erythromycin-AKOS (ointment);
• Dalatsin (capsules, solution);
• Clindatop (gel);
• Duak (gel);
• Zenerit (cream);
• Nadoxin (cream);
• Ugricil (gel).

• Composition of erythromycin ointment
• Erythromycin for acne - reviews on the Internet

Erythromycin ointment for external use can effectively fight various infections that appear not only on the skin, but also in the corners of the eyes. In order to understand how to use it correctly and what erythromycin ointment helps with, you need to know exactly the composition, instructions for use and side effects. Let's look at each of these questions.

Composition of erythromycin ointment

As may be clear from the name itself, the main component in the composition is the element erythromycin. In itself, it is an antibiotic that allows you to effectively treat the emerging disease.

Erythromycin skin ointment only partially consists of this active substance.

1 gram of the drug you purchased contains 10,000 units of erythromycin. The remaining portion of the product is filled with an anhydrous lanolin composition; 40% of the composition contains petroleum jelly and a solution of sodium sulfate salts. In terms of color, eye ointment for acne will be light yellow in color, and for skin it will have a brownish-yellow color.

Erythromycin ointment, the image of which is presented above, belongs to the bacteriostatic type of antibiotics. Moreover, doctors classify it as a macrolide. The action of the drug occurs in 2 stages:

• when entering the human body, the main active element reacts with peptide bonds between complexes of amino acid molecules;
• after 2-3 hours the body stops producing proteins in microorganisms;
• at the last stage, the infection begins to disappear due to the bactericidal effect of the drug.

At the same time, erythromycin eye ointment for acne allows you to get rid of:

• staphylococci,
• streptococci,
• brucella,
• hemophilus influenzae,
• legionella and other infectious types of bacteria.

Attention! With an increase in the daily dose of the drug, side effects may occur in the form of itching and redness of the skin.

Contraindications when using the drug

The main contraindications are related to the patient's individual intolerance or high sensitivity to specific substances in the drug. These include:

1. Presence of itching at the places where the cream was applied.
2. Appearance of redness.
3. Rashes on the body.
4. The temperature is rising.
5. Slight dizziness.

In addition, this drug is not prescribed to people who have liver disease, as well as for treatment during periods of breastfeeding and pregnancy.

Does erythromycin ointment help with acne?

Erythromycin can be produced for the treatment of infections not only in the form of an ointment, but also in gel and tablets. In any composition, these antibiotic agents will have an increased antibacterial effect, allowing them to directly influence the process of protein synthesis in infectious sites. What is the best treatment for erythromycin ointment?

Due to the anti-inflammatory effect of drugs, erythromycin is most often prescribed by doctors to treat skin rashes and acne. At the same time, what erythromycin tablets help best with is bacterial infections inside the body. Gel and ointment fight infected areas of the skin from the outside. Let's look at what erythromycin ointment and tablets are used for in each specific case.

What is erythromycin ointment used for?

Gel solutions are prescribed mainly for the following indications:

• The occurrence of eye diseases, which include conjunctivitis (used even when the disease is detected in newborns), bacterial blepharitis, the appearance of keratitis and barley.
• The patient has purulent and trophic wounds and a large number of burns throughout the body.
• The presence of an infectious skin disease.
• The appearance of acne all over the face or a separate area of ​​the body.

Erythromycin also helps with diseases in the field of gynecology as one of the additional means against the development of inflammatory female disease. An example is vulvitis.

The main active ingredient in the drug is erythromycin with an identifier of 1000 units. It is this that gives the product its yellow color and specific smell. It is supplied in special tubes made of aluminum material. The pharmacy sells tubes weighing between 3-15 grams.

Erythromycin ointment - instructions for use, price and doses

• If an eye disease occurs, treatment takes place in 3 stages:

• The beginning of the treatment course will be marked by applying the drug to the lower part of the eyelid for a week 3 times a day.
• After 2 weeks, provided that inflammation in the eye decreases, you can switch to a regimen using 1-2 times a day.
• When curing the disease, it is necessary to undergo a therapeutic course of treatment - the drug must be applied once every 2 days for 2 weeks.

• If you are using erythromycin to fight purulent wounds or any other skin diseases, then the drug should be applied to the affected areas of the body for 14 days, 2 times in a net. The most important thing is to apply the product in a thin layer so that it draws out suppuration and does not create an environment for bacteria to multiply.
• Erythromycin ointment for acne is applied 2-3 times a day. To get a quick effect, apply the drug to the affected area and do not touch for 20-25 minutes. The total duration of therapy will depend on the current condition of your skin.

Erythromycin ointment for acne in gel form - how to use and how much to apply

The gel is most often used to treat a patient with a large number of pimples or blackheads. As in the ointment, the main effect of the ingredients is associated with the presence of erythromycin in the composition, but a solution of zinc acetate acts as a cleansing element here in addition.

The gel is sold at the pharmacy in small tubes of 20-30 ml, which are placed in a white box made of paper cardboard, along with the attached instructions.

How to use the gel and in what doses?

Erythromycin gel must be placed on the skin carefully and always very thinly. The procedure should be repeated 1-2 times a day, while the course of treatment is reduced to 12-15 weeks.

Important! Erythromycin for acne can be used in both gel and ointment form. However, the first option is much better, since it contains substances that cleanse the skin. The second option is more suitable for treating burns and eye diseases.

Erythromycin tablets for acne - how are they produced and in what doses should they be used?

Erythromycin tablets should be used not only when acne appears, but also when a respiratory tract infection occurs, as well as a genitourinary infection.

The main chemically active element is erythromycin, here it is combined with the elements of povidone and crospovidone. Additionally, to impart disinfectant properties to the drug, calcium stearate and a solution of talc with potato starch are used.

The tablets are made in round form with a special white shell. A pharmacy can give you sets of 10-20 tablets in a special cell package without a doctor’s prescription.

Instructions for using tablets for acne

The dosage of the drug depends on the age of the patient and the complexity of the disease itself.

• At the mild stage of acne, adults and children over 14 years of age can take 2 tablets of 125 mg 3-5 times a day.

• If a complicated pathology occurs, the dosage is increased, but you should not take more than 4 g of tablets per day.
• If you are struggling with inflammation in children under 3 months, then doctors here advise drinking a quarter of a tablet 2 times a day.

Important! You should take the tablets exactly one hour before your intended meal.

The length of time you take the medications will depend on the further course of your illness. On average, treatment with erythromycin anti-acne tablets lasts 5 days to 2 weeks.

Attention! The most important thing is not to take the tablets with milk or any other dairy product!

Do not forget that before purchasing ointments or tablets, you must visit a specialist who:

• Compares all possible side effects and risks,
• Select a specific type of drug,
• Determines the duration and correctness of the course of treatment,
• Choose a dosage appropriate to your age and severity of the disease.

Remember that any self-medication is dangerous and will have a bad effect on your health! Be sure to consult with your doctor!