Pentalgin for joint pain. Pentalgin - instructions for use, analogs, reviews and release forms (tablets N, ICN, Plus, green without codeine and without a prescription) medications for the treatment of headache, toothache and other pain and fever in adults, children and when taking

A combined antispasmodic and anti-inflammatory drug is Pentalgin. The instructions for use explain that the drug is prescribed for pain of various etiologies, for fever during colds. Pentalgin also helps with migraines, toothache, and feverish conditions.

pharmachologic effect

The medicine Pentalgin, the instructions for use say this, has antipyretic, analgesic, antispasmodic, and anti-inflammatory effects. The therapeutic effect of the drug is due to the properties of the active components that make up Pentalgin:

• Naproxen belongs to the group of non-steroidal anti-inflammatory drugs and has analgesic, anti-inflammatory and pronounced antipyretic effects, which are associated with the normalization of prostaglandin synthesis.
• Drotaverine affects the smooth muscles of the biliary tract, gastrointestinal tract, blood vessels and genitourinary system.
• Paracetamol has analgesic and antipyretic properties, which is due to the blockade of COX in the central nervous system and the inhibitory effect on the centers of thermoregulation and pain.
• Caffeine, which is part of Pentalgin, tones the blood vessels of the brain, causes dilation of the blood vessels of the heart, skeletal muscles and kidneys, and helps eliminate drowsiness. As a psychostimulant, caffeine increases the bioavailability of non-narcotic analgesics and increases the permeability of histohematological barriers, which enhances the therapeutic effect.
• Pheniramine has a mild sedative and antispasmodic effect and enhances the analgesic effect of the active components of paracetamol and naproxen.

Since some active components penetrate the placental barrier, it is not recommended to use Pentalgin during pregnancy.

Release form and composition

Pentalgin is produced in the form of tablets, which are covered with a green film coating, 2, 6, 10 and 12 pieces in a cell package, 1-2 in a pack. The capsule contains active ingredients: paracetamol, caffeine, naproxen, pheniramine maleate and drotaverine hydrochloride. Additional ingredients: microcrystalline cellulose, croscarmellose sodium, potato starch, hyprolose, citric acid, butylated hydroxytoluene, titanium dioxide, magnesium stearate, talc, indigo carmine, hypromellose, povidone, polysorbate 80, dyes.

Pentalgin tablets: what does the medicine help with?

Main indications for use:

• various types of pain syndromes, for example, radiculitis, joint, muscle pain, during menstruation, neuralgia, algodismenorrhea;
• pain due to spasm of smooth muscles caused by chronic cholecystitis, cholelithiasis, renal colic, postcholecystectomy syndrome;
• post-traumatic and postoperative pain, including with inflammatory phenomena;
• colds with fever.

The drug is also used as a cure for toothache and migraines.

Pentalgin: instructions for use

According to the instructions, Pentalgin is taken orally, one tablet at a time. The maximum daily dose should not exceed 4 tablets. The duration of use of Pentalgin depends on the symptoms:

• As an analgesic, Pentalgin, which helps with pain, is taken for up to five days according to the instructions.
• As an antipyretic drug, the drug should not be taken for more than three days. If there is no improvement during this time, it is recommended to consult a doctor to clarify the diagnosis.

The possibility of longer-term use of Pentalgin should be discussed with your doctor. In cases where Pentalgin is prescribed during pregnancy, the drug should be taken as soon as possible.

Contraindications

According to the instructions, Pentalgin has a wide range of contraindications, namely:

• Severe renal failure.
• Severe liver failure.
• Hypersensitivity to the components of Pentalgin, from which these tablets can cause allergies.
• Condition after coronary artery bypass surgery.
• Inhibition of bone marrow hematopoiesis.
• Erosive and ulcerative lesions of the gastrointestinal tract in the acute phase.
• Frequent ventricular extrasystole.
• Severe organic diseases of the cardiovascular system, including acute myocardial infarction.
• Hyperkalemia.
• Age up to 18 years.
• Paroxysmal tachycardia.
• Severe arterial hypertension.
• A combination of bronchial asthma, recurrent nasal polyposis and paranasal sinuses due to intolerance to acetylsalicylic acid or other non-steroidal drugs.

• Kidney and liver failure of mild or moderate severity.
• Tendency to seizures.
• Cerebrovascular diseases.
• Viral hepatitis.
• History of ulcerative lesions of the gastrointestinal tract.
• Peripheral arterial diseases.
• Glucose-6-phosphate dehydrogenase deficiency.
• Epilepsy.
• Benign hyperbilirubinemia, including Gilbert, Dubin-Johnson and Rotor syndromes.
• Alcoholic liver damage.
• Diabetes mellitus.

Side effects

When treated with Pentalgin, undesirable effects may develop, for example, allergic reactions, disturbances in the nervous, cardiovascular, digestive, genitourinary and hematopoietic systems, as well as sensory organs. This may be accompanied by symptoms such as:

• tremor, headache, sleep problems;
• abnormalities in kidney function;
• dizziness, irregular heartbeat, arrhythmia;
• hearing loss;
• nausea, vomiting, constipation;
• itching, skin rash, urticaria;
• increased blood pressure, pain, erosive and ulcerative disorders of the gastrointestinal tract;
• agranulocytosis, leukopenia, anemia;
• methemoglobinemia, agitation, anxiety;
• angioedema, thrombocytopenia.

Overdose

Do not exceed the doses of Pentalgin indicated in the instructions to avoid overdose, which manifests itself as:

• Increased body temperature.
• Headache.
• Tachycardia.
• Tremors or muscle twitching.
• Increased prothrombin time.
• Gastrointestinal bleeding.
• Increased activity of liver transaminases.
• Paleness of the skin.
• Confusion.
• Lack of appetite.
• Arrhythmia.
• Frequent urination.
• Motor restlessness.
• Excitation.
• Hepatonecrosis.
• Epileptic seizures.
• Nausea, abdominal pain, vomiting.

Symptoms of liver dysfunction may not appear immediately, but 12-48 hours after an overdose. Large doses of Pentalgin can lead to coma, liver failure with progressive encephalopathy, arrhythmia, pancreatitis and death.

Interaction

Long-term combination of Pentalgin with barbiturates, rifampicin, tricyclic antidepressants and ethanol should be avoided to avoid the development of hepatotoxicity.

The simultaneous use of Pentalgin with caffeine-containing drinks and other drugs that stimulate the central nervous system can lead to its overstimulation.

Analogues of the drug Pentalgin

The main analogues are represented by drugs:

• Ibuprofen.
• Paracetamol.
• Pentalgin FS.
• Pentalgin Plus.
• Cardiomagnyl.
• Amizon.
• Analgin.

A combined antispasmodic and anti-inflammatory drug is Pentalgin. Instructions for use prescribe taking these tablets for migraines, toothaches, and feverish conditions. The drug is prescribed for pain of various etiologies, for fever during colds. What else is Pentalgin prescribed for?

Pentalgin is produced in the form of tablets, which are covered with a green film coating, 2, 6, 10 and 12 pieces in a cell package, 1-2 in a pack. The capsule contains active ingredients: paracetamol, caffeine, naproxen, pheniramine maleate and drotaverine hydrochloride.

Additional ingredients: microcrystalline cellulose, croscarmellose sodium, potato starch, hyprolose, citric acid, butylated hydroxytoluene, titanium dioxide, magnesium stearate, talc, indigo carmine, hypromellose, povidone, polysorbate 80, dyes.

The box with the drug contains instructions for use with a description.

pharmachologic effect

Pentalgin has antipyretic, analgesic, antispasmodic, and anti-inflammatory effects. The therapeutic effect of the drug is due to the properties of the active components that make up Pentalgin:

• Naproxen belongs to the group of non-steroidal anti-inflammatory drugs and has analgesic, anti-inflammatory and pronounced antipyretic effects, which are associated with the normalization of prostaglandin synthesis;
• Drotaverine affects the smooth muscles of the biliary tract, gastrointestinal tract, blood vessels and genitourinary system;
• Paracetamol has analgesic and antipyretic properties, which is due to the blockade of COX in the central nervous system and the inhibitory effect on the centers of thermoregulation and pain;
• Caffeine, which is part of Pentalgin, tones the blood vessels of the brain, causes dilation of the blood vessels of the heart, skeletal muscles and kidneys, and helps eliminate drowsiness. As a psychostimulant, caffeine increases the bioavailability of non-narcotic analgesics and increases the permeability of histohematic barriers, which enhances the therapeutic effect;
• Pheniramine has a mild sedative and antispasmodic effect and enhances the analgesic effect of the active components of paracetamol and naproxen.

Since some active components penetrate the placental barrier, it is not recommended to use Pentalgin during pregnancy.

What does Pentalgin help with?

Main indications for use:

• various types of pain syndromes, for example, radiculitis, joint, muscle pain, during menstruation, neuralgia, algodismenorrhea;
• pain due to spasm of smooth muscles caused by chronic cholecystitis, cholelithiasis, renal colic, postcholecystectomy syndrome;
• post-traumatic and postoperative pain, including with inflammatory phenomena;
• colds with fever.

The drug is also used as a cure for toothache and migraines.

Medical instructions for use of Pentalgin

According to the instructions, Pentalgin is taken orally, one tablet at a time. The maximum daily dose should not exceed 4 tablets. The duration of use of Pentalgin depends on the symptoms:

• • • As an analgesic, Pentalgin, which helps with pain, is taken for up to five days according to the instructions;
    • As an antipyretic drug, the drug should not be taken for more than three days. If there is no improvement during this time, it is recommended to consult a doctor to clarify the diagnosis.

The possibility of longer-term use of Pentalgin should be discussed with your doctor. In cases where Pentalgin is prescribed during pregnancy, the drug should be taken as soon as possible.

Do not exceed the doses of Pentalgin indicated in the instructions to avoid overdose, which manifests itself as:

• • • Lack of appetite;
    • Motor restlessness;
    • Tachycardia;
    • Frequent urination;
    • Increased activity of liver transaminases;
    • Headache;
    • Increased prothrombin time;
    • Paleness of the skin;
    • Nausea, abdominal pain, vomiting;
    • Excitation;
    • Confusion;
    • Tremors or muscle twitching;
    • Arrhythmia;
    • Increased body temperature;
    • Epileptic seizures;
    • Hepatonecrosis.

Symptoms of liver dysfunction may not appear immediately, but 12-48 hours after an overdose. Large doses of Pentalgin can lead to coma, liver failure with progressive encephalopathy, arrhythmia, pancreatitis and death.

Long-term combination of Pentalgin with barbiturates, rifampicin, tricyclic antidepressants and ethanol should be avoided to avoid the development of hepatotoxicity.

The simultaneous use of Pentalgin with caffeine-containing drinks and other drugs that stimulate the central nervous system can lead to its overstimulation.

Contraindications

According to the instructions, Pentalgin has a wide range of contraindications, namely:

• Erosive and ulcerative lesions of the gastrointestinal tract in the acute phase;
• A combination of bronchial asthma, recurrent nasal polyposis and paranasal sinuses due to intolerance to acetylsalicylic acid or other non-steroidal drugs;
• Severe renal failure;
• Condition after coronary artery bypass surgery;
• Paroxysmal tachycardia;
• Severe arterial hypertension;
• Gastrointestinal bleeding;
• Severe liver failure;
• Inhibition of bone marrow hematopoiesis;
• Severe organic diseases of the cardiovascular system, including acute myocardial infarction;
• Frequent ventricular extrasystole;
• Age up to 18 years;
• Hyperkalemia;
• Hypersensitivity to the components of Pentalgin.

• • Cerebrovascular diseases;
  • Peripheral arterial diseases;
  • Kidney and liver failure of mild or moderate severity;
  • Alcoholic liver damage;
  • Epilepsy;
  • Glucose-6-phosphate dehydrogenase deficiency;
  • Diabetes mellitus;
  • History of ulcerative lesions of the gastrointestinal tract;
  • Viral hepatitis;
  • Benign hyperbilirubinemia, including Gilbert, Dubin-Johnson and Rotor syndromes;
  • Tendency to seizures.

Side effects

When treated with Pentalgin, undesirable effects may develop, for example, allergic reactions, disturbances in the nervous, cardiovascular, digestive, genitourinary and hematopoietic systems, as well as sensory organs.
This may be accompanied by symptoms such as:

• • • itching, skin rash, urticaria;
    • angioedema, thrombocytopenia;
    • agranulocytosis, leukopenia, anemia;
    • methemoglobinemia, agitation, anxiety;
    • tremor, headache, sleep problems;
    • dizziness, irregular heartbeat, arrhythmia;
    • increased blood pressure, pain, erosive and ulcerative disorders of the gastrointestinal tract;
    • nausea, vomiting, constipation;
    • abnormalities in kidney function;
    • hearing loss.

Analogues and price

The main analogues are represented by drugs: Ibuprofen, Paracetamol, Pentalgin FS, Pentalgin Plus, Cardiomagnyl, Amizon and Analgin.

The price of Pentalgin tablets varies between 70-180 rubles. You can buy the drug at any pharmacy without a prescription.

Reviews about Pentalgin

As you know, various painkillers are very popular in society. A special need for them arises among people who are afraid or simply do not like to visit a doctor. Therefore, they make do with the means at hand, and to eliminate pain, they take Analgin, No-shpu, Pentalgin and Pentalgin-N. According to reviews, these drugs have completely different effects on different people.

In most cases, reviews of Pentalgin are associated with its use by women during menstruation if they are bothered by severe pain. Also, these green tablets help many people get rid of toothache and headaches for a while. On medical forums there are lengthy discussions on the topic: what does Pentalgin help best with? Patients often compare the effect of this drug and its other types, for example, Pentalgin FS, which helps many people eliminate muscle pain.

At the same time, experts never tire of clarifying what Pentalgin tablets are, what they help with, when and for how long they can be taken. The fact is that any pain already indicates that there is a malfunction in the body, which means it needs professional help. However, most people in such cases do not rush to see a doctor, but begin to look for remedies to relieve pain. You should be aware that this approach often complicates the course of the disease, the treatment of which over time will require more intervention and time.

Please also read the instructions for the medications:

What does Mig 400 help with? Instructions for use

Pentalgin is a combined analgesic based on paracetamol. The medicine has analgesic, antispasmodic, anti-inflammatory and antipyretic properties.

Release form and composition

The dosage form of Pentalgin is film-coated tablets.

The active ingredients of the drug include paracetamol (325 mg), naproxen (100 mg), caffeine (50 mg), drotaverine hydrochloride (40 mg), pheniramine maleate (10 mg).

Excipients: potato starch, microcrystalline cellulose, croscarmellose sodium, hyprolose, citric acid monohydrate, butylated hydroxytoluene, magnesium stearate, talc, quinoline yellow dye, indigo carmine.

To make the film shell, hypromellose, polysorbate 80, povidone, titanium dioxide, talc, quinoline yellow dye, and indigo carmine are used.

Indications for use

The use of Pentalgin is indicated for pain relief:

• Dental, headache (including pain associated with vasospasm in the brain), muscle or joint pain, as well as pain arising from algodismenorrhea, neuralgia, etc.;
• Caused by spasm of smooth muscles (according to the instructions, the drug is effective, including for renal colic, cholelithiasis, chronic cholecystitis, sphincter of Oddi dysfunction and a number of other diseases);
• Occurring against the background of injuries and surgical operations (including when pain is accompanied by the development of an inflammatory process).

In addition, Pentalgin can be used for colds that are accompanied by febrile syndrome (used as a symptomatic antipyretic and analgesic).

Contraindications

The instructions for Pentalgin indicate that the drug is contraindicated in:

• Erosive and ulcerative lesions of the digestive tract (in the acute stage);
• Gastric and intestinal bleeding;
• Full or partial combination of polypous rhinosinusitis, bronchial asthma and individual intolerance to acetylsalicylic acid or any other drug from the NSAID group (including a history);
• Severe forms of functional kidney and/or liver failure;
• Suppressed hematopoiesis;
• Conditions that result from coronary artery bypass surgery;
• Serious organic pathologies of the heart and blood vessels;
• Severe form of arterial hypertension;
• Paroxysmal tachycardia;
• Ventricular arrhythmia, accompanied by frequent extrasystoles;
• Hyperkalemia;
• Hypersensitivity to Pentalgin components;
• Pregnancy and lactation.

The use of Pentalgin in pediatrics is also prohibited: the drug is intended for the treatment of patients over 18 years of age.

Directions for use and dosage

Tablets are taken one at a time. 1-3 times a day. The highest daily dose is 4 tablets.

The instructions for Pentalgin indicate that when using the drug as an antipyretic, treatment should be continued for no more than 3 days. If the patient takes tablets for pain relief, the maximum duration of use is 5 days. The advisability of further use of Pentalgin should be determined only by the attending physician.

Side effects

In some patients, taking Pentalgin may be accompanied by the development of side effects. The annotation states that the drug can cause:

• Allergic reactions, manifested in the form of skin itching and rashes, urticaria, angioedema;
• Thrombocytopenia, methemoglobinemia, agranulocytosis, leukopenia, anemia;
• Increased anxiety, agitation, decreased concentration, increased reflexes, sleep disorders, headaches, dizziness;
• Arrhythmias, rapid heartbeat, increased blood pressure;
• Feeling of discomfort and pain in the epigastric region, erosive and ulcerative lesions of the digestive tract, nausea, constipation, vomiting;
• Liver and/or kidney dysfunction;
• Hearing impairment, the appearance of tinnitus, and in patients with closed-angle glaucoma - ocular hypertension;
• Tachypnea;
• Dermatitis.

If the severity of the described side effects worsens, as well as if any other reactions occur that are not described in the instructions, you must stop taking the drug and report them to your doctor.

special instructions

You should strictly adhere to the dosage regimen and duration of use of Pentalgin described in the instructions. If the doctor prescribes long-term treatment - more than 5 days, it is necessary to monitor the functional state of the liver and peripheral blood parameters.

• Other drugs that contain paracetamol and/or non-steroidal anti-inflammatory substances;
• Medicines that are used to relieve cold and flu symptoms.

The risk of developing hepatotoxicity increases with simultaneous use of Pentalgin with rifampicin, diflusinal, tricyclic antidepressants and barbiturates - these combinations should be avoided.

When conducting laboratory tests, it must be borne in mind that paracetamol can distort the plasma concentrations of uric acid and glucose.

If it is necessary to determine 17-ketosteroids, Pentalgin is discontinued 48 hours before the study. Naproxen, which is part of the tablets, increases bleeding time.

During treatment with Pentalgin you should:

• Refrain from drinking alcoholic beverages;
• Use caution when driving a vehicle and performing potentially hazardous work.

Analogues

According to the mechanism of action, analogues of Pentalgin are: Adjicold Hotmix, Calpol, Antigrippin, Caffetin, AntiFlu, Apap, Grippostad, GrippoFlu, Daleron, Ifimol, Children's Panadol, Dolaren, Coldrex, Coldfree, Maxicold, Migrenol, Novalgin, Paracetamol, Rinicold, Solpadeine, etc. .

Terms and conditions of storage

Pentalgin tablets should be stored in a dry, dark place, out of reach of children, at room temperature. Shelf life – 24 months.

Analgesic medications are used to relieve pain of various origins. Their group includes Pentalgin; the drug is very effective in its analgesic properties, while taking it helps reduce inflammation and normalize temperature.

Composition and mechanism of action of Pentalgin

The drug is produced by Pharmstandard. Several medications are produced under the Pentalgin brand, differing in composition. Therefore, Pentalgin is sold in pharmacies with the prefix H, CN and plus. The main similarity of all these drugs is the 5 components of active substances and almost the same analgesic effect.

The active ingredients in Pentalgin may contain:

The multicomponent composition of Pentalgin provides maximum and quickly onset analgesic effect. The medicine can be taken for pain accompanied by fever, spasms and inflammation.

The different composition of Pentalgin allows you to choose the most effective subtype of the drug in each specific case.

Regular Pentalgin is available in the form of tablets, most often they are white, light green or green. There are inclusions on the fracture. The medicine is packaged in blisters of 4, 12 or 24 tablets.

Pentalgin is primarily a medicine for pain, so its use is advisable to eliminate:

• pain syndromes caused by osteochondrosis, radiculitis, neuralgia, joint pathologies, menstruation, dental problems;
• pain caused by spasm of smooth muscles during cholecystitis, urolithiasis and cholelithiasis;
• pain after injuries and operations;
• headaches.

Adults can take Pentalgin during the treatment of colds that occur with a rise in temperature.

Contraindications to Pentalgin

Before using Pentalgin, you need to study the instructions, since the list of contraindications to the use of the medicine is quite extensive. These include:

Failure to comply with contraindications increases the risk of adverse reactions, some of which can cause serious complications.

Possible adverse reactions

When taking Pentalgin, the occurrence of undesirable effects cannot be ruled out, most often these are:

Adverse reactions are mostly short-term in nature, that is, they disappear after discontinuation of the medication. But if the harm from the drug is greater than the benefit from it, then Pentalgin should be discontinued.

Regular Pentalgin is approved for use only from 18 years of age, but other subtypes of the drug can be used from 12 years of age.

Pregnant women should not take Pentalgin, as the active ingredients cross the placental barrier. The ban on the use of the medicine also applies to the lactation period.

Features of use

How many Pentalgin tablets are required per day depends on the intensity of the pain. However, the manufacturer does not recommend taking more than 4 tablets per day, and the interval between doses should be at least 6 hours.

It is better to take the tablet after a meal; with food, the components of the medicine dissolve faster, and the risk of negative effects on the mucous membranes of the digestive organs is reduced.

The duration of taking the medicine depends on the indications. As an anesthetic drug, Pentalgin is taken for no more than 5-7 days in a row; if the medication is used as an antipyretic, then the duration of its use is limited to three days.

Analogues of the drug

A package with a minimum number of tablets (4 pieces) costs an average of 45 rubles. If you are intolerant to certain components of the medication or if long-term use is necessary, analogues are selected, that is, drugs with an analgesic or antispasmodic effect.

Analogues of the drug should be selected taking into account all indications and contraindications for their use. Pentalgin is one of the most powerful painkillers. But it must be borne in mind that the maximum therapeutic effect of the drug appears only with the correct choice of drug depending on its composition.

Release form, composition and packaging

◊ Film-coated tablets light green to green in color, biconvex, capsule-shaped with beveled edges, scored on one side and embossed “PENTALGIN” on the other; When cut, the tablet is light green in color with white splashes.

Excipients: microcrystalline cellulose, potato starch, croscarmellose sodium, hyprolose (hydroxypropyl cellulose (Klucel EF)), citric acid monohydrate, butylated hydroxytoluene (E321), magnesium stearate, talc, quinoline yellow dye (E104), indigo carmine (E132).

Film shell composition: hypromellose (hydroxypropyl methylcellulose), povidone (medium molecular weight polyvinylpyrrolidone), polysorbate 80 (Tween 80), titanium dioxide, talc, quinoline yellow dye (E104), indigo carmine (E132).

12 pcs. - contour cellular packaging (1) - cardboard packs.

Clinical and pharmacological group

pharmachologic effect

The combined drug has analgesic, anti-inflammatory, antispasmodic, antipyretic effects.

Paracetamol- analgesic-antipyretic, has an antipyretic and analgesic effect due to the blockade of COX in the central nervous system and the effect on the centers of pain and thermoregulation.

Naproxen- NSAIDs have anti-inflammatory, analgesic and antipyretic effects associated with non-selective suppression of COX activity, which regulates the synthesis of prostaglandins.

Caffeine- a psychostimulant, causes dilation of the blood vessels of skeletal muscles, heart, kidneys; increases mental and physical performance, helps eliminate fatigue and drowsiness; increases the permeability of histohematic barriers and increases the bioavailability of non-narcotic analgesics, thereby enhancing the therapeutic effect. It has a tonic effect on the blood vessels of the brain.

Drotaverine- has a myotropic antispasmodic effect due to inhibition of PDE 4, acts on the smooth muscles of the gastrointestinal tract, biliary tract, genitourinary system, and blood vessels.

Pheniramine- blocker of histamine H1 receptors. It has an antispasmodic and mild sedative effect, reduces exudation, and also enhances the analgesic effect of paracetamol and naproxen.

Pharmacokinetics

Data on the pharmacokinetics of the drug Pentalgin ® are not provided.

Indications for use of the drug

— pain syndrome of various origins, including pain in joints, muscles, radiculitis, algodismenorrhea, neuralgia, toothache, headache (including those caused by cerebral vasospasm);

— pain syndrome associated with spasm of smooth muscles, incl. for chronic cholecystitis, cholelithiasis, postcholecystectomy syndrome, renal colic;

— post-traumatic and postoperative pain syndrome, incl. accompanied by inflammation;

- colds accompanied by febrile syndrome (as symptomatic therapy).

Dosage regimen

The drug is prescribed orally, 1 tablet. 1-3 times/day. The maximum daily dose is 4 tablets.

The duration of treatment is no more than 3 days as an antipyretic and no more than 5 days as an analgesic. Continuation of treatment with the drug is possible only after consultation with a doctor.

Do not exceed the indicated doses of the drug.

Side effect

Allergic reactions: skin rash, itching, urticaria, angioedema.

From the hematopoietic system: thrombocytopenia, leukopenia, agranulocytosis, anemia, methemoglobinemia.

From the side of the central nervous system: agitation, anxiety, increased reflexes, tremors, headache, sleep disturbances, dizziness, decreased concentration.

From the cardiovascular system: palpitations, arrhythmias, increased blood pressure.

From the digestive system: erosive and ulcerative lesions of the gastrointestinal tract, nausea, vomiting, epigastric discomfort, abdominal pain, constipation, impaired liver function.

From the urinary system: renal dysfunction.

From the senses: hearing loss, tinnitus, increased intraocular pressure in patients with angle-closure glaucoma.

Others: dermatitis, tachypnea (increased breathing).

If any of the side effects indicated in the instructions get worse, or the patient notices any other side effects not listed in the instructions, he should inform the doctor.

Contraindications to the use of the drug

- erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase);

- gastrointestinal bleeding;

- complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance to acetylsalicylic acid or other NSAIDs (including a history);

- severe liver failure;

- severe renal failure;

- inhibition of bone marrow hematopoiesis;

— condition after coronary artery bypass grafting;

- severe organic diseases of the cardiovascular system (including acute myocardial infarction);

- paroxysmal tachycardia;

- frequent ventricular extrasystole;

- severe arterial hypertension;

- hyperkalemia;

- pregnancy;

- lactation period (breastfeeding);

- children and adolescents up to 18 years of age;

- hypersensitivity to the components of the drug.

WITH caution the drug should be used in patients with cerebrovascular diseases, diabetes mellitus, peripheral arterial diseases, a history of ulcerative lesions of the gastrointestinal tract, mild or moderate renal and liver failure, viral hepatitis, alcoholic liver damage, benign hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor), epilepsy, with a tendency to seizures, deficiency of glucose-6-phosphate dehydrogenase, in elderly patients. If any of the listed diseases and conditions are present, the patient should consult a doctor before using the drug.

Use of the drug during pregnancy and lactation

The use of the drug is contraindicated during pregnancy and lactation (breastfeeding).

Use for liver dysfunction

Use is contraindicated in severe liver failure.

Use for renal impairment

Use is contraindicated in severe renal failure.

special instructions

The simultaneous use of Pentalgin ® with other drugs containing paracetamol and/or NSAIDs, as well as with drugs to relieve symptoms of colds, flu and nasal congestion should be avoided.

When using the drug Pentalgin ® for more than 5-7 days, peripheral blood counts and the functional state of the liver should be monitored.

Paracetamol distorts the results of laboratory tests of glucose and uric acid in blood plasma.

If it is necessary to determine 17-ketosteroids, Pentalgin ® should be discontinued 48 hours before the study. Please note that naproxen increases bleeding time.

The effect of caffeine on the central nervous system depends on the type of nervous system and can manifest itself as both excitation and inhibition of higher nervous activity.

During the treatment period, the patient should avoid drinking alcohol.

Impact on the ability to drive vehicles and operate machinery

In some cases, a decrease in concentration and speed of psychomotor reactions is possible, therefore, during the treatment period, the patient should be careful when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Overdose

Symptoms: pale skin, anorexia (lack of appetite), abdominal pain, nausea, vomiting, gastrointestinal bleeding, agitation, restlessness, confusion, tachycardia, arrhythmia, hyperthermia (increased body temperature), frequent urination, headache, tremor or muscle twitching; epileptic seizures, increased activity of liver transaminases, hepatonecrosis, increased prothrombin time. Symptoms of liver dysfunction may appear 12-48 hours after an overdose. In case of severe overdose, liver failure develops with progressive encephalopathy, coma, and death; acute renal failure with tubular necrosis; arrhythmia, pancreatitis. If you suspect an overdose, you should immediately seek medical help.

Treatment: gastric lavage followed by taking activated charcoal. The specific antidote for paracetamol poisoning is acetylcysteine. The administration of acetylcysteine ​​is important within 8 hours after taking paracetamol. In case of gastrointestinal bleeding, it is necessary to administer antacids and gastric lavage with an ice-cold 0.9% sodium chloride solution; maintaining pulmonary ventilation and oxygenation; for epileptic seizures - intravenous administration of diazepam; maintaining fluid and salt balance.

Drug interactions

When taking the drug Pentalgin ® simultaneously with barbiturates, tricyclic antidepressants, rifampicin, ethanol, the risk of hepatotoxicity increases (these combinations should be avoided).

Paracetamol enhances the effect of indirect anticoagulants and reduces the effectiveness of uricosuric drugs.

Long-term use of barbiturates reduces the effectiveness of paracetamol.

When used simultaneously with paracetamol and ethanol, the risk of acute pancreatitis increases.

Inhibitors of microsomal oxidation (including cimetidine) reduce the risk of hepatotoxic action of paracetamol.

Diflunisal increases the plasma concentration of paracetamol by 50%, which increases the risk of hepatotoxicity.

Naproxen can cause a decrease in the diuretic effect of furosemide, an increase in the effect of indirect anticoagulants, increases the toxicity of sulfonamides and methotrexate, reduces the excretion of lithium and increases its concentration in the blood plasma.

With the combined use of caffeine and barbiturates, primidone, anticonvulsants (hydantoin derivatives, especially phenytoin), it is possible to increase metabolism and increase the clearance of caffeine; while taking caffeine and cimetidine, oral contraceptives, disulfiram, ciprofloxacin, norfloxacin - a decrease in the metabolism of caffeine in the liver (slowing its excretion and increasing its concentration in the blood).

Concomitant use of caffeinated beverages and other CNS stimulants may result in excessive CNS stimulation.

When used concomitantly, drotaverine may weaken the antiparkinsonian effect of levodopa.

With simultaneous use of pheniramine with tranquilizers, hypnotics, MAO inhibitors, ethanol, the depressant effect on the central nervous system may be enhanced.

Conditions for dispensing from pharmacies

The drug is approved for use as a means of OTC.

Storage conditions and periods

The drug should be stored out of the reach of children, in a dry place, protected from light, at a temperature not exceeding 25°C. Shelf life - 2 years.