Pyobacteriophage: instructions for use. Pyobacteriophages for children: instructions for use Pyobacteriophage combined instructions for use

Content

Diseases caused by bacterial infections can affect anyone, almost anywhere. Treatment of such problems is always complex. In recent years, bacteriophages have become the main component of therapy. These are specific viruses that destroy pathogenic bacteria. The use of drugs in this group has made it possible to advance in the treatment of many infectious diseases. The main thing is to accurately diagnose the type of pathogenic bacteria in order to select a bacteriophage suitable for therapy.

Instructions for use of Pyobacteriophage

Translated from Greek, bacteriophages are bacteria eaters. This biological term refers to special viruses that destroy “bad” bacterial cells. Phages are the most ancient and widespread form of viruses. They are in close proximity to bacteria. Their habitat is water, soil, air, living organisms, including humans.

Bacteriophages are already a worthy competitor to antibiotic therapy. Their advantages are:

• targeted effect – beneficial bacterial flora remains unharmed;
• no contraindications or addiction;
• effective combination in complex therapy;
• no inhibitory effect on the immune system;
• a pronounced effect in the treatment of indolent painful conditions caused by bacterial resistance to antibiotics.

Composition and release form

The drug consists of main and additional components. A detailed display of this data is presented in the table:

pharmachologic effect

The destructive activity of the virus begins with the fact that it injects its genetic information into the body of the bacterium. Then the active reproduction of the bacteriophage begins. When a bacterial cell is destroyed, up to 200 phages are released. They immediately begin to destroy pathogenic bacteria around. Further proliferation of microorganisms continues until the complete absence of pathogenic cells.

Indications for use

• surgical – abscess, paraproctitis, osteomyelitis, purulent wounds, boils;
• enteral - dysbacteriosis, cholecystitis, gastritis, colitis;
• respiratory tract diseases - bronchitis, tracheitis, laryngitis, pneumonia;
• urogenital – colpitis, endometritis, cystitis, pyelonephritis, vaginal dysbiosis;
• purulent bacterial lesions of the eyes – conjunctivitis;
• blood poisoning - sepsis;
• diseases of the ENT organs - otitis media, tonsillitis, sinusitis.

The drug is used to treat any diseases caused by bacteria of staphylococcus, streptococcus, enterococci and other representatives of this group. For the purpose of prevention, bacteriophage is used to treat fresh infected surgical wounds. For epidemic indications - for the prevention of nosocomial infections.

Directions for use and dosage

The method of using Pyobacteriophage depends on the nature and location of the inflammation. Depending on these factors, the method of using the drug is divided into several types:

• orally – taking the medicine by mouth;
• rectally - administration of the phage using an enema;
• locally - irrigation, lotions, rinsing, instillation, washing, administration of turundas soaked in solution.

The dosage varies depending on the disease. It is divided as follows:

• Cavity wounds – up to 200 ml inside the cavity. For osteomyelitis – 10-20 ml.
• Into the cavity of the bladder, renal pelvis through capillary drainage 20-50 ml and 5-7 ml.
• Gynecology – intrauterine, intravaginal tampon 5-10 ml once a day.
• ENT organs – 2-10 ml 1-3 times a day. Turunda – for 1 hour.
• Ophthalmology – conjunctivitis, 3 drops 2-3 times, purulent corneal ulcer – 4-5 drops, purulent iridocyclitis – 6-8 drops every 3 hours.
• Stomatitis, periodontitis - rinsing 10-20 ml 3 times a day.
• Intestinal infections, dysbacteriosis - 3 times a day an hour before meals. Enema replaces 1 appointment.

The dosage for children depends not only on the cause of the disease and its duration. Age is the most important criterion for establishing specific volumes of the drug. The result of treatment depends on this. Age data regarding children is given in the table:

Pyobacteriophage polyvalent purified

The drug is a type of Pyobacteriophage. After the destruction of the bacterial cell culture, the resulting phages are isolated, filtered, purified and packaged under sterile conditions. The bacteria to be treated are Pseudomonas aeruginosa and Escherichia coli, streptococcus, staphylococcus, Klebsiella, and Proteus. The liquid is an antibacterial and immunostimulating agent. It is used for the treatment and prevention of purulent-inflammatory infections of the throat, eyes, and burns.

Pyobacteriophage complex

The same bacteriophage, only with an expanded name, which each manufacturer tries to make more memorable. The drug is presented in the form of a purified liquid and contains a mixture of active phage viruses. The substance is used in complex therapy to treat or prevent various types of infections - peritonitis, pleurisy, and genitourinary system organs. The bacteriophage is indicated for use from the first days of life.

Sextaphage pyobacteriophage polyvalent

Sextaphage or Pyobacteriophage is a drug that is a mixture of sterile filters of viral phages. Available in ampoules or bottles with a yellowish, sometimes greenish liquid. The scope, properties and effectiveness of the drug are similar to the original one. The dosage and method of application are the same as the purified bacteriophage. The drug is used for purulent inflammation with increased body temperature, disturbances in stool and intestinal microflora.

Staphylococcal

Enemas

Administration of the drug directly into the intestines using an enema is indicated for infections caused by bacteria - pathogens against which the drug's bacteriophages are specific. In this case, a high enema is used - it requires a longer tip and a tube that raises the container with the drug. These enemas are used for:

• administering medication to newborns and infants;
• preoperative preparation in proctology departments;
• gynecological diseases, before operations;
• generalized exposure during the chronic course of the disease or a large area affected by infection.

Nose drops

Pyobacteriophage is often used to treat purulent infections of the nasal cavity and sinuses. In this case, instillations, rinsing, and irrigation of the inflammation site are used. In the treatment of sinusitis, applications that are applied to cotton swabs are common. They must be inserted into the nasal passage for at least 1 hour. Instillation is prescribed at the rate of 2-10 ml for both nasal sinuses. The procedure is repeated 1 to 3 times a day. This method is used for inflammation of the nasal mucosa during complicated ARVI.

special instructions

Before each use, the vial with the bacteriophage must be shaken and inspected. If there is cloudiness, the drug cannot be used. To avoid bacteria from the external environment entering the container, you should follow some rules:

1. Wash your hands with special care.
2. Treat the cap with an alcohol solution.
3. Without opening the cork, remove the protective shell from it.
4. If the cork does open, do not allow it to come into contact with the table surfaces. You can put it on a napkin soaked in alcohol.
5. After use, you must keep the bottle closed.

When using small doses - from 2 to 8 drops, the drug must be taken from the bottle using a sterile syringe with a volume of 0.5-1 ml. There is no information about the possible effect of taking bacteriophage on the ability to drive vehicles or operate precision machinery. In retail pharmacy chains, the drug is dispensed without a doctor's prescription.

Pyobacteriophage during pregnancy

During pregnancy, the bacteriophage is indicated for use in purulent and inflammatory processes. The same applies to the period of breastfeeding. Due to their specific effects, phages have a destructive effect only on pathogenic cells, without affecting healthy ones. But without an accurate clarification of the nature of the disease, it is impossible to self-medicate. At the same time, consultation with a gynecologist or pediatrician regarding the use of bacteriophage will not be superfluous.

In childhood

For newborns and children up to 6 months, the drug is used in the treatment of sepsis and enterocolitis in the form of high enemas. Oral administration is possible if there is no regurgitation. In this case, the substance is diluted with breast milk. For effective therapy, a combination of rectal and oral routes of drug administration is indicated. The course of treatment is 5-15 days. Prevention lasts 5-7 days. Treatment of pyoderma, omphalitis, and infected wounds involves the use of applications 2 times a day. To do this, a sterile napkin is moistened with the substance and applied to the umbilical wound.

Drug interactions

The use of bacteriophage can be carried out in combination with other antibacterial drugs. Research has shown that phages can enhance the effects of antibiotics when the pathogen is correctly identified. But if before using the drug, chemical antiseptics were used to treat wounds, they should be thoroughly washed with a sterile solution of sodium chloride 0.9%.

Alcohol compatibility

The effect of alcohol on the effect of the drug has not been established. Research of this kind simply has not been conducted. But to be confident in the results of therapy, you should refrain from drinking strong alcoholic beverages. Moreover, they are not compatible with most antibacterial drugs, which are often used in complex treatment with bacteriophages.

Side effects

There were no cases of side effects while taking the drug. In very rare cases, individual intolerance to any components is possible. This is expressed by nausea and dizziness. The cause of such conditions is not so much the drug itself as its improper use or violation of the shelf life or instructions for use.

Overdose

Exceeding the dosage specified in the instructions does not pose any danger to human health. There is no data on changes in status in case of overdose. It is recommended to observe accurate calculations of the required doses due to the low cost of the drug. This will eliminate the need to purchase additional bottles of the substance so that it is enough for the entire course of treatment prescribed by a specialist.

Contraindications

There are no direct contraindications to the use of bacteriophage. The use of the drug during pregnancy and lactation, children under 6 months can be considered relative. In these cases, consultation with a specialist is necessary to determine the cause of infection, select complex therapy, accurately calculate the dosage and course of treatment.

Terms of sale and storage

The shelf life of the bacteriophage is 24 months. In this case, storage conditions must be observed - a dry, dark place, away from children. The temperature ranges from +2 to +10 degrees. In this case, transportation can be carried out up to +25 degrees for 1 month. An expired bottle must not be used for medical purposes. It won't do any harm, but it won't have a therapeutic effect either.

Analogs

Some drugs contain Pyobacteriophage. Analogs by international nonproprietary name are:

• Sextaphage is polyvalent - specifically dissolves pathogenic bacteria.
• Piopolyphage - lyses pathogenic bacterial cells, including enterococci.
• Polyvalent bacteriophage purified liquid - filtrate of viral bacteriophages.
• complex Pyobacteriophage combined liquid - destroys microbes without disturbing the natural balance of the body.
Online pharmacy "Dialogue"

Pharmacy chain "36.6"

Samon-Pharma

eApteka.ru

"Neopharm"

"ZdravZona"

Unfortunately, inflammatory diseases of bacterial origin can hardly be considered rare. Every person faces similar problems from time to time, regardless of age, gender or other indicators. So what treatments does modern medicine offer for treating such ailments?

Today, drugs based on bacteriophages are becoming increasingly popular. And quite often doctors prescribe the drug “Piobacteriophage” to their patients. The instructions for using it are quite simple, but it really does have an effect. But what is special about this drug? What does it contain? Are there any contraindications to therapy? This information will be of interest to many readers.

Description of the composition and release form of the drug

The drug “Pyobacteriophage complex liquid” is available in the form of a transparent yellowish solution. The liquid is placed in glass bottles with a capacity of 20 or 100 ml.

This drug is a mixture of bacteriophages that are obtained by lysis of bacterial cells. In particular, the solution contains bacteriophages that are active against enterococci, staphylococci, streptococci, Klebsiella, Escherichia coli, Pseudomonas and Proteus. The resulting lysate is carefully filtered to remove pathogenic cell residues during the production process. Quinosol is used as a supporting buffer. By the way, the solution should be stored at a temperature of 2-8 degrees Celsius.

What properties does the drug have?

What effect can the drug “Piobacteriophage” provide? The instructions say that the medicine copes well with various types of infections. But why?

In fact, such medicines have unique properties. Bacteriophages are types of viruses that infect bacterial cells. Penetrating through the cell wall, the virus begins to actively multiply, using cellular resources for this. This, in turn, leads to the death of bacteria, lysis of their walls and the release of new viral particles.

It is also worth noting that the action of bacteriophages is highly specific. Viral particles infect only certain bacterial cells, without affecting either the structures of the body or the beneficial bacteria that are necessary to maintain the normal functioning of organ systems.

Indications for use

In what cases are patients prescribed the drug “Piobacteriophage”? The use of this tool is quite widespread. It is used to treat inflammatory diseases caused by the activity of phage-sensitive bacteria.

For example, taking the medicine is indicated for intestinal infections. In surgical practice, the drug is used to treat suppurations, burns, carbuncles, phlegmons, and boils. Also indications for use are infectious tonsillitis, otitis, pharyngitis, sinusitis, pleurisy, pneumonia, pyelonephritis, cystitis, colpitis, salpingo-oophoritis, etc.

The drug "Piobacteriophage": instructions for use

Only a doctor can prescribe the use of this drug. The specialist will also determine the maximum effective dose and duration of therapy. So how to use the Piobacteriophage product correctly? The instructions in this case depend on the form of the disease, the patient’s condition and some other factors.

• For example, for skin lesions, the solution is used in the form of wet dressings, applications, irrigations, lotions, etc.
• When treating an abscess, a solution with bacteriophages is injected directly into the suppuration cavity, having previously thoroughly cleaned it of existing purulent masses.
• For diseases of the excretory system, the solution can be injected directly into the renal pelvis or into the cavity of the bladder.
• The drug can also be used for instillation, washing, gargling (for example, throat), irrigation.
• For intestinal diseases, enemas based on this solution will be effective.
• However, the drug is most often prescribed orally. In addition, for some diseases it is advisable to combine several methods of administration at once to achieve maximum results.

The single dose is determined by the doctor. For adult patients and children over eight years of age, it is usually 50 ml. You need to take the drug three times a day (the number of doses may be reduced if therapy includes other procedures, such as enemas). The course of treatment in most cases lasts from 5 to 15 days. If we are talking about the prevention of a particular disease, then a seven-day intake will be enough.

Features of treatment of children under 6 months of age

Of course, this drug is widely used in pediatrics for the treatment of newborns and children in the first months of life. Treatment with “Pyobacteriophage” in this case has some features that are worth paying attention to.

When treating enterocolitis or sepsis in newborns (including premature babies), the method of so-called high enemas is used. Special catheters are used to irrigate the intestines. A single dose of enema medication is 10 ml, the procedure is repeated 2-3 times a day. If there is no vomiting, then the child can be given the solution orally, mixed with formula or breast milk - a single dose is 5 ml. Quite often, doctors recommend combining rectal and oral routes of drug administration. The course of therapy usually lasts from 5 to 15 days.

Are there any contraindications and side effects?

Of course, many people are interested in the question of whether all categories of patients are allowed to take the drug “Piobacteriophage”? The instructions state that this product has no contraindications. Moreover, no cases of severe adverse reactions have been reported. Sometimes patients experience a slight allergic reaction, but this is extremely rare.

The drug “Pyobacteriophage complex liquid” is often used to treat even newborns. Moreover, the drug is indispensable in the treatment of certain infections during pregnancy, because during this period of a woman’s life, traditional antibacterial therapy with antibiotics can only do harm.

But, despite all the safety, you should not use the medicine without permission - be sure to consult your doctor before starting therapy.

How much does the medicine cost?

For many patients, the issue of cost of a particular medicine is important. So how much will the drug “Piobacteriophage” cost? The price, of course, may fluctuate depending on the volume you purchase, the manufacturer, as well as the financial policy of the pharmacy.

On average, a package costs 900 rubles. But you need to keep in mind that to complete the full course of treatment you will most likely need several of these packages.

What to do if, for one reason or another, you cannot use the “Complex Liquid Pyobacteriophage”? The bacteriophage is also contained in some other drugs; if necessary, you can choose a substitute with almost the same properties. For example, such products as “Piobacteriophage polyvalent purified”, “Piopolyphage”, “Sextaphage” and some others are considered good analogues.

The drug "Piobacteriophage": reviews from doctors and patients

Today, drugs based on bacteriophages are becoming more and more popular. After all, standard therapy with antibiotics is not suitable for everyone and is often associated with side effects. And in such cases, doctors prescribe the drug “Piobacteriophage”. Reviews from doctors are positive, as the drug copes with its main task excellently.

Patients also respond well to this product. It helps to cope with staphylococcus and other pathogenic microorganisms, does not harm health and has practically no contraindications. As for the negative aspects, it is worth mentioning the price, which may be too high for some patients. The disadvantages include a not very pleasant taste, as well as some difficulties that arise with storing the drug. But in any case, health is worth all the inconvenience.

Compound

pharmachologic effect

Indications for use

Mode of application

Depending on the location of the infection, Pyobacteriophage is recommended for:
1. Local application in the form of lotions, irrigations, applications and tampons, moistened solutions. In this case, use the required amount of solution based on the size of the affected area. For abscesses, the solution should be injected into the cavity after removing the pus by puncture (the volume of the solution should be slightly less than the volume of the extracted pus).
2. Injection of the solution into the pleural, articular and other limited cavities. After administering the required amount of bacteriophage, capillary drainage is left, through which repeated doses of the drug are subsequently administered.
3. Injection of the solution into the drained cavity of the bladder and renal pelvis through a cystostomy or nephrostomy.
4. Introducing the solution into the uterine or vaginal cavity, including in the form of tampons soaked in the solution.
5. Instillation, washing and rinsing, as well as the introduction of turundas moistened with a solution, in otolaryngological practice.
6. Applications to the conjunctival sac in ophthalmological practice.
7. Insertion of moistened turundas into periodontal pockets in dental practice.
8. Introductions into the rectum in the form of enemas in gastroenterological practice.

The dose of the drug Piobacteriophage and the duration of the course of therapy are determined by the doctor.
A single dose recommended for children under 6 months is 5 ml when administered orally or 10 ml when administered rectally.
A single dose recommended for children 6-12 months is 10 ml when administered orally and 20 ml when administered rectally.
A single dose recommended for children 1-3 years old is 15 ml when administered orally and 30 ml when administered rectally.
A single dose recommended for children 3-8 years old is 20 ml when administered orally and 40 ml when administered rectally.
A single dose recommended for children over 8 years of age and adults is 30 ml when administered orally and 50 ml when administered rectally.

In the treatment of purulent-inflammatory diseases and intestinal diseases, as a rule, the appropriate single dose is prescribed three times a day.
If, when using a bacteriophage locally, the wound was pre-treated with an antiseptic, it is necessary to wash the wound with a 0.9% sodium chloride solution before using the Pyobacteriophage solution.
For children under 6 months of age with enterocolitis and sepsis, Piobacteriophage solution is administered in the form of high enemas twice or thrice a day. If the child does not develop regurgitation and vomiting, the drug can be given orally.
The average duration of therapy is from 5 to 15 days.
As a prophylaxis, the drug is prescribed in a single dose twice a day for 5-7 days.

Side effects

Contraindications

Pregnancy

Drug interactions

Overdose

Release form

Storage conditions

Nosological classification (ICD-10)

Streptococcal septicemia (A40)

Other septicemia (A41)

Other acute conjunctivitis (H10.2)

Corneal ulcer (H16.0)

Keratoconjunctivitis (H16.2)

Acute and subacute iridocyclitis (H20.0)

Hundreds of suppliers bring hepatitis C medications from India to Russia, but only M-PHARMA will help you buy sofosbuvir and daclatasvir, and professional consultants will answer any of your questions throughout the entire treatment.

"Pyobacteriophage"

Unfortunately, inflammatory diseases of bacterial origin can hardly be considered rare. Every person faces similar problems from time to time, regardless of age, gender or other indicators. So what treatments does modern medicine offer for treating such ailments?

Today, drugs based on bacteriophages are becoming increasingly popular. And quite often doctors prescribe the drug “Piobacteriophage” to their patients. The instructions for using it are quite simple, but it really does have an effect. But what is special about this drug? What does it contain? Are there any contraindications to therapy? This information will be of interest to many readers.

Description of the composition and release form of the drug

The drug “Pyobacteriophage complex liquid” is available in the form of a transparent yellowish solution. The liquid is placed in glass bottles with a capacity of 20 or 100 ml.

This drug is a mixture of bacteriophages that are obtained by lysis of bacterial cells. In particular, the solution contains bacteriophages that are active against enterococci, staphylococci, streptococci, Klebsiella, Escherichia coli, Pseudomonas and Proteus. The resulting lysate is carefully filtered to remove pathogenic cell residues during the production process. Quinosol is used as a supporting buffer. By the way, the solution should be stored at a temperature of 2-8 degrees Celsius.

What properties does the drug have?

What effect can the drug “Piobacteriophage” provide? The instructions say that the medicine copes well with various types of infections. But why?

In fact, such medicines have unique properties. Bacteriophages are types of viruses that infect bacterial cells. Penetrating through the cell wall, the virus begins to actively multiply, using cellular resources for this. This, in turn, leads to the death of bacteria, lysis of their walls and the release of new viral particles.

It is also worth noting that the action of bacteriophages is highly specific. Viral particles infect only certain bacterial cells, without affecting either the structures of the body or the beneficial bacteria that are necessary to maintain the normal functioning of organ systems.

Indications for use

In what cases are patients prescribed the drug “Piobacteriophage”? The use of this tool is quite widespread. It is used to treat inflammatory diseases caused by the activity of phage-sensitive bacteria.

For example, taking the medicine is indicated for intestinal infections. In surgical practice, the drug is used to treat suppurations, burns, carbuncles, phlegmons, and boils. Also indications for use are infectious tonsillitis, otitis, pharyngitis, sinusitis, pleurisy, pneumonia, pyelonephritis, cystitis, colpitis, salpingo-oophoritis, etc.

The drug "Piobacteriophage": instructions for use

Only a doctor can prescribe the use of this drug. The specialist will also determine the maximum effective dose and duration of therapy. So how to use the Piobacteriophage product correctly? The instructions in this case depend on the form of the disease, the patient’s condition and some other factors.

• For example, for skin lesions, the solution is used in the form of wet dressings, applications, irrigations, lotions, etc.
• When treating an abscess, a solution with bacteriophages is injected directly into the suppuration cavity, having previously thoroughly cleaned it of existing purulent masses.
• For diseases of the excretory system, the solution can be injected directly into the renal pelvis or into the cavity of the bladder.
• The drug can also be used for instillation, washing, gargling (for example, throat), irrigation.
• For intestinal diseases, enemas based on this solution will be effective.
• However, the drug is most often prescribed orally. In addition, for some diseases it is advisable to combine several methods of administration at once to achieve maximum results.

The single dose is determined by the doctor. For adult patients and children over eight years of age, it is usually 50 ml. You need to take the drug three times a day (the number of doses may be reduced if therapy includes other procedures, such as enemas). The course of treatment in most cases lasts from 5 to 15 days. If we are talking about the prevention of a particular disease, then a seven-day intake will be enough.

Features of treatment of children under 6 months of age

Of course, this drug is widely used in pediatrics for the treatment of newborns and children in the first months of life. Treatment with “Pyobacteriophage” in this case has some features that are worth paying attention to.

When treating enterocolitis or sepsis in newborns (including premature babies), the method of so-called high enemas is used. Special catheters are used to irrigate the intestines. A single dose of enema medication is 10 ml, the procedure is repeated 2-3 times a day. If there is no vomiting, then the child can be given the solution orally, mixed with formula or breast milk - a single dose is 5 ml. Quite often, doctors recommend combining rectal and oral routes of drug administration. The course of therapy usually lasts from 5 to 15 days.

Are there any contraindications and side effects?

Of course, many people are interested in the question of whether all categories of patients are allowed to take the drug “Piobacteriophage”? The instructions state that this product has no contraindications. Moreover, no cases of severe adverse reactions have been reported. Sometimes patients experience a slight allergic reaction, but this is extremely rare.

The drug “Pyobacteriophage complex liquid” is often used to treat even newborns. Moreover, the drug is indispensable in the treatment of certain infections during pregnancy, because during this period of a woman’s life, traditional antibacterial therapy with antibiotics can only do harm.

But, despite all the safety, you should not use the medicine without permission - be sure to consult your doctor before starting therapy.

How much does the medicine cost?

For many patients, the issue of cost of a particular medicine is important. So how much will the drug “Piobacteriophage” cost? The price, of course, may fluctuate depending on the volume you purchase, the manufacturer, as well as the financial policy of the pharmacy.

On average, a package costs 900 rubles. But you need to keep in mind that to complete the full course of treatment you will most likely need several of these packages.

What to do if, for one reason or another, you cannot use the “Complex Liquid Pyobacteriophage”? The bacteriophage is also contained in some other drugs - if necessary, you can choose a substitute with almost the same properties. For example, such products as “Piobacteriophage polyvalent purified”, “Piopolyphage”, “Sextaphage” and some others are considered good analogues.

The drug "Piobacteriophage": reviews from doctors and patients

Today, drugs based on bacteriophages are becoming more and more popular. After all, standard therapy with antibiotics is not suitable for everyone and is often associated with side effects. And in such cases, doctors prescribe the drug “Piobacteriophage”. Reviews from doctors are positive, as the drug copes with its main task excellently.

Patients also respond well to this product. It helps to cope with staphylococcus and other pathogenic microorganisms, does not harm health and has practically no contraindications. As for the negative aspects, it is worth mentioning the price, which may be too high for some patients. The disadvantages include a not very pleasant taste, as well as some difficulties that arise with storing the drug. But in any case, health is worth all the inconvenience.

www.syl.ru

PYOBACTERIOPHAGE POLYVALENT PURIFIED

Before use, the vial with the bacteriophage must be shaken and inspected. The preparation must be transparent and free of sediment.

Attention! If cloudy, do not use the drug!

Due to the content of a nutrient medium in the drug, in which bacteria from the environment can develop, causing cloudiness of the drug, the following rules must be observed when opening the bottle:

Wash your hands thoroughly;

Treat the cap with an alcohol-containing solution; remove the cap without opening the stopper;

Do not place the cork with the inner surface on a table or other objects;

Do not leave the bottle open;

Store an opened bottle only in the refrigerator.

When using small doses (2-8 drops), the drug must be taken with a sterile syringe in a volume of 0.5-1 ml.

The drug from an opened bottle, subject to storage conditions, the above rules and the absence of turbidity, can be used throughout the shelf life.

The drug is used for oral administration (orally), in the form of enemas, applications, irrigations, injection into wound cavities, vagina, uterus, nose, sinuses, as well as into drained cavities: abscesses, abdominal, pleural, bladder, renal pelvis.

The drug is taken orally on an empty stomach 0.5-1 hour before meals.

Treatment of purulent-inflammatory diseases with localized lesions should be carried out simultaneously both locally and by taking the drug orally.

If the cavity of a purulent lesion is treated with chemical antiseptics, before using the bacteriophage, it must be washed with a sterile 0.9% sodium chloride solution.

When treating tonsillitis, pharyngitis, laryngitis, the drug is used to rinse the mouth and throat 3 times a day, 10-20 ml, the course of treatment is 7-10 days.

When treating bronchitis and pneumonia, the drug is taken orally 3 times a day, 10-20 ml, and is also used in the form of aerosols and inhalations (without heating and the use of ultrasound), the course of treatment is 15-20 days.

In the treatment of otitis, the drug is used for washing and introducing 2-5 ml into the middle ear cavity 1-3 times a day. The course of treatment is 7-15 days.

When treating inflammation of the sinuses, the drug is used to rinse the nasal cavity, nasopharynx and sinuses in a dose of 5-10 ml and inject 2-3 ml into the sinuses. The procedure is repeated once daily for 7-10 days. In addition, the drug is administered into the nasal cavity in the form of turundas moistened with bacteriophage, in turn into each nasal passage and left for 0.5-1 hour. The procedure is repeated 3 times a day, the course of treatment is 7-15 days.

In the treatment of stomatitis and chronic periodontitis, the drug is used in the form of rinses in the mouth 3-4 times a day in a dose of 10-20 ml, as well as by introducing turundas impregnated with bacteriophage into the periodontal pockets for 5-10 minutes, the course of treatment is 7-10 days.

For conjunctivitis and keratoconjunctivitis, the drug is used 2-3 drops 4-5 times a day, the course of treatment is 5-7 days; for a purulent corneal ulcer - 4-5 drops per day for 7-10 days, for purulent iridocyclitis - 6-8 drops every 3 hours in combination with oral administration in therapeutic dosages for 7-10 days.

In case of an abscess, after opening and removing the purulent contents, the drug is administered in an amount less than the volume of removed pus once daily, the course of treatment is 7-10 days.

For peritonitis and pleurisy, the drug is administered into the drained cavities - abdominal and pleural through drainage tubes - 20-70 ml once daily, the course of treatment is 10-15 days.

For osteomyelitis, the drug is administered into the wound cavity through turundas and drainages in the amount of 10-30 ml once daily, the course of treatment is 15-20 days.

In the treatment of mastitis, suppuration of wounds and burns, the drug is used in the form of irrigation, applications, dressings, injection into drainage in a dose of 5-50 ml depending on the lesion at least 1 time per day, the course of treatment is 10-15 days.

In the treatment of purulent-inflammatory gynecological diseases (suppuration of wounds, endometritis, vulvitis, bartholinitis, colpitis, salpingoophoritis), the drug is used for irrigation, applications, administered into wound cavities, vagina, uterus, 5-20 ml once a day for 7-10 days.

For cystitis, pyelonephritis, urethritis, the drug is taken orally in a therapeutic dose 3 times a day 1 hour before meals for 10-20 days. If the cavity of the bladder or renal pelvis is drained, the drug is administered through a cystostomy or nephrostomy 1-3 times a day, 20-50 ml into the bladder and 5-7 ml into the renal pelvis, the course of treatment is 7-15 days.

For gastroenterocolitis, pancreatitis, cholecystitis, as well as intestinal dysbiosis, the bacteriophage is taken orally in age-specific dosages 3 times a day 1 hour before meals for 7-15 days (according to clinical indications). For indomitable vomiting, the drug is used in the form of high enemas 2-3 times a day, 20-40 ml. In case of intestinal dysbiosis, the drug can be used with normal flora preparations.

To prevent hospital-acquired surgical infections, the drug is used to treat postoperative and newly infected wounds in a dose of 5-50 ml, depending on the lesion, once daily for 5-7 days.

Use of the drug in children under 1 year of age (including premature infants)

For gastroenterocolitis, pneumonia and sepsis of newborns, the drug is used by mouth 2-3 times a day, 3-5 ml, 30 minutes before feeding. In cases of indomitable vomiting, the drug is used in the form of high enemas (through a gas outlet tube or catheter) once daily in a dose of 5-10 ml. A combination of rectal (in the form of high enemas) and oral administration of the drug is possible. The course of treatment is 7-15 days (according to clinical indications). In case of recurrent course of the disease, repeated courses of treatment are possible.

In the treatment of omphalitis, pyoderma, and infected wounds, the bacteriophage is used in the form of applications of 5-10 ml 2-3 times a day (a gauze pad is moistened with the bacteriophage and applied to the umbilical wound or affected area of ​​skin) for 7-15 days.

In order to prevent the occurrence of nosocomial infection in newborns, the bacteriophage is used according to epidemic indications orally 3-5 ml 3 times a day 30 minutes before feeding during the entire period of hospital stay.

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Polyvalent Pyobacteriophage

Compound

The drug contains the active ingredient pyobacteriophage (a mixture of filtrates of sterile phagolysates, streptococci, Proteus, Pseudomonas aeruginosa, staphylococci, enterococci, Klebsiella, Escherichia coli) 10 ml per bottle.

The drug also contains excipients - preservatives.

Release form

Solution in a bottle of 20 ml, ampoules of 10 and 5 ml. There are 4 bottles in a cardboard package, ampoules - 5 or 10 pieces.

pharmachologic effect

Antibacterial, immunostimulating agent.

Pharmacodynamics and pharmacokinetics

The drug specifically lyses bacteria Proteus, streptococci, staphylococci, Klebsiella pneumoniae, Pseudomonas aeruginosa, various serogroups of Escherichia coli. Thus, providing an immunostimulating effect on the body.

Indications for use

Liquid Pyobacteriophage is prescribed:

• for the treatment and prevention of purulent, inflammatory, gastrointestinal diseases;
• for peritonitis, pleurisy, osteomyelitis, mastitis, purulent wounds and skin lesions;
• for the treatment of sore throats, stomatitis, otitis, sinusitis, pleurisy and pneumonia;
• for pancreatitis, gastroenterocolitis, cholecystitis, dysbacteriosis;
• for the treatment of cystitis, endometritis, colpitis, pyelonephritis;
• with suppuration of the cornea, conjunctivitis;
• for omphalitis, pyoderma, enteritis, various dysbacteriosis, septicemia, septicopyemia.

Contraindications

Doesn't have it.

Side effects

Not registered.

Instructions for Pyobacteriophage Polyvalent purified (Method and dosage)

According to the instructions for use of Pyobacteriophage Polyvalent, enemas, lotions and irrigations are made with the drug. It is also possible to use the drug intracavitary and orally.

Frequency of application 1-3 times a day. The course usually lasts from 5 to 15 days.

For the treatment of pyelonephritis, 5-20 ml are prescribed orally, in 3 doses.

How to give it to a child?

If uncontrollable vomiting occurs in children under one year of age, you can additionally administer the drug through a tube, 3-5 ml every day. The course lasts 5-7 days.

For the treatment of omphalitis and pyoderma in newborns, the medicine can be used in the form of applications, twice a day. The course of piopolyvalent bacteriophage ranges from 5 days to a week.

Overdose

No cases of overdose have been reported.

Interaction

In parallel with treatment with the drug, you can use other anti-inflammatory and antibacterial agents.

Terms of sale

No recipe needed.

Storage conditions

Temperature from 2 to 8 degrees. The shelf life at temperatures up to 25 degrees is reduced to one month. Use immediately after opening. If flakes appear, the solution is not homogeneous, or after the expiration date, the Bacteriophage cannot be used.

Best before date

24 months.

Analogs

Analogues: Piobacteriophage, Piobacteriophage Complex liquid, Piopolyphage, Sextaphage.

Complex Bacteriophage and Polyvalent Pyobacteriophage

The only difference between Complex Pyobacteriophage and Polyvalent is that the latter does not contain enterococcus phagolysate. The drugs have a common manufacturer.

Reviews for Pyobacteriophage Polyvalent purified

Reviews from doctors are good. It is used by surgeons for postoperative wound treatment, pediatricians, gynecologists and urologists. Some believe that the drug is more effective and safe to use than antibiotics.

The reviews on the forums are very good. Many have used the drug and were satisfied with the results. Bacteriophage is especially effective for children due to the absence of side effects; newborns are often allergic to antibiotics.

Price of Polyvalent Pyobacteriophage, where to buy

The price of Pyobacteriophage Polyvalent purified in Ufa is about 650 rubles.

You can buy the product in Moscow for 700 rubles, for 4 ampoules of 20 ml each. Sometimes the product may be called PIOpolyvalent Bacteriophage.

NOTE! Information about medications on the site is for reference and general information, collected from publicly available sources and cannot serve as a basis for making a decision on the use of medications in the course of treatment. Before using the drug Polyvalent Pyobacteriophage, be sure to consult with your doctor.

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Complex bacteriophage: instructions for use, analogues and reviews

Diseases of bacterial etiology are most often treated with antibacterial drugs that have a wide spectrum of action. To selectively destroy pathogenic agents, it is recommended to use bacteriophages. Such drugs have many advantages compared to other medications. A complex bacteriophage is a medicine that contains several types of bacteriophages. Let's take a closer look at the mechanism of action and scope of application of this medicine.

What are bacteriophages?

Each ailment requires specific treatment. To choose the right method of therapy, it is important to determine the type of pathogen. To combat bacterial pathologies that are characterized by severe course and consequences, doctors often prescribe bacteriophages. These drugs are viruses beneficial to the human body that use harmful bacteria to reproduce and continue their life activity. Moreover, they have a negative effect only on pathogenic microorganisms and do not affect the functioning of organs and systems.

Unlike antibiotics, bacteriophages do not destroy beneficial microflora and do not cause the development of dysbacteriosis. The drugs can be taken on a long-term basis and not be afraid of the emergence of resistance of pathogenic microorganisms to the active ingredients.

In pediatric practice, polyvalent bacteriophage is often used. Reviews (for children the medicine is prescribed after diagnosis) from specialists confirm the effectiveness of the drug, provided that the type of pathogen is accurately determined. To do this, before starting therapy, it is necessary to undergo laboratory diagnostics. Bacteriophages are considered to be as powerful drugs as antibiotics.

Country of origin

Product group

Medical immunobiological preparation (MIBP) - bacteriophage

Release forms

• Solution for oral, local and external use, 100 ml bottle - 1 piece per pack. Solution for oral, local and external use, 20 ml bottle - 4 pcs per pack.

Description of the dosage form

• The bacteriophage is a transparent yellow liquid of varying intensity with a specific taste of the nutrient medium, without bitterness; , Solution for oral and topical use Solution for oral, local and external use

pharmachologic effect

Special conditions

Compound

• a mixture of sterile filtrates of phagolysates of bacteria Staphylococcus, Streptococcus, Enterococcus, Proteus (P. vulgaris, P. Mirabilis), Pseudomonas aeruginosa, enteropathogenic Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca a mixture of sterile filtrates of phagolysates of staphylococci, streptococci, enterococci, Proteus, Klebsiella (pneumonia and oxytoca), Pseudomonas aeruginosa and Escherichia coli 20 ml Preservative: quinosol 0.0001 g/ml

Pyobacteriophage indications for use

• Treatment and prevention of purulent-inflammatory and intestinal diseases caused by staphylococci, enterococci, streptococci, Pseudomonas aeruginosa, Klebsiella, pathogenic Escherichia coli of various serogroups, Proteus for internal, rectal and external use. - diseases of the ear, throat, nose, respiratory tract and lungs - inflammation of the sinuses, middle ear, sore throat, pharyngitis, laryngitis, tracheitis, bronchitis, pneumonia, pleurisy; -surgical infections - wound suppuration, burns, abscess, phlegmon, boils, carbuncles, hydroadenitis, panaritium, paraproctitis, mastitis, bursitis, osteomyelitis; -urogenital infections - urethritis, cystitis, pyelonephritis, colpitis, endometritis, salpingoophoritis; - post-traumatic conjunctivitis, keratoconjunctivitis, purulent corneal ulcers and iridocyclitis; -enteric infections - gastroenterocolitis, cholecystitis, dysbacteriosis; -generalized septic diseases; - purulent-inflammatory diseases of newborns - omphalitis, pyoderma, conjunctivitis, gastroenterocolitis, sepsis, etc.; -others