Detailed description of "Eufillin" and methods of its use. Eufillin in children is an unsafe drug for home use

Directions for use and doses

Inside, 1 tablet 3-4 times a day.

Storage conditions for the drug Eufillin

Keep out of the reach of children.

Shelf life of the drug Eufillin

Do not use after the expiration date stated on the package.

Instructions for medical use

Eufillin
Instructions for medical use- RU No. LSR-000883/09

date last change: 24.05.2016

Dosage form

Solution for intravenous administration.

Compound

Active substance:

Aminophylline (aminophylline) (calculated on dry matter) – 24.0 mg

Excipients:

Water for injection – up to 1 ml.

Description of the dosage form

Transparent, colorless or yellowish liquid.

Pharmacological group

Bronchodilator.

Pharmacodynamics

The drug inhibits phosphodiesterase, increases the accumulation of cyclic adenosine monophosphate in tissues, and blocks adenosine (purine) receptors; reduces the entry of Ca2+ through the channels of cell membranes, reduces contractile activity smooth muscles. Relaxes the bronchial muscles, relieves bronchospasm, increases mucociliary clearance, stimulates contraction of the diaphragm, improves the function of the respiratory and intercostal muscles, stimulates the respiratory center, increases its sensitivity to carbon dioxide and improves alveolar ventilation, which ultimately leads to a decrease in the severity and frequency of apnea episodes. By normalizing respiratory function, it helps saturate the blood with oxygen and reduce the concentration of carbon dioxide. Strengthens ventilation of the lungs in conditions of hypokalemia.

It has a stimulating effect on the activity of the heart, increases strength and heart rate, increases coronary blood flow and myocardial oxygen demand. Reduces the tone of blood vessels (mainly those of the brain, skin and kidneys). Has a peripheral venodilating effect, reduces pulmonary vascular resistance, lowers pressure in the pulmonary circulation. Increases renal blood flow, has a moderate diuretic effect. Expands extrahepatic biliary tract.

Stabilizes membranes mast cells, inhibits the release of mediators of allergic reactions.

Inhibits platelet aggregation (suppresses platelet activating factor and prostaglandin E2, increases the resistance of red blood cells to deformation (improves the rheological properties of blood), reduces thrombus formation and normalizes microcirculation.

It has a tocolytic effect, increases the acidity of gastric juice. When used in large doses has an epileptogenic effect.

Pharmacokinetics

Bioavailability for liquid dosage forms– 90-100%. TCmax with intravenous administration of 0.3 g – 15 min, Cmax value – 7 µg/ml. The volume of distribution is in the range of 0.3-0.7 l/kg (30-70% of “ideal” body weight), with an average of 0.45 l/kg. Communication with plasma proteins in adults – 60%, in newborns – 36%, in patients with liver cirrhosis – 36%. Penetrates into breast milk (10% of the dose taken), through the placental barrier (the concentration in the fetal blood serum is slightly higher than in the maternal serum).

Aminophylline exhibits bronchodilating properties in concentrations of 10-20 mcg/ml. Concentrations above 20 mg/ml are toxic. The stimulating effect on the respiratory center is realized at a lower content of the drug in the blood - 5-10 mcg/ml.

Metabolized at physiological values pH with the release of free theophylline, which is further metabolized in the liver with the participation of several cytochrome P450 isoenzymes. As a result, 1,3-dimethyluric acid (45-55%) is formed, which has pharmacological activity, but is 1-5 times inferior to theophylline. Caffeine is an active metabolite and is formed in small quantities, with the exception of premature newborns and children under 6 months, in whom, due to an extremely long half-life of caffeine, its significant accumulation in the body occurs (up to 30% of that for aminophylline).

In children over 3 years of age and in adults, the phenomenon of caffeine accumulation is absent.

T1/2 in newborns and children under 6 months – more than 24 hours; in children over 6 months – 3.7 hours; in adults – 8.7 hours; for “smokers” (20-40 cigarettes per day) – 4-5 hours (after quitting smoking, pharmacokinetics normalize after 3-4 months); in adults with COPD, pulmonary heart disease and pulmonary heart failure - over 24 hours. Excreted by the kidneys. In newborns, about 50% of theophylline is excreted unchanged in the urine versus 10% in adults, which is associated with insufficient activity liver enzymes.

Indications

Asthmatic status ( additional therapy), apnea of ​​newborns, disorder cerebral circulation by ischemic type (in the composition combination therapy), left ventricular failure with bronchospasm and respiratory failure of the Cheyne-Stokes type, edematous syndrome of renal origin (as part of complex therapy).

Contraindications

Hypersensitivity to the drug, as well as to other xanthine derivatives: caffeine, pentoxifylline, theobromine. Expressed arterial hypotension or hypertension, paroxysmal tachycardia, extrasystole, myocardial infarction with disturbances heart rate, epilepsy, increased convulsive readiness, hypertrophic obstructive cardiomyopathy, thyrotoxicosis, pulmonary edema, severe coronary insufficiency, hepatic or renal failure, hemorrhagic stroke, retinal hemorrhages, recent history of bleeding, lactation period.

Carefully:

Pregnancy, neonatal period, elderly age(over 55 years), uncontrolled hypothyroidism (possibility of cumulation), widespread vascular atherosclerosis, sepsis, prolonged hyperthermia, prostate adenoma. The drug is not recommended for intravenous administration to children under 14 years of age (due to possible side effects).

Directions for use and doses

In emergency situations, adults are administered intravenously slowly (over 4-6 minutes) 5-10 ml of the drug (0.12-0.24 g), which is pre-diluted in 10-20 ml of 0.9% sodium chloride solution.

For status asthmaticus, intravenous drip administration is indicated - 720-750 mg.

Higher doses for adults intravenously - single 0.25 g, daily 0.5 g.

Higher doses for children intravenously - single 3 mg/kg, daily - up to 3 months - 0.03-0.06 g, from 4 to 12 months - 0.06-0.9 g, from 2 to 3 years 0 .09-0.12 g from 4 to 7 years – 0.12-0.24 g, from 8 to 18 years – 0.25-0.5 g.

Side effects

From the central nervous system: dizziness, headache, insomnia, agitation, anxiety, irritability, tremor.

From the heart side vascular system: palpitations, tachycardia (including in the fetus when taken by a pregnant woman in the third trimester), arrhythmias, decreased blood pressure, cardialgia, increased frequency of angina attacks.

Allergic reactions: skin rash, itchy skin, fever.

Others: chest pain, tachypnea, flushing, albuminuria, hematuria, hypoglycemia, increased diuresis, increased sweating.

Side effects decrease with decreasing dosage of the drug.

Local reactions: y density, hyperemia, pain at the injection site.

Overdose

Symptoms: loss of appetite, gastralgia, diarrhea, nausea, vomiting (including blood), gastrointestinal bleeding, tachypnea, facial skin flushing, tachycardia, ventricular arrhythmias, insomnia, motor agitation, anxiety, photophobia, tremor, convulsions. In case of severe poisoning, they may develop epileptoid seizures(especially in children without any warning signs), hypoxia, metabolic acidosis, hyperglycemia, hypokalemia, decreased blood pressure, necrosis skeletal muscles, confusion, renal failure with myoglobinuria.

Treatment: drug withdrawal, forced diuresis, hemosorption, plasma sorption, hemodialysis (low effectiveness), symptomatic therapy (including metoclopramide and ondansetron - for vomiting). If convulsions occur, maintain airway patency and administer oxygen therapy. To stop a seizure - intravenous diazepam 0.1-0.3 mg/kg (but not more than 10 mg). Barbiturates should not be used. At severe nausea and vomiting - hemodialysis is recommended.

Interaction

Pharmaceutically incompatible with acid solutions. Increases the likelihood of developing side effects GCS, MCS (hypernatremia), means for general anesthesia(increases the risk of ventricular arrhythmias), drugs that excite the central nervous system (increases neurotoxicity). Rifampicin, phenobarbital, phenytoin, isoniazid, carbamazepine, sulfinpyrazone, aminoglutethimide, oral estrogen-containing contraceptives and moracizine, being inducers of microsomal oxidation, increase the clearance of aminophylline, which may require an increase in its dose. When used simultaneously with macrolide antibiotics, lincomycin, allopurinol, cimetidine, isoprenaline, enoxacin, small doses of ethanol, disulfiram, fluoroquinolones, recombinant interferon alpha, methotrexate, mexiletine, propafenone, thiabendazole, ticlopidine, verapamil and with influenza vaccination, the intensity of action of aminophylline may increase, which may require a reduction in its dose. Enhances the effect of beta-adrenergic stimulants and diuretics (including by increasing glomerular filtration), reduces the effectiveness of Li+ drugs and beta-blockers.

Compatible with antispasmodics, do not use in combination with other xanthine derivatives. Prescribe with caution simultaneously with anticoagulants.

special instructions

Use caution when consuming large amounts of caffeine-containing foods or drinks during treatment. Before administration, the solution must be warmed to body temperature. Elderly patients are recommended to reduce the dose of the drug due to its slow elimination from the body. Smoking patients are advised to increase the dose due to the accelerated elimination of the drug from the body.

Release form

Solution for intravenous administration 24 mg/ml.

Ampoules of 5 ml and 10 ml. 10 ampoules per cardboard pack along with instructions for use. 5 ampoules per blister pack. 1 or 2 blister packs per cardboard pack along with instructions for use. An ampoule knife or scarifier is inserted into each pack. When packaging ampoules with a break point or ring, do not insert an ampoule knife or scarifier.

Storage conditions

In a dry place, protected from light, at a temperature not exceeding 30°C.

Keep out of the reach of children.

Best before date

3 years. Do not use after the expiration date stated on the packaging.

Conditions for dispensing from pharmacies

Dispensed by prescription.

R N002436/01 dated 2008-07-17
Eufillin - instructions for medical use - RU No. LP-003432 dated 2016-02-02
Eufillin - instructions for medical use - RU No. LSR-004120/09 dated 2013-08-15
Eufillin - instructions for medical use - RU No. LSR-005887/08 dated 2008-07-23
Eufillin - instructions for medical use - RU No. LS-000590 dated 2017-11-10
Eufillin - instructions for medical use - RU No. LSR-003895/07 dated 2007-11-19
Eufillin - instructions for medical use - RU No. LSR-002209/07 dated 2007-08-15
Eufillin - instructions for medical use - RU No. LS-000371 dated 2011-10-13
Eufillin - instructions for medical use - RU No. LS-001569 dated 2011-03-18
Eufillin - instructions for medical use - RU No. LS-002028 dated 2011-10-14
Eufillin - instructions for medical use - RU No. LS-000371 dated 2005-06-10
Eufillin - instructions for medical use - RU No. LSR-000883/09 dated 2016-05-24
Eufillin - instructions for medical use - RU No. LS-001731 dated 2017-11-29

Synonyms of nosological groups

Bronchopulmonary diseases are among the most common not only among the adult population of the planet, but also among children of almost any age. Treatment of respiratory diseases has already formed into an entire branch of medicine. One of the favorite drugs that has an invariable effect is “Euphyllin” (euphyllini). It has pronounced activity, helps fight pulmonary insufficiency, relieves cough. "Eufillin" is prescribed to children, observing some important precautions and restrictions.

The use of Eufillin has become widespread due to its pharmacokinetic properties. The active ingredient taken as a basis is theophylline. Internationally pharmaceutical market known as aminophylline. It has a pronounced bronchodilator effect. What does it mean?

The main effect of the drug is that, through complex chemical interactions, the drug reduces the motor and contractile activity of smooth muscles.

Of course, this applies not only to bronchi of different diameters, but also to blood vessels, the liver, the uterus, and the stomach. At the same time, aminophylline increases the amount of blood that passes through the kidneys, which contributes to an increase in diuresis.

The effect on the respiratory tract consists of the following steps:

A decrease in smooth muscle tone occurs due to a decrease in the supply of calcium ions through cell membranes due to blocking purine receptors. Relaxation of the bronchi is necessary for the free passage of mucus and improved respiratory activity.

The diaphragm begins to actively move, which is an auxiliary mechanism for ventilation of the respiratory system. At the same time, the contractile activity of the intercostal muscles increases. They contribute to the full opening of air flow paths.

Due to activation muscle fibers the corresponding center in the brain is indirectly stimulated - the respiratory rate increases.

"Eufillin" is as relevant for children as for adult patients, but its use is significantly limited due to some characteristics of childhood.

The use of the drug is not limited only to the treatment of diseases of the bronchi and lungs. "Eufillin" and its analogues are used in complex treatment due to the following properties:

• ​stimulate cardiac activity;
• ​reduce the tone of blood vessels carrying blood to the brain and kidneys;
• reduce the formation of blood clots in vessels of different sizes;
• improve the rheological properties of blood;
• ​increase emissions of hydrochloric acid in the stomach.

It can be prescribed as a component of therapy for edema syndrome of renal origin.

Analogues of the drug

A large number of medicines on the pharmaceutical market allows the patient and the doctor to choose exactly the drug that will provide the maximum, necessary action. At the same time, it will be available for purchase at a price, and it can be easily purchased in a specific locality. Many companies produce synthesized analogues of the original "Eufillin", which are based on contain the same active ingredients.

In the pharmacy you can find medicines with the active element “theophylline” as a base, but each has its own commercial name. For example, drugs produced in India, Slovenia, and Ukraine are widely represented: Teopek, Theotard, Theophylline, Neophylline, Unicontin. They are available in the form of tablets with different concentrations and dosages, and solutions for injection.

Indications for use of "Eufillin" in children

IN childhood There are a number of serious restrictions on the use of Eufillin precisely because of such a diverse spectrum of influence. Children under three months are not subject to therapeutic effects by this means. In the age interval between one and three years, it is preferable to use aminophylline treatment in the form of inhalations. Children under six years of age are prescribed electrophoresis with aminophylline; for older children, the drug is administered intravenously.

Any diseases respiratory system with a spastic component, cough, difficulty breathing are indications for prescribing aminophylline:

• bronchitis with asthma-like attacks;
• obstructive bronchitis;
• emphysema;
• acute laryngitis with spastic attacks;
• ​swelling of the airways at any level;
• bronchial asthma;
• pneumonia.

In addition to the above diagnoses, it is used as a palliative in the treatment of cerebrovascular insufficiency, diseases of cardio-vascular system, spastic conditions of smooth muscles of other internal organs.

Treatment of infants up to one year

A child under three months of age cannot be treated with Eufillin. And even at this age, the use is strictly limited, only in case of absolute ineffectiveness of other bronchodilators. If there is a threat of pulmonary edema for a child of several months, as well as bronchospasm, acute hypoxia, then the drug is prescribed. Its dose is selected very carefully, and the doctor monitors the body’s reaction and the result obtained around the clock.

Newborn babies cannot take electrophoresis, tablets are effective for obvious reasons. All medications are administered to them intravenously, through droppers. The calculation of the amount to relieve an acute condition is based on six milligrams per 1 kilogram of the baby’s body weight. After the threat of hypoxia disappears, the doctor can adjust the dose:

• 3 - 6 months of age: multiply the number of weeks by 0.07 and add 1.7 mg;
• age 6 - 12 months: weeks multiply by 0.05 and add 1.25 mg.

The frequency of injections in the first half of life is up to three times a day. Children aged six months and older, if necessary, are allowed to administer Eufillin no more than four times a day.

Young patients are very sensitive to drugs of this type. A reaction to treatment may include convulsions and respiratory arrest, so the doctor monitors the condition of such patients especially carefully.

Treatment of young children

In the second year of life children's body It’s already stronger, but you shouldn’t lose your vigilance. The method for selecting the correct, optimal dose remains in force and cannot be deviated from. It is preferable to choose the route of entry of “Eufillin” into the body by injection, drip. This allows you to protect against unwanted side effects of rapid administration.

The instructions for calculating doses take into account not only the patient’s age, but also the degree of development of the process: acute or chronic. So, for children from one to three years old, the amount of the drug per kilogram of body weight at acute illness should not exceed 5 mg and taken orally up to 4 times a day. Children with chronic forms pulmonary pathologies, it is recommended to prescribe a dose of no more than 4 mg per kilogram with the same frequency of administration. Children from three to five years old can receive the medicine in an amount of 4 to three milligrams, depending on the severity of the disease, with a frequency of administration up to four times a day.

The maximum daily amount is limited to 7 mg per kilogram of body weight for a single dose and no more than fifteen milligrams per kilogram per day. These doses can be administered through a therapeutic enema, which is less traumatic for children and adult patients and reduces the possibility of an adverse reaction.

Self-treatment of small children with Eufillin is unacceptable!

Inhalation treatment

One of the valuable qualities of the drug is the ability to provide the necessary effect when different forms receipts, which makes it possible to use "Eufillin" for children, selecting the dosage and method of administration. The most convenient and effective way introductions for children over three years of age are inhalation and iontophoresis, which can be carried out even at home using an Elfor electrophoresis and galvanization apparatus.

The inhalation effect of inhaling “Eufillin” in a vapor state occurs quickly. The medicine acts directly in the target organ, which increases the effectiveness of treatment. Modern inhalers allow you to carry out procedures as compactly as possible, with the necessary frequency and efficiency.

For example, an inhalation “Nebulizer” can be portable, which makes it possible to inhale a therapeutic mixture with “Eufillin” directly in a hospital ward or at home. One of the recipes for preparing a solution with “Eufillin” for inhalation is as follows:

• 100 ml of water must be mixed with the contents of one ampoule of diphenhydramine solution and the same amount of “Eufillin”, the concentration percentage of which is 2%;
• inhalation is carried out no more often than with a break of up to 6 hours;
• The patient's neck is in a fixed position for maximum air flow.

After inhalation medicinal mixture, the child should spend at least 30 minutes in a calm state. We remind you once again that self-prescription of Eufillin is unacceptable!

When is Eufillin prescribed in ampoules?

Any solutions for parenteral, rectal or inhalation administration are indicated for acute conditions, For quick relief life-threatening attack or consequences. Also, drugs in ampoules are preferable if there are violations from gastrointestinal tract, the patient is in unclear consciousness, inadequate. Another indication for use injection forms serves the elderly, children's age.

Features of treatment with a tablet drug

Conscious age of seven years and older allows taking tablet forms. Instructions for the use of tablets for children have been developed for aminophylline. Here, too, the doctor adheres to a strict prescribing regimen, which contains the following instructions:

• A child’s weight up to 30 kg requires prescription of more than 20 mg per 1 kg per day;
• ​from three to seven years maximum dose is 100 mg per day.

The tablets should be taken with plenty of liquid, preferably plain water, to prevent kidney complications.

Compress with Eufillin

There are recommendations to put it on the back small child a compress containing a solution of Eufillin, dimexide, and no-shpa to relieve a strained cough. There is no reliable information about its effectiveness, but you can get an allergic reaction. It is best to consult a doctor to avoid undesirable consequences such treatment.

Contraindications and side effects

There is a list absolute contraindications to prescribe treatment with Eufillin not only for children, but also for adults:

• epileptic activity;
• ​convulsive syndrome;
• renal failure;
• ​acute and chronic liver failure;
• ​mental disorders.

The following pathologies are relative limitations:

• organic disorders of the cardiovascular system;
• diseases of the gastrointestinal tract with high acidity.

In addition to restrictions on use and contraindications, there is a list of possible side effects:

• allergic reactions various manifestations: from skin rashes to Quincke's edema;
• gastrointestinal disorders;
• attacks of palpitations, tachycardia;
• vegetative reactions.

Children are susceptible to adverse reactions from the nervous system. They may be agitated, have trouble sleeping, be capricious, and react to the drug with seizures.

Interaction with other drugs and overdose

Antimicrobial agents potentiate the effect of Eufillin; this must be taken into account when calculating the dose. Antidiarrheal drugs reduce the absorption of the drug and its effectiveness.

Steroid drugs greatly increase the possibility of adverse reactions with simultaneous use of a bronchodilator. That is why only a doctor decides the issue of treatment with Eufillin, its dose and frequency of administration, especially for children.

Symptoms of drug poisoning, convulsions, respiratory arrest, hypercapnia are emergency, which requires urgently stopping Eufillin, rinsing the stomach, and administering antidotes.

Photo of the drug

Latin name: Euphyllin

ATX code: R03DA05

Active substance: INN: Aminophylline

Manufacturer: OJSC “Borisov Plant” medical supplies”, Republic of Belarus OJSC “Biosintez”, OJSC “Pharmstandard-Leksredstva”, OJSC “Organika”, Russia LLC “Niko”, LLC “Pharmaceutical Company “Zdorovye””, PJSC “Pharmaceutical Firm “Darnitsa”, Ukraine

Description update: 09.10.17

Eufillin is medicinal product, which has bronchodilator properties. Available in the form of tablets and solution for injection.

Pharmacological action of Eufillin

In accordance with the instructions for Eufillin, active active ingredient The drug in all forms of release is theophylline. The excipients included in the tablets are potato starch and calcium stearate. Additional components of the solution are sodium hydroxide, sodium acetate trihydrate, water for injection.

Euphyllin is a xanthine derivative. The drug inhibits phosphodiesterase, increases the accumulation of cyclic adenosine monophosphate in tissues, and inhibits adenosine receptors. When using Eufillin, the bronchial muscles relax and mucociliary clearance increases, which leads to contraction of the diaphragm and improved contraction of the intercostal and respiratory muscles. The drug activates the work respiratory center, increases its sensitivity to carbon dioxide and increases alveolar ventilation, thereby reducing the frequency and severity of apnea episodes.

Eufillin normalizes respiratory function, helps reduce carbon dioxide concentrations and saturate the blood with oxygen.

When used, Eufillin stimulates the activity of the heart, strengthens and increases the number of heart contractions, increases the myocardial oxygen demand and coronary blood flow. The medicine reduces the tone of the blood vessels of the kidneys, skin and brain. The drug has a tocolytic effect, which increases the acidity of gastric juice. In high concentrations it has an enileptogenic effect.

Theophylline, the active ingredient of Euphyllin, is well and quickly absorbed from the gastrointestinal tract. Has high bioavailability. Penetrates through the placental barrier into breast milk. Metabolized in the liver and excreted through the kidneys.

Indications for use of Eufillin

Indications for Eufillin are:

• Bronchial asthma;
• Chronic obstructive pulmonary disease;
• Sleep apnea;
• Renal blood flow disorders;
• "Pulmonary" heart;
• Cerebral vascular crises;
• Ischemic stroke;
• Pulmonary hypertension;
• Chronic obstructive bronchitis;
• Emphysema.

Methods of use and dosage of Eufillin

For strokes and acute attacks bronchial asthma Eufillin according to the instructions is administered slowly in a stream over 4-6 minutes at a dosage of 0.12-0.24 g (5-10 ml of 2.4% product must first be diluted in 10-20 ml of sodium chloride solution). If dizziness, palpitations or nausea develop, slow down the administration or switch to drip administration. To do this, 10-20 ml of Euphyllin are diluted in 100-150 ml of sodium chloride solution and administered 30-50 drops per minute. A single dose of medication for children over 14 years of age is 2-3 mg/kg.

The drug is administered intravenously under the control of heart rate, respiration and blood pressure.

For rectal use Eufillin in microenemas, 10-20 ml of the substance is diluted with 20-25 ml of warm water.

Maximum single dosage solution at intravenous administration for adults should not exceed 0.25 g, and the daily dose should not exceed 0.5 g. In intensive care conditions with severe cases it is possible to increase the single dose of Eufillin according to indications.

Maximum single dose drug for children rectally and intramuscularly – 7 mg/kg, intravenously – 3 mg/kg.

A single dose of Eufillin tablets for adults is 150 mg, the frequency of administration is 1-3 times a day. Children are prescribed 7-10 mg/kg per day in 4 divided doses.

The duration of treatment is from several days to several months, depending on the tolerability of the drug and the course of the disease.

Side effects of Eufillin

Reviews of Eufillin report that the drug can cause adverse reactions from the body:

• Central nervous system: tremor, irritability, anxiety, agitation, insomnia, headaches, dizziness;
• Cardiovascular system: angina pectoris, arterial hypotension, cardialgia, arrhythmia, tachycardia, palpitations;
• Digestive system: diarrhea, exacerbation of peptic ulcer, heartburn, gastroesophageal reflux, nausea, vomiting, gastralgia;
• Allergic reactions: fever, itching, skin rash;
• Other: diuresis, hypoglycemia, hematuria, albuminuria, tachypnea, chest pain.

Contraindications to the use of Eufillin

The following are not indications for Eufillin:

• Hypersensitivity to the components of the drug;
• Epilepsy;
• Gastritis with high acidity;
• Peptic ulcer of the stomach and duodenum;
• Tachyarrhythmia;
• Arterial gopo- or severe hypertension;
• Hemorrhagic stroke;
• Children under 14 years of age;
• Retinal hemorrhage.

With caution, Eufillin, according to reviews and instructions, is prescribed to people with severe coronary insufficiency, widespread vascular atherosclerosis, frequent ventricular extrasystole, hypertrophic obstructive cardiomyopathy, renal or liver failure, increased convulsive readiness, prolonged hyperthermia, prostatic hyperplasia, gastroesophageal reflux, as well as women during pregnancy and lactation.

Overdose of Eufillin

Reviews of Eufillin note that in case of an overdose of the drug, generalized convulsions, photophobia, insomnia, ventricular arrhythmias, tachycardia, facial hyperemia, tachypnea, nausea, vomiting, diarrhea, and anorexia are observed. During development listed symptoms it is necessary to discontinue the drug and actively stimulate its elimination from the body.

Eufillin's analogs

By therapeutic properties And active substance analogues of Eufillin are Aminocardol, Diafillin, Novofillin, Sintofillin, etc.

Additional Information

Eufillin is not combined with acid solutions, glucose, indirect coagulants, calcium chloride, dibazole and alkaloid salts.

The drug is compatible with antispasmodics. It potentiates the effect of diuretics.

The instructions for Eufillin indicate that the tablets and solution should be stored in a dark, dry, cool place out of reach of children.

Dispensed from pharmacies with a doctor's prescription.

The shelf life of Eufillin is 36 months.