Distilled water for injection. Distilled sterile water. Water for injection: composition, description and release form of the product

Water for injection is a special sterile liquid that has no color, taste or smell. Water is extremely important for humans, because it is what maintains the normal course of metabolic processes. Therefore, for injections it is often necessary that a solution of the drug be prepared in the required dosage. This is why this water is used, standardized according to several pharmacopoeial articles (hereinafter referred to as FS). Let's figure out what it is and what it is theoretically needed for.

When is it used?

This water for injection is used either as a carrier or as a diluent in the preparation of infusion or injection solutions from:

1. powders;
2. dry substances for preparing injections;
3. concentrates for preparing infusions;
4. lyophilisates;
5. infusion and injection solutions with inappropriate concentrations, and so on.

That is, water for injection is needed to dissolve or dilute drugs (depending on what requirements their instructions impose) before they are administered intramuscularly, intravenously or subcutaneously. The form of release of such liquid is ampoules. The shape is almost always the same, but the volume can vary.

Water for injection is not the same as saline solution. If the saline solution is sodium chloride, then the water for injection is distilled/sterile water, previously prepared in a special way.

Here is some more information about this water:

Composition and creation

Water for injection is water that has been purified from any biological or chemical impurities, including:

• gases;
• salt;
• pyrogenic substances;
• microorganisms;
• any other form of microimpurities.

Such liquid is purified using the reverse osmosis method, that is, a special technology for separating organic compounds. Also, such water can be distilled so that its composition is certainly pure. In order for it to be distilled, it is first transferred into steam and then returned back to the liquid state. All these procedures are carried out in compliance with the highest hygienic requirements, everything takes place in a special aseptic unit, where it is unacceptable to carry out any other actions not directly related to the distillation of water. That’s why this water always comes out sterile. Such application requirements are imposed by the FS, and the requirements for the use of the FS must be complied with. It is also necessary to respect the expiration date; if the expiration date is violated, the effects may be negative.

Characteristics

Water for injection necessarily has a number of characteristics (they are required by the FS; in addition to the FS, distilled/sterile water is standardized according to GOST), which distinguish it from any other water. Here are the parameters and requirements that must be observed:

• pH value cannot be higher than 5.0-7.0;
• there cannot be any amount of reducing substances, calcium, chlorides, nitrates, carbon dioxide, or heavy metals;
• According to the Federal Law, one milliliter of water cannot contain more than one hundred microorganisms;
• water must certainly be pyrogen-free;
• ammonia content must be standardized;
• antimicrobial type substances cannot be present;
• no additives may be present at all.

Application

Instructions for use of this liquid depend on which medications it is used with. The requirements are imposed precisely by the medicine that is diluted in this water, therefore it is necessary to use the instructions for use that come with this particular medicine. The dosage that will be used to dilute these medications must be indicated there.

If we talk about the requirements common to all medicines, it is that water for injection must be used under aseptic conditions, so that there is not the slightest risk that it will not be sterile enough.

Interaction

When water for injection is mixed with other drugs, it is necessary to visually monitor compatibility. If you do not do this, you may miss pharmaceutical incompatibilities.

It is important to remember that if the requirements for the drug indicate the need to use a different type of liquid, for example, a special saline solution must be used, then drinking water is unacceptable. It also cannot be used for external use; the requirements for them are also completely different.

Suitability

The shelf life of such water can be up to three years. When the expiration date has expired, this water should not be consumed. It is important to remember that the expiration date is for storage at an approximate temperature of 2 to 25 ° C without freezing.

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Water for injections.

Pharmacotherapeutic group

Solvent.
ATX code- V07AB.

Pharmacological properties

Pharmacodynamics
Water for injection is a means for diluting (dissolving) drugs.
Pharmacodynamic properties are determined by the characteristics of the added drug.
Pharmacokinetics
Not applicable. Water for injection is a means for diluting (dissolving) drugs. Pharmacological properties are determined by the characteristics of the added drug.

Indications for use

Water for injection is used for the preparation under aseptic conditions of solutions of medicinal products that are not subject to further sterilization.

Directions for use and doses

The preparation of drug solutions using water for injection is carried out under aseptic conditions. The amount of water for injection for the purpose of preparing a solution of a particular drug is determined by the instructions for its use or, depending on the situation, by the doctor.

Side effect

Not known. Intravenous injection of water for injection may lead to hemolysis when administered alone. The nature of the drug added will determine the likelihood of any unwanted effects.

Precautionary measures

Water for injection is a hypotonic solution and should not be administered separately. It is not recommended to use water for injection for intravenous administration unless the resulting drug solution is approximately isotonic.
When using the solution as a diluent for a hypertonic solution, it is recommended to use water for injection in the amount necessary to obtain a solution close to isotonic. Hemolysis may develop with the intravenous administration of large volumes of hypotonic solutions prepared using water for injection as a diluent.

special instructions

It is unacceptable to use water for injection in its pure form for intravascular administration due to its low osmotic pressure and the risk of hemolysis.

Impact on the ability to drive vehicles and potentially dangerous mechanisms

The effect on the ability to drive vehicles and potentially dangerous mechanisms is determined by the properties of the dissolved or diluted drug.

Use during pregnancy and lactation

Can be used during pregnancy and lactation.
The risk when used during pregnancy and breastfeeding depends on the nature of the added medicinal product.

Interaction with other drugs

Possible interactions between different drugs are determined by the properties of the drug being dissolved or diluted.
Incompatibility. Water for injection should not be mixed with any other medicinal products unless their compatibility has been established.

Overdose

The development of an overdose if the proposed dosage regimen is followed is unlikely. Hemolysis may develop after intravenous administration of large volumes of hypotonic solutions using water for injection as a diluent. The clinical symptoms of an overdose will be determined by the added drug. In case of accidental overdose, treatment should be stopped and the patient's condition monitored.

Country of origin

Product group

Solvent for the preparation of dosage forms for injections

Release forms

• 10 ampoules of 2 ml in ampoules of colorless neutral glass type I in a box 10 ampoules of 5 ml in a pack of 10 ml - ampoules (10) - cardboard packs. 100 ampoules of 2 ml in plastic containers 2 ml - ampoules (10) - cardboard packs 2 ml - ampoules (5) - cardboard packs. 2 ml - ampoules (10) - cardboard packs. 2 ml - ampoules (5) - contour plastic packages (1) - 5 ml cardboard packs - ampoules (10) - 5 ml cardboard packs - ampoules (10) - cardboard packs. polyethylene ampoules of 2 ml - 10 pieces per pack 10 ampoules of 5 ml per pack Solvent for the preparation of dosage forms for injections - 500 ml in polypropylene bottles Solvent for the preparation of dosage forms for injections of 10 ml in ampoules made of low-density polyethylene or polypropylene - 10 pcs per pack. Solvent for the preparation of dosage forms for injection, 2 ml in ampoules made of low-density polyethylene or polypropylene - 10 pcs per pack. Solvent for the preparation of dosage forms for injection, 5 ml in polymer ampoules. Labels are glued onto polymer ampoules, or label text is applied directly to polymer ampoules using inkjet printing. 100 polymer ampoules with instructions for use are placed in a cardboard pack. Solvent for the preparation of dosage forms for injection, 5 ml in ampoules made of low-density polyethylene or polypropylene - 10 pcs per pack. solvent for the preparation of dosage forms for injection, 5 ml in an ampoule of colorless neutral glass - 10 ampoules per pack 10 ampoules 2 ml pack 10 ampoules 2 ml pack 10 ampoules 5 ml pack 10 ampoules 5 ml

Description of the dosage form

• colorless, transparent, odorless liquid. colorless transparent liquid colorless transparent liquid odorless and tasteless colorless transparent liquid odorless and tasteless. Colorless, transparent, odorless liquid. Transparent, colorless, odorless liquid, transparent, colorless, odorless and tasteless liquid. Transparent, colorless, odorless liquid. Solvent for the preparation of dosage forms for injections and solvent for the preparation of dosage forms for injections

pharmachologic effect

Pharmacokinetics

Special conditions

Compound

• 1 amp. water for injection 2 ml water for injection. 1 amp. water d/i 100% 1 amp. water for injection 5 ml water for injection 2 ml water for injection 5 ml water for injection 10 ml water for injection water for injection 2 ml water for injection 2 ml water for injection 5 ml water for injection 10 ml

Water for injection indications for use

• As a carrier or diluent solution for the preparation of sterile infusion (injection) solutions from powders, lyophilisates and concentrates. It is used for the preparation of sterile solutions intended for subcutaneous, intramuscular or intravenous administration immediately before use. Externally for washing wounds and moistening dressings.

Water for injection contraindications

• Water for injection is not used as a solvent for drugs if another solvent is specified as mandatory for some of them.

Water for injection side effects

• Water for injection cannot be directly administered intravascularly due to low osmotic pressure (risk of hemolysis!).

Drug interactions

Overdose

Storage conditions

• keep away from children
• store in a place protected from light

The human body is susceptible to various kinds of diseases, and therefore may require permanent or temporary treatment. In many cases, a special solution must be used along with medications. The manufacturing principle is to use highly purified water, which has previously undergone a mandatory process of distillation and disinfection.

To do this, the water is heated to 80 °C, which completely prevents the appearance and growth of microorganisms in it. It is cleaned of chlorine impurities and iron content, and goes through a softening process. In pharmaceutical production, pure condensed steam obtained from water distillation is also used.

Water for injection - characteristics

Water for injection is a purified liquid used to dissolve drugs in dosage forms. It has no taste, smell or color. This universal product is for sale in glass ampoules, 10 pieces per box.

Injection water is needed as product of a homogeneous homogeneous mixture for injection and infusion from the following concentrates:

• substances, preparation of infusion;
• medicinal powders;
• dry substance for injection.

Sterile purified and distilled water, which serves exclusively as drug solvent in strictly prescribed doses, according to the instructions for use.

Production and composition of injection liquid

Water for injection, the composition of which, at first glance, is very simple, but at the same time it is subject to certain stages of processing. The main component that needs to be removed from the liquid is hardness salts, thereby forming condensation.

Get this healing mixture reverse osmosis method, in which its complete liberation from organic compounds occurs.

And there is also distillation method. In this case, the treated liquid undergoes special purification and, as a result, it is freed from various impurities:

• Mechanical particles.
• Colloidal elements.
• Dissolved organics and gases.
• Inorganic substances.
• Microorganisms.

Cleansing procedures take place in an aseptic unit, maintaining hygiene conditions at the highest level. The expiration dates of the medication must be observed. Water for injection composition must meet the requirements desalted, purified and softened liquid:

1. Mandatory absence of chlorides, sulfates, calcium nitrates.
2. pH environment from 5.0 to 7.0.
3. Standardized ammonia content.
4. Any additives and antimicrobial substances should be absent.
5. The suspension must be aspirogenic.
6. Absence of any additives.

water for injection forms

Water for injection: instructions for use

Water for injection instructions for use depend on the medications with which this liquid will be used. The dilution requirements will be specified in the instructions for the medication with which the injection base will interact.

The daily dose, as well as recommendations for the administration of drugs, must undoubtedly be regulated. Ignoring the instructions for the medication can lead to disastrous consequences. Mandatory compliance with sterility conditions when administering a diluted medication.

When mixing water with prescribed medications, it is necessary check this mixture for compatibility. This must be done to avoid missing pharmaceutical incompatibilities. Injection liquid cannot be used for intravascular administration.

The use of this mixture is prohibited if saline solution or any other solvent is indicated for the medication. Injections are an important process in human treatment. Inject using a syringe and needle intramuscularly or intravenously necessary medication. And if necessary, dilute the medicine with a special liquid. To do everything correctly, read the instructions for water for injection.

Mode of application

Solutions using injection base and medications must be prepared under aseptic sterile conditions. It is also a mandatory requirement to follow simple rules for working with the ampoule:

There were no adverse reactions, as well as overdoses and contraindications in practice.

Nuances of using injection water and expiration dates

Remember one very important rule: this liquid should never be mixed with oil solutions, ointments and cauterization agents.

The dose and concentration of the mixture are strictly observed. If hemolysis develops, it is prohibited to administer injection fluid.

How much does the injection base cost? The price of this substance is in the range from 29 rubles to 100 rubles, again depending on the manufacturer, in general, it is a very affordable medicine. There is a huge selection of injectable water on the Internet, so it is advisable to compare prices.

Water for injection is stored from two to three years, depending on the manufacturer. After the expiration date, do not use this medication for treatment under any circumstances. Do not freeze during storage; the permissible temperature is somewhere in the range of 5–25 °C. The shelf life of this universal product must be maintained.

Russian name

Latin name of the substance Water for injection

Gross formula

Pharmacological group of the substance Water for injection

Nosological classification (ICD-10)

CAS code

Typical clinical and pharmacological article 1

Characteristic. Sterile, pyrogen-free, colorless, odorless, tasteless, transparent liquid that does not contain chemical, especially toxic, impurities (nitrates, nitrites, chlorides, sulfates, heavy metals, etc.).

Pharmaceutical action. Solvent. In the human body, water is necessary for constant metabolic processes. Under normal conditions, water is excreted through urine, feces, sweat, and breathing. Loss of fluid through sweat, breathing, and feces occurs regardless of fluid administration. Maintaining adequate hydration requires 30-45 ml/kg/day of water in adults, and in children - 45-100 ml/kg, in infants - 100-165 ml/kg. Water for injection is used for the preparation of infusion and injection solutions, providing optimal conditions for the compatibility and effectiveness of substrates and water.

Pharmacokinetics. With the introduction of constantly alternating water and electrolytes, homeostasis is maintained by the kidneys.

Indications. As a carrier or diluent solution for the preparation of sterile infusion (injection) solutions from powders, lyophilisates and concentrates. Used for the preparation of sterile solutions, incl. for subcutaneous, intramuscular, intravenous administration. Externally for washing wounds and moistening dressings.

Contraindications. If another solvent is specified for the preparation of the drug.

Dosing. The dose and rate of administration must comply with the dosage instructions for diluted drugs.

Preparation of drug solutions using water for injection must be carried out under sterile conditions (opening ampoules, filling syringes and containers with drugs).

Interaction. When mixed with other drugs (infusion solutions, concentrates for preparing infusions; injection solutions, powders, dry substances for preparing injections), visual control for compatibility is required (pharmaceutical incompatibility may occur).

Special instructions. Water for injection cannot be directly administered intravascularly due to low osmotic pressure (risk of hemolysis!).

State register of medicines. Official publication: in 2 volumes - M.: Medical Council, 2009. - Volume 2, part 1 - 568 pp.; Part 2 - 560 s.

Interactions with other active ingredients

Trade names