23.06.2020

Potassium iodide solution instructions for use. Potassium iodide - instructions for use, indications, composition, release form, dosage and price Potassium iodide preparations

Eye drops Potassium Iodide is an ophthalmic drug that has an antiseptic effect.

The drug has a pronounced antimicrobial effect on the affected area, and also has an anti-sclerotic effect, due to which all processes of resorption of infiltrates of syphilitic keratitis and hemophthalmos are accelerated.

Composition and release form

Potassium Iodide eye drops – 2% or 3% sterile solution of potassium iodide, intended for instillation into the conjunctival sac.

1 milliliter of the drug contains the active component - potassium iodide in a volume of 20 milligrams for a 2% solution or 30 milligrams for a 3% solution.

Excipients: chlorhexidine diacetate, sodium thiosulfate, sodium chloride, distilled water.

Potassium Iodide eye drops are available in polyethylene bottles with a lid - a 10-milliliter dispenser.

pharmachologic effect

Potassium Iodide eye drops are an ophthalmic drug that have a resorption and anti-sclerotic effect. Accelerates the resorption of hemophthalmos, and also activates the resorption of infiltrates of syphilitic keratitis. Suppresses the growth of fungi.

The effect of the drug on the body:

• increases the concentration of lipoprotein in the blood;
• reduces blood viscosity, and as a result, prevents the development of atherosclerosis;
• dilates the walls of blood vessels.

Potassium Iodide eye drops cannot completely eliminate, but iodine salts significantly calm the symptomatic picture, prevent a decrease in visual acuity, and prevent further spread of the disease.

Pharmacokinetics

After instilling Potassium Iodide eye drops into the conjunctival sac, the active substance of the drug reaches the structures of the eye and nasal cavity, where it is absorbed into the mucous membranes to maximum concentration. The exact distribution is unknown.

It is excreted from the body slowly; the active drug is not metabolized.

Important! During treatment with Potassium Iodide eye drops, you should stop taking other iodine-containing medications.

Indications

Indications for the use of Potassium Iodide eye drops are:

• hemorrhages in the membrane of the eye;
• opacities of the vitreous body of the cornea;
• fungal infections of the conjunctiva;
• fungal infections of the cornea.

Contraindications

The drug should not be used if you have the following diseases:

• nodular goiter and other benign formations in the thyroid gland;
• toxic thyroid adenoma;
• hemorrhagic diathesis;
• nephritis, nephrosis;
• pyoderma, furunculosis, acne;
• hypersensitivity to iodine preparations.

Dosage

Before using the medicine, you must wash your hands with soap, this will prevent possible additional infection.

Note! The exact dosage, as well as the duration of treatment, can only be prescribed by an ophthalmologist. The instructions for use provide the standard dosage. Don't self-medicate!

The standard treatment regimen involves the use of eye drops up to 4 times a day, one or two drops, which are carefully instilled into the conjunctival sac. The duration of therapy cannot exceed two weeks.

Overdose

An overdose can occur with the simultaneous use of iodine-containing drugs orally, as well as with accidental ingestion of Potassium Iodide eye drops.

Signs of acute overdose:

• oral cavity, colored brown;
• bronchitis;
• rhinitis;
• swelling of the vocal cords;
• gastroenteritis;
• anuria (lack of urine);
• bleeding from the urinary tract;
• collapse, in some cases leading to death.

Treatment of overdose consists of gastric lavage with a solution of 1% sodium thiosulfate and starch solution, ingestion of flour gruel, corn, potato, rice or oatmeal thick broth. The patient is prescribed maintenance therapy.

Pregnancy and lactation

The use of Potassium Iodide eye drops by pregnant women is permitted only when alternative drugs are not available. The use of this iodine-containing drug requires constant monitoring of the well-being of the expectant mother and fetus. At the first appearance of side effects, the use of eye drops should be discontinued.

The use of the drug Potassium Iodide by nursing women should be done under the supervision of a pediatrician.

Side effects

The drug Potassium Iodide is well tolerated by patients. Sometimes a slight burning sensation may occur after instillation. Prolonged uncontrolled use of the drug contributes to the development of pronounced side effects - allergic reactions, lacrimation, irritation and redness, swelling of the eyelids. Dermatitis, erythema, and acne may occur.

Interaction with other drugs

Potassium Iodide eye drops should be used with caution while taking medications to eliminate depression, which include lithium salts, potassium-sparing diuretics, and substances that suppress the production of thyroid hormones. You must inform your ophthalmologist about the use of drugs from these groups.

Special instructions and precautions

Before you start taking Potassium Iodide eye drops, you must make sure that there are no benign or malignant neoplasms of the thyroid gland.

An iodine-containing ophthalmic drug should be prescribed with caution to patients with impaired renal function; in such cases, the use of Potassium Iodide eye drops is possible only with periodic monitoring of potassium concentration in the blood.

During pregnancy and lactation, taking the drug is permitted subject to medical supervision.

Storage conditions and periods

Store in a dry place.

The shelf life of unopened packaging is three years. Use the contents of an open bottle within 1 month.

Structural formula

Russian name

Latin name of the substance Potassium iodide

Kalii iodidum ( genus. Kalii iodidi)

Gross formula

KI

Pharmacological group of the substance Potassium iodide

Nosological classification (ICD-10)

CAS code

7681-11-0

Characteristics of the substance Potassium iodide

Inorganic iodine compound.

Colorless or white cubic crystals or white finely crystalline powder with a bitter-salty taste, odorless. It absorbs water well from humid air. Easily soluble in water (1:0.75), alcohol (1:12), glycerin (1:2.5).

Pharmacology

pharmachologic effect- replenishes iodine deficiency, expectorant, antifungal, mucolytic, radioprotective, antithyroid, absorbable.

When entering the body in physiological quantities, iodide normalizes the synthesis of thyroid hormones, triiodothyronine (T 3) and thyroxine (T 4), which is impaired due to iodine deficiency, and normalizes the T 3 / T 4 ratio. In the epithelial cells of the thyroid follicle, under the action of thyroid peroxidase, it is oxidized to elemental iodine, which ensures iodination of tyrosine residues on the side chains of the thyroglobulin molecule with the formation of precursors of thyroid hormones - monoiodotyrosines (MIT) and diiodotyrosines (DIT), with 140 tyrosine residues included in the composition of thyroglobulin, only 1/5 of it is iodized. Under the influence of oxidative enzymes, MIT and DIT condense to form thyronines, the main of which are triiodothyronine (T 3) and thyroxine (T 4). The complex of thyroglobulin with thyronines moves from the colloid to the follicular cell by endocytosis, where it is deposited. The release of thyroid hormones from thyroglobulin occurs in the apical part of the thyrocyte through hydrolysis by lysosomal enzymes. As a result of the hydrolysis of thyroglobulin, a number of compounds are released, incl. triiodothyronine and thyroxine, as well as MIT and DIT. The latter are deiodized inside the gland, and the released iodine is again used for the biosynthesis of hormones.

The administration of a significant excess of iodide (more than 6 mg daily) in hyperthyroidism, according to the feedback principle, leads to the suppression of the synthesis and release of thyroid-stimulating hormone from the pituitary gland, inhibits the synthesis and release of (mainly) thyroid hormones, possibly due to the suppression of proteolysis of thyroglobulin. In addition, iodide reduces vascularization and the size of the thyroid gland, thickens its tissue, prevents hyperplasia of the thyroid gland and restores its size in children and adolescents.

In patients with hyperthyroidism, it quickly causes remission of symptoms, and therefore large doses of iodide are used in the preoperative preparation of patients for resection of the thyroid gland to facilitate thyroidectomy (together with other antithyroid drugs) and during thyrotoxic crisis. The antithyroid effect of iodide is unstable - it lasts only 2-3 weeks and is used to temporarily reduce thyroid function.

The radioprotective effect of iodide is due to the fact that it prevents the thyroid gland from absorbing radioactive isotopes of iodine and protects it from the effects of radiation. When taking potassium iodide simultaneously with exposure to radiation, the protective effect is about 97%; when taken 12 and 24 hours before exposure to radiation - 90% and 70%, respectively, when taken 1 and 3 hours after exposure - 85% and 50%, more than 6 hours - the effect is insignificant.

The expectorant effect is due to the fact that iodide, secreted by the bronchial mucous glands, causes reactive hyperemia of the mucous membrane, helps to liquefy sputum, incl. due to an increase in water content in the secretion, it enhances the function of the ciliated epithelium and increases mucociliary clearance.

There is evidence of the effectiveness of iodide in erythema nodosum and fungal infections.

After oral administration, it is quickly and completely absorbed in the small intestine and distributed in the intracellular space within 2 hours. Accumulates mainly in the thyroid gland (iodide concentration more than 500 mcg/g tissue), as well as in the salivary and mammary glands, and gastric mucosa. Penetrates well through the placenta. It is excreted primarily by the kidneys (trace amounts are determined in urine 10 minutes after administration, 80% of the dose is excreted within 48 hours, the rest within 10-20 days), partially with the secretions of the salivary, bronchial, sweat and other glands.

Application of the substance Potassium iodide

Prevention of iodine deficiency diseases (endemic goiter, etc.) in areas with iodine deficiency, incl. in children, adolescents, pregnant and lactating women, prevention of goiter recurrence after resection of the thyroid gland;

— treatment of goiter and other iodine deficiency diseases in children (including newborns), adolescents and adults;

— hyperthyroidism, preparation for resection of the thyroid gland, thyrotoxic crisis;

- difficult sputum discharge (inflammatory diseases of the upper respiratory tract, bronchial asthma, pulmonary actinomycosis);

- preventing the thyroid gland from absorbing radioactive iodine and protecting against radiation;

- syphilis (resorption of infiltrates in the tertiary period) - auxiliary treatment;

- in ophthalmology: cataracts, opacification of the cornea and vitreous body, hemorrhage in the membranes of the eye, fungal infections of the conjunctiva and cornea;

— in dentistry: inflammatory diseases of the salivary glands, xerostomia.

Contraindications

Hypersensitivity to iodine, pronounced and latent (for doses exceeding 150 mcg/day), hyperfunction of the thyroid gland, toxic thyroid adenoma, nodular goiter and other benign tumors of the thyroid gland (for doses exceeding 300 mcg/day, with the exception of preoperative iodine therapy), Dühring's dermatitis herpetiformis, pulmonary tuberculosis, nephritis, hemorrhagic diathesis, nephrosis, furunculosis, acne, pyoderma.

Restrictions on use

Pregnancy, breastfeeding.

Use during pregnancy and breastfeeding

During pregnancy and breastfeeding, use is possible only in physiological (prophylactic) doses. Use during pregnancy can lead to suppression of thyroid function (hypothyroidism) and an increase in its size in the fetus, and during breastfeeding - to the appearance of a rash and decreased thyroid function in the newborn (at doses above 300 mcg of iodine per day, breastfeeding should be stopped ).

Side effects of the substance Potassium iodide

From the gastrointestinal tract: nausea, vomiting, dyspeptic symptoms, gastralgia, diarrhea.

From the nervous system and sensory organs: anxiety, headache.

Allergic reactions: angioedema, hemorrhages on the skin and mucous membranes, swelling of the salivary glands, urticaria.

Others: changes in thyroid function (hyperthyroidism, hypothyroidism), hyperkalemia, mumps, iodine toxicity (confusion, irregular heartbeats; numbness, tingling, pain or weakness in the arms and feet; unusual lethargy, weakness or heaviness in the legs); iodism (with long-term use, especially in high doses): burning in the mouth or throat, metallic taste in the mouth, increased salivation, sore teeth and gums, redness of the conjunctiva, swelling of the eyelids, rhinitis, fever, arthralgia, acne, dermatitis (exfoliative, etc. .), eosinophilia.

Interaction

The antithyroid effect is enhanced (mutually) by antithyroid drugs. Thyroid-stimulating hormone activates the accumulation of iodine by the thyroid gland, while potassium perchlorate and thiocyanate inhibit it. Taking high doses of iodide concomitantly with potassium-sparing diuretics increases the risk of hyperkalemia and arrhythmia. When taken simultaneously with ACE inhibitors, the risk of developing hyperkalemia also increases, and with lithium preparations - the risk of developing hypothyroidism and goiter.

Overdose

Symptoms of acute overdose: brown staining of the oral mucosa, rhinitis, bronchitis, gastroenteritis, swelling of the vocal cords, bleeding from the urinary tract, anuria, collapse (even death).

Treatment of acute overdose: gastric lavage with a starch solution (until the blue color of the solution disappears) and 1% sodium thiosulfate solution, taking flour gruel, corn, potato, rice or oatmeal thick broth, symptomatic and supportive therapy.

Routes of administration

Inside, conjunctivally.

Precautions for the substance Potassium iodide

Before starting treatment, it is necessary to exclude malignant lesions of the thyroid gland. Use with caution in patients with impaired renal function (periodic monitoring of potassium levels in the blood is necessary).

Interactions with other active ingredients

Trade names

Name	The value of the Vyshkowski Index ®

Potassium iodide is a drug containing inorganic iodine, has antithyroid properties, replenishes iodine deficiency, and exhibits antiseptic and mucolytic activity.

Release form and composition

The product is available in the form:

• Potassium iodide film-coated tablets, dosage of 40, 125, 100, 200 mcg, in glass jars or contour packages;
• Potassium iodide solution 3% in 200 ml bottles;
• Eye drops Potassium iodide 3% in bottles of 5 or 10 ml.

The active substance in all forms of the drug is potassium iodide.

pharmachologic effect

When the medication enters the body, it compensates for the lack of iodine in the thyroid gland, entering the epithelial cells of its follicle and being exposed to thyroid peroxidase, it is oxidized, forming elemental iodine, which is included in tyrosine molecules. Thus, the drug promotes the synthesis of thyroid hormones - thyroxine and triiodothyronine. The use of potassium iodide in a dose of more than 6 mg per day, according to the feedback principle, in hyperthyroidism leads to inhibition of the synthesis of thyroid-stimulating hormone of the pituitary gland, reducing the susceptibility of the thyroid gland to it and preventing the production and release of thyroid hormones. The drug also helps reduce vascularization and size of the thyroid gland, thickens its tissue, and blocks its hyperplasia, including in children and adolescents. Iodide has a radioprotective effect due to its ability to prevent the uptake of radioactive iodine by the thyroid gland, thereby making it possible to effectively protect it from radiation. The medication is also used as a proteolytic, antifungal, expectorant and absorbent agent. When taken orally, potassium iodide has almost 100% bioavailability; absorption occurs completely in the small intestine.

Indications for use

According to the instructions, Potassium iodide is indicated for use for:

• Hyperthyroidism, thyrotoxic crisis;
• Treatment and prevention of endemic goiter;
• Protection from radiation and the need to prevent the thyroid gland from absorbing radioactive iodine isotopes;
• Actinomycosis of the lungs, bronchial asthma (with difficult sputum discharge);
• Prevention of goiter relapses (with complex treatment);
• Syphilis, in the tertiary period (in complex therapy);
• Cutaneous-lymphatic sporotrichosis;
• Erythema nodosum;
• Inflammatory diseases of the salivary glands, xerostomia.

Potassium iodide eye drops are used for fungal infections of the conjunctiva, eyelids and cornea as part of complex therapy, cataracts, clouding of the lens and vitreous body, hemorrhages in the eye membranes.

Directions for use and dosage

According to the attached instructions for Potassium iodide, tablets and solution are taken after meals with water, juice, tea or other liquid in sufficient quantities. To prevent goiter, children under 12 years of age take the drug at a dose of 50-100 mcg/day, adults and children over 12 years of age - 100-200 mcg/day, long-term, sometimes throughout life. Due to the threat of absorption of radioactive iodine, as a radioprotective agent, children over 2 years of age and adults are prescribed iodide 0.125 g per day, children under 2 years - 0.04 g per day (the tablet is allowed to be crushed) until the radioactive danger disappears. In complex therapy for hyperthyroidism before surgery - 250 mg three times a day for 10 days. When treating goiter, the drug is taken at a dose of 200-600 mcg/day for adults, 50-200 mcg/day for children and adolescents, treatment lasts from six months to a year or more. To prevent relapse of the disease, 100-200 mcg/day is prescribed.

A solution of Potassium iodide is used to thin sputum, taking two or three tablespoons (0.3-1 g) orally 3-4 times a day. For complex treatment of syphilis (in the tertiary period), the solution is used one tablespoon three times a day. Eye drops are prescribed 3-4 times a day, 1-2 drops, therapy lasts about two weeks.

Contraindications

According to the instructions for the drug, iodide is contraindicated for use when:

• Hyperthyroidism, in expressed and latent form (if doses exceed 150 mcg/day), nodular and diffuse toxic goiter (at doses of 300-1000 mcg);
• Toxic adenoma and benign tumors of the thyroid gland;
• Hypersensitivity to iodine;
• Pregnancy (the exception is the threat of penetration of radioactive iodine);
• Dermatitis herpetiformis (Dühring's disease);
• Lactation period;
• Pulmonary tuberculosis.

Potassium iodide is prescribed with extreme caution for nephrosis, nephritis, hemorrhagic diathesis, furunculosis, pyoderma and acne.

Side effects of Potassium iodide

Adverse reactions to the use of Potassium iodide can occur in rare cases - diarrhea, gastralgia, nausea, vomiting, headache, causeless irritability, urticaria, hemorrhage on the mucous membranes and skin. With long-term treatment, manifestations of iodism are possible in the form of: metallic taste, burning sensation in the mouth and throat, toothache, hyperemia, rhinitis, conjunctivitis, increased salivation, sore gums, dermatitis, swelling of the eyelids, bronchitis, arthralgia, acne, iodine fever. When using high doses of the drug, the development of hyperthyroidism, hypothyroidism, and thyrotoxicosis can sometimes be observed.

Interaction

The combined use of potassium iodide with lisinopril, captopril and enalapril increases the risk of hyperkalemia, and with drugs containing lithium in high doses - to the possible development of hypothyroidism and goiter. Concomitant use with potassium-sparing diuretics can cause arrhythmia and hyperkalemia.

Potassium iodide solution is a product that has an antiseptic effect. It is used to treat various diseases and anomalies associated with the visual organ. The medicine has an antimicrobial effect and has a good effect on affected tissues.

It also has an anti-sclerotic property, which helps speed up the process of resorption of hemophthalmos and infiltrates of keratitis of a syphilitic nature.

A solution of potassium iodide is called a complex remedy. Its action is based on the following processes.

• Acceleration of protein and lipid breakdown.
• An increase in the amount of lipoprotein in the blood.
• A decrease in blood viscosity, resulting in a slowdown in the development of atherosclerosis.
• Expansion of vascular walls.

The medicine will not help completely get rid of cataracts, but the salts contained in iodine can reduce the symptoms and also prevent a decrease in visual acuity.

After using the drug from the conjunctival sac, the liquid passes through the eye tissue and enters the nasal area, where the mucous membranes completely absorb the drug until the highest concentration is reached. It is worth considering the fact that iodine is not immediately excreted from the body. Therefore, if the patient is taking other iodine-containing drugs, they should be discontinued.

Composition of potassium iodide eye drops

Potassium iodide eye drops involve a two or three percent solution of potassium iodide, which is instilled into the conjunctival area. One milliliter of the product contains twenty milligrams or thirty milligrams of the active substance (depending on the percentage). The medicine also contains the following components:

• chlorhexidine diacetate;
• sodium chloride;
• sodium thiosulfate;
• the water is sterile.

Drops are produced in small bottles with a dispenser cap. Its volume is ten milliliters.

Scope of application of potassium iodide drops

Potassium iodide solution is used not only in ophthalmology, but also in other areas of medicine as a treatment for the following diseases.

1. Goiter in children and adults.
2. Hyperthyroidism.
3. Poor sputum discharge in inflammatory diseases of the respiratory tract.
4. Preventing the absorption of iodine by the thyroid gland under radiation conditions.
5. Syphilis.
6. Inflammation of the salivary glands and xerostomia.
7. Cataracts of various types.
8. Diseases of a fungal nature, the localization of which is located on the cornea or conjunctiva of the eye.
9. Hemorrhages of the ocular membrane.
10. Clouding of the vitreous.
11. Preventive measures to boost the immune system and treat the spinal column using electrophoresis.

Contraindications for the use of potassium iodide eye drops

Treatment with the drug is not suitable for all patients. Therefore, you cannot take it yourself without a doctor’s prescription and additional examination, which is carried out to diagnose the disease.

The main contraindications are:

• nephrosis;
• nephritis;
• manifestation of purulent boils;
• acne, acne;
• tumor-like neoplasms of a benign nature;
• enlarged goiter;
• thyroid adenoma, which is toxic;
• diathesis of hemorrhagic nature;
• high sensitivity to iodine.

Using potassium iodide solution

Before using the medicine, you should wash your hands thoroughly using soap-containing products. The procedure is necessary to ensure that no harmful bacteria and viruses remain on the bottle, because they can cause additional infection.

The dosage is selected strictly by the treating doctor, taking into account the disease and the cause that led to it. The standard instructions for use look like this: drop one or two drops of the solution into the conjunctival sac. The manipulations are repeated two to four times a day at regular intervals. It is worth noting that if suddenly, due to certain circumstances, it was not possible to drop the drug on time, then the procedure should be carried out as early as possible. It is not recommended to use double the dosage for subsequent use. The treatment course lasts from ten to fifteen days.

Occurrence of side effects

It is believed that this remedy is well tolerated by children and adults, but in some cases an allergic reaction may occur. This often happens due to non-compliance with doctor’s recommendations, exceeding the dosage, or prescribing the drug independently. Adverse reactions include the following.

• Tearing.
• Redness and irritability of the eyes.
• Swelling of the eyelids.
• Swelling of the lacrimal glands.
• Edema of the antioneurotic type (occurs extremely rarely).

If at least one of the above signs appears, it means that you should immediately stop using the drug and seek help from a doctor. Some patients experience burning or tingling sensations after instillation. Such symptoms do not require any treatment and are not signs when you need to stop taking the medication.

Taking potassium iodide solution during pregnancy

The product can be used during pregnancy only if it has been prescribed by a doctor and there is a need for it. The use of eye drops requires constant monitoring of the health status of the expectant mother. If adverse reactions were detected during pregnancy, it must be discontinued.

Storage of the drug

The closed bottle with drops should be stored in a dark place at room temperature. It is worth making sure that the place will be inaccessible to small children. After opening, eye drops are recommended to be stored for about thirty days. After the expiration date, throw away the bottle.

Overdose of solution

• nasal congestion;
• enteritis;
• bronchitis;
• the oral cavity becomes brown;
• anuria;
• the appearance of hoarseness in the voice.

If unwanted symptoms occur, you should immediately seek help from a doctor. If the symptoms are severe enough, then you need to call an ambulance. Several measures should be taken to treat an overdose.

1. Gastric lavage with sodium thiosulfate.
2. Consumption of porridge made from flour with a viscous consistency.
3. Taking a decoction of rice or oatmeal.
4. Carrying out appropriate treatment.

Analogs of potassium iodide eye drops

If side effects occur, the doctor may prescribe other medications that have similar properties and principles of action. These include:

• Phloxal.
• Albucid.
• Tobradex.

Potassium iodide solution is considered an affordable and effective treatment. If you follow all recommendations and precautions, no side effects will occur.

Pharmacodynamics

Iodine is an essential trace element necessary for the normal functioning of the thyroid gland. When iodides enter the epithelial cells of the thyroid follicle, iodine ions under the influence of the enzyme iodide peroxidase are oxidized to form elemental iodine, which is included in the tyrosine molecule. In this case, one part of the tyrosine radicals in thyroglobulin is iodinated, resulting in the formation of thyronines, the main of which are thyroxine (T4) and (T3). Thyronines form a complex with the protein thyroglobulin, which is deposited in the colloid of the thyroid follicle. Iodine entering the body in physiological quantities prevents the development of endemic goiter (associated with a lack of iodine in food); normalizes the size of the thyroid gland in newborns, children and adolescents; and also affects the T3/T4 ratio, the concentration of thyroid-stimulating hormone.

Pharmacokinetics

When taken orally, it is quickly and completely absorbed in the small intestine and distributed in the intracellular space within 2 hours.

It accumulates mainly in the thyroid gland (iodide concentration more than 0.5 mg/g tissue), as well as in the salivary and mammary glands, and the gastric mucosa.

Penetrates well through the placenta.

It is excreted mainly by the kidneys (trace amounts are determined in the urine 10 minutes after administration. 80% of the dose is excreted within 48 hours, the rest within 10-20 days), partially with the secretions of the salivary, bronchial, sweat and other glands.

2. indications for use

• prevention of the development of endemic goiter, including during pregnancy;
• prevention of goiter recurrence after completion of a course of goiter treatment with thyroid hormone preparations or after its surgical removal;
• treatment of diffuse euthyroid goiter in newborns, children, adolescents and young adult patients.

3. Method of application

The daily dose of the drug should be taken orally in one dose, after meals, with plenty of liquid.

When using the drug in newborns and children under 3 years of age, it is recommended to dissolve the tablet in a small amount (1 tablespoon) of boiled water at room temperature.

Prevention of the development of endemic goiter: newborns and children: 0.1 mg/day;

adolescents and adults: 0.1-0.2 mg/day;

during pregnancy and breastfeeding: 0.15-0.2 mg/day;

Prevention of goiter relapse after completing a course of goiter treatment with thyroid hormones or after its surgical removal: 0.1-0.2 mg/day.

Treatment of euthyroid goiter: newborns, children and adolescents: 0.1-0.2 mg/day; young adult patients: 0.3-0.5 mg/day.

The drug is taken for prophylactic purposes for, as a rule, several months or years, or, if indicated, for life.

Treatment of goiter in newborns is carried out in most cases within 2-4 weeks; in children, adolescents and adults it usually takes 6-12 months, long-term use is possible. The duration of treatment is determined by the attending physician.

4. Side effects

When using Potassium iodide according to indications in recommended doses, the occurrence of side effects is unlikely.

Allergic reactions may occur: rarely - skin rash.

5. Contraindications

• hypersensitivity to iodine;
• severe thyrotoxicosis;
• latent thyrotoxicosis (when using doses exceeding 0.15 mg/day);
• dermatitis herpetiformis;
• toxic adenoma, nodular goiter when used in doses of more than 0.3 mg/day (with the exception of preoperative therapy to block the thyroid gland);
• hereditary diseases associated with galactose intolerance, lactase deficiency or glucose-galactose malabsorption.

Potassium Iodide should not be taken for iodine, except in cases where the development of the latter is caused by severe iodine deficiency. The use of the drug should be avoided during therapy with radioactive iodine, the presence or suspicion of thyroid cancer.

6. During pregnancy and lactation

During pregnancy and breastfeeding, the need for iodine increases. Potassium iodide is prescribed according to indications in cases where the intake of iodine from food is less than 0.15-0.3 mg/day. The drug penetrates the placenta well and can cause the development of goiter in the fetus. Iodine is also excreted in breast milk. Therefore, during pregnancy and breastfeeding, potassium iodide should be used only in recommended doses.

7. Interaction with other drugs

Simultaneous use of antithyroid drugs weakens the effect of potassium iodide (mutually).

Potassium perchlorate and thiocyanate inhibit iodine uptake by the thyroid gland. Thyroid-stimulating hormone improves the absorption of iodine by the thyroid gland and stimulates the production of its hormones.

Concomitant use of angiotensin-converting enzyme inhibitors (including captopril, enalapril, lisinopril) increases the risk of hyperkalemia. High doses of iodine in combination with potassium-sparing diuretics can lead to hyperkalemia.

Simultaneous administration of iodine therapy in high doses and lithium preparations promotes the development of goiter and.

Reduces the uptake of 131I and 123I by the thyroid gland.

8. Overdose

When using Potassium iodide in a dose exceeding 0.15 mg/day, latent may become manifest.

With long-term use of potassium iodide at a dose exceeding 0.3 mg/day. iodine-induced development is possible (especially in elderly patients, in the presence of nodular goiter or toxic adenoma).

Symptoms of acute overdose: brown discoloration of mucous membranes, reflex vomiting, abdominal pain and (possibly melena). In severe cases, dehydration and shock may develop.

Treatment for acute overdose: gastric lavage, administration of sodium thiosulfate, symptomatic treatment of water-electrolyte imbalance, anti-shock therapy.

Chronic overdose can lead to the development of the phenomenon of “iodism”: “metallic” taste in the mouth, swelling and inflammation of the mucous membranes (gastroenteritis, bronchitis), acne, dermatitis, swelling of the salivary glands, fever, irritability.

Treatment for chronic overdose: drug withdrawal.

9. Release form

Tablets 40, 100, 125, 200 mg - 10, 20, 30, 40, 50 pieces and more.

10. Storage conditions

In a place protected from light at a temperature not exceeding 25°C.
Keep out of the reach of children.

Best before date

3 years.

11. Composition

Composition per 1 tablet 0.1 mg

- potassium iodide - 0.131 mg, in terms of iodine - 0.100 mg.
Excipients: lactose monohydrate (milk sugar) - 83.169 mg, microcrystalline cellulose - 12,000 mg, sodium carboxymethyl starch - 2,000 mg, corn starch - 1,200 mg, colloidal silicon dioxide - 0.500 mg, magnesium stearate - 1,000 mg.

Composition per 1 tablet 0.2 mg

potassium iodide - 0.262 mg, in terms of iodine - 0.200 mg.
Excipients: lactose monohydrate (milk sugar) - 83.038 mg, microcrystalline cellulose - 12,000 mg, sodium carboxymethyl starch - 2,000 mg, corn starch - 1,200 mg. colloidal silicon dioxide - 0.500 mg, magnesium stearate - 1,000 mg.

12. Conditions for dispensing from pharmacies

The drug is available without a prescription.

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* Instructions for medical use of the drug Potassium iodide are published in free translation. THERE ARE CONTRAINDICATIONS. BEFORE USE, YOU MUST CONSULT WITH A SPECIALIST