Candide gel instructions for use. Candide (vaginal gel) instructions for use, contraindications, side effects, reviews. Description of the dosage form

Name:

Candid

Pharmacological
action:

Antifungal drug, having a wide spectrum of action.
Active ingredient: Candida clotrimazole– is an imidazole derivative. Its antifungal effect is due to disruption of the production of ergosterol, which is part of the fungal cell membrane. As a result of the action of clotrimazole, the permeability of the cell membrane changes, which leads to cell lysis. Small doses of the drug have a fungistatic effect, large doses have a fungicidal effect, including on non-proliferating cells. Fungicidal concentrations of clotrimazole are able to interact with peroxidase and mitochondrial enzymes, contributing to an increase in the concentration (up to a toxic level) of hydrogen peroxide, which, in turn, also leads to the death of fungal cells.

Candide active against mold and yeast-like fungi(Rhodoturola, Torulopsis, Candida) and dermatophytes(Microsporum, Epidermophyton, Trichophyton), the causative agent of erythrasma, lichen versicolor, as well as Aspergillus, Malassezia furfur, gram-positive bacteria (Staphylococcus spp., Corynebacterium minutissimum, Streptococcus spp.) and gram-negative (Gardnerella vaginalis, Bacteroides spp.), and Trichomonas vaginalis.
Absorption of clotrimazole when administered intravaginally ranges from 3 to 10% of the administered dose. For 48-72 hours, low concentrations of the drug in the blood and high concentrations in the vaginal secretion remain. Clotrimazole is metabolized in the liver to inactive metabolites.

Indications for
application:

Candide used in therapy:

Mycosis of nails;
- multi-colored lichen;
- dermatophytosis of the head, legs, body;
- skin candidiasis;
- candidiasis vulvitis;
- candidal paronychia;
- candidal balanitis;
- candidiasis of the anus and external genitalia;
- erythrasma;
- fungal diaper dermatitis.

Used in the treatment of genital infections caused by Candida or Trichomonas vaginalis fungi, and genital superinfections caused by microorganisms sensitive to clotrimazole.
Candida is prescribed for the sanitation of the birth canal in preparation for childbirth.

Mode of application:

A small amount of lotion, gel or cream rub into a dry and clean area affected skin 2-3 times a day. It is recommended to continue therapy with Candida after the symptoms of the disease disappear for another 3-4 weeks to prevent relapses and complete mycological cure.
Candida in the form of lotion (solution) Recommended for use in cases of extensive lesions of the skin and scalp.
Candida in the form of vaginal tablets is inserted deeply, intravaginally, in a lying position, with legs bent. Candide is prescribed once before bedtime, 500 mg.
When using Candida to sanitize the birth canal, it is enough to administer 500 mg of the drug (1 tablet) once.

special instructions

To prevent urogenital reinfection, simultaneous treatment of sexual partners is necessary.

For trichomoniasis, for more successful treatment, other drugs that have a systemic effect (for example, metronidazole orally) should be used together with Candida.

In case of simultaneous infection of the labia and adjacent areas (candidal vulvitis), additional local treatment with Candida cream should be carried out.

During pregnancy, treatment with vaginal tablets should be carried out without an applicator.

In patients with liver failure, the functional state of the liver should be periodically monitored.

If signs of hypersensitivity or irritation appear, treatment is stopped.

If there is no effect within 4 weeks, the diagnosis should be confirmed.

Side effects:

For external use Candida in rare cases causes local irritation, which disappears on its own with continued treatment.

For intravaginal use Candida may cause burning, itching, vaginal discharge, swelling of the vaginal mucosa, headache, frequent urination, gastralgia, intercurrent cystitis, pain during sexual intercourse, burning in the partner’s penis.

Contraindications:

– specific skin lesions (including tuberculosis, chicken pox, herpes simplex, measles, syphilis);
– skin reactions at the vaccination site;
– hypersensitivity to the components of the drug.
– I trimester of pregnancy;
– period of menstruation.

Carefully:
– period of breastfeeding.

Interaction
other medicinal
by other means:

For vaginal insertion clotrimazole reduces the activity of Amphotericin B and other polyene antibiotics. With simultaneous use with nystatin the activity of clotrimazole may be reduced.

Pregnancy:

In clinical and experimental studies was not installed that the use of the drug during pregnancy or breastfeeding has a negative effect on the health of the woman or fetus (child). However, the question of the advisability of prescribing the drug should be decided individually after consulting a doctor.

Overdose:

The use of the drug in high doses does not cause any reactions or life-threatening conditions.

Symptoms(in case of unintended oral use of the drug): anorexia, nausea, vomiting, gastralgia, liver dysfunction; rarely - drowsiness, hallucinations, pollakiuria, allergic skin reactions.

Treatment: administration of activated carbon, if necessary - symptomatic therapy; There is no specific antidote. In aluminum tubes of 20 g; in a cardboard pack 1 tube.

Candide Solution for external applications 1%:

in plastic bottles of 20 ml, in a cardboard pack 1 bottle.

Candide Powder for external use application 1% white, with a characteristic odor.
1 g of powder contains clotrimazole 10 mg;
in plastic bottles of 30 g, in a cardboard pack 1 bottle.

Candide Solution for topical application 1% colorless, transparent, viscous.
1 ml of solution contains clotrimazole 10 mg;
excipients: propylene glycol - 495 mg; glycerin - 495 mg;
in dropper bottles of 15 ml, 1 bottle in a cardboard pack

Candide - vaginal tablets based on clotrimazole in a dosage of 500 mg. Can be prescribed to treat vaginal infections caused by yeast-like fungi, as well as trichomoniasis. Contraindications differ from Zalain. Before starting treatment, be sure to consult a specialist.

The analogue is more expensive from 151 rubles.

Synthesis (Russia) Clomegel is also available in the form of a vaginal gel for topical use, but differs from Ginofort in composition. Clomegel uses 2 active ingredients: clotrimazole and metronidazole. The list of indications for use is wider here.

The analogue is more expensive from 282 rubles.

The analogue is more expensive from 370 rubles.

Lomexin is an antiseptic and antimicrobial drug for topical use, which is available in the form of a vaginal cream. The active ingredient is fenticonazole nitrate 2%. The main indications for use: vulvovaginal candidiasis and vaginal trichomoniasis.

The analogue is more expensive from 152 rubles.

Candide is a topical antifungal cream based on clotrimazole (1%). Produced by the Indian company Glenmark. Sold in 20 ml tubes. Candide can be prescribed for the treatment of dermatophytosis capitis, mycosis of the skin, pityriasis versicolor, skin candidiasis, erythrasma and other diseases caused by fungal spores. The cream is contraindicated for specific skin lesions, hypersensitivity to components the drug and also during pregnancy and lactation.

Analogue is cheaper from 14 rubles.

Manufacturer: Hyperion SA (Romania), GlaxoSmithKline (UK)
Release forms:

• Cream 1%, 20 g (Hyperion SA); Price from 68 rubles

Prices for Clotrimazole in online pharmacies
Instructions for use

Clotrimazole is an antifungal and antibacterial agent that comes in the form of a cream. Intended for the treatment of ringworm, lichen versicolor, erythrasma and vulvovaginitis. The main active ingredient is clotrimazole (10 mg per 1 gram of cream). The drug is intended for external use. The dosage depends on the disease and the characteristics of the patient’s body.

Analogue is more expensive from 66 rubles.

Manufacturer: Agio Pharmaceuticals Ltd (India)
Release forms:

• Cream 2%, 15 g; Price from 148 rubles
• Cream 1%, 20 g (GlaxoSmithKline); Price from 129 rubles

Prices for Mykozon in online pharmacies
Instructions for use

Mikozon is an antifungal cream for topical use based on miconazole at 2% concentration. Prescribed for the treatment of dermatomycosis caused by fungi sensitive to the active substance. Use with caution for diabetes mellitus and microcirculation disorders.

Analogue is cheaper from 7 rubles.

Manufacturer: Ajio (India)
Release forms:

• Cream 1%, 20 g; Price from 75 rubles
• Cream 1%, 20 g (GlaxoSmithKline); Price from 129 rubles

Prices for Kanizon in online pharmacies
Instructions for use

Another Indian drug, which is significantly inferior in price to Candide B, although qualitatively it is its synonym with an identical list of indications. Contraindicated in case of hypersensitivity to the components of the drug and in the first trimester of pregnancy.

Analogue is cheaper from 29 rubles.

Manufacturer: Synthesis (Russia)
Release forms:

• Cream 1%, 30 g; Price from 53 rubles
• Cream 1%, 20 g (GlaxoSmithKline); Price from 129 rubles

Prices for Bifosin in online pharmacies
Instructions for use

Bifosin is also available in the form of a cream for the local treatment of fungal diseases, but differs from Clotrimazole in the active substance. Bifonazole is used here at a 1% dosage. Despite the differences in composition between Bifosin and Clotrimazole, they are very similar in indications.

The analogue is more expensive from 86 rubles.

Manufacturer: Bayer (Germany)
Release forms:

• Cream 1%, 20 g; Price from 168 rubles
• Cream 1%, 20 g (GlaxoSmithKline); Price from 129 rubles

Prices for Canesten in online pharmacies
Instructions for use

Canesten is a German antifungal drug for topical use. The active ingredient used here is clotrimazole in a 1% dosage. Indicated for the treatment of mycosis of the feet, hands, trunk, skin folds, pityriasis versicolor and erythrasma. Canesten is not prescribed during pregnancy and lactation.

The analogue is more expensive from 571 rubles.

Manufacturer: Gedeon Richter (Hungary)
Release forms:

• Cream vag. 5 years; Price from 653 rubles
• Cream 1%, 20 g (GlaxoSmithKline); Price from 129 rubles

Prices for Ginofort in online pharmacies
Instructions for use

A fairly expensive Hungarian drug from the pharmaceutical group of antiseptics and antimicrobials for the treatment of gynecological diseases. Indicated for use in cases of vaginal candidiasis caused by Candida albicans. Active ingredient: butoconazole nitrate 20 mg.

The analogue is more expensive from 389 rubles.

Manufacturer: Nizhpharm (Russia)
Release forms:

• Suppositories 400 mg. 5 pieces.; Price from 471 rubles
• Suppositories 400 mg. 10 pieces.; Price from 665 rubles

Prices for Livarol in online pharmacies
Instructions for use

Livarol is a vaginal suppository produced by the Russian company Nizhpharm. Intended for the treatment of acute and chronic mycosis of the vagina. Available in cardboard packages of 5 pieces, each suppository contains 400 mg. ketoconazole.

The analogue is more expensive from 347 rubles.

Manufacturer: Janssen-Cilag (Belgium)
Release forms:

• Suppositories 50 mg. 15 pcs.; Price from 547 rubles

Prices for Gino-pevaril in online pharmacies
Instructions for use

Glenmark (India) Candide - vaginal tablets based on clotrimazole in a dosage of 500 mg. It can be prescribed to treat vaginal infections caused by yeast-like fungi, as well as trichomoniasis. Contraindications differ from Zalain. Before starting treatment, be sure to consult a specialist.

The analogue is more expensive from 397 rubles.

Manufacturer: Egis (Hungary)
Release forms:

• Suppositories 300 mg. 1 PC.; Price from 479 rubles
• Suppositories 150 mg. 3 pcs.; Price from 429 rubles

Prices for Zalain in online pharmacies
Instructions for use

Zalain is a local antifungal agent intended for the treatment of infections of the vaginal mucosa caused by the activity of fungi of the genus Candida. The drug is available in the form of vaginal suppositories in packages of 1 piece or more. Sertaconazole nitrate is used as the active substance (300 mg per 1 vaginal suppository). Contraindications include hypersensitivity to sertaconazole, imidazole derivatives, benzotifene and other components of the drug. Before use, be sure to read the complete instructions for Zalain.

Candida is the trade name of clotrimazole, a popular remedy for infections of the skin and oral mucosa, as well as urogenital diseases of fungal pathogenesis. The manufacturer of the drug is the Indian pharmaceutical company Glenmark Pharmaceuticals. The instructions for use for Candide describe it as an antimycotic agent that helps against most dermatophytes, yeasts and molds, as well as some microbes and bacteria, including streptococci, staphylococci and other gram-positive pathogens.

Application

Clotrimazole is an active substance in the composition of the drug; it is an imidazole-based drug. Indications for use of Candida are identical to clotrimazole:

• candidal stomatitis – a fungal disease of the oral mucosa;
• urogenital trichomoniasis - a fungal infection caused by the bacterium Trichomonas;
• pityriasis versicolor and/or versicolor - a fungal infection of the skin on the torso and chest;
• foot fungus (so-called athlete's foot);
• fungal disease of fingernails and toenails;
• vaginal candidiasis (thrush);
• vaginitis, vulvitis (infection of the external female genitalia);
• fungal balanitis (disease of the skin of the head of the penis and foreskin);
• superficial mycoses of the skin;
• sanitation of female genital organs before childbirth.

Clotrimazole exhibits fungicidal activity - it inhibits the growth and reproduction of fungi by acting on the cell membrane of microorganisms. When used externally, it is poorly absorbed into the skin and mucous membranes.

Candida, depending on the form of the drug, is used for external or local application/introduction - applied to the skin or mucous membranes, and also inserted into the vagina to treat fungal diseases. Upon contact with the mucous membranes of the mouth, vagina and head of the penis, up to 10% of the active substance is absorbed.

Release forms

Candide is available in various forms intended for external and topical use:

All forms of the drug contain 10 mg of clotrimazole per 1 g of substance.

Instructions for use

Based on the form of the drug, it is applied to various parts of the body (skin around the nails, feet, skin folds, penis) or inserted into the vagina using an applicator or in the form of tablets.

For the oral cavity

For candidal stomatitis, a solution is used as a local drug, which is applied to the affected areas of the oral mucosa with a cotton swab 3-4 times a day. The course of therapy is up to 5 days or until the symptoms of fungal infection of the mucous membrane completely disappear.

For exposed skin

For the treatment of foot and nail fungus, cutaneous mycoses, color or pityriasis versicolor, manifested in the form of rashes, pigment spots, redness and itching in the folds of the skin, a gel/cream is taken. A small amount of the substance should be applied to the skin or mucous membranes 1-2 times a day after skin hygiene. The course of therapy is up to 3-4 weeks, plus another 14 days to consolidate the result.

For genitals

Candida can be used by both men and women to treat mycoses of the vulva, vagina, urethra and glans penis and foreskin. For infections of the vulva (external genitalia of women) and the head of the penis, a powder or gel is used, which is applied 2-3 times a day for 1-2 weeks.

For vaginal candidiasis (thrush), tablets are used that are inserted into the vagina. The treatment regimen, according to the annotation, is 500 mg once, 200 mg every day for 3 days or 100 mg for 7 days. The gel is inserted deep into the vagina in a supine position using a vaginal applicator, which is included in the package with the drug. It is better to administer the drug intravaginally before bedtime after genital hygiene.

The medicine must be stored in its original packaging, closed, in a dry place protected from direct sunlight at a temperature not exceeding 25 degrees.

Contraindications

The drug is not recommended for hypersensitivity to the active substance. During pregnancy, it is allowed to apply Candide to treat infections only on open areas of the skin - feet or hands. The medicine in the form of tablets or gel is not recommended for use in the 1st trimester, since there is no data on the effect of the active substance on the developing fetus. In the 2-3 trimester, intravaginal use in the form of tablets is conditionally permitted with the recommendation of a doctor. It is not advisable to use a special applicator with a plunger for insertion.

The drug is not used during menstruation. When using a cream, gel or powder to treat candidal balanitis or vulvitis, it is recommended to abstain from sexual intercourse. There is evidence that clotrimazole-based ointments and gels affect latex and may reduce the effectiveness of barrier contraceptives.

When treating genital infections in men and women, it is recommended that both partners be treated with the drug to avoid re-infection.

Side effects

Side effects noted by the manufacturer for topical or topical use of Candida include:

• when used externally - a burning sensation, itching, redness, swelling or flaking of the skin;
• in the treatment of urogenital fungal pathologies - itching, burning, swelling of the mucous membrane of the external genitalia, discharge from the genital tract, increased urge to urinate, pain during sexual intercourse;
• for the treatment of candidal stomatitis - redness, itching or irritation of the oral mucosa in the area of ​​application.

If the described side effects occur, it is recommended to stop using Candida and other clotrimazole-based drugs. Dermatologists advise choosing a drug based on another antimycotic component.

The cost of Candida, depending on the form of release, varies in the following values:

• vaginal tablets – 65-80 rubles;
• solution for external use – 330-370 rubles;
• liquid for topical use – 260-300 rubles;
• powder – 295-335 rubles;
• cream for external use – 230-285 rubles;
• vaginal gel – 100-120 rubles.

Candida has several analogues - preparations for external and local use based on clotrimazole:

• Candide-B6 (tablets).
• Clotrimazole (cream and ointment, tablets).
• Kanizon (cream, gel, tablets for insertion into the vagina, powder for external use).
• Kandizol (tablets for insertion into the vagina, cream for external use).

Clotrimazole is also included in such drugs as Canesten, Imidil, Amyclone, Faktodin, Candibene.

The drugs described above are synonyms or complete structural analogues, because have the same active ingredient. Cheap analogs of Candida that have similar pharmacological effects include drugs based on other antifungal drugs:

• ketoconazole (trade names Livarol, Dermazol, Mycozoral);
• miconazole (in the preparations Ginezol 7, Mikozon);
• naftifine (Exoderil, Mizol Evalar);
• terbinafine (Lamisil, Lamican, Fungoterbin);
• fluconazole (Diflucan, Flocoside, Flucostat).

These and other antifungal drugs are recommended for the treatment of skin fungal diseases of the nails, feet, urogenital fungal infections, stomatitis and other focal lesions of the skin and mucous membranes. The drugs can be found in the form of external and local use (gels, creams, powders, solutions, sprays, shampoos).

Overdose

There is no evidence of overdose with clotrimazole for external or topical use. If accidentally ingested, symptoms such as nausea, vomiting, heartburn, loss of appetite, stomach pain, and liver dysfunction may occur. Treatment is symptomatic (taking sorbents, antacids, antiemetic drugs).

Most reviews of the drug Candide indicate its high effectiveness. You can find responses about a solution for topical use, as well as cream and gel.

The majority of patients who have taken Candid are equally positive about the affordable price of the drug.

Conclusion

Candide is a modern antifungal drug based on clotrimazole, produced in the form of a solution, tablets for insertion into the vagina, cream, gel and powder for external and local use. The medicine produces a good fungicidal effect, helping with pathologies such as foot and nail fungus, thrush, balanitis, skin mycoses, stomatitis and other lesions of the skin and mucous membranes of fungal origin.

The drug can be used without age restrictions. The exception is individual sensitivity to clotrimazole, as well as pregnancy.

Candida, ointment (cream)

• Kanesten;
• Kandibene;
• Clotrimazole;
• Triderm;
• Akriderm GK.
• other ointments against fungus

Average price online *: 350 rub.

Instructions for use

Cream 1% white homogeneous. 1 gram of ointment contains 10 mg of the active substance clotrimazole. Additional components of Candida are paraffin, petroleum jelly, propylrabene, emulsion wax, butylated hydroxytoluene, alcohol, methylparaben, sodium dihydrogen phosphate, water. The cream is contained in a tube of 20 g.

Note: A special Candide gel with an applicator is available against thrush, check with the pharmacy.

pharmachologic effect

Candide is a broad-spectrum antifungal drug. It destroys the synthesis of fungi, thereby disrupting their structure. The causative agent of erythrasma, pityriasis versicolor, as well as mold and yeast fungi are also sensitive to this drug. The ointment is actively used to treat thrush in men and women, dermatophytes and other gram-negative bacteria. Candide also has antiprotozoal and antibacterial effects.

Dosage and method of administration

The affected area should be washed thoroughly with soap and dried. The ointment should be applied in a thin layer and rubbed in thoroughly. The course of treatment largely depends on the degree of the disease, the location of changes and the effectiveness of therapy.

• Dermatomycosis of the feet - from 4 weeks;
• Microsporia of smooth skin - 2 weeks;
• Pityriasis versicolor - from 1 to 3 weeks;
• For fungal infections of the legs, the course of treatment should be continued for another 2 weeks after the signs of the disease disappear;
• For candidiasis

For types of thrush such as balanitis in men or candidal vulvitis in women, the cream is applied 2-3 times a day for 1-2 weeks.

Indications and contraindications

Indications for prescribing the drug are:

• Mycosis of nails, feet and folds;
• Vulvitis candidiasis;
• Skin candidiasis;
• Dermatophyta of legs, head, body;
• Candidal paronychia;
• Candidal balanitis;
• Infections with mold and yeast fungi;
• Damages by pathogens that are especially sensitive to clotrimazole;
• Pityriasis versicolor;
• Candidiasis of the genital organs;
• Erythrasma.

Contraindications to the use of the drug Candide are:

• Hypersensitivity to the main substance – clotrimazole or to any other components of the cream;
• Period of menstruation;
• First trimester of pregnancy.

Side effects of the drug:

• Hives;
• The occurrence of pain during sexual intercourse;
• Burning sensation in the genitals;
• Redness of the skin;
• The appearance of blisters;
• Peeling of the skin;
• Swelling;
• Allergic reaction to the components included in the ointment.

The use of Candida in high doses does not cause any conditions or reactions that would be life-threatening.

This cream does not have any effect on driving, where concentration and reaction speed are required.

Pregnancy and lactation

Numerous studies have shown that the use of this ointment does not have any negative impact on the health of a woman and her child, both during pregnancy and during breastfeeding. However, the drug can be prescribed in the 2nd and 3rd trimester only as prescribed by a doctor. When prescribing, the doctor looks at the woman’s tolerance to the drug. He should also look at the ratio of the benefits of the cream for the mother and the possible risk of complications for her fetus.

You should also not use this product in the first trimester.

special instructions

The shelf life of the drug is 4 years. It is not recommended to use the drug after the expiration date. It is recommended to store it in a place protected from light at a temperature not exceeding 25°C. It is necessary to store the cream out of the reach of children. You can buy Candide in pharmacies without a doctor's prescription.

Our baby's redness started suddenly. At first there were a few spots, a little later redness covered 50% of the body. My wife was shocked, because nothing helped us, neither powders nor special creams or ointments that should be applied under the diaper. The diaper rash looked completely unusual. It was not just smooth skin with redness, but small red dots. The dots increased in size and turned into spots, which turned into sores. They were very bright in color. However, this did not cause any pain to the baby, despite the ominous appearance. And then our doctor prescribed Candide to us.

We started using the cream (according to the instructions: 2 times a day) with each diaper change. I would like to note that the cream is quite greasy to the touch, but it is applied evenly and without difficulty. We noticed the first improvements already on the third day. However, as the doctor explained to us, the course must be continued for 4 weeks, even if all the symptoms of the disease disappear.

One tube lasted us for one month.

If your baby has diaper rash, immediately ask your doctor about using Candida ointment. It helps a lot. My wife and I were pleased.

Leave your feedback in the comments!

* - Average value among several sellers at the time of monitoring, is not a public offer

1 comment

I would like to express my positive review of the Candide cream. For a long time I could not cure nail fungus, this disease created many problems, but I could not cure it, so I was advised to use Candide cream, which I did and after the first week of using this cream. I saw the result. Finally, the fungus began to decrease, and now, after a month of use, the nails have acquired a healthy appearance and there is almost no trace of the fungus left, but I need to apply it for another month to consolidate the result. I am not happy limit.

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Release forms

Candida instructions

Candide (active substance - clotrimazole) is a broad-spectrum antimycotic drug for external and local use, which has antimicrobial, antiprotozoal, and trichomonacid effects. The antifungal effect of Candida is due to its ability to disrupt the synthesis of one of the main structural components of the fungal cell membrane - ergosterol, which fundamentally affects its permeability and ultimately causes cell lysis. In small concentrations it acts fungistatically (inhibits the growth and development of fungal cells), and in large concentrations it exhibits fungicidal (destroying) activity. In the latter case, the drug interacts with mitochondrial enzymes and peroxidases, which causes an increase in the concentration of hydrogen peroxide above the toxic threshold, which also contributes to the death of fungal cells. Candide exhibits antifungal activity against dermatomycetes Epidermophyton floccosum, Microsporum canis, Trichophyton rubrum, Trichophyton mentagrophytes, yeast-like fungi Candida spp., incl. Candida albicans, Torulopsis glabrata, genus Rhodotorula. Acts on Pityrosporum orbiculare, the causative agent of lichen versicolor. Effective against infectious lesions caused by gram-positive bacteria: Corynebacterium mlnutisslmum (causative agent of erythrasma), Staphylococcus spp., Streptococcus spp. Candide also reduces the “population” of gram-negative microorganisms - Bacteroides, Gardnerella vaginalis. In submaximal concentrations it is effective against Trichomonas vaginalis. Candide is poorly absorbed through the skin and mucous membranes, which, however, is a positive property of the drug, since it deprives it of a systemic component, thereby reducing the risk of side effects. When used externally, the highest concentration of the active substance is observed in the epidermis (higher than in the deeper layers - the dermis and subcutaneous tissue). When administered intravaginally, the degree of absorption of Candida is 4-10% of the dose used.

◊ Vaginal gel uniform, white.

Excipients: cetyl alcohol, propylene glycol, glycerol, benzyl alcohol, cetomacrogol emulsion wax, carbopol 940 (carbomer 940), sodium hydroxide, chlorocresol, purified water.

30 g - aluminum tubes (1) complete with applicator - cardboard packs.

A drug with a wide spectrum of antifungal action for topical use in gynecology. The mechanism of the antifungal action of clotrimazole (imidazole derivative) is associated with disruption of the synthesis of ergosterol, which is part of the cell membrane of fungi, which changes the permeability of the membrane and causes subsequent cell lysis. In low concentrations it has a fungistatic effect, and in high concentrations it has a fungicidal effect, and not only on proliferating cells. At fungicidal concentrations, it interacts with mitochondrial and peroxidase enzymes, resulting in an increase in the concentration of hydrogen peroxide to a toxic level, which also contributes to the destruction of fungal cells.

Active regarding dermatophytes, yeast-like and mold fungi, as well as the causative agent of multi-colored lichen (Pityriasis versicolor) and the causative agent of erythrasma. Has an antimicrobial effect against gram-positive(staphylococci, streptococci) and gram-negative bacteria(Bacteroides, Gardneretla vaginalis), as well as against Trichomonas vaginalis.

Genital superinfections caused by microorganisms sensitive to clotrimazole.

Hypersensitivity to clotrimazole or other components of the drug.

Carefully the drug is prescribed during lactation.

The drug is intended for intravaginal use only.

A full applicator with gel (about 5 g of the drug) is inserted into the vagina, lying on your back with slightly bent legs, every evening for 6 days. A repeated course of therapy is possible only as prescribed by a doctor.

From the reproductive system: itching, burning, hyperemia and swelling of the vaginal mucosa, vaginal discharge, burning sensation in the penis of the sexual partner, pain in the vagina during sexual intercourse.

From the urinary system: frequent urination, intercurrent cystitis.

The use of the drug in high doses does not cause any reactions or life-threatening conditions.

When administered vaginally, clotrimazole reduces the activity of amphotericin B and other polyene antibiotics.

When used simultaneously with natamycin and nystatin, the activity of clotrimazole may be reduced.

To prevent urogenital reinfection, it is necessary to simultaneously treat sexual partners.

For trichomoniasis, it is recommended to use systemic medications (for example, metronidazole orally) simultaneously with Candida.

In patients with liver failure, the functional state of the liver should be periodically monitored.

If signs of hypersensitivity or irritation appear, treatment is stopped.

Avoid contact of the drug with the mucous membrane of the eyes.

If there is no effect within 4 weeks, the diagnosis should be confirmed.

Clinical and experimental studies have not found that the use of the drug in the second and third trimester of pregnancy or during lactation (breastfeeding) has a negative effect on the health of the woman or fetus (child). However, the question of the advisability of prescribing the drug should be decided individually after consulting a doctor.

If it is necessary to use the drug during pregnancy, the gel should be administered without the use of an applicator.

The article was written based on materials from the sites: www.proanalogi.ru, medamo.ru, xn—-btbfgpcpblyt3f.xn--p1ai, protabletky.ru, health.mail.ru.

Antifungal agent of the group of imidazole derivatives for topical use.
Medicine: CANDIDE

Active substance of the drug: clotrimazole
ATX coding: G01AF02
KFG: Drug with antifungal action for topical use in gynecology
Reg. number: LSR-000061
Registration date: 05/10/07
Owner reg. credential: GLENMARK PHARMACEUTICALS Ltd. (India)

Release form of Candide (vaginal gel), drug packaging and composition.

Vaginal gel is homogeneous, white.
Vaginal gel
1 g
clotrimazole
20 mg

Excipients: cetyl alcohol, propylene glycol, glycerol, benzyl alcohol, cetomacrogol emulsion wax, carbopol 940 (carbomer 940), sodium hydroxide, chlorocresol, purified water.

30 g - aluminum tubes (1) complete with applicator - cardboard packs.

DESCRIPTION OF THE ACTIVE SUBSTANCE.
All information provided is provided for information about the drug only; you should consult your doctor about the possibility of use.

Pharmacological action of Candide (vaginal gel)

Antifungal agent of the group of imidazole derivatives for topical use. It has an effect by disrupting the synthesis of ergosterol, which is an integral part of the cell membrane of fungi. Has a wide spectrum of action.

Active against dermatophytes, molds, fungi of the genus Candida, Malassezia furfur.

Clotrimazole is also active against Corynebacterium minutissimum, Streptococcus spp., Staphylococcus spp., Trichomonas vaginalis.

Pharmacokinetics of the drug.

When used externally, clotrimazole penetrates well into various layers of the skin, reaching therapeutic concentrations. When applied topically, a small amount of clotrimazole is absorbed into the blood.

Indications for use:

Fungal infections of the skin and mucous membranes caused by dermatophytes, mold and yeast-like fungi, lichen versicolor, erythrasma, vulvovaginal candidiasis, trichomoniasis, mycoses complicated by secondary pyoderma.

Dosage and method of administration of the drug.

For external use, apply to affected areas of the skin 2-3 times a day for 2-4 weeks.

When treating the oral cavity, use 1-2 times a day for no more than 7 days.

Intravaginally - 100-500 mg for 1-6 days.

Side effects of Candide (vaginal gel):

Local reactions: allergic contact dermatitis, redness, burning sensation.

Contraindications to the drug:

Hypersensitivity to clotrimazole, first trimester of pregnancy.

Use during pregnancy and lactation.

Experimental studies have shown that when used in high doses, clotrimazole has an embryotoxic effect.

It is not known whether clotrimazole is excreted in breast milk. Although clotrimazole is not contraindicated for use during pregnancy and lactation, the potential risk should be considered when choosing antifungal therapy.

Special instructions for use of Candide (vaginal gel).

Dosage forms intended for intravaginal use are not used during menstruation.

To prevent reinfection, simultaneous treatment of sexual partners is necessary. Clotrimazole is not recommended for use in ophthalmology.

Interaction of Candida (vaginal gel) with other drugs.

When used simultaneously with amphotericin B and nystatin, the activity of clotrimazole is reduced.

A drug with antifungal action for topical use in gynecology

Active substance

Release form, composition and packaging

◊ Vaginal gel uniform, white.

Excipients: cetyl alcohol, propylene glycol, glycerol, benzyl alcohol, cetomacrogol emulsion wax, carbopol 940 (carbomer 940), sodium hydroxide, chlorocresol, purified water.

30 g - aluminum tubes (1) complete with applicator - cardboard packs.

pharmachologic effect

A drug with a wide spectrum of antifungal action for topical use in gynecology. The mechanism of the antifungal action of clotrimazole (imidazole derivative) is associated with disruption of the synthesis of ergosterol, which is part of the cell membrane of fungi, which changes the permeability of the membrane and causes subsequent cell lysis. In low concentrations it has a fungistatic effect, and in high concentrations it has a fungicidal effect, and not only on proliferating cells. At fungicidal concentrations, it interacts with mitochondrial and peroxidase enzymes, resulting in an increase in concentration to a toxic level, which also contributes to the destruction of fungal cells.

Active regarding dermatophytes, yeast-like and mold fungi, as well as the causative agent of multi-colored lichen (Pityriasis versicolor) and the causative agent of erythrasma. Has an antimicrobial effect against gram-positive(staphylococci, streptococci) and gram-negative bacteria(Bacteroides, Gardneretla vaginalis), as well as against Trichomonas vaginalis.

Pharmacokinetics

When administered intravaginally, the absorption of clotrimazole is 3-10% of the administered dose. High concentrations in vaginal secretions and low concentrations in the blood persist for 48-72 hours. In the liver, clotrimazole is rapidly metabolized to inactive metabolites.

Indications

— vulvovaginal candidiasis;

- trichomoniasis;

- genital superinfections caused by microorganisms sensitive to clotrimazole.

Contraindications

- period of menstruation;

- hypersensitivity to clotrimazole or other components of the drug.

Carefully the drug is prescribed during lactation.

Dosage

The drug is intended for intravaginal use only.

A full applicator with gel (about 5 g of the drug) is inserted into the vagina, lying on your back with slightly bent legs, every evening for 6 days. A repeated course of therapy is possible only as prescribed by a doctor.

Side effects

From the reproductive system: itching, burning, hyperemia and swelling of the vaginal mucosa, vaginal discharge, burning sensation in the penis of the sexual partner, pain in the vagina during sexual intercourse.

From the urinary system: frequent urination, intercurrent cystitis.

Other:, gastralgia.

Overdose

The use of the drug in high doses does not cause any reactions or life-threatening conditions.

Drug interactions

When administered vaginally, clotrimazole reduces the activity of amphotericin B and other polyene antibiotics.

When used simultaneously with nystatin, the activity of clotrimazole may be reduced.

special instructions

To prevent urogenital reinfection, it is necessary to simultaneously treat sexual partners.

In patients with liver failure, the functional state of the liver should be periodically monitored.

If signs of hypersensitivity or irritation appear, treatment is stopped.

Avoid contact of the drug with the mucous membrane of the eyes.

If there is no effect within 4 weeks, the diagnosis should be confirmed.

Pregnancy and lactation

Clinical and experimental studies have not found that the use of the drug in the second and third trimester of pregnancy or during lactation (breastfeeding) has a negative effect on the health of the woman or fetus (child). However, the question of the advisability of prescribing the drug should be decided individually after consulting a doctor.

If it is necessary to use the drug during pregnancy, the gel should be administered without the use of an applicator.

For liver dysfunction

Conditions for dispensing from pharmacies

The drug is approved for use as a means of OTC.

Storage conditions and periods

The drug should be stored in a place protected from light, out of reach of children, at a temperature not exceeding 25°C; do not freeze. Shelf life - 3 years.