Instructions for medical use
medicine
A nicotinic acid
Tradename
A nicotinic acid
International nonproprietary name
A nicotinic acid
Dosage form
Solution for injection 1%, 1 ml
Compound
1 ml of solution contains
active substance - nicotinic acid 10 mg,
Excipients: sodium bicarbonate, water for injection.
Description
Transparent, colorless liquid.
Pharmacotherapeutic group
Lipid-lowering drugs. Hypocholesterolemic and hypotriglyceridemic drugs. Nicotinic acid and its derivatives . A nicotinic acid.
ATX code C10AD02
pharmachologic effect
Pharmacokinetics
Nicotinic acid is rapidly absorbed when administered parenterally. Evenly distributed throughout organs and tissues. Inactivated mainly by methylation and less by conjugation. Partially biotransformed in the liver with the formation of N-methylnicotinamide, methylpyridonecarboxamides, glucuronide and a complex with glycine. Half-life (T 1/2) - 45 minutes. It is excreted from the body by the kidneys in unchanged form and in the form of metabolites. Renal clearance depends on the concentration of nicotinic acid in the blood plasma and may decrease at high plasma concentrations.
Pharmacodynamics
The structure of nicotinic acid is close to nicotinamide.
Nicotinic acid and its amide play a significant role in the life of the body: they are prosthetic groups of enzymes - codehydrase I (diphosphopyridine nucleotide - NAD) and codehydrase II (triphosphopyridine nucleotide - NADP), which are hydrogen carriers and carry out redox processes. Codehydrase II is also involved in phosphate transport.
Nicotinic acid replenishes the deficiency of vitamin PP and has a vasodilating effect. Participates in the regulation of tissue respiration, fat metabolism, reduces total cholesterol and low-density lipoproteins (especially triglycerides).
Indications for use
As part of complex therapy: vascular spasm of the extremities (obliterating endarteritis, Raynaud's disease), neuritis of the facial nerve, ischemic cerebrovascular accidents
Directions for use and doses
Nicotinic acid is administered to adults subcutaneously, intramuscularly or slowly intravenously.
For intravenous jet administration a single dose of the drug is diluted in 10 ml of 0.9% sodium chloride solution, administered no less than 5 minutes (no faster than 2 mg of nicotinic acid in 1 minute).
For intravenous drip administration a single dose of the drug is diluted in 100-200 ml of 0.9% sodium chloride solution, the rate of administration is 30-40 drops per minute.
Subcutaneous and intramuscular injections are painful.
For pellagra, a 1% solution of 1 ml is administered intravenously or intramuscularly 1-2 times a day for 10-15 days.
In case of ischemic cerebrovascular accident, 1 ml of 1% solution is administered intravenously (slowly).
For other indications prescribed subcutaneously or intramuscularly at 10 mg (1 ml) 1 time per day for 10-15 days. It is possible to add to the infusion solution: 10 mg (1 ml) of nicotinic acid per 100-200 ml of infusion solution.
Higher doses for intravenous administration: single - 100 mg (10 ml), daily - 300 mg (30 ml).
Side effects
Hyperemia of the face and upper half of the body with a sensation
tingling and burning (in people with hypersensitivity)
Hives, skin rash, itching
Dizziness, feeling of a rush of blood to the head, headache
Orthostatic hypotension, collapse (with rapid intravenous administration)
With long-term use of large doses
- dry skin, exfoliative dermatitis
lactate dehydrogenase, alkaline phosphatase
- asthenia
- pain at the site of subcutaneous and intramuscular injections.
Contraindications
Hypersensitivity to nicotinic acid
Severe forms of arterial hypertension
Atherosclerosis (for intravenous injections)
Peptic ulcer of the stomach and duodenum (at the stage
exacerbation)
Severe liver dysfunction: hepatitis, liver cirrhosis
Recent myocardial infarction
Decompensated diabetes mellitus
Gout and hyperuricemia
Pregnancy, lactation period
Children under 18 years of age
Drug interactions
Oral contraceptives and isoniazid reduce the conversion of tryptophan to niacin and thus may increase the need for niacin.
Nicotinic acid reduces effectiveness and toxicity barbiturates, antituberculosis drugs, sulfonamides. When used together with sulfonylureas, it may increase blood glucose levels. Nicotinic acid also reduces the toxicity of neomycin and prevents the decrease in the concentration of cholesterol and high-density lipoproteins induced by it.
Antibiotics may increase skin redness caused by nicotinic acid.
Acetylsalicylic acid reduces the effect of skin redness that occurs under the influence of nicotinic acid.
Lovastatin, pravastatin Due to the increased risk of adverse reactions, it is not recommended to combine it with nicotinic acid.
Caution must be exercised when combined with antihypertensive drugs(possible increased hypotensive effect), anticoagulants, acetylsalicylic acid(due to the risk of developing hemorrhages).
The drug potentiates the effect fibrinolytic agents, antispasmodics and cardiac glycosides, toxic effects of alcohol on the liver.
Do not mix with thiamine chloride solution (thiamine is destroyed).
special instructions
Before using the drug, you should consult your doctor.
Since long-term use can lead to fatty liver disease, to prevent the latter, patients’ diets include foods rich in methionine or prescribe methionine and lipoic acid. During treatment it is necessary to monitor liver function. If hypersensitivity to the drug occurs (except when used as a vasodilator), it can be replaced with nicotinamide.
Carefully the drug is used for hyperacid gastritis, gastric and duodenal ulcers (outside the acute stage).
The use of the drug may lead to an increase in the need for insulin in patients with diabetes. It is not advisable to use for the correction of dyslipidemia in patients with diabetes mellitus.
It is necessary to regularly monitor glucose due to a possible decrease in glucose tolerance, as well as serum uric acid levels due to a possible increase as a result of long-term therapy.
Carefully prescribed for glaucoma, bleeding, arterial hypotension, impaired liver and kidney function, liver diseases and a history of impaired liver function, diabetes mellitus, heart rhythm disturbances, migraines, alcohol abuse.
Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous mechanisms
Considering the side effects of the drug, caution should be exercised when driving vehicles and moving machinery.
Symptoms: increased side effects from the cardiovascular system - arterial hypotension, headache, possible loss of consciousness, dizziness, feeling of a rush of blood to the head.
Treatment: drug withdrawal, detoxification therapy, symptomatic treatment. There is no specific antidote.
Release form and packaging
1 ml in neutral glass ampoules for syringe filling or imported, or sterile ampoules for syringe filling imported, with a break point or break ring.
A label made of label or writing paper is affixed to each ampoule.
5 or 10 ampoules are packed in blister packs made of polyvinyl chloride film and aluminum or imported foil.
Outline packages are placed in boxes made of cardboard or corrugated cardboard.
Approved instructions for medical use in the state and Russian languages are placed in group packaging with contour packaging. The number of instructions is calculated according to the number of boxes or packages.
Storage conditions
Store in a place protected from light, at a temperature not exceeding 30 o C.
Keep out of the reach of children!
Shelf life
Do not use after expiration date.
Conditions for dispensing from pharmacies
On prescription
Manufacturer
Registration Certificate Holder
JSC "Khimpharm", Republic of Kazakhstan
Address of the organization that accepts claims from consumers regarding the quality of products (products) on the territory of the Republic of Kazakhstan
JSC "Khimpharm", Republic of Kazakhstan
Shymkent, st. Rashidova, 81
Phone number 7252 (561342)
Fax number 7252 (561342)
E-mail address [email protected]
Nicotinic acid is a vasodilator and antipellagritic agent.
Active ingredient: nicotinic acid:
Nicotinic acid is also used as part of combination therapy for the following diseases:
Absolute:
Relative (the drug should be used with extreme caution due to the risk of complications):
Pills
The tablets should be taken orally after meals.
Injection
For pellagra, 1 ml is administered intramuscularly, intravenously or subcutaneously 2-3 times a day for a course of 10-15 days.
For ischemic stroke, nicotinic acid is administered slowly intravenously at a dose of 10 mg.
For other indications, 10 mg is usually prescribed 1-2 times a day for 10-15 days.
The maximum permissible single dose for adults is 100 mg, daily – 300 mg.
For Hartnup disease, the daily therapeutic dose can vary from 40 to 200 mg.
Liver function should be monitored during treatment. To prevent complications, include foods containing methionine (for example, cottage cheese) in your diet, or take lipoic acid, methionine and other lipotropic drugs.
Particular caution should be exercised in the case of simultaneous use of ascorbic acid, anticoagulants and antihypertensive drugs.
Nicotinic acid, injections, what they are prescribed for - this question often arises. The name may be a little misleading, but it is actually a very useful substance. It is actively used in medicine, because the so-called nicotine is a vitamin-like substance that has a beneficial effect on the body.
The drug has many positive properties and its health benefits are impressive. If the body contains nicotine in sufficient quantities, then all organs and systems in it function clearly and correctly. Nicotinic acid, injections, what are they prescribed for? It is used for different purposes - for example, for:
Among other things, nicotine improves sleep, stabilizes blood cholesterol levels, takes part in the production of gastric juice and controls some functions of the digestive tract. By understanding what nicotinic acid helps with, and for what purpose the injections are prescribed, you can understand why doctors chose injections. Everything is simple with this - this way the drug penetrates the body faster and is distributed more evenly. In addition, the injections help prevent irritation of the gastric mucosa.
The substance can be taken both for treatment and as a prophylactic. Nicotinic acid, injections, what are they prescribed for? One of the most common indications is a lack of vitamin PP - pellagra. The drug is effective for diseases of the cardiovascular system. It helps dissolve blood clots. Thanks to this, areas of blood vessels that were blocked open up.
Before you start using nicotinic acid, injections, the instructions for its use must be studied. From it you can find out that the medicine is also prescribed for:
This disease occurs when the cartilage in the spinal discs does not receive enough nutrition. As a result, structural changes begin to occur in them, and they become thinner. At the same time, the condition of the bone tissue deteriorates, which becomes deformed and becomes covered with growths in some places. Nicotinic acid, injections, what are they prescribed for, in this case - how can they help? Very fast and efficient!
The injections begin to work almost immediately.
This substance is often found in hair care products.
We have sorted out nicotinic acid, hair injections, and what they are prescribed, but you also need to know how to use the drug correctly. To make your hair healthier and stronger, use the product for a month. Every day, the contents of one ampoule are applied to clean curls. Treatment can be done by hand or using a syringe without a needle. If 1 ml is not enough, you can use a second ampoule at a time, but no more.
There is no need to wash off the nicotine mask. Immediately after the procedure, goose bumps, a burning sensation, and redness may appear. This phenomenon is normal - it means that the remedy has begun to work. Another thing is headache, itching and rash. Such symptoms indicate individual intolerance and that hair treatment with nicotinic acid should be stopped. Those for whom the therapy is suitable will notice a growth of up to 3 centimeters in their curls within a month.
Every body needs nicotinic acid. The optimal amount is up to 20 milligrams per day. You can get it from food - meat and some plant products. A deficiency of the substance has a negative effect on health. This leads to a lack of serotonin, and the body tries to compensate for the deficiencies of the latter by demanding high-calorie foods - cakes, buns, sweets.
How do nicotinic acid injections help you lose weight? Of course, she is not a fat burner. That is, just injections cannot cope with extra pounds, but they can:
Simply put, nicotine will discourage you from eating unhealthy, fatty, high-calorie foods, help you stick to a proper diet, and enhance your metabolism.
To get the most from the drug, it must be used correctly. The regimen of nicotinic acid injections must be strictly followed, and it should be selected by a specialist. The standard scheme may not suit everyone. During treatment, it is very important to take into account all the individual characteristics of the body. Otherwise, therapy will not help, or even harm and worsen the condition.
The doctor should calculate the dosage and number of necessary injections per day. He also makes the decision to increase or decrease the dose. According to the standard, nicotinic acid, an injection solution, is injected into the body at a rate of 0.1 grams 2 - 3 times a day. If the patient tolerates this treatment well, the dosage may increase to 5 grams. This amount of the drug is usually prescribed for atherosclerosis or serious problems with fat metabolism.
The drug nicotinic acid, injections, are given slowly. To ensure that no traces remain on the body after the procedure - irritation, rashes, wounds - doctors use substances such as Sodium Nicotinate or Nicotinamide. There are different methods of administering injections:
Bad news, but it's true. The answer to the question whether an injection of nicotinic acid is painful or not is positive. When administered subcutaneously and intramuscularly, the patient feels very severe pain and burning. After the procedure, the skin turns red, some people develop a fever, but this is an absolutely normal reaction of the body. It’s worse if the injection has no consequences. In this case, you can suspect the presence of problems with blood circulation.
Another advantage of nicotine is that it can prevent ethanol poisoning - if you take it 10 - 12 hours before drinking alcohol, but it is undesirable for the substances to be in the body at the same time. Strong drinks neutralize the effect of the medicine, and it turns out that nicotinic acid and intramuscular injections were used in vain. In addition, ethanols increase the risk of adverse reactions. The best option is to give injections a few hours after alcohol enters the body.
Before starting a course of injections, you need to consult with a specialist and find out whether there are any contraindications to the use of the drug. Intramuscular injections of nicotinic acid are contraindicated for:
Nicotinic acid has several medicinal properties. It dilates blood vessels, improves blood circulation, and regulates redox processes. Nicotinic acid is included in the mandatory treatment program for many pathologies, including acute and chronic osteochondrosis.
Nicotinic acid (synonyms: vitamin PP, vitamin B3, niacin) belongs to the group of drugs that affect tissue metabolic processes. This is a vitamin preparation, but in its pharmacological action it is not inferior to the action of medicinal drugs.
Nicotinic acid is found in its natural form in vegetables and fruits, fish, dairy products and cereals. For a healthy person, vitamin intake from foods is sufficient. But with illnesses, the need for it increases sharply.
Used for medicinal purposes, preparations with nicotinic acid dilate blood vessels, increase blood fluidity, stabilize blood cholesterol levels, and prevent blood clots.
Most often, nicotinic acid is prescribed for neurological diseases. This is one of the vitamin preparations with a healing effect. The introduction of vitamin PP has a beneficial effect on nerve cells.
All forms of drug release
Under the influence of nicotinic acid, the speed of transmission of nerve impulses changes, the process of regeneration of nerve tissue improves, and blood pressure levels return to normal.
Due to the dilation of blood vessels, blood flows into the pathological focus, which accelerates the healing and regeneration process.
Niacin is an activator of enzymatic processes, a component for the formation of sex hormones (estrogen, testosterone, progesterone).
Preparations based on nicotinic acid are included in the treatment program for removing toxic substances from the body.
Regular maintenance therapy with nicotinic acid is indicated for patients with chronic headaches and migraine attacks.
The drug is available in the form of tablets and 1% injection solution.
For a healthy person, the daily requirement of nicotinic acid is about 25 mg. In what cases is it necessary to increase the daily requirement:
Video on the topic:
In addition to being used for preventive purposes, the drug Niacin is used in the complex treatment of many diseases:
One of the side effects of using the drug is severe hyperemia of the skin. This is a temporary phenomenon and goes away on its own.
Uncontrolled, long-term treatment with niacin can provoke fatty liver hepatosis and disturbances in the gastrointestinal tract.
Very carefully, for special indications, nicotinic acid is prescribed to patients with severe damage to the kidneys, liver, and patients with persistent hypotension.
The drug Niacin is not prescribed to patients with ulcerative pathology of the mucous membrane during an aggravated period.
One of the causes of osteochondrosis is a deficiency of nutrients in the cartilage plates of the vertebral discs, and as a result, irreversible degenerative changes.
As the disease progresses, it thins and destroys not only the discs, but also the bone structures.
To stop this process, to increase blood flow to the vertebral structures and nearby tissues, nicotinic acid is indicated along with other vasodilating drugs.
The drug Niacin restores cerebral circulation, which is also impaired in osteochondrosis due to compression by bone and cartilaginous structures.
What effect can be obtained by using nicotinic acid for all forms of osteochondrosis?:
In order for drug treatment to give the desired therapeutic effect, three rules must be followed:
Single, periodic administrations of the drug will not provide a lasting therapeutic effect.
The doctor prescribes the Niacion treatment regimen. Correct dosages and a correctly prescribed course are important: an overdose of Niacin can lead to serious consequences for the patient’s health.
Intramuscular injections of the drug are painful. Therefore, in the acute stage, injections of nicotinic acid are prescribed in a dosage of 1 or 2 ml daily intravenously.
The drug should be administered as slowly as possible and the patient should be in a horizontal position. From the rapid entry of the drug into the bloodstream, severe dizziness, a feeling of heat, and hypertension are possible.
After treatment with injections, a tablet form of the drug is prescribed.
Dose adjustment and treatment regimen for taking Niacin for osteochondrosis are determined by the attending physician.
The drug nicotinic acid belongs to the vitamin derivatives of pharmacological production. This drug has a number of effects on the human body. This allows it to be used effectively for many diseases.
Among the positive effects of nicotinic acid on the human body, the following should be noted:
These are not all the positive properties of nicotinic acid; the instructions for use that we offer you will help you understand all the therapeutic effects. We hope to help you evaluate and use this drug.
The drug nicotinic acid has quite extensive indications for use. This drug can be taken both for medicinal purposes and for the prevention of many diseases.
In particular, nicotinic acid is used for medicinal purposes in the following diseases and conditions:
For prevention, nicotinic acid is used in:
The use of nicotinic acid requires careful monitoring by the attending physician. Self-treatment with nicotinic acid is not allowed due to the fact that negative consequences may develop in the human body. Like any other vitamin preparation, if overdosed, it causes irreparable damage to your health.
Very often, the vitamin nicotinic acid finds non-standard uses. In particular, this drug is very often used to rejuvenate and renew the skin of the face and body in many beauty salons. In fact, this is a completely justified method only if the treatment is carried out under the supervision of an experienced doctor.
Nicotinic acid has very different indications in this case. However, the principle of influence is quite simple.
This drug has a unique ability:
All together this has a rejuvenating effect on the human body. This is best seen on the skin. The skin becomes smooth, moisturized and receives a pleasant pink tint.
Injections of nicotinic acid help to quickly introduce the drug into the human body and ensure its uniform distribution. Nicotinic acid in injections helps to avoid such negative side effects as irritation to the gastric mucosa. Nicotinic acid in ampoules is prescribed for:
Nicotinic acid is available in ampoules of 1 ml of 1% solution. Usually prescribed 1 ampoule subcutaneously, intramuscularly or intravenously once or twice a day.
Nicotinic acid injections can be given in three ways:
Intramuscular and intradermal injections of nicotinic acid are quite painful. There is a burning sensation. After an intravenous injection of nicotinic acid, you may experience heat and redness of the skin. This is a normal physiological reaction of the body. If redness is not observed, this may indicate that the person has certain problems with blood circulation.
Nicotinic acid tablets can be used for prevention and long-term treatment of certain diseases. In particular, nicotinic acid tablets are recommended to be used twice a year, in spring and autumn, 1 month each, for people who suffer from problems with blood circulation in the lower extremities. Thrombophlebitis and venous insufficiency are a direct indication for the use of nicotinic acid in tablets over a long period of time.
The drug nicotinic acid in tablets is used depending on the person’s weight and the severity of the disease, 1-2 tablets 3 times a day. It is advisable at this time to introduce cottage cheese and other foods rich in methionine into your diet. This will help protect liver cells. In case of increased acidity of gastric juice, nicotinic acid tablets should be consumed after meals and washed down with plenty of mineral water or warm milk.
Vitamin nicotinic acid has minor contraindications. Generally, this drug is not recommended for use if:
Also, nicotinic acid may have contraindications in a number of individual cases. Only a doctor can determine the advisability of using nicotinic acid in one form or another.
Prescribing electrophoresis with nicotinic acid for osteochondrosis helps to quickly remove accumulations of lactic acid from tissues affected by the inflammatory process. This reduces swelling and eliminates pain. Also, electrophoresis with nicotinic acid can ensure faster delivery of other medications to the affected area. This becomes possible due to the fact that blood flow increases and tissues are better supplied with oxygen and nutrients. Accordingly, the healing process goes much faster.
Most often, electrophoresis with nicotinic acid is prescribed once a day for ten days.
To obtain the maximum effect, treatment with nicotinic acid should be started only after a complete examination of your health. The maximum effect is achieved only if a certain condition is associated with a lack of this vitamin in the human body.
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