Preductal - what are the Russian analogues? Preductal MV indications for use analogues

Preductal is a medicine that improves metabolic processes in cardiomyocytes, which helps to effectively combat ischemia.

The drug is prescribed for chronic heart failure, angina pectoris, and hypertension.

Available in 2 forms - Preductal OD and Preductal MV. The first contains 80 mg of trimetazidine, is characterized by a slow release of the component and a longer action. The frequency of administration of Preductal MB is more frequent due to the fact that the active substance content is 35 mg.

The drug is original, for this reason it has a high cost. Not every person can afford to purchase Preductal.

Therefore, a large number of pharmacological companies from different countries produce analogues (synonyms) of this drug. Russia is among these states. The drug Preductal and its analogues have different prices.

The mechanisms of action are similar, but the drugs are sold under different trade names.

Antisten

The Russian medicine Antisten is a cheaper analogue of Preductal. The main component is trimetazidine, which has a positive effect on cardiomyocytes and cells of the central nervous system. The active substance content is 20 mg, the instructions for use are simple, but despite this, a preliminary consultation with a doctor is required.

Antisten is prescribed for coronary heart disease and dizziness of vascular origin (as Preductal). A cheaper analogue drug is not recommended in the following cases:

1. Patients are under 18 years of age.
2. Pregnancy and lactation period.
3. Severe liver dysfunction.
4. Kidney failure.
5. The presence of hyperreactivity reactions in patients to the components of the drug.

Taking Antisten may cause adverse reactions (like Preductal). Most often, patients complain of dyspeptic symptoms - nausea, vomiting, unpleasant taste in the mouth, abdominal pain.

The general condition of the body often suffers - patients in such situations are diagnosed with weakness, headaches and dizziness.

Sometimes people taking the drug note the presence of hot flashes to the face, darkening of the eyes and loss of stability with a sudden change in body position.

Trimetazidine

This drug is sold in pharmacies under a name that matches the name of its active substance.

This analogue of Preductal is prescribed for coronary heart disease, either alone or as part of complex therapy for pathology.

The drug is also used for hearing impairment, which is caused by pathological processes in the blood vessels of the brain. The price of the medicine is cheaper than other analogues. Preductal itself is more expensive.

A cheap analogue is a drug that improves metabolic processes in the cells of the heart muscle and central nervous system.

It helps improve energy metabolism in the body and maintain the ionic composition of cells at an optimal level.

The drug is used in the treatment of ischemia and helps increase the body's tolerance to physical activity. The number and severity of attacks of shortness of breath with chest pain is significantly reduced.

The use of the drug is contraindicated during pregnancy and lactation, as well as in the presence of allergic reactions to the components of the drug.

The following adverse reactions are noted: nausea, vomiting, abdominal pain. Sometimes patients are concerned about the appearance of an itchy rash on the body. In general, the drug is well tolerated, even over long-term use.

Deprenorm

Another analogue. This drug is a Russian analogue of Preductal, and will cost less than Preductal or Antisten itself. The active ingredient is trimetazidine dihydrochloride, tablets can contain 35 and 70 mg of this component. Therefore, Preductal MV can easily be replaced with cheap Deprenorm.

The analog affects the cells of the heart and nervous tissue in such a way that energy substances accumulate in them, which allows patients to better tolerate physical activity (like Preductal). The drug also helps to improve the ion-cation composition of cells, thereby positively affecting structures damaged by ischemic processes.

A cheaper analogue of Preductal - Deprenorm - is better used to keep blood pressure and heart rate at an optimal level. The drug also improves the functional parameters of the left ventricle of the heart and retina.

This cheap analogue of the drug Preductal is prescribed for the same heart diseases as the previous drugs - coronary disease, heart failure. Used for headaches and dizziness. The main goal of application is to improve cellular metabolism and reduce the degree of negative impact of pathological processes on target organs.

List of contraindications:

1. Severe renal failure.
2. Serious liver dysfunction.
3. Parkinson's disease or parkinsonism syndrome (develops as a complication of other pathologies of the central nervous system).
4. Pregnancy and lactation.
5. In cases where the patient is under 18 years of age.
6. Presence of tremors or restless legs syndrome.
7. Hypersensitivity to the drug.

When using Deprenorm, the following adverse reactions may occur: headaches and tremors, difficulty falling asleep, instability when walking, general emotional depression. Patients often complain of diarrhea or constipation, abdominal pain, and nausea.

While taking the drug, the composition of the blood formula may change; some patients note a deterioration in their health with a sharp rise. Sometimes allergic reactions occur in the form of rash, itching, and in rare cases, Quincke's edema.

Prestarium

This drug does not belong to the group of analogues of Preductal; the active ingredient of Prestarium is perindopril, which lowers blood pressure.

In addition, the drug constricts arterial vessels, improves reparative processes, thereby restoring their elasticity. These mechanisms help normalize metabolism in cardiac muscle cells.

The effect is the same as that of Preductal. Therefore, the product can be considered as an incomplete analogue.

Prestarium reduces heart rate and left ventricular myocardial hypertrophy (like Preductal). For these reasons, many patients using the drug note an improvement in their well-being and it is easier for them to tolerate physical activity. A good effect depends on the patient’s heart and his general condition.

Prestarium is produced by a French company, the substance is part of the original production product. The preductal is equal in cost and is produced by the same company.

Indications for use:

1. Arterial hypertension.
2. Chronic heart failure.
3. Cardiac ischemia.
4. Used to prevent stroke and its complications.

The analogue drug is not used for stenosis of the renal arteries, impaired excretory function of the kidneys, renovascular hypertension, or disturbances in the water-salt balance of the body. Prestarium should not be used for galactosemia and malabsorption. The analogue has restrictions for children and adults with autoimmune pathologies.

Side effects include the presence of dyspeptic symptoms, deterioration of respiratory and excretory function, as well as the appearance of an itchy rash and erythema on the skin. The drug is able to change the blood formula and increase liver enzymes. In some cases, patients begin to experience deterioration in visual and auditory function, poor sleep, and seizures.

Trimectal

This cheap analogue of Preductal is produced by a Russian company and is sold at the same price as Deprenorm. The active substance is trimetazidine at a dosage of 20 mg.

A cheap analogue, like Preductal, improves metabolic processes in nerve cells and cardiomyocytes, providing a protective effect. The product helps improve the ion-cation composition of cellular structures, preventing the destruction of membranes. Also, an analogue of the drug Preductal helps restore those tissues that have been exposed to ischemic processes.

Prescribed for angina pectoris, visual and auditory disorders, dizziness. This cheap analogue is not recommended for use in case of renal and liver failure, allergies to the drug, persons under 18 years of age, and pregnant and lactating women.

The following side effects are diagnosed: nausea, abdominal pain, dizziness and headaches, palpitations, the appearance of an itchy rash. They appear rarely, the drug is usually well tolerated, and reviews from patients and cardiologists are positive.

Conclusion

A large number of Preductal substitutes are produced, their cost depends on the manufacturer. Each patient can choose a suitable analogue. Other medications are widely available in pharmacies. Preductal analogues are convenient because they allow all patients to receive the necessary treatment at an affordable price.

Source: https://medanalogi.com/p/preduktal.html

Cheap analogues and substitutes for the drug Preductal: list with prices

Coronary heart disease is one of the most common diseases of the cardiovascular system. A pathological process in which blood flow in the coronary arteries is disrupted, causing the myocardium to suffer, is also called coronary heart disease.

The drug preductal is able to effectively increase oxygen in the nerve cells of the brain and heart muscle by improving energy metabolism in them. The active ingredient in the medication is trimetazidine. It increases intracellular acidosis, minimizes myocardial damage, without affecting hemodynamics.

These heart pills are safe to use even in patients with regular angina. For children under 18 years of age, use is prohibited; during pregnancy, treatment with precutal is not recommended.

The medicine is produced in Poland, France and Russia, prices start at 800 rubles. There are many cheap analogues of the drug, both from domestic and foreign manufacturers.

Russian-made analogues

Russian-made trimetazidine tablets, which are close substitutes for preductal, are listed in the table below. The prices of medications explain their popularity among patients.

Ukrainian substitutes

The Ukrainian pharmacological market does not lag behind the domestic one in the production of medications for heart disease.

Ukrainian-made medicines to eliminate symptoms of coronary heart disease, similar to preductal:

1. Kardazin Health. Average price from 120 rubles. The components of the drug help cells suffering from hypoxia restore the necessary oxygen balance. The cost of the medicine is cheaper than the price of the preductal, but the effectiveness is similar.
2. Carduktal. Average price from 100 rubles. Antianginal and anti-ischemic agent. Positively affects energy metabolism in cells.
3. Triductan MV. Average price from 6 rubles. The cheapest synonym for preductal. It has an identical element in the base of the active substance.
4. Tricard. Average price from 80 rubles. The composition of the medicine contains trimetazidine. Cardiological remedy for the treatment of regular angina pectoris. Prohibited during pregnancy and lactation.

Belarusian generics

The list of Belarusian generics offers medications similar to the preductal in terms of pharmacological action and indications for use. When choosing what to replace the original drug with, pay attention to the following synonyms:

• Trimetazidine. Antianginal drug, which is the basis of the drug Preductal. Produced by many pharmaceutical companies under the direct name. The price for tablets is from 120 rubles.
• Three Zidine. Like other drugs containing trimetazidine, this medicine does not relieve angina. Its main function is to eliminate external symptoms. Price per package – from 330 rubles.
• Trimitard MV. The medication normalizes the metabolic process of cells suffering from hypoxia. Available in tablet form. Price for 60 tablets – 420 rubles.

Other foreign analogues

Imported analogues of preductal are represented by a wide range of cardiac drugs. Modern pharmacology offers many identical drugs based on trimetazidine. All of them are used when necessary to eliminate external manifestations of coronary heart disease, angina pectoris and vascular disorders.

Let's look at the most famous of them:

• Trimetazidine perfectly improves blood circulation, reduces the frequency and severity of angina attacks, and stops the development of a heart attack.
• Numerous positive reviews about the use of the drug Preductal and its analogues encourage pharmaceutical companies to release new drugs.
• Despite the apparent similarity of medications for the treatment of coronary artery disease, self-prescription of drugs is not allowed.

Source: https://LadyTrand.ru/lekarstva/preduktal-analogi-spisok.html

Cheap analogues and close substitutes for the drug Preductal: list with prices

Preductal is indicated for the treatment of coronary heart disease. The drug has a positive effect on the cardiovascular system, enriches the nerve cells of the brain with oxygen, restoring normal blood flow.

The active ingredient is trimetazidine, which helps to increase intracellular acidosis without affecting hemodynamics.

The list of contraindications includes pregnant and lactating women, as well as children. The medicine is approved for use from 18 years of age.

Its price varies from 800 to 1200 rubles depending on the country of manufacture. Read what cheap analogues of Preductal are made in Russia and abroad.

Russian-made analogues

Domestic companies offer to purchase drugs with a similar list of indications. Among Russian-made generics you can find close substitutes and antianginal drugs with a different composition.

You can see popular analogues in the table:

Rimecor is a close substitute in composition, which does not differ in the instructions for use of the original product.

All medications are indicated for the treatment of coronary heart disease. The cheapest option would be Triducard, which costs only 100 rubles.

Ukrainian generics

Unlike Russian synonyms, Ukrainian-made drugs can be purchased cheaper.

Depending on the form of release and indications for use, you can purchase medicines in the range from 10 to 120 rubles.

Among the most purchased generics from the Ukrainian manufacturer:

• Triductan MV. Budget option Preductal. The active ingredient is trimetazidine.

  The tablets help enrich brain cells with oxygen and help strengthen the walls of the myocardium. Price – 10 rubles.

• Carductal. An anti-ischemic drug aimed at normalizing myocardial metabolism.

  Positively affects the functioning of the cardiovascular system. The average price in a pharmacy is 110 rubles per package.

• Tricard. A similar structural prototype approved for the treatment of regular angina.

  The drug does not differ in instructions for use from the original drug, and is also prohibited for women during pregnancy and children. The cost per package is 70 rubles.

• Kardazin Health. A drug of similar action with an antihypoxic effect.

  Belongs to the group of antianginal drugs, indicated for the treatment of coronary disease and vascular pathologies.

  Enriches the cells of the cardiovascular system with oxygen. The average cost is 120 rubles.

The cheapest Ukrainian-made antianginal drug is Triductan MV; you can buy a pack of tablets at a pharmacy for even less than 10 rubles.

The only drawback of the above products is their frequent absence from sale in Russian pharmacies.

Other foreign substitutes

Imported pharmaceutical companies may also offer low-cost options for anti-ischemic drugs.

You can buy medicines in the range from 100 to 400 rubles. Imported medicines are of high quality.

The list of drugs in demand among patients includes:

• Predisin. Polish medicine developed to relieve angina attacks.

  Active substances promote normal blood flow and help speed up myocardial metabolism. The cost of a Polish-made medicine is 540 rubles.

• Trimetazid. The active ingredient is trimetazidine. The medicine is indicated for the treatment of vascular pathologies, dizziness and angina.

  Indicated for the treatment of ischemic disease of the cardiovascular system. Price – 260 rubles.

• Precard. An antianginal agent with a similar effect to the original drug.

  It is also contraindicated for women during pregnancy and lactation, and is not prescribed for children. The average price is 400 rubles.

• Trimetazidine. A medical product containing the same active ingredient. Release form: tablets.

  The Belarusian-made drug is intended for the treatment of coronary heart disease.

  This drug is a close substitute for Preductal. Price – 100 rubles per package.

Among anti-ischemic medications there are cheap and expensive ones. A budget option of foreign production is Trimetazidine.

Before use, carefully read the instructions, pay attention to the list of contraindications and side effects.

Attention! Replacing the original drug with a close substitute that is cheaper should be subject to the permission of the attending physician.

Source: https://LadyVapm.com/analogi/preduktal-deshevyie-spisok-ceny.html

Preductal analogues

• Rimecore are: coronary heart disease: prevention of angina attacks (in complex therapy); chorioretinal vascular disorders; dizziness of vascular origin; cochleo-vestibular disorders of ischemic nature (tinnitus, hearing impairment).
• Cardioleptin recommended as a dietary supplement - an additional source of flavonoids and phenolic compounds. Cardioleptin used as a means of improving the functional state of the cardiovascular system, protecting the heart muscle from ischemic and post-ischemic damage in a number of diseases: coronary heart disease (angina pectoris, myocardial infarction, atherosclerotic cardiosclerosis); heart rhythm disturbances; heart failure of any origin; arterial hypertension; myocardial dystrophy; cardiomyopathy; myocarditis; heart defects.
• A drug Bisoprolol indicated for use in arterial hypertension; IHD: for the prevention of angina attacks.
• Indications for use of the drug Triducard MV are: coronary heart disease: prevention of angina attacks (in complex therapy); chorioretinal vascular disorders; dizziness of vascular origin; cochleovestibular disorders of ischemic nature (tinnitus, hearing impairment).
• Indications for use of the drug Vasalamin are: general and cerebral atherosclerosis, coronary heart disease, systemic and local microcirculation disorders, dyscirculatory encephalopathy, consequences of acute cerebrovascular accident, hypercholesterolemia, Raynaud's disease, extensive geriatric practice.
• A drug Karvelis used to maintain the cardiovascular system during nervous tension (stress), neurocirculatory dystonia, cardiac neuroses, in the complex treatment of arterial hypertension I-II stages, angina pectoris I-II degrees, arrhythmias in stressful situations and to improve well-being during nervous excitement in adults.
• Dipyridamole intended for: - Treatment and prevention of ischemic cerebral circulatory disorders, dyscirculatory encephalopathy. — Prevention of arterial and venous thrombosis and their complications, prevention of thromboembolism after heart valve replacement surgery. — Prevention of placental insufficiency during complicated pregnancy. — As part of complex therapy for any microcirculation disorders. — As an interferon inducer and immunomodulator for the prevention and treatment of influenza, ARVI.
• Indications for use of the drug Vedicardol are: - Arterial hypertension (in monotherapy and combination with diuretics); — Chronic heart failure (as part of combination therapy); — Coronary heart disease: stable angina.
• Indications for use of the drug Niperten are: arterial hypertension; IHD: prevention of angina attacks; chronic heart failure.
• Magnerot used in complex treatment and for the prevention of: myocardial infarction, coronary heart disease, atherosclerosis, hypertension, spastic conditions (including muscle cramps). Treatment of supraventricular heart rhythm disturbances, left ventricular failure, lipid and carbohydrate metabolism disorders.
• A drug Amlessa intended for the treatment of diseases: arterial hypertension and/or coronary heart disease (if treatment with perindopril and amlodipine is necessary).
• A drug Mildronate used in complex therapy of coronary heart disease (angina pectoris, myocardial infarction); chronic heart failure and dyshormonal cardiomyopathy, as well as in the complex treatment of acute and chronic disorders of the blood supply to the brain (stroke and cerebrovascular insufficiency). Hemophthalmos and retinal hemorrhages of various etiologies, thrombosis of the central retinal vein and its branches, retinopathy of various etiologies (diabetic, hypertensive). Reduced performance; mental and physical overload (including among athletes). Withdrawal syndrome in chronic alcoholism (in combination with specific therapy for alcoholism).
• A drug CardioActive Taurine used in complex therapy: - cardiovascular failure of various etiologies; - intoxication caused by taking cardiac glycosides; — diabetes mellitus type 1; — type 2 diabetes mellitus, including those with moderate hypercholesterolemia.
• Kristal used for hypertension, atherosclerosis, obliterating endarteritis, discirculatory encephalopathies, coronary heart disease, in the complex treatment of osteochondrosis, arthrosis, osteoporosis.
• Indications for use of the drug Bisogamma are: arterial hypertension; coronary heart disease: prevention of angina attacks.
• Indications for use of the drug Cardionate are: - Reduced performance; mental and physical (including among athletes) overload. — As part of complex therapy: coronary heart disease (angina pectoris), chronic heart failure, cardialgia against the background of dyshormonal myocardial dystrophy. — As part of complex therapy: cerebrovascular accident (ischemic stroke, chronic cerebrovascular insufficiency). — Withdrawal state in chronic alcoholism (as part of complex specific therapy).
• Indications for use of the drug Concor are: arterial hypertension; coronary heart disease: prevention of angina attacks; chronic heart failure.
• A drug Amlodipine used for arterial hypertension, coronary heart disease (stable and vasospastic angina).
• Indications for use of the drug Binelol are: arterial hypertension; IHD: prevention of angina attacks; chronic heart failure (as part of combination therapy).
• A drug Thrombopol used to suppress platelet aggregation. In the prevention of coronary heart disease, including: - to reduce the risk of morbidity and mortality in patients who have had myocardial infarction - for secondary prevention of stroke - to reduce morbidity and mortality in stable and unstable angina - to reduce the risk of acute myocardial infarction in the presence of cardiac -vascular risk factors (for example, diabetes mellitus, hyperlipidemia, arterial hypertension, obesity, smoking, old age) In the prevention of other diseases characterized by the formation of blood clots in blood vessels: - for the prevention of deep vein thrombosis and pulmonary embolism during prolonged immobilization (for example, after major surgery) - to reduce the risk of acute myocardial infarction in the presence of cardiovascular risk factors (for example, diabetes mellitus, hyperlipidemia, hypertension, obesity, smoking, old age)
• Indications for use of the drug Prestance are: arterial hypertension and/or coronary heart disease (CHD): stable angina pectoris in patients who require therapy with perindopril and amlodipine.
• Indications for use of the drug Aritel are: chronic heart failure; arterial hypertension; coronary heart disease - prevention of attacks of stable angina.
  • Aritel price 11 offers from 62 to 196 rubles
  • Instructions for use
• Indications for use of the drug Presartan are: arterial hypertension; chronic ischemic heart disease, accompanied by symptoms of heart failure (as part of combination therapy with diuretics and cardiac glycosides).
• Indications for use of the drug Predisin are: coronary heart disease - prevention of angina attacks (in complex therapy); cochleovestibular disorders of ischemic nature (dizziness, tinnitus, hearing impairment).
• Indications for use of the drug Trimetazidine are: - Coronary heart disease: prevention of angina attacks (as part of complex therapy). — Cochleovestibular disorders of ischemic nature, such as dizziness, tinnitus, hearing impairment. — Chorioretinal vascular disorders.
• A drug Trimectal MV intended for use in the treatment of coronary heart disease: prevention of attacks of stable angina (as part of complex therapy).
• Indications for use of the drug Simvastatin are: - Hypercholesterolemia: - Primary hypercholesterolemia (type IIa and IIb) with the ineffectiveness of low-cholesterol diet therapy and other non-drug measures (physical activity and weight loss) in patients with an increased risk of coronary atherosclerosis; combined hypercholesterolemia and hypertriglyceridemia, not corrected by a special diet and physical activity. — Coronary heart disease: for the prevention of myocardial infarction, to reduce the risk of death, reduce the risk of cardiovascular disorders (stroke or transient ischemic attacks), slow the progression of coronary atherosclerosis, reduce the risk of revascularization procedures.
• Indications for use of the drug Dilaprel are: - essential hypertension; - chronic heart failure (as part of combination therapy, in particular in combination with diuretics); - diabetic or non-diabetic nephropathy, preclinical or clinically pronounced stages, including with severe proteinuria, especially when combined with arterial hypertension; - reducing the risk of myocardial infarction, stroke or cardiovascular mortality in patients with high cardiovascular risk: - in patients with confirmed coronary heart disease, a history of myocardial infarction or without it, including patients who have undergone percutaneous transluminal coronary angioplasty, aortic coronary bypass surgery, - in patients with a history of stroke, - in patients with occlusive lesions of peripheral arteries, - in patients with diabetes mellitus with at least one additional risk factor (microalbuminuria, arterial hypertension, increased plasma concentrations of TC, decreased plasma concentrations of cholesterol- HDL, smoking); - heart failure that developed during the first few days (from the second to the ninth day) after acute myocardial infarction.
• Core Suis Compositum N used in the complex treatment of coronary heart disease: for atherosclerosis of the coronary vessels, the condition after myocardial infarction; for heart failure, cardiac arrhythmia, hypertension, cardiomyopathy, cardiodystrophy, endocarditis, angina pectoris, chronic rheumatic heart disease, myocardial hypertrophy, emphysema, cor pulmonale, pulmonary circulation disorder, obliterating endarteritis, gastrocardial syndrome.
• Meldonat used as part of combination therapy in the following cases: - cardiovascular diseases: stable angina pectoris, chronic heart failure (NYHA I-III functional class), cardiomyopathy, functional disorders of the cardiovascular system; - acute and chronic cerebrovascular accidents; - reduced performance, physical and psycho-emotional overload;

  - recovery period after cerebrovascular accidents, head injuries and encephalitis.

  • Meldonat price prices not found
  • Instructions for use
• • Klopix Forte price prices not found
  • Instructions for use
• Indications for use of the drug Propranolol are: arrhythmia, arterial hypertension, ischemic heart disease, hypertrophic cardiomyopathy, myocardial dystrophy, neurocirculatory dystonia, thyrotoxicosis, liver cirrhosis, withdrawal syndrome, migraine (prevention), weakness of labor.
• For adults Carmetadine indicated for the symptomatic treatment of stable angina pectoris with insufficient effectiveness or intolerance to first-line antianginal drugs.
  • Carmetadine price prices not found
  • Instructions for use
• Indications for use of the drug Nebiworld are: - arterial hypertension; — coronary heart disease: prevention of angina attacks; - chronic heart failure (as part of combination therapy).
  • Nebiworld price prices not found
  • Instructions for use
• Indications for use of the drug Ripronate are: - complex therapy of coronary artery disease (angina pectoris, myocardial infarction), chronic heart failure and dyshormonal cardiomyopathy; — complex therapy of acute and chronic cerebrovascular accidents (cerebral strokes and cerebrovascular insufficiency); - hemophthalmos and retinal hemorrhages of various etiologies, thrombosis of the central retinal vein and its branches, retinopathy of various etiologies (diabetic, hypertensive); - decreased performance, physical overstrain (including among athletes); - bronchial asthma and chronic bronchitis (as an immunomodulator in combination therapy); — postoperative period to speed up rehabilitation; — withdrawal syndrome in chronic alcoholism (in combination with specific therapy for alcoholism).
  • Ripronate price prices not found
  • Instructions for use
• A drug Lopigrol intended for use for the prevention of ischemic disorders in patients with severe atherosclerosis, including: - after myocardial infarction, ischemic stroke or newly diagnosed peripheral arterial disease; - in acute coronary syndrome without ST segment elevation (unstable angina or myocardial infarction without a pathological Q wave) in combination with acetylsalicylic acid; - in acute coronary syndrome with ST segment elevation (acute myocardial infarction) in combination with acetylsalicylic acid, receiving drug treatment, including thrombolytic therapy; — microcirculation disorders of any type as part of complex therapy.
  • Lopigrol price prices not found
  • Instructions for use
• Indications for use of the drug Startum are: - neuritis, neuropathy (with diabetes, pernicious anemia, etc.); - neuralgia of various origins; - myalgia, sciatica; - lumbago, radiculitis; - bursitis, tendinitis; - coronary heart disease, myocarditis, myocardiopathy.
  • Startum price prices not found
  • Instructions for use
• Indications for use of the drug Risoprol are: - arterial hypertension; - coronary heart disease (angina pectoris); - post-infarction period; - rhythm disturbances (sinus tachycardia, supraventricular and ventricular extrasystole); - arrhythmias due to mitral valve prolapse, thyrotoxicosis; - chronic heart failure.
  • Risoprol price prices not found
  • Instructions for use
• A drug Rhythmocore used for the treatment of diseases and conditions accompanied by hypomagnesemia and hypokalemia (in complex treatment regimens): - coronary heart disease; - heart rhythm disturbances (atrial and ventricular extrasystolic arrhythmia); — vegetative-vascular dystonia; - myocardiopathy; — disturbance of electrolyte metabolism (in order to correct the level of magnesium and potassium ions) — chronic fatigue syndrome.
  • Rhythmocore price prices not found
  • Instructions for use
• Indications for use of the drug Lekoptin are: - Coronary heart disease, including stable angina pectoris; unstable angina (progressive angina, rest angina) vasospastic angina (variant angina, Prinzmetal's angina) post-infarction angina in patients without heart failure, unless beta-blockers are indicated. - Arrhythmias: paroxysmal supraventricular tachycardia, atrial flutter / fibrillation with rapid AV conduction (except for Wolff-Parkinson-White syndrome (WPW). - Arterial hypertension.
  • Lekoptin price prices not found
  • Instructions for use
• • ATF price 7 offers from 244 to 352 rubles
  • Instructions for use
• • Bisoprolol KRKA price prices not found
  • Instructions for use
• • Bisoprolol Sandoz price prices not found
  • Instructions for use
• • Bisoprolol-Astrapharm price prices not found
  • Instructions for use
• • Bisoprolol-Ratiopharm price prices not found
  • Instructions for use
• • Carduktal price prices not found
  • Instructions for use
• • Kratal price prices not found
  • Instructions for use

This table is based on data collected from the resources of pharmaceutical companies producing these drugs. The average prices for drugs with a minimum dosage dispensed from Russian pharmacies in 2020 are indicated. Why are analogues cheaper than Preductal? A lot of time and money are spent on the production of the chemical formula of a new drug, and tests are carried out. The pharmaceutical company then buys the patent, then spends money on advertising and releases it for sale. The manufacturer sets a high price for the drug in order to quickly recoup the investment. Other medications that are similar in composition, less well-known but time-tested, remain several times cheaper. Share your experience

Did Preductal help you with your treatment?

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Coronary heart disease is one of the most common diseases of the cardiovascular system. A pathological process in which blood flow in the coronary arteries is disrupted, causing the myocardium to suffer, is also called coronary heart disease.

The drug preductal is able to effectively increase oxygen in the nerve cells of the brain and heart muscle by improving energy metabolism in them. The active ingredient in the medication is trimetazidine. It increases intracellular acidosis, minimizes myocardial damage, without affecting hemodynamics.

These heart pills are safe to use even in patients with regular angina. For children under 18 years of age, use is prohibited; during pregnancy, treatment with precutal is not recommended.

The medicine is produced in Poland, France and Russia, prices start at 800 rubles. There are many cheap analogues of the drug, both from domestic and foreign manufacturers.

Russian-made analogues

Russian-made trimetazidine tablets, which are close substitutes for preductal, are listed in the table below. The prices of medications explain their popularity among patients.

Ukrainian substitutes

The Ukrainian pharmacological market does not lag behind the domestic one in the production of medications for heart disease.

Ukrainian-made medicines to eliminate symptoms of coronary heart disease, similar to preductal:

1. Kardazin Health. Average price from 120 rubles. The components of the drug help cells suffering from hypoxia restore the necessary oxygen balance. The cost of the medicine is cheaper than the price of the preductal, but the effectiveness is similar.
2. Carduktal. Average price from 100 rubles. Antianginal and anti-ischemic agent. Positively affects energy metabolism in cells.
3. Triductan MV. Average price from 6 rubles. The cheapest synonym for preductal. It has an identical element in the base of the active substance.
4. Tricard. Average price from 80 rubles. The composition of the medicine contains trimetazidine. Cardiological remedy for the treatment of regular angina pectoris. Prohibited during pregnancy and lactation.

Belarusian generics

The list of Belarusian generics offers medications similar to the preductal in terms of pharmacological action and indications for use. When choosing what to replace the original drug with, pay attention to the following synonyms:

• Trimetazidine. Antianginal drug, which is the basis of the drug Preductal. Produced by many pharmaceutical companies under the direct name. The price for tablets is from 120 rubles.
• Three Zidine. Like other drugs containing trimetazidine, this medicine does not relieve angina. Its main function is to eliminate external symptoms. Price per package – from 330 rubles.
• Trimitard MV. The medication normalizes the metabolic process of cells suffering from hypoxia. Available in tablet form. Price for 60 tablets – 420 rubles.

Other foreign analogues

Imported analogues of preductal are represented by a wide range of cardiac drugs. Modern pharmacology offers many identical drugs based on trimetazidine. All of them are used when necessary to eliminate external manifestations of coronary heart disease, angina pectoris and vascular disorders.

Let's look at the most famous of them:

Trimetazidine perfectly improves blood circulation, reduces the frequency and severity of angina attacks, and stops the development of a heart attack.

Numerous positive reviews about the use of the drug Preductal and its analogues encourage pharmaceutical companies to release new drugs.

Despite the apparent similarity of medications for the treatment of coronary artery disease, self-prescription of drugs is not allowed.

Related Posts

This page provides a list of all analogues of Preductal by composition and indication for use. A list of cheap analogues, and you can also compare prices in pharmacies.

• The cheapest analogue of Preductal:
• The most popular analogue of Preductal:
• ATX classification: Trimetazidine
• Active ingredients/composition: trimetazidine dihydrochloride

Cheap analogues of Preductal

When calculating the cost cheap analogues of Preductal the minimum price was taken into account, which was found in the price lists provided by pharmacies

Popular analogues of Preductal

The list of drug analogues based on statistics of the most requested drugs

All analogues of Preductal

Analogues in composition and indications for use

The above list of drug analogues, which indicates Preductal substitutes, is the most suitable because they have the same composition of active ingredients and coincide in indications for use

Analogues by indication and method of use

Different composition, may have the same indication and method of use

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Preducted price

Preductal instructions

INSTRUCTIONS
on the use of the product
PREDUCTAL

pharmachologic effect
The active ingredient of Preductal is trimetazidine dihydrochloride. Has anti-ischemic and antianginal effects. Preductal is a modified-release trimetazidine tablet (extended release). Preductal - short-acting tablets. Trimetazidine helps stabilize energy metabolism in cells in the presence of ischemia or hypoxia by preventing a decrease in the level of adenosine triphosphate inside cells. Thanks to this, normalization of the functioning of ion pumps and sodium-potassium transmembrane flow is observed while maintaining cell homeostasis. The active ingredient Preductal partially inhibits the oxidation of fatty acids due to the suppression of 3-CAT - long-chain 3-ketoacyl CoA thiolase. This normalizes energy metabolism in cardiac cells, causes an increase in glucose oxidation and improves glucose oxidation associated with glycolysis, which protects myocardiocytes from ischemic damage.

Preductal also enhances phospholipid metabolism and the incorporation of phospholipids into cell membranes, due to which stabilization of membranes is observed under conditions of ischemia or hypoxia. In hypoxia or ischemia, the most optimal energy metabolism is glucose oxidation; trimetazidine switches metabolism from fatty acid oxidation to a more favorable pathway - glucose oxidation, which explains the antianginal effect of Preductal.

Thanks to the dosage form with modified release of trimetazidine, Preductal has an optimal pharmacokinetic profile. During the day, the plasma concentration of the active substance Preductal remains at least 75% of the maximum for 11 hours. Compared to short-acting Preductal, the minimum effective concentration in blood plasma is 31% higher. This ensures stable effectiveness of the drug over 24 hours, including the early hours of the day, when the likelihood of cardiovascular complications is highest. Thus, prolonged Preductal provides a round-the-clock reliable cardioprotective and anti-ischemic effect.

After oral administration, the equilibrium concentration of trimetazidine in the blood plasma is achieved no later than 60 hours after the start of use. The pharmacokinetic characteristics of modified-release tablets are not affected by food intake. The volume of distribution indicator is 4.8 l/kg. Only a small part of the active substance is combined with plasma proteins - approximately 16%. It is eliminated predominantly in unchanged form by the kidneys. The half-life in young healthy volunteers is 7 hours, in people over 65 years of age – 12 hours. No dosage adjustment is required in the elderly.

Application in cardiology
In clinical studies with a placebo-controlled, double-blind design, trimetazidine was shown to increase the threshold for myocardial ischemic injury and ischemia, as assessed by the following criteria:

• change in exercise tolerance;
• studying the severity and time of appearance of ST segment elevation on the ECG;
• degree of increase in coronary reserve;
• reducing the need to prescribe nitroglycerin in usual doses;
• reducing the severity and frequency of angina attacks.

In clinical studies, Preductal was prescribed both as part of complex treatment and as monotherapy; both in the treatment of chronic and acute conditions. It has been established that during hypoxia and ischemia, trimetazidine improves energy metabolism in neurosensory organs and the myocardium, prevents changes in ionic transmembrane flows that are associated with ischemia, reduces the severity of acidosis within cells, reduces the ability of polymorphonuclear neutrophil granulocytes to infiltrate and migrate into reperfused and ischemic myocardium . The drug also reduces the severity of ischemic-associated disorders and significantly reduces the size of myocardial infarctions that are caused experimentally. Does not change hemodynamic parameters.
In controlled clinical trials in patients with angina pectoris, trimetazidine has been shown to delay the onset of ischemia by increasing coronary reserve from approximately the 15th day of therapy under conditions of increased stress; significantly reduces the incidence of angina attacks; limits sharp fluctuations in blood pressure without clinically significant changes in heart rate; helps reduce the dosage of nitroglycerin. Clinical studies of trimetazidine for 2 months under conditions of dosed physical activity revealed that when used at a dosage of 35 mg in combination with atenolol (50 mg/day), there is an increase in the time interval from ischemia to visible changes in the ST segment (by 1 mm) compared with placebo already 12 hours after administration.

Application in otolaryngological practice
In clinical studies of a placebo-controlled, double-blind design, Preductal was shown to effectively reduce the frequency, duration and severity of dizziness attacks due to its anti-ischemic effect and protection of vestibular neurons from excitotoxic amino acids that have a toxic effect. The drug reduces the frequency and intensity of tinnitus and reduces the likelihood of its recurrence. Expands the perceived sound range in case of perceptual deafness.

Application in ophthalmological practice
When taking the drug, an increase in the b-wave amplitude is recorded on the electroretinogram, which is an indicator of ischemia of the organ of vision. When taking Preductal, the prognosis for restoration of the functional activity of the retina improves, the field of vision increases and visual acuity increases due to the improvement in the morphological structure of the retina and macula after taking trimetazidine (including cases of degenerative age-related changes).

Indications for use
Cardiology practice
Prevention and treatment of angina pectoris in combination with other drugs or as monotherapy for a long time.
Ophthalmological practice
Ischemic chorioretinal disorders.
Otolaryngology practice
Ischemic vestibulo-cochlear disorders (tinnitus, dizziness, decreased hearing acuity).

Mode of application
Prescribed for a long time, 1 tablet 2 times a day in the morning and evening (Preductal MR) or 1 tablet 2-3 times a day (Preductal) with meals. The duration of therapy is determined by the attending physician individually. If necessary, the treatment regimen can be revised after 3 months.

Side effects
In most cases, the drug is well tolerated by patients. Gradation of the following side effects: very common - 1/10, uncommon - 1/1000, but not more than 1/100, rare - 1/10,000, but not more than 1/1000, isolated - ≤1/10,000, frequent - 1 /100, but not more than 1/10.
Gastrointestinal tract: diarrhea, pain in the epigastric region, nausea and/or vomiting, dyspeptic symptoms (often).
Nervous system: dizziness and headache (frequent); extrapyramidal symptoms, especially with concomitant Parkinson's disease - muscle rigidity, akinesia, tremor (in isolated cases, relieved by drug withdrawal).
Skin and skin appendages: itching, rash, urticaria (frequent), facial skin flushing (rare).
Cardiovascular system: orthostatic hypotension (rare).
Other: asthenia (often).

Contraindications
Breastfeeding period;
hypersensitivity to trimetazidine or other ingredients of Preductal.

Pregnancy
It is not recommended to prescribe Preductal to pregnant and nursing mothers due to the lack of data on the safety of trimetazidine.

Drug interactions
No data provided.

Overdose
The therapeutic dosage range is quite wide, so exceeding the dose with the development of toxic effects is unlikely. In some cases, a decrease in peripheral vascular resistance may be observed, which leads to flushing of the facial skin or arterial hypotension. Treatment is symptomatic.

Release form
Preductal - Modified release film-coated tablets, 35 mg. There are 60 tablets in a blister pack.
Preductal – 20 mg tablets, 60 tablets per pack.

Storage conditions
At room temperature.

Compound
Active substance (1 tablet): trimetazidine dihydrochloride 35 mg.
Auxiliary components: hypromellose 4000, calcium hydrogen phosphate dihydrate, magnesium stearate, povidone, glycerol, titanium dioxide (E171), red iron oxide (E172), colloidal anhydrous silicon dioxide, macrogol.

Active substance (1 tablet): trimetazidine dihydrochloride 20 mg.
Excipients: povidone, mannitol, talc, magnesium stearate, titanium dioxide (E171), corn starch, glycerol, macrogol 6000, yellow aluminum varnish FCF S (E110), cochineal aluminum varnish A (E124), hypromellose.

Pharmacological group
Cardiovascular drugs
Medicines used as metabolic correctors

Active substance: Trimetazidine

Additionally
Do not prescribe to children, since there is no data on the safety and effectiveness of Perductal in patients of this age. Do not use to relieve angina attacks - Preductal is prescribed only for basic treatment. Elderly persons do not require dosage adjustment. Does not affect the ability to quickly respond when working with precision tools or driving vehicles.

In this article you can read the instructions for use of the drug Preductal. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Preductal in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Preductal in the presence of existing structural analogues. Use for the treatment of coronary heart disease and the prevention of angina attacks in adults, children, as well as during pregnancy and lactation.

Preductal MV- prevents a decrease in intracellular ATP content by maintaining the energy metabolism of cells in a state of hypoxia. Thus, the drug ensures the normal functioning of membrane ion channels, transmembrane transport of potassium and sodium ions and the preservation of cellular homeostasis.

Trimetazidine (the active ingredient of the drug Preductal) slows down the oxidation of fatty acids due to the selective inhibition of long-chain 3-ketoacetyl-CoA thiolase, which leads to increased glucose oxidation and restoration of the coupling between glycolysis and oxidative decarboxylation and protects the myocardium from ischemia. The switch from fatty acid oxidation to glucose oxidation underlies the antianginal effect of trimetazidine.

It has been experimentally confirmed that Preductal has the following properties:

• supports energy metabolism of the heart and neurosensory organs during ischemia;
• reduces the amount of intracellular acidosis and the degree of changes in the transmembrane ion flow that occurs during ischemia;
• reduces the level of migration and infiltration of polynuclear neutrophils in ischemic and reperfusion tissues of the heart;
• reduces the size of myocardial damage;
• does not have a direct effect on hemodynamic parameters.

In patients suffering from angina, Preductal:

• increases coronary reserve, thereby slowing down the development of ischemia caused by physical activity, starting from the 15th day of therapy;
• limits sharp fluctuations in blood pressure caused by physical activity without any significant changes in heart rate;
• significantly reduces the frequency of angina attacks and the need for short-acting nitroglycerin;
• improves contractile function of the left ventricle in patients with ischemic dysfunction.

In clinical studies lasting 2 months, it was shown that the addition of Preductal MB at a dose of 35 mg to therapy with atenolol at a dose of 50 mg after 12 hours led to a significant delay in the onset of ischemic depression of the ST segment during stress tests.

Pharmacokinetics

After taking the drug orally, Preductal is quickly absorbed. Food intake does not affect the pharmacokinetic properties of the drug. It is excreted from the body mainly by the kidneys unchanged.

Indications

• cardiology: long-term therapy of coronary artery disease, prevention of attacks of stable angina (monotherapy or as part of combination therapy);
• ENT diseases: treatment of cochleo-vestibular disorders of ischemic nature, such as dizziness, tinnitus, hearing impairment;
• ophthalmology: chorioretinal disorders with an ischemic component.

Release forms

Film-coated tablets 20 mg and 35 mg (Preductal MR).

Instructions for use and dosage regimen

Preductal MB is prescribed 1 tablet 2 times a day during meals in the morning and evening. The duration of therapy is determined individually.

I take the tablets whole orally, without chewing and with water.

Side effect

• stomach ache;
• diarrhea;
• dyspepsia;
• nausea, vomiting;
• dizziness;
• headache;
• extrapyramidal symptoms (tremor, rigidity, akinesia), reversible after discontinuation of the drug;

feeling of heartbeat;

extrasystole;

tachycardia;

pronounced decrease in blood pressure;

orthostatic hypotension, which may be accompanied by general weakness, dizziness or loss of balance, especially when taking antihypertensive drugs simultaneously;

• rushes of blood to the skin of the face;
• skin rash;
• hives;
• asthenia.

Contraindications

• severe renal failure (creatinine clearance less than 15 ml/min);
• hypersensitivity to the components of the drug;
• children and adolescents under 18 years of age.

Use during pregnancy and breastfeeding

Experimental studies have not established the teratogenic effect of trimetazidine. However, due to the lack of clinical data, the drug is not recommended for use during pregnancy.

It is not known whether trimetazidine is excreted in breast milk. Therefore, if it is necessary to prescribe the drug during lactation, breastfeeding should be stopped.

Use in children

Due to the lack of sufficient clinical data, it is not recommended to prescribe the drug to children and adolescents under the age of 18 years.

Use in elderly patients

Preductal MB should be prescribed with caution to elderly patients over 75 years of age, in whom increased exposure may occur.

special instructions

Preductal MV is not intended for the relief of angina attacks and is not indicated for the initial course of treatment of unstable angina or myocardial infarction in the prehospital stage or in the first days of hospitalization.

If an attack of angina occurs, treatment (drug therapy or revascularization procedure) should be reviewed and adapted.

Preductal MB can cause or worsen symptoms of parkinsonism (tremor, akinesia, increased tone), so patients should be regularly monitored, especially the elderly. In doubtful cases, patients should be referred to a neurologist for appropriate examination.

If movement disorders appear, such as symptoms of parkinsonism, restless legs syndrome, tremor, instability in the Romberg position and unsteadiness of gait, Preductal MB should be permanently discontinued.

Such cases are rare and symptoms usually resolve after discontinuation of therapy: in most patients, within 4 months after discontinuation of the drug. If symptoms of parkinsonism persist more than 4 months after discontinuation of the drug, you should consult a neurologist.

There may be cases of falls associated with instability in the Romberg position and “wobbly” gait or a pronounced decrease in blood pressure, especially in patients taking antihypertensive drugs.

Preductal MB should be prescribed with caution to patients in whom increased exposure may occur:

• with moderate and severe renal failure;
• in elderly patients over 75 years of age.

Impact on the ability to drive vehicles and operate machinery

Clinical studies did not reveal the effect of the drug Preductal MB on hemodynamic parameters, however, during the period of post-registration use, cases of dizziness and drowsiness were observed, which may affect the ability to drive vehicles and perform work that requires an increased speed of physical and mental reactions.

Drug interactions

Drug interactions with Preductal MR have not been described.

Analogues of the drug Preductal

Structural analogues of the active substance:

• Angiosil retard;
• Antisthene;
• Antisten MV;
• Vero-Trimetazidine;
• Deprenorm MV;
• Carditrim;
• Metaguard;
• Predisin;
• Precard;
• Rimecore;
• Rimecor MV;
• Triducard;
• Trimectal;
• Trimectal;
• Trimetazide;
• Trimetazidine;
• Trimetazidine MB;
• Trimetazidine-Biocom MV;
• Trimetazidine-ratiopharm;
• Trimetazidine dihydrochloride;
• Trimitard MV.

If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.