Norfloxacin for diseases of the genitourinary system. Norfloxacin tablets: recommendations for use, contraindications Norfloxacin dosage for children

Norfloxacin is a drug with an antibacterial effect. The drug Norfloxacin belongs to drugs with pronounced antimicrobial activity and uroseptics. It has antibacterial properties. Weakens the microbial DNA chain.

For the prevention and treatment of cystitis, our readers recommend Father George’s Monastic tea. It consists of 16 useful medicinal herbs that are extremely effective in treating cystitis, bladder inflammation and urinary tract diseases.

>>>Differentsed in bacteria-killing properties

Description

This drug is almost completely absorbed from the digestive organs. If the medicine is taken on a full stomach, this process slows down.

Within an hour after its use, the required concentration of the active substance in the blood is ensured. Metabolized to a small extent in the liver. It leaves the body with bile and urine.

Norfloxacin is effective for 12 hours. It dissolves freely in fats, making it easily delivered to organs and tissues.

Norfloxacin is effective for 12 hours

Release forms

Norfloxacin drugs have different release forms. Presented in tablet form, eye and ear drops.

1 tablet contains 400 mg of the main substance. In addition, it contains lactose, corn starch, magnesium stearate, talc and other additional components.

The medicine in tablet form is packaged in plastic jars of 10-20 pieces and blisters of 10 pieces. One package includes 1-2 tablets.

Attention!

Chief urologist: “I beg you, don’t take antibiotics. To forget about cystitis as a bad dream you need 2 times a day...

The solution is placed in 5 ml bottles. The container is equipped with a dropper cap, making the drug convenient to use for installations. 1 ml of the product contains 3 mg of norfloxacin and additional components.

Instructions

Tablets are not suitable for combating ureoplasma, nocardia, anaerobic bacteria Norfloxacin is an antibiotic that is prescribed to fight infections caused by microorganisms that are sensitive to it. Its description is confirmed by the fact that it has a strong effect on staphylococci, Escherechia, salmonella, Neisseria, Proteus, hafnia, chlamydia and other pathogens.

Norfloxacin tablets are not suitable for combating ureoplasma, nocardia, and anaerobic bacteria.

The drug is most effective for treating the following diseases:

cystitis; pyelonephritis; prostatitis; urethritis. endometritis; salmonellosis; gonorrhea. The drug is also prescribed to prevent relapses of pathologies of the genitourinary organs. Norfloxicin is used as a preventive measure against sepsis in patients with granulocytopenia. The medicine is effective as a prophylaxis against infections during diagnostic examinations, which involve the use of instruments and during urological operations. Local therapy
The drug is also used in ophthalmology. The drug in drops is used for local therapy. In ophthalmology: for conjunctivitis; blepharitis; dacryocystitis; acute inflammation of the upper eyelid; infections after foreign objects are removed from the conjunctiva or cornea. Norfloxacin is also used in otolaryngology. Norfloxacin, the indications for which are otitis media of varying degrees, is also prescribed for infectious complications after surgical interventions on the eyes and ears. Contraindications The drug has a number of specific contraindications. These include: impaired renal function; late stages of renal failure. If there is an individual intolerance to the active substance of the drug, it is prohibited to use it. The use of Norfloxacin should be discontinued during pregnancy and breastfeeding. The drug should not be taken by patients under 15 years of age. Side effects Adverse reactions from the drug are extremely rare. Adverse reactions from the drug are extremely rare, occurring in about 3% of cases of its use. Most often, side effects occur on the gastrointestinal tract, central nervous system and skin. The negative effect of the drug manifests itself in the form of nausea, lack of appetite, diarrhea, dysbacteriosis, and abdominal pain. In some cases, indicators may be detected in the blood that indicate increased liver function. As for the central nervous system, here the adverse reaction makes itself felt by headache, weakness, insomnia, convulsions, and hallucinations. Elderly patients may experience tinnitus, general deterioration in health, anxiety, and irritability after consuming Norfloxacin. Skin manifestations include rash, itching, swelling, and increased photosensitivity. In some cases, other organs also react negatively to taking this drug. From the urinary system, problems with urination may appear. Sometimes there is bleeding along with the urine and an increase in protein in the urine. The musculoskeletal system is characterized by inflammatory processes in the tendons, their ruptures, and pain in the joints. Quincke's edema and breathing problems cannot be ruled out. A blood test in this case indicates an increase in the level of eosinophils and leukocytes. Therapy Before prescribing a medicine to a patient, the doctor must conduct certain studies and find out whether the flora that caused the disease is sensitive to this drug. There is no need to crush the tablet for administration. It must be swallowed in its original form with water. You need to take the medicine two hours before meals. It is not recommended to use Norfloxacin and medications containing iron, zinc, magnesium and calcium at the same time. It is important that there is a several hour break between taking these medications. If patients have problems with the kidneys and liver, the product should be used with caution, as prescribed by a doctor. The same applies to patients suffering from epilepsy and cerebral atherosclerosis. As soon as pain in the tendons and allergies appear, you should immediately stop taking the medicine. If you have bronchospasms, drinking it is also prohibited. If such phenomena make themselves felt, you should immediately notify your doctor. Treatment with Norfloxacin has its own characteristics. When using this drug to treat a particular pathology, you need to drink enough fluid to prevent the formation of kidney stones. If the drug is used in the form of drops, then before dripping it into the ear or eyes, they should be warmed to body temperature. The external auditory canal must be prepared for the procedure. Only after it has been cleared of purulent formations can you drip the medicine into the ear. At the time of the procedure, the patient needs to tilt his head or lie on his side. After installation, you must remain in this position for several minutes. The ear canal is plugged with a cotton ball. When using eye drops, you need to remember that they impair concentration and visibility for half an hour. That is why you should not drive during this period. Therapy with Norfloxacin is often accompanied by the appearance of photophobia. In this case, you need to wear sunglasses and try not to expose your eyes to bright light. Dosage Norfloxacin instructions for use, which involves taking 1-2 tablets of the medicine at a time, can be taken 1-2 times a day. If the urinary system caused by infection is being treated, the drug can be taken for 3 days. For complex diseases of these organs, therapy can last more than a week. For chronic disease, the course often lasts several months. The exact dosage and duration of therapy should be determined by the doctor, focusing on the specifics of the disease and the general health of the patient. If the maximum dose of the drug has been exceeded, you must immediately rinse the stomach using a tube. You can also direct actions to induce vomiting. After this, symptomatic treatment should be prescribed. Norfloxacin drops are usually combined with systemic antimicrobial treatment. You can drop 1-2 drops of medicine into one eye. The doctor should tell you how often to do this. If the infection is pronounced, the procedure should be performed every 15-30 minutes. For mild cases – up to 6 times a day. To treat trachoma, the medicine is instilled 2-4 times a day for 30-60 days. 2-5 drops of Norfloxacin are dripped into the ear no more than 3 times a day. When the symptoms stop bothering you, therapy should not be stopped. It is necessary to instill the drug for another two days. Norfloxacin for children The drug is strictly contraindicated in patients under 15 years of age. Persons over 15 can use the medicine in the same way as adults. Use during pregnancy and lactation The effect of the active component of the drug on the fetus has not been fully studied. Studies have shown that this medicine can negatively affect the development of joints, so whether it can be given to a patient during pregnancy must be decided by the doctor. Therapy with this drug while breastfeeding is prohibited. If its use is unavoidable, lactation should be interrupted. Treatment of cystitis with Norfloxacin The dose of the drug and duration of therapy for cystitis is prescribed by the doctor. Norfloxacin for cystitis is prescribed quite often due to its effectiveness. The medicine has a detrimental effect on the microflora, which is characteristic of many urinary tract infections. The drug has a bactericidal effect on bacteria that are resistant to antimicrobial drugs. Namely, Pseudomonas aeruginosa, which often provokes inflammation of the bladder. The dose of the drug and duration of therapy for cystitis are prescribed by a urologist or gynecologist. Interaction with other drugs Norfloxacin: Increases the concentration of Theophylline in the blood. If taken along with cyclosporines, it increases the concentration of creatinine in the blood serum. Activates the anticoagulant effect of Warfarin. May result in severe hypotension when using antihypertensive drugs. Slows down the effect of nitrofuran drugs. Prevents the accelerated elimination of caffeine from the body.

Preparations in the form of Almagel and Gastal and those that include calcium salts, zinc, and iron reduce the absorption of Norfloxacin. It is for this reason that it is important that there is a 2-hour gap between the use of this drug and antacids.

If the medicine is prescribed in combination with sleeping pills from a number of barbiturates and anesthetics, you need to monitor your blood pressure and pulse rate. It is also necessary to take into account electrocardiogram data.

Taking Norfloxacin together with Theophylline and non-steroidal drugs with anti-inflammatory effects can lead to convulsions and epileptic seizures.

By secret

Incredible... Chronic cystitis can be cured forever! This time. Without taking antibiotics! That's two. During the week! That's three.

The drug Norfloxacin

Norfloxacin

– a broad-spectrum antibacterial drug from the group of fluoroquinolones, a uroantiseptic. It has a bactericidal effect, destabilizing the DNA chain in the bacterial cell. Used as

antibiotic

20-40% of the drug is well absorbed from the gastrointestinal tract, while food slows down the absorption process. An hour after taking the tablet, the therapeutic concentration of the drug in the blood is achieved. Metabolized slightly in the liver, excreted in bile and urine. The drug lasts for about 12 hours.

Norfloxacin is highly soluble in fats, so it easily penetrates into organs and tissues: kidneys, uterus, ovaries, seminiferous tubules, abdominal organs, bile, breast milk.

Release forms

Norfloxacin is available in tablets and as

eye drops

1 tablet of the drug contains 400 mg of the active substance (norfloxacin), lactose, corn starch, magnesium stearate, talc and other excipients. Tablets are packaged in 10 or 20 pieces in polymer jars or 10 pieces in blisters. One cardboard package contains 1 or 2 blisters (10 or 20 tablets). Drops are produced in 5 ml bottles. The bottle has a dropper cap, which is convenient for use. 1 ml of drops contains 3 mg of active substance and excipients.

Instructions for use of Norfloxacin

Indications for use

Norfloxacin is prescribed for the treatment

infections

Caused by microbes sensitive to it. Most sensitive to the drug:

staphylococci; Escherichia; Salmonella; Neisseria; Protea; Hafnia; Klebsiella; Yersinia; Chlamydia; Legionella; Vibrio cholerae and other pathogens. Insensitive to Norfloxacin: ureaplasma, treponema pallidum, nocardia, anaerobic bacteria (peptococci, peptostreptococci, clostridia, etc.).

Indications for oral use:

Cystitis, pyelonephritis, prostatitis, urethritis and other acute and chronic infections of the urinary system. Gonorrhea. Cervicitis, endometritis. Salmonellosis, shigellosis, traveler's diarrhea. Prevention of relapse of genitourinary tract diseases. Prevention of sepsis in patients with granulocytopenia. Norfloxacin is also prescribed for the prevention of infections during instrumental diagnostic procedures and surgical interventions in urological practice.

The drug is used locally:1. In ophthalmology for treatment:

conjunctivitis; keratitis; blepharitis; blepharoconjunctivitis; dacryocystitis; acute inflammation of the meibomian glands; corneal ulcers; infections after removal of a foreign body from the conjunctiva or cornea; chemical burns. 2. In otolaryngology for treatment:

external otitis; acute and chronic otitis media. And also for the prevention of infectious complications during operations on the organs of hearing and vision.

Contraindications

Norfloxacin is contraindicated: In case of liver failure. In terminal stages of renal failure. In case of hypersensitivity to Norfloxacin and drugs from its group. In case of deficiency of glucose-6-phosphate dehydrogenase in the body. During pregnancy and lactation. Children under 15 years of age.

Side effects

Side effects of the drug occur in approximately 3% of cases of its use. The digestive tract, central nervous system, and skin most often react.

From the digestive system Nausea, bitterness in the mouth, loss of appetite, cramps or abdominal pain, diarrhea, pseudomembranous colitis, dysbacteriosis may be bothersome. Sometimes liver function indicators (liver transaminases) transiently increase in the blood.

From the side of the central nervous system Side effects of Norfloxacin include headache, dizziness, drowsiness or insomnia, and occasionally convulsions, hallucinations and disorientation. Elderly patients while taking Norfloxacin may complain of tinnitus, irritation, fatigue, depression, unreasonable fear or anxiety.

Skin manifestations may be in the form of rash, itching, urticaria, swelling, increased photosensitivity, malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis.

From other systems and organs The following reactions may occur:

Urinary system: impaired urination, bleeding from the urethra, excessive urination, glomerulonephritis, crystalluria, the appearance of protein in the urine, increased concentrations of creatinine and urea in the blood plasma. The cardiovascular system: arrhythmias, tachycardia, arterial hypotension, vasculitis. Musculoskeletal system: inflammation and ruptures of tendons, joint pain. Manifestations of allergies are possible in the form of angioedema, anaphylaxis, and respiratory failure. A blood test reveals an increase in the number of eosinophils, a decrease in hematocrit and the number of leukocytes, agranulocytosis, and hemolytic anemia.

Treatment with Norfloxacin

How to use Norfloxacin?

Before prescribing the drug, it is advisable to determine whether the flora that caused the disease is sensitive to it.

The tablet is swallowed whole with a small amount of water, two hours before meals, antacids, drugs containing iron, zinc, magnesium, calcium.

The drug is used with caution in patients with impaired liver and kidney function, in patients with epilepsy, and cerebral atherosclerosis. The drug is immediately discontinued if pain in the tendons, allergic reactions, or signs of bronchospasm occur. In this case, you must immediately consult a doctor.

When treating with Norfloxacin, in order to avoid the formation of kidney and bladder stones, it is necessary to consume large amounts of fluid.

Drops must be warmed to body temperature before instillation into the eyes and ears.

Before instilling the medicinal solution into the ear, the external auditory canal is cleared of pus. When installing drops, the patient should tilt his head or lie on his side. After instillation, the head should be kept in this position for about two minutes. Then close the ear canal with a cotton wool turunda.

After instilling drops into the eyes, you should refrain from driving and other activities that require concentration for 30 minutes. Due to the possibility of photophobia, it is necessary to wear sunglasses and avoid bright light during treatment with Norfloxacin.

Dosage A single dose of the drug when taken orally is usually 1-2 tablets (400-800 mg) with a dosage frequency of 1-2 times a day. The maximum daily dose is 1.5 g.

For uncomplicated infections of the urinary system, the course of administration is about 3 days, for complicated ones - about 7-10 days. For chronic processes, the course can be increased to 3 months.

The exact dose and duration of the course are prescribed by the doctor individually for each patient.

In case of overdose, it is necessary to urgently rinse the stomach with a tube or by inducing vomiting, then symptomatic treatment should be prescribed.

In the form of drops, Norfloxacin is most often prescribed in combination with systemic antimicrobial therapy.

1-2 drops of the drug are instilled into the eyes in accordance with the doctor’s prescription:

for severe acute infections - every 15-30 minutes during the day; for moderate infections - up to six times a day; for trachoma - 2 drops 2-4 times a day for 1-2 months. 2-5 drops of the drug are instilled into the ear up to 3 times a day.

After the symptoms of the disease disappear, treatment is continued for two days.

Norfloxacin for children

Norfloxacin is contraindicated in children and adolescents under 15 years of age. For adolescents over 15 years of age, the drug is prescribed in the same way as for adults.

Use during pregnancy and lactation

The effect of Norfloxacin on the fetus has not been studied enough. Experimental studies have revealed that the drug causes disruption of joint development. Therefore, prescribing the drug during pregnancy is possible only for health reasons.

Norfloxacin for cystitis

In the treatment of cystitis, Norfloxacin is very effective: it quickly and effectively affects the microflora characteristic of most urinary tract infections, suppressing its growth. It also acts bactericidal against one of the most antibiotic-resistant bacteria - Pseudomonas aeruginosa, which can also be the causative agent of cystitis.

The dose of Norfloxacin and the duration of the course for the treatment of cystitis are determined by the doctor.

More about cystitis

Drug interactions

Norfloxacin:

Increases the concentration in the blood of Theophylline. When administered simultaneously with cyclosporines, increases the concentration of creatinine in the blood serum. Enhances the anticoagulant (anticoagulant) effect of Warfarin. May cause severe hypotension when prescribed simultaneously with antihypertensive drugs. Reduces the effect of drugs of the nitrofuran group. Slows down the period of elimination of caffeine from the body. Antacids (Almagel, Gastal), as well as drugs that contain calcium, zinc, and iron salts, reduce the absorption of Norfloxacin. Therefore, the interval between taking Norfloxacin and antacids should be at least 2 hours.

When prescribing Norfloxacin simultaneously with hypnotics of the barbiturate group, as well as with anesthetics, it is necessary to monitor blood pressure, pulse rate, and electrocardiogram parameters.

When using the drug together with Theophylline and non-steroidal anti-inflammatory drugs, the risk of convulsions and epileptiform seizures increases.

Norfloxacin analogs

Trade names of Norfloxacin:

Nolicin; Loxon; Norbactin; Normax; Norilet; Sophasin; Spectrama; Negaflox, etc.

Dosage form: The tablets are blue, round, biconvex, film-coated.

Before taking this medicine, read the entire leaflet carefully:

Do not throw away this leaflet. You may need to re-read it.

If you have any questions, ask your doctor or pharmacist.

This medicine must be prescribed to you by your doctor. Do not pass it on to others. It can harm them, even if their symptoms are the same as yours.

If any of the side effects become serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.

What is Norfloxacin and what is it used for: Each tablet of Norfloxacin contains the active substance: 200 mg or 400 mg of norfloxacin and excipients: dibasic calcium phosphate, corn starch, lactose monohydrate, gelatin, talc, magnesium stearate, colloidal anhydrous silicon dioxide, sodium starch glycolate, propylene glycol, brilliant blue sancoate (hydroxypropyl methylcellulose, titanium dioxide, talc, polyethylene glycol 400), brilliant blue (E 133). This drug belongs to the group of quinolones, antimicrobial agents for systemic use. Suppresses the growth of microorganisms that cause infections.

Norfloxacin is used in the following cases: indicated for the treatment of infections caused by organisms sensitive to it.

Urinary tract infections:

uncomplicated urinary tract infections (including cystitis);

complicated urinary tract infections.

Sexually transmitted diseases:

uncomplicated urethral and cervical gonorrhea caused by Neisseria gonorrhea;

prostatitis.

Before starting treatment, it is necessary to determine the sensitivity of microorganisms to norfloxacin. Treatment with norfloxacin may be started before test results are available. In this case, before starting therapy, it is necessary to select material for laboratory diagnostics in order to be able to change treatment if the infectious agents are not sensitive to norfloxacin. To reduce the possibility of development of bacterial resistance and reduced effectiveness, norfloxacin should be used only to treat infections caused by pathogens that are sensitive to it.

Do not take Norfloxacin if:

hypersensitivity to norfloxacin, other quinolones or excipients of this drug;

liver failure;

end-stage chronic renal failure;

pregnancy and lactation;

childhood and adolescence (up to 18 years);

lactase deficiency, lactose intolerance, glucose-galactose malabsorption;

a history of tendonitis or tendon ruptures associated with treatment with quinolone derivatives.

When prescribing Norfloxacin, be sure to inform your doctor about taking any of the following medications; it is necessary to take into account their interaction when taken together:

Medicines with an established risk factor for prolongation of the QT interval on the ECG (class IA and III antiarrhythmic drugs, antidepressants, macrolides, antipsychotics). Risk of developing arrhythmias and prolongation of the QT interval on the ECG. ECG monitoring.

Nitrofurantoin. The drugs are antagonists; joint use is not recommended.

Probenecid. Reduces the excretion of norfloxacin by the kidneys, but does not affect its concentration in the blood.

Cyclosporine. It is possible to increase the concentration of cyclosporine in the blood serum. It is recommended to monitor the concentration of cyclosporine in the blood serum and, if necessary, dose adjustment.

Warfarin and its derivatives (phenprocoumon, acenocoumarol). Potentiation of the action of anticoagulants is possible. Laboratory monitoring of blood clotting parameters is recommended.

Hormonal contraceptives. The contraceptive effect may be reduced when taking norfloxacin. Additional methods of contraception are recommended during treatment.

Fenbufen. Concomitant use may provoke an epileptic attack; combination should be avoided.

Clozapine, ropinirole. When taking norfloxacin, a dose adjustment of clozapine or ropinirole may be necessary in patients already taking these drugs.

Glibenclamide. A sharp decrease in blood sugar is possible. Monitoring blood sugar levels is recommended.

Didanosine. Drugs may prevent one another from being absorbed. Didanosine is taken two hours after taking norfloxacin.

Nonsteroidal anti-inflammatory drugs (NSAIDs). The combination is used with caution; stimulation of the central nervous system with convulsive attacks is possible.

Antacids containing aluminum or magnesium hydroxide; preparations or products containing calcium salts (including milk salts), iron and zinc. Norfloxacin absorption is reduced. Norfloxacin should be taken 1-2 hours before or at least 4 hours after taking these drugs.

Theophylline. It is possible to increase the concentration of theophylline in the blood and develop side effects. It is recommended to monitor the concentration of theophylline in the blood and, if necessary, adjust the dose.

Antihypertensive drugs. A sharp decrease in blood pressure is possible. When taken simultaneously with drugs that lower the convulsive threshold of the brain (theophylline), epileptiform seizures occur.

Nitrofurans. Norfloxacin reduces the effect of nitrofurans.

Corticosteroid hormones. Increased risk of tendon rupture, especially in older patients.

Use of Norfloxacin during pregnancy and lactation: Contraindicated.

Impact on the ability to drive vehicles and operate machinery: The ability to drive a car and use other machinery may be reduced due to the effect of norfloxacin on reaction speed.

Directions for use and doses

Dosing for patients with normal renal function.

Uncomplicated urinary tract infections (cystitis): 400 mg 2 times a day, for 3-10 days.

Complicated urinary tract infections: 400 mg 2 times a day, for 10-21 days.

Sexually transmitted diseases: 800 mg once.

Prostatitis (acute, chronic): 400 mg 2 times a day, for 28 days.

Dosing in patients with renal impairment:

In patients with a creatinine clearance of 30 ml/min/1.73 m 3 or less, the recommended dose is 400 mg once daily for the duration of treatment indicated above.

With a known level of creatinine clearance, the following formula is used to calculate the dose (taking into account the gender, weight and age of the patient):

Men =

Women =(0.85) x (higher value)

Elderly patients. With normal renal function, no dose adjustment is required.

Possible side effects:

From the cardiovascular system: prolongation of the QT interval on the ECG, ventricular arrhythmia.

From the gastrointestinal tract: vomiting, heartburn, pancreatitis.

From the nervous system: dizziness, hallucinations, mood changes, sensory disturbances, insomnia, depression, anxiety, irritability, euphoria, disorientation, anxiety, polyneuropathy, including Guillain-Barré syndrome, seizures, mental disorders, tremor, twitching of large muscles.

From the hematopoietic system: decrease in the number of neutrophils, platelets in the blood, anemia.

From the urinary system: inflammation of the kidney.

From the musculoskeletal system and connective tissue: joint pain, inflammation of ligaments/tendons, tendon ruptures, muscle pain, arthritis, very rarely - inflammation of the Achilles tendon and rupture.

From the skin and subcutaneous tissue: skin itching, swelling, rashes, minor hemorrhages, hemorrhagic bullae and papules with crust formation as a manifestation of vascular damage.

From the immune system: angioedema; in isolated cases - exfoliative dermatitis, Stevenson-Johnson syndrome, Lyell's syndrome, exudative polymorphic erythema, photosensitivity.

Changes in laboratory parameters: increased levels of glutomat-oxaloacetate transaminase,

glutamate-pyruvate transaminase, alkaline phosphatase in the blood.

Others: vaginal candidiasis, increased lacrimation, ringing in the ears, hearing loss, shortness of breath, taste disorders.

If you take a higher dose of Norfloxacin than your doctor recommends: If the number of tablets you take per day exceeds the number recommended by your doctor, or your child swallows tablets, consult a doctor or call an ambulance! Stop taking the medicine! An overdose may include dizziness, headache, fatigue, convulsions, hallucinations, confusion, abdominal discomfort, impaired kidney and liver function, and the presence of crystals and blood in the urine. As first aid, it is recommended to rinse the stomach and take antacids.

Precautions and special instructions when taking Norfloxacin:

Hypersensitivity. After taking a single dose of the drug, hypersensitivity reactions are possible, including anaphylactic and anaphylactoid reactions, life-threatening conditions. Stop taking the medicine immediately, inform your doctor immediately or call an ambulance!

Pseudomembranous colitis. If you suspect pseudomembranous colitis (loose stools for a long time, possibly with blood or mucus in it), you should immediately stop taking it and immediately consult a doctor for appropriate treatment! You should not use medications that inhibit intestinal motility.

Central nervous system. It is known that quinolones can lower the seizure threshold and initiate seizures. Use with caution in patients with central nervous system diseases that provoke seizures. Cases of polyneuropathy (pain, burning, anxiety, tinnitus, muscle weakness, sensitivity disorders, including tactile, pain, temperature, vibration and muscle-articular) have been reported. If these phenomena occur, stop taking the drug! Inform your doctor immediately!

The cardiovascular system. Since the use of norfloxacin is associated with cases of prolongation of the QT interval on the ECG, caution must be exercised when treating patients at risk of developing arrhythmia: congenital prolongation of the QT interval; simultaneous use of class IA and III antiarrhythmic drugs, antidepressants, macrolides, antipsychotics; electrolyte disturbances; women and elderly patients are more sensitive; heart diseases.

Musculoskeletal system. Norfloxacin should not be used in patients with tendon diseases or disorders due to previous use of quinolones. If it is necessary to treat severe infectious diseases in such patients, a microbiological study and assessment of the risk-benefit ratio are carried out. Inflammation or tendon rupture may occur, especially in elderly patients or those concomitantly taking corticosteroids. If there are any signs of this disease (swelling, inflammation), stop taking the drug and immobilize the affected limb. Use with caution in patients with myasthenia gravis.

Photosensitivity. Patients taking norfloxacin should avoid direct exposure to sunlight and UV radiation.

Syphilis. Norfloxacin is not indicated for the treatment of syphilis. Antimicrobial drugs used in high doses for a short period of time to treat gonorrhea may mask or delay the onset of symptoms of developing syphilis. All patients with gonorrhea should undergo a serological test for syphilis at the time of diagnosis, and again (3 months later) after the prescription of norfloxacin.

Surgical reactions. Warn your doctor about taking norfloxacin: monitoring the state of the blood coagulation system is recommended (an increase in the prothrombin index is possible).

Glucose-6-phosphate dehydrogenase deficiency. The development of hemolytic reactions is possible. The drug is not prescribed to such patients, except in cases where the potential benefit outweighs the possible risk.

Excipients. Do not take in cases of congenital galactose intolerance and Lapp lactase deficiency or malabsorption of glucose and galactose (contains lactose).

General information. Use with caution for atherosclerosis of cerebral vessels, cerebrovascular accidents, epilepsy and convulsive syndrome, impaired renal and liver function.

Storage conditions:

Store in a place protected from moisture and light, at a temperature not exceeding 25°C. Keep out of the reach of children.

Best before date:

3 years. Do not use the medicine after the expiration date.

Vacation conditions:

By doctor's prescription.

Package:

10 or 20 tablets in polymer jars. 1 can along with an insert in a pack.

10 tablets in a blister pack. 1 or 2 blister packs in a pack.

Manufacturer information:

Produced by: “Belarusian-Dutch joint venture limited liability company “Farmland” (JV LLC “Farmland”), Republic of Belarus, Nesvizh, st. Leninskaya, 124 – 3.

What is Norfloxaqin and what is it used for

Each tablet of Norfloxacin contains the active substance: 200 mg or 400 mg of norfloxacin and excipients: dibasic calcium phosphate, corn starch, lactose monohydrate, gelatin, talc, magnesium stearate, colloidal anhydrous silicon dioxide, sodium starch glycolate, propylene glycol, brilliant blue sancoate (hydroxypropyl methylcellulose, titanium dioxide, talc, polyethylene glycol 400), brilliant blue (E 133). This drug belongs to the group of quinolones, antimicrobial agents for systemic use. Suppresses the growth of microorganisms that cause infections.

Norfloxacin pis used in the following cases:

Norfloxacin is indicated for the treatment of infections caused by microorganisms sensitive to it:

Uncomplicated and complicated, acute and chronic cystitis and pyelitis; chronic prostatitis; uncomplicated pyelonephritis;

Due to the risk of serious adverse reactions, fluoroquinolones, including norfloxacin, should be used as a reserve drug in patients with uncomplicated urinary tract infections (including cystitis) and only in cases where no alternative treatment options are available.

Urinary tract infections associated with surgical/urological procedures or nephrolithiasis.

Treatment is carried out in accordance with the doctor's prescription. Before starting treatment, it is recommended to study the sensitivity of the bacterial flora to the prescribed antibacterial agent.

Do not take Norfloxacin if:

Hypersensitivity to norfloxacin and other quinolone derivatives, as well as in case of hypersensitivity to any of the other ingredients included in the drug; a history of tendonitis or tendon ruptures associated with treatment with quinolone derivatives; simultaneous use of norfloxacin and tizanidine; pregnancy and lactation; childhood and adolescence (up to 18 years);

When prescribing Norfloxacin, I will definitely inform youpleasedoctor about taking any ofof the drugs listed below, it is necessary to consider their mutualEffects when taken together:

Medicines with an established risk factor for interval prolongationQT on an ECG (with antiarrhythmic drugsI.A. and class III, antidepressants, macrolides, antipsychotics). Risk of developing arrhythmias and prolongation of the QT interval on the ECG. ECG monitoring.

Nitrofurans. The drugs are antagonists; joint use is not recommended. Norfloxacin reduces the effect of nitrofurans.

Probenecid. Reduces the excretion of norfloxacin by the kidneys, but does not affect its concentration in the blood.

Cyclosporine. It is possible to increase the concentration of cyclosporine in the blood serum. It is recommended to monitor the concentration of cyclosporine in the blood serum and, if necessary, dose adjustment.

Warfarin and its derivatives (phenprocoumon, acenocoumarol). Potentiation of the action of anticoagulants is possible. Laboratory monitoring of blood clotting parameters is recommended. Hormonal contraceptives. The contraceptive effect may be reduced when taking norfloxacin. Additional methods of contraception are recommended during treatment.

Fenbufen. Concomitant use may provoke an epileptic attack; combination should be avoided.

Clozapine,ropinirole. When taking norfloxacin, a dose adjustment of clozapine or ropinirole may be necessary in patients already taking these drugs.

Tizanidine. Concomitant use with norfloxacin is contraindicated.

Glibenclamide. A sharp decrease in blood sugar is possible. Monitoring blood sugar levels is recommended.

Didanosine. Drugs may prevent one another from being absorbed. Didanosine is taken two hours after taking norfloxacin.

Nonsteroidal anti-inflammatory drugs (NSAIDs). The combination is used with caution; stimulation of the central nervous system with convulsive attacks is possible.

Antacids containing aluminum or magnesium hydroxide, sucralbveil; preparations or products containing calcium salts (including milk salts), iron and zinc. Norfloxacin absorption is reduced. Norfloxacin should be taken 1-2 hours before or at least 4 hours after taking these drugs.

Theophylline. It is possible to increase the concentration of theophylline in the blood and develop side effects. It is recommended to monitor the concentration of theophylline in the blood and, if necessary, adjust the dose.

Antihypertensive drugs. A sharp decrease in blood pressure is possible.

When taken simultaneously with drugs that lower the convulsive threshold of the brain (theophylline), epileptiform seizures occur.

Corticosteroid hormones. Increased risk of tendon rupture, especially in older patients.

The use of Norfloxacin for painduring pregnancy and lactation

Contraindicated.

Impact on driving abilityport and mechanism control

Norfloxacin may affect the reaction rate and impair the ability to drive vehicles and use machinery, especially at the beginning of treatment, when the dose is increased, or in combination with alcohol. During treatment with norfloxacin, you should refrain from driving vehicles or operating other mechanisms.

Directions for use and doses

Dosing for patients with normalfunctionkidney.

Uncomplicated urinary tract infections (cystitis): 400 mg 2 times a day, for 3-10 days. Complicated urinary tract infections: 400 mg 2 times a day, for 10-21 days.

Prostatitis (chronic): 400 mg 2 times a day, for 28 days.

Dosage in patients with infection associated with surgical (urological) procedures or urolithiasis: The usual dose is 400 mg 2-3 times daily. The daily dose and duration of treatment depend on the severity and frequency of recurrence of the infection.

Dosing in patients with renal impairment.

In patients with a creatinine clearance of 30 mL/min/1.73 m3 or less, the recommended dose is 400 mg once daily for the treatment duration indicated above.

With a known level of creatinine clearance, the following formula is used to calculate the dose (taking into account the gender, weight and age of the patient):

(weight, kg) × (140 - age)

Men =

72 × serum creatinine (mg/100)

Women = (0.85) × (higher magnitude).

Patients with impaired liver function. Use with caution for liver diseases.

Elderly patients. With normal renal function, no dose adjustment is required.

Children. Contraindicated for use in children and adolescents under 18 years of age.

If you missed the next one1st dose of the drug

You must take a single dose the next time you take the medicine. Do not take a double dose to make up for a missed dose.

Possible side effects

If any adverse reaction occurs (whether listed or not listed in the leaflet) during treatment with Norfloxacin or shortly after its discontinuation, you should consult a doctor.

Disorders of the cardiovascular system: tachycardia, myocardial infarction, chest pain, very rarely when taking norfloxacin, prolongation of the QT interval and ventricular arrhythmia (including torsade de pointes) may occur. When norfloxacin is used concomitantly with drugs with an established risk factor for prolongation of the QT interval, as well as when prescribed to patients with known risk factors for prolongation of the QT interval, the possibility of prolongation of the QT interval increases sharply.

Gastrointestinal disorders: vomiting, heartburn, pancreatitis, nausea, anal itching, constipation, flatulence, ulcers on the oral mucosa, dry mouth, dyspepsia, abdominal pain, diarrhea, anorexia, anorectal pain, pseudomembranous colitis.

Nervous system disorders: dizziness, hallucinations, mood changes, paresthesia, insomnia, depression, anxiety, irritability, euphoria, disorientation, anxiety, polyneuropathy, including Guillain-Barré syndrome, epileptiform seizures, hypoesthesia, mental disorders, including psychotic reactions , tremor, myoclonus, asthenia, sleep disturbance, ataxia.

Hematopoietic system disorders: neutropenia, hemolytic anemia, thrombocytopenia, decreased hemoglobin concentration, hematocrit, eosinophilia, agranulocytosis, increased prothrombin time.

Disorders of the urinary system: interstitial nephritis, proteinuria, glycosuria, renal colic, crystalluria, renal failure, increased concentration of urea, creatinine in the blood.

Musculoskeletal and connective tissue disorders: arthralgia, tendonitis, tendovaginitis, tendon ruptures, myalgia, arthritis, muscle spasms, increased myasthenia gravis, rhabdomyolysis. Very rarely - inflammation of the Achilles tendon, which can lead to its rupture.

Skin and subcutaneous tissue disorders: skin itching, swelling, exanthema, petechiae, erythema, hemorrhagic bullae and papules with crust formation as a manifestation of vascular involvement (vasculitis), hyperhidrosis,

Immune system disorders: angioedema; in isolated cases - exfoliative dermatitis, Stevenson-Johnson syndrome, Lyell's syndrome, exudative subdimorphic erythema, photosensitivity, hypersensitivity reactions (including anaphylactic/anaphylactoid reactions, dyspnea, urticaria, erythema, rash, DRESS syndrome).

Disorders of the reproductive system and mammary glands: vaginal candidiasis, dysmenorrhea.

Visual disturbances: diplopia, increased lacrimation.

Disorders of the hearing organ and labyrinth: tinnitus, hearing loss.

Disorders of the respiratory system, chest and mediastinal organs: shortness of breath.

Liver and biliary tract disorders: hepatitis, jaundice, liver failure, bitter taste in the mouth.

General disorders and reactions at the injection site: increased temperature, fever, chills, increased levels of glutamate-oxaloacetate transaminase, glutamate-pyruvate transaminase and serum alkaline phosphatase, increased LDH, increased creatine phosphokinase.

If you have taken a dose of Norfloxacinmore than the doctor recommended

If the number of tablets per day you take exceeds the number recommended by your doctor, or your child swallows tablets, consult a doctor or call an ambulance! Stop taking the medicine! An overdose may include dizziness, headache, fatigue, convulsions, hallucinations, confusion, abdominal discomfort, impaired kidney and liver function, and the presence of crystals and blood in the urine. As first aid, it is recommended to rinse the stomach and take antacids.

Precautions and special instructions when taking Norfloxacin

Norfloxacin belongs to a class of antibiotics called fluoroquinolones, which can cause serious bone-related side effects.muscular system or nervous systemstems. Some of them may occur insametime in one patient and lead to severe irreversible changes, and even death.If yThe patient is observed one of the followingif serious side effects occur, you must stopuse the drug and adjustSee your doctor: pain, swelling, inflammation or bruising in the area of ​​the jointwalking, including the backpart of the ankle (Achilles tendon), shoulder, arm, or in the monthtach other tendons; pain,onepain, fever, weakness or tingling in the hands, arms, legs orand feet; convulsions, tremor, gallinglucinations, “nightmare” dreams, dizziness, strongheadaches with or without headachesloss of vision, increased anxiety, suicidal thoughtsor actions, confusionniya, depression.

Hypersensitivity. After taking a single dose of the drug, hypersensitivity reactions are possible, including anaphylactic and anaphylactoid reactions, life-threatening conditions. Stop taking the medicine immediately, inform your doctor immediately or call an ambulance!

Pseudomembranous colitis. If pseudomembranous colitis is suspected (loose stools for a long time, possibly With admixture of blood or mucus in it) you should immediately stop taking it and urgently consult a doctor for appropriate treatment! You should not use medications that inhibit intestinal motility.

Central nervous system. It is known that quinolones can lower the seizure threshold and initiate seizures. Use with caution in patients with central nervous system diseases that provoke seizures. Cases of polyneuropathy (pain, burning, anxiety, tinnitus, muscle weakness, sensitivity disorders, including tactile, pain, temperature, vibration and muscle-articular) have been reported. If these phenomena occur, stop taking the drug! Inform your doctor immediately!

Cardiovascularsystem. Since the use of norfloxacin is associated with cases of prolongation of the QT interval on the ECG, caution must be exercised when treating patients at risk of developing arrhythmia: congenital prolongation of the QT interval; simultaneous use of class IA and III antiarrhythmic drugs, antidepressants, macrolides, antipsychotics; electrolyte disturbances; women and elderly patients (more sensitive); heart diseases.

Musculoskeletal system. Norfloxacin should not be taken by patients with tendon diseases or disorders due to previous use of quinolones. If it is necessary to treat severe infectious diseases in such patients, a microbiological study and assessment of the risk-benefit ratio are carried out. Tendon inflammation or rupture may occur, especially in elderly patients or those concomitantly taking corticosteroids. If there are any signs of this disease (swelling, inflammation), stop taking the drug and immobilize the affected limb. Norfloxacin may increase the symptoms of myasthenia gravis and lead to life-threatening weakness of the respiratory muscles. When per If there are signs of deterioration, it is recommended to immediately consult a doctor. It is recommended to avoid the use of norfloxacin if there is a history of myasthenia gravis.

Compound

Active substance: norfloxacin 400 mg.

Excipients: colloidal silicon dioxide (Aerosil), magnesium stearate, microcrystalline cellulose, croscarmellose sodium, crospovidone.

Indications for use Norfloxacin

Infectious and inflammatory diseases caused by microorganisms sensitive to norfloxacin:

• urinary tract infections (except acute and chronic complicated pyelonephritis),
• chronic bacterial prostatitis,
• uncomplicated gonorrhea,
• salmonellosis,
• shigellosis.

Prevention of traveler's diarrhea, prevention of sepsis in patients with neutropenia.

Contraindications to the use of Norfloxacin

• Hypersensitivity;
• tendonitis, tendon rupture caused by taking fluoroquinolones (including in history);
• pregnancy,
• lactation period,
• childhood,
• deficiency of glucose-6-phosphate dehydrogenase.

Inside.

For urinary tract infections- 400 mg 2 times a day for 7-10 days; for uncomplicated cystitis - 3-7 days; for chronic recurrent urinary tract infections - up to 12 weeks.

For acute bacterial gastroenteritis- 5 days.

For acute gonococcal urethritis, pharyngitis, proctitis, cervicitis- once 800 mg.

For typhoid fever- 400 mg 3 times a day for 14 days.

For the prevention of sepsis- 400 mg 2 times a day.

For the prevention of bacterial gastroenteritis- 400 mg per day.

To prevent traveler's diarrhea- 400 mg per day 1 day before departure and during the entire travel period (no more than 21 days).

To prevent recurrence of urinary tract infections- 200 mg per day.

In patients with impaired renal function when CC is more than 20 ml/min, no adjustment of the dosage regimen is required. When CC is below 20 ml/min (or serum creatinine concentration is more than 5 mg/100 ml) and patients on hemodialysis are prescribed 1/2 of the therapeutic dose 2 times a day or a full dose 1 time a day.

Use of Norfloxacin during pregnancy and lactation

The drug is contraindicated for use by pregnant women and women during breastfeeding. When used during lactation, breastfeeding should be discontinued.

pharmachologic effect

Norfloxacin is an antibacterial agent. Used for the treatment of infectious and inflammatory diseases such as pyelonephritis, cystitis, urethritis, gonorrhea, prostatitis, intestinal infections, ophthalmic and ENT infections.

Side effects Norfloxacin

From the central nervous system (CNS): dizziness, headache, tingling in fingers, drowsiness, anxiety, depression, insomnia, sleep disturbance.

From the digestive system: nausea, abdominal pain, anorexia, diarrhea, pain in the rectum or anus, constipation, dyspepsia, flatulence, vomiting, dry oral mucosa, heartburn, loose stools, bitter taste in the mouth, ulceration of the oral mucosa, itching of the anus .

From the hematopoietic organs: leukopenia, thrombocytopenia, eosinophilia, neutropenia.

From the skin: itching, rash, erythema, urticaria.

From the senses: blurred visual perception.

From the musculoskeletal system: bursitis, swelling of the hands and feet.

From the cardiovascular system (CVS): myocardial infarction, palpitations.

From the urinary system: renal colic.

Laboratory indicators: increased activity of AST, ALT, alkaline phosphatase, LDH, proteinuria, decreased hematocrit and Hb, increased urea concentration in the blood, hypercreatininemia, glucosuria.

Others: hyperhidrosis, asthenia, back pain, fever, chills, chest pain, dysmenorrhea, edema, allergic reactions.

special instructions

Use the drug with caution for the following diseases:
Epilepsy, seizure syndrome, renal/liver failure, myasthenia gravis.
During the treatment period, patients should receive a sufficient amount of fluid (under the control of diuresis).
During the period of therapy, an increase in the prothrombin index is possible (during surgical interventions, the state of the blood coagulation system should be monitored).
During treatment, exposure to direct sunlight should be avoided.
Norfloxacin, like other fluoroquinolones, can cause tendinitis and tendon rupture. Risk factors: age over 60 years, taking glucocorticosteroids, kidney, heart or lung transplantation, increased physical activity, chronic renal failure, history of tendon damage (including rheumatoid arthritis). These phenomena may occur several months after stopping the drug. At the first sign of tendonitis or tendon rupture, you should stop taking norfloxacin and consult a doctor.
Norfloxacin may lower the seizure threshold and cause seizures; fluoroquinolones can also stimulate the central nervous system, causing tremors, toxic psychosis, anxiety, confusion and hallucinations; increased intracranial pressure.
Norfloxacin can lead to the development of pseudomembranous colitis caused by Clostridium difficile. In this case, it is necessary to discontinue the drug and prescribe appropriate treatment (oral vancomycin or metronidazole).
Not effective against syphilis.
Norfloxacin can cause peripheral neuropathy (paresthesia, hypoesthesia, dysesthesia, muscle weakness). At the first signs of neuropathy (pain, tingling, numbness or weakness in the limbs, disturbance of other types of sensitivity), the drug should be discontinued in order to avoid irreversible changes.
To avoid the formation of norfloxacin crystals in the kidneys, do not exceed recommended doses; It is necessary to take the tablets with sufficient liquid.

Overdose

In case of overdose, the stomach must be cleared by inducing vomiting or by gastric lavage with a tube, and the patient should be carefully examined and given symptomatic and supportive treatment. It is necessary to monitor water-salt metabolism, the patient should receive plenty of fluid to avoid the formation of stones in the urinary tract.

Drug interactions

With simultaneous use of norfloxacin with warfarin, the anticoagulant effect of the latter is enhanced.

With simultaneous use of norfloxacin with cyclosporine, an increase in the concentration of the latter in the blood plasma is observed.

When taking norfloxacin simultaneously and antacids or drugs containing iron, zinc, magnesium, calcium or sucralfate, the absorption of norfloxacin is reduced due to the formation of complexons with metal ions (the interval between their administration should be at least 4 hours).

When administered concomitantly, norfloxacin reduces the clearance of theophylline by 25%; therefore, the dose of theophylline should be reduced when used concomitantly.

The simultaneous administration of norfloxacin with drugs that have the potential to lower blood pressure can cause a sharp decrease in blood pressure. In this regard, in such cases, as well as with the simultaneous administration of barbiturates and anesthetics, heart rate, blood pressure, and ECG indicators should be monitored. Concomitant use with drugs that lower the epileptic threshold can lead to the development of epileptiform seizures.

Reduces the effect of nitrofurans.

Storage conditions

Store the drug at a temperature not exceeding 25°C out of the reach of children.

Shelf life - 3 years.

Recipe (international)

Rp.: Tab. Norfloxacini 0.4 N 20

D.S. 1 table each 2 times a day. Duration of treatment - 7-14 days; If necessary, longer treatment is carried out.

pharmachologic effect

As indicated in the instructions, Norfloxacin has antimicrobial and bactericidal effects, the mechanism of which is based on the drug’s ability to disrupt the process of DNA supercoiling of bacterial microorganisms and inhibit the bacterial enzyme DNA gyrase.

An antimicrobial drug from the quinolone group, a uroantiseptic (a drug that disinfects the urinary tract), which has a wide spectrum of action. Acts bactericidal (destroys bacteria). Norfloxacin is active against most gram-negative microorganisms: Es-cherichiacoli, Salmonellaspp., Shigellaspp., Proteusspp., Morganellamorganii, Klebsiellaspp., including Klebsiellapneumoniae; Enterobacterspp., Serratiaspp., Citrobacterspp., Yersiniaspp., Providencia, Haemophilusinfluenzae, Pseudomonasaeruginosa; as well as against microorganisms producing beta-lactamases (enzymes that destroy penicillins).

Mode of application

For adults: Before prescribing a drug to a patient, it is advisable to determine the sensitivity to it of the microflora that caused the disease in this patient. The usual dosage is 0.4 g 2 times a day. The maximum daily dose is 1.5 g. Duration of treatment is 7-14 days; If necessary, longer treatment is carried out.

For patients with impaired renal function with creatinine clearance (the rate of blood purification from the final product of nitrogen metabolism - creatinine) of more than 20 ml/min, norfloxacin is prescribed in the usual dose. When creatinine clearance is below 20 ml/min (or at a serum creatinine level of more than 5 mg/100 ml), half the usual dose of norfloxacin is prescribed 2 times a day or a full dose 1 time a day. Patients on hemodialysis (a blood purification method) are prescribed half the usual dose of the drug.

The simultaneous use of norfloxacin and antacids (reducing gastric acidity) reduces the intensity of absorption of norfloxacin. In this regard, norfloxacin should be prescribed 1-2 hours before or no less than 4 hours after taking these medications.

Indications

The use of Norfloxacin is indicated in the treatment of infectious diseases caused by pathogens that are sensitive to the drug. Such diseases include:

gastrointestinal infections (shigellosis, salmonellosis);
acute and chronic infections
urinary tract (cystitis, pyelonephritis, urethritis);
uncomplicated gonorrhea;
genital infections (endometritis, prostatitis, cervicitis).
Reviews of Norfloxacin indicate that the drug is also effective in preventing infectious diseases in patients with granulocytopenia.

Forms of the drug for topical use are used in the treatment of:
otitis media, including external, acute and chronic otitis media;
infectious eye diseases (keratitis, conjunctivitis, keratoconjunctivitis, blepharoconjunctivitis, blepharitis and corneal ulcer); dacryocystitis;
acute inflammation of the meibomian glands.

In addition, as evidenced by reviews of Norfloxacin, the drug is an effective prophylactic agent that reduces the risk of infectious complications before and after surgery, removal of foreign bodies from the cornea or conjunctiva, as well as after chemical damage to the eyes. For the same purpose, Norfloxacin is used in surgical interventions on the hearing organs.

Contraindications

Norfloxacin is an antibiotic of the quinolone group of drugs, therefore its use is contraindicated in patients with hypersensitivity to any other drugs of this group and in particular to norfloxacin. Also, the drug is not used to treat children under 15 years of age, during pregnancy and lactation, or with glucose-6-phosphate dehydrogenase deficiency.

The use of Norfloxacin should be limited in dose size and frequency of administration in patients with severe impairment of liver and kidney function, epilepsy or other type of convulsive syndrome.

Side effects

According to the instructions, Norfloxacin can have a systemic effect on the body, which manifests itself in the form of the following side effects:
heart rhythm disturbances, tachycardia, decreased blood pressure, leukopenia, eosinophilia, vasculitis, decreased hematocrit; bitterness in the mouth, loss of appetite, nausea, vomiting, diarrhea, abdominal pain, increased activity of liver transaminases, with long-term use - pseudomembrane colitis; dizziness, headache, insomnia, fainting, hallucinations; dysuria, polyuria, glomerulonephritis, crystalluria, hypercreatininemia, albuminuria, urethral bleeding; arthralgia, tendinitis, tendon ruptures; swelling, skin itching, urticaria, Stevens-Johnson syndrome.