Cinnarizine: instructions for use and what it is needed for, price, reviews, analogues. Practical use of Cinnarizine in neurology: instructions and reviews

The drug Cinnarizine is prescribed to relieve pain symptoms and for treatment vascular disorders. The medicine is available only in tablet form. When taking it, it is important to know the exact dosage and duration of the course. We will tell you how to take Cinnarizine correctly, its properties, contraindications. You will find out what side effects it has.

Doctors prescribe Cinnarizine for the following disorders in cerebral circulation:

1. Relieving an attack of dizziness;
2. Against tinnitus;
3. For the treatment of headaches caused by vascular diseases;
4. For irritability and stress;
5. If a person has a bad memory;
6. As a prophylaxis for migraine;
7. Inability to concentrate on work.

The drug can also be taken for peripheral diseases:

• Raynaud's disease;
• With acrocyanosis;
• For the treatment of initial lameness;
• For varicose ulcers on the body;
• To relieve night cramps in the legs;
• If the extremities become cold;
• At the time of trophic disturbances;
• As symptomatic treatment vascular diseases.

Doctors advise taking Cinnarizine for diseases associated with imbalance:

1. Labyrinthine diseases;
2. Severe dizziness;
3. Attacks of nystagmus;
4. Nausea and vomiting;
5. Tinnitus;
6. As a prevention of diseases of the musculoskeletal system.

For each disease, a specific dosage of Cinnarizine is prescribed. The prescription must be written by the attending physician after a complete examination.

Contraindications for use

The medicine does not have many contraindications. Doctors prohibit taking the drug if you are allergic to any component in its composition. Also, if the patient experiences side effects during treatment, Cinnarizine therapy should be stopped immediately.

Interaction with other drugs

You need to know which medications can enhance or weaken the effect of Cinnarizine. When taken in parallel, the dosage must be adjusted so that the patient does not develop complications.

Doctors noted that CNS depressants with simultaneous administration may enhance sedative effect from Cinnarizin. It should also not be taken with alcohol. Tricyclic antidepressants should be prescribed with caution at the time of primary treatment.

You need to know that Cinnarizine masks skin reactivity. If the patient needs to undergo a skin test, then the doctor recommends stopping the medication 4 days before the diagnosis.

Be sure to tell your doctor what medications you are taking at the same time. Then the specialist will reduce the dosage or stop taking some pills.

Features of using the drug

The medicine Cinnarizine has some features when used, which every patient should know about. If you follow the doctor's advice, then the treatment will pass successfully and the drug will not cause side effects.

• Cinnarizine causes stomach irritation when long-term use. Doctors advise taking the pill only after meals. Then the negative effect on the stomach will decrease;
• If a patient has Parkinson's disease, he needs to take Cinnarizine only when absolutely necessary;
• At the beginning of treatment, Cinnarizine causes drowsiness, fatigue and weakness of the whole body. Therefore, doctors do not recommend taking alcohol or other relaxing pills. Otherwise, it will be difficult for the patient to work;
• Doctors advise against taking Cinnarizine for porphyria;
• You need to carefully set the dosage of the drug for people with liver and kidney disease;
• If the patient has glucose intolerance, Cinnarizine therapy is strictly prohibited. The drug is also dangerous in case of lactose deficiency in humans and glucose syndrome.

In order for the medicine to help cope with the disease and not harm the body, it is necessary to consult a doctor before taking it. After a careful diagnosis, the doctor will be able to adjust the dosage specifically for your disease.

Taking medication for pregnant women

Doctors categorically prohibit pregnant women from taking Cinnarizine at any stage. The composition of the drug can harm the health of the unborn baby. Also, mothers should refrain from therapy at the moment breastfeeding. Cinnarizine substances can enter the child’s body through milk and cause severe allergies. If a woman needs therapy, she should immediately stop breastfeeding.

Transport management

It must be remembered that Cinnarizine causes drowsiness and loss of concentration. This is why you should not drive during therapy. You should also not go to work that requires high attention and control of machinery.

Medicine dosage

For each type of disease there is an exact dosage of Cinnarizine. It must be remembered that the drug is suitable for the treatment of adults and adolescents over 12 years of age. Children are strictly prohibited from taking the medicine.

If the patient has problems with the blood circulation in the brain, then it is necessary to take one tablet 3 times a day. This dose is suitable for adults and adolescents over 12 years of age.

To treat peripheral circulatory diseases, take Cinnarizine 3 tablets 3 times a day. Doctors noted that the maximum dosage for an adult is no more than 9 tablets. It's 225 mg active substance. To relieve attacks of dizziness, it is necessary to gradually increase the dosage. This should be monitored by the attending physician.

For imbalances, you need to take one Cinnarizine tablet 2-3 times a day. If a person has a fear of transport and flying, you need to take a pill 30 minutes before the trip. When traveling long distances, take Cinnarizine every 6 hours.

The medicine must be taken after meals to avoid stomach irritation. Take the pill with a glass warm water. The course of treatment with the drug is long - 2-3 weeks. It depends on the complexity of the disease and individual indicators patient.

Drug overdose

If a patient takes a dose of Cinnarizine from 90 to 2200 mg, he may experience severe complications. An overdose is expressed by the following unpleasant symptoms:

1. The patient's drowsiness gradually turns into a mild coma;
2. It might start severe attack vomiting;
3. Doctors observed extrapyramidal symptoms in patients;
4. The occurrence of arterial hypotension;
5. If a child takes the pills, he may experience severe cramps.

Doctors noted that with a large overdose, cases were observed fatal outcome. However, if you immediately go to the hospital and undergo emergency therapy, then Cinnarizine will not harm the body.

Within 60 minutes after an overdose, the patient's stomach must be rinsed. The doctor will make an appointment activated carbon for additional cleaning. Therapy must take place in a hospital to avoid health complications.

Side effects of tablets

Cinnarizine has a number of side effects that can occur if the dosage is incorrect or if there is an individual intolerance to the drug. Here are the most common symptoms:

1. Severe drowsiness;
2. Stomach problems;
3. Headache attacks;
4. Feeling of dry mouth, feeling of thirst;
5. Manifestation of cholestatic jaundice;
6. Allergy to the components of the drug.

These side effects usually go away quickly if your doctor adjusts the dose. In the case when Cinnarizine is taken old man, in case of any complication, it is necessary to discontinue the drug. It is also worth highlighting other side effects that occur quite rarely.

If any symptom occurs, you should immediately inform your doctor. Then he will be able to stop Cinnarizine in time or reduce its dose. With constant health monitoring, the drug will not cause harm.

Pharmacological properties of tablets

The drug affects the contraction of cells in blood vessels and blocks calcium channels. At the same time, the medicine reduces the effect of vasoconstriction active substance. For example, the effect of norepinephrine and serotonin is reduced. Cinnarizine reduces vasoconstriction, but does not affect the patient's blood pressure. Also, the drug does not reduce the heart rate.

Treatment tablets improve blood microcirculation at the time of insufficiency. Long-term therapy will help reduce blood viscosity and significantly increase the elasticity of the membrane. Doctors noted that the effect of the drug can increase resistance in cells.

The medicine has a suppressive effect on the vestibular apparatus. This can lead to disorders in autonomic system. Cinnarizine copes well with attacks of dizziness and reduces their frequency.

Pharmacokinetics of the drug

The absorption process of Cinnarizine does not last long. The highest level of concentration in the blood occurs 2 hours after taking the tablet. The substance then combines with proteins in the plasma. The concentration when applied is 90 percent.

The removal of the active substance from the blood occurs within 6-20 hours, depending on the body and state of health. One third of the composition is excreted in the patient's urine. The rest of the substance is excreted through the feces.

Description of the drug and composition

The active ingredient in tablets is cinnarizine. The composition includes 25 mg of this element. The tablets also contain starch, silicon, lactose and povidone. The medicine is available in the form round tablets white. Cinnarizine is sold in blister packs and cardboard packaging.

Rules for storing medicine

Cinnarizine should be kept in its original packaging away from children. The storage temperature should not exceed 25 degrees. The shelf life of tablets from the date of production is 5 years.

Drug analogues

In the pharmacy you can find a lot of analogues of Cinnarizine, which have a similar effect. therapeutic effect. Typically, such drugs are prescribed if the patient is allergic to one of the components of the main medicine. Here is a list of all analogues:

1. Vasoserc;
2. Westinorm;
3. Daedalon;
4. Neurogin;
5. Stugeron;
6. Cinnaridone;
7. Other tablets for motion sickness in transport.

Every similar drug It has detailed instructions on use, its side effects and exact dosage. Be sure to read this information before treatment and consult your doctor.

Cinnarizine – medicine, blocking the so-called “slow” calcium channels, mainly in cerebral vessels. The drug inhibits the process of calcium entry into cells, reduces their concentration in plasmalemma depots, has a relaxing effect on the smooth muscle frame of small arteries, and potentiates the vasodilating effect of carbon dioxide. Directly affecting smooth muscles blood vessels, reduces their sensitivity to biogenic vasoconstrictor compounds (catecholamines). Shows a vasodilating effect (especially in relation to cerebral vessels), practically without affecting the indicator blood pressure. Exhibits antihistamine properties, reducing reactivity vestibular apparatus and sympathetic tone. Cinnarizine is effective in patients with hidden deficiency cerebral circulation, just incipient atherosclerosis of cerebral vessels, chronic vascular diseases and signs of post-stroke focal lesions. In patients with peripheral vascular lesions, cinnarizine improves blood supply to affected organs and tissues (including the heart) and enhances post-ischemic vasodilation. The drug increases the elasticity of erythrocyte membranes, their deformability, improves the rheological characteristics of blood, and increases muscle resistance to oxygen starvation. The maximum concentration of the active substance in the blood after oral administration is achieved after 1-3 hours. The drug is completely metabolized by microsomal liver enzymes. The half-life of cinnarizine is 2-4 hours. It is excreted by the intestines (most of it) and by the kidneys.

Cinnarizine is available in tablets. The drug should be taken after meals. For cerebral circulatory disorders - 25-50 mg three times a day, for circulatory disorders in peripheral vessels- 50-75 mg three times a day, for labyrinthine-vestibular dysfunctions - 25 mg three times a day, for kinetosis, before a planned trip, adults take 25 mg with the possibility of taking an additional dose after 6 hours, children take half of the indicated dose.

Maximum daily dose cinnarizine is 225 mg. At hypersensitivity The drug course begins with a half dose, gradually increasing it until an optimal therapeutic response is obtained. The duration of pharmacotherapy varies from 2-3 weeks to several months. On initial stage treatment, you should stop taking ethanol in any form. Due to the presence of antihistamine activity in cinnarizine, the drug may give positive result during a doping test for athletes, as well as to disguise positive reactions diagnostic skin tests(in this regard, treatment should be interrupted 4 days before the study). During long-term drug courses, it is recommended to periodically monitor functional indicators liver and kidneys, as well as a picture of peripheral blood. Patients suffering from Parkinson's disease should be prescribed cinnarizine with extreme caution. The drug potentiates the effect of ethanol, sedatives and antidepressants. When used together with nootropics, vasodilators and antihypertensive drugs, cinnarizine enhances their effect. Especially important role the drug plays a role in geriatric practice. Cerebrovascular insufficiency, which progresses with age, interferes with the normal blood supply to brain tissue, resulting in the gradual death of brain neurons. One of the reasons on which the severity of brain function disorders depends is atherosclerotic vascular changes. In some cases this factor begins to play a decisive role, as, for example, in senile dementia. The goal of treatment in elderly patients is to slow age-related structural and functional changes. Considering the direct effect of cinnarizine on the blood vessels of the brain, it is one of the most prescribed drugs for patients of this profile.

Pharmacology

Cinnarizine is a selective blocker of “slow” calcium channels, reduces the flow of calcium ions into cells and reduces their concentration in the plasmalemma depot, reduces the tone of the smooth muscles of arterioles, and enhances the vasodilating effect of carbon dioxide. Directly affecting the smooth muscles of blood vessels, it reduces their response to biogenic vasoconstrictors (adrenaline and norepinephrine). It has a vasodilating effect (especially in relation to cerebral vessels), without having a significant effect on blood pressure. Shows moderate antihistamine activity, reduces the excitability of the vestibular apparatus, reduces the tone of the sympathetic nervous system. Effective in patients with latent cerebrovascular insufficiency, initial cerebral atherosclerosis and chronic diseases cerebral vessels with post-stroke focal symptoms. In patients with impaired peripheral circulation, it improves blood supply to organs and tissues (including the myocardium), and enhances post-ischemic vasodilation. Increases the elasticity of red blood cell membranes, their ability to deform, and reduces blood viscosity. Increases muscle resistance to hypoxia.

Pharmacokinetics

Cmax in blood plasma is achieved after oral administration in 1-3 hours. Plasma protein binding is about 91%. Completely metabolized in the liver through dealkylation. T 1/2 - 4 hours. Excreted in the form of metabolites: 1/3 - by the kidneys, 2/3 - by the intestines.

Release form

Tablets are white or white with a creamy tint, flat-cylindrical, with a bevel.

Excipients: aerosil, calcium stearate, potato starch, lactose, low molecular weight medical polyvinylpyrrolidone.

50 pcs. - cans (1) - cardboard packs.
10 pieces. - contour cell packaging (5) - cardboard packs.

Dosage

Inside, after eating. For cerebrovascular accidents - 25-50 mg 3 times a day; for peripheral circulation disorders - 50-75 mg 3 times a day; for labyrinthine disorders - 25 mg 3 times a day; at sea and air sickness, before an upcoming trip for adults - 25 mg, if necessary, repeat the dose after 6 hours. Children are prescribed half the dose for adults. The maximum daily dose should not exceed 225 mg.

At high sensitivity treatment with the drug begins with 1/2 dose, increasing it gradually. The course of treatment ranges from several weeks to several months.

Overdose

Symptoms: vomiting, drowsiness, tremor, excessive decrease in blood pressure, coma. In case of overdose, there is no specific antidote; it is necessary to perform gastric lavage and take activated charcoal.

Treatment: symptomatic.

Interaction

Pharmaceutical: No chemical incompatibility known.

Pharmacodynamic: Strengthens the effect of alcohol, sedatives and antidepressants. When used simultaneously with nootropic, antihypertensive and vasodilators enhances their effect, and when used simultaneously with drugs prescribed for arterial hypotension, reduces their effect.

Pharmacokinetic: no data.

Side effects

From the nervous system: drowsiness, increased fatigue, headache, extrapyramidal disorders (tremor of the limbs and increased muscle tone, hypokinesia), depression.

From the outside digestive system: dry mouth, pain in epigastric region, dyspepsia, cholestatic jaundice.

From the outside skin: increased sweating, red lichen planus(rarely).

Allergic reactions: skin rash.

Other: decreased blood pressure, increased body weight, development of lupus-like syndrome.

Indications

• the period of convalescence after suffering an ischemic and hemorrhagic stroke, traumatic brain injury;
• encephalopathy;
• labyrinthine disorders (including for maintenance therapy for dizziness, tinnitus, nystagmus, nausea, vomiting of labyrinthine origin);
• migraine (prevention of attacks);
• Meniere's disease;
• sea ​​and air sickness (prevention);
• peripheral circulatory disorders (prevention and treatment) - obliterating endarteritis, thromboangiitis obliterans, Raynaud's disease, diabetic angiopathy, thrombophlebitis, trophic disorders, trophic and varicose ulcers, pre-gangrenous conditions, paresthesia, night cramps and coldness in the extremities.

Use for renal dysfunction long-term use A follow-up examination of renal function is recommended.

Use in children

special instructions

At the beginning of treatment, you should refrain from taking ethanol.

Due to the presence of an antihistamine effect, cinnarizine may affect the results of studies during anti-doping control of athletes ( false positive result), as well as neutralize positive reactions during skin diagnostic tests (treatment should be discontinued 4 days before the test).

Influence on the ability to drive vehicles and operate machinery.

During the treatment period, care must be taken when driving vehicles and engaging in other potentially dangerous species activities that require increased concentration and speed of psychomotor reactions.

Release form and packaging: Cinnarizine tablets have a round, biconvex shape. The color of the tablets is white. Available in blisters of 50 pieces.

Composition of tablets: cinnarizine, wheat starch, lactose, colloidal silicon dioxide, povidone K25, magnesium stearate.

Storage of the drug: The drug should be stored in a dry dark place out of reach of children at temperatures not exceeding 20 degrees Celsius. Store for no longer than three years.

Cinnarizine analogues: medicines taxes having similar composition: Vertizin, Stugeron, Tsinedil, Cinnaron, Cinnasan.

Cinnarizine price: the cost of the drug Cinnarizine can vary between 15-20 rubles, depending on the pharmacy.

pharmachologic effect

Thanks to the selective blocker of slow calcium channels, the flow of calcium ions into the cells is reduced and their content in the plasmalemma depot is reduced, while the muscle tone of the arterioles is reduced, and the vasodilating effect of carbon dioxide is enhanced. The drug has an active effect on the smooth muscles of blood vessels, reducing their response to nutrients.

The drug has a vasodilating effect and does not have a significant effect on blood pressure. It is able to exhibit antihistamine activity, reduce the excitability of the vestibular apparatus, and reduce the tone of the sympathetic nervous system. Cinnarizine tablets are very effective for both chronic and initial cerebral circulatory failure. Patients suffering from peripheral circulatory disorders can count on improved blood supply to tissues and organs. Cinnarizine has the ability to increase the elasticity of red blood cell membranes, as well as their ability to deform, and significantly reduces blood viscosity. Makes muscles resistant to hypoxia.

Pharmacokinetics

Resorption of the drug occurs in the intestines and stomach. The drug has its maximum effect in the blood plasma 1-3 hours after administration. Metabolization occurs in the liver. The drug is excreted in the form of metabolites, partly by the kidneys, and partly with feces.

Cinnarizine indications

Indications for use of Cinnarizine:

• post-stroke conditions;
• ischemic stroke;
• condition after traumatic brain injury;
• with dyscyclic encephalopathy;
• for vestibular disorders (dizziness, nystagmus, Meniere's disease, tinnitus, vomiting and nausea of ​​labyrinthine origin);
• migraine (to prevent attacks);
• for the prevention of kinetosis (air and seasickness, motion sickness);
• with senile dementia;
• for peripheral circulatory disorders, Raynaud's disease, thrombophlebitis, diabetic angiopathy, trophic disorders.

Contraindications

The drug is contraindicated during pregnancy, breastfeeding, and hypersensitivity.

Cinnarizine use

Use the drug orally, after meals. For patients suffering from cerebral circulatory disorders, 30-50 mg (1-2 tablets) three times a day are prescribed. For patients with impaired peripheral circulation, 50-70 mg (2-3 tablets) three times a day. For those who suffer vestibular disorders 25 mg three times a day. For kinetosis, adults take 25 mg 30 minutes before the trip, children take half this dose.

In case of high sensitivity to cinnarizine, the medicine should be taken with ½ dose, gradually increasing it. Treat with a course that can last several weeks or several months.

Pregnancy and breastfeeding (use)

The drug Cinnarizine is contraindicated for use in pregnant women and nursing mothers.

Overdose of Cinnarizine

The maximum permissible dose of the drug per day is not more than 225 mg (9 tablets). If an overdose occurs, you need to do a gastric lavage and drink activated charcoal.

Interactions of the drug with other drugs

Cinnarizine significantly enhances the effect of sedatives and alcohol. If the medicine is used together with antihypertensive, nootropic and vasodilator drugs, their effect is enhanced. When used together with drugs prescribed for arterial hypotension, their effect decreases.

Side effects of the drug

Possible side effects from the nervous system: headache, drowsiness, fatigue, extrapyramidal disorders (increased muscle tone, tremor of the limbs, hypokinesia).

Pain in the epigastric region, dry mouth, cholestatic jaundice, and dyspepsia are also possible.

From the skin: development of lupus-like syndrome, sweating, skin rash, lichen planus.

Frequent appearances allergic reactions, weight gain, decreased blood pressure...

Special instructions when using the drug

Since Cinnarizine has an antihistamine effect, it can affect the results of examinations during anti-doping control of athletes.

If you use Cinnarizine for a long time, you should conduct a control examination of kidney and liver function.

Patients suffering from Parkinson's disease should be prescribed the drug only when the benefits of its use outweigh the likely risk of worsening the condition.

It is very difficult for an infant to place correct diagnosis, and only specialists should do this. Disorders that are associated with the functioning of the child’s central nervous system require special attention. Today, many newborns, after a few days of life, receive a diagnosis of “increased intracranial pressure" And if this diagnosis does not change over a long period of time, hydrocephalus and expansion of the fluid cavities of the brain may result. Moreover, this expansion can occur due to a significant decrease in the mass of the brain matter. Such processes leave a negative imprint on the baby’s health. Moreover, the baby’s brain is not yet fully formed, and constant pressure provokes mental retardation.

The first one to turn Special attention on possible deviations in the development of a child, this is the mother. Moreover, the manifestation pathological changes very noticeable, so parents should immediately be alarmed and consult a doctor. The most clear symptoms: refusal to drink, fast growth head volume, strabismus, pupillary abduction, regurgitation, occasional vomiting, protrusion of the fontanelle, sleep disturbance. In such children, you can often notice increased excitability.

Can infants have cinnarizine?

The very first thing the doctor advises after treatment is to examine the baby using additional methods. For children under the age of 1 year, an ultrasound scan of the skull can be prescribed, since the fontanel is not yet completely overgrown.

If the diagnosis is confirmed, the baby is prescribed special drugs– diuretics. Today, the range of diuretics is very wide. Behind long years existence, cinnarizine for newborns has proven itself very well. The instructions for the drug clearly indicate that it should not be prescribed to children under 5 years of age. But experienced specialists know how to prescribe cinnarizine to infants and in what dosages.

How to give cinnarizine to a baby

For newborns, cinnarizine is prescribed strictly individually and only in cases where its benefit significantly outweighs the risk to the child’s health. Doctors always insist on urgent treatment infants, as it helps prevent irreversible damage to the central nervous system. If speak about side effects drug, it can be noted that they are minimal. Cinnarizine contains substances that improve blood circulation and nutrition of the brain; the drug acts as a sedative.

The duration of use of cinnarizine in newborns is not known exactly. After all, treatment can last several weeks or several months, depending on the severity of the disease.

Cinnarizine and exercises for infants

In order to increase the effectiveness of treatment, it is recommended to go swimming with your child along with cinnarizine. Thanks to swimming, your baby can get rid of excess muscle tension. Moreover, with muscle hypotonia, tone may increase. Daily therapeutic exercises will also give excellent results.

Treatment with medications, in combination with additional physical activity will help normalize the functioning of the baby’s central nervous system. And within a few months, parents will notice positive changes.

Cinnarizine for infants reviews

Bogdana After the birth of our baby, the doctors immediately noted that the child had oxygen starvation. In addition, the child experienced the following moments: shuddering during sleep, a sharp cry, and whimpering. I told the neurologist about these symptoms and, in addition to other medications, we were prescribed Cinnarizine. After reading the instructions, I doubted whether or not to give the drug to the baby, but I decided that if the doctor prescribed it, we would take it. After a few days of use, all the described symptoms disappeared, negative reaction it didn't happen to us. In addition, the cost of the tablets is only 20 rubles. I think these are the cheapest and very effective tablets.

Ira Malysh almost 2 months, we had an ultrasound of the brain. The result is a slight spasm of a cerebral vessel due to hepoxia. The neurologist prescribed cinnarizine at a dosage of 25% tablets twice a day in order to dilate the blood vessels for oxygen intake. There was no repeat ultrasound yet, but the baby began to sleep better and became calmer.

Larisa Burkina We had an incident where the baby fell on his head. They didn't look after the child. And any head injury is very dangerous, because it is unknown how and when it will manifest itself. In the neurosurgery department, where we were hospitalized with the child, the doctors taught me that if the child hit his head, an examination should be carried out, even if a bump did not appear on the head. Such an examination will not take much time, but you will know that the baby is fine. Along with other medications in neurosurgery, we were prescribed Cinnarizine, which we took for a month. As our attending physician said, this drug good for cerebrovascular disorders. And the pills helped us a lot. But still, before using the drug yourself, you should consult your doctor.

Single father The doctor prescribed Cinnarizine tablets for us when our daughter was less than a month. At an appointment with a neurologist, they diagnosed neuro-reflex excitability and prescribed Cinnarizine ¼ tablet once a day. But the instructions indicate that the drug should not be taken by children. How do doctors prescribe this? We, of course, did not give medicine to the baby. Now she is 8 months old, and since the age of two months everything has returned to normal. And there is no excitability. Since then we have not gone to neurologists.

Excipients: aerosil, calcium stearate, potato starch, lactose, low molecular weight medical polyvinylpyrrolidone.

50 pcs. - cans (1) - cardboard packs.
10 pieces. - contour cell packaging (5) - cardboard packs.

pharmachologic effect

Cinnarizine is a selective blocker of “slow” calcium channels, reduces the entry of calcium ions into cells and reduces their concentration in the plasma membrane depot, reduces the tone of the smooth muscles of arterioles, and enhances the vasodilating effect of carbon dioxide. Directly affecting the smooth muscles of blood vessels, it reduces their response to biogenic vasoconstrictors (and norepinephrine). It has a vasodilating effect (especially in relation to cerebral vessels), without having a significant effect on blood pressure. It exhibits moderate antihistamine activity, reduces the excitability of the vestibular apparatus, and lowers the tone of the sympathetic nervous system. Effective in patients with latent cerebral circulatory failure, initial cerebral atherosclerosis and chronic cerebral vascular diseases with post-stroke focal symptoms. In patients with impaired peripheral circulation, it improves blood supply to organs and tissues (including the myocardium), and enhances post-ischemic vasodilation. Increases the elasticity of red blood cell membranes, their ability to deform, and reduces blood viscosity. Increases muscle resistance to hypoxia.

Pharmacokinetics

Dosage

Inside, after eating. At cerebrovascular disorders- 25-50 mg 3 times a day; at peripheral circulatory disorders- 50-75 mg 3 times a day; at labyrinthine disorders- 25 mg 3 times a day; at sea ​​and air sickness, before the upcoming trip adults- 25 mg, if necessary, repeat the dose after 6 hours. For children Prescribe half the dose for adults. The maximum daily dose should not exceed 225 mg.

In case of high sensitivity to the drug, treatment begins with 1/2 dose, increasing it gradually. The course of treatment ranges from several weeks to several months.

Side effects

From the nervous system: drowsiness, increased fatigue, extrapyramidal disorders (tremor of the limbs and increased muscle tone, hypokinesia), depression.

From the digestive system: dry mouth, epigastric pain, dyspepsia, cholestatic jaundice.

From the skin: increased sweating, lichen planus (extremely rare).

Allergic reactions: skin rash.

Others: decreased blood pressure, increased body weight, development of lupus-like syndrome.

Overdose

Symptoms: vomiting, drowsiness, tremor, excessive decrease in blood pressure, coma. In case of overdose, there is no specific antidote; it is necessary to perform gastric lavage and take.

Treatment: symptomatic.

Drug interactions

Pharmaceutical: Chemical incompatibility is not known.

Pharmacodynamic: Strengthens the effect of alcohol, sedatives and antidepressants. When used simultaneously with nootropic, antihypertensive and vasodilator drugs, it enhances their effect, and when used simultaneously with drugs prescribed for arterial hypotension, it reduces their effect.

Pharmacokinetic: no data.

special instructions

At the beginning of treatment, you should refrain from taking ethanol.

Due to the presence of an antihistamine effect, cinnarizine can affect the test result during anti-doping control of athletes (false-positive result), as well as neutralize positive reactions during skin diagnostic tests (treatment should be discontinued 4 days before the test).

The drug Cinnarizine- a medicine that is prescribed mainly for the brain. This is a drug that inhibits the penetration of calcium ions into the muscle cells of the heart and blood vessels from the intercellular space. This achieves expansion coronary arteries and peripheral arteries and arterioles, a vasodilator effect is produced.

Some experts consider Cinnarizine obsolete and prefer to prescribe it for treatment over modern analogues, similar in mechanism of action and achieved effects. Let's look at what analogues of Cinnarizine exist and what can replace this drug if necessary.

Cavinton or Cinnarizine - which is better?

Cavinton is a drug whose main component is vinpocetine. It has neuroprotective and antioxidant effect, has a beneficial effect on blood circulation and metabolism in the brain, as well as on the rheological characteristics of the blood. Most often, this medicine is used for cerebral circulatory insufficiency accompanied by mental or neurological disorders.

Cavinton is similar in effect to Cinnarizine. However, at the same time, Cinnarizine has virtually no effect on blood pressure, which is valuable for the treatment of patients with blood pressure problems. Only a doctor can determine which drug is best to use, depending on the diagnosis and concomitant pathologies.

Cinnarizine or Vinpocetine – which is better?

Vinpocetine is used to correct cerebrovascular disorders. This natural preparation, the main ingredient of which is an alkaloid from the Vinca minor plant. The drug helps to increase blood supply to ischemic areas of the brain by relaxing vascular smooth muscles. The drug also has antiaggregation and antihypoxic effects.

Comparing the drugs Cinnarizine and Vinpocetine, it can be noted that the latter has a smaller amount side effects and is made from plant materials. In addition, when treating with Vinpocetine, patients with liver and kidney diseases do not require a dosage reduction. However, some experts question the effectiveness of Vinpocetine.

Piracetam, Cinnarizine or Phezam - which is better?

Piracetam is a medicine belonging to the group of nootropic drugs. The mechanism of its action is not completely clear, but it is believed that the drug has positive influence on metabolic processes and blood circulation in the brain, helps improve memory, attention, and mental activity.

Cinnarizine is not an analogue of Piracetam, but is often prescribed in combination with this drug. Concomitant use these drugs give a particularly high positive effect when chronic failure cerebral circulation. Phezam is a medicine containing as active ingredients piracetam and cinnarizine.

Cinnarizine or Mexidol - which is better?

Mexidol is a drug based on ethylmethylhydroxypyridine succinate, which has antihypoxic, nootropic, anticonvulsant, anxiolytic effects, and increases the body's resistance to stress. It also improves blood circulation in the brain and has a positive effect on the rheological properties of blood. The drug appeared relatively recently, and its research is still ongoing. As a rule, it is prescribed not as a monotherapy drug, but in combination with other drugs, one of which may be Cinnarizine.

Vasobral or Cinnarizine – which is better?

Vasobral is combination drug, which is prescribed for cerebrovascular accidents. It contains two active components: alphadihydroergocriptine (ergot derivative) and caffeine. The drug has an effect on the receptors of the central nervous system, helps reduce the permeability of vascular walls, thins the blood, improves blood circulation and metabolic processes in the brain. In addition, Vasobral provides preventive action at .

Comparing Cinnarizine and Vasobral, it is worth noting that the latter helps lower blood pressure, while Cinnarizine has almost no effect on it. Therefore, for hypotension, Cinnarizine can rather be recommended.