Lipotropic products: our helpers that break down fats. Lipotropic factor from Solgar - help with weight loss

What are lipotropic substances?

These vitamin-like substances choline, inositol, biotin and a/k methionine are lipotropic substances - that is, they are involved in fat metabolism, and their main function is to prevent abnormal or excessive accumulation of fat in the liver. They increase the production of lecithin, which keeps cholesterol more soluble, cleanses the liver and increases resistance to disease.

Because many of us eat too much fat, and most of it is saturated fat, then in this situation lipotropic substances are extremely necessary. Lipotropic substances are also necessary to maintain health, because they help thymus gland produce antibodies, stimulate the growth and activity of phagocytes (cells that surround and absorb viruses and microbes), help in the destruction of foreign and pathological tissue.

Biotin(coenzyme R or vitamin H)

Belongs to the B vitamins. Dose for adults is 150-300 mcg. Biotin is needed for synthesis ascorbic acid, necessary for normal metabolism of fats and protein. Can be synthesized by intestinal bacteria. Raw eggs interfere with its absorption by the body. Synergistic with vitamins A, B2, BB, niacin.

Biotin keeps skin healthy, protects hair from graying, relieves muscle pain, and reduces the manifestations of eczema and dermatitis.

Sources: nuts, fruits, brewer's yeast, beef liver, milk, kidneys and brown rice, egg yolk.

Kholin. Group B, lipotropic substance

Acts together with inosine, promoting the utilization of fats and cholesterol. One of the substances that can penetrate the so-called blood-brain barrier, which normally protects the brain from fluctuations in diet and goes directly into the brain cells in order to synthesize chemical compounds, helping to strengthen memory. Facilitates the work of the liver, helps remove poisons and drugs from the body.

Sources: egg yolk, brains, heart, green leafy vegetables, yeast, liver, wheat ovary, lecithin.

Folic acid(folacin). Group B

Folic acid is found in dark green leafy vegetables, carrots, yeast, liver, egg yolk, melon, apricots, pumpkin, avocado, beans, whole wheat and rye flour. It breaks down when cooked. If you drink alcohol regularly, you should increase your intake of folic acid.

Pharmacological action

• Not indicated. See instructions

Description of pharmacological action

Lipotropic factor contains three different substances that stimulate fat metabolism and help prevent fat accumulation - choline, inositol and methionine.
Choline, inositol and methionine are capable of removing fats from the liver. At the same time, methionine helps remove toxins produced during fat burning; if toxins are not removed, fat metabolism may be impaired. Can be used during weight loss and cholesterol reduction programs. Use for weight loss can be combined with physical exercise.
Inositol increases the body's production of lecithin. Thus, inositol promotes fat metabolism and may reduce blood cholesterol levels. Together with choline, it helps prevent the accumulation of fats in the arteries ( arterial vessels) and supports heart and kidney health. Inositol simultaneously promotes brain cell nutrition, development and protection bone marrow, eye membrane and intestinal cells. It is also needed for healthy hair.

Compound

Choline bitartrate, inositol, L-methionine, MCC, vegetable cellulose, magnesium stearate, silicon dioxide, titanium dioxide, glycerin.

Release form

tablets 1600 mg;

Directions for use and doses

Adults: 1 tablet 3 times a day with meals.

Storage conditions

In a dry place, protected from light, at a temperature of 15–30 °C.

Best before date

Description of the vitamin Lipotropic factor is intended for informational purposes only. Before starting to use any drug, it is recommended to consult a doctor and read the instructions for use. To get more complete information Please refer to the manufacturer's instructions. Do not self-medicate; EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the project does not replace consultation with a specialist and cannot be a guarantee of the positive effect of the drug you use. The opinions of EUROLAB portal users may not coincide with the opinions of the site Administration.

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Add the formula

Liver steatosis (fatty liver disease, fatty liver) is the most common hepatosis, in which fat accumulates in the liver cells. Fat accumulation may be a reaction of the liver to various toxic effects, sometimes this process is associated with certain diseases and pathological conditions body.

Lipotropic substances are important factors, which contribute to the normalization of lipid and cholesterol metabolism in the body, stimulate the mobilization of fat from the liver and its oxidation, which leads to a decrease in the severity of fatty infiltration of the liver. According to the anatomical-therapeutic-chemical classification they belong to the group A05- drugs for the treatment of diseases of the liver and biliary tract, so they can be considered hepatoprotectors. Currently, the modern pharmaceutical industry is synthesizing drugs that have a lipotropic effect.

LIPOTROPIC FACTORS ARE SUBSTANCES THAT PROMOTE FAT BURNING

Lipotropic effects are exerted by:

carnitine

methionine

thioctic acid

And other substances contained in protein products. [ source not specified 442 days] They are rich in beef, chicken eggs, low-fat fish (cod, pike perch), marine invertebrates, low-fat cottage cheese, soy flour.

12. b-hydroxybutyrate----acetoacetate-----acetoacetyl-s-CoA-----acetyl-CoA------TCA cycle
26atf

13. The term “ketone bodies” means the following compounds: acetoacetic acid (acetoacetate), β-hydroxybutyric acid (β-hydroxybutyrate), acetone. These are products of incomplete oxidation of fatty acids. Their synthesis occurs in liver mitochondria from acetyl-CoA.

see formula from 1 question.

The synthesis of ketone bodies in the body increases with accelerated catabolism of fatty acids (fasting, diabetes). Under these conditions, the liver has a deficiency of oxaloacetate, which is formed mainly in carbohydrate metabolism reactions. Therefore, the interaction of acetyl-CoA with oxaloacetate and all subsequent reactions of the Krebs tricarboxylic acid cycle are hampered.

Acetoacetic and β-hydroxybutyric acids, which are classified as ketone bodies, are strong acids. Therefore, their accumulation in the blood leads to a shift in pH to the acidic side (metabolic acidosis).

Normal is 1-3 mg/dl (up to 0.2 mmol/l)

15. The starting compound for cholesterol synthesis is acetyl-CoA. Enzymes that catalyze synthesis reactions are found in the cytoplasm and endoplasmic reticulum of many cells. This process occurs most actively in the liver. The human body synthesizes about one gram of cholesterol per day. Cholesterol biosynthesis includes three main stages.

On first stage mevalonic acid is formed

On second stage mevalonic acid is converted to isopentenyl pyrophosphate (“active isoprene”), 6 molecules of which condense into squalene.

On third stage squalene turns into cholesterol

In total, 18 molecules of acetyl-CoA are used to synthesize 1 molecule of cholesterol: 3 molecules are required to form “active isoprene”; 6 molecules of “active isoprene” participate in subsequent condensation reactions; 3 × 6 = 18.

16. Cholesterol is a component of biological membranes, from which steroid hormones, vitamin D 3, and bile acids are formed in the body. Excess cholesterol is converted in the liver into bile acids, and is also excreted with bile into the intestines and excreted in feces.

Normal content cholesterol in human serum is 3.9 – 6.3 mmol/l. The transport form of cholesterol in the blood is lipoproteins (see further 16.5.2). If the relationship between the entry of cholesterol into the body and its excretion is disrupted, then the cholesterol content in the tissues and blood changes. Increased cholesterol concentration in the blood ( hypercholesterolemia) can lead to the development of atherosclerosis and gallstone disease.

To restore 1 mol of β–hydroxy-β-methylglutaryl-CoA to mevalone acid,-2 mol NADPH 2

The donor of the methyl group in the image of phosphatidylcholine from phosphatidylethanolamine is S-adenosine methionine

Daily loss of bile acids with feces is 0.5-1.0 g

Number of mol of ATP, image at oxidation of 1 mol of acetoacetate to CO 2 and H 2 O state - 24

Lipotrop is a fact of the way - phospholipid synthesis in the liver

Norm value of cholate-cholesterol coefficient 15

The common predecessor for phosphatidylcholine synth and sphingomyelin is CDP-choline

The general metab for triacylglycerols and phospholipids is phosphatidic acid

The general intermediate between triacylglyc and phospholip is diacylglycerol phosphate

The basic function of phospholip in org is in post-cell membranes and blood lipoproteins

One of the con prod katabs of cholesterol in people is-cholic acid

Mainly by removing cholesterol from the human body-collect gallstones and excrete them with feces

When β-hydroxy-β-methyl-glutaryl-CoA is reduced, the mevalonic acid

Regulus farms, limited synthesis of cholesterol, yavl-Hydroxy-b-methylglutaryl-CoA reductase

The regulation of cholesterol synthesis from acetyl-CoA is carried out at a high level-mevalonic acid from b-hydroxy-β-methyl-glutaryl-CoA

The synthesis of ketone bodies occurs in- liver

Physiol corresponds to the normal level of cholesterol in the blood plasma-3.9-6.5 mmol/l

Select all correct answers:

The synthesis of phospholipids involves:

1. CoA derivatives of fatty acids

2. phosphatidic acid

3. CDP-choline

Phospholipids contain alcohols:

1. ethanolamine

2. glycerol

3. sphingosine

4. inositol

To synthesize one cholesterol molecule you need:

1. 18 ATP molecules

2. 18 molecules of acetyl-CoA

Ketone bodies are:

1. β-Hydroxybutyrate

2. acetoacetate

Which of the following statements correctly characterize ketone bodies:

1. formed in liver mitochondria

2. synthesized from acetyl-CoA

3. used as a source of energy in skeletal and cardiac muscles

1. methionine

2. folic acid

Phospholipids include:

1. glycerophosphatides

2. phosphoinositols

3. sphingomyelins

Lipotropic factors include:

3. methionine

Common intermediates in the synthesis of glycerophospholipids and triacylglycerols are:

1. diacylglycerol

2. phosphatidic acid

Intermediate metabolites in the synthesis of ketone bodies from acetyl-CoA are:

1. β–hydroxy-β-methylglutaryl-CoA

2. acetoacetyl-CoA

Intermediate products in cholesterol synthesis are:

1. mevalonic acid

2. β–hydroxy-β-methylglutaryl-CoA.

3. acetoacetyl-CoA

Intermediate products in the process of cholesterol synthesis are:

1. lanosterol

2. acetoacetyl-CoA

3. mevalonic acid

4. squalene

Strengthening the processes of ketogenesis is characteristic of:

1. heavy physical work

2. fasting

3. diabetes mellitus

Phosphatidic acid (diglycerol phosphate) is an intermediate metabolite in the biosynthesis of:

1. triacylglycerols

2. phospholipids

Phosphatidylcholines and phosphatidylethanolamines are synthesized in:

3. adrenal cortex

4. renal cortex

1. used for synthesis bile acids

Cholesterol in the human body:

1. used for the synthesis of vitamin D 3

2. used for the synthesis of steroid hormones

3. included cell membranes

Cholesterol is synthesized in:

3. adrenal glands

4. adipose tissue

1. synthesis of ketone bodies

2. cholesterol synthesis

b-hydroxy-b-methyl-glutaryl-CoA is an intermediate metabolite in the process:

1. synthesis of ketone bodies

2. cholesterol synthesis

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A truly effective fat burning process is impossible without help. sports supplements. No matter how intensely you exercise, no matter how long you follow a strict diet, really worthwhile results get it only through additional intake of special biologically active complexes. There are many such drugs available today. Let's talk about a specific group of supplements - lipotropics.

Photo: lipotropic fat burners

What are lipotropics

The advantage of lipotropics over other sports fat burners is that their use for humans can be said to be quite natural, since all these substances have natural origin. Drugs with a lipotropic effect do not create a stressful overload for the body and do not force it to work to the limit own strength and resources. In addition, they are safe and much more effective than thermogenic fat burners.

The benefits of lipotropics for women

In addition to stimulating the process of breakdown of adipose tissue cells, lipotropics, when entering the human body, exhibit many other equally valuable functions. They activate the activity of a mass of enzymes involved in the processing of fats; improve liver function by protecting organ cells from harmful effects toxins. Lipotropics increase immunity and endurance, eliminate inflammatory processes, excellent toning.

The beneficial properties of drugs that increase the intensity of metabolism largely depend on the specific type of compound from the group of substances we are considering. By the way, the latter are of organic and mineral origin.

Lipotropic substances are important factors that contribute to the normalization of fat and, in particular, cholesterol metabolism in the body. They stimulate the release of fat from the liver and its oxidation, which leads to a reduction in its fatty infiltration.
The following substances have a lipotropic effect: choline, methionine, inositol, lecithin, betaine, etc., contained in protein products. Beef is rich in them, chicken eggs, low-fat fish (cod, pike-perch), marine invertebrates, low-fat cottage cheese, soy flour.
Lecithin is found in large quantities in unrefined vegetable oils and in the phosphatide concentrate isolated from them. A particularly rich source of lecithin is buttermilk, obtained from the process of churning cream into butter. In terms of protein, fat and milk sugar she is no different from skim milk, but almost all lecithin passes into it, maintaining the milk fat of the cream in an emulsified state.
All of the listed food products, rich in certain lipotropic substances, are necessarily included in diets for patients with metabolic disorders (hypertension, atherosclerosis, obesity) and liver diseases. In addition to the listed substances, polyunsaturated compounds also have lipotropic and anticholesterolemic (promoting the removal of cholesterol from the body) effects. fatty acid, sitosterols and some minerals, in particular organic compounds Yoda.
Besides, effective means to remove cholesterol from the body are plant foods rich in cell membranes and pectin, which enhance intestinal motor activity.
Essential polyunsaturated fatty acids - linoleic and linolenic - are not synthesized in the body, but are introduced exclusively with food. Their main source is vegetable oils- sunflower, corn, cotton, etc.
Plant sterols - sitosgerins, forming insoluble complexes with cholesterol, prevent its absorption in the intestines and thereby promote the removal of cholesterol from the body. Sitosterols are found in unrefined vegetable oils.
To enrich diets with all these substances, a number of specific products are used - non-fat deodorized soy flour, wheat bran, phosphatide concentrate, dry seaweed. These products are used in small quantities, mainly as additives to dough when preparing flour products.
In assortment bakery products industrial production available dietary varieties, which include phosphatides, soy flour, wheat bran, seaweed (buns with lecithin, bran bread with lecithin and seaweed, protein-bran bread, etc.).
IN last years V therapeutic nutrition for metabolic diseases, seafood products of both plant and animal origin began to be used more and more widely. From plant products seaweed is widely used, and among animals - shellfish: mussels, scallops, squid and crayfish: shrimp, krill, etc.
All seafood products - the most valuable sources minerals, including microelements, mainly iodine. In addition, sea kale, due to its significant content alginic acid(15-30% of dry matter) has a stimulating effect on intestinal peristalsis. Application seaweed in powder form is not physiological, therefore it is used as an additive in culinary, confectionery and bakery products.

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