Acc analogues are cheap for cough. What is better to choose Lazolvan or ACC? Preparations with ambroxol

Everyone knows that coughing and mucus production is a protective reaction of the body. It is also well known that the treatment of these conditions must begin with establishing the cause. But not everyone knows the advisability of using mucolytics Fluimucil or ACC - agents that dilute sputum to facilitate its separation, although complex treatment respiratory tract These drugs have a significant impact on the success of the enterprise.

Firstly, they enhance the effectiveness of mechanical removal, along with mucus and phlegm, of foreign agents and toxins, in fact, what the body coughs and “sniffles” for (by the way, they are also used with great success to treat ENT diseases). Secondly, the mucus and sputum itself, produced in the upper and lower respiratory tracts, contains immunoglobulins, lysozyme, opsonins, which lose their bactericidal and barrier properties if the secretion is excessively viscosity. So, in order to increase the productivity of natural defense mechanisms and mucolytic agents are prescribed, the most popular representatives of which in our country are ACC or Fluimucil with a good safety profile and proven effectiveness. Let's look at their similarities and differences.

Fluimucil and ACC - what is the difference?

Forms of release and their diversity - this is where we can see clear difference Fluimucil from ACC. Both drugs are presented in various variations, allowing their use depending on age and method of delivery to the body. To make it easier to navigate, let’s imagine the difference between their rulers in the form of a table.

The table shows that ACC has a larger range of release forms and flavors than Fluimucil. All ACC forms In addition to syrup, they are available in different doses of acetylcysteine, flavors and even temperatures ready drink. This allows you to calculate the dosage more flexibly, which is especially important in childhood (you can give not only syrup, but also effervescent tablets or granules of 100 mg). It is more convenient for adults to manage the number of doses per day, for example, you can take 200 mg tablets 3 times a day, or you can take ACC Long containing ACC only once a day. daily norm acetylcysteine. Fluimucil effervescent tablets, on the contrary, are available only in high dose, designed for one appointment.

However, Fluimucil has a very important advantage - it is produced in ampoules, the solution from which is also used for inhalation. Naturally, the shorter and more natural method of delivery to the respiratory tract has a positive effect on its speed of action and effectiveness compared to oral forms. This is especially true in acute conditions.

What is better for children - ACC and Fluimucil?

Both drugs are contraindicated in children under two years of age. Correct selection the quantities in each specific case should be determined by a pediatrician; the recommended dosages of acetylcysteine, which should not be exceeded regardless of the release form of Fluimucil or ACC, are as follows:

• from 2 to 6 years - 2-3 times a day, 100 mg (total 200-300 mg per day);
• from 6 to 14 years - 3 times a day 100 mg or 2 times 200 mg (total 300-400 mg per day);
• over 14 years old - 2-3 times a day, 200 mg (total 400-600 mg per day).

In general, despite the fact that ACC and Fluimucil are the same thing, the former offers a greater variety of types of medicine and its tastes for children younger age, including cherry syrup, which comes with a measuring device (syringe or measuring cap) in the package, allowing you to dose the medicine correctly.

Drinking plenty of fluids is one of the keys to the success of treatment with acetylcysteine-based mucolytics. Alkaline ones help them with this best mineral water. Also, to increase the effectiveness of therapy, it is desirable to maintain optimal air humidity in the room.

What is the difference in contraindications and price between Fluimucil and ACC?

Both mucolytics are contraindicated in case of hypersensitivity to acetylcysteine ​​or auxiliary components; up to two years of age (up to 14 years in 600 mg tablets), pregnant and lactating women (in special cases strictly under the supervision of a doctor); For separate forms ACC: fructose intolerance, glucose-galactose deficiency.

As for the question of choosing Fluimucil or ACC - which is better to buy, the situation here is ambiguous. In almost all similar forms of release, Fluimucil will be only slightly cheaper than its opponent. But for a package of 10 effervescent tablets of 600 mg - Fluimucil or ACC Long, the former will cost almost half the price. Most likely, such a significant difference is associated with the country of production, because in the same dosage (600 mg), but in packages of 20 tablets, these drugs cost almost the same. Thus, if you need long-acting effervescent tablets for adults, it is more profitable to take Fluimucil in 10 pieces; in other cases, the price difference is insignificant.

And we also have

ACC is a popular drug that is prescribed for coughs accompanied by difficult to clear sputum. On pharmacy counters, the product can be found in the form of powder, syrup, and effervescent tablets. The cost of the medication depends on the form of release, and is quite high. There are more cheap analogues ACC, which are not inferior to it in their ability to facilitate the passage of mucus.

Indications for use and cost

ACC – effective medicine, containing the substance acetylcysteine, has the following properties:

• promotes expectoration of viscous sputum;
• relieves inflammation;
• stimulates the thinning of mucus;
• helps remove secretions from the respiratory system;
• eliminates toxicity;
• relieves cough;
• restores damaged mucous membranes.

The therapeutic effect can be felt already on the second day of administration. Many patients note the appearance of a wet cough, a decrease in swelling and an improvement in their general condition.

The medication is prescribed for everyone infectious diseases, characterized by difficult-to-clean mucus in the bronchi.

Indications for use are:

• various types of bronchitis;
• pulmonary obstruction;
• pneumonia;
• bronchial asthma;
• sinusitis;
• otitis;
• laryngotracheitis and other diseases.

The drug can be taken by babies from the third week of life. That is why various forms of release are provided.

• The medicine in the form of granules is sold at a price of 122-185 rubles. depending on the number of sachets in the package.
• Effervescent tablets Long-600 No. 20 can be purchased at a price of 517 rubles.
• The average cost of syrup is 346 rubles.

Which is better, ACC or similar drugs? It is impossible to answer this question unambiguously, since a certain remedy is suitable for each patient, depending on the severity of symptoms and health status.

What to replace

Most often, patients look for a replacement product after finding out its price or when negative effects after the reception. In this case, your doctor may advise inexpensive analogue ACC with the same active substance or a product with another active ingredient.

You can replace effervescent tablets with other medications with a similar expectorant effect. These drugs have the same release form and dosage of 600 mg, but their cost is slightly lower:

• Acetylcysteine, 24 pieces is sold at a price of 233 rubles;
• Fluimucil effervescent tablets, 10 pieces - 138 rubles each;
• Vicks asset Expectomed can be found in online stores from 113 rubles.

Cheap analogues of ACC Long-600 can be purchased at any pharmacy, having previously notified the attending physician.

Fluimucil

One of the popular analogues is the Swiss-made medicine Fluimucil, which has the same active substance and about the same cost. Effervescent tablets, solution and powder can be purchased in the range of 164-446 rubles, depending on the form of release.

The drug promotes the secretion of purulent mucus and increases the volume of sputum. Can be used by children from 6 years of age.

Which medication to choose, Fluimucil or ACC? After using both substances, relief occurs already on the second day. The difference between the drugs is that Fluimucil is additionally produced in the form of a solution for inhalation, ACC - in the form of syrup. Many people prefer the second medicine, since the syrup is more suitable for use in childhood.

The product with the active ingredient of the same name is sold in the form of powder and effervescent tablets. Used for all diseases accompanied by mucopurulent secretion in the respiratory tract.

Granules and dissolvable tablets can be purchased at a price of 117-233 rubles.

Other analogues containing the active component acetylcysteine ​​are:

• Mukobene;
• Tussicom;
• Mucomist;
• Exomyuk;
• Atsestad;
• Acestine.

All medications are similar therapeutic effect. Their differences may lie in auxiliary ingredients and dosages of the active substance.

Cough analogues

On the advice of a doctor, the prescribed medicine can be replaced with another analogue of ACC for cough, which will have a similar effect, but may contain a different active ingredient.

Medicines containing ambroxol

Such medicines are not structural analogues of ACC, and are produced in different countries. These drugs have a mucolytic effect, thinning mucus, but the mechanism of drug action may differ.

• Lazolvan helps eliminate bacteria and removes toxins. Can be used from early childhood. Sold in the form of a solution for inhalation, syrup, tablets and capsules. Price – 170-394 rubles.
• Ambrohexal in the form of solution, tablets and syrup also belongs to expectorants. Used for bronchitis, viral infections and other pathologies respiratory system. Side effects include allergic reactions. Significantly cheaper than its analogue: from 98 to 220 rubles, depending on the form of release.
• Salbroxol is a mucolytic substance used for bronchitis. Has anti-inflammatory and expectorant properties. The cost is very small - 50-80 rubles.
• Ambrobene is an effective mucolytic that helps eliminate inflammatory processes and swelling in the throat. Can be used in very young patients, including infancy. All forms of release have a fairly high cost.

When choosing a cough remedy, it is important to understand its difference from other drugs. The medications have either mucolytic or antitussive properties and cannot be taken together.

Medicines containing bromhexine

Products containing the active ingredient bromhexine will help ease coughing and extract bronchial secretions. These include:

• Solvin. Indications are various pathologies lungs, accompanied by viscous sputum. The tablets promote expectoration, have a mucolytic effect, and reduce swelling of the mucous membranes. Acceptable for children over 12 years of age.
• Ascoril contains 3 active components- salbutamol, guaifenesin, and bromhexine. It is used for cough reflexes provoked by acute and chronic bronchopulmonary pathologies with viscous sputum. Relaxes the smooth muscles of the bronchi, prevents spasms, improves the passage of sputum.
• Bromhexine Akrikhin. Increases the volume of mucus and promotes the removal of phlegm. Therapeutic effect is felt after 2-5 days from the start of treatment. Indications are tracheobronchitis, tuberculosis, pneumonia and other diseases of the pulmonary tract.
• Bromhexine Berlin-Chemie. Excellent analogue ACC for children. Can be prescribed to children from the age of two. Intended for the treatment of various bronchopulmonary diseases accompanied by viscous secretions. Not recommended in the first trimester of pregnancy, as well as ulcerative pathologies in the acute stage.

Like acetylcysteine, bromhexine helps remove purulent mucus and thins thick sputum, but the list of restrictions on the use of drugs based on it is much longer. It is worth noting that some dosage forms with bromhexine are cheaper than ACC.

Plant-based analogues

Some patients are confident that the pills prescribed by the doctor can be replaced with others herbal remedies, and also believe that such medications have a better effect on the body and have fewer contraindications. However, only the attending physician should make this decision.

There are many medications with herbal extracts that stimulate sputum production and help remove mucus from the respiratory system. The most common are:

• Gedelix syrup contains ivy leaf extract. Despite the high cost, it is very popular among adults and children. Successfully removes phlegm and has an antispasmodic effect.
• One more effective means is Prospan syrup. Applicable as additional remedy with exacerbation of inflammatory processes, sore throat. Contains dried ivy raw materials. Price of this medicine quite high.
• Gerbion syrup – effective drug from any type of cough. It thins mucus, eliminates coughing attacks, helps reduce shortness of breath, and has antispasmodic properties.

ACC and its analogues are taken in the stage of transition of cough to wet and productive. Assign necessary medication should only be done by a specialist, based on the examination, diagnosis and complaints of the patient.

The cheapest analogues

On pharmacy counters you can find a huge number of drugs, the action of which is aimed at eliminating cough and relieving inflammatory processes. However, drug prices vary significantly.

• Most cheap substitute ACC – drug Russian production Mukaltin. You can buy it for 29 rubles. Active component Marshmallow is a medicinal plant that promotes the removal of mucus and relieves inflammation. Prescribed for wet cough.
• Another inexpensive medicine, dilutes sputum and removes it from the respiratory system - Pectusin. The composition includes plant extracts - thyme, thyme, as well as sugar syrup and ethanol. Due to this, it is not used during pregnancy and breastfeeding.
• Successfully separates sticky sputum drug Bromhexine. Prescribed for bronchitis, asthma, pneumonia. Cost – from 35 rubles.
• A mucolytic medication that successfully relieves severe cough during pneumonia and tuberculosis is Ambroxol. Ukrainian-made tablets can be purchased at the same price as Mukaltin.
• Pertussin is produced in the form of a sweet syrup. The active ingredient is thyme. Can be prescribed during pregnancy and for young children. You can buy it at a fairly low cost.

You should not change your prescribed cough medicine on your own. To do this, you need to carefully read the instructions for the drug, and also get advice from a specialist. The doctor will help you choose necessary remedy, based on the individual characteristics of the patient and clinical picture diseases.

In this article you can find instructions for use medicinal product ACC. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of ACC in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. ACC analogues in the presence of existing structural analogues. Use for the treatment of bronchitis and dry cough in adults, children, as well as during pregnancy and lactation. Various shapes release of a drug to thin sputum.

ACC- mucolytic drug. The presence of sulfhydryl groups in the structure of the acetylcysteine ​​molecule promotes the rupture of disulfide bonds of acidic mucopolysaccharides of sputum, which leads to a decrease in the viscosity of mucus. The drug remains active in the presence of purulent sputum.

At prophylactic use acetylcysteine ​​there is a decrease in the frequency and severity of exacerbations in patients with chronic bronchitis and cystic fibrosis.

Compound

Acetylcysteine ​​+ excipients.

Indications

• respiratory diseases accompanied by increased formation of viscous mucus that is difficult to separate (acute and chronic bronchitis, obstructive bronchitis, pneumonia, bronchiectasis, bronchial asthma, bronchiolitis, cystic fibrosis, laryngitis);
• acute and chronic sinusitis;
• Otitis media

Release forms

Powder or granules for making syrup 100 mg.

Syrup 100 ml.

Effervescent tablets 100 mg, 200 mg, 600 mg long.

Solution for injection ACC injection - 100 mg and 300 mg in 1 ml.

Instructions for use and dosage

Powder or effervescent tablets

Adults and adolescents over 14 years of age are recommended to prescribe the drug 200 mg 2-3 times a day (ACC in the form of granules for the preparation of an oral solution / orange / 100 mg and 200 mg), or 200 mg 3 (ACC in the form of granules for preparing a solution for oral administration 200 mg) or 600 mg 1 time per day (ACC in the form of granules for preparing an oral solution 600 mg).

Children aged 6 to 14 years are recommended to take 100 mg 3 times a day or 200 mg 2 times a day (ACC in the form of granules for oral solution / orange / 100 mg and 200 mg), or 200 mg 2 times a day (ACC in the form of granules for the preparation of a solution for oral administration 200 mg).

There is not enough data on the dosage of the drug in newborns.

For cystic fibrosis, children over 6 years of age are recommended to take the drug 200 mg 3 times a day (ACC in the form of granules for preparing an oral solution /orange/ 100 mg and 200 mg or ACC in the form of granules for preparing an oral solution 200 mg ).

Children aged 2 to 5 years - 100 mg 4 times a day (ACC in the form of granules for the preparation of an oral solution / orange / 100 mg and 200 mg).

For patients weighing more than 30 kg with cystic fibrosis, if necessary, the dose can be increased to 800 mg per day.

For sudden short-term colds, the duration of use is 5-7 days. At chronic bronchitis and cystic fibrosis, the drug should be used for a longer period of time to prevent infections.

The drug should be taken after meals. Additional fluid intake enhances the mucolytic effect of the drug.

Rules for preparing the drug

ACC in the form of granules for the preparation of a solution for oral administration /orange/ 100 mg and 200 mg: 1/2 or 1 sachet (depending on the dose) dissolved in water, juice or iced tea and taken after meals.

ACC in the form of granules for the preparation of a solution for oral administration 200 mg and ACC in the form of granules for the preparation of a solution for oral administration 600 mg: 1 sachet is dissolved with stirring in 1 glass hot water and drink it hot if possible. If necessary, you can leave the prepared solution for 3 hours.

Syrup

Adults and adolescents over 14 years of age are prescribed 10 ml of syrup 2-3 times a day (400-600 mg of acetylcysteine).

Children aged 6 to 14 years - 5 ml of syrup 3 times a day or 10 ml of syrup 2 times a day (300-400 mg of acetylcysteine).

Children aged 2 to 5 years are prescribed 5 ml of syrup 2-3 times a day (200-300 mg of acetylcysteine).

For cystic fibrosis, children over 6 years of age are recommended to take the drug 10 ml of syrup 3 times a day (600 mg of acetylcysteine); children aged 2 to 6 years - 5 ml of syrup 4 times a day (400 mg of acetylcysteine).

For short-term colds, the duration of use is 4-5 days. For chronic bronchitis and cystic fibrosis, the drug should be used for a longer period of time to prevent infections. For long-term illnesses, the duration of therapy is determined by the attending physician.

The drug is taken orally after meals. Additional fluid intake enhances the mucolytic effect of the drug.

ACC syrup is taken using a measuring syringe or measuring cup contained in the package. 10 ml of ACC syrup corresponds to 1/2 measuring cup or 2 filled syringes.

Using a measuring syringe

1. Open the bottle cap by pressing on it and turning it counterclockwise.

2. Remove the cap with the hole from the syringe, insert it into the neck of the bottle and press in until it stops. The stopper is designed to connect the syringe to the bottle and remains in the neck of the bottle.

3. It is necessary to insert the syringe tightly into the stopper. Carefully turn the bottle upside down, pull the syringe plunger down and draw the required amount of syrup (ml). If air bubbles are visible in the syrup, press the plunger all the way and then refill the syringe. Then return the bottle to its original position and remove the syringe.

4. The syrup from the syringe should be poured onto a spoon or directly into the child’s mouth (into the cheek area, slowly, so that the child can swallow the syrup). While taking the syrup, the child should be in an upright position.

5. After use, you should rinse the syringe clean water.

Ampoules for injections

Adults are prescribed intravenously or intramuscularly at 300 mg (1 ampoule) 1-2 times a day.

Children aged 6 to 14 years are prescribed IV or IM 150 mg (1/2 ampoule) 1-2 times a day.

For children under 6 years of age, oral therapy is preferred, however, if indicated and the need for parenteral administration daily dose is 10 mg/kg body weight.

For children under 1 year of age, intravenous administration of the drug is possible only for health reasons in a hospital setting.

The duration of therapy is determined individually.

For chronic bronchitis and cystic fibrosis application of ACC INJECT for a long time can be combined with oral administration of the drug to prevent infections.

The mucolytic effect of acetylcysteine ​​increases with increased fluid intake.

Rules for injections

With intramuscular injection when performing a shallow injection and in the presence of hypersensitivity A slight and quickly passing burning sensation may occur, so it is recommended to administer the drug to patients in a lying position and deep into the muscle.

For intravenous administration, the first dose must be diluted with 0.9% sodium chloride solution or 5% dextrose solution in a 1:1 ratio. The drug should, if possible, be administered by infusion.

IV injections should be administered slowly (over 5 minutes).

Side effect

• headache;
• noise in ears;
• stomatitis;
• diarrhea;
• vomit;
• heartburn;
• nausea;
• drop in blood pressure;
• tachycardia;
• development pulmonary hemorrhage as a manifestation of a hypersensitivity reaction;
• bronchospasm (mainly in patients with hyperreactive bronchial system at bronchial asthma);
• skin rash;
• hives.

Contraindications

• peptic ulcer and duodenum in the acute phase;
• hemoptysis;
• pulmonary hemorrhage;
• pregnancy;
• lactation period (breastfeeding);
• children under 2 years of age (the drug is in the form of granules for the preparation of a solution for oral administration /orange/ 100 mg and 200 mg, syrup and ACC 200);
• children under 6 years of age (the drug is in the form of granules for the preparation of a solution for oral administration, 200 mg);
• children under 14 years of age (the drug in the form of granules for the preparation of a solution for oral administration 600 mg and ACC Long);
• hypersensitivity to acetylcysteine ​​and other components of the drug.

Use during pregnancy and breastfeeding

Due to insufficient data, the use of the drug during pregnancy is contraindicated.

For syrup: use of the drug during pregnancy is possible only if the expected benefit to the mother outweighs the potential risk to the fetus.

If it is necessary to use the drug during lactation, the issue of stopping breastfeeding should be decided.

Use in children

Contraindicated for children under 2 years of age (the drug in the form of granules for the preparation of an oral solution /orange/ 100 mg and 200 mg, syrup and ACC 200), up to 6 years of age (the drug in the form of granules for the preparation of an oral solution 200 mg) , up to 14 years (the drug in the form of granules for the preparation of a solution for oral administration 600 mg and ACC Long).

special instructions

For bronchial asthma and obstructive bronchitis acetylcysteine ​​should be prescribed with caution under systematic monitoring of bronchial patency.

Severe allergic reactions such as Stevens-Johnson syndrome and Lyell's syndrome have been very rarely reported with the use of acetylcysteine. If changes in the skin and mucous membranes occur, the patient should immediately stop taking the drug and consult a doctor.

When dissolving the drug, it is necessary to use glass containers and avoid contact with metals, rubber, oxygen, and easily oxidized substances.

You should not take the drug immediately before bedtime ( preferred time reception - until 18.00).

If side effects develop, you should stop taking the drug.

ACC (in the form of granules for the preparation of solution for oral administration / orange / 100 mg and 200 mg) 100 mg corresponds to 0.24 XE, 200 mg - 0.23 XE.

Impact on the ability to drive vehicles and operate machinery

Information about the effect of the drug on the ability to drive vehicles and potentially engage with others dangerous species There are no activities requiring increased concentration and speed of psychomotor reactions.

Drug interactions

With the simultaneous use of acetylcysteine ​​and antitussives, due to suppression of the cough reflex, dangerous stagnation mucus (use combination with caution).

At simultaneous administration ACC with vasodilators and nitroglycerin may enhance the vasodilator effect.

There is a synergism between acetylcysteine ​​and bronchodilators.

ACC is pharmaceutically incompatible with antibiotics (penicillins, cephalosporins, erythromycin, tetracycline and amphotericin B) and proteolytic enzymes.

Acetylcysteine ​​reduces the absorption of cephalosporins, penicillins and tetracycline, so they should be taken orally no earlier than 2 hours after taking acetylcysteine.

When acetylcysteine ​​comes into contact with metals and rubber, sulfides with a characteristic odor are formed.

Analogues of the drug ACC

Structural analogues of the active substance:

• N-AC-ratiopharm;
• N-acetylcysteine;
• Acestine;
• Acetylcysteine;
• Acetylcysteine ​​SEDICO;
• Acetylcysteine ​​solution for inhalation 20%;
• Acetylcysteine ​​solution for injection 10%;
• Mukobene;
• Mucomist;
• Mukonex;
• N-AC-ratiopharm;
• Fluimucil;
• Exomyuk 200.

If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.

Effective and inexpensive analogues-substitutes Acc

ACC treats lesions of the respiratory tract that are complicated by difficult sputum separation, such as bronchitis, tracheitis, pneumonia. Original remedy based on Acetylcysteine ​​is quite popular due to its high efficiency. However, the drug is no exception to the rule, and it also has a number of cheap analogues, like many other drugs. Below we will talk about such substitutes and individual characteristics specific positions.

The essence of the action

The distinctive properties of the drug ACC are determined by substance Acetylcysteine, which acts against cough as follows:

• Mucolytic. In other words, it reduces the viscosity of sputum, which further accelerates the process of its removal.
• Reduces ability bacterial cells to adhesion, or adhesion to the mucous layer of the bronchi.
• Antioxidant properties help neutralize the harmful effect of free particles, which, when entering the lungs with air, can be provocateurs of the disease.
• Anti-inflammatory the effect is observed due to the elimination of pathogenic factors (microbes, toxins) through antioxidant activity.

What does the drug treat?

Indications for use:

The drug is used for diseases of the respiratory tract, affecting both the upper and lower section. The main point that unites all the indications of the pharmaceutical product is the presence of sputum formation, which, due to its thick, viscous consistency, does not drain well, which further forms an abundant accumulation of mucous secretion in the bronchi.

Some of the indications with characteristic hard-to-clear sputum:

• Bronchitis acute, chronic, obstructive;
• Inflammation of the trachea, laryngotracheitis;
• Bronchial asthma;
• Bronchiectactic disease;
• Pneumonia, lung abscess;
• Pulmonary obstructive disease (COPD);
• Bronchiolitis, cystic fibrosis;
• Sinusitis, otitis media.

The benefits of the medicine for the above chronic diseases are noticeable in reducing the severity and frequency of exacerbations, with acute forms- the onset of recovery is accelerated.

It is noteworthy that the mucolytic qualities of ACC similarly extend to purulent-exudative processes.

Contraindications

• The appearance of bloody spots in expectorated mucus;
• Pulmonary hemorrhages;
• Exacerbation of stomach and duodenal ulcers;
• Pregnant and breastfeeding women;
• Personal intolerance to Acetylcysteine. This is indicated by itching, headache, and runny nose of non-inflammatory origin.

ACC, dosed at 100 and 200 mg, is prohibited for children under 2 years of age. The enhanced dosage form of 600 mg is dangerous for children under 14 years of age.

Possible negative effects

IN in rare cases can be: nausea, vomiting, heartburn, skin rashes and itching.

Patients with liver or kidney failure require more gentle therapy with this mucolytic, because most of the metabolic transformations are carried out by the liver, and primary excretion from the body is carried out by the kidneys.

Important instructions for use

All forms of ACC are used orally after meals. The duration of treatment depends on individual needs, but for colds it most often lasts 5-7 days. It is advised to avoid taking it immediately before going to bed and take it last before 18.00. When using antibiotics simultaneously with a pharmaceutical drug, a break between their consumption of 1-2 hours is necessary.

Introductory instructions for use:

• Standard method Taking the drug for adults and children over 14 years of age is: 200 mg in 2-3 approaches per day.
• Children from 6 to 14 years old 100 mg 2-3 per day is indicated.
• For ages 2 to 6 years 1 effervescent tablet of 100 mg is recommended once a day. If it is syrup or soluble granules 100 mg, take it 2-3 times a day.
• If there is very severe cough The recommended dosage is 600 mg, which should not be taken more than once a day.
• If you are using a syringe dispenser, attached to baby syrup, it must be washed each time with clean water at the end of use.
• Effervescent tablets must be used immediately after preparing the solution .
• Granules can be diluted with water, juice or tea drink.

An additional therapeutic measure that accelerates the healing process is to increase the volume of fluid consumed, which has a positive effect on the mucolytic dynamics of the expectorant.

How much does ACC cost: price in pharmacies

The cost of German medicine starts from 120 rubles. and reaches 600 rubles. Any drug in the line can be purchased without a prescription.

List of synonyms of Russian and foreign production

The table contains examples of analogues of various dosage forms. The indicated absence of some items is meant at the time of writing only on designated pharmacy web resources, but does not indicate a shortage of a particular drug in pharmacies throughout the country as a whole, including in the regions of Moscow and St. Petersburg.

Rinofluimucil (Italy)

The only one of the listed analogues used externally. The spray can replace internal medications if you have rhinitis with thick mucus.

Espa-naz (Germany)

Generic available High Quality. Mucolytic orange flavor provides expectorant effect on productive cough, inhibiting the accumulation of mucus in the bronchi and facilitating its unhindered discharge.

Fluimucil (Italy)

A European synonym with a lower cost, while maintaining compliance with quality requirements.

Regarding the timely use of Fluimucil for cough, a number of experts note its benefits, which can be traced to a reduction in the need for antibacterial therapy. There is also a significant reduction in the severity of inflammation, which in turn prevents complications. There is an obvious decline in general intoxication, which is greatly facilitated by antioxidant properties included in Acetylcysteine.

Thoraxol Solution Tablets (Russia)

Domestic relatively inexpensive substitute of interest modern form dispersible tablet. Relief of cough associated with the formation of viscous sputum, either acute or chronic, occurs by stimulating the activity of the ciliated membrane of the bronchi and by reducing the viscosity of mucous formations. All this together creates conditions for faster spontaneous cleansing of the surface of the mucous layer.

It is worth considering that Thoraxol only works in the presence of lesions in the lower part of the respiratory system: bronchitis, obstructive disease, pneumonia.

The active substance does not lose its mucolytic qualities regardless of the method of administration, and there are several of them:

1. Split the tablet in half and drink the whole tablet without water.. Once in the stomach, it quickly begins to dissolve. This method is convenient if you do not have time to prepare a portion of the medicine.
2. Dissolve in 20 ml of water, then immediately take the resulting suspension.
3. Drink a whole one with a small portion of water.

Lactation and the first three months of pregnancy are the main contraindications for Thoraxol.

Neo-bronchol (Germany)

Cheaper expectorant tablets, the main ones the advantages of which are:

• Lack of sugar (sorbitol serves as a sweetener);
• The type of dosage form intended exclusively for resorption does not require any additional manipulations.

The drug acts within the first half hour after administration and continues to reveal mucolytic activity after 6-12 hours.

In rare situations unwanted impact Neo-bronchola is expressed skin reactions and stomach upset.

Ambroxol (RF)

An inexpensive way to cope with difficult things wet cough. The description of the pharmacological route of action of Ambroxol has already been mentioned above. The types of dosage forms produced by Russian companies are varied: syrups, regular tablets, solutions. Tablets cost the least, But greatest attention attracts solution for inhalation as the most modern method mucolytic therapy .

Some of the advantages of the inhalation route of administration of Ambroxol:

• Rapid access to the site of inflammation;
• A comfortable level of hydration of the respiratory organs, namely the bronchial mucosa, is achieved;
• The natural physiological outflow of mucus and its dilution are improved.

Taken together, these factors significantly accelerate the process of onset of the therapeutic effect.

Bromhexine is the cheapest alternative from Germany

The main goal of Bromhexine is to eliminate the high coefficient of mucus thickness, which for this reason does not clear well and causes a cough reflex.

Interestingly, after the biotransformation of Bromhexine in the liver, the active metabolite Ambroxol is formed. It is he who ultimately determines all its properties.

Conclusions on available replacements

Cough treatment expectorant group It is unacceptable to combine it with an antitussive, otherwise the suppression of the cough reflex by the latter will lead to the opposite effect - difficulties will be created in removing accumulated mucus from the bronchi. In any case, the correct selection of treatment should take place with the participation of a doctor in order to promptly identify hidden, sluggish symptoms of the disease, thereby avoiding overflow acute condition into chronic.

Cough is the main symptom of most colds. It is a reflex act accompanied by a sharp contraction of the respiratory muscles and subsequent release of air. The reflex is aimed at eliminating the irritant from the trachea and bronchi. Painful cough causes discomfort, so during the treatment of a cold, antitussive drugs are prescribed. They not only alleviate the condition, but also improve sputum production - making the cough productive.

“ACC” is extremely popular, which is actively used to treat diseases accompanied by cough. The drug contains acetylcysteine ​​- it is the active ingredient. The medicine is available in the form of tablets, granules, and syrup is well suited for children.

The powder costs 150-200 rubles, and effervescent tablets cost 270.

Action

Acetylcysteine ​​affects the secretions of the bronchi and sinuses, breaking the bonds formed between mucopolysaccharide molecules. This helps to thin the mucus, thereby improving the cleansing of the respiratory tract. At the same time, the cough becomes wet, and it is easier for patients to tolerate than a painful dry one. In the sinuses of the nose, liquefaction of secretions also occurs. The additional anti-inflammatory effect is due to the activation of immune cells. The active substance has high bioavailability; after 2 hours the maximum possible concentration is observed in the blood.

Indications

The medicine is effective for treating conditions accompanied by increased secretion production. These include respiratory tract diseases - bronchitis and bronchiolitis, tracheitis, asthma. It is also effective for the treatment of sinusitis and exudative otitis. Positive result observed when taken for the treatment of cystic fibrosis and laryngitis. This drug and similar drugs have such indications - often the ACC analogue is cheaper.

Instructions for use

The drug is prescribed after meals. Granules or effervescent tablets should be dissolved in warm water- 100 ml. Daily dosage for children over 14 years of age and adults is 400-600 mg. It should be divided into 2 or 3 doses. For children 6-12 years old, 300-400 mg/day is prescribed, and for children 2-5 years old - 200-300 mg/day. The drug is also used to treat children over 10 years of age - 50 mg per day. The dosage is adjusted by the attending physician. As a rule, treatment is carried out for 7 days, but sometimes the course is increased.

Side effect

The drug has a small number of side effects. ACC can cause nausea, vomiting and heartburn. From the outside nervous system Possible tinnitus and headache. In addition, there are cases of increased blood pressure after using the medicine.

Contraindications

The medicine "ACC" can be used by both adults and children. In what cases should it not be prescribed? The drug is contraindicated if there are:

• allergies to components and fructose intolerance;
• pulmonary hemorrhage;
• peptic ulcer;
• renal and liver failure severe.

How to replace "ACC"?

The drug is effective for treating cough. It improves mucus discharge, making cough productive and less painful. Accelerated removal of mucus from the respiratory tract is the key to rapid successful treatment. However, many are interested in whether there is a cheaper analogue of “ACC”.

"Abrol"

The active substance of the drug promotes the activation of serous cells in the bronchial glands, and also increases the formation of special enzymes responsible for the breakdown of sputum mucopolysaccharides. The drug is characterized by a pronounced expectorant effect, which makes it a worthy replacement for ACC. "Abrol" tablets are suitable for the treatment of adults and children over 12 years of age. As a rule, the doctor prescribes a course of 1 tablet 3 times a day. The effect occurs already in the first week. In some cases, treatment is extended to 2 weeks. "Abrol" syrup can be used in childhood due to its more convenient release form. The drug can be taken from 1 year. The medicine is usually well tolerated by patients, and the number of side effects is less than that of ACC. If intolerance occurs, development may occur allergic reaction in the form of urticaria, which is characterized by skin rashes and itching. This is an indication for discontinuation of the drug. Dyspepsia is very rare, and no central nervous system symptoms were observed. Like its analogue, Abrol is not recommended in the first trimester of pregnancy, and in subsequent trimesters only with the permission of a doctor. The cost of tablets is 100-150 rubles.

"Lazolvan": price and features

The medicine is a clear or brownish solution that is used orally or for inhalation. The active ingredient is the same as that of Abrol. The drug helps increase secretion and increases ciliary activity. It is contraindicated in case of intolerance, lactation and in the first trimester of pregnancy (2nd and 3rd - with caution under medical supervision). Ambroxol has the ability to penetrate the placental barrier, but its direct effect on the fetus has not been proven. However, it is recommended to use it during this period only under strict indications. The peculiarity of the drug is that side effect, as a violation of taste perception, but it occurs quite rarely. The advantage of the drug is the absence of unwanted drug interactions. It can enhance the penetration of amoxicillin, erythromycin and cefuroxin into the bronchial secretions. More and more often, experts recommend Lazolvan. The price for it is 200-220 rubles.

"Fluimucil"

The active ingredient is acetylcysteine, like ACC. The drug is available in the form of tablets and injections, which allows it to be used parenterally. The medicine is administered intramuscularly or intravenously. This provides a significant increase in bioavailability, since the drug penetrates directly into the blood, bypassing the gastrointestinal tract. Due to high tolerance to acetylcysteine, long courses of treatment are allowed. Contraindications are identical to “ACC”, and the list of indications is supplemented by pneumonia and cystic. Effervescent tablets contain aspartame, so this form is contraindicated in patients suffering from phenylketonuria. Effervescent tablets are sold at a price of 150-170 rubles, solution - 120 rubles.

"Mukaltin"

This is a drug plant origin, since it contains polysaccharides from marshmallow. This analogue of “ACC” is cheaper than other drugs. Extract medicinal root promotes stimulation ciliated epithelium, resulting in increased secretion and improved sputum production. The drug is non-toxic and does not have any irritating effect. You should not take the medicine if you have allergies, as well as peptic ulcers and gastritis. Due to the presence of polysaccharides, it is prescribed to patients with caution. diabetes mellitus. "Fluimucil" or "Mukaltin" are a worthy replacement for "ACC". Price - 20-30 rubles.

"Mukosol"

An effective medicine based on carbocisteine. The action is based on the activation of sialic transferase, which is an enzyme concentrated in the bronchial mucosa. Due to the stabilization of sialomucins and a decrease in the amount of glycopeptides, the viscosity of sputum decreases. It separates better, and the cough becomes less intense. Thanks to the secretion of immunoglobulin A, an increase occurs. A special feature is that the active substance of the drug does not have an irritating effect on the mucous membrane gastrointestinal tract. “Mukosol” syrup is prescribed for pathologies of the bronchopulmonary system, as well as for sinusitis. It should not be used if you have allergies, phenylketonuria (if aspartate is present), pregnancy, or renal failure. The granules are also contraindicated for use by children under 12 years of age. Carbocisteine ​​often causes side effects such as nausea, pain in epigastric region and diarrhea. Cost - 150-190 rubles.

"Bromhexine"

The expectorant effect is explained by the depolymerization of mucopolysaccharide molecules. In addition, the drug activates the production of surfactant, which increases the stability of alveolar cells. All this helps to protect the respiratory tract and improve the rheology of bronchial secretions. The drug is used not only for bronchitis, asthma and bronchiectasis, but also for pneumonia, tuberculosis and emphysema. Contraindications include intolerance, pregnancy and lactation, as well as peptic ulcer. In addition, it is not recommended for patients with renal failure And stomach bleeding. Bromhexine-Acri may cause side effects (nausea, headache, dyspepsia). When an allergic reaction occurs, skin rashes usually occur. Less common are rhinitis and the price of tablets is about 150 rubles.

Antitussive drugs can significantly improve the patient's condition and speed up recovery. For this, acetylcysteine ​​and the ACC analogue can be used. It is cheaper to purchase analogues, but before doing so you should consult your doctor. Any medication use requires consultation with a specialist.