Inflammatory diseases of the gastrointestinal tract are widespread due to poor nutrition and unhealthy lifestyle. Maintain the body in good condition and the drug Ranitidine helps prevent gastrointestinal lesions.
The drug in tablets Ranitidine belongs to the group of antiulcer drugs for the treatment and prevention of lesions of the gastrointestinal tract. Its basis is the component ranitidine hydrochloride, which reduces acidity in the stomach for a long time, suppressing the production of hydrochloric acid V digestive system and increasing pH. The tablets have a white or orange shell (color depends on the manufacturer) and are available in standard cardboard boxes.
For complete treatment of the digestive system, the drug is used in courses. When used once, the duration of action of the medicine is 12 hours. The maximum concentration of the substance in the body is observed within two hours after administration. The components of the drug are removed primarily through the kidneys.
The medicine is sold through pharmacy chains without a doctor's prescription. Information about how much packaging costs in a specific region must be clarified locally. The average price is 20-50 rubles.
Ranitidine tablets are prescribed for the treatment and prevention of inflammatory diseases digestive organs chronic and acute form. The drug is used primarily as part of complex therapy. Main indications:
The drug can be used for surgical intervention as a prophylactic against reflux gastric juice into the respiratory tract.
The tablets must be taken regardless of the meal plan, washed down with a small amount clean water. The dosage for each disease is determined by the attending physician. Standard dosing is as follows:
Many patients are interested in the question of how much better Ranitidine is than herbal teas and cheaper or more expensive analogues. These drugs have similar properties and indications for use. But the decision to choose a drug is based on individual characteristics patient and carried out by the attending physician.
The drug should not be taken by pregnant and lactating women, as well as children under 12 years of age. Other restrictions:
During the course of therapy, it is not recommended to smoke or drink alcohol, as this reduces the effectiveness of taking the medication. If necessary joint use Ranitidine with other drugs requires consultation with your doctor. As a rule, the intervals between medications should be at least two hours.
At hypersensitivity Allergic reactions to the composition are possible. In this case, anaphylactic shock, bronchospasm, urticaria and others occur. dermatological lesions. Other possible side effects and complications:
Most often, side effects occur in elderly patients, so their treatment should be under the supervision of a doctor. If you have respiratory tract diseases, you should consult your doctor before using the medicine.
In case of overdose, bradycardia, arrhythmia, and changes in blood pressure are possible.
Increased side effects are also likely. Treatment in this case is symptomatic. If allergic reactions occur, stop using Ranitidine and consult a doctor.
There are similar drugs based on their composition, principle of action, and therapeutic effect.
| Name of the medicine | Main component of the composition | Short description | Cost of packaging in Russia (rubles) |
| Famotidine | The drug is available in powder form for injection and tablets. The main direction is the treatment and prevention of ulcers and inflammation of the gastrointestinal tract | 80-100 | |
| Cimetidine | Cimetidine | A drug against ulcerative lesions and inflammatory diseases of the digestive system | 100-200 |
| Famotidine | Famotidine | Antiulcer medication, helps prevent and eliminate inflammatory lesions | 10-50 |
| Gastrosidin | Famotidine | Antiulcer drug for preventive and therapeutic purposes | 300-400 |
Instructions for use
Attention! The information is provided for informational purposes only. This instruction should not be used as a guide to self-medication. The need for prescription, methods and doses of the drug are determined exclusively by the attending physician.
international and chemical names : ranitidine, N--2-furanyl]methyl]thio]ethyl]-N'-methyl-2-nitro-1,1-ethylenediamine, hydrochloride;
basic physical and chemical properties: film-coated tablets, yellow to orange-yellow in color, with a specific odor. The cross section shows two layers;
compound: 1 tablet contains ranitidine hydrochloride equivalent to ranitidine 150 mg;
Excipients: cellactose, croscarmellose sodium, colloidal anhydrous silicon dioxide (Aerosil), magnesium stearate, hypromellose (hydroxypropyl methylcellulose), titanium dioxide, tropeolin 0.
Release form. Film-coated tablets.
Medicines for the treatment of peptic ulcers and gastroesophageal reflux disease. ATS code A02B A02.
Pharmacodynamics. Antiulcer agent. Blocks histamine H2- receptors (Receptor(Latin receptio - perception, English receptor): 1) specific sensitive formations in living organisms that perceive external and internal stimuli (extero- and interoreceptors, respectively) and transform the activity of the nervous system. Depending on the type of perceived irritation, there are mechanoreceptors, chemoreceptors, photoreceptors, electroreceptors, thermoreceptors\; 2) active groups of protein macromolecules with which mediators or hormones, as well as many drugs, specifically interact. A receptor is a conformationally mobile macromolecule or set of macromolecules, the binding of a ligand (agonist or antagonist) to which causes biological or pharmacological effects. A number of receptors exist in several subtypes. There are four main types of receptors: 1) membrane receptors associated with ion channels and consisting of several protein subunits that are located in the biological membranes of cells in a radial order, forming ion channels(eg, H-cholinergic receptors, GABA A receptors, glutamate receptors)\; 2) membrane receptors coupled to G-proteins, consisting of protein molecules that “stitch” biological membranes seven times\; the biological effect upon activation of these receptors develops with the participation of a system of secondary transmitters (Ca2+ ions, cAMP, inositol-1,4,5-triphosphate, diacylglycerol). Receptors of this type are available for a number of hormones and mediators (for example, M-cholinergic receptors, adrenergic receptors, etc.)\; 3) intracellular or nuclear receptors that regulate DNA transcription processes and, accordingly, protein synthesis by cells. They are cytosolic and nuclear proteins (for example, receptors for steroid and thyroid hormones)\; 4) membrane receptors that directly control the functions of the effector enzyme, associated with tyrosine kinase and regulating protein phosphorylation (for example, insulin receptors, a number of growth factors, etc.)) membranes of parietal cells of the gastric mucosa. Reduces basal and stimulated secretion of hydrochloric acid, reducing the volume of gastric juice caused by irritation of baroreceptors (gastric distension), food load, action hormones (Hormones- biologically active substances produced in the body by specialized cells or organs (glands) internal secretion) and have a targeted effect on the activity of other organs and tissues) and biogenic stimulants (gastrin, histamine (Histamine- a derivative of the amino acid histidine. Contained in inactive, bound form in various organs and tissues, is released in significant quantities during allergic reactions, shock, burns. Causes dilation of blood vessels, contraction of smooth muscles, increased secretion of hydrochloric acid in the stomach, etc.), pentagastrin, caffeine). Ranitidine reduces the amount of hydrochloric acid in gastric juice, does not inhibit cytochrome P 450, does not affect the concentration of gastrin in plasma (Plasma- the liquid part of the blood that contains shaped elements(erythrocytes, leukocytes, platelets). Various diseases (rheumatism, diabetes etc.). Medicines are prepared from blood plasma) blood, as well as mucus production.
Pharmacokinetics. At orally (Orally- route of administration of the drug through the mouth (per os)) When taken, it is quickly absorbed into the gastrointestinal tract. The maximum concentration in the blood is 478 ng/ml when taken orally and is achieved after 2–3 hours. Partially metabolized in the liver to N-oxide (the main metabolite, 4% of the dose), S-oxide and demethylated.
Half-life (Half-life(T1/2, synonymous with half-elimination period) - the period of time during which the concentration of a drug in the blood plasma decreases by 50% from the initial level. Information about this pharmacokinetic indicator is necessary to prevent the creation of a toxic or, conversely, ineffective level (concentration) of the drug in the blood when determining the intervals between administrations) under normal conditions creatinine clearance (Creatinine clearance- an indicator characterizing the glomerular filtration rate. The level of creatinine in the blood is used to assess the efficiency of the kidneys. Creatinine clearance is the volume of blood plasma that is cleared of creatinine in 1 minute when passing through the kidneys)(after oral administration) – 2-3 hours; at reduced levels (20-30 ml/min) – 8–9 hours. Excreted by the kidneys after 24 hours, about 30% of the orally administered dose is excreted unchanged.
Penetrates through histohematic barriers, including through the placental, but poorly through blood-brain barrier (Blood-brain barrier- a barrier formed by the endothelium of brain vessels: between endothelial cells there are no intercellular spaces characteristic of other vessels. As a result, water-soluble polar substances do not penetrate into the brain from the blood). Enough significant concentrations detected in breast milk. The rate and extent of elimination depend little on the condition of the liver and are mainly related to kidney function.
Peptic ulcer and duodenum (Duodenum - primary department small intestine(from the gastric outlet to the jejunum). Length duodenum human equal to the diameter of 12 fingers (hence the name)); gastroesophageal reflux disease (GERD); chronic (Chronic- long-lasting, incessant, protracted process occurring either continuously or with periodic improvements) gastritis (Gastritis- a disease manifested by inflammation of the mucous membrane of the stomach wall) with increased acid-forming function of the stomach in the acute stage, non-ulcer dyspepsia (Dyspepsia– digestive disorder resulting from a lack of enzymes or as a result of poor nutrition); Zollinger-Ellison syndrome.
Adults take orally, without chewing, with a small amount of water.
Peptic ulcer of the stomach - 150 mg (1 tablet) 2 times a day or 300 mg (2 tablets) at night for 4-8 weeks.
Peptic ulcer of the duodenum - 1 tablet 2 times a day or 2 tablets 1 time at night for 4-6 weeks.
Gastroesophageal reflux disease (GERD) – 150 mg 4 times a day for 4–8 weeks. Supportive therapy (Therapy- 1. The field of medicine that studies internal illnesses, one of the oldest and main medical specialties. 2. Part of a word or phrase used to indicate the type of treatment (oxygen therapy\; hemotherapy - treatment with blood products)) for GERD – 1 tablet 1 time per day. The course of treatment is up to 12 weeks.
Zollinger-Ellison syndrome - initial dose 150 mg 4 times a day. If necessary, the dose is increased. Dose selection is individual.
For non-ulcer dyspepsia - 1 tablet 2 times a day for 2-4 weeks.
Chronic gastritis with increased acid-forming function of the stomach in the acute stage - 2 tablets per day for 2-4 weeks.
Patients with impaired renal function require dosage adjustment. At ground clearance (Clearance(purification, purification) - a pharmacokinetic parameter reflecting the rate of purification of the blood plasma from the drug and denoted by the symbol C1) creatinine less than 50 ml/min – 150 mg/day.
Patients who are on hemodialysis (Hemodialysis- a method of extrarenal blood purification for acute and chronic renal failure. During hemodialysis, toxic metabolic products are removed from the body, disturbances in water and electrolyte balance are normalized), the next dose is prescribed immediately after the end of hemodialysis.
Use in children over 12 years of age is recommended when indicated and in dosages corresponding to adults.
Rarely: headache, dizziness, drowsiness, anxiety, agitation, depression (Depression - mental disorder: sad, depressed mood with pessimism, monotony of ideas, decreased motivation, retardation of movements, various somatic disorders), hallucinations (Hallucinations- these are perception disorders in which objects or phenomena are found where in reality there is nothing)(mainly in seriously ill and elderly patients), reversible blurred vision, involuntary movements; arrhythmias (Arrhythmia- disturbance of normal heart rhythm. Arrhythmia manifests itself in an increase in heart rate (tachycardia) or slowdown (bradycardia), in the appearance of premature or additional contractions (extrasystole), in attacks of palpitations ( paroxysmal tachycardia), in complete irregularity of the intervals between individual heart contractions (atrial fibrillation)) (extrasystole (Extrasystole- violation heart rate, characterized by premature contraction of the entire heart or its individual parts), tachycardia (Tachycardia- increase in heart rate to 100 or more beats per minute. Occurs during physical and nervous tension, diseases of the cardiovascular and nervous systems, diseases of the endocrine glands, etc.), AV- blockade (Blockade- slowing down or interrupting the conduction of electrical impulses in any part of the conduction system of the heart or myocardium), bradycardia (Bradycardia– a decrease in the number of heart contractions to 60 beats per minute or less (absolute bradycardia) or a lag between the increase in heart rate and the increase in body temperature), asystole (Asystole- disruption of the functioning of all parts of the heart or one of them with myocardial depression and cardiac arrest)); constipation, diarrhea (Diarrhea- frequent discharge of liquid feces associated with accelerated passage of intestinal contents due to increased peristalsis, impaired absorption of water in the large intestine and excretion by the intestinal wall significant amount inflammatory secretion), nausea, vomiting, abdominal pain; cholestatic or mixed hepatitis c (Hepatitis C– viral infection, manifested by damage to hepatocytes, with parenteral transmission) jaundice (Jaundice - painful condition, characterized by the accumulation of bilirubin in the blood and its deposition in tissues with staining yellow skin, mucous membranes, sclera of the eyes. Observed when increased decay red blood cells (eg, neonatal jaundice, jaundice due to hemolytic anemia), viral hepatitis and other liver diseases, obstruction of bile outflow) or without it; arthralgia and myalgia (Myalgia- muscle pain caused by spasm, compression, inflammation or muscle ischemia); increased creatinine in the blood; leukopenia (Leukopenia- the content of leukocytes in the peripheral blood is less than 4000 in 1 μl, due to the influence of various damaging factors on the body), granulocytopenia, agranulocytosis (Agranulocytosis– a pathological syndrome in which the number of granulocytes in the peripheral blood sharply decreases or they are completely absent), pancytopenia (Pancytopenia- a marked decrease in the number of red blood cells, all types of leukocytes and blood platelets in the circulating blood), bone marrow hypoplasia and aplastic anemia (Aplastic anemia– anemia associated with the absence or deficiency of function spinal cord) ; gynecomastia (Gynecomastia- development of mammary glands in a man according to the female type with some endocrine diseases And How adverse reaction for some medicines), impotence, decrease libido (Libido - sexual desire) ; alopecia (Alopecia– increased hair loss and insufficient new growth), rash, erythema multiforme, angioedema (Angioedema- (Quincke's edema), acute limited paroxysmal swelling of tissues. Quincke's edema is the body's reaction to an allergen. Externally, Quincke's edema manifests itself as sharply limited swelling of tissues (mainly lips, eyelids, cheeks), sometimes skin rashes at the site of swelling, usually without itching or pain), anaphylaxis.
Hypersensitivity (Hypersensitivity- increased response of the patient to the usual dose of the drug), liver cirrhosis with portosystemic encephalopathy (Encephalopathy- a collective term denoting organic brain damage of a non-inflammatory nature. There are congenital encephalopathy - as a result of embryopathy, and acquired - as a result of infections, intoxications, injuries, vascular diseases brain, etc. There are no specific manifestations of encephalopathy\; Neurosis-like (asthenia, irritability, insomnia, headache) and (or) psychopath-like (narrowing of the range of interests, passivity, emotional incontinence, rudeness, etc.) disorders, memory and intellectual impairments may come to the fore. V medical history (Anamnesis- a set of information about the development of the disease, living conditions, previous diseases etc., collected for the purpose of use for diagnosis, prognosis, treatment, prevention); pregnancy, lactation (Lactation- secretion of milk from the mammary gland)(Breastfeeding is stopped during the treatment period).
An overdose is accompanied by increased side effects of the drug.
Treatment: induction of vomiting or gastric lavage, for convulsions - diazepam intravenously, for bradycardia - atropine, for ventricular arrhythmias - lidocaine.
Use with caution to treat patients with impaired renal function, with porphyria (history). Before starting treatment, the presence of malignant neoplasms in the stomach and duodenum should be excluded.
In elderly patients with impaired liver or kidney function, a disorder (confusion) of consciousness may occur, necessitating a dose reduction.
It is not advisable to suddenly stop the drug ( rebound syndrome (Rebound syndrome- exacerbation of symptoms of the disease with abrupt cessation of use medicinal substance. The withdrawal syndrome that occurs with long-term use of beta-blockers is the result of an increase in the density of beta1-adrenergic receptors\; manifested by angina pectoris, arrhythmia, hypertensive crisis. Withdrawal syndrome that occurs when long-term use clonidine, manifests itself as a hypertensive crisis\; with long-term use of extrasynaptic alpha2-adrenergic agonists (naphazoline) - nasal congestion (medicinal rhinitis). Stop medications causing the syndrome cancellations? it is necessary gradually\; substances that cause rhinitis are used for a short time (several days))). After reaching therapeutic effect the drug must be taken in a maintenance dose for 1-4 weeks.
Regular monitoring of patients (especially elderly patients and those with a history of peptic ulcer of the stomach and/or duodenum) taking Ranitidine along with non-steroidal anti-inflammatory drugs is necessary.
Transport drivers and people whose work requires precise coordination of movements should take the drug with caution, as it can impair coordination and attention.
Antacids, sucralfate slow down absorption (Absorption- the process by which a drug substance passes from the site of administration to blood vessels)
ranitidine, so the interval between taking them should be at least 2 hours.
Does not depress the liver metabolism (Metabolism- the totality of all types of transformations of substances and energy in the body, ensuring its development, life activity and self-reproduction, as well as its connection with environment and adaptation to changes in external conditions) phenazole, aminophenazole, hexobarbital, propranolol, diazepam, lidocaine, indirect anticoagulants (Anticoagulants- drugs that reduce blood clotting).
Increases the concentration of metoprolol in the blood serum, while the half-life of metoprolol increases.
Reduces the absorption of ketoconazole and itraconazole.
Storage conditions and periods. Store in a dry place, protected from light and out of reach of children, at a temperature not exceeding 25 0C.
Shelf life – 3 years.
Vacation conditions. On prescription.
Package. Film-coated tablets, 150 mg each, No. 10, No. 10x2 in blister packs, in a cardboard pack.
Manufacturer.LLC "Pharmaceutical company "Zdorovye".
Location. 61013, Ukraine, Kharkov, st. Shevchenko, 22.
Website. www.zt.com.ua
This material is presented in free form on the basis of official instructions for medical use drug.
The instructions for use for Ranitidine describe the effect of the drug, dosage, and contraindications for use.
Ranitidine– a pharmaceutical for the treatment of gastrointestinal diseases, which are inherently associated with excessive production of gastric juice.
Produced by enterprises in Russia, Switzerland, Bulgaria, and India.
It has two dosage forms:
There are several types of the drug:
The active component of all of the above products is Ranitidine.
Basics active substance- Ranitidine hydrochloride.
Characteristic:
Basics active substance- Ranitidine hydrochloride.
In addition, the composition includes:
Characteristic:
Instructions for use are included in the packages of tablets and solution.
Ranitidine is a remedy against ulcerative and erosive lesions of the gastrointestinal tract, a therapeutic and supportive agent. The second antisecretory drug, after cimetidine, that has successfully passed clinical trials.
The instructions for use of the drug describe in detail its therapeutic effect, pharmacodynamics and pharmacokinetics.
The antisecretory effect of Ranitidine ensures healing of ulcers in gastrointestinal tract, increases the amount of mucus, improves the flow of blood, lymph, interstitial fluid through microvessels and intercellular spaces.
Thanks to its restorative effect, regeneration processes are launched at the cellular level.
Blocks H2 histamine receptors on stomach cells that secrete acid.
Ranitidine reduces the amount of hydrochloric acid contained in gastric juice and the juice itself. The result is a decrease in the activity of enzymes, including pepsin.
The duration of action of the drug after a single dose is 10 hours or more.
Absorption is quite high. After administration, the main component is quickly and almost “without loss” absorbed into the blood, and from the blood enters the mucous membranes of the gastrointestinal tract. It does not matter whether the drug was taken before or after a meal.
Maximum bioavailability 50%. 60 minutes for effervescent tablets and less than 3 hours for regular tablets are enough for the effect of the drug to reach its climax. Metabolic processes start and take place in the hepatic zone. The condition of the liver is the main factor in removing the drug from the body.
The removal of the drug from the body is controlled by the urinary system. 30% of the drug leaves the body unchanged.
A small amount leaves the body in the feces.
Placental obstruction is not a guaranteed protection of the fetus from the effects of the drug; its ability to penetrate into mother's milk and be excreted with it is noted.
BBB (dividing line between the circulatory and central nervous systems,) is difficult to overcome and serves as a significant obstacle.
It is used as a therapeutic, prophylactic and supportive agent for gastrointestinal lesions of various nature and nature:
The use of the drug is most justified for ulcerative processes in the stomach and intestines; any kind dyspeptic disorders: heartburn, pain in the stomach, belching.
The instructions describe in detail the contraindications to the use of the drug:
The annotation describes the dosages, time and number of doses:
For any type of pathology, individual adjustment of the dose of the prescribed drug is possible.
Application of the solution:
The annotation indicates the age limit for use - 14 years.
Today, the industry produces drugs with a more gentle effect.
Ranitidine is a drug that affects the mucous membrane and reduces acidity.
The final formation of the esophagus and its muscular membrane ends by 12-14 years.
Only a qualified specialist can prescribe Ranitidine to a child. The indications are no different from those for adult patients.
Taking tablets and administering the drug by injection is possible from the age of 14.
Stories from our readers!
“I was diagnosed with pancreatitis about 1.5 years ago. One day at work, the pain was so severe that my colleagues called the ambulance. The paramedic who arrived immediately suggested acute pancreatitis. His diagnosis was confirmed by tests. The therapist recommended changing my diet.
Despite my efforts to stick to the diet, after 4 months the disease still made itself felt. I decided to order a monastery collection of herbs for pancreatitis via the Internet. For three weeks I regularly drank monastery herbal tea, then sometimes used it instead of tea in the morning or evening. Six months have passed since that moment, I have not had a single attack of the disease."
No clinical studies have been conducted on the safety of the drug during pregnancy. But the ability of Ranitidine to overcome the protective barriers of the placenta and be excreted in breast milk has been reliably established.
If the use of the drug is necessary during lactation, other means are selected or breastfeeding is stopped.
The body systems respond differently to the administration of the drug, resulting in adverse reactions:
How side effects arise allergic reactions in the form of skin rashes, urticaria, spastic phenomena, Quincke's edema.
The instructions indicate the following symptoms of a drug overdose:
Elimination of overdose manifestations is carried out in conditions medical institution. As a first aid measure, vomiting is induced, the stomach is washed and activated charcoal is given.
Inpatient treatment includes drip infusion the following medications: lidokine, diazepam, atropine.
The instructions indicate unwanted reactions when interacting with Ranitidine with procainamide and its analogues.
Excretion of the latter in urine is difficult, and there is a risk of increasing their mass fraction in plasma.
The abstract notes the interaction of Ranitidine with some drugs of the benzodiazepine class, antihypertensive and antiepileptic drugs.
The instructions for use indicate the incompatibility of Ranitidine with alcohol. The drug interacts with strong alcoholic drinks, beer, champagne.
Taking Ranitidine with alcohol is dangerous for men and women.
Under no circumstances is it possible to use Ranitidine together and drink alcohol during pregnancy and breastfeeding.
If Ranitidine was used as a course, at least 14 days must pass for safe reception alcohol.
The following are considered consequences of the combined use of medicine and alcohol: cardiac arrhythmias, acute heart failure, fainting.
The annotation and instructions indicate caution in the use of Ranitidine in relation to patients suffering from liver pathologies associated with damage to its tissues: liver cirrhosis, portosystemic or hepatic encephalopathy, acute liver failure.
If the use of Rantidin is necessary due to life conditions, its dose is reduced.
Caution is required when using Ranitidine in case of renal dysfunction, acute severe renal failure, and disturbances in water, nitrogen, and electrolyte balance.
Confusion has been observed in patients with renal impairment when using ranitidine. and altered consciousness, it required a reduction in its dose.
In modern medical practice It is possible to use Ranitidine according to living conditions, even in relation to patients undergoing extrarenal blood purification procedures.
Instructions for use for doctors contain special instructions on the use of the drug:
When using the product, do not consume foods that cause increased acidity and irritation of the mucous membranes. During the course of taking Ranitdin, professional activities that require concentration, concentration, and immediate reaction are stopped.
The medicine is excluded from free sale. You can purchase it with a prescription signed by your doctor.
The medication is stored out of the reach of children in its original packaging. During storage, the temperature regime is observed: 15-25 degrees. The storage location must be protected from exposure to sunlight.
The shelf life is indicated on the packaging and in the instructions - 2 years from the date of manufacture. At the end of the period, the medicine is not used.
Inexpensive, low-cost medicine.
Prices vary between 14-60 rubles:
The medication has a number of analogues with similar effects, indications and contraindications:
The following are produced in Russia:
Price fluctuations within 13-63 rubles.
The page contains instructions for use Ranitidine. It is available in various dosage forms of the drug (tablets 150 mg and 300 mg), and also has a number of analogues. This abstract has been verified by experts. Leave your feedback on the use of Ranitidine, which will help other site visitors. The drug is used for various diseases(gastric and duodenal ulcers, heartburn, reflux). The product has a number of side effects and interactions with other substances. Doses of the drug differ for adults and children. There are restrictions on the use of the medicine during pregnancy and breastfeeding. Treatment with Ranitidine should only be prescribed by a qualified physician. The duration of therapy may vary and depends on the specific disease.
Instructions for use and dosage regimen
Ranitidine is taken regardless of meals, without chewing, with a small amount of liquid.
Peptic ulcer of the stomach and duodenum. For the treatment of exacerbations, 150 mg is prescribed 2 times a day (morning and evening) or 300 mg at night. If necessary, 300 mg 2 times a day. The duration of treatment is 4-8 weeks. To prevent exacerbations, 150 mg is prescribed at night, for smoking patients - 300 mg at night.
Ulcers associated with non-steroidal anti-inflammatory drugs (NSAIDs). Prescribe 150 mg 2 times a day or 300 mg at night for 8-12 weeks. Prevention of ulcer formation when taking NSAIDs - 150 mg 2 times a day.
Postoperative and stress ulcers. Prescribe 150 mg 2 times a day for 4-8 weeks.
Erosive reflux esophagitis. Prescribe 150 mg 2 times a day or 300 mg at night. If necessary, the dose can be increased to 150 mg 4 times a day. The course of treatment is 8-12 weeks. Long-term preventive therapy - 150 mg 2 times a day.
Zollinger-Ellison syndrome. The initial dose is 150 mg 3 times a day; if necessary, the dose can be increased.
Prevention of recurrent bleeding. 150 mg 2 times a day.
Prevention of the development of Mendelssohn's syndrome. Prescribed at a dose of 150 mg 2 hours before anesthesia, and preferably 150 mg the night before.
If there is concomitant liver dysfunction, a dose reduction may be necessary.
Patients with renal failure with CC less than 50 ml/min, the recommended dose is 150 mg per day.
Release forms
Film-coated tablets 150 mg and 300 mg.
Ranitidine- blocker of histamine H2 receptors. Reduces basal and stimulated secretion of hydrochloric acid caused by irritation of baroreceptors, food load, the action of hormones and biogenic stimulants (gastrin, histamine, pentagastrin). Ranitidine reduces the volume of gastric juice and the content of hydrochloric acid in it, increases the pH of the stomach contents, which leads to a decrease in pepsin activity. After oral administration in therapeutic doses, it does not affect prolactin levels. Inhibits microsomal enzymes.
Duration of action after a single dose is up to 12 hours.
Pharmacokinetics
Rapidly absorbed; food intake does not affect the degree of absorption. When taken orally, the bioavailability of ranitidine is approximately 50%. Plasma protein binding does not exceed 15%. Slightly metabolized in the liver to form desmethylranitidine and ranitidine S-oxide. It is excreted mainly in urine (60-70%, unchanged - 35%), a small amount is excreted in feces. Penetrates poorly through the blood-brain barrier. Penetrates through the placenta. Excreted in breast milk (the concentration in breast milk in women during lactation is higher than in plasma).
Indications
Contraindications
special instructions
Treatment with ranitidine may mask symptoms associated with gastric carcinoma, so the presence of a cancer-ulcer must be excluded before starting treatment.
Ranitidine, like all H2-histamine blockers, should not be abruptly discontinued (rebound syndrome).
With long-term treatment of weakened patients under stress, it is possible bacterial lesions stomach with subsequent spread of infection.
There is evidence that ranitidine may cause acute attacks porphyria.
H2-receptor blockers should be taken 2 hours after taking itraconazole or ketoconazole to avoid a significant decrease in their absorption.
May cause a false positive reaction to a protein test in the urine.
H2-histamine receptor blockers can counteract the effect of pentagastrin and histamine on the acid-forming function of the stomach, therefore, within 24 hours preceding the test, the use of H2-histamine receptor blockers is not recommended.
Histamine H2 receptor blockers may suppress the skin response to histamine, thus leading to false positive results(before performing diagnostic skin tests to identify allergies skin reaction immediate type, the use of H2-histamine receptor blockers is recommended to be discontinued).
During treatment, you should avoid consuming foods, drinks and other medications that may irritate the gastric mucosa.
Impact on the ability to drive vehicles and operate machinery
During the treatment period, it is necessary to refrain from potentially active activities dangerous species activities that require increased concentration and speed of psychomotor reactions.
Side effect
Drug interactions
Smoking reduces the effectiveness of ranitidine.
Increases the concentration of metoprolol in the blood serum (by 80% and 50%, respectively), while the half-life of metoprolol increases from 4.4 to 6.5 hours.
Due to the increase in pH of the stomach contents with simultaneous administration The absorption of itraconazole and ketoconazole may be reduced.
Inhibits the metabolism in the liver of phenazone, aminophenazone, diazepam, hexobarbital, propracolol, diazepam, lidocaine, phenytoin, theophylline, aminophylline, indirect anticoagulants, glipizide, buformin, metronidazole, calcium antagonists.
Medicines that depress Bone marrow, increase the risk of neutropenia.
When used simultaneously with antacids, sucralfate in high doses the absorption of ranitidine may slow down, so the interval between taking these drugs should be at least 2 hours.
Analogues medicinal product Ranitidine
Structural analogues of the active substance:
Use in children
Contraindicated in children under 12 years of age.
Use during pregnancy and breastfeeding
Ranitidine is contraindicated during pregnancy and lactation.
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