Pimafucin cream for pregnant women. Use during pregnancy and breastfeeding. Active substance and release forms

Often worse during pregnancy chronic diseases or diseases appear that did not bother until that time. The fungus can cause discomfort, as well as affect the well-being of the mother and the health of the unborn baby. Will Pimafucin help in this case and is it safe?

Is Pimafucin harmful during pregnancy

Pimafucin is a topical antibiotic that is indicated for the treatment of fungal diseases of the mucous membranes and skin. According to the instructions, this drug can be used during pregnancy. It is indicated that there are no data on the effect on the fetus. Most often, expectant mothers are prescribed this medicine for thrush, or candidiasis.

Of course, no clinical trials of drugs for pregnant women are carried out, but this drug is considered one of the safest.

Pimafucin can be prescribed by a doctor even in early pregnancy. In the first trimester fungal diseases women are potentially dangerous for the unborn child: there is a possibility of miscarriage or miscarriage. In the II and III trimesters, the infection is fraught with intrauterine infection of the fetus. Also, during childbirth, the baby can become infected with a fungal disease. Therefore, throughout pregnancy, it is important to listen to your condition and start treatment on time if necessary. However, there is another medical opinion.

Thrush is considered physiological norm pregnancy, as increased growth of the fungus is observed in 80-90% of pregnant women. It is not dangerous for both the pregnant woman and the fetus and newborn.

E.P. Berezovskaya
http://www.komarovskiy.net/faq/beremennost-i-molochnica.html

Composition, action and forms of release

The active ingredient in Pimafucin is the antibiotic natamycin. It acts only locally and is not absorbed into the blood. Its content varies depending on the form of release of the drug.

Pimafucin is available in suppositories, tablets and in the form of a cream. With thrush, vaginal suppositories are most often prescribed. If the focus of infection is in the intestines, then the doctor can supplement the treatment regimen with taking pills. Cream in similar cases It is used when a fungus affects the external genital organs of a woman and her sexual partner.

Photo gallery: Pimafucin release forms

Pimafucin tablets are intended for oral administration with intestinal candidiasis Cream Pimafucin has a local antifungal action on the skin and mucous membranes Pimafucin vaginal suppositories are most often prescribed for thrush

What helps: thrush, colpitis and other indications

In most cases, during pregnancy, vaginal candidiasis is treated with Pimafucin, however, the range of application of this local antibiotic is wide, which allows it to be successfully used for other fungal infections. The readings are slightly different for different forms drug release.

Tablets can be prescribed for:

• acute pseudomembranous and atrophic candidiasis;
• otomycosis, external, caused by fungi or complicated by candidiasis;
• skin and nail candidiasis;
• intestinal candidiasis;
• vaginitis (colpitis), vulvitis, vulvovaginitis, balanoposthitis;
• dermatomycosis.

Suppositories are successfully used from:

• vaginitis ();
• vulvitis;
• vulvovaginitis.

The cream can be prescribed in case of:

• vulvitis;
• vulvovaginitis;
• balanoposthitis;
• skin and nail candidiasis;
• otitis externa with candidiasis;
• dermatomycosis.

Despite the safety of the drug, you should not self-medicate. Only a doctor can determine the exact diagnosis and choose suitable shape medications and individual therapy regimen.

Instructions for safe use

Features of the use of candles, tablets and cream

According to the instructions, Pimafucin in candles should be used 1 time per day for 3-6 days. The suppository should be administered at night in the supine position. This is necessary so that the medicine released when the candle melts does not leak out.

The drug in tablets is prescribed 4 times a day. The course usually lasts no more than 1 week. Treatment with tablets can be combined with the use of suppositories and creams.

Usually, after the disappearance of unpleasant symptoms, Pimafucin therapy is continued for several more days to prevent a recurrence of the infection.

The final duration of the course of treatment for all forms of the drug is set by the doctor individually, taking into account the patient's condition.

Contraindications and side effects

Among the direct contraindications in the instructions for Pimafucin, only hypersensitivity to natamycin and auxiliary components drug. Local side effects- irritation of the vagina and a burning sensation - may appear when using Pimafucin in suppositories or in the form of a cream. They are short-term and usually do not require discontinuation of the drug. Tablets have a wider list of side effects:

• nausea,
• diarrhea,

Possible individual reactions associated with intolerance to the components of the drug.

The active substance natamycin does not penetrate the placenta and into the bloodstream that connects the body of the mother and child. Therefore, Pimafucin is considered safe during pregnancy. If any serious side effect still occurs in a woman, then treatment should be stopped, since it is likely that a similar negative effect can happen to the fetus. For example, if a mother has an allergy, then the baby may be born with a tendency to have the same reaction.

What can replace Pimafucin in different trimesters of pregnancy

It also happens that Pimafucin does not help to cope with fungal diseases that bring severe discomfort. Some women note that after a course of treatment with this drug, discharge and other unpleasant symptoms continue to bother them. In this case, it is necessary to consult a doctor and choose another drug that is safe during pregnancy.

Table: Pimafucin analogues, clotrimazole and other antibiotics for the treatment of fungal diseases at different stages of pregnancy

Photo gallery: drugs prescribed for pregnant women with fungal infections

Polygynax is not recommended for use in the first trimester of pregnancy. According to the manufacturer, Nystatin can be taken during pregnancy vaginal tablets Terzhinan can cause mucosal irritation and allergic reactions.
In the first trimester of pregnancy, clotrimazole is not recommended for use. Candide-B6 is not prohibited during pregnancy, but the benefit to the mother and the risk to the fetus should be weighed
Primafungin - pharmacological analogue Pimafucin

Pregnancy is a special period in a woman's life when she has to approach the choice of medicines with the highest responsibility and strictly follow the doctor's recommendations. This principle applies to medicines for all diseases, including those that, it would seem, are "traditional" companions of pregnancy. These common diseases include vaginal candidiasis, or thrush (more details:). For its treatment, there are many various means, however, for pregnant patients, doctors prefer to prescribe the safest of them, namely, pimafucin. Pimafucin is a broad-spectrum antifungal antibiotic that has no contraindications for use during pregnancy. In most cases, pregnant women are prescribed topical therapy with pimafucin in the form vaginal suppositories. The duration of treatment depends on individual characteristics body and the course of the disease and can be from 3 to 9 days. The drug is injected into the vagina one suppository at night, before going to bed.

What is an indication for the appointment of pimafucin?

During pregnancy, due to hormonal changes in the body of a woman, it immune defense the microflora of the vagina is weakened, the microflora of the vagina changes, and these factors create an opportunity for a fungal infection. Against its background, a woman can develop inflammatory processes such as vaginitis, vulvitis or vulvovaginitis. They affect the skin and mucous membranes of the vulva and vagina, causing itching, burning and discomfort. Like any inflammatory disease, candidal vaginitis, vulvitis and vulvovaginitis adversely affect the course of pregnancy. In cases of particularly severe complications, candidiasis is the cause of thinning and weakening of the membranes of the fetus under the influence of waste products of fungi, which can lead to their premature rupture. In addition, during childbirth, a child can become infected with candidiasis when passing through the birth canal. Therefore, the doctor must, on the one hand, prescribe effective treatment thrush, and on the other hand, pick up such medicine, which will not adversely affect the fetus and the course of pregnancy. Such a drug is pimafucin. Its active substance, natamycin, has a local effect on fungal cells, disrupting the integrity of their membranes and thereby causing the death of microorganisms. At the same time, the drug itself has only a local effect and is not absorbed from the surface of the skin or mucous membrane into the blood, that is, it does not penetrate the uteroplacental barrier.

How is pimafucin therapy carried out?

There are several dosage forms of this drug. Treatment with pimafucin during pregnancy is most often carried out topically. The perinatologist prescribes to a pregnant woman therapy with pimafucin vaginal suppositories containing 100 mg of natamycin. In this case, the suppository is inserted deep into the vagina once a day before bedtime in the supine position. After the introduction of the suppository, it is advisable not to get up for several hours, since under the influence of body heat the suppository quickly dissolves with the formation of a foam that evenly covers all the mucous membranes. If you stand up at this moment, the active substance will quickly flow out of the vagina and medicinal effect will be minimized. In most cases one treatment course pimafucin suppositories are enough to cure genital candidiasis.

In order to avoid recurrences of candidal lesions of the vagina, it is necessary that the woman's partner is also treated. Even if he does not have any symptoms of thrush, the causative agents of this disease may be under foreskin, on the head of the penis and, once on the mucous membrane of the vagina, begin to actively multiply there. Therefore, the partner of a woman who is being treated for candidiasis is advised to local therapy using pimafucin in the form of a 2% cream. The cream is applied to the skin and mucous membranes once or several times a day. Treatment continues for several days after the disappearance of the symptoms of the lesion in both partners.

With a strong weakening of the immune system, candidiasis sometimes affects the mucous membranes of the oral cavity. In this case, doctors recommend using pimafucin in the form of a 2.5% suspension for topical treatment. However, such defeat oral cavity occurs rarely in adults.

What is the duration of treatment with pimafucin during pregnancy?

The duration of local treatment with suppositories is determined by the intensity of the disease and can range from 3 to 9 days.
At systemic therapy it is recommended to take 1 tablet of pimafucin 4 times a day for 7-10 days. Pimafucin does not have a teratogenic effect on the fetus, does not penetrate from the intestine into the mother's blood, that is, does not cause any harm to the child, therefore its use is allowed throughout the entire period of pregnancy.

Quite rarely, there is a side effect of the drug when taken orally, which manifests itself in the form of nausea and diarrhea. It does not require discontinuation of treatment and passes by itself after a while. At topical application a feeling of discomfort and burning is possible.
An overdose of pimafucin does not cause any toxic damage to the body.

The only contraindication to the appointment of pimafucin is the patient's hypersensitivity to the components that make up the drug.

Pimafucin during pregnancy: Reviews

In some cases, treatment with pimafucin may not give a positive effect, but most often this happens when the drug is taken for an insufficiently long time.

Nevertheless, in the vast majority of cases, pimafucin, if not completely destroying the causative agents of a fungal infection, then significantly facilitates its course, eliminating unpleasant and even painful symptoms. Here are the reviews of several women about the treatment with pimafucin:

Catherine I've dealt with thrush before pregnancy. But then she took diflucan, which helped her well. In the first weeks of pregnancy, noting the familiar symptoms of thrush, Ekaterina wanted to cure her in the usual way, but before taking the Diflucan tablet, she decided to read the instructions for the drug. Seeing that this drug contraindicated for use during pregnancy, the woman did not self-medicate, but went to the doctor. She was prescribed a six-day course of pimofucine suppositories. Ekaterina felt relief after the very first day of treatment. After the full course suppositories, the symptoms of thrush did not recur until the 30th week of pregnancy. At this time, there was a relapse of the disease, and Ekaterina was prescribed complex therapy tablets and suppositories of pimafucin. After a week of treatment, the symptoms of thrush disappeared and did not reappear.

Ksenia I first encountered thrush at the 19th week of pregnancy. The itching and burning sensations were very unpleasant. The doctor prescribed a woman pimafucin suppositories for a three-day course. The symptoms of thrush disappeared, but the improvement was short-lived. Two weeks later, Ksenia again came to the doctor with complaints about thrush. This time, she was prescribed pimafucin in suppositories for 6 days, in tablets, 1 piece 4 times a day for a week, and recommendations were given for treating her husband with 2% pimafucin cream. After all the doctor's prescriptions were fulfilled, the thrush no longer bothered Xenia.

Svetlana did not notice any unpleasant symptoms, but on scheduled admission at the antenatal clinic at 12 weeks of gestation, the perinatologist told her that the Candida fungus was found in the smear in significant amount and treatment is needed. Svetlana did not follow the doctor's recommendations, as she was afraid of harming the child with "extra chemistry". After a few weeks, she began to notice abundant curdled discharge who scared her. After visiting a doctor whom she completely trusted, the woman asked for the safest medicine possible. She was recommended topical treatment with pimafucin suppositories for 6 days. This time, Svetlana followed all the doctor's instructions, and the treatment helped her.

Pimafucin during pregnancy is one of the most safe drugs therefore, one should not question the recommendations of a doctor who prescribes a course of pimafucin to a pregnant woman. In the vast majority of cases, this drug will help the expectant mother solve her problems, and most definitely will not cause the slightest harm to the fetus.

Pimafucin is one of the most famous antifungal drugs widely used in gynecological practice. Pimafucin is available in several dosage forms:

• candles for vaginal use;
• cream;
• tablet form.

The mechanism of action of this drug is based on binding to the elements of the membranes of the cell wall of pathogens of fungal infection. As a result of this, the destruction of cellular structures occurs, leading to the death of the fungal cell. The peculiarity of Pimafucin is that it acts only locally, that is, locally at the site of its application.
This does not prevent this drug from fighting any localization of the fungal process due to a large number dosage forms.

Can Pimafucin be used during pregnancy?

The active substance Pimafucin is not absorbed into the systemic circulation, so this drug has proven to be used in pregnant women. The drug does not affect the fetus, and only a few drugs can boast of this. For a pregnant woman, thrush is a borderline state between the norm and pathology - during gestation, immunity decreases physiologically, respectively, conditionally pathogenic organisms begin to actively multiply.

Indications for the use of Pimafucin

Candles from thrush during pregnancy Pimafucin is used for fungal infection vagina.

Pimafucin cream for women during pregnancy is used for candidiasis of the external genitalia. Pimafucin in the form of a cream helps to cope with candidiasis of the mucous membranes, skin different localization, otitis externa is also no exception.

The tablet form of Pimafucin successfully copes with candidiasis of the intestines and stomach.

Contraindications to the use of Pimafucin for pregnant women

This drug is absolutely safe when used by a pregnant woman. Pimafucin is often used in the form of suppositories.

The only reason for refusing to use the remedy, which is justified in the case of a pregnant woman, is an allergic reaction to natamycin.

Pimafucin during pregnancy in the 1st trimester

Pimafucin is used in all trimesters of pregnancy. If candidiasis occurs in the first trimester of pregnancy, then, most likely, its etiology should be sought before pregnancy. The cause may be chronic diseases, regular stressful situations or even poor nutrition.

Candles Pimafutsin on early dates pregnancy is absolutely safe for the fetus. With vulvar candidiasis, you can use Pimafucin cream during pregnancy, how to use and the frequency of administration should be checked with your doctor.

Pimafucin during pregnancy in the 2nd trimester

In the second trimester, candidiasis during pregnancy occurs as a result of a physiological decrease in immune status women. This is due to a fairly strong hormonal changes in the body. As a result of these changes, physiological immunosuppression occurs during pregnancy and activation of the candidal flora. Pimafucin (ointment) during pregnancy is used for candidiasis of the external genital organs, which are often involved in the process with vaginal candidiasis.

Pimafucin during pregnancy in the 3rd trimester

In the third trimester, taking the drug is also not contraindicated, and on the contrary, it is indicated. If childbirth occurs through the natural birth canal, it is important that the child walks through a sanitized vagina, since the flora in birth canal women can go to a newborn baby.

Treatment of thrush is necessary at any stage of pregnancy, since as a result of long-term untreated candidiasis, severe consequences in the form of fetal infection.

How often can Pimafucin be used during pregnancy?

During pregnancy, Pimafucin can be used as many times as the situation requires. However, the appointment should be performed only by the attending obstetrician-gynecologist.

Pimafucin during pregnancy: instructions for use

Pimafucin during pregnancy, doctors recommend using one at a time. vaginal suppository at night for about 10 days, depending on the severity clinical manifestations diseases.

The procedure for using other forms of Pimafucin is determined individually by a gynecologist.

Allocations after Pimafucin during pregnancy

Allocations after Pimafucin acquire their normal character- this is the average volume of physiological leucorrhoea without an admixture of a cheesy character.

Pimafucin analogues allowed during pregnancy

You can also use an analogue of Pimafucin suppositories from thrush during pregnancy. These include Ecofucin and Primafungin. Distinctive features are only the country of manufacture of the drug:

• Pimafucin is produced in Denmark;
• Primafungin - in Russia;
• Ecofucin - in Russia.

The price of drugs also varies, Pimafucin is more expensive foreign drug. In the reviews, women note that they do not see big difference V therapeutic effect All three drugs are quite effective.

Thrush or vulvovaginal candidiasis in pregnant women, as before, remains one of the most common pathologies. Therefore, the treatment of this insidious disease with safe drugs at all stages of bearing a baby is topical issue V modern life women. Majority medicinal medicines or prohibited during pregnancy, or simply have not been clinically tested in pregnant women. One of the most harmless and effective means is Pimafucin during pregnancy. Is Pimafucin possible during pregnancy and all the details of its use according to official instructions and will be discussed in this article.

Main culprit disease state- pathogenic fungus candida albicans. Every person has it in small quantities. During pregnancy, immunity decreases and pathogenic microflora begins to multiply actively, thereby causing a number of unwanted diseases. The first in line is candidiasis or, as we all used to call it, thrush.

Symptoms for which thrush can be suspected:

• lumpy discharge white color similar to cottage cheese;
• severe and unbearable itching;
• characteristic sour smell;
• inflammation of the vaginal mucosa: soreness, redness and sensitivity;
• burning sensation and pain when urinating;
• discomfort during intercourse.

Do you know...
Every second woman had thrush even before the onset wonderful moment- pregnancy. Therefore, it is important to pass gynecological examination and take swabs for latent infections until the moment of conception.

The occurrence of thrush is due to a number of factors. The impetus for increased reproduction of the fungus can be both mechanical factors and factors of the state of health of a woman "in position". This infection can roam the body for years without causing any harm. But the body future mother works in an enhanced mode, and is more prone to all sorts of diseases. Weakened immunity fails, and this is precisely the main cause of candidiasis. Lactobacilli under the influence of growing at an accelerated pace pathogenic flora are dying. As a result, pathogenic microorganisms begin to “reign” in the vagina, followed by vaginitis, candidiasis and other “sores”. Such an outcome is considered a variant of the norm during pregnancy, but this does not mean that there is no need to be treated. Just women need more mild treatment with the help of proven and admissible means Pimafucin both during pregnancy and lactation.

What causes thrush during pregnancy:

• synthetic underwear;
• microtrauma of the vagina;
• taking medications: antibiotics, corticosteroids;
• various diseases that lower the immune system. These include: cancer, inflammation, tuberculosis various forms, hormonal dysfunctions, diabetes, hypothyroidism, etc.;
• contamination with the fungus Candida of the gastrointestinal tract;
• avitaminosis and poor nutrition.

A huge misconception is the opinion that thrush is not dangerous for mom and baby. Firstly, fungal contamination of the vagina greatly complicates the already troublesome life of the expectant mother, and secondly, candidiasis can infect the amniotic fluid or be transmitted to the child during childbirth.

Pimafucin: the active substance and its effect on the body of a pregnant woman

Pimafucin is acceptable for use at all stages of pregnancy, including the first trimester. To date, there is not a single case when Pimafucin had even the slightest effect on the fetus and the development of its organs and vital systems. At the same time, it perfectly eliminates inflammation of the pelvic organs and completely neutralizes yeast fungi.

The active component of Pimafucin is natamycin, an antifungal antibiotic that blocks the synthesis cell membranes fungus by binding styrenes. This stops the reproduction of spores and destroys the entire colony of harmful microorganisms. With local absorption, the substance does not penetrate into the bloodstream and does not reach the placental barrier. Pimafucin during pregnancy according to the instructions is absolutely safe for the fetus.

If the thrush does not go away with a second course of treatment, a variant of the woman's body's insensitivity to the medicine is possible. In this case, a laboratory test should be carried out possible types antibiotics that can stop the reproduction of fungi.

Interesting! Pimafucin contains a broad-spectrum antifungal agent. Therefore, this drug is used not only to eliminate the causative agent of thrush, but also in the treatment fungal otitis media and stomatitis.

Dosage forms of Pimafucin and their regimen

Pimafucin is produced in three pharmaceutical forms- suppositories, cream and tablets. The purpose of this or another type of drug depends on the location and degree of contamination with spores of the fungus. Basically, Pimafucin suppositories are prescribed for the treatment of thrush during pregnancy. Under the condition of a stronger inflammatory process oral administration of the tablet form of Pimafucin is allowed.

Candles. One piece contains 100 mg of natamycin. As additional funds there is solid fat, cetyl alcohol, sodium bicarbonate. Pimafucin suppositories according to the instructions for pregnancy are used for 3-6 days. The vaginal suppository should be administered just before bedtime, placing it as deep as possible. After dissolution of the suppository, a foamy mass appears, which completely covers the vaginal mucosa and has a fungicidal (disinfectant) effect on fungi and their spores. At sustainable form thrush treatment is repeated. There is also a mandatory treatment of the sexual partner with a cream.

Pills. Active substance- natamycin (100 mg each), auxiliary agents - starch, talc, lactose, beeswax, acacia, magnesium stearate, kaolin. The shell of the tablet quickly dissolves in the stomach and disinfects the mucosa, while the remains of the active substance are not concentrated in the blood plasma. Pimafucin tablets during pregnancy are prescribed for obvious colonization of the intestines and rectum Candida fungi. The optimal course of therapy is 4 tablets per day for 7 days.

Cream. The composition contains 20 mg of antibiotic for each gram of cream. As a basis, sodium lauryl sulfate, alcohol, oleate, wax, water are used. Pimafucin cream is prescribed during pregnancy externally for skin lesions. The cream is rubbed into inflamed areas up to 4 times daily for 14-21 days.

On a note!
Treatment with Pimafucin is carried out only after a bacteriological examination of the discharged fluid from the vagina. According to the results of bakposev, fungal vaginosis caused by the genus Candida should be confirmed. If the causative agent of the disease is a different infection, then the treatment is selected differently.

Indications: when the drug is used during pregnancy

Diseases caused by fungi of the genus Candida, which are faced by women "in position":

1. Vaginitis.
2. Vulvitis.
3. Vulvovaginitis.
4. Dermatomycosis.
5. Fungal lesions internal organs(intestinal candidiasis).

You need to know!

• During the treatment of candidiasis, you should refrain from sexual intercourse.
• A woman must observe strict hygiene before being cured. by individual means toilet.
• Treatment is carried out immediately for both partners.

Contraindications, side effects and possible risks of Pimafucin during pregnancy

Therapy with Pimafucin during pregnancy from thrush is well tolerated and has practically no contraindications. Only individual intolerance to natamycin is taken into account and additional substances in the composition of the drug. Especially caution should be approached to women with lactose intolerance and allergic reactions for bee products.

During the treatment with Pimafucin, some side effects may occur, but they are observed only in the first days of using the drug and soon disappear. These events include:

• nausea;
• vomiting reflex;
• headache;
• intestinal disorders;
• burning and itching in the genital area;
• hyperemia and swelling of the labia.

Pimafucin in early pregnancy is best used in the form of suppositories, since tablets can increase the symptoms of toxicosis. And starting from the second trimester it is already allowed complex treatment thrush.

On a note! If, when using Pimafucin vaginal suppositories before pregnancy, there were discomfort, then you should immediately warn the gynecologist about this before starting treatment.

It is better to get ahead of the disease than to seek a cure. The most current prevention thrush is healthy sleep, excellent nutrition, the absence of untreated infections and a favorable atmosphere at home. An established regimen during pregnancy will not only prevent thrush, but also all complications in an “interesting” position. If the thrush "stubbornly" worries women, you can easily fix it with the help of Pimafucin during pregnancy, the use of which will definitely not harm the baby.

Video: "Thrush during pregnancy"

The active substance (INN) is natamycin.

Analogues with the same substance:

• Primafungin (one and a half to two times cheaper);
• Ecofucin.

Can be used as an analogue antifungal suppositories if there are no contraindications:

• Candide (50-100 r);

Not all drugs are equally safe, read the instructions before using them. List of safe drugs for pregnant and lactating mothers.

Price

average price online (6 pcs) * : 507 r.

The partner is strongly recommended to use pimafucin cream throughout the course of treatment, for the prevention of male candidiasis and candidiasis. The need to interrupt sexual life no, but barrier type contraceptives should be used.

Contraindications

Hypersensitivity to natamycin or other components of the drug.

Can be taken during pregnancy and lactation.

The drug does not enter the mother's blood and does not affect the fetus (child).

During critical days, tablets are recommended (but not pimafucin!).

Use during pregnancy and breastfeeding

Almost the only drug for thrush, allowed at all times, including 1 trimester. For the simple reason that the drug is not absorbed into the blood either through the gastrointestinal tract, or through the skin, or through the mucous membranes, it has only local action.

Side effects

The drug pimafucin is one of the most gentle for the human body, there are almost no side effects. IN rare cases burning and slight irritation are possible.

Pharmacology and pharmacokinetics

Antifungal polyene antibiotic from the group of macrolides, having wide range actions. It has a fungicidal effect.

Natamycin binds sterols of cell membranes, violating their integrity and function, which leads to the death of microorganisms.

Most pathogenic yeast fungi are sensitive to natamycin, especially Candida albicans. Dermatophytes are less sensitive to natamycin.

resistance to natamycin clinical practice does not occur.

Natamycin tablets, due to the enteric coating, act only in the intestines.

Natamycin is not absorbed from the gastrointestinal tract, through intact skin and mucous membranes.

Other

When administered intervaginally, it is practically not absorbed into the blood and does not systemic action. Cases of overdose with pimafucin have not been recorded.

During the period of menstruation, candle therapy is not recommended.

Does not affect the ability to manage vehicle and other mechanisms.

Sold without a prescription. Shelf life - 2 years, storage temperature - from 15 to 25 degrees.