The use of suppositories for temperature control for adults. List of effective antipyretic drugs for adults Antipyretic drugs are inexpensive but effective

Antipyretics belong to the group of NSAIDs. Nonsteroidal anti-inflammatory drugs are drugs that exhibit anti-inflammatory, analgesic, and antipyretic effects.

In the inflammatory focus, under the influence of damaging factors, the production of prostaglandins is activated. This process is carried out with the participation of cyclooxygenase enzymes (COX-1 and COX-2).

It is prostaglandins that are considered modulators and mediators of inflammation, stimulating the formation of histamine, kinins, and serotonin, which take part in the formation of pain and fever.

According to the mechanism of action, all NSAIDs are divided into:

  • selectively inhibiting COX-1 (acetylsalicylic acid);
  • non-selective inhibitors of COX-1 and COX-2 (indomethacin, diclofenac);
  • selective inhibitors of COX-2 (nimesulide);
  • highly selective COX-2 (celecoxib).

When the activity of cyclooxygenase decreases, the production of prostaglandins decreases, due to which the energy supply in the inflammatory focus decreases, the pyrogenic effect on the thermoregulatory center in the brain decreases, and heat transfer increases.

1st generation NSAIDs have a non-selective effect on COX. This group of drugs includes paracetamol, ibuprofen, acetylsalicylic acid, phenylbutazone and others.

These substances inhibit the production of both COX-1 and COX-2. Due to this, many side effects occur. Among which the most common manifestations are oliguria, bronchospasm, exacerbation peptic ulcer stomach and duodenum, disturbances in the functioning of the gastrointestinal tract, kidneys and liver.

Important:

If a high temperature in an adult lasts no more than 2 days, it is most advisable to take Paracetamol (also belongs to the group of analgenics-antipyretics). This is the only drug that acts directly on the thermoregulation center.

  • Panadol, tab. 500 mg No. 12 – 55 rubles;
  • Panadol, soluble tablets 500 mg No. 12 – 75 rubles;
  • Nurofen, tab. 200 mg No. 10 – 100 rubles;
  • Mefenamic acid, caps. 250 mg No. 20 – 120 rub.

Panadol

The drug is based on paracetamol and belongs to the anilides group. It has an analgesic, antipyretic, and mild anti-inflammatory effect.

As a monotherapy, it is acceptable to take it for pain of minor intensity (headache, dental, muscle, menstrual pain), to reduce body temperature above 38.5 against the background of ARVI and influenza.

The drug is contraindicated in case of hypersensitivity to the main active ingredient, severe impairment of the kidneys, liver, deficiency of the enzyme glucose-6-phosphate dehydrogenase, any blood diseases, children under 9 years of age weighing less than 35 kg.

Patients with Gilbert's syndrome, pregnant women and during lactation should take Panadol with extreme caution.

Side effects most often include disturbances in the functioning of the gastrointestinal tract, hepatotoxicity, thrombocytopenia, leukopenia, agranulocytosis, allergic reactions in the form of skin rash, itching, and urticaria.

Adults are recommended to take 1-2 tablets. no more than 4 times a day, and the interval between doses should be at least 4 hours. You should not take Panadol for more than 5 days as a pain reliever and no more than 3 days as an antipyretic.

The soluble form of tablets allows minimizing negative impact on the mucous membranes of the gastrointestinal tract. In addition, the speed of onset of the antipyretic effect is higher: a decrease in temperature is observed after 20 minutes.

Advantages of paracetamol-containing drugs:

  • the safest analgesic-antipyretic according to WHO;
  • relatively low cost;
  • high efficiency in ARVI;
  • over-the-counter release.

Flaws:

  • a wide list of side effects, among which hepatotoxicity is most often diagnosed;
  • a large list of contraindications;
  • practically does not exhibit antipyretic effect when bacterial infections.

Nurofen

The drug without paracetamol - contains ibuprofen, which is a derivative of phenylpropionic acid. Shows good analgesic, antipyretic, anti-inflammatory activity.

The main indications for use of the drug are headache/toothache, migraine, neuralgia, myalgia, arthralgia, rheumatism, manifestations of influenza and ARVI, increased body temperature of any origin.

Contraindications to the use of Nurofen are gastric ulcers, pathologies of cardio-vascular system, including heart failure, arterial hypertension, hypersensitivity to other NSAIDs, visual impairment, glucose-6-phosphate dehydrogenase deficiency, any type of hemophilia, leukopenia, kidney disease, liver disease.

Side effects include dyspeptic disorders, sensitization reactions, Stevens-Johnson and Lyell syndromes, headaches, dizziness, sleep disturbances, tachycardia, increased blood pressure.

Advantages:

  • has not only antipyretic but also analgesic effects;
  • effectiveness in reducing temperature during ARVI and bacterial complications;
  • relatively low cost.

Disadvantages: wide list of contraindications and side effects.

Mefenamic acid

It belongs to the group of NSAIDs, but in addition to the anti-inflammatory and antipyretic effect, it stimulates the production of interferon.

The anti-inflammatory effect is due to the ability to inhibit the production of inflammatory mediators and reduce the activity of lysosomal enzymes.

Mefenamic acid stabilizes protein structures cell membranes, reduces their permeability, increases the resistance of cells to the effects of foreign agents. The antipyretic effect is associated with inhibition of prostaglandin synthesis and an effect on the thermoregulatory center of the hypothalamus.

The drug is recommended in complex therapy ARVI and influenza, to relieve pain from muscle, joint, headache, toothache, and diseases of the musculoskeletal system of inflammatory origin.

Contraindications for use are hypersensitivity to the components of the drug, a history of bronchospasm, Quincke's edema, urticaria after using other NSAIDs, peptic ulcer of the stomach and/or duodenum, diseases of the hematopoietic organs, heart failure.

You need to take the drug 250-500 mg no more than 4 times a day, washed down with milk. If necessary, the daily dose can be increased to 3000 mg, after which it is gradually reduced to 1000 mg.

Advantages:

  • additional antiviral effect allows you to achieve a speedy recovery;
  • low cost of the product;
  • The drug is generally well tolerated.

Flaws:

  • features of administration (the need to take it with milk to increase the bioavailability of the drug);
  • contraindications and side effects characteristic of other NSAIDs.

In addition, it is possible to receive acetylsalicylic acid(Table No. 10 - about 9 rubles), analgin (Table No. 10 - 15 rubles). However, these drugs often provoke the development of serious side effects.

In addition, aspirin should not be taken to reduce fever during influenza and ARVI, since it can provoke the development of internal bleeding.

For cupping side effect Can you take acetylsalicylic acid tablets with alkaline tablets? mineral waters, but this significantly reduces the effectiveness of the drug.

Metamizole sodium, or analgin, is banned in many countries. This is due to the fact that monotherapy with this drug provokes the development of rapid sensitization reactions (allergy).

Also, clinical trials have proven that metamizole sodium helps reduce the number of white blood cells, and this leads to a decrease in the body’s resistance to the effects of viruses and pathogenic microorganisms.

Second generation drugs

2nd generation antipyretic drugs have been developed over the past 20 years. They selectively affect COX-1 or COX-2, which has reduced the list of contraindications and side effects, but their negative impact on heart function has been proven.

In addition, their intake does not depend on food intake.

Antipyretics for high temperature from this group are represented by drugs containing nimesulide (Nise, tablet 100 mg No. 20 - 190 rubles, Nimesil, pack of 2 g No. 30 - 680 rubles) and meloxicam (Movalis, tablet 15 mg No. 10 - 675 rubles).

Nise

Exhibits analgesic, antipyretic, proinflammatory effects. Used as a strong antipyretic for adults, pediatric practice prohibited.

Prescribed primarily as an anti-inflammatory drug for rheumatoid arthritis, articular syndrome during exacerbation of gout, psoriatic arthritis, osteochondrosis, myalgia.

Contraindicated in pronounced violations kidney function, hypersensitivity to nimesulide, gastric ulcer. Prescribed with caution when increasing blood pressure, heart failure, type 2 diabetes. The most common side effects are skin allergic reactions.

As an antipyretic, it is recommended to take 50-100 mg up to 2 times a day. The course of admission is no longer than 3 days. The advantage of Nise is its release form - sublingual tablets. That is, the drug dissolves in the mouth and has a pleasant sweetish taste.

Nimesil

Allows you to reduce Negative influence on the gastric mucosa, and the antipyretic effect occurs faster. However, it is available in powder form and the need to dissolve the contents of the sachet may cause some inconvenience to the patient.

Movalis and other drugs containing meloxicam are rarely used as antipyretics. However, like other NSAIDs, they are quite effective and quickly reduce body temperature.

Movalis is available in the form of tablets and suppositories. Suppositories are more effective, since the rectal route of administration allows achieving a therapeutic effect within 15 minutes.

Combined products

Combined antipyretic drugs have a complex effect, due to which it is possible not only to reduce body temperature, but also to improve the general well-being of the patient.

The list of such drugs is as follows:

  • Ibuklin, tab. 400 mg + 325 mg No. 10 – 125 rubles;
  • Aspirin-C, tab. effervescent No. 10 – 255 rubles;
  • Coldact Flu Plus, caps. No. 10 – 175 rubles;
  • Rinza, tab. No. 10 – 155 rubles;
  • Coldrex, tab. No. 12 – 160 rub.

Ibuklin is a strong antipyretic, contains paracetamol and ibuprofen, due to which it effectively reduces hyperthermia during influenza and acute respiratory viral infections, and quickly eliminates headaches, toothaches, and muscle pain.

You should take 1 tablet. no more than 3 times a day. Contraindicated for gastric ulcers, renal and liver failure, blood diseases, bronchial asthma, polyposis.

Aspirin-C combines acetylsalicylic and ascorbic acids. It is applied for symptomatic treatment pain of moderate and moderate intensity, decrease in body temperature above 38 degrees.

The drug is contraindicated for diseases of the gastrointestinal tract, blood, liver and kidney pathologies, a history of bleeding of any etiology, and vitamin K deficiency.

You should take 1-2 tablets, which are dissolved in 100 ml of water. The maximum daily dose is 6 tablets.

Coldact Flu Plus effectively reduces temperature, eliminates nasal congestion, and improves the general well-being of the patient. Contains paracetamol, phenylephrine, chlorpheniamine. The drug should be taken one capsule every 12 hours.

They also have a similar composition Rinza and Coldrex. Rinz tablets should be taken up to 4 times a day. Coldrex, in addition to the indicated components, contains caffeine, terpene hydrate, and ascorbic acid. Such complex composition Helps effectively reduce fever against the background of influenza and ARVI.

Important:

It should be borne in mind that all combined antipyretic drugs have more wide list contraindications and possible side effects in contrast to monocomponent ones.

Drugs for pregnant women

Among the many antipyretic drugs for pregnant women Paracetamol or its analogues are allowed only as prescribed by a doctor. It belongs to the group of analgesics-antipyretics that affect the thermoregulation center. Paracetamol also effectively fights headaches and toothaches.

The permissible dose for pregnant women is one tablet no more than 3 times a day. However, it must be taken into account that an overdose and long-term use The drug can provoke the development of attention deficit disorder and neurological disorders in the unborn child.

Can be recommended for pregnant women as an antipyretic Viburkol candles. It's complex homeopathic remedy, exhibiting analgesic, anti-inflammatory, sedative, antispasmodic, antipyretic effects.

The drug is used in the complex therapy of acute respiratory viral infections, influenza, convulsive syndrome, nervous overexcitation, inflammatory diseases ENT organs, pathologies genitourinary organs inflammatory genesis.

In acute cases of the disease, it is allowed to use suppositories every 20 minutes for 2 hours. After this they put 1 supp. no more than 3 times a day. The duration of therapy is no more than 2 weeks.

The most common side effect is hypersensitivity to the components of the drug.

Important:

Any medications during pregnancy should be taken only as prescribed by a doctor. Only a specialist will be able to balance the potential risk for the developing fetus and the benefits for the expectant mother.

Alternative ways to reduce fever

Main alternative method To reduce the temperature, drink plenty of warm drinks. An adult should drink at least 2 liters of water per day. Thanks to this, metabolic processes in the body are accelerated and pathogenic microorganisms, viruses and their metabolic products are eliminated faster.

On the forehead, groin area, inner side Apply cold compresses, such as a wet towel or ice packs, to the elbows (where large veins emerge) and remove them every 10 minutes to prevent hypothermia.

These methods can only be used if the body temperature rises no more than 39 degrees. Otherwise, you should immediately call a doctor.

Types of antipyretic drugs and features of their use

Antipyretic drugs are one of the most popular medications, since almost every person experiences an increase in temperature. The variety can be confusing, and some popular pills are illegal in other countries. Before deciding on the choice of medication, you should understand in what cases it is necessary to take it.

Critical body temperature values

It is not always necessary to take antipyretic pills. Fever is a natural reaction of the body to an irritant. At the same time, the human body produces interferon, which helps it fight the virus. Drugs to reduce fever do not affect the healing process, but only eliminate some manifestations of the disease.

If it is possible to spend several days in a gentle mode, alleviating the condition only by physical methods exposure (drinking plenty of fluids, ventilating the room, cooling compresses), it is better to stop taking medications. The body itself will be able to cope with a cold.

But there are cases in which antipyretics are necessary:

  • bacterial infection;
  • poor “tolerance” of increased temperature;
  • convulsions or tendency to them;
  • temperature from 38 to 38.5 ° C in pregnant women and children under two months;
  • temperature from 38.5°C in young children;
  • temperature from 39°C in adults.

If antipyretic drugs, the list of which is quite extensive today, do not help within an hour, then you need to seek emergency help.

What medications reduce fever?

Drugs that can reduce fever, relieve pain, and reduce inflammation are nonsteroidal anti-inflammatory drugs (NSAIDs). They are non-hormonal and act by inhibiting the two-part enzyme cyclooxygenase. It is responsible for the production of substances that signal the thermoregulation center about the need to increase the temperature.

NSAIDs are divided into two categories of drugs:

  • first generation. Active ingredients: ibuprofen, paracetamol, acetylsalicylic acid, phenylbutazone, diclofenac, metamizole sodium, indomethacin and others. Both parts of cyclooxygenase are inhibited. Observed significant amount side effects - oliguria, bronchospasm, ulceration, organ dysfunction gastrointestinal tract(gastrointestinal tract), liver and kidneys.
  • second generation. Developed in the last 20 years. Active ingredients: meloxicam, nimesulide, coxibs. Inhibits individual parts of cyclooxygenase. They do not have the disadvantages of first-generation drugs, but have a negative effect on the functioning of the heart.

As the use of antipyretics increases, the risk of side effects also increases. The medicine should be taken only after the temperature rises, and not in order to avoid it.

Drugs for adults

It is better to take monocomponent medications: they are more easily absorbed by the body and cause fewer adverse reactions. But you cannot use other drugs containing the same active ingredients in parallel, as this will increase their dosage. In medical practice The most common are first-generation NSAIDs, based on one of the following substances:

  1. Paracetamol. Preparations in tablets or powders - paracetamol and combination drugs based on it (ibuclin, panoxen, Coldact, Tylenol, Theraflu, Efferalgan, Coldrex, Panadol, Rinza). Should be taken no more than 4 times a day at a dosage of 500–1000 mg. These drugs are recommended to relieve fever and pain. Paracetamol in pure form does not cause significant negative consequences. Negative effects on the liver or allergic reactions are possible if the dosage is not observed. Ibuklin also contains ibuprofen, and panoxen contains diclofenac, which enhances their therapeutic effect.
  2. Ibuprofen. Medicines in tablets – ibuprofen, nurofen, novigan. It is allowed to take no more than 3-4 times a day at a dosage of 200-400 mg. In addition to antipyretic and analgesic effects, it also has anti-inflammatory properties. Fast-acting, safest and most effective remedy.
  3. Acetylsalicylic acid. Drugs in tablets - aspirin, askofen, acetylsalicylic acid, citropak, citramon. Take 2–6 times a day, 40–1000 mg. Universal remedy with antipyretic, anti-inflammatory and analgesic properties. Among the negative consequences, malfunctions in the functioning of the cardiovascular, digestive and respiratory systems are noted, therefore use by children under 12 years of age is not recommended. Aspirin should not be taken if you have the flu because it can cause bleeding. Askofen and citramon also contain paracetamol. To reduce the risk of thrombosis, a dosage of 75–150 mg per day should be maintained. Acidic drinks (juice) will help enhance the effect of the medicine, but this worsens the condition of the gastrointestinal tract. If there are problems at work digestive system, you can use alkaline drinks (mineral water).
  4. Metamizole sodium. Drugs in tablets - analgin, baralgin, took, trialgin, spazgan, revalgin. Take 250–300 mg 3 times a day. This antipyretic for adults helps cope well with pain of various natures, and to a lesser extent with fever and inflammation. In emergency situations, it is prescribed by a doctor intramuscularly to reduce high fever. Self-administration of drugs based on metamizole sodium can provoke the development of serious allergic reactions, causing anaphylactic shock with fatal. It has been proven that this medicinal substance leads to a decrease in the number of white blood elements, reducing the body's resistance to viruses and bacteria. This drug is banned in a number of countries. The main advantage of drugs containing metamizole sodium is their low cost and the possibility of rapid administration into the body by injection.

Antipyretic suppositories for adults are used in cases where taking drugs orally is difficult due to various reasons. The most popular among them are the following:

  1. Paracetamol. Prescribe 0.25–0.5 g up to 4 times a day for pain or fever.
  2. Voltaren. NSAIDs based on diclofenac sodium. Prescribed for inflammatory diseases, pain and feverish symptoms. The recommended dosage is 50 mg up to 3 times a day.
  3. Meloxicam. Meloxicam-based NSAIDs. Indications – various shapes arthritis. It is recommended to use 15 mg per day, that is, one suppository.
  4. Cefekon N. NSAID based on acetylsalicylic acid. Prescribed for pain syndromes and feverish conditions caused by the inflammatory process. Use 1 to 3 suppositories per day.
  5. Indomethacin. NSAIDs based on indoleacetic acid. Used for disorders of the musculoskeletal system, genitourinary system, ENT organs. Prescribe 25–50 mg up to 3 times a day.

Compared to tablets, antipyretic suppositories act much faster and most often do not have a negative effect on the gastrointestinal tract.

Medicines for children

Antipyretics for children are used only in extreme cases due to the presence of side effects. But if taking them is necessary, then you should know which type of drug is preferable. Children's medications have several forms of release:

  1. Candles. Suitable for the youngest children. The action appears after 40 minutes, is easy to use and effective. It is recommended to use them before bedtime.
  2. Syrups and mixtures. For older children who can drink from a spoon. Effective in 30 minutes. The pleasant taste of these drugs is usually achieved thanks to special additives, which sometimes cause allergies.
  3. Pills. For children who can swallow them.

The child may also be allergic to the main substance of the drug. Therefore, before giving children an antipyretic, you should consult your doctor. The mandatory break between taking medications is 4 hours.

As in adults, antipyretic drugs for children are NSAIDs with various active ingredients in their composition. The following drugs are available for children: analgin, amidopyrine, aspirin, butadione, voltaren, ibuprofen, indomethacin, naproxan, nimesil, paracetamol. But most of these drugs have a negative effect on critical systems body.

Prohibited antipyretic drugs for children, the list of which includes acetylsalicylic acid, antipyrine, metamizole sodium, amidopyrine, nimesulide, phenacetin, can lead to severe impairment internal organs and even fatal outcome. Before the purchase children's drug to reduce fever, you should carefully study its composition, since a large number of drugs contain the listed components, but are presented under different names.

The main antipyretics for children are paracetamol and ibuprofen. Their effect is weaker than other drugs, but they are safer. The combined drug ibuklin, which includes both substances, is prescribed for diseases unknown etiology. The usual dosage is up to 15 mg/kg of the child’s weight. But each case is individual, and the doctor’s instructions should be followed. Features of taking these drugs:

  1. Paracetamol (Tylenol, Panadol, Dofalgan, acetaminophen, Calpol, Efferalgan, Cefekon D). Release form: suppositories, syrup, tablets. It has an effective effect if the disease is viral in nature. It is quickly absorbed from the gastrointestinal tract, reduces temperature by 1–1.5°C, and lasts up to 4 hours. Should not be used for more than 3 days, as liver function may be impaired. For newborns, the drug is given at intervals of 8 to 12 hours to avoid overdose. Daily dose up to 60 mg/kg body weight. Side effects may include allergic reactions, irritability, dizziness, and rarely bronchospasm.
  2. Ibuprofen (nurofen, ibufen). Release form: suppositories, tablets, syrup, suspension. It acts faster and stronger than paracetamol, but has more negative effects. Prescribed in case of a clearly expressed inflammatory process accompanied by severe painful sensations and fever. Side effects affect the gastrointestinal tract, cause a decrease in the formation of leukocytes in the blood and urine excretion. The maximum daily dose is 40 mg/kg.

Antipyretic suppositories for children are produced on the basis of paracetamol, ibuprofen and analgin. They have more long action than tablets or syrup. Sometimes the doctor prescribes the first dose of the drug in the form of syrup, and the next - suppositories to prolong therapeutic effect. In addition to NSAIDs, homeopathic viburkol suppositories are also used, which are aimed at reducing pain and temperature.

All antipyretic drugs have side effects. Therefore, it is better to do without them. But when taking medications is unavoidable, you should use the most harmless ones and carefully follow the instructions.


Elevated body temperature is the body's protective reaction to the penetration of infectious agents. Each of us has encountered a similar condition, so antipyretics for adults can be called the most popular medications that are literally swept off pharmacy shelves during the flu and cold season.

However, do not forget that you should not lower the temperature to a certain limit, since this is how the body resists infection. But in cases where the patient’s well-being worsens, and high temperature aggravates the condition and threatens the development of complications, it is necessary to fight it. How to choose the right drug among the wide range of antipyretic drugs presented on the shelves of pharmacies? Our review will help you with this, in which we will tell you about the features, properties and methods of using the most popular medications.

Antipyretics for adults at high temperatures - types

How do fever medications work? When the temperature rises in the patient’s body, the formation of prostaglandin E (an active mediator of inflammation) begins, which is main reason feverish condition. Antipyretics interrupt this entire process and inhibit the synthesis of prostaglandin, as a result of which body temperature decreases.

All antipyretic drugs for adults can be divided into nonsteroidal anti-inflammatory drugs (NSAIDs) and opioid analgesics. The list of antipyretic drugs is extensive; NSAIDs alone are currently represented by 15 groups of drugs. Each remedy has its own characteristics and differs in the degree of analgesic, antipyretic and anti-inflammatory effect. After their appearance on the pharmaceutical market, NSAIDs quickly replaced opioid analgesics, due to the fact that drugs in this group had fewer dangerous side effects associated with respiratory depression. Let's take a closer look at the representatives of this group of drugs.

Antipyretic NSAIDs are divided into two categories:

  • First generation drugs (paracetamol, indomethacin, aspirin, ibuprofen, citramon, etc.) have a powerful anti-inflammatory effect, but provoke whole line negative reactions. Among them are the development of bronchospasm, dysfunction of the liver and kidneys, ulcerative lesions gastrointestinal organs.
  • Second-generation antipyretics are produced on the basis of coxib, meloxicam and nimesulide. They are safer, do not have the disadvantages of their predecessors, but can cause disorders of the cardiovascular system.

Doctors recommend that adult patients take single-component medications to reduce fever. Such drugs act faster and are better absorbed. Of course, when taking it, you must follow the recommended dosages and do not combine drugs with similar action to prevent overdose. Statistics show that doctors more often prescribe first-generation antipyretic drugs to adult patients.

The best antipyretics for adults

Antipyretics are produced in different dosage forms ah: in the form of tablets, capsules, injection solutions, syrups, suspensions, rectal suppositories. Suppositories and sweet syrups are usually prescribed to young patients. For adults, it is preferable to take drugs in tablet form. IN severe cases, when the temperature rises to pathological values, injection solutions are used; they act faster and more efficiently than their analogues.

In other cases, adult patients are prescribed antipyretic tablets. Let's take a closer look at the properties and method of use of the most popular drugs:

    1. . The drug has a pronounced analgesic and antipyretic effect. This remedy does not cope so effectively with the inflammatory process. Judging by patient reviews, paracetamol quickly reduces high fever. In addition, it does not contain harmful chemical components (dyes, flavors) that are present in antipyretic powders for preparing hot drinks. For adults, it is better to take paracetamol in 500 mg tablets. The daily dose should not exceed 4 g, since active substance may cause unwanted side effects from the digestive and nervous system. Contraindications to taking paracetamol are kidney and liver pathologies, chronic alcoholism, individual intolerance. average price The price of the drug is 17 rubles.
    2. . Main active ingredient This drug is diclofenac sodium. Voltaren relieves pain well and fights fever. The standard dose for adult patients is 1 tablet up to 3 times a day. The average price of Voltaren is 500 rubles.
    3. Ibuklin is a derivative of paracetamol. This combination remedy consists of paracetamol and ibuprofen. Ibuklin is well tolerated by almost all patients and provides an ideal therapeutic effect. Available in tablets. For adults, the drug is recommended to take 1 tablet three times a day. Contraindications to the use of Ibuklin are ulcerative processes, pregnancy, lactation, liver and kidney pathologies, chronic alcoholism. approximate cost- 118 rubles.

    1. . One of the most popular antipyretic drugs. The active substance is paracetamol. The drug is available in the form of tablets coated film-coated, syrup (for children), effervescent tablets and rectal suppositories. Has a minimum of contraindications. Among them are individual sensitivity, liver diseases and hematopoietic systems. Among the side effects in in rare cases allergic reactions to the drug are observed, dyspeptic symptoms, changes in blood counts. The price of the drug depends on the form of release, and starts from 40 rubles (for tablets).
    2. Cefekon N. The basis of the drug is acetylsalicylic acid. Helps with feverish conditions, perfectly relieves pain, stops the inflammatory process. The drug is released in the form rectal suppositories. Adults can use no more than three suppositories per day.

  1. Coldrex. The drug is produced in two forms: tablets and powder (Coldrex Hotrem). The drug contains caffeine, paracetamol, ascorbic acid, etc. Coldrex quickly reduces body temperature, relieves pain and relieves cold symptoms: runny nose, nasal congestion. It is not recommended to use the drug for more than 5 days in a row. This tool has quite a lot of contraindications. These are pathologies of the liver, kidneys, heart diseases, diabetes, glaucoma, alcoholism, etc. Therefore, before use, it is necessary to consult a specialist and clarify the dosage of the medication. The average price of Coldrex is 163 rubles.
  2. Indomethacin. One of the most active first generation NSAIDs, mainly active substance which is indolylacetic acid. At infectious and inflammatory diseases of ENT organs helps to alleviate the condition, exhibits antipyretic and analgesic properties. Available in the form of tablets and suppositories. Compared to the tablet form, suppositories provide more quick effect and do not cause side effects. The cost of the drug is from 90 rubles.
  3. Coldact(in capsules). A long-acting combination drug intended for the treatment of influenza and ARVI. Shows powerful analgesic properties, fights fever, feverish conditions and rhinorrhea. The basis of the drug is chlorphenamine, paracetamol and phenylephrine. Paracetamol relieves pain, reduces fever, relieves headaches, joint and muscle pain. Chlorphenamine exhibits an antiallergic effect, eliminates itching and irritation of the mucous membranes, and relieves lacrimation. Phenylephrine constricts blood vessels and reduces swelling of the mucous membranes respiratory tract and nasopharynx.

Koldakt has quite a lot of contraindications. These are atherosclerosis of the arteries, hypertension, pathologies of the kidneys and liver, glaucoma, diabetes mellitus, heart disease, ulcerative lesions of the gastrointestinal tract, hypersensitivity, pregnancy, lactation, etc. The drug may cause side effects from various systems body, therefore it should be taken as prescribed by a doctor and not exceed the indicated dosages. The price of the medicine is from 175 rubles.

  • Efferalgan. The drug belongs to the group of analgesics-antipyretics. It is based on paracetamol. Available in the form of effervescent tablets, rectal suppositories, for children Efferalgan is produced in the form of a sweet syrup and solution. Restrictions on taking the medication include blood diseases, liver and kidney pathologies, hypersensitivity to components, pregnancy, and lactation. The cost of the drug is from 200 rubles.
  • Tylenol. Medicine paracetamol-based, intended for the treatment of symptoms colds. Effectively copes with pain syndrome and heat, having a direct effect on the centers of thermoregulation and pain. The main contraindications and side effects are similar to other medications based on paracetamol. It is distinguished by a variety of dosage forms and is available in the form of capsules, suppositories, effervescent powder, suspension and drinking solution. The cost of the drug is from 200 to 450 rubles.
  • Theraflu. Is effective combined agent in the fight against high fever, any kind of pain, cough and chills. The drug contains paracetamol, ascorbic acid, chlorphenamine, pheniramine, phenylephrine, lidocaine as well as dyes and sweeteners. Available in the form of powder for preparing an antipyretic solution, granules for preparing a solution, lozenges and coated tablets, in the form of drops and syrup (for children). Contraindications for use: liver dysfunction, renal failure, diabetes, pregnancy, breastfeeding, etc. The cost of the drug is from 190 rubles.
  • Rinza and Rinzasip. They differ in release form and composition. Rinza is available in tablet form to relieve pain and fever. The tablets contain paracetamol, caffeine and other excipients. Rinzasip (in the form of a hot drink powder) is effective in relieving pain and fever. Both drugs have a number of contraindications: heart disease, kidney and liver dysfunction, glaucoma, arterial hypertension, pregnancy, diabetes, etc. Price from 160 rubles.

  • Aspirin. This drug is non-steroidal drug anti-inflammatory action. Gives an excellent antipyretic, analgesic effect and helps reduce blood clotting. It should be remembered that Aspirin should not be taken to treat the flu. Otherwise, bleeding may occur. Main contraindications: erosions, ulcerative lesions of the gastrointestinal tract, diathesis, hemophilia, liver and kidney dysfunction, pregnancy, individual intolerance, etc. Take for adults no more than 150 mg per day. Aspirin is available in the form of regular and effervescent tablets.
  • includes ibuprofen and other excipients. Available in the form of rectal suppositories, effervescent and film-coated tablets. It has excellent antipyretic, analgesic and anti-inflammatory effects. Nurofen has a number of contraindications: erosions and ulcers of the gastrointestinal tract, heart failure, Crohn's disease, etc. The cost of the drug is from 133 rubles.
  • Analgin. The main active ingredient of the drug is metamizole sodium. It has analgesic, antipyretic and anti-inflammatory effects. Recommended for various types pain, fever, infectious inflammations. The drugs Baralgin and Trialgin are derivatives of Analgin. Such medications should not be taken for kidney and liver pathologies, blood diseases, glucose deficiency, or individual intolerance. average cost drugs of this group - from 40 to 120 rubles.

When should you lower your temperature?

Any antipyretic drugs do not eliminate the cause of the disease, but only stop individual symptoms diseases and improve overall well-being. Therefore, if you have the opportunity to observe for 2-3 days bed rest, give up antipyretic drugs in favor of classical methods treatment: cold compresses, ventilation of the room, plenty of hot drinks with honey, lemon and medicinal herbs.

At low-grade fever(37-37.5°), there is no need to take antipyretic drugs. If your health worsens and the temperature rises above 38.5°, you must call a doctor and follow his recommendations. Antipyretic drugs should be taken in the following cases:

  • if the body temperature of an adult rises to 39 °C;
  • if any chronic diseases The central nervous system, cardiovascular and respiratory systems should take medications at 38° C;
  • with poor tolerance to hyperthermia;
  • with a tendency to develop seizures;
  • when attached bacterial infections.

If, after taking antipyretic drugs, the patient’s body temperature drops to normal values, you should not give him a second dose until the thermometer rises again. If the temperature does not return to normal within 1 hour, you should consult a doctor.

When taking antipyretics, give preference to single-component drugs, since the use of beautiful packaged medications can cause a number of negative consequences and side effects. The reason for this is an overdose. To avoid dangerous complications, it is best to let the body fight the disease on its own. It must be remembered that while taking a multicomponent drug, you cannot take other medications. When the body takes one drug, it needs much less energy to absorb it, so you should not overload it with harmful dyes and preservatives that contain packaged products intended for preparing hot drinks.

Quick relief after taking antipyretic drugs in bags often leads to the fact that a person begins to perceive it as a safe medicinal drink, forgetting that the drug contains strong active ingredients. To avoid overdose, taking any antipyretic drug should not continue for more than three days in a row without consulting a specialist.

We should not forget about many serious illnesses, entailing severe consequences. After all, taking antipyretic drugs distorts clinical picture and makes it difficult to make a correct diagnosis. This results in the doctor being unable to understand the exact cause of your condition and assess the severity of the disease. Another limitation concerns the use of antibiotics. If your doctor has prescribed them, you should not combine these medications with antipyretic drugs.

Thus, despite the availability of a wide range of medicines designed to combat fever and fever, it is dangerous to use them uncontrollably. In any case, a preliminary consultation with your doctor is necessary; you should not self-medicate.

An increase in body temperature means the body is demonstrating a protective reaction to infection. Anyone has encountered this, which is why antipyretic drugs for adults are considered one of the most popular medications.

As you know, body temperature cannot be reduced to a certain point, because... This is how the body fights infection. However, in cases where the patient’s well-being deteriorates, high temperature leads to a worsening of the condition and the development of complications, which is why these remedies are so necessary.

This review presents all the most effective antipyretic drugs, as well as the available features, properties and methods of using these drugs.

Let's figure out how fever remedies work. Increased body temperature of the patient leads to the formation of prostaglandin, which is an active mediator of inflammation and leads to a febrile state. Antipyretic drugs stop this process and prevent the synthesis of prostaglandin, thereby reducing body temperature.

All antipyretic medications for adults are divided into opioid analgesics and nonsteroidal anti-inflammatory drugs (NSAIDs). There are a lot of antipyretic drugs, only NSAIDs are now divided into 15 groups of drugs. Each drug has its own characteristics and differs in the degree of antipyretic, analgesic and anti-inflammatory effect.

After going to pharmaceutical market NSAIDs have quickly eclipsed opioid analgesics due to fewer dangerous side effects associated with respiratory functions. It is NSAIDs that we will dwell in more detail on.

Antipyretic NSAIDs divided into 2 categories:

Doctors advise adult patients to drink single-component drugs to lower the temperature, because they act faster and are easier to digest. Of course, it is important to follow the required dosage when taking it and not use others. similar drugs, because this is fraught with overdose. According to statistics, adult patients are more often prescribed 1st generation antipyretic drugs.

The most effective antipyretic medications for adults

These funds are dispensed in the form of:

  • capsules,
  • tablets,
  • syrups,
  • solutions for injections,
  • rectal suppositories,
  • suspensions.

Sweet syrups and suppositories are usually prescribed to young patients. Adults are recommended to take medications in tablet form. If the temperature rises to critical values, then use injection solutions, because they act more efficiently and faster than their counterparts. In all other cases, adult patients use antipyretic medications in tablets. Next, we will consider in more detail the method of use and properties of the most famous drugs.

Paracetamol

The drug has a pronounced analgesic and antipyretic effect. On inflammatory processes This medication is not effective enough. According to patient reviews, these antipyretic tablets quickly reduce fever.

Paracetamol has no flavors or dyes, which are contained in antipyretic powders for making a hot drink. 500 mg is the recommended dose of paracetamol for adults. The daily dose is no more than 4 grams, because its active substance can lead to undesirable adverse reactions from the nervous and digestive system. Contraindications to the use of this remedy: liver and kidney diseases, individual intolerance, chronic alcoholism. The average cost of paracetamol is 17 rubles.

Coldact in capsules

Is strong combination drug long-acting, intended for the treatment of ARVI and influenza. It has powerful analgesic properties, fights rhinorrhea, fever and feverish conditions. The drug is based on paracetamol, phenylenephrine and chlorphenamine. Paracetamol reduces fever, relieves pain, relieves muscle, joint and headache pain. Chlorphenamine does not cause allergic reactions, eliminates irritation and itching of the mucous membranes, and eliminates lacrimation. Phenylephrine helps to constrict blood vessels and reduce swelling of the mucous membranes of the nasopharynx and respiratory tract.

Koldakt has many contraindications, including: atherosclerosis of the arteries, glaucoma, hypertension, liver pathologies, heart disease, diabetes mellitus, gastrointestinal ulcers, pregnancy, lactation, hypersensitivity, etc. This remedy can cause side effects from many systems of the body and therefore you should use it exclusively as prescribed by a doctor and drink only according to indicated dosages. Cost of the medicine - from 175 rubles.

Coldrex

The drug is available in the form of tablets and powder (Coldrex Hotrem). The medicine contains paracetamol, caffeine and ascorbic acid. Coldrex quickly reduces body temperature, relieves pain and cold symptoms: nasal congestion, runny nose. You should not take the drug for more than five days in a row. This is the remedy has many contraindications. These are glaucoma, alcoholism, heart disease, kidney disease, liver disease, diabetes mellitus, etc. Before use, you should definitely consult a doctor, including to clarify the dosage of the medication. The average cost of Coldrex is around 163 rubles.

When to lower the temperature

All antipyretic medications do not affect the cause of the disease, but only block individual symptoms of the disease and help relieve general well-being. Therefore, if it is possible to comply bed rest for 2-3 days, then in this case you need to abandon antipyretics in favor of cold compresses, ventilation of the room, plenty of hot drinks with honey, lemon and medicinal herbs.

Low-grade fever (37-37.5°C) does not require the use of antipyretics. If your health worsens and your temperature rises above 38.5°, you should call a doctor and follow his recommendations. Taking antipyretic medications is advisable in the following cases:

  • when an adult’s body temperature rises to 39 °C;
  • if there is poor tolerance to hyperthermia;
  • yes there are chronic diseases related to the central nervous system, respiratory system and cardiovascular system, you need to take medications already at 38 ° C;
  • there is a tendency to have seizures;
  • if bacterial infections occur.

If the patient's temperature drops to normal levels due to taking antipyretics, a repeat dose should not be given until a subsequent increase in body temperature. If the temperature has not returned to normal after 1 hour, then you need to consult a doctor.

When using antipyretic medications, preference should be given to single-component drugs, because taking beautiful packaged products can lead to negative consequences and side effects caused by overdose. To avoid dangerous complications, it is advisable to give the body time to fight the disease.

It is important to remember that taking a multicomponent drug excludes the possibility of using other medications. When the body takes one product, much less energy is spent on absorption, so do not overload it harmful additives contained in packaged products intended for preparing a hot drink. Antibiotics should not be taken together with antipyretic drugs.

From all of the above, it follows that the presence large quantity medicines produced to get rid of fever and heat, does not mean the possibility of their uncontrolled use. First of all, it is important to first consult with a specialist, but you should not engage in treatment.

Attention, TODAY only!

The temperature rises because the body “heats up” to cope with the intruders. pathogens. This is a protective reaction and often helps with mild infections. If the high temperature lasts for a long time, it becomes dangerous, it is necessary to use antipyretic drugs.

Rules for reducing high fever

Many people take medications to bring down a fever immediately after cold or flu symptoms appear, but this is not true. Indications for taking antipyretic drugs, according to the instructions, are:

  • the appearance of body aches, headaches, nausea, vomiting, a rise in body temperature to 39 degrees;
  • febrile seizures, temperature up to 38.5 degrees;
  • diseases of the lungs and heart with a temperature above 38.5 degrees.

Contraindications to the use of antipyretics for adults:

  • temperature below 38.5 degrees;
  • intolerance to the components of the drug;
  • taking several antipyretics at once;
  • long-term use (over 3-5 days);
  • pregnancy, lactation.

Side effects may occur when taking anti-inflammatory drugs to reduce fever:

  • allergy, skin rash, Quincke's edema;
  • nausea, diarrhea;
  • anemia, agranulocytosis, leukopenia, thrombocytopenia;
  • colpitis;
  • allergic rhinitis.

Classification of antipyretics by main substance

All antipyretic drugs available in pharmacies for high fever in adults are divided into first and second generation drugs. First generation drugs include drugs with a non-selective effect on cyclooxygenase. These products contain:

  1. Paracetamol is an analgesic-antipyretic that affects the thermoregulation center. Pros: safe, inexpensive, helps with ARVI, available without a prescription. Cons: causes hepatotoxicity, has many contraindications, does not reduce fever in bacterial infections.
  2. Ibuprofen is an antipyretic with an analgesic effect. Pros: effective against acute respiratory viral infections and bacterial infections, inexpensive. Cons: many side effects, contraindications.
  3. Mefenamic acid – has an additional antiviral effect. Advantages: inexpensive, well tolerated. Disadvantages: you need to take it with milk to increase bioavailability, it has many contraindications and side effects.
  4. Acetylsalicylic acid is affordable, but often causes side effects.
  5. Metamizole sodium is an analgin. Banned in many countries because it causes rapid allergies. One of the advantages is the affordable price.

Second-generation drugs for adults selectively act on enzymes, which reduces the number of side effects. The downside is that it has been noted that they often have a negative effect on the heart. These include antipyretics containing:

  1. Nimesulide is prohibited for use by children, it causes allergies. The advantages include a convenient release form and fast action.
  2. Meloxicam – quickly and effectively removes elevated temperature, but cannot be used for more than 3 days due to the risk of side effects.

Effective and inexpensive medications for fever in adults

On sale you can find suppositories, syrup, suspension, and fever tablets for adults. The advantage of oral dosage forms is ease of use, while rectal forms have the advantage of quickly achieving effect. Antipyretic tablets, syrups and suspensions should not be taken for longer than 3-5 days, while suppositories can be used for 10-14 days.

Paracetamol based

Efferalgan

Action

Relieves pain, relieves fever

Anesthetizes, relieves fever, relieves inflammation

Method of administration

Orally, dissolved in a glass of water, no more than 1-2 tablets per day after meals

1 tablet up to 4 times a day, orally

Side effects

Nausea, vomiting, allergies, anemia, urticaria, leukopenia, methemoglobinemia, agranulocytosis, thrombocytopenia, pancytopenia

Skin rashes, itching, anemia, renal colic, nonspecific bacteriuria, interstitial nephritis, papillary necrosis, thrombocytopenia, methemoglobinemia, Quincke's edema

Cost, rubles

185 for 16 tablets 500 mg

50 for 12 tablets 500 mg


Ibuprofen based

Ibuprofen

Action

Inhibits the synthesis of prostaglandins, suppresses the activity of the enzyme cyclooxygenase

Relieves pain, fever, inflammation, suppresses platelet aggregation, has a desensitizing effect

Method of administration

Orally, 200 mg 3-4 times a day

Orally, 200-800 mg 3-4 times a day

Side effects

Nausea, vomiting, heartburn, increased blood pressure, anorexia, diarrhea, flatulence, dizziness, tachycardia, edema, anemia, bronchospasm

Insomnia, aseptic meningitis, nausea, vomiting, heartburn, bronchospasm, urticaria, edema, depression, anorexia, diarrhea, gastropathy, tachycardia, itchy skin, anemia



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