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Antipyretics belong to the group of NSAIDs. Nonsteroidal anti-inflammatory drugs are drugs that exhibit anti-inflammatory, analgesic, and antipyretic effects.
In the inflammatory focus, under the influence of damaging factors, the production of prostaglandins is activated. This process is carried out with the participation of cyclooxygenase enzymes (COX-1 and COX-2).
It is prostaglandins that are considered modulators and mediators of inflammation, stimulating the formation of histamine, kinins, and serotonin, which take part in the formation of pain and fever.
According to the mechanism of action, all NSAIDs are divided into:
When the activity of cyclooxygenase decreases, the production of prostaglandins decreases, due to which the energy supply in the inflammatory focus decreases, the pyrogenic effect on the thermoregulatory center in the brain decreases, and heat transfer increases.
1st generation NSAIDs have a non-selective effect on COX. This group of drugs includes paracetamol, ibuprofen, acetylsalicylic acid, phenylbutazone and others.
These substances inhibit the production of both COX-1 and COX-2. Due to this, many side effects occur. Among which the most common manifestations are oliguria, bronchospasm, exacerbation peptic ulcer stomach and duodenum, disturbances in the functioning of the gastrointestinal tract, kidneys and liver.
Important:
If a high temperature in an adult lasts no more than 2 days, it is most advisable to take Paracetamol (also belongs to the group of analgenics-antipyretics). This is the only drug that acts directly on the thermoregulation center.
The drug is based on paracetamol and belongs to the anilides group. It has an analgesic, antipyretic, and mild anti-inflammatory effect.
As a monotherapy, it is acceptable to take it for pain of minor intensity (headache, dental, muscle, menstrual pain), to reduce body temperature above 38.5 against the background of ARVI and influenza.
The drug is contraindicated in case of hypersensitivity to the main active ingredient, severe impairment of the kidneys, liver, deficiency of the enzyme glucose-6-phosphate dehydrogenase, any blood diseases, children under 9 years of age weighing less than 35 kg.
Patients with Gilbert's syndrome, pregnant women and during lactation should take Panadol with extreme caution.
Side effects most often include disturbances in the functioning of the gastrointestinal tract, hepatotoxicity, thrombocytopenia, leukopenia, agranulocytosis, allergic reactions in the form of skin rash, itching, and urticaria.
Adults are recommended to take 1-2 tablets. no more than 4 times a day, and the interval between doses should be at least 4 hours. You should not take Panadol for more than 5 days as a pain reliever and no more than 3 days as an antipyretic.
The soluble form of tablets allows minimizing negative impact on the mucous membranes of the gastrointestinal tract. In addition, the speed of onset of the antipyretic effect is higher: a decrease in temperature is observed after 20 minutes.
Advantages of paracetamol-containing drugs:
Flaws:
The drug without paracetamol - contains ibuprofen, which is a derivative of phenylpropionic acid. Shows good analgesic, antipyretic, anti-inflammatory activity.
The main indications for use of the drug are headache/toothache, migraine, neuralgia, myalgia, arthralgia, rheumatism, manifestations of influenza and ARVI, increased body temperature of any origin.
Contraindications to the use of Nurofen are gastric ulcers, pathologies of cardio-vascular system, including heart failure, arterial hypertension, hypersensitivity to other NSAIDs, visual impairment, glucose-6-phosphate dehydrogenase deficiency, any type of hemophilia, leukopenia, kidney disease, liver disease.
Side effects include dyspeptic disorders, sensitization reactions, Stevens-Johnson and Lyell syndromes, headaches, dizziness, sleep disturbances, tachycardia, increased blood pressure.
Advantages:
Disadvantages: wide list of contraindications and side effects.
It belongs to the group of NSAIDs, but in addition to the anti-inflammatory and antipyretic effect, it stimulates the production of interferon.
The anti-inflammatory effect is due to the ability to inhibit the production of inflammatory mediators and reduce the activity of lysosomal enzymes.
Mefenamic acid stabilizes protein structures cell membranes, reduces their permeability, increases the resistance of cells to the effects of foreign agents. The antipyretic effect is associated with inhibition of prostaglandin synthesis and an effect on the thermoregulatory center of the hypothalamus.
The drug is recommended in complex therapy ARVI and influenza, to relieve pain from muscle, joint, headache, toothache, and diseases of the musculoskeletal system of inflammatory origin.
Contraindications for use are hypersensitivity to the components of the drug, a history of bronchospasm, Quincke's edema, urticaria after using other NSAIDs, peptic ulcer of the stomach and/or duodenum, diseases of the hematopoietic organs, heart failure.
You need to take the drug 250-500 mg no more than 4 times a day, washed down with milk. If necessary, the daily dose can be increased to 3000 mg, after which it is gradually reduced to 1000 mg.
Advantages:
Flaws:
In addition, it is possible to receive acetylsalicylic acid(Table No. 10 - about 9 rubles), analgin (Table No. 10 - 15 rubles). However, these drugs often provoke the development of serious side effects.
In addition, aspirin should not be taken to reduce fever during influenza and ARVI, since it can provoke the development of internal bleeding.
For cupping side effect Can you take acetylsalicylic acid tablets with alkaline tablets? mineral waters, but this significantly reduces the effectiveness of the drug.
Metamizole sodium
, or analgin, is banned in many countries. This is due to the fact that monotherapy with this drug provokes the development of rapid sensitization reactions (allergy).Also, clinical trials have proven that metamizole sodium helps reduce the number of white blood cells, and this leads to a decrease in the body’s resistance to the effects of viruses and pathogenic microorganisms.
2nd generation antipyretic drugs have been developed over the past 20 years. They selectively affect COX-1 or COX-2, which has reduced the list of contraindications and side effects, but their negative impact on heart function has been proven.
In addition, their intake does not depend on food intake.
Antipyretics for high temperature from this group are represented by drugs containing nimesulide (Nise, tablet 100 mg No. 20 - 190 rubles, Nimesil, pack of 2 g No. 30 - 680 rubles) and meloxicam (Movalis, tablet 15 mg No. 10 - 675 rubles).
Exhibits analgesic, antipyretic, proinflammatory effects. Used as a strong antipyretic for adults, pediatric practice prohibited.
Prescribed primarily as an anti-inflammatory drug for rheumatoid arthritis, articular syndrome during exacerbation of gout, psoriatic arthritis, osteochondrosis, myalgia.
Contraindicated in pronounced violations kidney function, hypersensitivity to nimesulide, gastric ulcer. Prescribed with caution when increasing blood pressure, heart failure, type 2 diabetes. The most common side effects are skin allergic reactions.
As an antipyretic, it is recommended to take 50-100 mg up to 2 times a day. The course of admission is no longer than 3 days. The advantage of Nise is its release form - sublingual tablets. That is, the drug dissolves in the mouth and has a pleasant sweetish taste.
Allows you to reduce Negative influence on the gastric mucosa, and the antipyretic effect occurs faster. However, it is available in powder form and the need to dissolve the contents of the sachet may cause some inconvenience to the patient.
Movalis and other drugs containing meloxicam are rarely used as antipyretics. However, like other NSAIDs, they are quite effective and quickly reduce body temperature.
Movalis is available in the form of tablets and suppositories. Suppositories are more effective, since the rectal route of administration allows achieving a therapeutic effect within 15 minutes.
Combined antipyretic drugs have a complex effect, due to which it is possible not only to reduce body temperature, but also to improve the general well-being of the patient.
The list of such drugs is as follows:
Ibuklin is a strong antipyretic, contains paracetamol and ibuprofen, due to which it effectively reduces hyperthermia during influenza and acute respiratory viral infections, and quickly eliminates headaches, toothaches, and muscle pain.
You should take 1 tablet. no more than 3 times a day. Contraindicated for gastric ulcers, renal and liver failure, blood diseases, bronchial asthma, polyposis.
Aspirin-C combines acetylsalicylic and ascorbic acids. It is applied for symptomatic treatment pain of moderate and moderate intensity, decrease in body temperature above 38 degrees.
The drug is contraindicated for diseases of the gastrointestinal tract, blood, liver and kidney pathologies, a history of bleeding of any etiology, and vitamin K deficiency.
You should take 1-2 tablets, which are dissolved in 100 ml of water. The maximum daily dose is 6 tablets.
Coldact Flu Plus effectively reduces temperature, eliminates nasal congestion, and improves the general well-being of the patient. Contains paracetamol, phenylephrine, chlorpheniamine. The drug should be taken one capsule every 12 hours.
They also have a similar composition Rinza and Coldrex. Rinz tablets should be taken up to 4 times a day. Coldrex, in addition to the indicated components, contains caffeine, terpene hydrate, and ascorbic acid. Such complex composition Helps effectively reduce fever against the background of influenza and ARVI.
Important:
It should be borne in mind that all combined antipyretic drugs have more wide list contraindications and possible side effects in contrast to monocomponent ones.
Among the many antipyretic drugs for pregnant women Paracetamol or its analogues are allowed only as prescribed by a doctor. It belongs to the group of analgesics-antipyretics that affect the thermoregulation center. Paracetamol also effectively fights headaches and toothaches.
The permissible dose for pregnant women is one tablet no more than 3 times a day. However, it must be taken into account that an overdose and long-term use The drug can provoke the development of attention deficit disorder and neurological disorders in the unborn child.
Can be recommended for pregnant women as an antipyretic Viburkol candles. It's complex homeopathic remedy, exhibiting analgesic, anti-inflammatory, sedative, antispasmodic, antipyretic effects.
The drug is used in the complex therapy of acute respiratory viral infections, influenza, convulsive syndrome, nervous overexcitation, inflammatory diseases ENT organs, pathologies genitourinary organs inflammatory genesis.
In acute cases of the disease, it is allowed to use suppositories every 20 minutes for 2 hours. After this they put 1 supp. no more than 3 times a day. The duration of therapy is no more than 2 weeks.
The most common side effect is hypersensitivity to the components of the drug.
Important:
Any medications during pregnancy should be taken only as prescribed by a doctor. Only a specialist will be able to balance the potential risk for the developing fetus and the benefits for the expectant mother.
Main alternative method To reduce the temperature, drink plenty of warm drinks. An adult should drink at least 2 liters of water per day. Thanks to this, metabolic processes in the body are accelerated and pathogenic microorganisms, viruses and their metabolic products are eliminated faster.
On the forehead, groin area, inner side Apply cold compresses, such as a wet towel or ice packs, to the elbows (where large veins emerge) and remove them every 10 minutes to prevent hypothermia.
These methods can only be used if the body temperature rises no more than 39 degrees. Otherwise, you should immediately call a doctor.
Antipyretic drugs are one of the most popular medications, since almost every person experiences an increase in temperature. The variety can be confusing, and some popular pills are illegal in other countries. Before deciding on the choice of medication, you should understand in what cases it is necessary to take it.
It is not always necessary to take antipyretic pills. Fever is a natural reaction of the body to an irritant. At the same time, the human body produces interferon, which helps it fight the virus. Drugs to reduce fever do not affect the healing process, but only eliminate some manifestations of the disease.
If it is possible to spend several days in a gentle mode, alleviating the condition only by physical methods exposure (drinking plenty of fluids, ventilating the room, cooling compresses), it is better to stop taking medications. The body itself will be able to cope with a cold.
But there are cases in which antipyretics are necessary:
If antipyretic drugs, the list of which is quite extensive today, do not help within an hour, then you need to seek emergency help.
Drugs that can reduce fever, relieve pain, and reduce inflammation are nonsteroidal anti-inflammatory drugs (NSAIDs). They are non-hormonal and act by inhibiting the two-part enzyme cyclooxygenase. It is responsible for the production of substances that signal the thermoregulation center about the need to increase the temperature.
NSAIDs are divided into two categories of drugs:
As the use of antipyretics increases, the risk of side effects also increases. The medicine should be taken only after the temperature rises, and not in order to avoid it.
It is better to take monocomponent medications: they are more easily absorbed by the body and cause fewer adverse reactions. But you cannot use other drugs containing the same active ingredients in parallel, as this will increase their dosage. In medical practice The most common are first-generation NSAIDs, based on one of the following substances:
Antipyretic suppositories for adults are used in cases where taking drugs orally is difficult due to various reasons. The most popular among them are the following:
Compared to tablets, antipyretic suppositories act much faster and most often do not have a negative effect on the gastrointestinal tract.
Antipyretics for children are used only in extreme cases due to the presence of side effects. But if taking them is necessary, then you should know which type of drug is preferable. Children's medications have several forms of release:
The child may also be allergic to the main substance of the drug. Therefore, before giving children an antipyretic, you should consult your doctor. The mandatory break between taking medications is 4 hours.
As in adults, antipyretic drugs for children are NSAIDs with various active ingredients in their composition. The following drugs are available for children: analgin, amidopyrine, aspirin, butadione, voltaren, ibuprofen, indomethacin, naproxan, nimesil, paracetamol. But most of these drugs have a negative effect on critical systems body.
Prohibited antipyretic drugs for children, the list of which includes acetylsalicylic acid, antipyrine, metamizole sodium, amidopyrine, nimesulide, phenacetin, can lead to severe impairment internal organs and even fatal outcome. Before the purchase children's drug to reduce fever, you should carefully study its composition, since a large number of drugs contain the listed components, but are presented under different names.
The main antipyretics for children are paracetamol and ibuprofen. Their effect is weaker than other drugs, but they are safer. The combined drug ibuklin, which includes both substances, is prescribed for diseases unknown etiology. The usual dosage is up to 15 mg/kg of the child’s weight. But each case is individual, and the doctor’s instructions should be followed. Features of taking these drugs:
Antipyretic suppositories for children are produced on the basis of paracetamol, ibuprofen and analgin. They have more long action than tablets or syrup. Sometimes the doctor prescribes the first dose of the drug in the form of syrup, and the next - suppositories to prolong therapeutic effect. In addition to NSAIDs, homeopathic viburkol suppositories are also used, which are aimed at reducing pain and temperature.
All antipyretic drugs have side effects. Therefore, it is better to do without them. But when taking medications is unavoidable, you should use the most harmless ones and carefully follow the instructions.
Elevated body temperature is the body's protective reaction to the penetration of infectious agents. Each of us has encountered a similar condition, so antipyretics for adults can be called the most popular medications that are literally swept off pharmacy shelves during the flu and cold season.
However, do not forget that you should not lower the temperature to a certain limit, since this is how the body resists infection. But in cases where the patient’s well-being worsens, and high temperature aggravates the condition and threatens the development of complications, it is necessary to fight it. How to choose the right drug among the wide range of antipyretic drugs presented on the shelves of pharmacies? Our review will help you with this, in which we will tell you about the features, properties and methods of using the most popular medications.
How do fever medications work? When the temperature rises in the patient’s body, the formation of prostaglandin E (an active mediator of inflammation) begins, which is main reason feverish condition. Antipyretics interrupt this entire process and inhibit the synthesis of prostaglandin, as a result of which body temperature decreases.
All antipyretic drugs for adults can be divided into nonsteroidal anti-inflammatory drugs (NSAIDs) and opioid analgesics. The list of antipyretic drugs is extensive; NSAIDs alone are currently represented by 15 groups of drugs. Each remedy has its own characteristics and differs in the degree of analgesic, antipyretic and anti-inflammatory effect. After their appearance on the pharmaceutical market, NSAIDs quickly replaced opioid analgesics, due to the fact that drugs in this group had fewer dangerous side effects associated with respiratory depression. Let's take a closer look at the representatives of this group of drugs.
Antipyretic NSAIDs are divided into two categories:
Doctors recommend that adult patients take single-component medications to reduce fever. Such drugs act faster and are better absorbed. Of course, when taking it, you must follow the recommended dosages and do not combine drugs with similar action to prevent overdose. Statistics show that doctors more often prescribe first-generation antipyretic drugs to adult patients.
Antipyretics are produced in different dosage forms ah: in the form of tablets, capsules, injection solutions, syrups, suspensions, rectal suppositories. Suppositories and sweet syrups are usually prescribed to young patients. For adults, it is preferable to take drugs in tablet form. IN severe cases, when the temperature rises to pathological values, injection solutions are used; they act faster and more efficiently than their analogues.
In other cases, adult patients are prescribed antipyretic tablets. Let's take a closer look at the properties and method of use of the most popular drugs:
Koldakt has quite a lot of contraindications. These are atherosclerosis of the arteries, hypertension, pathologies of the kidneys and liver, glaucoma, diabetes mellitus, heart disease, ulcerative lesions of the gastrointestinal tract, hypersensitivity, pregnancy, lactation, etc. The drug may cause side effects from various systems body, therefore it should be taken as prescribed by a doctor and not exceed the indicated dosages. The price of the medicine is from 175 rubles.
Any antipyretic drugs do not eliminate the cause of the disease, but only stop individual symptoms diseases and improve overall well-being. Therefore, if you have the opportunity to observe for 2-3 days bed rest, give up antipyretic drugs in favor of classical methods treatment: cold compresses, ventilation of the room, plenty of hot drinks with honey, lemon and medicinal herbs.
At low-grade fever(37-37.5°), there is no need to take antipyretic drugs. If your health worsens and the temperature rises above 38.5°, you must call a doctor and follow his recommendations. Antipyretic drugs should be taken in the following cases:
If, after taking antipyretic drugs, the patient’s body temperature drops to normal values, you should not give him a second dose until the thermometer rises again. If the temperature does not return to normal within 1 hour, you should consult a doctor.
When taking antipyretics, give preference to single-component drugs, since the use of beautiful packaged medications can cause a number of negative consequences and side effects. The reason for this is an overdose. To avoid dangerous complications, it is best to let the body fight the disease on its own. It must be remembered that while taking a multicomponent drug, you cannot take other medications. When the body takes one drug, it needs much less energy to absorb it, so you should not overload it with harmful dyes and preservatives that contain packaged products intended for preparing hot drinks.
Quick relief after taking antipyretic drugs in bags often leads to the fact that a person begins to perceive it as a safe medicinal drink, forgetting that the drug contains strong active ingredients. To avoid overdose, taking any antipyretic drug should not continue for more than three days in a row without consulting a specialist.
We should not forget about many serious illnesses, entailing severe consequences. After all, taking antipyretic drugs distorts clinical picture and makes it difficult to make a correct diagnosis. This results in the doctor being unable to understand the exact cause of your condition and assess the severity of the disease. Another limitation concerns the use of antibiotics. If your doctor has prescribed them, you should not combine these medications with antipyretic drugs.
Thus, despite the availability of a wide range of medicines designed to combat fever and fever, it is dangerous to use them uncontrollably. In any case, a preliminary consultation with your doctor is necessary; you should not self-medicate.
An increase in body temperature means the body is demonstrating a protective reaction to infection. Anyone has encountered this, which is why antipyretic drugs for adults are considered one of the most popular medications.
As you know, body temperature cannot be reduced to a certain point, because... This is how the body fights infection. However, in cases where the patient’s well-being deteriorates, high temperature leads to a worsening of the condition and the development of complications, which is why these remedies are so necessary.
This review presents all the most effective antipyretic drugs, as well as the available features, properties and methods of using these drugs.
Let's figure out how fever remedies work. Increased body temperature of the patient leads to the formation of prostaglandin, which is an active mediator of inflammation and leads to a febrile state. Antipyretic drugs stop this process and prevent the synthesis of prostaglandin, thereby reducing body temperature.
All antipyretic medications for adults are divided into opioid analgesics and nonsteroidal anti-inflammatory drugs (NSAIDs). There are a lot of antipyretic drugs, only NSAIDs are now divided into 15 groups of drugs. Each drug has its own characteristics and differs in the degree of antipyretic, analgesic and anti-inflammatory effect.
After going to pharmaceutical market NSAIDs have quickly eclipsed opioid analgesics due to fewer dangerous side effects associated with respiratory functions. It is NSAIDs that we will dwell in more detail on.
Antipyretic NSAIDs divided into 2 categories:
Doctors advise adult patients to drink single-component drugs to lower the temperature, because they act faster and are easier to digest. Of course, it is important to follow the required dosage when taking it and not use others. similar drugs, because this is fraught with overdose. According to statistics, adult patients are more often prescribed 1st generation antipyretic drugs.
These funds are dispensed in the form of:
Sweet syrups and suppositories are usually prescribed to young patients. Adults are recommended to take medications in tablet form. If the temperature rises to critical values, then use injection solutions, because they act more efficiently and faster than their counterparts. In all other cases, adult patients use antipyretic medications in tablets. Next, we will consider in more detail the method of use and properties of the most famous drugs.
The drug has a pronounced analgesic and antipyretic effect. On inflammatory processes This medication is not effective enough. According to patient reviews, these antipyretic tablets quickly reduce fever.
Paracetamol has no flavors or dyes, which are contained in antipyretic powders for making a hot drink. 500 mg is the recommended dose of paracetamol for adults. The daily dose is no more than 4 grams, because its active substance can lead to undesirable adverse reactions from the nervous and digestive system. Contraindications to the use of this remedy: liver and kidney diseases, individual intolerance, chronic alcoholism. The average cost of paracetamol is 17 rubles.
Is strong combination drug long-acting, intended for the treatment of ARVI and influenza. It has powerful analgesic properties, fights rhinorrhea, fever and feverish conditions. The drug is based on paracetamol, phenylenephrine and chlorphenamine. Paracetamol reduces fever, relieves pain, relieves muscle, joint and headache pain. Chlorphenamine does not cause allergic reactions, eliminates irritation and itching of the mucous membranes, and eliminates lacrimation. Phenylephrine helps to constrict blood vessels and reduce swelling of the mucous membranes of the nasopharynx and respiratory tract.
Koldakt has many contraindications, including: atherosclerosis of the arteries, glaucoma, hypertension, liver pathologies, heart disease, diabetes mellitus, gastrointestinal ulcers, pregnancy, lactation, hypersensitivity, etc. This remedy can cause side effects from many systems of the body and therefore you should use it exclusively as prescribed by a doctor and drink only according to indicated dosages. Cost of the medicine - from 175 rubles.
The drug is available in the form of tablets and powder (Coldrex Hotrem). The medicine contains paracetamol, caffeine and ascorbic acid. Coldrex quickly reduces body temperature, relieves pain and cold symptoms: nasal congestion, runny nose. You should not take the drug for more than five days in a row. This is the remedy has many contraindications. These are glaucoma, alcoholism, heart disease, kidney disease, liver disease, diabetes mellitus, etc. Before use, you should definitely consult a doctor, including to clarify the dosage of the medication. The average cost of Coldrex is around 163 rubles.
All antipyretic medications do not affect the cause of the disease, but only block individual symptoms of the disease and help relieve general well-being. Therefore, if it is possible to comply bed rest for 2-3 days, then in this case you need to abandon antipyretics in favor of cold compresses, ventilation of the room, plenty of hot drinks with honey, lemon and medicinal herbs.
Low-grade fever (37-37.5°C) does not require the use of antipyretics. If your health worsens and your temperature rises above 38.5°, you should call a doctor and follow his recommendations. Taking antipyretic medications is advisable in the following cases:
If the patient's temperature drops to normal levels due to taking antipyretics, a repeat dose should not be given until a subsequent increase in body temperature. If the temperature has not returned to normal after 1 hour, then you need to consult a doctor.
When using antipyretic medications, preference should be given to single-component drugs, because taking beautiful packaged products can lead to negative consequences and side effects caused by overdose. To avoid dangerous complications, it is advisable to give the body time to fight the disease.
It is important to remember that taking a multicomponent drug excludes the possibility of using other medications. When the body takes one product, much less energy is spent on absorption, so do not overload it harmful additives contained in packaged products intended for preparing a hot drink. Antibiotics should not be taken together with antipyretic drugs.
From all of the above, it follows that the presence large quantity medicines produced to get rid of fever and heat, does not mean the possibility of their uncontrolled use. First of all, it is important to first consult with a specialist, but you should not engage in treatment.
Attention, TODAY only!
The temperature rises because the body “heats up” to cope with the intruders. pathogens. This is a protective reaction and often helps with mild infections. If the high temperature lasts for a long time, it becomes dangerous, it is necessary to use antipyretic drugs.
Many people take medications to bring down a fever immediately after cold or flu symptoms appear, but this is not true. Indications for taking antipyretic drugs, according to the instructions, are:
Contraindications to the use of antipyretics for adults:
Side effects may occur when taking anti-inflammatory drugs to reduce fever:
All antipyretic drugs available in pharmacies for high fever in adults are divided into first and second generation drugs. First generation drugs include drugs with a non-selective effect on cyclooxygenase. These products contain:
Second-generation drugs for adults selectively act on enzymes, which reduces the number of side effects. The downside is that it has been noted that they often have a negative effect on the heart. These include antipyretics containing:
On sale you can find suppositories, syrup, suspension, and fever tablets for adults. The advantage of oral dosage forms is ease of use, while rectal forms have the advantage of quickly achieving effect. Antipyretic tablets, syrups and suspensions should not be taken for longer than 3-5 days, while suppositories can be used for 10-14 days.
Efferalgan | ||
Action | Relieves pain, relieves fever | Anesthetizes, relieves fever, relieves inflammation |
Method of administration | Orally, dissolved in a glass of water, no more than 1-2 tablets per day after meals | 1 tablet up to 4 times a day, orally |
Side effects | Nausea, vomiting, allergies, anemia, urticaria, leukopenia, methemoglobinemia, agranulocytosis, thrombocytopenia, pancytopenia | Skin rashes, itching, anemia, renal colic, nonspecific bacteriuria, interstitial nephritis, papillary necrosis, thrombocytopenia, methemoglobinemia, Quincke's edema |
Cost, rubles | 185 for 16 tablets 500 mg | 50 for 12 tablets 500 mg |
Ibuprofen |
||
Action | Inhibits the synthesis of prostaglandins, suppresses the activity of the enzyme cyclooxygenase | Relieves pain, fever, inflammation, suppresses platelet aggregation, has a desensitizing effect |
Method of administration | Orally, 200 mg 3-4 times a day | Orally, 200-800 mg 3-4 times a day |
Side effects | Nausea, vomiting, heartburn, increased blood pressure, anorexia, diarrhea, flatulence, dizziness, tachycardia, edema, anemia, bronchospasm | Insomnia, aseptic meningitis, nausea, vomiting, heartburn, bronchospasm, urticaria, edema, depression, anorexia, diarrhea, gastropathy, tachycardia, itchy skin, anemia |