Comparison of the main diuretic drugs (Indapamide, Diuver, Espiro, Diacarb, Hypothiazide, Triampur Compositum, Lasix) with Veroshpiron. Brief description of the drug. Key differences and effectiveness

Diuretic drugs are prescribed for pathologies of the excretory, of cardio-vascular system, also some diseases of cerebral structures for unloading the body, evacuation excess liquid, recovery electrolyte balance. The use of many drugs in this group leads to the excretion of potassium and magnesium, which leads to cardiac problems.

According to studies by European medical associations, products based on spironolactone are considered the safest and most effective. In Russia and the CIS countries, two commercial versions of the product are very popular: Verospiron (Hungarian) and the analogue Spironolactone (made in Russia). Accordingly, it makes sense to compare other drugs of this pharmaceutical group with them.

The diuretic activity of Veroshpiron is due to the presence of spironolactone in the active substance. Main indications for use of the product:

• edema of any origin (against the background of congestive heart failure, pathologies of the kidneys, liver);
• essential hypertension (primary, caused by cardiac causes);
• hydrocephalus and increased intracranial pressure;
• cerebral edema (with drug intolerance emergency action);
• increased secretion of aldosterone by the adrenal glands.

IN following cases the drug cannot be used:

• under three years of age;
• during lactation;
• pregnancy at any stage;
• Addison's disease or adrenal hormone deficiency;
• excess potassium in the body;
• deficiency of sodium compounds;
• renal failure in the phase of decompensation or subcompensation;
• symptomatic oliguria or anuria, disruption of urine production (less than 500 ml per day).

Veroshpiron should be used strictly according to indications. Uncontrolled reception medicines diuretic effect increases the impairment of the filtering function of the kidneys.

Diuretics are not used for weight loss.

Representatives of the group of diuretics

Let's take a closer look at the following medications and their combinations:

• products based on spironolactone (Veroshpiron, Spironolactone);
• indapamide preparations (Indapamide, Indap);
• drugs torasemide (Diuver, Trigrim);
• products based on eplerenone (Espiro, Inspra);
• acetazolamide agents (Diacarb);
• hydrochlorothiazide (Hypothiazide);
• furosemide (Lasix)
• triamterene + hydrochlorothiazide (Triampur Compositum).

Each of them has its own activity and area of ​​primary application.

Which is better, Veroshpiron or Indapamide?

The latter contains a substance of the same name, which determines the pharmaceutical activity of the drug. Its main difference from a product based on spironolactone is the lack of selectivity. Indapamide also does not conserve potassium and magnesium, which makes it dangerous when used in the treatment of cardiac problems.

In addition, there is a higher chance side effects. Mainly from the heart and blood vessels. Tachycardia, headache, vertigo, arrhythmias of a different nature. Against the background of severe cardiac abnormalities (extrasystole, coronary insufficiency, atrial fibrillation), use is not recommended. Otherwise, the contraindications are identical. Use in children is not possible. Indapamide is often prescribed for the treatment of early forms hypertension and isolated systolic hypertension.

Diuver and Veroshpiron

These are diametrically opposed drugs with their own areas of application. Veroshpiron has a mild diuretic effect. Therapeutic activity is achieved only 3-5 days after the start of use, so the use of spironolactone-based products is not practiced in emergency conditions. Diuver (other trade name- Trigrim) begins to act after 1.5-2 hours. The effect is strong and long lasting. Potassium and magnesium are excreted from the body, but in small quantities. Frequently side effect turns out to be a spasm calf muscles, convulsions.

Combined use is practiced to eliminate cardiac pathologies, also in the treatment of advanced arterial hypertension on the rights complex therapy. Diuver or Veroshpiron, which is better? The question is incorrect, this different drugs, although they belong to the same pharmaceutical group.

Espiro or Veroshpiron

Clinical studies have not shown significant differences between these two drugs. Moreover, eplerenone is a modern analogue of spironolactone.

The only significant difference between the drugs is the more active effect of Espiro on aldosterone. Scope of application: hypertension, congestive heart failure. Espiro is a highly specialized drug, Veroshpiron is more universal. Espiro or Veroshpiron, which is better? Depends on the severity of the heart pathology. Determined by the clinical situation.

Veroshpiron and Diakarb

Approximately the same clinical effect. Both drugs are used to treat many pathologies of various kinds. Both preserve potassium and magnesium and do not have a destructive effect on the heart muscle. Studies have shown that Veroshpiron is more effective in the presence pulmonary diseases(edema and others). Both are ineffective against ophthalmic emergencies.

Which is better, Veroshpiron or Diakarb? Both are relatively weak and safe. Used for a moderate, stable diuretic effect.

Hypothiazide or Veroshpiron

Hypothiazide is considered more a powerful drug emergency action. Therefore, the main difference from Veroshpiron is the ability to relieve emergency conditions. Veroshpiron is practically useless against cerebral edema and other abnormalities. Use is only possible in case of intolerance to spironolactone.

Veroshpiron or Hypothiazide, which is better? Depends on the clinical situation and the main diagnosis. Shared use is possible, but then the risk of hypotension, bradycardia, and arrhythmic phenomena is higher.

Triampur Compositum or Veroshpiron

Triampur Compositum is combination drug with two diuretic substances in its composition. It is more focused on therapy renal pathologies, acts more softly. It is practically useless in relation to pathologies of cardiac structures and other non-renal diseases. Exceeding the dosage of one or another drug leads to disruption of the excretory system and potentially fatal complications.

Which is better, Triampur or Veroshpiron. The first is more effective regarding pathologies of the urinary tract, the second in all other cases.

Veroshpiron and Lasix

Lasix (furosemide) is an emergency drug. It is much more powerful, but the action is non-selective. There are many more side effects; the consequences of long-term use are potentially dangerous. The main area of ​​application of Lasix is emergency conditions of any nature. It is important to observe the principle of expediency; unless absolutely necessary, furosemide-based products are not used.

Features of use with beta blockers and restorative drugs

Basically, the prescription of diuretics is carried out with these drugs. Thus, when used together with Concor (a combined beta blocker with antiarrhythmic properties), an increase in the pharmaceutical effect is observed. The dosage must be strictly observed. Otherwise it is possible severe hypotension, sleep problems, polyuria, bradycardia.

On the background joint use with Panangin, Asparkak, Magne B6 and other means, an excess of microelements in the body is possible. Rehabilitation therapy is carried out under constant monitoring of laboratory parameters.

Other antihypertensive agents are compatible with Veroshpiron. You should not take medicine with cardiac glycosides. Use with caution with acetylsalicylic acid(Aspirin and Aspirin Cardio).

Conclusion

Each described diuretic has its own pros and cons; it is difficult to compare Veroshpiron with other drugs, since there are few equivalent ones in terms of effectiveness and scope of application. The last word remains with the attending physician, urologist, nephrologist, cardiologist in case of pathologies of the cardiovascular system.

Video: Live healthy! Diuretics - what to ask your doctor about. (06/21/2016)

The causes of edema are different. These may be chronic diseases of the liver, kidneys and lungs, acute heart failure, increased arterial pressure. They arise due to overuse water, during pregnancy or as a consequence allergic reaction. Diuretics not only relieve unpleasant symptoms, but also play vital role in the treatment of diseases of various origins. They remove excess fluid, toxins and salts accumulated in the tissues and walls of blood vessels, normalize blood pressure, and eliminate swelling.

Expected therapeutic effect depends on the right choice diuretic, as they differ in their mechanism of action. To choose the best diuretic drug, you need to familiarize yourself with the following characteristics:

1. Compound. All diuretics are divided into synthetic, semi-synthetic and natural. Plants gently remove excess fluid from the body. Medicines with a chemical composition act quickly and have a long-lasting effect.
2. Product type. They are divided into strong, medium and weak. The former contribute to the rapid outflow of water and the elimination of swelling. They are prescribed for the treatment of various diseases. Medium and weak drugs are indicated for swelling of the hands and feet. They are approved for use by pregnant women, children and the elderly. Such medications do not act immediately, sometimes for 2-3 days.
3. Manufacturer. High quality medical supplies produced by large pharmaceutical companies. Pay attention to the manufacturer to avoid purchasing an ineffective product.
4. Contraindications. You should not use the drug if the instructions contain at least one reason prohibiting its use. It is necessary to abandon it completely and consult a doctor to choose a safe and effective remedy.

• expert opinion;
• effectiveness of the drug;
• safety for the body;
• patient reviews;
• value for money.

Do not forget that before using any medications, you should first consult your doctor!

There are contraindications. Consult your doctor.

The best diuretics for weight loss

Excess weight is a serious problem that every third person in the country faces. There are many ways to get rid of it. Taking diuretics is especially popular. They help remove excess fluid and salts from the body, thereby getting rid of the hated kilograms. But it is worth remembering that using diuretics alone will not lead to lasting results. Only in combination with proper nutrition and physical activity can normalize your weight.

4 Indapamide

Strong diuretic effect
Country: Serbia
Average price: 90 rub.
Rating (2019): 4.6

Indapamide tablets are a moderate diuretic. It is used as a drug that relieves edema caused by acute heart failure. It is quickly and completely absorbed from the gastrointestinal tract. The tablets contain an active substance that reduces the load on the heart and peripheral vascular resistance, and normalizes blood pressure.

After administration, the effect occurs within 60 minutes and lasts from 12 to 18 hours. When using the drug when losing weight, it is important to remember that excess weight is lost as a result of the excretion of water, and not subcutaneous fat. Only complex methods will lead to the desired result. Advantages: great diuretic effect, possible long-term use, rapid loss of excess fluid, low price. The disadvantages include the presence of contraindications.

3 Veroshpiron

Excellent potassium-sparing agent
Country Russia
Average price: 100 rub.
Rating (2019): 4.7

"Veroshpiron" refers to potassium-sparing diuretics. It is indicated for use in edematous syndromes caused by chronic heart failure and diseases endocrine system. The diuretic effect is mild, but the drug does not cause potassium loss and does not lead to acid-base imbalance in the body. Its maximum effect occurs after 2-3 days and lasts for a long time. After using the product, blood pressure decreases and swelling disappears.

By combining pills with other weight loss methods you can get rid of excess weight and achieve lasting results. Advantages: mild diuretic, safe for health, does not wash away potassium, normalizes blood pressure, long-lasting effect, low price. No cons found.

2 Furosemide

The most potent drug
Country Russia
Average price: 30 rub.
Rating (2019): 4.8

Furosemide is the most common and popular diuretic. It belongs to the group of strong diuretics. The drug quickly removes excess fluid and sodium salts from the body. The drug lowers blood pressure, eliminates edema caused by diseases of the liver, heart and kidneys. As a result of water loss, significant and rapid decline weight. But to consolidate the weight loss effect, an integrated approach will be required.

The effect of the tablets begins in 20-30 minutes and lasts up to 6 hours. According to patient reviews, this best medicine, helping in critical situations. Pros: strong diuretic effect, effective in severe swelling, fast weight loss, low cost. Disadvantages: long-term use without medical supervision can lead to dehydration.

1 Hydrochlorothiazide

Better elimination of edema
Country Russia
Average price: 80 rub.
Rating (2019): 4.9

A drug Russian production is an effective diuretic, perfectly removes excess fluid and sodium salts from the body. It is used for diseases of the liver, heart, lungs and kidneys to eliminate edema, and helps lower blood pressure. The drug does not form metabolism in the body and is excreted unchanged through the kidneys.

The maximum effect is achieved 4 hours after application. The action lasts up to 12 hours. According to reviews, the medicine quickly removes water, thereby leading to the loss of extra pounds. Lasting results appear when integrated approach to the problem of losing weight. Advantages: excellent diuretic, loss overweight, removes swelling of various origins, optimal price. No deficiencies found.

The best diuretics for the face

Each of us has faced the problem of facial swelling and the appearance of bags under the eyes. In some cases, this manifests itself in the form of slight puffiness in the cheekbones, in others – the face swells completely. The causes of edema are different. This may be the consumption of excess liquid drunk the day before, and serious illnesses kidneys, heart or liver. The main thing is to identify the cause of the symptoms. First aid will be provided by diuretics, which will quickly and effectively cope with swelling.

4 Phytonephrol

Best cast
Country Russia
Average price: 80 rub.
Rating (2019): 4.6

The urological product is produced in the form of crushed fruits and herbs, packaged in filter bags. Natural ingredients have an invaluable effect on the body during complex therapy chronic diseases kidneys and urinary tract. Bearberry leaves contain enzymes that clear bacteria and viruses. Calendula flowers have anti-inflammatory and diuretic effects. Eleutherococcus root strengthens, restores immunity, and normalizes metabolism.

Peppermint is an excellent antispasmodic and analgesic. Dill seeds contain essential oils, which effectively influence the removal of excess fluid from the body. Advantages: 100% herbal composition, safe remedy, copes well with facial swelling, optimal price. No cons found.

3 Torasemide

Longest lasting action
Country Russia
Average price: 120 rub.
Rating (2019): 4.7

"Torasemide" is one of the most effective diuretics to date. It has a diuretic and saluretic effect. The drug is indicated for acute, chronic cardiac and renal failure. It is also used as prophylactic from the appearance of edema. In case of hypertension, it reduces blood pressure as a result of the rapid removal of sodium salts and water from the body.

The product begins to act in 50-60 minutes. After 2 hours, the maximum effect is achieved, which lasts from 12 to 18 hours. According to reviews, the advantage of the drug is that increased urination does not occur immediately. This does not limit the patient’s activity in the first hour after administration. Advantages: long-lasting action, quick fix swelling of the face, reduces blood pressure, optimal price. Minus: there are contraindications.

2 Uregit

Rapid fluid removal
Country: Hungary
Average price: 1900 rub.
Rating (2019): 4.8

The drug is a fast-acting diuretic. It removes chlorine, sodium and water ions from the body. The medicine is indicated for use in cases of edema resulting from diseases of the kidneys, heart, brain and lungs. It is also effective in cases where other drugs do not help. The active substance, ethacrynic acid, inhibits the reabsorption of sodium. Therefore, the tablets can be taken by patients with kidney failure.

The product begins to act 30-40 minutes after administration. The maximum effect is achieved after 2 hours and lasts from 6 to 9 hours. According to reviews, “Uregit” is a mild diuretic that has a pronounced effect and does not cause side effects. Advantages: rapid removal of fluid, excellent for facial swelling, moderately lowers high blood pressure. The disadvantages include high cost.

1 Triampur compositum

New generation diuretic
Country: Israel
Average price: 320 rub.
Rating (2019): 4.9

Israeli-made tablets are weak decongestants. By removing excess fluid, toxins and salts, they do not flush potassium from the body. That is why they are considered a safe diuretic. It relieves edema syndrome in liver diseases and chronic heart failure. The drug can be taken in complex treatment to achieve maximum effect.

The diuretic effect begins after 15 minutes and lasts 12 hours. According to doctors, the product relieves swelling of the face without harming health. It is quickly absorbed in the gastrointestinal tract. Advantages: mild and effective medicine, potassium-sparing diuretic, safe for severe diseases. No cons were found.

The best diuretics for leg swelling

Leg swelling occurs due to various reasons. These are diseases of the cardiovascular system or the result of use medications. Swelling may occur after drinking too much liquid or salty foods. In any case, you need to help the body remove moisture and relieve unpleasant symptoms. Diuretics improve the functioning of the excretory system and remove excess fluid and salts stagnant in the tissues.

4 Amiloride

An effective remedy for swelling of the legs
Country: Germany
Average price: 250 rub.
Rating (2019): 4.6

"Amiloride" refers to potassium-sparing diuretics. It copes well with the outflow of excess fluid from the body, without removing nutrients. The drug, on the contrary, promotes the accumulation of potassium and magnesium. It is indicated for use in edema caused by diseases of the kidneys, liver and cardiovascular system. The medicine is prescribed for hypertension; it quickly reduces blood pressure.

The tablets begin to act after 2 hours, the effect lasts from 1 to 2 days. They are well absorbed and completely excreted by the kidneys. Advantages: does not wash out potassium and magnesium, long-lasting effect, normalizes blood pressure, little side effects, relieves swelling from the legs well. No deficiencies were found.

3 Diacarb

Wide spectrum of action
Country: Poland
Average price: 240 rub.
Rating (2019): 4.7

"Diacarb" is a weak diarrhetic, which is recommended for edema associated with diseases of various origins. The main substance is acetazolamide. Additional components in the composition: starch, talc, sodium gluconate. After using the drug, the level of fluid in the body decreases, arterial and intraocular pressure. The diuretic effect is achieved by reducing the amount of electrolytes. It is also indicated for patients as an antiepileptic drug.

According to reviews, the drug effectively relieves swelling of the legs, removes excess fluid, and its effect lasts up to 12 hours. It is well absorbed from the gastrointestinal tract and excreted unchanged by the kidneys. Advantages: mild diuretic, long-lasting effect. Minus: there are side effects.

2 Spironolactone

The most gentle elimination of edema
Country Russia
Average price: 60 rub.
Rating (2019): 4.8

The Russian-made drug belongs to the group of magnesium- and potassium-sparing diuretics. It effectively eliminates swelling of the legs in chronic heart failure. The product removes excess fluid from the body without disturbing the acid-base balance. It is a weak diuretic, so the diuretic effect appears 2-5 days after use.

The tablets are well absorbed from the gastrointestinal tract, almost completely absorbed and excreted by the kidneys. According to patient reviews, the drug rarely causes side effects. Advantages: does not wash magnesium and potassium out of the body, promotes the outflow of moisture, relieves swelling, reduces the load on the heart, is allowed for pregnant women in the second and third trimester. Disadvantages: the effect does not come quickly.

1 Hypothiazide

The best diuretic for hypertension
Country: France
Average price: 100 rub.
Rating (2019): 4.9

The French drug belongs to the group of intermediate-acting thiazide diuretics. It is indicated for use in cases of edema due to chronic cardiac and renal failure. Hypothiazide is a prophylactic agent that prevents the formation of stones in the genitourinary system.

The therapeutic effect occurs within 2 hours and persists for 10-12 hours. It can be used as an independent remedy or in complex treatment. According to doctors, the drug has long proven itself with positive side: it does an excellent job of removing excess fluid and lowers blood pressure. The advantages are considered effective reduction swelling of the legs, long-lasting action, low price. No cons found.

The best diuretics during pregnancy

Swelling during pregnancy appears mainly in the second and third trimester, although some women begin to worry about it already in the first months. It all depends on the individual characteristics of the organism. To eliminate unpleasant symptoms, diuretics are used, which remove excess fluid while preventing the leaching of beneficial substances. Before starting treatment, you must consult your doctor. We present diuretics for pregnant women that are effective and safe for the health of the mother and the unborn baby.

3 Eufillin

Low price
Country Russia
Average price: 20 rub.
Rating (2019): 4.6

"Eufillin" is one of the best medications, which copes with swelling during pregnancy. It promotes vasodilation, helps the kidneys better remove excess fluid from the body, and normalizes high blood pressure. In addition, it is indicated for the treatment of placental insufficiency, with chronic diseases lungs and bronchial asthma. The drug should be taken under the strict supervision of a doctor. It is prescribed in short courses for severe swelling.

According to reviews, the medicine effectively removes excess fluid from the body, is a good antispasmodic, reduces swelling and discomfort. After administration, it is quickly and completely absorbed. Pros: copes well with swelling, low price. Disadvantages: there are contraindications.

2 Phytolysin

The safest remedy
Country: Poland
Average price: 350 rub.
Rating (2019): 4.8

The tablets are a diuretic of plant origin. The active natural substances included in the composition: extracts of horsetail, goldenrod, wheatgrass, parsley, birch leaves - have an antispasmodic effect. Orange, sage, pine and peppermint oils have an anti-inflammatory effect. The drug helps remove excess fluid, as well as stones from Bladder and kidneys. It is an effective prophylactic agent that prevents their formation.

"Fitolysin" is used alone or as part of complex therapy for inflammation of the urinary tract and urolithiasis. It is suitable for treating newborns and women at any stage of pregnancy. Advantages: natural composition, no contraindications, effective action. No cons were found.

1 Canephron

The best herbal preparation for pregnant women
Country: Germany
Average price: 430 rub.
Rating (2019): 4.9

Safe remedy natural origin has not only diuretic, but also antispasmodic, anti-inflammatory and antiseptic effect. Includes: herbal ingredients: rosemary, centaury, rose hips, lovage. The medicine is indicated for infectious and inflammatory processes in the kidneys. It is prescribed as a prophylactic for urolithiasis. During pregnancy is the best safe drug to remove excess fluid from the body and get rid of swelling.

According to reviews from expectant mothers, Canephron is a mild diuretic that does not cause side effects. Pros: can be taken at any stage of pregnancy, no contraindications, herbal composition. No deficiencies found.

Solutions) have become quite firmly established in our lives. They are used to correct acid-base balance in organism. After all, they perfectly remove excess acid and alkali from it. Diuretic tablets, the list of which is quite impressive, are used in the treatment of poisoning, some injuries (especially when it comes to head injuries), and to combat hypertension. But, unfortunately, not everyone knows not only the mechanism of action of these drugs, but also the side effects that they can cause. And improper use of diuretics can lead to serious complications.

brief information

Diuretic tablets are used to treat many ailments. The list of effective drugs continues to grow today. Diuretics are also called diuretics.

Their main goal is to remove excess water, chemicals, and salts from the body, which tend to accumulate in the walls of blood vessels and tissues. In addition, diuretics have positive influence on water-salt balance.

If a large number of sodium ions accumulate in the body, it begins to be deposited. subcutaneous tissue. It has a very negative effect on the functioning of the kidneys, heart, and hematopoietic system. As a result, the patient develops a variety of diseases and disorders.

In addition, diuretics are in great demand in sports medicine. They are often used for weight loss. Very often, diuretics (tablets) are included in complex therapy to combat various ailments.

Based on their effect on the body, modern diuretics are divided into two main forms. The first category of drugs affects the process of urine formation directly in the kidneys. The second form of diuretics is responsible for the hormonal regulation of urine production.

Important Warning

There is a lot of information that diuretic tablets, the list of which is given below, can also easily solve cosmetic problems. However, many people believe that similar drugs completely safe. Some women take these medications on their own for weight loss purposes. Athletes widely use drugs before competitions in order to lose weight. Even bodybuilders use them, trying to create artificial dehydration so that the muscles look more prominent.

However, people who take diuretics without a doctor's prescription are at great risk. After all, treatment with diuretics can lead to unpleasant consequences. You should know that diuretics can:

Quite often, even those patients who understand the risk believe that the latest drugs"Indapamide", "Torasemide", "Arifon" do not affect metabolism harmful influence. Such medications are indeed much better tolerated than older generation medications. However, they are also harmful to health. But negative impact these funds are revealed much later. It is enough to understand the mechanism of their action. Medicines of the new and old generation are aimed at one thing - to stimulate the kidneys to work more intensively. Consequently, they excrete more salt and water.

It is important to understand that fluid retention in the body is a symptom of a serious illness. Swelling cannot occur on its own. It is provoked by serious disruptions in the functioning of the kidneys, heart, and sometimes other reasons. Consequently, diuretics are drugs (their list is very extensive) with exclusively symptomatic action. Unfortunately, they do not get rid of the cause of the disease. Thus, medications only delay the unpleasant ending for patients. Therefore, people who want to improve their health and fight real disease, should not make do with diuretics alone, much less use them independently.

Classification of drugs

Until today, there is no single system according to which all diuretics are divided, since all drugs have different chemical structure, have different effects on body systems. Therefore, it is impossible to create an ideal classification.

Often the division occurs according to the mechanism of action. According to this classification, there are:

1. Thiazide drugs. They are excellent for the treatment of hypertension, perfectly reduce blood pressure. It is recommended to use them in parallel with other medications. Thiazides can negatively affect metabolism, so such diuretics are prescribed in small quantities. Drugs (a list of only the most popular ones is given in the article) from this group are “Ezidrex”, “Hydrochlorothiazide”, “Chlorthalidone”, “Indapamide”, “Hypothiazide”, “Arifon”.
2. Loop means. They remove salt and fluid from the body due to their effect on kidney filtration. These medications have a rapid diuretic effect. Loop diuretics do not affect cholesterol levels and do not create preconditions for the occurrence of diabetes mellitus. However, their biggest drawback is the many side effects. The most common drugs are Torasemide, Furosemide, Ethacrynic acid, Bumetanide.
3. Potassium-sparing agents. Quite an extensive group of drugs. Such medications help increase the excretion of chloride and sodium from the body. At the same time, the removal of potassium is minimized by such diuretic tablets. List of the most popular drugs: Amiloride, Triamterene, Spironolactone.
4. Aldosterone antagonists. These diuretics block the natural hormone that retains salt and moisture in the body. Drugs that neutralize aldosterone promote fluid removal. At the same time, the potassium content in the body does not decrease. The most popular representative is “Veroshpiron”.

Medicines for edema

For good effect may be applied potent drugs. The following diuretic tablets are used for edema:

• "Torasemide";
• "Furosemide";
• "Piretanide";
• "Xipamide";
• "Bumetanide".

Medium-strength diuretic tablets can also be used for edema:

• "Hydrochlorothiazide";
• "Hypothiazide";
• "Chlorthalidone";
• "Klopamide";
• "Polythiazide";
• "Indapamide";
• "Met hall."

Such drugs are used for a long time and continuously. The recommended dose is determined by the attending physician. As a rule, it is about 25 mg per day.

For minor edema, potassium-sparing diuretics, such as Spironolactone, Amiloride, and Triamterene, are more suitable. They are taken in courses (2-3 weeks) at intervals of 10-14 days.

Medicines for hypertension

Diuretic medications that are used for high blood pressure, are divided into two categories:

1. Remedies that have a quick effect. Such drugs are used during a hypertensive crisis, when there is a need to quickly reduce blood pressure.
2. Products for daily use. Medicines help maintain optimal blood pressure levels.

Potent medications can stop a hypertensive crisis. The most popular drug is Furosemide. Its price is low. The following remedies are no less effective during a crisis:

• "Torasemide";
• "Bumetanide";
• "Ethacrynic acid";
• "Piretanide";
• "Xipamide."

The duration of taking the above medications can be 1-3 days. After stopping the crisis, they switch from such potent drugs to medications that can maintain blood pressure at the required level every day.

• "Indapamide";
• "Hydrochlorothiazide";
• "Hypothiazide";
• "Klopamide";
• "Metro salon";
• "Polythiazide";
• "Chlorthalidone."

These medications are taken daily as prescribed by your doctor. They perfectly maintain the optimal pressure level.

Drugs for heart failure

As a result of this pathology, fluid retention in the body often occurs. This phenomenon creates stagnation of blood in the lungs. The patient exhibits many unpleasant symptoms, such as shortness of breath, swelling, enlarged liver, and wheezing in the heart.

For people with diabetes, the doctor must introduce a diuretic into their therapy. It perfectly prevents the most severe consequences in the lungs, cardiogenic shock. At the same time, diuretics increase patients' tolerance to physical activity.

For patients with the first and second degrees of the disease, a good diuretic is a thiazide drug. In case of more serious pathology, the patient is transferred to strong remedy- loop diuretic. In some cases, the drug Spironolactone is additionally prescribed. It is especially important to take such a remedy if the patient has developed hypokalemia.

If the effect of using the drug Furosemide weakens, cardiologists recommend replacing it with the drug Torasemide. It has been noticed that the latter remedy has a more beneficial effect on the body when severe forms heart failure.

The drug "Furosemide"

The medicine is a fast-acting diuretic. Its effect occurs after taking it for 20 minutes. The duration of the drug's effect is about 4-5 hours.

Effectively this remedy not only to relieve a hypertensive crisis. According to the instructions, the medicine helps with heart failure, swelling of the brain and lungs, poisoning chemicals. It is often prescribed for late toxicosis during pregnancy.

However, the product also has strict contraindications. The drug is not used in the first trimester of pregnancy. It should not be used by patients with renal failure, people who have hypoglycemia, or urinary tract obstruction.

The cost of the drug "Furosemide" is low. The price is approximately 19 rubles.

The drug "Torasemide"

The medicine is fast-acting remedy. The drug "Furosemide" undergoes biotransformation in the kidneys, so it is not suitable for all patients. More effective medicine For people suffering from kidney diseases, the medicine “Torasemide” is used, since it undergoes biotransformation in the liver. But with pathologies of this organ, the medicine can cause serious harm.

After just 15 minutes, the effect on the body begins (as reported by the product included with the drug, the price of the product varies from 205 to 655 rubles.

Long-term studies have confirmed high efficiency medications for heart failure. In addition, the drug perfectly removes salts and liquid. At the same time, the loss of potassium by the body is insignificant, since effective remedy blocks the hormone aldosterone.

The drug "Indapamide"

The medicine is very effective for hypertension (severe and moderate). The product perfectly reduces blood pressure and maintains its optimal level throughout the day. In addition, it prevents an increase in this indicator in the morning.

You need to take the medicine once a day, 1 tablet, as evidenced by the instructions included in the drug “Indapamide”. The price of the product varies on average from 22 to 110 rubles.

Before taking it, you should familiarize yourself with the contraindications, since this excellent remedy is not suitable for all patients suffering from hypertension. The drug is not intended for people who have problems with the kidneys or liver. Pregnant and nursing mothers are prohibited from taking the medicine. In case of failures cerebral circulation, anuria, hypokalemia, the drug is contraindicated.

The drug "Triamterene"

The medicine is a mild diuretic. It is recommended to use it in combination with another diuretic drug, Hydrochlorothiazide. Thanks to this combination, it is possible to reduce the loss of potassium by the body. The drug Triamterene has a beneficial effect. The instructions position it as a potassium-sparing agent.

The medicine should be used strictly according to the prescribed dosage. People with impaired kidney function may experience an unpleasant side effect - increased level potassium Sometimes the product can lead to dehydration. When interacting with folic acid The medicine helps increase red blood cells.

The cost of the product is 316 rubles.

The drug "Spironolactone"

The medicine is a potassium- and magnesium-sparing agent. At the same time, it effectively removes sodium and chlorine from the body. After starting to take the drug, the diuretic effect occurs approximately 2-5 days.

Medicine can be prescribed for hypertension, chronic form heart failure, liver cirrhosis. The use of Spironolactone is effective for swelling in the 2nd and 3rd trimester of pregnancy.

The drug is not intended for people diagnosed with diabetes mellitus, renal or liver failure, anuria. It is forbidden to use the product in the first trimester of pregnancy. In case of hyponatremia, hyperkalemia, hypercalcemia, the drug is contraindicated. It should not be administered to people with Addison's disease.

Side effects may also occur when taking the medicine. In some cases, the drug provokes urticaria, itching, drowsiness, headache, diarrhea or constipation.

The cost of the product is about 54 rubles.

Diuretic effect this drug helps reduce blood pressure. It begins to appear 2-5 days after starting to take Veroshpiron, and persists for 3 days after its discontinuation. After oral administration, spironolactone is completely absorbed from digestive tract into the blood and enters the kidneys, providing a diuretic effect. The drug is excreted from the body mainly through urine and partly through feces.

Release forms

• White (or almost white) tablets with a bevel, flat, round, on one side there is the marking “VEROSPIRON” - 25 mg each, 20 pieces in one blister, in a cardboard package.
• Capsules with cap yellow color and white body, hard, gelatinous, with a granular fine-grained mixture white– 50 mg each, 10 pieces in a blister, 3 blisters in a cardboard package.
• Capsules with cap orange color and yellow body, gelatin, hard, with a granular fine-grained mixture of white color - 100 mg each, 10 pieces in a blister, 3 blisters in a cardboard package.

It is recommended to take Veroshpiron simultaneously with meals or immediately after them. If you miss a dosage, if no more than 4 hours have passed since the prescribed time, you must immediately take the missed dose of the drug. In other cases, you should take the medicine in the usual dosage during your next appointment.

While taking Veroshpiron, it is recommended to avoid consuming excessive amounts of salt and foods rich in potassium (apricots, tomatoes, peaches, dates, oranges, coconuts, grapefruits, bananas, prunes). During treatment with this drug, the consumption of alcoholic beverages is prohibited.

In the initial period of taking Veroshpiron, it is necessary to abandon activities that require the speed of psychomotor reactions and increased attention(control vehicles, work with complex mechanisms etc.). The duration of such restrictions depends on individual characteristics the patient's health status.

When prescribing Veroshpiron to elderly people, patients with severe kidney and liver diseases, constant laboratory monitoring of kidney function and the level of electrolytes in the blood serum is recommended. The same monitoring is necessary for patients who are receiving non-steroidal anti-inflammatory drugs while taking this diuretic. If necessary, the doctor can adjust the dose of the drug.

Dosage
The dosage and duration of taking Veroshpiron is determined only by a doctor, and depends on the diagnosis and severity of the condition:

• Essential hypertension - 50-100 mg once a day, then the dose can be gradually increased to 200 mg (once every 2 weeks), duration of administration is at least 2 weeks.
• Idiopathic hyperaldosteronism – 100-400 mg once a day.
• Severe hyperaldosteronism and hypokalemia – 300-400 mg 2-3 times a day; then, as the condition improves, the dose can be reduced to 25 mg per day.
• Edema in nephrotic syndrome – 100-200 mg per day.
• Edema in heart failure - 100-200 mg 2-3 times a day, for 5 days in combination with thiazide diuretics; then the maintenance dosage can be reduced to 25 mg (determined individually).
• Edema in liver cirrhosis - the dose of Veroshpiron depends on the ratio of Na+/K+ ions in the urine. If this ratio is greater than 1.0, 100 mg is prescribed once a day; if the ratio is less than 1.0, 200-400 mg is recommended once a day; then the maintenance dose is determined individually.
• Diagnostic test for hyperaldosteronism - 400 mg per day, divided into several doses, taken for 4 days. For a long-term test, it may be recommended to take 400 mg per day for 3-4 weeks.
• Preoperative preparation for primary hyperaldosteronism - 100-400 mg per day, divided into 2-3 doses; The duration of treatment is determined individually.

Overdose

• nausea and vomiting;
• diarrhea;
• skin rash;
• confusion;
• drowsiness;
• dehydration of the body.

Veroshpiron for children

Despite the fact that contraindications for this drug indicate a restriction for use by children under 3 years of age, in practice the drug is in some cases prescribed to younger children (including infants). However, treatment with Veroshpiron for children of this age group carried out in a hospital setting or under strict medical supervision.

Dosage of Veroshpiron for edema in children:
1. Initial daily dose– 1-3 mg/kg for 1-4 doses.
2. After 5 days, the initial dose can be adjusted (if necessary, it can be increased 3 times).

Children under 6 years of age are recommended to take tablets of this drug. For children who cannot swallow the tablet on their own, grind it into powder and mix it with milk or baby food.

In some cases, especially in infants, vomiting occurs after taking Veroshpiron. If it appears earlier than half an hour after administration, the child must be given another dose of the drug. If more than half an hour has passed from the time of administration to the attack of vomiting, then there is no need to give another dose.

An overdose of Veroshpiron in children is especially dangerous. younger age. It is accompanied by an increase in many side effects. The child becomes increasingly drowsy, weak, and may experience heart rhythm disturbances or convulsions. Signs of dehydration are also detected: lack of saliva, the skin becomes dry, and there may be vomiting or diarrhea. In such cases, it is necessary to urgently stop taking the drug, rinse the child’s stomach and call a doctor or an ambulance.

Use during pregnancy and lactation

If it is necessary to prescribe this drug to nursing mothers, it is recommended to stop breastfeeding, since spironolactone can pass into milk and have a negative effect on the child’s body.

Veroshpiron for weight loss

This diuretic helps remove sodium and calcium ions from the body and causes dehydration. Loss of electrolytes can lead to seizures and cardiac dysfunction, while dehydration can lead to disruption of all body functions. These problems can bring those who want to lose weight this way to the intensive care unit and cause serious health problems in the future.

Also, taking Veroshpiron for the purpose of losing weight may be accompanied by a number of side effects of this drug:

• tendency to bleed;
• liver dysfunction;
• diarrhea, vomiting and nausea;
• violations menstrual cycle in women or gynecomastia in men;
• stomach diseases, etc.

Remember! Taking Veroshpiron and other diuretics for the purpose of losing weight is absolutely unjustified and dangerous!

Drug interactions of Veroshpiron

In addition, Indapamide is effective in lowering blood pressure in people with one kidney or on hemodialysis.

The high safety and good tolerability of Indapamide allow it to be considered the drug of choice for the treatment of hypertension in people suffering from diabetes mellitus, chronic renal failure or hyperlipidemia ( increased content cholesterol, triglycerides, low-density lipoproteins in the blood).

Indications for use

• Arterial hypertension ;
• Elimination of edema syndrome in chronic heart failure (this indication is not registered in all countries).

Instructions for use

How to take Indapamide capsules and tablets

Thus, tablets and capsules must be taken orally, swallowed whole, without biting, chewing or crushing in any other way, but with a sufficient amount of still water (at least half a glass). Tablets and capsules can be taken regardless of meals, that is, at any convenient time.

It is optimal to take tablets or capsules in the morning, at approximately the same time every day, to ensure that a certain concentration of the drug in the blood is constantly maintained.

For arterial hypertension, Indapamide should be taken 2.5 mg (1 tablet or capsule) once a day for at least three months. In general, therapy is long-term and can last for months or years. However, it must be remembered that if after 4 to 8 weeks of taking Indapamide, blood pressure does not normalize, then you should additionally start taking some other antihypertensive drug that is not a diuretic (for example, beta-blockers, ACE inhibitors, etc.).

Increasing the dosage of Indapamide to more than 2.5 mg per day is not recommended, since this will not lead to a significant increase in the hypotensive effect, but will cause a diuretic effect.

Maximum permissible daily dosage Indapamide is currently considered 5 mg (2 tablets or capsules).

Indapamide can be used either alone or in combination with other antihypertensive drugs (beta-blockers, ACE inhibitors). When using the drug as part of complex therapy, its dosage, as a rule, is not reduced, leaving it at 2.5 mg per day. When combining Indapamide with beta-blockers (for example, Metoprolol, Bisoprolol, Atenolol, Timolol, etc.), both drugs can be taken simultaneously. If Indapamide must be combined with ACE inhibitors (for example, Captopril, Enalapril, Perindopril, etc.), then in this case it is necessary to proceed as follows: 3 - 4 days before the start of administration ACE inhibitor cancel Indapamide; then, after gaining a maintenance dosage of the ACE inhibitor, Indapamide is resumed and both drugs are taken.
pressure (if it was elevated; normal blood pressure does not decrease). The drug also helps remove potassium, bicarbonate and magnesium ions from the body, but to a lesser extent.

The diuretic (diuretic) effect begins 1-2 hours after taking the drug, reaches a maximum after 4 hours and lasts 6-12 hours. Long-term use Hypothiazide does not reduce its diuretic effect. Limiting the consumption of table salt with food increases hypotensive effect drug.

Intraocular pressure is also reduced by Hypothiazide. The drug can cross the placental barrier. Excreted from the body in urine and breast milk. In case of renal failure, the release of the drug slows down significantly.

The active substance of the drug is hydrochlorothiazide.

Release forms

By far the most common disease is hypertension or hypertension. In other words, this is high blood pressure. This disease develops due to external factors eg stress, overwork, physical exercise, insufficient rest, abrupt change weather or illness internal organs. Unfortunately, this pathology cannot be completely cured - it is a chronic disease.

At the first signs of hypertension, you should immediately consult a doctor. The specialist will select an individual complex treatment, which will help keep blood pressure normal and eliminate severe symptoms. Any therapy includes diuretics. These drugs have different chemical composition, however, they all effectively remove excess fluid from the body. Medicines are diuretics. Often, the doctor includes the drug Indapamide in the main therapy, instructions for use of which and at what pressure the medicine should be taken will be discussed in this article.

General characteristics of the drug

Indapamide is a well-known diuretic that is actively used in the treatment of hypertension, as well as swelling caused by heart failure. The tablets effectively remove excess fluid from the body and qualitatively dilate blood vessels, which helps normalize blood pressure.

The drug is produced in the form of tablets, which are coated on top with a white coating. One package can contain 10 or 30 tablets, which allows a person to choose the required amount for himself.

The drug is produced by many pharmacological companies, but their composition does not change. Basics active substance- This is indapamide. One tablet contains about 2.5 mg. In addition to this substance, the drug contains additional components that have a positive effect on the body. The medicinal product contains the following auxiliary ingredients:

• potato starch;
• Kollidon CL;
• milk sugar or lactose;
• magnesium stearate;
• povidone 30;
• talc;
• cellulose.

Important! What kind of blood pressure does Indapamide help with? The drug is prescribed for increased rate HELL. Its active components are able to quickly remove excess fluid from the body, and also qualitatively dilate blood vessels. Thanks to this effect, the drug effectively normalizes blood pressure.

Mechanism of action on the body

The drug has an active effect on the body. Its components quickly remove fluid and accumulated salts from the body. They encourage rapid education urine, which helps remove fluid from tissues and serous cavities.

pharmachologic effect

Indapamide is a high-quality diuretic that belongs to the thiazide-like diuretics. Additionally, the drug dilates blood vessels and tones their walls. Taken together, such interactions help normalize blood pressure and improve a person’s general condition.

If the daily dose is 1.5–2.5 mg, then this is enough to prevent vasoconstriction. This means that the pressure will be within normal limits. In addition, this dosage helps improve the walls blood vessels and protects the heart muscle from changes in blood pressure. If the dosage of the drug is increased to 5 mg per day, then this amount will be enough to relieve swelling. However, the increased dose has no effect on blood pressure levels.

When taken regularly, a noticeable effect is achieved after 7–14 days of taking the drug. The drug has its maximum effect after 2–3 months of therapy. The positive effect lasts for 8 weeks. If the tablet is taken once, the desired result occurs within 12–24 hours.

It is better to take the medicine on an empty stomach or after a meal, since taking the tablet with food slows down its effect on the body, but does not affect its effectiveness. The active components of Indapamide are quickly absorbed into gastrointestinal tract, so they are distributed evenly throughout the body.

The liver effectively cleanses the body of the chemical components of the pills. They are also processed by the kidneys and excreted in urine (70–80%) after about 16 hours. Excretion through the digestive organs is about 20–30%. Basic active ingredient V pure form is excreted by approximately 5%. All its other parts have the necessary effect on the body.

Indications for use

Indapamide is effective drug, which is widely used in medicine to restore blood pressure. As a rule, doctors recommend it for the following diseases of the body:

• hypertension 1 and 2 degrees;
• edema caused by heart failure.

How to use

Indapamide is recommended to be taken as a tablet (2.5 mg) once a day. It must be swallowed whole, without chewing, and washed down with plenty of water. However, if therapy does not produce the required results after 1–2 months, then the established dosage should not be increased, as the risk of side effects increases. In this situation, the doctor may recommend changing the drug or supplementing it with another medicine.