Dimexide taken orally: consequences. What to do and how to treat a chemical burn from dimexide in a hospital and at home. Carpal tunnel syndrome

Dimexide is a drug for topical use. It is used for treatment various diseases joints, skin, ligaments and bones. It has antimicrobial, antiseptic and analgesic effects. Dimexide poisoning can develop due to improper or prolonged use. In this article, we looked at the symptoms that manifest this condition, first aid and treatment.

Description of the drug

Dimexide is available in the form aqueous solution, sold in 50 or 100 ml bottles. This drug is sold without a medical prescription.

This the medicinal product is intended for topical use only. Drinking and swallowing it is strictly prohibited.

When applied to the skin, the medicine acts not only locally, but also, when absorbed, enters the bloodstream. Before starting treatment with this drug, you should consult your doctor.

Effect of the drug

Dimexide has a complex effect on the pathological focus. When applied to a problem area of ​​the body, it has the following effects:

• relieves pain. This drug used as a local anesthetic;
• reduces the severity of the inflammatory reaction;
• destroys pathogenic microorganisms that cause the inflammatory reaction;
• makes resistant bacteria sensitive to antibacterial therapy.

Dimexide is quickly absorbed and can act not only on the surface of the skin, but also in joints, bones, tendons and ligaments. Compresses with antibiotics, steroids and anti-inflammatory drugs are often made based on this medicine.

Doctors call dimexide a “conductor.” If it is necessary to facilitate the penetration of a drug into the subcutaneous layers, it is used together with dimexide.

Indications

Dimexide is widely used in modern medicine for the treatment of the following diseases:

• rheumatoid arthritis;
• Bekhterev's disease;
• sprain of the ligaments of the joints;
• arthrosis and arthritis of various etiologies;
• traumatic infiltrates;
• bruises;
• abscesses and phlegmons;
• purulent wounds;
• boils and carbuncles;
• osteomyelitis;
• trophic ulcers.

Contraindications

Dimexide, absorbed into the blood, affects the entire body. It should absolutely not be used for:

• acute or chronic renal failure;
• allergic intolerance to the drug or its components;
• coronary heart disease in the form of angina pectoris, myocardial ischemia;
• increased intraocular pressure, glaucoma, cataracts;
• impaired consciousness of the patient, comatose state;
• pregnancy and lactation;
• children under 12 years of age.

Drug poisoning

Dimexide poisoning can develop as a result of its improper use or long-term treatment with it. Also at risk are people who decide to self-medicate.

With topical use of dimexide, overdose occurs extremely rarely. She may occur if a person ingests the drug orally.

A child can be poisoned by medicine by accidentally drinking a bottle. Children love to taste everything, so all medications without exception should be stored in places inaccessible to them.

In case of an overdose of the drug, an acute allergic reaction may develop. Most often it occurs in the form of urticaria. The patient develops red, streakless rashes. This rash is characterized by severe itching.

In rare cases, a more pronounced allergic reaction develops - in the form of angioedema. At the same time, the patient’s face begins to swell, especially the eyelids and lips. Swelling can also develop in the oropharynx, leading to asphyxia and suffocation. The patient begins to cough and feel short of air.

What to do if you develop an allergy to a drug

If an acute allergic reaction develops you need to call an ambulance immediately. Describe the patient’s condition to the dispatcher and give the correct address. While waiting for doctors, you need to begin to provide first aid to the victim yourself. Below are its main components:

1. Thoroughly rinse any remaining product from the skin.
2. Open the windows in the room in which the patient is located, and make sure that no items of clothing interfere with his breathing.
3. If you have antihistamines (anti-allergic) drugs in your home medicine cabinet, give them to the patient to drink. In this case, you must strictly follow the dosage rules specified in the instructions.
4. If poisoning has developed as a result of taking the drug orally, you need to give the poisoned person to drink several glasses of water and then induce vomiting. Then the patient needs to take a sorbent, for example, activated carbon, or enterosgel.

The ambulance team, upon arriving at the call, will examine the patient and determine the severity of his condition. For angioedema, the following drugs are administered intravenously:

• antihistamines, for example, diphenhydramine or suprastin.
• corticosteroids - dexamethasone or prednisolone.

If the patient’s condition does not improve after the medications are administered, he is taken to the nearest on-duty hospital to the therapy department.

Side effects of dimexide

The drug dimexide may cause the development side effects. They may occur even if correct use medicine. Side effects of dimexide include the following conditions:

• dizziness;
• itching and redness of the skin;
• sleep disturbance, insomnia;
• diarrhea;
• general lethargy, fatigue, weakness;
• bronchospasm;
• nausea and vomiting;
• abdominal pain.

If the above symptoms appear, you should immediately stop using the drug. Then you need to wash it off the skin and contact your doctor.

Most of these symptoms disappear after stopping the drug. Your doctor will prescribe you a different medicine.

Dimexide is widely used to treat inflammatory diseases of the joints and skin. Before you start using it, you should definitely consult your doctor.. In case of an overdose of this medicine, allergies may develop in the form of urticaria or angioedema. If an acute allergic reaction develops, you should call an ambulance and take an antihistamine.

Dimethyl sulfoxide (DMSO) is a chemical substance with the formula - (CH3)2SO. Colorless liquid, an important bipolar aprotic solvent. It has found wide application in various fields of chemistry, as well as as a medicine.

History of the study

It was first synthesized in 1866 by Russian chemist Alexander Zaitsev by oxidizing dimethyl sulfide with nitric acid. Over the next few decades, studies of the properties of this compound were not systematic. Interest in dimethyl sulfoxide increased greatly after its unique solvent properties were discovered in 1958. In 1960, industrial production of dimethyl sulfoxide began. After this, the number of publications devoted to the study of the properties of DMSO increased sharply.

Receipt

The main method for producing DMSO is the oxidation of dimethyl sulfide. In industry, this process is carried out using nitric acid. DMSO is a by-product of the pulp and paper industry. Annual production of DMSO is measured in tens of thousands of tons.

In laboratory conditions, potassium periodate can be used in an organic solvent-water system for the mild and selective oxidation of dimethyl sulfide. However laboratory methods obtaining DMSO has no practical significance. This is due to the inconvenience of working with dimethyl sulfide, as well as the low commercial cost of the finished solvent.

Physical and chemical properties

DMSO is a viscous, colorless liquid, almost odorless. When mixed with water it becomes very hot. Reacts with methyl iodide to form sulfoxonium ion, which is capable of reacting with sodium hydride.

Application

Use as a solvent

DMSO is an important bipolar aprotic solvent. It is less toxic than other members of this group, such as dimethylformamide, dimethylacetamide, N-methyl-2-pyrrolidone, HMPTA. Due to its strong solvent power, DMSO is often used as a solvent in chemical reactions involving inorganic salts, in particular in nucleophilic substitution reactions. The acidic properties of DMSO are weak, so it has become an important solvent in the chemistry of carbon anions. Nonaqueous pKa values ​​for hundreds of organic compounds have been measured in DMSO.

Due to its high boiling point, DMSO evaporates extremely slowly at normal atmospheric pressure. This makes it a very convenient solvent for reactions when heated. At the same time quite heat melting limits its use at low temperatures. After carrying out the reaction in DMSO solution, reaction mixtures are most often diluted with water to precipitate organic substances.

The deuterated form of DMSO, also known as DMSO-d6, is a convenient solvent for NMR spectroscopy due to its high solubility for a wide range of substances, the simplicity of its own spectrum, and its stability at high temperatures. The disadvantages of DMSO-d6 as a solvent for NMR spectroscopy are its high viscosity, which broadens the signals in the spectrum, and its high boiling point, which makes it difficult to reverse isolate the substance after analysis. Often DMSO-d6 is mixed with CDCl3 or CD2Cl2 to reduce viscosity and melting point.

DMSO finds everything more ways applications in microelectronics production.

DMSO is a more effective and safer paint stain remover than gasoline or dichloromethane.

DMSO is also the only way, removing Super glue and polyurethane foam.

Application in biology

DMSO is used in PCR to inhibit the pairing of parent DNA molecules. It is added to the PCR mixture before the start of the reaction, where it interacts with complementary sections of DNA, preventing them from pairing and reducing the number of side processes.

DMSO is also used as a cryoprotectant. It is added to the cell medium to prevent damage to cells when they are frozen. Approximately 10% DMSO can be used to safely cool cells and also to store them at liquid nitrogen temperatures.

Application in medicine

As a medicine, purified dimethyl sulfoxide is used in the form of aqueous solutions (10-50%), as a local anti-inflammatory and analgesic, and also as part of ointments to increase the transdermal transfer of active substances, since it penetrates the skin in a few seconds and transports other substances. Tradename drug - "Dimexide".

Cleaning

In addition to water impurities, dimethyl sulfoxide may also contain dimethyl sulfide and sulfones. These impurities are removed by incubating DMSO over barium oxide, sodium hydroxide, dryerite, or fresh activated alumina for 12 hours. After this, the substance is distilled under reduced pressure (~2-4 mm Hg, boiling point 50 ° C - that is, 328 K) over granules of caustic soda or barium oxide. Use a 4A molecular sieve to store purified DMSO.

General effect on the body

DMSO and microcirculation

Improves microcirculation in brain tissue and other areas of the body. Improves microcirculation processes in joint tissues. Prevents development DIC syndrome, primarily its local manifestations. The leading role in the development of this phenomenon belongs to the fibrinogen-fibrin system. With rheumatism, hypercoagulation always occurs. DMSO reduces blood clotting time and improves microcirculation in the affected area. Reduces the tendency of red blood cells to aggregate. Normalizes the process of fibrin formation, which improves tissue trophism. Improves the nutritional conditions of the transplanted skin flap by expanding the capillary network and increases the total number of functioning vessels. Creates the most favorable conditions for the healing of skin flaps and preventing the development of necrosis in them.

It has a vasodilating effect and has a moderately expressed hypotensive effect. Reduces resistance peripheral vessels.

Improves the rheological properties of blood, reduces adhesiveness and aggregation of blood cells.

Like histamine, it increases the permeability of the walls of venules. Easily penetrates skin and cell membranes without damaging them. Penetrating through intact skin, it carries various medicinal substances.

Significantly, several times, increases the permeability of the histohematological barriers of the lungs and liver, without however affecting the permeability of the histohematological barriers of the kidneys. Increases the permeability of the blood-brain and blood-ophthalmic barriers. Deposits medicinal substances in tissues for 1-2 weeks. It has a unique ability to conduct (transport) substances dissolved in it through the skin and mucous membranes without damaging them. It disrupts hydrophobic bonds and lipoprotein complexes of cell membranes, which underlies the increase in their permeability under the influence of DMSO. Promotes long-term deposition of drugs in tissues.

Anti-inflammatory effect

Dimexide's anti-inflammatory activity is comparable to non-steroidal anti-inflammatory drugs. It has not only local, but also systemic anti-inflammatory effects.

DMSO has an antiexudative effect, inhibits the activity of proteases and the synthesis of prostaglandins. At the same time, it increases the secretion of cortisol and strengthens the membranes of lysosomes. Reduces cellular infiltration at the site of inflammation.

DMSO has a direct antiproteolytic effect, prevents the development of edema and necrosis, and inhibits platelet aggregation. It has an antipyretic effect and suppresses exudation processes at the site of inflammation. A 33% DMSO solution quickly reduces soft tissue swelling. Stimulates reparative processes in tissues, proliferative processes in the focus of inflammation.

Quickly eliminates inflammation of soft tissues. Accelerates the development of granulation tissue, slowing down the processes of scar formation. Tender scars form. Promotes resorption inflammatory infiltrates, including in the stroma of the lungs and pleura. Resolves rough scars, playing the role of a “chemical orderly” in the area of ​​inflammation, a biochemical cleaner.

DMSO interacts with protein breakdown products, forming intermolecular (hydrogen and hydrophobic) bonds with the functional groups of polypeptides - OH, NH, SH, NH2. Promotes their removal from the source of inflammation. Inhibits fibroblast proliferation, and in combination with corticosteroids completely suppresses it.

Inhibits collagen synthesis. Reliably and long-term reduces the level of prostaglandins PgE b, PgF 2a by suppressing the intensity of synthesis of the latter. Reduces and slows down the development of radiation and drug pneumonitis by 1/3.

The drug does not have an allergenic effect. Does not cause contact sensitization when applied to the skin. On the contrary, it has desensitizing and antiallergic activity. According to various sources, it inhibits anaphylactic reactions by 41-72%.

The antiallergic activity of dimexide (as well as other biological effects) is proportional to the concentration of the drug used. The antiallergic activity is based on the ability to suppress B-lymphocytes and plasma cells, blockade of histaminergic serotonergic receptors, antihistamine effect, the ability to inactivate histamine released from mast cells, depleting the pool of histamine-producing cells.

DMSO is a long-acting anesthetic with a pronounced local analgesic effect. Has a long-lasting analgesic effect. Selectively blocks nerve fibers conducting pain impulses. Can be considered as a symptomatic analgesic for pain syndromes of various origins.

Long blockade nerve endings and trunks is achieved by introducing a mixture of DMSO with an anesthetic, and the final concentration of the solvent should be 30-50%. DMSO-induced nerve conduction block is completely reversible.

Potentiates the effect of antibiotics. The antibiotic molecule is solvated with several DMSO molecules, which increases the penetration of antibiotics into tissues. Using the NMR method, it was found that one molecule of antibiotic (penicillin) is solvated with 7 molecules of DMSO. Antibiotic preparations are also dissolved in a 40-50% DMSO solution. Mixtures of dimescid with penicillin, erythromycin, and tetracycline are used.

Importantly, DMSO inhibits bacterial lactamases. The phenomenon of a selective increase in the concentration of antibiotics in the affected tissue with the combined administration of antibiotics with dimexide and their selective accumulation was discovered. The concentration of the antibiotic in the lesion increases 2.5-3 times; Thus, dimexide enhances the antibacterial effect of antibiotics. We can also say that dimexide deposits antibiotics in the affected tissue.

The introduction of antibiotics together with DMSO intravenously and by application opens up new paths in antibiotic therapy and anti-inflammatory therapy.

DMSO has an anticoagulant effect. After intravenous administration of the drug in the form of a 10-20% solution, the volume of plasma, its viscosity, as well as the viscosity of whole blood, clotting time increases. Blood clotting first accelerates, then slows down, changes generally occur in the direction of hypocoagulation. Bleeding time increases slightly. DMSO inhibits platelet aggregation. Normalizes the process of fibrin formation, which improves tissue trophism. The likelihood of thrombosis interferes. Possessing fibrinolytic activity, it normalizes fibrinolysis.

DMSO has antimutagenic activity both in vitro and in vivo. It has strong antioxidant activity. Dimexide prevents lipid peroxidation, stabilizes cell membranes, including lysosome membranes. It scavenges free radicals, primarily OH, which is believed to be largely responsible for the drug's anti-inflammatory effects. To achieve this effect, its concentration in the blood is sufficient from 0.5 to 10 millimoles per liter. At the same time, dimexide enhances the synthesis of superoxide dismutase (SOD) in cells.

Dimexide has also proven itself as an anti-stressor. Has anti-stress and sedative effects. Eliminates reactions of anxiety and fear.

Being a strong oxidizing agent, dimexide is itself an antiseptic. 0.25-10% DMSO solutions have a bacteriostatic effect, and 25-50% solutions are already bactericidal.

When applied to the skin, it reduces residual skin flora by 95%. Eliminates acquired resistance of microorganisms to antibiotics. Has a bactericidal effect against common pathogenic and conditionally pathogenic bacteria.

The drug at a concentration of 26% inhibits the growth of all microorganisms that saproliferate in the blood of cancer patients. When acting on the body, DMSO blocks glycolytic metabolic pathways. Reduces the accumulation of lactate in the blood, thereby reducing lactic acidosis.

Under the influence of dimexide, the concentration of 17-OX in the blood plasma increases by 2-2.5 times. Total oxygen consumption by tissues is reduced by 25%. The concentration of bilirubin in the blood does not change. Inhibits cholinesterase, dissolves collagen.

Dimexide quickly relieves swelling of brain tissue and improves cerebral blood flow, normalizes cerebral hemodynamics and improves the clinical condition of patients.

DMSO reduces heart rate and increases the voltage of ECG waves. The described effects are clearly dose-dependent. If small doses of the drug increase the activity of the heart, then extremely large doses can have an effect on the heart toxic effect, right up to the stop. Has a hypotensive effect. Reduces arterial pressure. Normalizes the reactivity of the autonomic nervous system.

By inhibiting secretion antidiuretic hormone pituitary gland, the administration of DMSO is accompanied by a diuretic effect. By increasing diuresis by 50%, it acts as an osmotic diuretic. According to some authors, under the influence of the drug, diuresis can increase by an order of magnitude.

DMSO is a mild immunosuppressant. Has an immunosuppressive effect on B-lymphocytes, reduces the level of circulating in the blood immune complexes, at the same time stimulates nonspecific reactivity, increases the body's resistance to adverse effects. Induces interferon synthesis. Does not affect the phagocytic activity of polymorphonuclear leukocytes (PMNL). Overall increases functional state macrophage system. Increases the cytolytic activity of blood serum. It has a resolving effect on the site of inflammation. Inhibits the activity of macrophages at the site of inflammation.

DMSO is completely distributed throughout the cells at a concentration of 10-15 millimoles per liter. It is a cell protector of the intracellular type. Penetrates (penetrates cell membranes). Possesses protective effect on cells (celluloprotective effect). White blood cells preserved in DMSO are suitable for serological studies. Reduces PMN alteration.

Well-known cryoprotector. Stabilizes lysosome membranes and other cell membranes. Passes through intact cell membranes.

In liver microsomes it is oxidized to dimethyl sulfone, which is excreted in urine and feces. Another metabolite, dimethyl sulfide, is excreted through the lungs. It has a characteristic “garlic” smell. Strengthens cell membranes and prevents cytolysis. Reduces the stability threshold tumor cells to normal killers. It has the ability to preserve living tissue. For tissue and cell preservation, 30-40% solutions are used. A 10% solution is optimal for this purpose. According to the authors, DMSO protects tissues from post-infarction changes and prevents recurrent heart attacks.

Clinical Applications of DMSO

Psychiatry

DMSO solutions have a sedative effect and tranquilizing activity. Treatment of psychosis (intramuscular injection of a 50% DMSO solution) has a sedative effect on this category of patients.

Neurology

Treatment of strokes and head injuries spinal cord, due to the ability to normalize central and systemic hemodynamics. It has a pronounced anti-edematous effect on brain tissue. Intravenous administration of 10-40% solutions is used for these purposes. For the treatment of radiculitis and sciatica, compresses of 50% DMSO are used, which are applied for 20-30 minutes from 6 to 12 times.

Treatment of trigeminal neuritis (trigeminitis) is long-term, from 1 to 6 months.

DMSO has antiviral effect. Used to treat herpes zoster as independent drug, and together with antiviral compounds. To treat herpes zoster, mefenamic acid, indomethacin, nimesulide or other NSAIDs are dissolved in a 50% DMSO solution. A 50% solution of the medicinal mixture is applied to pain points.

Ophthalmology

Does not damage the organ of vision. Recommended for treatment chronic blepharitis and conjunctivitis in the form of eye drops of 75-66% concentration. Other authors recommend not using DMSO solution for intraconjunctival use more than high concentration, than 50%, because the latter, without damaging the conjunctiva, often cause a subjective burning sensation.

Otorhinolaryngology

Treatment of acute rhinitis: instilling 2 drops of a 30% DMSO solution into both nostrils for several (two) days reduces the duration of acute rhinitis. At this concentration it does not cause side effects. Highly effective in the treatment of purulent otitis, purulent sinusitis in children by rinsing the cavities with a 30-50% DMSO solution. Used as an independent medicine in the treatment of purulent sinusitis.

Pulmonology

The drug has proven effective in treating patients with chronic inflammatory lung diseases, such as chronic bronchitis and chronic pneumonia.

In the treatment of patients with chronic inflammatory lung diseases good effect received from intravenous administration of 50-100 ml of 10-20% DMSO solution. 20-30% solutions of the drug with the addition of proteolytic enzymes and antibiotics are used to carry out so-called “fillings” in the same category of patients. Solutions of the same concentration were also used for sanitation of the pleural cavity. When introducing DMSO with antibiotics into limited cavities, the treatment mixture is left in the cavity for 1.5-2 hours, squeezing the drainage tube.

Reintroduction of DMSO into pleural cavity leads to obliteration of the latter. Used to treat endobronchitis. Reduces and slows down the development of radiation and drug pneumonitis by 1/3.

Gastroenterology

Dimexide has antiulcer activity, because slows down secretory function stomach, reduces secretion gastric juice. Increases the exocrine function of the liver by 50%, enhances bile secretion.

Rheumatism

DMSO is widely used to treat rheumatoid arthritis. Treatment of gout. Treatment of bursitis, arthritis, tendovaginitis. The drug modifies metabolism connective tissue, in particular collagen. Reduces destructive changes in joints. Has a basic effect on the course of chronic arthritis. Let's use it in cosmetology. Treatment of scars leads to their resorption.

Nephrology

Treatment of amyloidosis. Dissolves amyloid fibrils. Patients over 3-5 years of age are prescribed oral administration of a 3-5% solution of DMSO in water, 30 ml 3 times a day, while taking mint preparations.

The oral route of administration in the form of a 3-5% solution is used to prevent the formation of urinary tract stones. The drug is quickly absorbed through the mucous membrane of the gastrointestinal tract.

Urology

Dimexide has found application in the treatment of interstitial cystitis. The drug is instilled through a catheter into the bladder, 50 ml of a 50% solution for 15 minutes. The frequency of instillations is once every two or four weeks. The effect of a single injection was observed for 2-12 months. During this time, patients were free from symptoms of the disease. It is believed that for the treatment of cystitis, dimexide preparations of high concentration, close to 100%, should be used. According to the observations of other researchers, in the treatment of patients with chronic cystitis, instillation of 10% solutions of the drug into the bladder is effective. A sufficient number of instillations is no more than 20.

Gynecology

DMSO does not have embryotoxic or teratogenic properties. It is used for the treatment of pseudo-erosions, cervicitis (tampons, baths with a 10% solution), acute and chronic diseases of the uterus and appendages.

Surgery

Used as an independent medicine in the treatment of bruises, sprains, hemorrhages, swelling, purulent wounds, chronic osteomyelitis, erysipelas, phlebitis and thrombophlebitis by lubricating DMSO + antibiotics over the entire affected area for 20-30 minutes.

Effective in the form of compresses with a 30% solution for the treatment and prevention of joint contracture, diseases of the transverse striated muscles and connective tissue. The drug is effective in treating trophic ulcers lower extremities. Apply to the ulcerative surface in the form of a bandage consisting of 4-6 layers of gauze, abundantly moistened with a 70% solution of the drug. For the first 3 days, the bandage is changed daily, as the wound is cleansed - every other day. With a complete change, the wound is treated with hydrogen peroxide. At the same time, the drug was not effective in treating skin burns.

To treat purulent cavities, it is recommended to use a 30% DMSO solution, rinsing the cavity with it until a clean washing liquid is obtained. After this procedure, a 30% solution of the drug with an antibiotic is injected into the cavity and left for several hours.

Dimexide is an effective means of preventing and correcting septic complications. Treatment of sepsis is especially effective by intravenous administration of antibiotics dissolved in DMSO.

The drug is highly effective in the treatment of purulent wounds. To wash purulent stains and cavities, use a 4-5% solution of the drug, after which the cavity is drained. Reduces the amount of purulent discharge from wounds. Stimulates the formation and growth of granulations. To treat the wound surface, use a 30 or 50% solution containing antibiotics to which the wound microflora is sensitive. Epithelization occurs after 8 days. Pain and swelling of the wound are reduced. Application of DMSO in the form of dressings to wounds reduces pain and prevents the development of purulent complications. To wash purulent cavities, use a 40% DMSO solution, after which the cavity is drained. DMSO improves tissue trophism by eliminating vascular spasm.

Used in treatment open fractures, osteomyelitis, contractures, tendon sprains, pain due to sprains.

DMSO potentiates the effect of drugs used to treat endarteritis, vascular spasms, for example in Raynaud's disease, and is a conductor of vasoactive substances such as nicotinic acid and angiotrophin.

Clinical Oncology and Medical Radiology

Oncological aspects of the action of DMSO

DMSO potentiates the effect of cytostatic drugs.

Does not affect the growth of transplanted tumors in outbred mice. Inhibits the growth of transplants of some human tumors in nude mice.

The drug itself does not have antitumor activity in either humans or animals, however, it has been identified preventive action in relation to the development of neoplasms of the mammary gland and large intestine in rats. Perhaps this effect of the drug is associated with its ability to cause in DNA cell nucleus the appearance of many single breaks, putting these cells into a state of rest, with anti-inflammatory properties and the ability to enhance the antiproliferative effect of interferons against at least cells of several adenocarcinoma lines, in particular human lung adenocarcinoma. In future wide application DMSO in an oncology clinic will be facilitated by its ability to conduct to the tumor and accumulate antitumor drugs in it.

DMSO with antitumor drugs dissolved in it is also used topically in the form of applications and lubricants in the treatment of patients with melanoma, basal cell carcinoma, Bowen's disease, achieving good results. clinical effect. Dimexide is used as a solvent of 5-fluorouracil in the form of a 30-50% solution for the treatment of vulvar cancer. Application of DMSO with radiosensitizers dissolved in it (5-FU, metronidazole) to external tumors can increase the radiosensitivity of the tumor.

The drug is effective in the treatment of mastopathy by applying a 20-30% solution to the mammary glands. A 10% aqueous solution of DMSO with vitamin E (alpha-tocopherol) is also used.

The anti-inflammatory effect of DMSO may be associated with inhibition of protease activity. A dose of 50 mg/kg inhibits the development of brain cancer in rats. Inhibits the growth of leukoblasts in tissue culture.

At a concentration of 3-5%, dimexide has a differentiating effect on erythroblasts, leading to the appearance of signs of a more mature phenotype. The essence of the differentiating effect is the appearance in the phenotype of the cell of characteristics inherent in the phenotype normal cells and the loss of those characteristic of neoplastically transformed ones.

The differentiating effect of a 1-2% DMSO solution on osteosarcoma cells in tissue culture has been described. The differentiating concentration of the drug in culture is 0.75-7%. The optimal concentration of 3% dimexide also causes differentiation of human cervical cancer cells in culture. Reduces the rate of cell proliferation of this malignant tumor when treated with trans-retinoic acid dissolved in DMSO.

The drug has a differentiating effect on human colon adenocarcinoma cells. Manifestations of the differentiating effect are a decrease in the rate of tumor cell division and, as a result, an increase in the doubling time of the tumor. Thus, the potential of the tumor to grow is reduced.

DMSO suppresses the entry of tumor cells into the S period of the mitotic cycle, delays their development in the G-1 phase, thus creating a G-1/S block. This increases the doubling time of tumor cells, reducing the rate of their proliferation.

Differentiation of leukemia cells is accompanied by changes in the parameters of their membranes, as well as the appearance in the DNA of differentiating tumor cells of a small number of single-strand breaks, which entails a change in the DNA conformation, leads to the folding of its molecule and, ultimately, to a change in the number of genes functioning in the tumor cell.

Causes selective death of embryonic hematopoietic cells.

Application of DMSO inhibits the development of skin cancer induced by chemical carcinogens in hairless mice.

Dimexide reduces the threshold of resistance of tumor cells to normal killer cells. Permanent and long-term use dimexide per os in the form of a 5% aqueous solution significantly increases the tumor doubling time. It is believed that while not having an antitumor effect, the drug has a chemopreventive effect. It prevents the development of breast and colon cancer induced by 1-2-dimethylhydrazide in rats.

Therefore, there is an opinion about the possibility of using the drug as a means of preventing and inhibiting the development of malignant neoplasms.

It is believed that the pronounced slowdown in tumor development under the influence of DMSO is due to an extension of the latent period of tumor growth due to an increase in the doubling time of tumor cells. This problem is urgent and requires careful study.

DMSO increases the tolerance of the skin and mucous membranes to radiation. Increases the resistance of living organisms to radiation by 1.4-3 times. The radioprotective effect of DMSO increases with increasing dose of the drug. The radioprotective properties of the drug are associated with the implementation of several mechanisms of its action. As a free radical scavenger, it has a pronounced radioprotective effect by reacting with sulfhydryl groups of proteins. The radioprotective effects of DMSO after irradiation of animals are also associated with the fact that the latter induces in critical radiosensitive organs an increase in the pool of biological amines - histamine, serotonin, dopamine by 20-60% compared to the initial level while simultaneously neutralizing the toxic effects of peroxide products in these same organs. oxidation of lipids, which are considered as natural radiosensitizers. At the same time, the formation of sulfhydryl groups is induced in target tissues: general, acid-soluble and protein. Thus, a triple radioprotective effect occurs.

An increase in the resistance of lysosome membranes under the influence of DMSO delays the development of secondary (mediated) effects of radiation that occur several hours after the effect of the latter on the body.

Another mechanism of the radioprotective effect of demixide is considered as a consequence of its influence on metabolic processes in tissues, namely the ability to reduce oxygen consumption by tissues by approximately 25%, with tissue hypoxia developing in connection with this and a decrease in the production and content of ATP in cells.

The drug preserves stromal cells of the hematopoietic organs, which is a prerequisite for the rapid proliferation of stem cells remaining after irradiation. With total irradiation at a dose of 9 Gy, 38% of irradiated rats receiving DMSO survived, while all animals in the control group died.

DMSO reduces the mutagenic effects of both radiation and chemical mutagens.

In connection with the above, the drug has found a place for the prevention of radiation damage to the skin during radiation therapy to reduce the severity of radiation alopecia. A 90% solution of the drug is applied to the skin, which prevents the appearance and softens the development of radiation-induced epidermites and epitheliitis. The use of dimexide is indicated for the treatment of post-radiation indurates and radiation ulcers, and ulcers of this origin are cured in a period of 2 to 8 weeks. Dimexide is the most important treatment for post-radiation fibrosis. For this purpose, applications of a 30-90% solution of the drug to the affected area are used, if necessary, even for 3 months. Compresses covering areas of healthy tissue are applied for 12-24 hours. Repeat from 6 to 20 times. It is advisable to apply a 50% solution in a volume of 30 ml, distributed over an area of ​​250-500 sq.cm. After applying the bandage, a burning and warm feeling appears.

Dermatology

DMSO is used to treat eczema, streptoderma, fungal diseases of the skin, nails, and pyoderma. The use of a solution of iodine in DMSO for this purpose is especially indicated. Used to treat pustular skin diseases.

Methods of using the drug

Dimexide is not, as follows from the above, a drug for external use only.

A 10% solution is administered intravenously at a rate of 0.5-0.8 and even 1 g/kg. Intravenous administration should be carried out slowly in the form of a 10% solution per isotonic solution sodium chloride. DMSO can be administered intravenously and in the form of a 20-30% solution prepared in an isotonic sodium chloride solution.

The drug is administered intravenously either alone or in combination with other medicines.

An analysis of the experience of more than 5,000 intravenous administrations of DMSO (0.5-0.8 g/kg body weight) showed that with this method of administration of the drug, the treatment time for patients with pleural and lung empyema treated conservatively is reduced.

The volume of intravenously administered (single) 10-20% dimexide solution can be 50-100 ml when treating patients with chronic inflammatory lung diseases.

Can be used for inhalation in the form of a 50% solution.

Intramuscular administration of DMSO solutions does not cause interstitial damage, as evidenced by the absence of enzymeemia, which naturally occurs when cells and tissues are damaged.

A therapeutic mixture of 3-5% DMSO solution with an antibiotic is infused intrabronchially.

The drug is administered, if necessary, intraperitoneally, in the form of a 40-50% solution containing an antibiotic. The volume of injected solution can reach 1 liter. Calculations are based on a dose of 5 g of DMSO per 1 kg of patient body weight.

The drug prepared in this way can also be used for packing cavities. After administration of the drug, a feeling of warmth appears in the cavity. Treatment with this method is well tolerated.

DMSO is excreted from the body mainly through the kidneys with urine. The half-life is 6-8 hours. Only 3% of the drug is excreted through the lungs with exhaled air.

Possible complications

DMSO is practically free side effect. LD/50 - from 3 to 25 g/kg weight. In therapeutic doses it is practically harmless.

Has very low toxicity. Should be considered as a non-toxic compound. Does not have a cumulative effect. The sublethal dose for intravenous administration is 500 mg/kg body weight. However, it may potentiate the toxic effects of others medicines. Strengthens their pharmacological activity by about 7 times. Increases the physiological effects of alcohol by 2-3 times. Has no side effects. Complications with the use of DMSO are rare.

Possible colic in the abdomen, nausea, chills, and sometimes chest pain. However, all these phenomena quickly and independently pass.

Most often, side effects are noted when using the drug on the skin in the form of long-lasting compresses. Diffuse erythema of the skin on the applied area may develop, and a rash may appear. Skin hyperemia, dermatitis, dry skin, itching, short-term sensation of warmth and tingling at the application site. Applying a 40-90% DMSO solution to scarified skin causes inflammatory blisters to appear. Skin irritation at the application site goes away on its own within 1-2 days after cessation of cutaneous use.

Sleep disturbance and bad breath may occur. Unpleasant smell interrupts the sucking of mints.

It enhances the effect of drugs administered simultaneously with DMSO, leading to an increase in their toxicity, which should be kept in mind when carrying out combined drug treatment.

It is described that the administration of DMSO leads to an increase in body temperature during the first 1.5-2 hours, but other authors have not confirmed this observation.

When a 50-70% dimexide solution is injected into the cavities for 1.5-2 hours, the patient may feel a burning sensation.

The medicine "Dimexide" is used in the form of compresses for inflammation of the joints. The drug is considered a very strong solvent and facilitates the delivery of other pharmaceuticals through cell membranes. Dimethyl sulfoxide solution is widely used in complex therapy mechanical damage and various pathologies of the musculoskeletal system. To avoid allergies and development adverse reactions, before applying a compress with Dioxidin, you need to carry out skin test for sensitivity.

Benefits of the medicine

Making compresses with Dimexide to treat joints is useful due to the wide spectrum of action of the drug. The molecular bond with water of dimethyl sulfoxide is high, therefore, penetrating into the cell, the drug increases the permeability of membranes. Useful material easier to get into tissues, and waste products come out. The structures of the musculoskeletal system are renewed, their trophism and ability to regenerate improve. The Dimexide compress also has the following therapeutic effects:

• facilitating the transport of molecules of other medications into tissues;
• relief of inflammation and its symptoms;
• relief of muscle and joint pain;
• blockade of pain impulse transmission along nerves;
• protection against free radicals;
• the ability to accumulate in the body and have a long-term effect;
• stimulation of the formation of immune cells;
• prevention of cancer transformation;
• accelerating the removal of toxic decomposition products.

Instructions for use of "Dimexide" for joints

To combat pathologies, ODA "Dimexide" is used externally. Before this, an allergy test is performed:

To test for sensitivity to a drug, you must first dilute it with water.

1. The medicine is diluted with distilled water.
2. Soak a cotton swab in the solution.
3. Apply to inner surface forearms.
4. After 15-30 minutes. evaluate for redness, itching or rashes.
5. If there are no changes on the skin, the medicine is approved for use.

Bursitis and synovitis

To relieve inflammation and pain in the joints, make a compress with Novocaine. The Dimexide solution is diluted with an analgesic in a ratio of 1 to 3. Then a piece of sterile gauze soaked in the mixture is applied to the knee or other joint. Cover the top of the compress with cling film and wrap it with a warm scarf. After half an hour, the bandage is removed. You need to repeat the procedure for up to 10 days, 1-2 times a day.

To quickly cure bacterial inflammation, antibiotic powder is sprinkled on a bandage soaked in Dimexide and applied to the elbow, shoulder or hip joint.

For deforming arthrosis

In the initial stages of pathology, the use of Dimexide is indicated to relieve pain and restore trophism of the affected cartilage. Instructions for use for arthrosis:

For a compress, gauze is moistened in a solution of the drug.

1. Mix an equal amount of Dimexide and chilled boiled water.
2. Fold a piece of sterile gauze or bandage into several layers.
3. Soak the cloth in the solution.
4. Place gauze on the knee or other affected area so that the bandage completely covers the affected area.
5. Cover with a piece of cling film and secure with several rounds of bandage.
6. Keep the compress for 20-60 minutes. The duration of the procedure is determined by the doctor based on the stage of arthrosis.
7. "Dimexide" for joints is prescribed for 15-20 days.

For injuries of varying severity

For treatment knee joint For injuries, it is recommended to apply a compress. This will speed up the resorption of hematomas, restore mobility and prevent the development of inflammation. For bruises, use 50% Dioxidin, and in case of damage to the integrity of the skin, a concentration of 10-20% is taken. For ankle sprains, you can prepare a compress solution from dimethyl sulfoxide with water and 2 Aspirin tablets. The damaged joint is covered with gauze napkins, wrapped in cellophane and warm cloth. When stretched, the compress is kept for 10-20 minutes. and take it off. Repeat once for 5-7 days. To enhance the effect, the damaged joint should not be loaded.

For rheumatoid arthritis

To properly apply applications to inflamed joints, you need to dilute dimethyl sulfoxide liquid for joints with water in a 1:1 ratio. Compresses with Dimexide for arthritis are combined with hydrocortisone or dexamethasone. Algorithm for preparing a dressing for rheumatoid arthritis:

1. Combine Dimexide with Novocaine and water.
2. Add liquid hydrocortisone in a volume of 2 ml.
3. Soak a gauze pad in the mixture and place it on the knee joint.
4. Cover with compression paper and wrap with a warm cloth.
5. Leave the lotions on for half an hour.
6. Use the product for 12 days.

Traditional medicine also offers another compress recipe:

1. The juice of one medium onion is combined with 5 ml of honey.
2. Grind 3-4 Aspirin tablets.
3. Pour in 4 ml of Dioxidin.
4. The rub is thoroughly mixed and applied to the bandage.
5. The gauze is covered with cling film and fixed.
6. The effect of the composition lasts for a long period of time - 2-8 hours.
7. Individual sensitivity to Dimexide and honey is taken into account.
8. Applications are made once a day for 14 days in a row.

As an alternative, Menovazin is used to relieve pain and relieve inflammation.

_________________________________Hi all!___________________________________________

_________________________________________________________________________________________

I want to talk to you about something so dangerous, but at the same time effective drug as dimethyl sulfoxide. It is also popularly called, more simply, dimexide.

2. Release form, organoleptic characteristics, price, etc.

3. Indications for use

4. Contraindications

5. Side effects

6. Conclusions

1. Pharmacological action

Dimexide is a drug for external use that has antibacterial, analgesic and anti-inflammatory effects.

Penetrates the skin through the mucous membrane, thereby increasing its susceptibility to the penetration of other drugs into it.

2. Release form, organoleptic characteristics, price

On sale you will find dimexide in 3 types:

1) gel or ointment 25%;

2) ready-made solution for external use;

3) concentrate for preparing the solution, 99%

I have a concentrate for preparing a solution.

Unfortunately, there is no box left, but I found it on the Internet

What is a concentrate?

A concentrate, in my understanding, is something that must be diluted with something and in no case used in pure form, otherwise it can lead to very sad consequences.

Dimexide can be diluted plain water or various oils(vegetable, olive, burdock, etc.)

It is sold in a pharmacy. The price is about 100 rubles.

The packaging design can be any. But the following information remains unchanged:

Drug name: Dimexide;

Release form: concentrate for preparing a solution for external use, 99%

Manufacturer: OJSC "Tatkhimfarmpreparaty" Kazan

Mode of application: external

Volume: 100 ml

Storage conditions: store in a dry place, protected from light.

Sell ​​by: 09.2016

Consistency.

transparent oily liquid, colorless.

Smell.

chemical, reminiscent of garlic. When I use dimexide, the taste of garlic automatically remains in my mouth.

Available without a doctor's prescription.

3. Indications for use

Dimexide is most widely used for:

Inflammatory skin diseases;

Systemic scleroderma;

Purulent wounds;

Erythema nodosum;

Furunculosis;

Thrombophlebitis;

Pustular skin diseases;

Erysipelas;

Trophic ulcers.

According to the instructions, Dimexide is also used for diseases of the musculoskeletal system:

Traumatic infiltrates;

Rheumatoid arthritis;

Ankylosing spondylitis;

Arthropathy;

Sprain;

Deforming osteoarthritis;

Radiculitis;

Due to its main property - promoting the best penetration of nutrients and active substances into the skin, dimexide is actively used in hair masks.

I learned about these masks back in 7th grade. At that time my hair was very short and I wanted to grow it at any cost. It looked something like this

And then I quickly rewrote the recipe for this mask in my clumsy handwriting

For those who don’t understand, I’ll decipher it:

Hair growth mask

Ingredients:

• dimexide
• vitamins A, E in oil
• lemon juice

Mix all the ingredients, 2 teaspoons each, apply to the roots of your hair, wrap your head in a plastic bag and put on a hat. Keep for an hour. Wash off with shampoo 2-3 times. Do this mask once a week for 2 months.

Some of my explanations:

1) Dimexide, of course, is diluted with water or oils in a 1:2 ratio and stirred well.

As you can see, this is not written in the recipe. and I didn't bother to read the instructions for it. And then I experienced all the delights of blisters on my forehead, T So rule number 1: be sure to dilute dimexide!

2) be sure to wash it off 3 times to be sure. Oil masks are very difficult to wash off and it is impossible to do it in one go. For example, I washed it off just once and the next day I came to school with blisters and greasy hair...

Rule No. 2: wash off the mask properly, don’t skimp on shampoo!

As a result, after the first time of use, I was disappointed in the mask and abandoned it for several years.

I only remembered about it when I was 18 years old after an unsuccessful carving session. I bought dimexide again, but this time I turned the entire Internet upside down so as not to get into trouble in the same way.

And I realized: dimexide can be added to absolutely any hair mask. That's what I started doing.

I used this recipe:

Vitamin E solution in oil – 1 tbsp. l. Castor oil - 2 tbsp. l. Burdock oil - 2 tbsp. l.Vitamin A – 1 tbsp. l. Dimexide - 1 tbsp. l.

I added everything that was in the refrigerator and was good for hair: eggs, oils, honey, aloe juice, even store-bought alerana.

So a year passed. My hair has changed to this state:

My hair grows by 22 cm per year. On average, a person grows 12 cm per year. Thus, with the help of this mask, my hair growth per month was 1.8 cm, almost 2 cm. Very much so. I recommend a mask with dimexide.

MY SECOND METHOD, COMPLETELY DIFFERENT FROM THE FIRST, BUT NO LESS EFFECTIVE,

I won't torment you. Dimexide perfectly removes glue from any surface!

In my case, I washed the glue from the laptop. Don't ask how it happened, but the stain was quite large and spoiled the whole look

I read this on the great Internet.

You need to moisten a cotton pad in dimexide and vigorously rub the stain for several minutes.

and after a few minutes the stain was wiped off!

Only a small but tasty drop was not wiped off, which I will continue to rub. But, as you can see, there is a result.

But again it was a mistake.

BE SURE TO WEAR GLOVES!

Otherwise, this will happen:

and nothing helps, I’m waiting for it to go away on its own. It does not hurt, does not itch, and does not cause discomfort.

In addition to wrinkled skin on your fingers, you will ruin your manicure. Dimexide corrodes varnish

4. Contraindications

According to the instructions, Dimexide is contraindicated for:

Hypersensitivity to the active substance;

Cardiovascular failure;

Impaired liver or kidney function;

Angina pectoris;

Stroke;

Cataract;

Glaucoma;

Severe atherosclerosis;

Comatose states.

Dimexide is contraindicated in children under 12 years of age, during pregnancy and lactation. Elderly people are prescribed with caution.

5. Side effects

Sometimes allergic reactions, itching, redness, dizziness, insomnia or muscle weakness. If there is poor perception of the drug in in some cases Dry skin, nausea or bronchospasm may occur.

Well, in addition to the side effects, don’t forget about burns!

These are the blisters I had on my forehead after the mask.

And on the right is my hand: I scratched it lightly with my other hand, which was in dimexide, and behold, irritation.

God forbid you burn an area of ​​skin; immediately, to avoid pain and burns, place the area of ​​your body under a stream of ice water.

Thus, dimexide is really effective, but dangerous drug. Use it strictly according to the instructions and then it will benefit you! I'm taking off a star for the burns.

Dimexide has several properties that may make it one of the most important products in the treatment of cancer. It is a powerful free radical fighter and a master detoxifier. It can penetrate body tissues and individual cells, transporting other drugs with it.
Dimexide is anti-cancer on its own and becomes even more powerful when combined with other anti-cancer drugs. Any of these important properties of dimexide may be effective in treating cancer. Excellent results are obtained by treatment with dimexide in combination with laetrile Vitamin B-17 or amygdalin). Dimexide has been used in combination with laetrile to treat cancer since the 1970s. The combination of laetrile and dimexide, administered through a slow infusion, was first formally used by Elmer Thomassen, M.D., of Newport Beach, California, in 1977. The dropper contained: Dimexide - at the rate of 1 gram per 1 kg of body weight of the cancer patient, Laetrile - 6 grams, Vitamin "C" - 25 grams. Each infusion lasted 4 hours. IVs were placed five days a week for five weeks. After completing the course of treatment, the cancer patient took 60 grams of aloe vera juice with one teaspoon of dimexide, once a day.
Many doctors in the US, Mexico and other countries have reported success using laetrile and
dimexide in the treatment of patients with brain, liver, pancreas and other cancers that were considered fatal. These doctors say this treatment is usually more effective than chemotherapy or radiation.

Safety

Dimexide is one of the safest products ever used in medicine. It has been used by millions of people in the US and other countries, and there has not been a single case of death or serious injury. Now compare. The number of drug-related deaths in the United States is estimated at more than 200,000 per year, making drugs the third of the four leading causes of death. Even common painkillers called non-steroidal anti-inflammatory drugs (such as Advil, Mortin, Aleve and aspirin) account for about 7,600 deaths in the US each year. Taking this into account, it can be argued that dimexide is one of the most safe substances in the world today. The classic toxicity test, the LD-50 test, measures the lethal dose at which half of a group of test animals will die. This test for aspirin and dimexide shows that aspirin is seven times more toxic than dimexide.

Side effects: When 60-90% dimexide is applied to the palm, the skin may remain wrinkled for several days. The garlic-like body odor and taste in the mouth are due to a specific metabolite (metabolic intermediate) of dimexide: dimethyl sulfide, a component of natural onion and garlic flavor. It can last from one to two days, and in a small percentage of people, especially men, the odor can be very strong. Drinking enough water will help dispel the odor. Other side effects of dimexide - such as stomach upset, headaches, nausea and sedation - are related to detoxification reactions. When dimexide is diluted with water, heat is generated. The bottle will be warm. This is a temporary, safe reaction.

Warning: Solutions of industrial dimexide contain admixtures of acid and acetone. Such dimexide cannot be used. Acetone can cause serious medical consequences. Long-term exposure to acetone can cause liver damage and death. Beware of this problem when you buy unreliable dimexide. Buy dimexide for medical purposes only from reliable suppliers.

A pure solution of dimexide becomes solid (like ice) in the refrigerator (not the freezer) within 2 hours. Harmful impurities do not have time to freeze during this time. If the bottle is turned over, small streams of poisonous water will flow through the ice. We only need ice in the bottle. To melt its crystals, carefully heat the bottle with the drug in a water bath (water temperature is about 60 ° C). When 50 percent remains unfrozen, the vial is removed and the remains are melted. The resulting dimethyl sulfoxide is almost odorless. The drug at a concentration of 26% inhibits the growth of all microorganisms in the blood of cancer patients. The use of DMSO in oncological practice is facilitated by its ability to conduct to the tumor and accumulate antitumor drugs in it.

Sulfur: The Substance of Life. When salt-rich ocean water evaporates, it is oxidized into dimexide. It then dissolves in atmospheric moisture, is captured by clouds and falls to the ground as rain or snow. Dimexide is found in all cells of the body. Sulfur is vital for numerous chemical reactions related to the detoxification of medications and other harmful toxins. Dimexide has about 40 pharmacological properties that can be useful in the treatment of many diseases. Garlic is a powerful healing agent mainly due to the sulfur it contains. Dimexide is effective for the same reason. In fact, this colorless, oily-looking liquid has a garlicky odor due to its sulfur content. The body uses sulfur to constantly create new cells and replace old ones. Without it, the body will produce weak and dysfunctional cells. Sulfur is also needed to maintain the permeability of cell membranes. For detoxification, it is important to ensure that nutrients enter the cell and toxins and waste products leave it. Sulfur is essential in the formation and maintenance of connective tissue, fighting inflammation, and maintaining a strong immune system. Sulfur deficiency is common due to the fact that sulfur is lost after food is processed. This results in slow wound healing, scar tissue, brittle nails and hair, digestive problems, inflammation, lung dysfunction, decreased immunity, arthritis, acne,
depression, memory loss.

Therapeutic properties. According to medical and pharmaceutical literature, dimexide has perhaps the widest spectrum therapeutic actions ever demonstrated by one chemical. Dimexide is useful for a wide variety of diseases and performs various functions. Dimexide has such
properties: analgesic, anti-inflammatory, bactericidal, antiviral, antifungal, vasodilator, fights free radicals, stimulates Various types immunity, diuretic. In addition, dimexide is capable of transporting various medications through cell membranes, fights blood clots, acts as a tranquilizer (sedative) when rubbed into the skin, stimulates wound healing, creates interferon (proteins secreted by body cells in response to viral invasion), increases the effectiveness of antifungal and antibacterial agents and has a lot of
other benefits.

Hydration: Dimexide is a solvent with an uncanny ability to penetrate the skin. Dr. Jacob explains that dimexide is the “alter ego” (translated from Latin as “another self”) of water. Its molecular bond with water is 1.3 times stronger than the molecular bond of water with water. As a result, it displaces water as it moves through cell membranes, and transports with it substances that normally cannot penetrate the cell on their own.

Painkiller: In his book “Dimexide: Natural healer", Dr. Morton Walker states that people now have a new breakthrough in the fight against pain: dimexide. Some researchers believe that dimexide "could become the aspirin of the 21st century." Despite the fact that all the mechanisms of the substance are not yet fully known, it is assumed that its action is that it blocks C fibers peripheral nerves, which receive pain signals.

Free radicals: Dimexide is one of the most powerful free radical fighters known today, and perhaps the most powerful. Some molecules in our body produce an unequal number of electrons and this instability causes them to destroy other cells. Dimexide attaches to these molecules and then they are excreted from the body with dimexide. Dimexide replaces water in cells and thus treats diseased cells by destroying free radicals inside it. Thanks to these properties, dimexide is useful in the treatment of various diseases, including cancer, arthritis, and atherosclerosis.

Bioavailability: Dimexide applied to one area often results in decreased pain or various improvements in other places because of it general action. Due to its ability to penetrate, dimexide can carry healing properties deep through the tissues of the body. Another unusual property of dimexide, which greatly distinguishes it from other substances and drugs, is that it has a cumulative effect and does not require large doses.

Transporter & Dimexide acts as a transporter for other substances or drugs, and it can also enhance their effect. In fact, certain drugs diluted with dimexide, such as corticosteroids, antibiotics and insulin, can be used in lower doses than usual without reducing their therapeutic effectiveness and in addition their unwanted side effects are greatly reduced.

Immunity: Dimexide strengthens the immune system by increasing the production of white blood cells and macrophages, which destroy foreign substances and pathogens in the body. Dimexide activates macrophages, which makes them especially deadly against harmful microorganisms and cancer cells. Dimexide reduces allergic reactions by opening cell membranes and allows special antigens, substances that
stimulate the production of antibodies in the body. This process creates immunity to infectious diseases and the growth of malignant tumors.

Radioprotective properties: Dimexide is a classic sulfur compound. Sulfur has a long history of use as an antidote against acute injury from radioactive materials. A Japanese study showed that even small concentrations of dimexide have radioprotective effects. They help repair DNA double-strand breaks, and thus provide protection against radiation damage at all cellular levels of the body.

Frost-protective properties: Dimexide also has frost-protective properties. This means that it is able to protect against damage caused by frost. Before dimexide, there was no way to preserve organs without forming ice crystals that killed the tissue. In 1961, Dr. Jacob first became acquainted with the antifreeze properties of dimexide. Preserving organs for transplantation is still one of the many uses of dimexide. 100% dimexide will freeze at temperatures around 19°C, while a 50% solution of dimexide and water will not freeze at temperatures far below the normal freezing point
water.

Detoxification: Heavy metals (mercury, lead, aluminum, cadmium, arsenic, nickel) are very difficult to remove from the body and they cause many diseases. Dimexide may help in detoxification from heavy metals. Sulfur is a mineral and the main ingredient of certain amino acids that binds to heavy metals (mercury, lead, aluminum, cadmium, arsenic, nickel) and removes them through urine, bowel movements and sweat. Dimexide (injected intravenously) helps eliminate amyloid proteins (Amyloidosis), which are the cause of Alzheimer's disease.

Methods of using the drug

Commercially available brands of DMSO vary widely in quality. Therefore, DMSO should only be used under the supervision of specialists who are familiar with
its properties and know how to use it. DMSO will carry whatever is on your skin into your bloodstream. Wash and rinse the area where you will apply it thoroughly. The same goes for your hands. Dimexide is usually applied to the skin in the form of a liquid, gel or cream. It can be taken by mouth or through an intravenous injection (in many cases, along with other medications). It is also prescribed subcutaneously, intramuscularly, intraperitoneally, intrathecally, through inhalation, to mucous membranes and into the bladder. Dimexide can also be instilled into the eyes. Concentrations and doses vary widely. People with white skin, blond or red hair and blue eyes are more sensitive to dimexide. For these, surface, oral or intravenous concentrations should be 50 percent or less, especially around the face and neck. Dimexide applied to the skin is completely absorbed after 4-8 hours. Dimexide taken orally reaches peak blood levels after 4 hours. In general, absorption through the skin is slightly less than through the digestive tract. Dimexide cannot quickly penetrate nails, hair or tooth enamel.

Surface application: The liquid form of dimexide is the most effective form of applying dimexide. It is advisable to begin superficial treatment with dimexide with low concentrations until the skin gets used to it over time. For any superficial use of dimexide, the skin must be clean, dry and undamaged. The face and neck are more sensitive to dimexide and therefore concentrations higher than 50% should not be applied to them. In areas where circulation is reduced, surface concentrations of dimexide should be below 70%. If 60%-90% dimexide is applied to the skin, warmth, redness, and tingling may occur. This usually goes away within a couple of hours. To prevent this effect, you can use natural aloe vera, gel or cream. In general, after superficial treatment with dimexide, it is recommended to apply aloe vera cream to the area, regardless of whether there is irritation on the skin or not.

Oral administration: The usual dose of dimexide for oral administration is 1-2 teaspoons (5-10 ml) per day. Dimexide is usually mixed with tomato or grape juice to disguise it bad taste. It is advisable to first start with half a teaspoon of dimexide and gradually increase (if any possible detoxification reactions are tolerated normally).

Intramuscular administration DMSO solutions do not cause interstitial damage, as evidenced by the absence of enzymeemia, which naturally occurs when cells and tissues are damaged. A therapeutic mixture of 3-5% DMSO solution with an antibiotic is infused intrabronchially. The drug is administered, if necessary, intraperitoneally, in the form of a 40-50% solution containing an antibiotic. The volume of injected solution can reach 1 liter. Calculations are based on a dose of 5 g of DMSO per 1 kg of patient body weight. A drug,
prepared in this way can also be used for plugging cavities. After administration of the drug, a feeling of warmth appears in the cavity. Treatment with this method is well tolerated. As in local application, and in the form intravenous injections it promotes wound healing, relieves pain, prevents cell damage and improves disease symptoms. However, to pay for the healing effects of DMSO, those who use it must put up with an unusual side effect - a very unpleasant one.
the smell that their breath and body emit. This garlic-like odor is certainly one of the reasons why DMSO is not used.

Intravenous injections: Dimexide is not a drug for external use only. A 10-20% solution is administered intravenously at a rate of 0.5-0.8 and
even 1 g/kg weight. Intravenous administration should be carried out slowly, using an isotonic sodium chloride solution. The drug can be administered intravenously in combination with other drugs. The volume of intravenously administered (single) 10-20% dimexide solution can be 50-100 ml when treating patients with chronic inflammatory lung diseases. Up to 20 cubic cm of dimexide 25% concentration (dimexide must be diluted with sterile water), administered through intravenous
injection by a specially trained doctor to treat more serious degenerative diseases. Intravenous injection is done by slowly pushing the entire volume into the bloodstream at one time.

Intravenous drip (infusion): A slow intravenous drip is administered over 2-3 hour periods. 50-100 cc of dimexide added to 500 cc of glucose or saline solution is instilled into the patient’s arm vein. This method should only be performed by a qualified doctor.

Emergency medical assistance: Dimexide has certain properties that make it a very valuable agent in the treatment of victims of serious accidents or sudden serious illnesses such as heart attacks. Dimexide reduces swelling, is anti-inflammatory, increases oxygen supply, fights free radicals and helps protect cells from mechanical damage.

Inflammation. Inflammation is the body's complex response to injury or tissue destruction. In its acute form, it can be characterized by the classic signs: pain, swelling, heat, redness and loss of function. Dimexide works as a powerful anti-inflammatory agent. It can minimize all symptoms of inflammation. Patients' tumors shrank and localized heat cooled to normal. Patients also often noticed an immediate reduction in pain.

Additional recommendations: Numerous studies have revealed the amazing ability of dimethyl sulfoxide to easily penetrate the blood and human body through intact skin. 5-6 minutes after application to the skin, the presence of DMSO molecules is detected in the blood. The maximum concentration in the blood is created after 4-6 hours and decreases slowly over 36-72 hours. Action active medicinal substances intensifies because many of them directly enter the bloodstream, bypassing the digestive organs. Thanks to the powerful improvement in the permeability of drugs through the skin, their concentration contained in various ointments and rubs can be reduced several times! Thus, it has been proven that if about 20% DMSO is added to prednisolone ointment, then the concentration of prednisolone (without reducing therapeutic effect) can be reduced by 8-10 times! This means not only significant savings on expensive drugs, but also a sharp decline the risk of unwanted side effects when treating patients. Dimexide has strong anti-inflammatory, antipyretic, antimicrobial, antifungal properties. As
30-50% solutions are used for diseases of the musculoskeletal system (rheumatoid arthritis, arthrosis, radiculitis, bruises and sprains, myositis,
traumatic infiltrates). And also for inflammatory skin diseases (furunculosis, erysipelas, purulent wounds, burns, thrombophlebitis).

Dimexide is one of the best remedies in the treatment of joint contracture - stiffness that develops as a result inflammatory process. Applied to the skin in the area of ​​inflamed joints and easily penetrating inside, DMSO relieves inflammation of the periarticular soft tissues and muscles. Dimexide accelerates wound healing and restores the activity of antibiotics in cases where microbes have already developed resistance to them, increases the body's resistance to low temperatures and radiation exposure.

The purified drug showed good results in secondary renal amyloidosis, a severe complication. rheumatoid arthritis, accompanied by the deposition of insoluble protein in the kidneys. In this case, dimexide was administered orally, diluted 10-15 times with distilled water (1 tablespoon 2-3 times a day after meals). In the same form, the drug was used after irradiation of the pelvic organs and rectum (in connection with the treatment of malignant neoplasms). This allows you to relieve reactive tissue inflammation after radioactive exposure and protect healthy cells.

At home, you can prepare tinctures, balms and ointments based on dimexide to treat a wide variety of pathologies, even in severe, advanced cases.

To prepare tinctures, use frozen pharmaceutical dimexide, which, if necessary, is diluted boiled water up to a concentration of 30-70%. Based on 25-30% solutions of dimexide, you can prepare tinctures of chamomile, meadowsweet, salvia officinalis, St. John's wort, thyme and many other medicinal plants. All such tinctures are mainly used externally. If you are performing this procedure on someone other than yourself, you must wear rubber gloves to protect your own skin. Use during pregnancy and breastfeeding is contraindicated.

Externally (applications, irrigations). Apply gauze pads moistened with a diluted (1:1) solution to the affected areas once a day (for 20–30 minutes). For the skin of the face and other highly sensitive areas, more diluted solutions (1:10, 1:5, 1:3) are used (the same solutions can be used to wash purulent-necrotic and inflammatory lesions and cavities). A plastic film and cotton or linen cloth are placed on top of the napkin. Course - 10–15 days. Storage conditions for the drug Dimexide: in a dry place, protected from light. Keep out of the reach of children.

How to dilute Dimexide? Dimexide liquid concentrate must be diluted with water before use to obtain a solution of the required concentration. Undiluted concentrate causes chemical burn skin. Most often, Dimexide is diluted with water in a ratio of 1:3 or 1:4 (one part Dimexide, 3 or 4 parts water). But sometimes the doctor prescribes other dilutions of Dimexide for treatment. They are prepared as follows:

Solutions obtained by diluting the concentrate are used for compresses, applications, tampons and rinses (irrigations).

Both when applied topically and as an intravenous injection, it promotes wound healing, relieves pain, prevents cell damage, and improves symptoms wide range autoimmune diseases. DMSO can be used for so many different problems - from sprained ankles to arthritic pain and
previously considered incurable bladder dysfunction - that it is simply unbelievable. More than forty thousand studies have been devoted to DMSO, and many of them
were focused on him beneficial effect on human health.

Opponents of dimexide. First of all, these are the FDA (US Food and Drug Administration) and large pharmaceutical companies. Dimexide
sold in stores healthy eating, on the Internet and most of the world. It has been used by millions, but in the US, dimexide is approved by the FDA only as a preservative.
stem cells, bone marrow cells and organs for transplantation, as well as for interstitial cystitis - painful inflammatory disease urinary
bladder, which is very difficult to treat with other therapies. Dimexide is very cheap to produce. No drug company can obtain an exclusive patent because
this is also natural compound Therefore, these companies will not be able to make significant financial profits. The president of a major pharmaceutical company said: “We don’t care that dimexide is the main drug of our century and we all know it, it’s just not worth anything to us.” Despite restrictions on the use of dimexide, thousands of Americans buy it on the black market every year , its popularity is not due to advertising, but thanks to the people who have benefited from dimexide. When you have something that cures all types of illnesses, including some incurable and life-threatening ones, people naturally recommend it to friends and family.