The child’s immune system controls all processes that occur in his body. It not only protects against influence external factors─ viruses, bacteria, fungi. Immunity regulates consistency internal environment body.

Polyoxidonium ─ immunomodulator, a synthetic drug that restores defenses. Its composition is similar to substances produced by itself. immune system and strengthen its response mechanism. This is a corrector of the body's internal defenses.

Polyoxidonium is an immunomodulatory agent.

Composition of the drug

Polyoxidonium is a trademark, and the active substance, on which the action of the drug ─ azoximer bromide is based. It stimulates the immune system and removes toxins.

Dosage forms:

Mandatory additional components for all release forms:

• mannitol ─ it acts as a diuretic, increases the volume of urine, which reduces intoxication during influenza or ARVI;
• povidone ─ binds toxins into complexes and removes them through the intestines;
• Betacarotene is an analogue of vitamin A, stimulates the immune system, adapts the child’s body to fight infection.

Additional components in the tablets;

• lactose monohydrate ─ used as a filler, improves metabolic processes, normalizes intestinal microflora, stimulates the nervous system;
• potato starch ─ filler for tablets;
• stearic acid ─ stabilizer for solid forms.

Basis for rectal suppositories─ cocoa bean butter.

Pharmacological action of the drug

Polyoxidonium increases the child’s body’s resistance to local (the pathogen is located on the mucous membranes) respiratory tract) and generalized (the virus has spread throughout the body) infection.

Doctors advise taking the drug if you have a weak immune system.

The drug directly affects phagocytes, cells that absorb viruses, and stimulates the formation of antibodies.

Polyoxidonium restores the protective mechanisms of the baby’s immune system, which are disrupted in the following conditions:

• infections;
• burns;
• injuries;
• tumors;
• complications after operations;
• chemotherapy.

The medicine is active removes toxins from the child's body. This is ensured by its molecular structure.

Indications

The drug is prescribed to children from 6 months.

As an independent remedy, Polyoxidonium is prescribed to children with recurrent herpes infections. It is also prescribed for seasonal prevention of ARVI and influenza 2-3 months before the expected epidemic.

Polyoxidonium will help with relapses of herpes.

Indications for use of the drug in the composition complex therapy:

• severe forms of bacterial, viral, fungal infection;
• frequent relapses of chronic infectious diseases in the stage of exacerbation or remission;
• allergic diseases ─ bronchial asthma, hay fever,;
• inflammatory processes of the urinary tract;
• all forms of tuberculosis, rheumatism;
• non-healing burns, ulcers, complicated fractures;
• chemotherapy;
• protection of the kidneys and liver from the effects of toxic pharmacological agents;
• frequency of colds more than 6 times a year.

Cautions:

• Newborns and babies under 6 months cannot be treated with the drug. Prescribed with caution if little patient serious illnesses kidney Possible risks must be taken into account.
• If treatment does not deviate from the prescribed regimen, then the likelihood side effects zero.

Anatoly Sergeevich Kuznetsov, pediatrician, doctor highest category from Volgograd recommends:

"In my many years medical practice I had to deal with serious violations in the functioning of the immune system of children. Every year there is a growing trend of immune deficiency in the youngest patients. In addition to general strengthening measures, there was a need for medicinal adjustment of the body’s protective functions. Polyoxidonium has proven itself as effective drug to restore immunity. Unlike its analogues, it has no side effects, is safe and is well tolerated by children.”

The drug is well tolerated by children of different ages.

Margarita, Nizhny Novgorod, writes:

“My child underwent surgery. The condition was serious. Long bed rest. To restore strength and maintain the body, the attending physician prescribed Polyoxidonium for us. Improvement in the condition became noticeable already on the third day. Recovery and rehabilitation were easier and faster than we had predicted. When he was discharged home, the baby felt well. Thanks to the doctor and the drug."

Manufacturer and prices

Polyoxidonium was created in Russia. The production license belongs to NPO Petrovax Pharm LLC.

Prices (average values):

1. Lyophilisate:
   • 3 mg ─ 629-697 rub.;
   • 6 mg ─1110-1192 rub.
2. Candles:
   • 6 mg ─ 830-900 rub.;
   • 12 mg ─ 1015-1110 rub.
3. Tablets ─ 715-760 rub.

Dosage

The drug is available in different forms, so the dosage is easy to select for young patients of any age.

Candles

This form is most suitable for children under 6 years old. At this age, they cannot swallow the tablet on their own, and there is still a risk of it getting into the respiratory tract. Candles ─ good alternative for the baby, so as not to give pills. The drug is absorbed faster in the rectum than in the stomach, therefore the effect occurs immediately. The torpedo-shaped shape makes insertion of the suppository quick and painless. Cocoa butter gives a slight scent.

Children under 12 years of age are prescribed suppositories ─ 6 mg, at night, preferably after bowel movements. The average course of treatment is 10-20 suppositories. The regimen is prescribed by the doctor on an individual basis.

For the treatment of children, suppositories are most often prescribed.

Lyophilisate

Lyophilisate ─ is a dry substance for preparing medicinal solution. Lyophilization is a method of soft drying of a substance, which allows one to obtain a dry drug without loss of biological activity.

The color of Polyoxidonium ranges from white to bright yellow. Crystals are sensitive to sunlight, easily absorb and retain atmospheric moisture upon contact with air. To prevent the medicine from spoiling, you must follow the storage rules prescribed in the instructions for use. A solution for drops and injections is prepared from the powder.

Intramuscularly or intravenously, the dose is calculated by the doctor taking into account the child’s weight. Course ─ 5-10 injections.

You can prepare nasal drops yourself at home. The bottle (3 mg) is diluted in 1 ml of saline solution (NaCl 0.9%), distilled or boiled water. Drop 1-3 drops into each nostril or under the tongue up to 4 times a day.

The finished drops are stored for a week in the refrigerator. Duration of treatment is up to 10 days. Usually improvement occurs on the fourth day.

Lyophilisate is used as part of complex therapy for the prevention of acute respiratory infections and influenza.

Pills

The tablets are cylindrical and flattened in shape. Color ─ white, yellowish, impurities are allowed (orange inclusions). Dosage - 12 mg.

Take 1 tablet half an hour before meals 1-3 times a day. The course of treatment for colds is 10-14 days. Prophylactic intake for 3 weeks.

Attention! If the doctor has prescribed pills, the child must take them strictly in the presence of parents and under their supervision.

The tablet can be swallowed or placed under the tongue until completely dissolved.at

Anna from Moscow writes:

“I am the mother of two children, 4 and 7 years old. Life in a metropolis ─ This is a constant fight against all kinds of infections. With the onset of cold weather, my sons suffer from colds almost continuously. The youngest has frequent sore throats with high temperature. Our Family doctor I advised Polyoxidonium, suppositories and nasal drops. The result was not long in coming. After a two-week course of treatment, the boys feel great. Now we will take the drug in tablets for prevention.”

Advantages of the drug

The drug has been used in pediatric practice since 2004. Long-term observations during the treatment of children led to the conclusion that, in comparison with other immunomodulators, Polyoxidonium has the following advantages:

• increases efficiency complex treatment recurrent infections and immunodeficiency diseases;
• accelerates the healing process;
• reduces the need to use antibiotics for illnesses moderate severity;
• reduces the incidence of ARVI in children in the autumn-winter period;
• promotes the removal of sputum during viral diseases respiratory tract, acts as an expectorant.

The drug accelerates the discharge of sputum during bronchitis.

The most common misconceptions about the effects of Polyoxidonium on the children's body

• It is mistakenly believed that the drug interacts with the cells of the body and increases the rate of their division. And supposedly as a result there is too intense physical development baby.
• The unfounded opinion that when long-term use Polyoxidonium provokes the development of cancer.
• Another misconception is that the child’s body perceives the components of the medicine as foreign substance, as a result of which an immune reaction is produced in the form of an inflammatory process and intoxication.
• It is widely believed that medicine causes allergic reactions. Polyoxidonium contains lactose. In some children, this leads to digestive disorders. However, its amount in the drug is insignificant for the development of allergic reactions and intolerance.

Analogues of Polyoxidonium

Preparations with similar action:

• ─ improves the balance of the immune system, relieves inflammation, slows down development tumor process. Assign children from 4 years old for the treatment of colds in the form of tablets or injections. Price ─ 137-806 rub.
• Imunofan ─ suppositories are used to prevent immune deficiency, as part of antiviral and antibacterial treatment. Contraindicated in children under 2 years of age. Release form: suppositories, injection ampoules, nasal spray. Price ─ 485-950 rub.
• ─ a universal drug that not only strengthens the immune system, but also treats many inflammatory diseases. Prescribed from birth. Contraindications ─ allergy to components, age up to 6 months. Release form: tablets. Price ─ 650-1330 rub.

In most cases, problems with immunity manifest themselves when the child begins to attend preschool. Children who were born prematurely or with low birth weight are primarily affected by the attack of a viral infection. High level colds is explained by the fact that babies lack immunological memory.

Polyoxidonium is first aid for the fragile children's body. The fundamental difference between the drug and its analogues is that it is used not only for the treatment of chronic infections, but also for acute viral, bacterial and fungal diseases.

Natalia Avramenko

How to protect yourself from diseases and strengthen your immune system is a problem that scientists from all over the world are thinking about solving. And if earlier we were offered “overseas” options for activating the body’s defenses, today the situation has changed. Pharmacies are full of domestically produced immunomodulators, which are in no way inferior in quality to the achievements of the foreign pharmaceutical industry. And some even surpass them. One of them is the drug Polyoxidonium.

What is so special about Polyoxidonium?

Polyoxidonium is a medicine that many people have most likely heard of. Doctors actively prescribe it to adults and children, not forgetting to mention that nothing better simply exists. What explains such a statement and can it be believed? Let's figure it out together.

Polyoxidonium (unlike other immunomodulators) has a complex effect. It not only helps restore the protective barrier, but also prevents the development of complications, improves general health and removes toxins. The use of Polyoxidonium is justified when nothing else helps.

Before you continue reading: If you are looking effective method to get rid of runny nose, pharyngitis, tonsillitis, bronchitis or colds, then be sure to check out Book section of the site after reading this article. This information has helped so many people, we hope it will help you too! So, now back to the article.

The innovative product effectively resists any infection (bacterial, viral, fungal) and quickly eliminates the manifestations of the disease. It is characterized by high immunomodulatory, detoxifying, antioxidant and anti-inflammatory effects. The main active substance is azoximer bromide.

Polyoxidonium can be distinguished from among immunomodulators for several other reasons:

• quick effect. The result becomes noticeable within a few hours after administration. This is explained by the unique structure of the drug. The Polyoxidonium molecule contains special active groups that instantly absorb harmful microparticles and just as quickly remove them from the body;
• safety. The drug does not contain potentially dangerous antigens or herbal ingredients, often causing allergic reactions. That is, Polyoxidonium side effects does not have;
• versatility. The medicine is prescribed for various pathologies, one way or another associated with changes in the immunological status. An adequate and quick rebuff to the “enemy” will be given in any case;
• diversity dosage forms. Polyoxidonium is available in suppositories, injections and tablets. This allows in every specific situation pick up best option treatment.

The medicine is approved for use by WHO and is even included in the list of vital medicines.

How does the drug work?

Polyoxidonium interacts with the membrane of all immune cells. The generated impulse triggers “sleeping” macrophages, monocytes, neutrophils and NK killers. They begin to actively mark and capture foreign microorganisms, produce interferons and cytokines, and trigger B and T cell reactions. All this helps to increase the efficiency of the immune system - the manifestation of symptoms decreases, intoxication becomes less pronounced, the degree of tissue damage is reduced and ultimately occurs full recovery. In this case, the risk of complications is almost zero.

Polyoxidonium has earned the title of “smart” drug for a reason. He knows how to increase low immunity levels, decrease high ones and have no effect on what is within normal limits.

Polyoxidonium's ability to affect all cells of the defense system explains its high effectiveness against any infection. It is prescribed for viral, bacterial and fungal diseases.

Treatment with Polyoxidonium allows:

• quickly eliminate intoxication syndrome;
• reduce the degree of tissue damage;
• prevent the development of complications;
• get a long-term anti-inflammatory effect;
• reduce the duration of treatment several times;
• prolong remission in the presence of chronic infection;
• reduce at simultaneous administration toxicity of antibiotics, glucocorticosteroids, cytostatics;
• improve performance.

Polyoxidonium becomes the most important “button” for the immune system, launching the process of confronting hostile agents at full power.

A little more about detoxifying properties

Polyoxidonium is the first immunomodulator with detoxifying abilities. At the same time, the property of a detoxifier has nothing to do with the activation of protective forces. The drug is a water-soluble polymer consisting of many units. The introduction of N-oxide groups into the “framework” endowed it with the ability to adsorb (absorb) toxic particles (both dissolved and living) and remove them.

This becomes especially valuable in acute infectious diseases, when it is necessary to revive the patient as quickly as possible. Injections, drops and other forms of Polyoxidonium cope with this task “excellently” - weakness, headache and muscle aches disappear immediately after taking.

Applications of Polyoxidonium

The use of immunomodulators is one of the main stages on the path to recovery, avoiding complications. But in order for the result to be quick and last as long as possible, it is important to choose the right drug. Polyoxidonium is one of the best of its kind. And all because the action of a chemically pure medicine is based on rapid activation hidden forces body.

The general indication for use of the product is decreased immunity. But suppositories, injections and Polyoxidonium lyophilisate have their own indications, i.e. a list of conditions when this form will be most effective.

Tablets are mainly prescribed for diseases of the respiratory system and ENT organs. As a single drug - for the prevention of acute respiratory viral infections, sinusitis, otitis, bronchitis, herpetic rashes.

Polyoxidonium suppositories are used in the treatment of cystitis, pyelonephritis, endometritis, colpitis, atopic dermatitis, hay fever, arthritis, tuberculosis, as well as in the post-traumatic period after burns and fractures.

Polyoxidonium solution in the form of drops and injections is used for the complex treatment of chronic inflammatory infections, regardless of their location. Reading the instructions for using Polyoxidonium in injections, one gets the impression that it is always relevant. There is some truth in this. The immunomodulator is prescribed in combination for the treatment of acute and chronic diseases of the bronchopulmonary system, allergic ENT pathologies, viral, bacterial and fungal infections genitourinary area and intestines.

Polyoxidonium will be the best assistant in the prevention of inflammation, regardless of etiology. Eliminates the side effects of antibiotics, restores immunity in cancer patients and people experiencing excessive psychophysical stress, and helps acclimatize ahead of the holiday season.

Contraindications and side effects

In terms of contraindications, Polyoxidonium is also encouraging. He has a minimum of them (according to the instructions for use). Or, more precisely, two - pregnancy and lactation. Although this is not entirely correct. The list of contraindications must include:

• individual intolerance to azoximer bromide;
• age up to 6 months (for injections and suppositories) and up to 12 years (for tablets);
• relative contraindications are acute renal failure, lactose intolerance, malabsorption syndrome.

Relative contraindications mean conditions when the drug should be taken exclusively under medical supervision.

There are no data on side effects. This modulator is positioned as one of the safest. During the studies, no allergic reactions or toxic effect to the liver or kidneys.

Polyoxidonium does not deplete protective and hematopoietic systems, does not disrupt the natural course of development of the protective reaction, which means it can be used for a long time (several months).

Instructions for use of Polyoxidonium for adults

So, we got acquainted with the drug, found out how it works and when it is prescribed, now the question quite naturally arises, how to take Polyoxidonium? Despite the fact that the product is safe and does not cause side effects, it should be used as prescribed by a doctor. The dosage of Polyoxidonium depends on the disease and the characteristics of its course. But first things first.

Pills

For inflammatory processes of the mouth and pharynx (stomatitis, laryngitis), chronic diseases ear and nasal cavity (otitis, sinusitis) Polyoxidonium 12 mg is prescribed (1 tablet 2 times a day). For respiratory tract infections, 24 mg (2 tablets) twice a day.

For severe lesions of the oral mucosa, herpes, chronic tonsillitis, 12 mg 3 times a day. To prevent influenza, take 2 tablets of Polyoxidonium (24 mg) 2 times a day.

The tablets are dissolved under the tongue or swallowed whole. Take half an hour before meals.

The average duration of prevention and treatment is 5-15 days.

Polyoxidonium suppositories 12 mg are intended for treatment. For prevention, 6 mg suppositories are more often used. Suppositories are inserted into the rectum after bowel movements, and into the vagina 1 hour before bedtime.

For exacerbation of chronic diseases, severe allergic reactions and for the prevention of acute respiratory infections, 12 mg suppositories are prescribed rectally. The first 3 days - every day, then - at 2-day intervals. At acute infection, to speed up recovery after injuries, 12 mg suppositories are used every day. For chronic diseases in remission, rheumatism and to maintain a weakened body during the cold season - every other day. For the prevention of herpes - 6 mg every other day.

For chronic immunodeficiency, Polyoxidonium 6 mg suppositories are administered twice a week, but the duration of administration can vary from 3 to 12 months. In case of secondary senile immunodeficiency, suppositories are also prescribed rectally 2 times a week. For gynecological and urological diseases, 12 mg suppositories are administered daily (3 days), and then 1 suppository every 3 days.

For tuberculosis, the scheme is as follows: first, 12 mg suppositories are used daily for 3 days, then every 2 days. After completing the main course, 6 mg suppositories are prescribed 2 times a week (about 3 months).

Injections

Polyoxidonium injections are most often prescribed to adults. For acute and chronic inflammation respiratory and genitourinary system, herpes, allergic diseases, rheumatoid arthritis, Polyoxidonium 6 mg is prescribed every other day or 2 times a week. A total of 5-10 injections. Administration regimens may vary: 10 injections every other day, the first 3 injections daily, the rest every other day or 2 days, the first 5 injections every day, the rest 2 times a week.

For tuberculosis, in the postoperative period or in conjunction with radiation therapy, Polyoxidonium is prescribed in ampoules of 6 or 12 mg every other day or 2 times a week. Only 10-20 injections. For acute allergies, the drug is administered intravenously.

For patients with renal failure, more than 2 injections per week are not recommended.

Now about how to dilute Polyoxidonium. The solution should be prepared before injection and cannot be stored. Administered intramuscularly. Distilled water or saline solution in an amount of 2 ml is added to Polyoxidonium lyophilisate 6 mg. For intravenous administration Hemodez-N, 5% Dextrose solution, Reopolyglucin or saline solution are added to the lyophysilate ampoule, then this “cocktail” is transferred into a dropper with a volume of 200 ml.

Polyoxidonium for children

Is it possible to give Polyoxidonium to a newborn baby? Will the drug cause any harm? frequent use in older children. Which is better: pills or injections? Will there be allergies, fever and other side effects after Polioskidonium? These are just a few of the questions that concern modern parents. Are you one of them? Then read more carefully.

Polyoxidonium is widely used in pediatric practice. Over 20 years of active use, the drug has managed to win the trust of doctors and parents. Assigned from 6 one month old. A variety of release forms helps the specialist to fully realize individual approach. That is, choose the option that is most effective in a given situation.

It has been proven that respiratory diseases, if they become too frequent, they reduce the body’s defenses, disrupt the functioning of all organs and systems, and lead to the development of chronic lesions. More than 95% of respiratory diseases are viral in nature. On the one hand this is good, but on the other hand it is bad.

Viral respiratory diseases are characterized by a calm course and fast recovery, but often lead to complications. Thus, ARVI and influenza in many young patients turn into pneumonia, sinusitis, otitis, and pyoderma.

Viruses can be present in the body in active or latent form. Their constant presence causes defects in all parts of the immune system.

Immunomodulators will help to avoid the transition of an acute inflammatory process to a chronic one. But the choice should be made correctly - illiterate immunocorrection can reduce or even completely suppress the natural formation of interferons.

Polyoxidonium is a well-studied, proven drug that does not interfere with the body, but gently helps it fight infection. It eliminates immunity defects, quickly triggers defense mechanisms, shortens the duration of illness and eliminates secondary infection.

Instructions for use of Polyoxidonium for children

For children, Polyoxidonium is most often prescribed in drops and in the form of suppositories. Less often - in injections and tablets.

Injections

For injections, Polyoxidonium is used in 3 mg ampoules. Add 1 ml of distilled water or saline solution to the bottle. If it is necessary to administer the medicine intravenously by drip, then 2 ml of Hemodez-N, saline solution, Reopoliglucin are injected into the lyophilisate, shaken and the resulting mixture is added to a dropper with a volume of 150 ml or more.

Polyoxidonium can be prescribed from 6 months. Dosage depends on weight. There should be 100-150 mcg of dry matter per 1 kg. A 3 mg vial contains 3000 mcg. This must be taken into account when administering the drug.

Polyoxidonium injections are painful. The medicine should be administered intramuscularly very slowly. If there is no allergy, add 1 ml of 0.25% novocaine to the ampoule.

For inflammatory diseases in acute stage injections are given every other day. Per course - from 5 to 7 injections. For exacerbation of chronic infections - 2 times a week (10 injections). For acute allergic conditions Polyoxidonium, together with antihistamines, is administered intravenously.

Polyoxidonium in drops for children is the most the best option. Simple and painless.

The drops are prepared as follows: add 20 drops of distilled water (1 ml) to the 3 mg lyophilisate and shake well. All. The drops are ready. They can be stored in the refrigerator for 1 week. One drop contains 150 mcg of azoximer bromide (the main component of Polyoxidonium).

To make it easier to understand how many drops of Polyoxidonium to drip into the nose or under the tongue, use the following daily dosage scheme:

• child weight up to 5 kg - 5 drops;
• from 5 to 10 kg - 10 drops;
• from 10 to 15 kg - 15 drops;
• from 15 to 20 kg - 20 drops.

Please note that the indicated amount is daily, not one-time. Typically, 1-2 drops of Polyoxidonium are dripped into the nose of children every 3-4 hours. The course of treatment is from 5 to 10 days. Also 2 drops under the tongue, but every 2-3 hours. Course - 15-20 days.

Candles

Polyoxidonium suppositories for children 6 mg are prescribed for exacerbation of colds, herpes, and for the prevention of influenza. Administer 1 suppository rectally every other day. The course requires 10 candles. IN severe cases the duration of treatment increases.

Pills

Prescribed from 12 years of age. For the treatment of acute and chronic infections, as well as for the prevention of seasonal colds - 1 tablet (12 mg) morning and evening for a week. The doctor decides how to take the medicine (swallow whole or dissolve under the tongue). In any case, this must be done 30 minutes before meals.

Polyoxidonium in gynecology

Inflammatory diseases of the female genital organs occupy a leading position in gynecological practice. The most common are:

• endometritis;
• pelvic peritonitis;
• salpingitis;
• oophoritis.

Often, inflammatory processes occur in chronic form with vague symptoms. Traditional treatment tactics (using antibacterial agents) are ineffective. This is due both to a change in the sensitivity of the pathogen to the drugs used and a large number of side effects, and to the impossibility of such therapy influencing local immunity.

Immune deficiency develops, the constant presence of the pathogen leads to frequent relapses and infection with other infectious agents, because restoration of the protective barrier does not occur. That is why it is necessary to supplement the prescribed therapy with immunomodulators.

Studies have shown that the use of Polyoxidonium suppositories in gynecology helps:

• normalize menstrual, secretory and reproductive function;
• significantly reduce the presence of pathogens in tissues already on the 2nd day of treatment;
• improve ultrasound performance of the pelvic organs;
• reduce the duration of therapy by an average of 5-7 days;
• reduce the dose of antibiotics;
• exclude the possibility of relapses.

During a control study (after one course of treatment), indicators inflammatory processes are not detected, blood tests return to normal, and the symptoms of the disease completely disappear. It is important to note the following: after 6 months of treatment, relapses of PID ( inflammatory diseases pelvic organs) occur rarely.

Is it necessary to do an immunogram?

Polyoxidonium can be taken without an immunogram. The basis for the appointment will be Clinical signs immune deficiency:

• ARVI more than 5 times a year;
• exacerbation of herpes more than 3 times a year;
• frequent exacerbation of chronic low-grade inflammation;
• long-lasting low-grade fever;
• lack of positive effect with standard treatment.

Hyperactivation of the immune system when taking the drug is excluded. The medication does not affect normal indicators protective system, but “works” only with low or high ones.

Interaction of Polyoxidonium with other drugs

The immunomodulator combines well with other medications. It can be prescribed in combination with many NSAIDs (non-steroidal anti-inflammatory drugs), antihistamines, antifungal and antiviral drugs, antispasmodics, glucocorticosteroids, beta blockers, cytostatics, dietary supplements, vitamins.

Use of Polyoxidonium in conjunction with antimicrobial agents has a number of advantages. Thus, the antibiotic reduces the activity of the pathogen, and if we use Polyoxidonium without wasting time, then the phagocytes begin to perform their functions at double speed. " Double punch“kills the “enemy” outright, leaving him no chance. In addition, Polyoxidonium reduces immune suppression after antibiotic therapy and reduces the risk of complications.

Analogues of Polyoxidonium

Complete analogues (preparations containing identical active substance) Polyoxidonium does not have. But it has analogs that are similar in action. There are quite a lot of them - Galavit, Cycloferon, Immunorm, Taktivin, Estifan, Imunorix, Glutoxim and others. However, the mechanism of action is different. Some drugs are more effective in the fight against viral infection, the second - with bacterial, the third - with fungal. Polioskidonium not only eliminates infection of any etiology, but also has a detoxifying and antioxidant effect.

Conclusion: A good complex-action immunomodulator that has different shapes release and can be prescribed to adults and children for a long time.

Catad_pgroup Immunomodulators

Polyoxidonium lyophilisate - official instructions by application

Registration number:

P N002935/02

Trade name:

Polyoxidonium®

International nonproprietary name:

Azoximer bromide (Azoximeri bromidum)

Chemical name:

Copolymer of 1,4-ethylenepiperazine N-oxide and (N-carboxymethyl)-1,4-ethylenepiperazinium bromide

Dosage form:

lyophilisate for the preparation of solution for injection and topical use

Composition for 1 bottle:

Active ingredient: Azoximer bromide – 3 mg or 6 mg;

Excipients: mannitol – 0.9 mg, povidone K 17 – 0.6 mg (for a dosage of 3 mg); mannitol – 1.8 mg, povidone K 17 – 1.2 mg (for a dosage of 6 mg).

Description:

porous mass white with a yellowish tint.

Pharmacotherapeutic group:

immunomodulatory agent.

ATX code:

Pharmacological properties

Pharmacodynamics

Azoximer bromide has a complex effect: immunomodulatory, detoxifying, antioxidant, moderate anti-inflammatory.

The basis of the mechanism of immunomodulatory action of Azoximer bromide is a direct effect on phagocytic cells and natural killer cells, as well as stimulation of antibody formation, the synthesis of interferon-alpha and interferon-gamma.

Detoxification and antioxidant properties Azoximer bromide is largely determined by the structure and high-molecular nature of the drug. Azoximer bromide increases the body's resistance to local and generalized infections of bacterial, fungal and viral etiology. Restores immunity in secondary immunodeficiency conditions caused by various infections, injuries, complications after surgical operations, burns, autoimmune diseases, malignant neoplasms, the use of chemotherapeutic agents, cytostatics, steroid hormones.

A characteristic feature of Azoximer bromide when applied locally (intranasally, sublingually) is the ability to activate factors of the body's early defense against infection: the drug stimulates the bactericidal properties of neutrophils, macrophages, enhances their ability to absorb bacteria, increases the bactericidal properties of saliva and secretions of the mucous membranes of the upper respiratory tract.

Azoximer bromide blocks soluble toxic substances and
microparticles, has the ability to remove toxins, salts from the body heavy metals, inhibits lipid peroxidation, both by intercepting free radicals and by eliminating catalytically active Fe2+ ions. Azoximer bromide reduces the inflammatory response by normalizing the synthesis of pro- and anti-inflammatory cytokines.

Azoximer bromide is well tolerated, does not have mitogenic, polyclonal activity, antigenic properties, does not have allergenic, mutagenic, embryotoxic, teratogenic or carcinogenic effects. Azoximer bromide
has no odor or taste, has no local irritating effect when applied
on the mucous membranes of the nose and oropharynx.

Pharmacokinetics

Azoximer bromide is characterized by rapid absorption and high speed distribution in the body. The maximum concentration of the drug in the blood at intramuscular injection achieved in 40 minutes. The half-life for different ages is from 36 to 65 hours. The bioavailability of the drug is high: more than 90% when administered parenterally.

Azoximer bromide is quickly distributed throughout all organs and tissues of the body, penetrates the blood-brain and blood-ophthalmic barriers. There is no cumulative effect. In the body of Azoximer, bromide undergoes biodegradation to low molecular weight oligomers, is excreted mainly by the kidneys, with feces -
no more than 3%.

Indications for use

It is used in adults and children from 6 months for the treatment and prevention of infectious and inflammatory diseases (viral, bacterial and fungal etiology), in the acute and remission stages.

For the treatment of adults (in complex therapy):

• chronic recurrent infectious and inflammatory diseases various localizations, bacterial, viral and fungal etiology in the acute stage;
• acute viral, bacterial infections of the ENT organs, upper and lower respiratory tract, gynecological and urological diseases;
• acute and chronic allergic diseases(including hay fever, bronchial asthma, atopic dermatitis), complicated by bacterial, viral and fungal infections;
• malignant tumors during and after chemotherapy and radiation therapy to reduce immunosuppressive, nephro- and hepatotoxic effects medicines;
• generalized forms of surgical infections; to activate regenerative processes (fractures, burns, trophic ulcers);
• rheumatoid arthritis, complicated by bacterial, viral and fungal infection, against the background long-term use immunosuppressants;
• pulmonary tuberculosis.

For the treatment of children over 6 months (in complex therapy):

• acute and exacerbation of chronic inflammatory diseases of any localization (including ENT organs - sinusitis, rhinitis, adenoiditis, hypertrophy of the pharyngeal tonsil, ARVI), caused by pathogens of bacterial, viral, fungal infections;
• acute allergic and toxic-allergic conditions complicated by bacterial, viral and fungal infections;
• bronchial asthma complicated by chronic respiratory tract infections;
• atopic dermatitis, complicated purulent infection;
• intestinal dysbiosis (in combination with specific therapy).

For prevention (monotherapy) in children over 6 months and adults:

• influenza and ARVI;
• postoperative infectious complications.

Contraindications

• Increased individual sensitivity;

• Pregnancy, period breastfeeding;
• Childhood up to 6 months;
• Acute renal failure.

Carefully

Chronic renal failure (used no more than 2 times a week).

Use during pregnancy and breastfeeding

Storage conditions

In a dry place at a temperature of 2 to 8 °C. Keep out of the reach of children.

Vacation conditions

On prescription.

Manufacturer / Legal entity in whose name the registration certificate was issued

Owner registration certificate and manufacturer:

NPO Petrovax Pharm LLC

Legal address / Production address / Address for filing consumer claims:

Russian Federation, 142143, Moscow region, Podolsky district, village. Cover,
st. Sosnovaya, 1

Children more often than others suffer from infectious diseases, since their immune system is not yet perfect. If the body's defenses are weakened, then the immune system is not able to control all processes occurring in the body. As a result, the child becomes vulnerable to the action of pathogens (viruses, bacteria, fungi). Every mother wants to protect her child from illness, and therefore is looking for a safe and effective drug to treat or prevent infections.

Polyoxidonium is a drug based on chemically pure components that activates the immune system and cleanses the body of toxic substances. The medication makes the body resistant to the action of pathogenic microorganisms and normalizes the immune response. An immunomodulatory agent is prescribed for recurrent infectious diseases different organs with chronic and acute course.

Description of dosage forms

Polyoxidonium is produced in the form of tablets, suppositories, and powders for preparing liquid for injection.

All dosage forms are based on azoximer bromide; they differ only in additional components:

Pills:

• mannitol;
• povidone;
• lactose with a water molecule attached;
• potato starch;
• octodecanoic acid.

Powder (lyophilisate) from which liquid for injections is prepared:

• mannitol;
• povidone.

Rectal suppositories:

• mannitol;
• povidone;
• cacao butter.

The tablets have a flat-cylindrical shape, a white-yellowish tint and an engraving “PO”. The pills are packaged in packs of 10 and 20 pieces. According to the instructions, the tablets are prohibited for children under 2 years of age. The powder looks like a porous mixture of a whitish-yellow hue. This dosage form is used to prepare injections or nasal drops that are prescribed to children.

The lyophilisate has different dosage active component: 3 mg and 6 mg. The dosage of the suppository is also different: 3 and 6 mg. They have a torpedo-shaped shape, a light yellow tint and a light aroma of cocoa beans.

Polyoxidonium is used to improve the immunity of patients of different age categories. Moreover, it can be local (pathogenic microorganisms are located on the inner shell respiratory organs) or generalized (bacteria or viruses affect all body systems) infection. The components of the drug affect phagocytes (immune cells that absorb foreign particles) and stimulate the formation of immunoglobulins.

The drug improves immunity against infections, burns, injuries, and cancer. In addition, the medication is used to restore the body's defenses during the postoperative period and after radiation therapy. Polyoxidonium cleanses the body of toxic substances.

Purpose and special instructions

Tablets are prescribed for children over 3 years of age, injections and nasal drops for newborns from six months, and the drug in the form of rectal suppositories for patients over 6 years of age. As monotherapy, Polyoxidonium is prescribed to children with recurrent herpes. In addition, the medicine is used to prevent seasonal epidemics of infections. respiratory organs and influenza (2 months before the outbreak).

The drug increases the child’s immune strength in combination with other medications for the following diseases:

• Infections of a viral, bacterial or fungal nature (complicated forms).
• Frequent exacerbation of infections with a chronic course.
• Diseases of an allergic nature (asthma, seasonal allergic rhinoconjunctivitis, etc.).
• Inflammation of the urinary tract.
• Burns and wounds that do not heal for a long time, fractures with complications.
• Chemical therapy.
• Intoxication of the liver and kidneys with drugs.
• Frequent colds(from 6 times per year).

Polyoxidonium, like any medicine, has a list of contraindications:

• Intolerance to the components of the drug.
• Functional kidney failure.
• Pregnancy and lactation.

These are contraindications for everyone pharmaceutical forms. In addition, pills are prohibited for use in patients under 3 years of age, powder - for infants up to six months or a year, and suppositories - for children under 6 years of age.

Under the supervision of a doctor, the medicine is used for chronic functional kidney failure. This limitation applies to tablets that are taken with caution for hypolactasia, lactase deficiency.

Application and dosage

As stated in the instructions, rectal suppositories prescribed to patients over 6 years of age at a dosage of 3 mg. However, doctors often use suppositories for children younger than this age. The drug is quickly absorbed into the mucous membrane and exhibits therapeutic effect. Suppositories for children under 12 years of age with a dosage of 6 mg are inserted into the anus before going to bed after hygiene procedures and defecation. The therapeutic course lasts from 10 to 20 days. The dosage and duration of use is determined by the doctor.

The tablets are taken 30 minutes before meals. Daily dosage– 1 piece 1 to 3 times in 24 hours. Therapeutic course for colds is 1 or 2 weeks. For prevention, pills are taken for 3 weeks. The pills are intended for children under 3 years of age, but doctors often prescribe them to patients aged two years. At the same time, they must carefully monitor their condition.

The powder is used to prepare injections and nasal drops. According to the instructions for use, the solution is administered intramuscularly or intravenously. The pediatrician will provide accurate information about the dose and duration of the therapeutic course after making a diagnosis. It depends on the patient’s age and symptoms. Injections are used to treat newborns and older children.

As mentioned earlier, an injection solution and nasal drops are prepared from the lyophilisate. To do this, the ampoule (3 mg) is diluted saline solution(1 ml), purified or boiled water. Then 1-3 drops of the medicine are injected into each nostril or under the tongue about 4 times in 24 hours. The prepared solution is stored in the refrigerator for 7 days. The patient's condition improves after about 3 days of regular use.

Pros of Polyoxidonium

The medication has been used in pediatrics since 2004. Compared to other immunomodulatory drugs, Polyoxidonium has the following advantages:

• Increases effectiveness in complex therapy of infectious diseases with frequent relapses and immunodeficiency conditions.
• Accelerates the recovery of patients.
• Reduces the need to use antibacterial agents for moderate diseases.
• Reduces the incidence of respiratory diseases in children in autumn and winter.
• Accelerates the discharge of sputum in diseases of the airways of viral origin.

Despite all the advantages, you should consult a doctor before using any dosage form.

Common myths about the drug

There are a number of misconceptions about the effect of Polyoxidonium on the children's body:

• The medication supposedly enters into chemical reaction with cells, as a result, they divide faster. For this reason, a child who regularly takes the drug develops faster physically. However, this is a misconception.
• With prolonged use, Polyoxidonium promotes the development of cancer.
• The child's body perceives the medication as a foreign agent. As a result, an immune response manifests itself in the form of inflammation and general poisoning.
• The drug provokes allergies because it contains milk sugar. Some patients actually suffer from lactose intolerance, this causes digestive disorders. However, the concentration of lactose in the medication is insignificant, and therefore an allergy does not develop.

These are the main myths about Polyoxidont. Your doctor will advise you on the true effect of the medication.

Alternative remedies

If there are contraindications to Polyoxidonium, the doctor will select medications with a similar principle of action:

• Cycloferon – increases immunity, eliminates the inflammatory reaction, stops the development oncological process. Suitable for patients over 4 years old, available in the form of tablets and injections.
• Rectal suppositories, injections, nasal spray Imunofan are prescribed to prevent a decrease in immunity. Used together with antiviral and antibacterial agents. Used to treat children over 2 years of age.
• Derinat is used to strengthen the body's defenses and treat inflammatory diseases. The drug is prescribed to children from the first days of life.
• Likopid is used as part of complex treatment for reduced immunity in patients with infectious diseases.
• Kipferon suppositories are used to treat infections of the upper airways, as well as hepatitis A, B, C of viral origin. The drug is contraindicated in cases of intolerance to its components and in children under six months.

Polyoxidonium analogues include Genephron, Ribomunil, Isoprinosine and others.

Most often, immunity decreases when children begin to visit kindergarten or school. The risk group also includes premature babies or patients with low body weight. Frequent colds arise due to the fact that in patients younger age category there is no immunological memory.

Polyoxidonium is a drug that is necessary fragile body child. This medication differs from its analogues in that it is used to treat infectious diseases not only with a chronic, but also with an acute course. Before using the medicine, consult your pediatrician!

Pharmacies provide a wide selection of various immunomodulators of foreign and domestic production. One of the most popular is the drug Polyoxidonium, produced by our pharmaceutical industry. It has several dosage forms used to treat adults and children.

The drug has an immunomodulatory and detoxifying effect, increases the body's resistance to all kinds of infectious diseases. Due to high efficiency and well tolerated by patients, it is included in the list of important, vital drugs.

Today we will talk about one of the forms of the drug Polyoxidonium - nasal drops, and the instructions for use and reviews about it will help you recognize this medicine. Let's find out how to use it and what contraindications this product has.

Polyoxidonium - release form

The drug is available in three dosage forms:

Tablets for internal use;
- rectal-vaginal suppositories;
- lyophilized powder intended for the preparation of solution for injections and drops.

It is important to note that the first two forms are intended for the complex treatment of adult patients and adolescents over 12 years of age.

For children younger age Polyoxidonium is prescribed in drops under the tongue and for nasal instillation. Drops activate local immunity, as a result of which the organs of the upper respiratory tract acquire higher resistance to various infectious lesions.
Polyoxidonium drops for children - indications

For children over 6 months of age, the drug is prescribed as part of complex therapy for recurrent infectious diseases that are difficult to respond to basic treatment methods.

It is used in the treatment of acute and chronic pathologies caused by bacterial, fungal or viral infection.

The drug is prescribed for acute and chronic manifestations allergies that are complicated bacterial infection: eczema, bronchial asthma, neurodermatitis, hay fever and atopic dermatitis.

Indications for use are also intestinal dysbiosis.

Application

According to the instructions for use, lyophilized powder for preparing the solution is used as follows:

In the treatment of acute and chronic infectious diseases of severe and moderate severity, the prepared solution is administered intramuscularly or intravenously (drip).

In addition, it is used sublingually (under the tongue) or intranasally (drops in the nose).

The chosen treatment method, dosage and duration of treatment are determined by the doctor, taking into account the patient’s age and the severity of the disease.

Nasal drops - rules of use and dosage

Intranasal drops are used for the treatment and prevention of acute respiratory infections (ARVI, influenza).

Usually the drug is prescribed to children if they get sick, at least five times a year. If they escalate chronic diseases, the temperature is elevated for a long time (about 38C), and also if the prescribed treatment with other medications does not have an effect.

Daily dosage is determined taking into account the patient’s body weight: 1 drop (150 mcg) per 1 kg of weight. For example:

Weight up to 5 kg - 5 drops per day;
- 10 kg – 10 drops per day;
- 15 kg – 15 drops per day;
- 20 kg – 20 drops per day.

Instilled into the nose: 1-3 drops on each nostril, every 2-4 hours. Treatment from 5 to 10 days. Under the tongue: 1-3 drops, every 2-3 hours. Treatment from 10 to 20 days.

Preparation of drops

To prepare drops that are used under the tongue and for instillation into the nose:

Lyophilisate 3 mg is diluted with distilled water 1 ml or 20 drops.
Lyophilisate 6 mg is diluted with distilled water 2 ml or 40 drops.

The resulting solution is thoroughly mixed and stored in the refrigerator for no more than 7 days.

Contraindications and side effects

The drug has a minimum of contraindications and is well tolerated by patients. So, this remedy Not prescribed for babies under 6 months. It cannot be used if you are hypersensitive.

In some cases, the use of Polyoxidonium may provoke allergic reaction: skin rashes, hives, swelling, as well as shortness of breath and dry mouth.

Polyoxidonium nasal drops - reviews

We have been taking this preventive medicine for two years now. Our pediatrician prescribed Polyoxidonium after my daughter got sick three times in a row in the winter. Since starting to use the drops, my daughter gets sick much less often.

The drug helps us a lot. It quickly copes with the infection, and if the child is already sick, he recovers quickly. For prevention, we take it with the whole family.

Among the overwhelming advantages positive feedback, there are also these on the network:

After starting treatment with this remedy, the child’s rhinitis lasted a week! It was as if there was no treatment. Then we went back to kindergarten, and a week later I got sick again. We sat at home for a week, received treatment, and took Polyoxidonium drops. Then we went to the garden, the child then developed a fever again. The doctor prescribed an antibiotic. Unfortunately, the drug did not help us.

In conclusion of our conversation, it should be noted that Polyoxidonium is an effective drug that helps stimulate the immune system. Thanks to it, the body activates its defenses in the fight against pathogenic microorganisms. However, it does not replace or work in place of the immune system.

This drug has been on the pharmacy market for quite a long time - more than 20 years. Reviews about it are mostly positive. It is sold in pharmacies without a prescription, but should only be prescribed by a doctor. The doctor also determines the dosage of use and duration of use.

Before you start using this medicine, carefully read the instructions that come with each package of the drug. Be healthy!